Report of Foreign Issuer (6-k)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 6-K

REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16

UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the month of October 2014

Commission File Number 001-33042

ROSETTA GENOMICS LTD.

(Translation of registrant’s name into English)

10 Plaut Street, Science Park

Rehovot 76706, Israel

(Address of Principal Executive Offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:

Form 20-F þ Form 40-F ¨

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ¨

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ¨

Rosetta Genomics Ltd.

A copy of a supplemental notice and proxy statement for the annual general meeting of shareholders of Rosetta Genomics Ltd. to be held on Wednesday, November 5, 2014 is filed as Exhibit 99.1 hereto and incorporated by reference herein.

Exhibits

Exhibit
Number		Description of Exhibit
99.1		Supplemental notice and proxy statement relating to the annual general meeting of shareholders of Rosetta Genomics Ltd. to be held on November 5, 2014.

Signatures

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	ROSETTA GENOMICS LTD.

Date: October 15, 2014	By:	/s/ Oded Biran
		Oded Biran
		General Counsel and Secretary

Exhibit 99.1

ROSETTA GENOMICS LTD.

10 Plaut St., Rabin Science Park

Rehovot, 76706

Israel

Phone number +972-73-222-0700

SUPPLEMENTAL NOTICE OF ANNUAL GENERAL MEETING OF SHAREHOLDERS

To Be Held On November 5, 2014

Notice is hereby given that an Annual General Meeting (the “Annual Meeting”) of the shareholders of Rosetta Genomics Ltd. (the “Company”), an Israeli corporation, will be held at the offices of the Company at 10 Plaut St., Rehovot, Israel on November 5, 2014 at 10:00 am (ET).

The agenda of the meeting shall be as follows:

Approval of the re-election of Mr. Brian A. Markison to serve as a Class I director of the Company for a 3 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association; and

Approval of the re-election of Dr. Yitzhak Peterburg to serve as a Class I director of the Company for a 3 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association; and

Approval of the re-appointment of Kost, Forer, Gabbay & Kasierer, a member firm of Ernst & Young Global (“KFGK”), as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2014, and until the next Annual Meeting, and to authorize the Audit committee and the Board of Directors of the Company to determine the remuneration of KFGK in accordance with the volume and nature of their services; and

Approval of the addition of 900,000 ordinary shares, nominal (par) value NIS 0.6 each (“Ordinary Shares”), to the shares authorized for issuance under the Company’s 2006 Employee Incentive Plan (Global Share Incentive Plan (2006)) (“GSIP”), so that the total number of Ordinary Shares authorized for issuance under the GSIP will equal 1,803,739; and

Approval effective as of January 1, 2014, in accordance with Section 272(c1)(1) of the Israeli Companies, Law, 5759-1999 (the “Companies Law”) of an extension, to the amendment dated June 3, 2012 of the employment agreement of Mr. Ken Berlin, the Chief Executive Officer of the Company. According to such amendment, the CEO is entitled to a base salary at the annual rate of $500,000 USD, payable bi-weekly or otherwise in accordance with the payroll policy of the Company, set to expire at the Company’s 2015 Annual Shareholder Meeting; and

Approval, in accordance with Section 272(c1)(1) of the Companies, Law, for Mr. Ken Berlin, the Chief Executive Officer of the Company, of a grant of options to purchase up to 100,000 Ordinary Shares of the Company at an exercise price per share equal to the closing price on the date of grant, which shall be November 30, 2014, vesting in equal installments quarterly over a period of four (4) years beginning on November 30, 2014, and such options shall expire seven (7) years after the date of grant, unless they expire earlier in accordance with the terms of the GSIP and 20,000 Restricted Stock Units (“RSUs”) vesting in equal installments annually over a period of four (4) years beginning on November 30, 2014. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP; and.

Replacement of Section 38 of the Company’s Articles of Association with the following: “The Board of Directors of the Company shall consist of not less than two (2) nor more than seven (7) Directors”; and

Discussion of the Consolidated Financial Statements of the Company for the fiscal year ended December 31, 2013.

According to the Companies Law, one or more shareholders who hold at least 1% of the voting rights in the General Meeting may request that the Board of Directors include a subject matter on the agenda of a General Meeting. Pursuant to such a request made by Messrs. Israel Makov, who allegedly owns 1.69 % and Nachum (Homi) Shamir, who allegedly owns 1.67% of the Company's outstanding share capital, the following items have been added to the agenda:

Providing there are available vacancies on the Company's Board of Directors, according to Article 38 of the Company's Articles of Association, election of Mr. Nachum (Homi) Shamir to serve as a Class II director of the Company for a 1 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2015 in accordance with the Company’s Articles of Association; and

10.

Providing there are available vacancies on the Company's Board of Directors, according to Article 38 of the Company's Articles of Association, election of Mr. Doron Birger to serve as a Class I director of the Company for a 3 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association; and

11.

Providing there are available vacancies on the Company's Board of Directors, according to Article 38 of the Company's Articles of Association, election of Mr. Ori Hershkovitz to serve as a Class III director of the Company for a 2 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2016 in accordance with the Company’s Articles of Association.

The approval of each of Item 1, Item 2 and Items ‎9 through 11 requires the affirmative vote of a majority of the shares represented and voting on the nomination of directors at the Annual Meeting in person or by proxy. The approval of each of Item 3, Item 4 and Item 7 requires the affirmative vote of a majority of the shares represented and voting at the Annual Meeting in person or by proxy.

The approval of Item ‎5 and Item 6 requires the affirmative vote of the holders of a majority of the voting power represented and voting on the matter in person or by proxy, provided that (i) such a majority includes at least a majority of the ordinary shares voted by shareholders who are not controlling shareholders of the Company nor are they shareholders who have a personal interest in the approval of the proposal set forth in Item ‎5 and Item 6; or (ii) the total number of shares of non-controlling shareholders and non-interested shareholders voted against the proposal in Item 5 must not represent more than two percent (2%) of the total voting rights in the Company. Abstentions shall not be taken into account in counting the above-referenced shareholder votes.

Under the Companies Law, in general, a person will be deemed to be a controlling shareholder if the person has the power to direct the activities of the company, including a shareholder holding 25% or more of the voting rights if no other shareholder owns more than 50% of the voting rights in the company, but excluding a shareholder whose power derives solely from his or her position on the board of directors or any other position with the company. If two or more shareholders are interested parties in the same transaction, their shareholdings are combined for the purposes of calculating percentages. A shareholder holding 50% or more of the voting rights of the Company is presumed to be a controlling shareholder.

A shareholder will be deemed to have a personal interest if he or she has personal interest in an act or transaction of the company, including a personal interest of his or her relative or of a corporate body in which that person or a relative of that person is a holder of 5% or more of that corporate body’s outstanding shares or voting rights, is a director or general manager, or in which he or she has the right to appoint at least one director or the general manager. For that matter according to the Companies Law - “Personal interest” does not apply to a personal interest stemming merely from the fact that the office holder is also a shareholder in the company. In addition, the term “personal interest” also includes the personal interest of a person voting under a proxy given by another person, even if such appointing person has no personal interest in the proposed act or transaction. In addition, the vote of a person voting under a proxy given by a person having a personal interest in the proposed act or transaction, even if the person voting under the proxy has no personal interest, shall be deemed as a vote made by a person having a personal interest in the proposed act or transaction. The Companies Law defines a “relative” as a person’s spouse, sibling, parent, grandparent or descendent, as well as the descendant, sibling or parent of a person’s spouse, or the spouse of any of the foregoing.

