If the filing person has previously filed a statement on Schedule 13G
to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e),
240.13d-1(f) or 240.13d-1(g), check the following box. [ ]
* The remainder of this cover page shall be filled out for a
reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page
shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).
1
|
Names of Reporting Persons.
RA Capital Management, LLC
|
2
|
Check the Appropriate Box if a Member of a Group (See Instructions)
|
|
(a) [ ]
|
|
(b) [ ]
|
3
|
SEC Use Only
|
4
|
Source of Funds (See Instructions):
AF
|
5
|
Check if disclosure of legal proceedings
is required pursuant to Items 2(d) or 2(e):
[ ]
|
6
|
Citizenship or Place of Organization.
Massachusetts
|
Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
|
7 Sole Voting Power
0 shares
|
8 Shared Voting Power
591,070 shares
|
9 Sole Dispositive Power
0 shares
|
10 Shared
Dispositive Power
591,070 shares
|
11
|
Aggregate Amount Beneficially Owned by Each Reporting Person
591,070 shares
|
12
|
Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) [ ]
|
13
|
Percent of Class Represented by Amount in Row (11)
6.0%
1
|
14
|
Type of Reporting Person (See Instructions)
IA, OO (Limited Liability Company)
|
|
|
|
|
1
The reporting person is the beneficial owner of 591,070 shares of the Issuer’s Common Stock which constitute
approximately 6.0% of the class outstanding. The percentage calculation assumes that there are currently 9,925,247 outstanding
shares of Common Stock of the Issuer, based on the Issuer’s Form 8-K as filed with the Securities and Exchange Commission
(“SEC”) on November 23, 2016.
1
|
Names of Reporting Persons.
Peter Kolchinsky
|
2
|
Check the Appropriate Box if a Member of a Group (See Instructions)
|
|
(a) [ ]
|
|
(b) [ ]
|
3
|
SEC Use Only
|
4
|
Source of Funds (See Instructions):
AF
|
5
|
Check if disclosure of legal proceedings
is required pursuant to Items 2(d) or 2(e):
[ ]
|
6
|
Citizenship or Place of Organization.
United
States
|
Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
|
7 Sole Voting Power
0 shares
|
8 Shared Voting Power
591,070 shares
|
9 Sole Dispositive Power
0 shares
|
10 Shared
Dispositive Power
591,070 shares
|
11
|
Aggregate Amount Beneficially Owned by
Each Reporting Person
591,070 shares
|
|
12
|
Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) [ ]
|
|
13
|
Percent of Class Represented by Amount
in Row (11)
6.0%
2
|
|
14
|
Type of Reporting Person (See Instructions)
HC, IN
|
|
|
|
|
|
2
The reporting person
is the beneficial owner of 591,070 shares of the Issuer’s Common Stock which constitute approximately 6.0% of the class
outstanding. The percentage calculation assumes that there are currently 9,925,247 outstanding shares of Common Stock of the Issuer,
based on the Issuer’s Form 8-K as filed with the Securities and Exchange Commission (“SEC”) on November 23,
2016.
SCHEDULE 13D
Item 1. Security and Issuer
This Schedule 13D relates to common
stock, par value $0.001 per share (the “Common Stock”), of Kalvista Pharmaceuticals, Inc. (the “Issuer”). The
address of the principal executive offices of the Issuer is: One Kendall Square, Bldg 200, Ste 2203: Cambridge, MA 02139.
Item 2. Identity and Background
(a) This Schedule 13D is being
filed on behalf of (i) Peter Kolchinsky and (ii) RA Capital Management, LLC (“RA Capital” and together with
Mr. Kolchinsky, the “Reporting Persons”).
RA Capital is the general partner of RA
Capital Healthcare Fund, L.P. (the “Fund”) and serves as investment adviser for a separately managed account (the “Account”).
Mr. Kolchinsky is the manager of RA Capital. As the investment adviser to the Fund and the Account, RA Capital may be deemed a
beneficial owner, for purposes of Section 13(d) of the Securities Exchange Act of 1934 (the “Act”), of any securities
of the Issuer owned by the Fund or the Account. As the manager of RA Capital, Mr. Kolchinsky may be deemed a beneficial owner,
for purposes of Section 13(d) of the Act, of any securities of the Issuer beneficially owned by RA Capital. RA Capital and Mr.
Kolchinsky disclaim beneficial ownership of the securities reported in this Schedule 13D Statement (the “Statement”)
other than for the purpose of determining their obligations under Section 13(d) of the Act, and neither the filing of the Statement
nor the filing of this Amendment shall not be deemed an admission that either RA Capital or Mr. Kolchinsky is or was the beneficial
owner of such securities for any other purpose.
(b) The business address of each of
the Reporting Persons is: 20 Park Plaza, Suite 1200, Boston, MA 02116.
(c) RA Capital is a registered investment
adviser and provides investment management services to the Fund and the Account. The principal occupation of Mr. Kolchinsky is
investment management.
(d) None of the Reporting Persons
has, during the last five years, been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).
(e) None of the Reporting Persons
has, during the last five years, been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction
and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.
(f) See Item 6 of the cover pages.