With regards to the approval of Item 5 and Item 6, you will be asked to indicate whether or not you are a controlling shareholder of the Company and whether or not you have a personal interest in the proposal set forth in Item ‎5 and Item 6. If any shareholder casting a vote in connection hereto does not notify us whether or not it is a controlling shareholder of the Company or whether or not it has a personal interest in the approval of the proposal set forth in Item ‎5 and Item 6, such shareholder's vote with respect to such Item will be disqualified.

Only Shareholders of record at the close of trading on September 30, 2014 will be entitled to receive notice of, and to vote at, the Annual Meeting. All shareholders are cordially invited to attend the Annual Meeting in person. Discussion at the Annual Meeting will be commenced if a quorum is present. Two or more shareholders present, personally or by proxy, who hold or represent together more than 25% of the voting rights of our issued share capital will constitute a quorum for the Annual Meeting. If within half an hour from the time scheduled for the Annual Meeting, a quorum is not present, the Annual Meeting shall be adjourned to exactly one week after the original meeting date at the same time and place. At any such adjourned meeting, any two shareholders who are present in person or by proxy shall constitute a quorum.

Shareholders who do not expect to attend the Annual Meeting in person may vote with respect to items 1 through 7 and 9 through 11 by means of a Proxy Card. Joint holders of shares should take note that, pursuant to Article 32 of the Company’s Articles of Association, the vote of the senior holder who tenders a vote, in person or by Proxy Card, will be accepted to the exclusion of the vote(s) of the other joint holder(s), and for this purpose seniority will be determined by the order of registration of the joint holders in the Company’s shareholder register. In order to be counted, a duly executed Proxy Card must be delivered to the Company’s registered office at 10 Plaut St., Rabin Science Park, Rehovot, 76706, Israel or to the office of the Company’s tabulation agent, MacKenzie Partners, Inc., 105 Madison Avenue, New York, NY 10016, not less than two (2) hours before the time fixed for the Annual Meeting unless such requirement is waived by the chairman of the Annual Meeting. Shareholders who attend the Annual Meeting and provide the required information may revoke their Proxy Cards and vote their shares in person.

UNLESS A DULY EXECUTED SUPPLEMENTAL PROXY CARD DETAILING A SHAREHOLDER’S VOTE ON ITEMS 9 THROUGH 11 IS RECEIVED IN ACCORDANCE WITH THE ABOVE, A PROXY CARD IN THE FORM THAT WAS PUBLISHED BY THE COMPANY ON OCTOBER 1, 2014, PRIOR TO THE ADDITION OF ITEMS TO THE AGENDA ACCORDING TO THE SHAREHOLDERS’ REQUEST, STATED ABOVE, WILL REMAIN VALID AND SAID SHAREHOLDER’S VOTES WILL BE CONSIDERED AS ABSTAINING VOTES ON ITEMS 9 THROUGH 11 TO THE SUPPLEMENTAL PROXY CARD.

The complete form of the proposed resolutions and relevant documents may be inspected at the offices of the Company at its above mentioned address during normal business hours, upon prior coordination with Adv. Yael Rosen, Legal Counsel, at +972-73-222-0700 and on the Company’s website at www.rosettagenomics.com.

	By order of the Board of Directors,
	/s/ Brian A. Markison
	Brian A. Markison
	Chairman of the Board
	October 15, 2014

SUPPLEMENTAL PROXY STATEMENT

ROSETTA GENOMICS LTD.

10 Plaut St., Rabin Science Park

Rehovot, 76706

Israel

Phone number +972-73-222-0700

ANNUAL GENERAL MEETING OF SHAREHOLDERS

To Be Held On November 5 ,2014

The enclosed supplemental proxy is being solicited by the Board of Directors of Rosetta Genomics Ltd. (the “Board” and the “Company”, respectively) and Mr. Israel Makov and Mr. Nachum (Homi) Shamir (the “Dissidents”) for use at our Annual General Meeting of Shareholders (the “Annual Meeting”) to be held at the offices of the Company at 10 Plaut St., Rehovot, Israel on November 5, 2014 at 10:00 am (ET), or at any postponement or adjournment thereof. The record date for determining shareholders entitled to notice of, and to vote at, the Annual Meeting has been established as of the close of trading on September 30, 2014.

As of September 30, 2014, we had outstanding 11,716,420 of our ordinary shares, nominal (par) value NIS 0.6 each (“Ordinary Shares”), each of which is entitled to one vote on each matter to be voted at the Annual Meeting¹. The votes of all shareholders voting on a matter are counted, including abstention votes.

These proxy materials have also been filed with the U.S. Securities and Exchange Commission (the “SEC”) as an exhibit to a Report on a Form 6-K and are available on the Company’s website www.rosettagenomics.com. In order to be counted, a duly executed proxy in the form attached to this proxy statement, or the form previously published by the Company, must be delivered to the Company’s registered office at 10 Plaut St., Rabin Science Park, Rehovot, 76706, Israel, to the office of the Company’s tabulation agent, MacKenzie Partners, Inc., 105 Madison Avenue, New York, NY 10016, not less than two (2) hours before the time fixed for the Annual Meeting unless such requirement is waived by the chairman of the Annual Meeting.

Upon the receipt of a properly executed proxy in the form previously published or in the form enclosed, the persons named as proxies therein will vote the Ordinary Shares covered thereby in accordance with the instructions of the shareholder executing the proxy. With respect to each proposal set forth in the accompanying Notice of Annual Meeting of Shareholders (the “Notice of Meeting”), a shareholder may vote in favor of or against the proposal or may abstain from voting on the proposal. Shareholders should specify their choice on the accompanying, or previously published proxies. A Proxy Card in the form that was published by the Company on October 1, 2014, which does not include Items 9 through 11, will be considered as a Proxy Card in which the "abstain option" was marked regarding the vote on Items 9 through 11 to the supplemental Proxy Card on those items and said shareholder’s votes will be considered as abstaining votes on items 9 through 11 to the supplemental Proxy Card.

Any shareholder returning a duly executed proxy may revoke such proxy at any time prior to its exercise by: (i) giving written notice to us of such revocation; (ii) voting in person at the Annual Meeting or requesting the return of the proxy at the Annual Meeting; or (iii) executing and delivering to us a later-dated proxy.

Discussion at the Annual Meeting will commence if a quorum is present. Two or more shareholders present, personally or by proxy, who hold or represent together more than 25% of the voting rights of our issued share capital will constitute a quorum for the Annual Meeting. If within half an hour from the time scheduled for the Annual Meeting a quorum is not present, the Annual Meeting shall be adjourned to November 12, 2014 at the same time and place. At any such adjourned meeting, any two shareholders who are present in person or by proxy shall constitute a quorum. Shares subject to broker non-votes and abstentions are counted for purposes of determining whether a quorum is present but will have no effect on whether the requisite vote is obtained for all matters placed before shareholders for their vote, as with regard to any applicable matter broker non-votes and abstentions are not counted as being present or as having been voted.

This does not include 3,257 Ordinary Shares held as treasury shares under Israeli law, all of which were repurchased by the Company. For so long as such treasury shares are owned by the Company, they have no rights and, accordingly, are neither eligible to participate in or receive any future dividends which may be paid to shareholders of the Company nor are they entitled to participate in, be voted at or be counted as part of the quorum for, any meeting of shareholders of the Company.

Item ‎5 and Item 6 to be presented at the Annual Meeting each requires the vote of the holders of a majority of the voting power represented and voting on the matter in person or by proxy, provided that (i) such a majority includes at least a majority of the ordinary shares voted by shareholders who are not controlling shareholders of the Company nor are they shareholders who have a personal interest in the approval of the proposal set forth in Item ‎5 and Item 6; or (ii) the total number of shares of non-controlling shareholders and non-interested shareholders voted against the proposal in Item ‎5 must not represent more than two percent (2%) of the total voting rights in the Company. Abstentions shall not be taken into account in counting the above-referenced shareholder votes.

With regards to the approval of Items 5 and 6, you will be asked to indicate whether or not you are a controlling shareholder of the Company and whether or not you have a personal interest in the proposal set forth in Items ‎5 and 6. If any shareholder casting a vote in connection hereto does not notify us whether or not it is a controlling shareholder of the Company or whether or not it has a personal interest in the approval of the proposal set forth in Items 5 and 6, such shareholder's vote with respect to such Item will be disqualified.

The Company is not currently aware of any controlling shareholders as such term is defined for purposes of the Israel Companies Law.

MATTERS RELATING TO THE ANNUAL GENERAL MEETING

At the Annual Meeting, the shareholders will be asked to vote on the following proposals:

PROPOSAL ONE — RE-ELECTION OF MR. BRIAN MARKISON

Background

Our Articles of Association (the “Articles”) provide that the minimum number of members of the Board is two and the maximum number is eleven². Our Board is presently comprised of seven members, two of whom are “external directors” appointed under the Companies Law. Our Board (other than the external directors) is divided into three different classes, Class I Directors, Class II Directors and Class III Directors, with one class being elected each year at the Company’s annual general meeting for a term of approximately three years.

Our directors (except for the external directors) are divided among the classes as follows:

Class I directors are: Mr. Brian A. Markison and Dr. Yitzhak Peterburg. Their term expires at this annual general meeting of shareholders³.

² Please see Item 7 on this Proxy Statement.

³ Please see Item 10 on this Proxy Statement.

Class II directors are: Dr. David Sidransky and Dr. Joshua Rosensweig. Their term expires at the annual general meeting of shareholders to be held in 2015⁴.

Class III director is: Roy N. Davis. His term expires at the annual general meeting of shareholders to be held in 2016.⁵

In addition, our two external directors, Mr. Gerald Dogon and Ms. Tali Yaron-Eldar, were initially elected by our shareholders on May 30, 2007, were then re-elected on July 14, 2010 and August 5, 2013 for three-year terms, the last of which expires on August 4, 2016.

Given the end of the term of Mr. Brian A. Markison, we are proposing that the shareholders re-elect Mr. Brian A. Markison as a director for an additional term of three years. If re-elected at this Annual Meeting, Mr. Brian A. Markison will serve until the annual general meeting of the Company’s shareholders to be held in 2017 or until his office is vacated in accordance with the Articles and the Companies Law.

The Companies Law requires that a person will not be elected and will not serve as a director in a public company if he or she does not have the required qualifications and the ability to dedicate an appropriate amount of time to the performance of his or her duties as director of the company, taking into consideration, among other factors, the special needs and size of the company. A general shareholders’ meeting of a public company, at which the election of a director is to be considered, will not be convened unless the nominee has declared to the company, inter alia, that he or she complies with the above-mentioned requirements and details of his or her applicable qualifications are provided.

Mr. Markison has declared to the Company that he complies with the required qualifications under the Companies Law for appointment as a director of the Company, detailed his applicable qualifications to the Company, and demonstrated to the Company that he is capable of dedicating the appropriate amount of time for the performance of his duties as a director. Copies of the declaration of Mr. Markison are available for inspection at the Company’s offices in Rehovot, Israel.

The following information is provided with respect to Mr. Markison and is based upon the records of the Company and information provided to it by Mr. Markison:

Brian Markison (born in the United States of America on October 1, 1959, from Princeton, N.J., USA) has served as a member of our board of directors since March 2011. Mr. Markison’s appointment was approved by the general meeting on July 6, 2011. Mr. Markison was appointed as chairman of the board on April 12, 2011. Mr. Markison is a member of our Nominating and Corporate Governance Committee. Mr. Markison has been a Healthcare Industry Executive at Avista Capital Partners since September 2012, prior to which he served as President, Chief Executive Officer and a member of the Board of Directors of Fougera Pharmaceuticals Inc., from July 2011, until it was sold to the generics division of Novartis in July 2012. Previously, he had been with King Pharmaceuticals since 2004 and led the company through its acquisition by Pfizer for $3.6 billion in 2010. Previously Mr. Markison was with Bristol-Myers Squibb from 1982 to 2004, where he served in various commercial and executive positions rising from an oncology sales representative to become President, BMS Oncology/Virology and Oncology Therapeutics Network. Mr. Markison serves on the board of directors of Immunomedics, Inc., PharmAthene Inc., Lantheus Medical Imaging and Alere Inc, and is the excutive Chairman of Trigen/Vertical. He also serves on the board of directors for the Komen Foundation, the College of New Jersey. Mr. Markison received a B.S. from Iona College in New Rochelle, New York.

The address for Mr. Markison is c/o Rosetta Genomics Ltd., 10 Plaut Street, Science Park, Rehovot 76706 Israel.

Assuming Mr. Brian Markison is re-elected and appointed by the board as chairman of the board, he will be entitled to receive: (1) remuneration in an amount of US $25,000 plus VAT per year, and additional annual remuneration of US $10,000 plus VAT per committee Mr. Markison is a member of (2) payment of a participation fee of the higher of: (a) US $250 plus VAT; or (b) the minimal participation fee according to the Israeli Companies Law 1999, and the regulations promulgated pursuant thereto (as of the date hereof – US $346.80), for every Board or Board committee meeting including, inter alia, meeting by means of communication (teleconferences) and unanimous written resolutions, (3) options to purchase 48,000 Ordinary Shares, at an exercise price per share equal to the closing price on the date of the Annual Meeting, vesting in equal installments annually over a period of three years beginning on the date of the Annual Meeting and such options shall expire seven years after their date of grant, unless they expire earlier in accordance with the terms of the Company's 2006 Employee Incentive Plan (Global Share Incentive Plan (2006)) (the “GSIP”), and (4) 10,000 Restricted Stock Units (“RSUs”) upon the commencement of each twelve-month period in office as a director beginning on the date of the Annual Meeting. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP, except that the exercise period of the options and RSUs upon termination shall be six months.