Item 3. Source and Amount of Funds
or Other Consideration
The Reporting Persons acquired the
Common Stock in exchange for 2,030,354 shares of KalVista Pharmaceuticals, Ltd. Series B Preferred shares in connection with
the closing of the share purchase transaction (the “Transaction”) whereby KalVista Pharmaceuticals, Ltd. became a
wholly-owned subsidiary of Carbylan Therapeutics, Inc., which changed its name to KalVista Pharmaceuticals, Inc.. On the
effective date of the Transaction, November 21, 2016, the closing price of the Issuer’s common stock was $9.38 per
share. The Series B Preferred shares of KalVista Pharmaceuticals, Ltd. were acquired with the investment capital of the Fund
and the Account.
Item 4. Purpose of Transaction
The Reporting Persons acquired the Common
Stock reported herein for investment purposes and not with an intent, purpose or effect of changing control of the Issuer. Although
the Reporting Persons currently have no plan or proposal to acquire any additional Common Stock or to dispose of any of the Common
Stock reported herein, the Reporting Persons may acquire additional Common Stock from time to time or dispose of Common Stock they
beneficially own, consistent with their investment purposes and in amounts to be determined by the Reporting Persons based upon
a number of factors, including, without limitation, their ongoing assessment of the Issuer's business prospects, prevailing market
conditions, the availability of other investment opportunities, and/or other considerations.
In addition, consistent with their investment
purpose, the Reporting Persons may engage in communications with persons associated with the Issuer, including shareholders of
the Issuer, officers of the Issuer and/or members of the board of directors of the Issuer, to discuss matters regarding the Issuer,
including but not limited to its operations and strategic direction. Mr. Rajeev Shah, a manager of RA Capital, currently serves
as a director of the Issuer and therefore will engage in regular discussions with the Issuer’s board of directors and management
as part of his duties as a director.
The Reporting Persons have no plans or
proposals that relate to, or could result in, any of the matters referred to in paragraphs (a) through (j), inclusive, of the instructions
to Item 4 of Schedule 13D.
The Reporting Persons may, however, change
their purpose and formulate and implement plans or proposals with respect to the Issuer at any time and from time to time. Any
such action may be made by the Reporting Persons alone or in conjunction with other shareholders, potential acquirers, financing
sources and/or other third parties and could include one or more purposes, plans or proposals that relate to or would result in
actions required to be reported herein in accordance with Item 4 of Schedule 13D.
Item 5. Interest in Securities of
the Issuer
(a) and (b) See Items 7-11 of the cover
pages and Item 2 above.
(c) The following table lists the Reporting
Persons’ transactions in Common Stock that were effected during the sixty day period prior to the filing of this Schedule
13D:
Transaction
|
Date
|
No. Shares
|
Price
|
Conversion
|
21-Nov-2016
|
591,070
|
(*)
|
(*) As described above in Item 3, the Reporting
Persons acquired beneficial ownership of the Series B-1 Preferred shares in June 2015 in a private placement. The Series B Preferred
shares converted automatically (after a 1-for-14 reverse stock split effected by the Issuer on November 21, 2016) into Common Stock.
On the effective date of the Transaction, the closing price of the Company’s common stock was $9.38 per share.
(d) Not applicable.
(e) Not applicable.
Item 6. Contracts, Arrangements,
Understandings or Relationships with Respect to Securities of the Issuer
The Reporting Persons have entered into
a standard lock-up agreement with the Issuer and the underwriters of the IPO, prohibiting any sale of the Common Stock reported
herein during the 180 days following the closing of the offering. The Reporting Persons may be released from lock-up prior to the
expiration of the lock-up period at the sole discretion of the underwriters.
Item 7. Material to Be Filed as Exhibits
Exhibit 1 Joint Filing Agreement by
and among the Reporting Persons.
SIGNATURE
After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: February 14, 2017
RA CAPITAL MANAGEMENT, LLC
By:
/s/ Peter Kolchinsky
Peter Kolchinsky
Manager
PETER KOLCHINSKY
/s/ Peter Kolchinsky
Exhibit 1
JOINT FILING AGREEMENT
This Joint Filing Agreement,
dated as of February 14, 2017, is by and among RA Capital Management, LLC and Peter Kolchinsky (the foregoing are collectively
referred to herein as the “Filers”).
Each of the Filers
may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13G and/or 13D with respect
to Common Stock of Kalvista Pharmaceuticals, Inc. beneficially owned by them from time to time.
Pursuant to and in
accordance with Rule 13(d)(1)(k) promulgated under the Securities Exchange Act of 1934, as amended, the Filers hereby agree to
file a single statement on Schedule 13G and/or 13D (and any amendments thereto) on behalf of each of such parties, and hereby further
agree to file this Joint Filing Agreement as an exhibit to such statement, as required by such rule.
This Joint Filing Agreement
may be terminated by any of the Filers upon one week’s prior written notice or such lesser period of notice as the Filers
may mutually agree.
Executed and delivered
as of the date first above written.
RA CAPITAL MANAGEMENT, LLC
By:
/s/ Peter Kolchinsky
Peter Kolchinsky
Manager
PETER KOLCHINSKY
/s/ Peter Kolchinsky