⁴ Please see Item 9 on this Proxy Statement.

⁵ Please see Item 11 on this Proxy Statement.

THE BOARD OF DIRECTORS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

“RESOLVED, to re-elect Mr. Brian A. Markison, as a Class I director, to serve for a term of three years, until the 2017 annual general meeting of shareholders.”

An affirmative vote of a majority of the shares represented and voting on the nomination of directors at the Annual Meeting in person or by proxy is required for the approval of such resolution.

Board of Directors’ Recommendation:

THE BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE “FOR” THE ABOVE PROPOSED RESOLUTION.

PROPOSAL TWO — RE-ELECTION OF DR. YITZHAK PETERBURG

Background

Given the end of the term of Dr. Yitzhak Peterburg, we are proposing that the shareholders re-elect Dr. Yitzhak Peterburg as a Class I Director of the Company for an additional term of three years. If re-elected at this Annual Meeting, Dr. Yitzhak Peterburg will serve until the annual general meeting of the Company’s shareholders to be held in 2017 or until such director’s office is vacated in accordance with the Company’s Articles and the Companies Law.

Dr. Peterburg has declared to the Company that he complies with the required qualifications under the Companies Law for appointment as a director of the Company, detailed his or her applicable qualifications to the Company, and demonstrated to the Company that he is capable of dedicating the appropriate amount of time for the performance of his duties as a director. Copies of the declaration of the proposed nominee are available for inspection at the Company’s offices in Rehovot, Israel.

The following information is provided with respect to Dr. Peterburg and is based upon the records of the Company and information provided to it by Dr. Peterburg:

Dr. Yitzhak Peterburg (born on February 18, 1951, ID No. 50510676, from Tal Shachar, Israel) has served as a member of our board of directors since December 2012. Dr. Peterburg is a member of our Nominating and Corporate Governance Committee and of our Research and Development Committee. He currently serves on the Board of Directors of TEVA Pharmaceuticals, prior to which he served as TEVA’s Senior Vice President, Head of Global Branded Products from October 2010 until October 2011, prior to which he served on the board of TEVA from 2009 until July 2010. Prior to his positions with TEVA, between the years of 2003 to 2005, Dr. Peterburg was President and CEO of Cellcom, one of Israel’s leading cellular companies. Between the years of 1990 to 2002, Dr. Peterburg was with Clalit Health Services, a non-governmental, not-for-profit organization that provides comprehensive health services to more than 55% of the Israeli population. From 1997 to 2002 he served as General Manager (CEO) for Clalit Health Services and from 1990 to 1997 he held a series of senior executive positions including Head, Health Policy Division and Chief Information Officer, Medical Division. Among his many positions at Clalit, from 1995-1997, Dr. Peterburg served as CEO of Soroka University Medical Center, Beer-Sheba, Israel, one of the biggest university hospitals in Israel. Dr. Peterburg received an M.D. from the Hebrew University of Jerusalem, and holds a Ph.D. in health services administration from the Columbia University School of Public Health in New York and a master’s degree in information systems from the London School of Economics.

The address for Dr. Peterburg is c/o Rosetta Genomics Ltd., 10 Plaut Street, Science Park, Rehovot 76706 Israel.

Dr. Peterburg shall receive remuneration that is equal to the remuneration paid to the other directors of the Company (except for the Chairman of the Board who receives higher remuneration). In accordance with prior resolutions of the Company's Audit Committee, Board and shareholders meetings that were held on October 12, 2012, and On August 5, 2013 each of the Company's directors (except for the Chairman of the Board) is entitled to receive: (1) remuneration in an amount of US $20,000 plus VAT per year, paid in equal quarterly installments, and a director who serves as a member of a Committee formed by the Board shall be entitled to additional annual remuneration of US $7,500 plus VAT per committee, and (2) payment of a participation fee of the higher of: (a) US $250 plus VAT; or (b) the minimal participation fee according to the Companies Law, and the regulations promulgated pursuant thereto (as of the date hereof – US $346.8), for every Board or Board committee meeting including, inter alia, meeting by means of communication (teleconferences) and unanimous written resolutions.

In addition, each of the Company's directors (except for the Chairman of the Board who receives higher remuneration) is entitled to receive: (1) options to purchase 24,000 Ordinary Shares, at an exercise price per share equal to the closing price on the date of the shareholders’ meeting approving the nomination of the Director, vesting in equal installments annually over a period of three years beginning on such date and such options shall expire seven years after their date of grant, unless they expire earlier in accordance with the terms of the GSIP, and (2) 5,000 RSUs upon the commencement of each twelve months period in office as a director beginning on the date of the shareholders meeting approving the nomination of the Director. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP, except that the exercise period of the options and RSUs upon termination shall be six months.

Assuming Dr. Yitzhak Peterburg is re-elected, he will be entitled to receive: (1) remuneration in an amount of US $20,000 plus VAT per year, and additional annual remuneration of US $7,500 plus VAT per committee Dr. Peterburg is a member of (2) payment of a participation fee of the higher of: (a) US $250 plus VAT; or (b) the minimal participation fee according to the Israeli Companies Law 1999, and the regulations promulgated pursuant thereto (as of the date hereof – US $346.8), for every Board or Board committee meeting including, inter alia, meeting by means of communication (teleconferences) and unanimous written resolutions, (3) options to purchase 24,000 Ordinary Shares, at an exercise price per share equal to the closing price on the date of the Annual Meeting, vesting in equal installments annually over a period of three years beginning on the date of the Annual Meeting and such options shall expire seven years after their date of grant, unless they expire earlier in accordance with the terms of the GSIP, and (4) 5,000 RSUs upon the commencement of each twelve-month period in office as a director beginning on the date of the Annual Meeting. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP, except that the exercise period of the options and RSUs upon termination shall be six months.

THE BOARD OF DIRECTORS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

“RESOLVED, to re-elect Dr. Yitzhak Peterburg as a Class I director, to serve for a term of three years, until the 2017 annual general meeting of shareholders.”

An affirmative vote of a majority of the shares represented and voting on the nomination of directors at the Annual Meeting in person or by proxy is required for the approval of such resolution.

Board of Directors’ Recommendation:

THE BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE “FOR” THE ABOVE PROPOSED RESOLUTION.

PROPOSAL THREE — APPROVAL OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING
FIRM AND AUTHORIZATION TO DETERMINE COMPENSATION

Background

At the Annual Meeting, Kost, Forer, Gabbay & Kasierer, independent registered public accountants in Israel and a member firm of Ernst & Young Global (“KFGK”), will be nominated for re-appointment as independent registered public accounting firm of the Company and its subsidiaries for the fiscal year ending December 31, 2014, and until the next annual general meeting. Under the provisions of the Sarbanes-Oxley Act of 2002, the Company’s Audit Committee is responsible for the appointment, compensation, retention and oversight of the work of the Company’s independent auditors. However, under Israeli law, the appointment of independent auditors and their compensation require the approval of the shareholders of the Company. Pursuant to Israeli law, the shareholders may delegate the authority to determine the compensation of the independent auditors to the board of directors, and the Company’s shareholders have done so in the past. In addition, pursuant to Israeli law, the Audit Committee is required to examine the independent auditor’s fees and to provide its recommendations with respect thereto to the appropriate corporate organ. Accordingly, the appointment of the independent auditors will be required to be approved and recommended to the shareholders by the Audit Committee and approved by the shareholders. The compensation of the independent auditors will be required to be approved by the Audit Committee and recommended to the shareholders or, if so authorized by the shareholders, to the Board and approved by either the shareholders or the Board, as the case may be. The Audit Committee has reviewed, and is satisfied with, the performance of KFGK, and has approved their re-appointment as the Company’s independent registered public accounting firm. Approval of that appointment, as well as authorization of the Board to determine the compensation of the independent auditors, provided such remuneration is also approved by the Audit Committee, is now being sought from the Company’s shareholders.

The Audit Committee is responsible for the oversight of its independent auditors’ scope of work. The Audit Committee’s policy is to pre-approve all audit and non-audit services provided by KFGK and other members of Ernst & Young Global. These services may include audit services, audit-related services, tax services and other services, as further described below. The Audit Committee sets forth the basis for its pre-approval in detail, listing the particular services or categories of services which are pre-approved, and setting forth a specific budget for such services. Additional services may be pre-approved by the Audit Committee on an individual basis. Once services have been pre-approved, KFGK and management then report to the Audit Committee on a periodic basis regarding the extent of services actually provided in accordance with the applicable pre-approval, and regarding the fees for the services performed.

The Company paid the following fees for professional services rendered by KFGK and other members of Ernst & Young Global, for the years ended December 31, 2012 and 2013:

	Year Ended December 31,
	2012		2013
Audit fees⁽¹⁾	$	107,000	$	103,000
Audit related fees⁽²⁾	$	75,000	$	24,879
Tax fees⁽³⁾	$	13,600	$	73,538
Total	$	195,600	$	201,417

(1)	Includes professional services rendered with respect to the audits of the Company’s annual consolidated financial statements, management’s assessment of internal control over financial reporting, review of consolidated quarterly financial statements, statutory audits of the Company and its subsidiaries, consents and assistance with review of documents filed with the SEC.

(2)	Includes consultations concerning financial accounting and reporting standards and internal control reviews and consultations and due diligence respecting accounting matters in connection with acquisitions and dispositions.

(3)	Includes fees for services related to tax compliance, including preparation of tax returns, claims for refund and assistance with audits and appeals; and tax planning and advice, including advice related to acquisitions and dispositions, services for employee benefit plans, issues with respect to transfer pricing and advice for expatriates.

(4)	Includes fees for business related consultation.

KFGK has no relationship with the Company or any affiliate of the Company except as auditors and, to a limited extent, as tax consultants. The Audit Committee believes that this limited non-audit function does not affect the independence of KFGK.

THE BOARD OF DIRECTORS WILL PRESENT THE FOLLOWING RESOLUTION AT THE ANNUAL MEETING:

“RESOLVED, that Kost, Forer, Gabbay & Kasierer, independent registered public accountants in Israel and a member firm of Ernst & Young Global, be, and they hereby are, re-appointed as independent registered public accounting firm of the Company for the fiscal year ending December 31, 2014 and until the Company’s next annual general meeting, and that the Board of Directors of the Company, be, and it hereby is, authorized to determine the remuneration of said auditors in accordance with the volume and nature of their services, provided such remuneration is also approved by the Audit Committee.”

An affirmative vote of a majority of the shares represented and voting at the Annual Meeting in person or by proxy is required for the approval of such resolution.

Board of Directors’ Recommendation:

THE BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE “FOR” THE PROPOSED RESOLUTION.

PROPOSAL FOUR — INCREASE OF THE NUMBER OF ORDINARY SHARES AVAILABLE FOR ISSUANCE UNDER THE Company’s Global SHARE Incentive Plan

Background

At the meeting of shareholders that took place on July 12, 2006, the Company's shareholders approved the GSIP, which is governed by, and interpreted in accordance with, the laws of the State of Israel.

Under the GSIP, the Company may issue either options, restricted shares or RSUs, to its employees, consultants and board members. Under the GSIP, the Company may also issue options or restricted shares to the employees, consultants and board members of its subsidiaries, including subsidiaries located in the United States. The aggregate amount of Ordinary Shares that was authorized to be issued under the GSIP upon its adoption was 12,879⁶ Ordinary Shares.

At the annual meeting of the Company’s shareholders that took place on December 22, 2009, the shareholders resolved to increase the number of Ordinary Shares available for issuance under the GSIP by 25,000 Ordinary Shares. Out of such 25,000 Ordinary Shares, approximately 16,666 Ordinary Shares were dedicated as available for grant to employees who are United States taxpayers.

At an extraordinary meeting of the Company’s shareholders that took place on July 14, 2010, the shareholders resolved that in order to allow the Company flexibility in compensating Israeli and United States employees, all 25,000 Ordinary Shares, approved by the shareholders for grant under the GSIP on December 22, 2009, be eligible for grant to all employees of the Company, irrespective of whether they are United States or Israeli taxpayers.

At the annual meeting of the Company’s shareholders that took place on October 12, 2012, our shareholders approved the addition of 853,770 Ordinary Shares of the Company to the amount of Ordinary Shares authorized for issuance under the GSIP. As of September 30, 2014, there were no Ordinary Shares available for grant under the GSIP.

THE BOARD OF DIRECTORS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

“RESOLVED, to approve, the addition of 900,000 Ordinary Shares to the amount of Ordinary Shares authorized for issuance under the GSIP so that the total number of Ordinary Shares authorized for issuance under the Company’s 2006 Employee Incentive Plan (Global Share Incentive Plan (2006)) will equal 1,803,739 and that all of these shares shall be eligible for grant to all employees of the Company, irrespective of whether they are United States or Israeli taxpayers.”

An affirmative vote of a majority of the shares represented and voting at the Annual Meeting in person or by proxy is required for the approval of such resolution.

Board of Directors’ Recommendation:

THE BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE “FOR” THE PROPOSED RESOLUTION.

PROPOSAL FIVE — TO APPROVE AN EXTENSION OF AN AMENDMENT TO THE EMPLOYMENT AGREEMENT OF MR. KEN BERLIN

Background

Kenneth A. Berlin joined us in November 2009 as our President and Chief Executive Officer. He was later appointed by our shareholders in December 2009 as a member of our board of directors, and resigned as a director in March 2011. Prior to joining us, Mr. Berlin, served as Worldwide General Manager at cellular and molecular cancer diagnostics developer Veridex, LLC, a Johnson & Johnson company. Under his leadership the organization grew to over 100 employees, and he spearheaded the launch of three cancer diagnostic products, the acquisition of its cellular diagnostics partner, and delivered significant growth in sales as Veridex transitioned from a research and development entity to a commercial provider of oncology diagnostic products and services. During Mr. Berlin’s tenure, Veridex received numerous awards including recognition from the Cleveland Clinic and Prix Galien for the use of its innovative CellSearch® technology in the fight against cancer. Mr. Berlin joined Johnson & Johnson in 1994 and served as corporate counsel for six years. He then held positions of increasing responsibility within Johnson & Johnson and a number of its subsidiary companies. From 2001 until 2004, he served as Vice President, licensing and new business development in the pharmaceuticals group, and from 2004 until 2007 was Worldwide Vice President, franchise development, Ortho-Clinical Diagnostics. Mr. Berlin holds an A.B. degree from Princeton University and a J.D. from the University of California, Los Angeles School of Law.

Mr. Berlin's original terms of Employment included a base salary of $375,000 USD, payable bi-weekly, a target bonus of up to 100% of Mr. Berlin's base salary, a starting bonus of $200,000 USD in cash upon his commencement date and three additional bonuses of $125,000 USD each conditioned upon the achievement of certain milestones. These terms of employment were amended with the approval of the Audit Committee and the Board on June 3, 2012 for the period between June 3, 2012 and December 31, 2013 to reflect a base salary of $500,000 USD, however, during that time, the discretionary bonus remained up to 100% of the original base salary, a total of $375,000 USD per year.

⁶

All amounts of Ordinary Shares in the subsection for Proposal Four entitled “Background” are adjusted to give effect to (i) a 1-for-3.9822 reverse split that took place on June 15, 2006; (ii) a 1-for-4 reverse split that took place on July 6, 2011 and (iii) a 1-for-15 reverse split that took place on May 14, 2012.

According to the Companies Law, as amended in Amendment No. 20, the terms of employment of a chief executive officer should be approved (in the following order) by (i) the compensation committee, (ii) the board of directors and (iii) by the general meeting of shareholders of the Company as set forth below.

The Company’s compensation committee and Board resolved that, subject to the approval of the Company’s shareholders at the Annual Meeting, to approve in accordance with Section 272(c1)(1) of the Companies Law., an extension to the amendment dated June 3, 2012 of the employment agreement of Mr. Ken Berlin, the Chief Executive Officer of the Company. According to such amendment, the CEO is entitled to a base salary at the annual rate of $500,000 USD, payable bi-weekly or otherwise in accordance with the payroll policy of the Company, set to expire at the Company’s 2015 Annual Shareholder Meeting;

THE BOARD OF DIRECTORS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

“RESOLVED, To approve in accordance with Section 272(c1)(1) of the Israeli Companies, Law, 5759-1999 (the "Companies Law") an extension to the amendment dated June 3, 2012 of the employment agreement of Mr. Ken Berlin, the Chief Executive Officer of the Company. According to such amendment, the CEO is entitled to a base salary at the annual rate of $500,000 USD, payable bi-weekly or otherwise in accordance with the payroll policy of the Company, set to expire at the Company’s 2015 Annual Shareholder Meeting.

An affirmative vote of the holders of a majority of the voting power represented and voting on the matter in person or by proxy, shall be required provided that (i) such a majority includes at least a majority of the ordinary shares voted by shareholders who are not controlling shareholders of the Company nor are they shareholders who have a personal interest in the approval of the proposal set forth in Item 5; or (ii) the total number of shares of non-controlling shareholders and non-interested shareholders voted against the proposal in Item 5 must not represent more than two percent (2%) of the total voting rights in the Company. Votes abstaining shall not be taken into account in counting the above-referenced shareholder votes.

A shareholder must inform the Company before the vote (or if voting by proxy, indicate on the proxy card) whether or not such shareholder is a controlling shareholder or has a Personal Interest, and failure to do so disqualifies the shareholder from participating in the vote.

Board of Directors’ Recommendation:

THE BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE “FOR” THE PROPOSED RESOLUTION.

PROPOSAL SIX — APPROVAL OF OPTIONS GRANT AND RESTRICTED STOCK UNITS GRANT FOR MR. KEN BERLIN, THE Chief Executive Officer OF THE Company

Background

The Company’s compensation committee and Board resolved that, subject to the approval of the Company’s shareholders at the Annual Meeting, Mr. Ken Berlin shall be entitled to receive a grant of options to purchase up to 100,000 Ordinary Shares of the Company at an exercise price per share equal to the closing price on the date of grant, which shall be November 30, 2014, vesting in equal installments quarterly over a period of four (4) years beginning on November 30, 2014 and such options shall expire seven (7) years after the date of grant, unless they expire earlier in accordance with the terms of the GSIP and 20,000 Restricted Stock Units (“RSUs”) vesting in equal installments annually over a period of four (4) years beginning on November 30, 2014. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP.

THE BOARD OF DIRECTORS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

"RESOLVED: To approve, in accordance with Section 272(c1)(1) of the Companies, Law, for Mr. Ken Berlin, the Chief Executive Officer of the Company, a grant of options to purchase up to 100,000 Ordinary Shares of the Company at an exercise price per share equal to the closing price on the date of grant, which shall be November 30, 2014, vesting in equal installments quarterly over a period of four (4) years beginning on November 30, 2014 and such options shall expire seven (7) years after the date of grant, unless they expire earlier in accordance with the terms of the GSIP and 20,000 RSUs vesting in equal installments annually over a period of four (4) years beginning on November 30, 2014. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP.

An affirmative vote of the holders of a majority of the voting power represented and voting on the matter in person or by proxy, shall be required provided that (i) such a majority includes at least a majority of the ordinary shares voted by shareholders who are not controlling shareholders of the Company nor are they shareholders who have a personal interest in the approval of the proposal set forth in Item 6; or (ii) the total number of shares of non-controlling shareholders and non-interested shareholders voted against the proposal in Item 6 must not represent more than two percent (2%) of the total voting rights in the Company. Votes abstaining shall not be taken into account in counting the above-referenced shareholder votes.

A shareholder must inform the Company before the vote (or if voting by Proxy Card, indicate on the proxy card) whether or not such shareholder is a controlling shareholder or has a Personal Interest, and failure to do so disqualifies the shareholder from participating in the vote.

Board of Directors’ Recommendation:

THE BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE “FOR” THE PROPOSED RESOLUTION.

PROPOSAL SEVEN — REPLACEMENT OF SECTION 38 OF THE COMPANY'S ARTICLES OF ASSOCIATION

Background

As of October 15, 2014, Section 38 of the Company’s Article of Association state that the Company's Board shall consist of no less than two (2) nor more than eleven (11). The Company currently has seven (7) members of the Board, two of which are external according to Israeli Companies Law. In addition the majority of the Company's directors are independent as determined by the Company’s Board annually according to NASDAQ rules. Accordingly, the Board is recommending to Shareholders to approve the reduction of the maximum number of possible Directors of the Company to seven (7).

THE BOARD OF DIRECTORS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

“RESOLVED, to replace section 38 of the Company’s Articles of Association with the following: “The Board of Directors of the Company shall consist of not less than two (2) nor more than seven (7) Directors”.

Board of Directors’ Recommendation:

THE BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE “FOR” THE PROPOSED RESOLUTION.

An affirmative vote of a majority of the shares represented and voting at the Annual Meeting in person or by proxy is required for the approval of such resolution.

ADDITIONAL ITEM

PROPOSAL NINE — ELECTION OF MR. NACHUM (HOMI) SHAMIR

Background

Mr. Nachum (Homi) Shamir and Mr. Israel Makov are proposing that the shareholders elect Mr. Nachum (Homi) Shamir as a member of the Board of Directors of the Company. If elected, Mr. Shamir shall serve as a Class II Director of the Company for a term of one year, until the annual general meeting of the Company’s shareholders to be held in 2015 or until such director’s office is vacated in accordance with the Company’s Articles and the Companies Law.

⁷ As the maximum number of directors according to the Company's Articles of Association may be amended, according to Item 7 of the Agenda.

The following information was provided with respect to Mr. Shamir, by Mr. Shamir and Mr. Makov. The Company assumes no responsibility for the correctness of the information below:

Nachum (Homi) Shamir recently retired as President and Chief Executive Officer and a Director of Given Imaging Ltd., holding this position since April 2006. Early this year, Mr. Shamir completed the sale of Given Imaging to Covidien for U.S. $1B. This was the second successful exit for Mr. Shamir who previously sold Scitex Digital Printing Ltd. in 2004 to Eastman Kodak for U.S. $262M. Prior to Joining Given Imaging Ltd., Mr. Shamir served as Corporate Vice President of the Eastman Kodak Company and as the President of Eastman Kodak’s Transaction and Industrial Solutions Group. From June 2003 to January 2004. Mr. Shamir served as a President and Chief Executive Officer of Scitex Corporation (a NASDAQ listed company), following service in various roles in Scitex and its affiliates from 1993. Before joining Scitex, Mr. Shamir held senior management positions at various international companies mainly in the Asia Pacific regions.

Mr. Shamir holds a B.Sc in Agriculture from Hebrew University of Jerusalem and an M.P.A from Harvard University. Mr. Shamir’s I.D. No. is 05220710-7, his address is 252 Pineland Road NW, Atlanta GA 30342, USA, he was born on January 27, 1954 and he holds Israeli and United States’ citizenships.

Should he be elected, Mr. Shamir shall receive remuneration that is equal to the remuneration paid to the other directors of the Company (except for the Chairman of the Board who receives higher remuneration). In accordance with prior resolutions of the Company's Audit Committee, Board and shareholders meetings that were held on October 12, 2012, and On August 5, 2013 each of the Company's directors (except for the Chairman of the Board) is entitled to receive: (1) remuneration in an amount of US $20,000 plus VAT per year, paid in equal quarterly installments, and a director who serves as a member of a Committee formed by the Board shall be entitled to additional annual remuneration of US $7,500 plus VAT per committee, and (2) payment of a participation fee of the higher of: (a) US $250 plus VAT; or (b) the minimal participation fee according to the Companies Law, and the regulations promulgated pursuant thereto (as of the date hereof – US $346.8), for every Board or Board committee meeting including, inter alia, meeting by means of communication (teleconferences) and unanimous written resolutions.

THE DISSIDENTS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

“RESOLVED, to elect Mr. Nachum (Homi) Shamir as a Class II director, to serve for a term of one year, until the 2015 annual general meeting of shareholders.”

An affirmative vote of a majority of the shares represented and voting at the Annual Meeting, on the nomination of directors, in person or by proxy is required for the approval of such resolution.

ADDITIONAL ITEM

As stated above, the Company's Board has received a request from Mr. Nachum (Homi) Shamir and Mr. Israel Makov, who severally allege to hold 1.67% and 1.69% of the Company's outstanding share capital, respectively. This request was based on section 66(b) of the Israeli Companies Law of 1999, according to which one or more shareholder(s) who hold(s) at least 1% of the voting rights in a shareholder meeting, has the right to request that the Board include an item on the agenda of a shareholders meeting, providing that the subject is of a nature suited to be discussed at a meeting of the shareholders. According to said request, and providing there are vacancies in the Board in accordance to the Company's Articles of Association⁸ this Item 10 will be brought to discussion of the shareholders in this upcoming shareholder meeting:

⁸ As the maximum number of directors according to the Company's Articles of Association may be amended, according to Item 7 of the Agenda.

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PROPOSAL TEN — ELECTION OF MR. DORON BIRGER

Background

Mr. Nachum (Homi) Shamir and Mr. Israel Makov are proposing that the shareholders elect Mr. Doron Birger as a member of the Board of Directors of the Company. If elected, Mr. Birger shall serve as a Class I Director of the Company for a term of three years, until the annual general meeting of the Company’s shareholders to be held in 2017 or until such director’s office is vacated in accordance with the Company’s Articles and the Companies Law.

The following information was provided with respect to Mr. Birger, by Mr. Shamir and Mr. Makov. The Company assumes no responsibility for the correctness of the information below:

Doron Birger is the CEO of Doron Birger Management and Consulting and has years of experience of serving on the boards of directors of a variety of publicly-traded companies. Mr. Birger is an active Chairman on the boards of directors of technology companies including BioCep (until 1/14), Sight Diagnostic, MST, IOptima (medical device companies), Sightera/Magisto, and a board member of HBL Hadasit (TASE:HBL) and Icecure (TASE:ICECURE). Mr. Birger was a director of the public companies Given Imaging Ltd. (in which he served as Chairman of the Board of Directors for five years), Elbit Systems, Elbit Ltd., Netvision and Starling as well as Chairman and board member of many private companies in the Elron group. Mr. Birger has served as the President and CEO of Elron (NASDAQ and TASE:ELRNF), a leading high-tech group in Israel. During his term, Elron grew to include 27 companies, three of them publicly traded, focused in the fields of medical devices, communication, software, clean tech and semiconductors. During Mr. Birger’s term, Elron and its group companies Completed 13 “exits” for a total value of more than $1B, five mergers and splits of $600M in value, three public offerings of group companies on Nasdaq and Tel-Aviv Stock Exchange, and hundreds millions dollars of private equity rounds from strategic investors and leading US and Israeli venture capital funds. Mr. Birger holds a M.A and a B.A. degree in Economics from Hebrew University, Jerusalem. Mr. Doron Birger’s I.D. No. is 50538198, he was born on May 25, 1951, his address is 4 Maabaroth Street Haifa, Israel, and he holds Israeli and Lithuanian citizenship.

Should he be elected, Mr. Birger shall receive remuneration that is equal to the remuneration paid to the other directors of the Company (except for the Chairman of the Board who receives higher remuneration). In accordance with prior resolutions of the Company's Audit Committee, Board and shareholders meetings that were held on October 12, 2012, and On August 5, 2013 each of the Company's directors (except for the Chairman of the Board) is entitled to receive: (1) remuneration in an amount of US $20,000 plus VAT per year, paid in equal quarterly installments, and a director who serves as a member of a Committee formed by the Board shall be entitled to additional annual remuneration of US $7,500 plus VAT per committee, and (2) payment of a participation fee of the higher of: (a) US $250 plus VAT; or (b) the minimal participation fee according to the Companies Law, and the regulations promulgated pursuant thereto (as of the date hereof – US $346.8), for every Board or Board committee meeting including, inter alia, meeting by means of communication (teleconferences) and unanimous written resolutions.

In addition, each of the Company's directors (except for the Chairman of the Board who receives higher remuneration) is entitled to receive: (1) options to purchase 24,000 Ordinary Shares, at an exercise price per share equal to the closing price on the date of the shareholders’ meeting approving the nomination of the Director, vesting in equal installments annually over a period of three years beginning on such date and such options shall expire seven years after their date of grant, unless they expire earlier in accordance with the terms of the GSIP, and (2) 5,000 RSUs upon the commencement of each twelve months period in office as a director beginning on the date of the shareholders meeting approving the nomination of the Director. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP, except that the exercise period of the options and RSUs upon termination shall be six months.

THE DISSIDENTS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

“RESOLVED, to elect Mr. Doron Birger as a Class I director, to serve for a term of three years, until the 2017 annual general meeting of shareholders.”

An affirmative vote of a majority of the shares represented and voting at the Annual Meeting in person or by proxy, on the nomination of directors, is required for the approval of such resolution.

ADDITIONAL ITEM

As stated above, the Company's Board has received a request from Mr. Nachum (Homi) Shamir and Mr. Israel Makov, who severally allege to hold 1.67% and 1.69% of the Company's outstanding share capital, respectively. This request was based on section 66(b) of the Israeli Companies Law of 1999, according to which one or more shareholder(s) who hold(s) at least 1% of the voting rights in a shareholder meeting, has the right to request that the Board include an item on the agenda of a shareholders meeting, providing that the subject is of a nature suited to be discussed at a meeting of the shareholders. According to said request, and providing there are vacancies in the Board in accordance to the Company's Articles of Association⁹ this Item 11 will be brought to discussion of the shareholders in this upcoming shareholder meeting:

PROPOSAL ELEVEN — ELECTION OF MR. ORI HERSHKOVITZ

Background

Mr. Nachum (Homi) Shamir and Mr. Israel Makov are proposing that the shareholders elect Mr. Ori Hershkovitz as a member of the Board of Directors of the Company. If elected, Mr. Hershkovitz shall serve as a Class III Director of the Company for a term of two years, until the annual general meeting of the Company’s shareholders to be held in 2016 or until such director’s office is vacated in accordance with the Company’s Articles and the Companies Law.

⁹ As the maximum number of directors according to the Company's Articles of Association may be amended, according to Item 7 of the Agenda.

11

The following information was provided with respect to Mr. Hershkovitz, by Mr. Shamir and Mr. Makov. The Company assumes no responsibility for the correctness of the information below:

Ori Hershkovitz is the managing partner and head of research for the Sphera fund, Israel’s biggest hedge fund managing over $450M in assets. Mr. Hershkovitz has extensive knowledge in “standard of care” and the knowledge on promising upcoming therapeutics in all medicine fields. He was Senior Pharmaceutical equity analyst in Leader & Co. Investment House Ltd., one of the Israel’s largest underwriters, and voted as best analyst in Israel (2004-2005). Mr. Hershkovitz conducted daily business with domestic and international institutional clients, conducted credit analysis of companies and advised on structured products and M&A activity for the group. He has years of experience of serving on the boards of the variety of publicly-traded companies, including Medigus Ltd. and Micromedic Technologies Ltd. Mr. Hershkovitz holds a B.A in Business Administration and Finance from Tel-Aviv University and is a licensed investment advisor by the Israel Securities Authority. Mr. Ori Hershkovitz’s I.D. No. is 027177500, he was born on July 25 1974, his address is 32 Shimon Hatarsi Street, Apt.6, Tel-Aviv Israel and he holds an Israeli citizenship.

Should he be elected, Mr. Hershkovitz shall receive remuneration that is equal to the remuneration paid to the other directors of the Company (except for the Chairman of the Board who receives higher remuneration). In accordance with prior resolutions of the Company's Audit Committee, Board and shareholders meetings that were held on October 12, 2012, and On August 5, 2013 each of the Company's directors (except for the Chairman of the Board) is entitled to receive: (1) remuneration in an amount of US $20,000 plus VAT per year, paid in equal quarterly installments, and a director who serves as a member of a Committee formed by the Board shall be entitled to additional annual remuneration of US $7,500 plus VAT per committee, and (2) payment of a participation fee of the higher of: (a) US $250 plus VAT; or (b) the minimal participation fee according to the Companies Law, and the regulations promulgated pursuant thereto (as of the date hereof – US $346.8), for every Board or Board committee meeting including, inter alia, meeting by means of communication (teleconferences) and unanimous written resolutions.

In addition, each of the Company's directors (except for the Chairman of the Board who receives higher remuneration) is entitled to receive: (1) options to purchase 24,000 Ordinary Shares, at an exercise price per share equal to the closing price on the date of the shareholders’ meeting approving the nomination of the Director, vesting in equal installments annually over a period of three years beginning on such date and such options shall expire seven years after their date of grant, unless they expire earlier in accordance with the terms of the GSIP, and (2) 5,000 RSUs upon the commencement of each twelve months period in office as a director beginning on the date of the shareholders meeting approving the nomination of the Director. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP, except that the exercise period of the options and RSUs upon termination shall be six months.

THE DISSIDENTS WILL PRESENT THE FOLLOWING RESOLUTION AT THE MEETING:

“RESOLVED, to elect Mr. Ori Hershkovitz as a Class III director, to serve for a term of two years, until the 2016 annual general meeting of shareholders.”

An affirmative vote of a majority of the shares represented and voting at the Annual Meeting in person or by proxy, on the nomination of directors, is required for the approval of such resolution.

ADDITIONAL REQUIRED DISCLOSURES

According to section 4(d) of the Companies Regulations (Notification of general assemblies and by-type assemblies in a public company and adding an item to the agenda), 2000, the following table presents information regarding compensation actually received by our five most highly paid executive officers during the year ended December 31, 2013 (in USD):

Name and position Salary Employer 401K* Vehicle Expenses Pension** Bonus paid Equity*** Total

Mr. Ken Berlin
Chief Executive Officer 500,000 7,770 18,000 - - 608,084 1,133,854

Dr. Robert Wassman
Chief Medical Officer 290,000 7,650 - - 15,000 - 312,650

Mr. Oded Biran
Chief Legal Officer 196,302 - 14,292 12,160 41,143 - 263,897

Mr. Ron Kalfus
Chief Financial Officer 145,926 - 14,210 20,987 20,000 - 201,123

Ms. Dganit Bar
Chief Science Officer 130,574 - 11,672 21,901 - - 164,147

* 401K – in the U.S., this is the tax-qualified, defined-contribution pension account defined in subsection 401(k) of the Internal Revenue Code.

** Pension is for provided for Israel based employees only.

*** Equity is calculated as the value of options awarded, at the time of grant.

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WHERE YOU CAN FIND ADDITIONAL INFORMATION

We are subject to the information reporting requirements of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), applicable to foreign private issuers and fulfill these requirements by filing reports with the SEC. You may read and copy any document we file with the SEC at the SEC’s Public Reference Room at 100 F Street, N.E., Washington, D.C. 20549. You may call the SEC at 1-800-SEC-0330 for further information about the SEC’s public reference room. Our SEC filings are also available to the public at the SEC’s website at www.sec.gov and through the “Investors – SEC Filing” section of our website at www.rosettagenomics.com.

As a foreign private issuer, we are exempt from the rules under the Exchange Act related to the furnishing and content of proxy statements. The filing of the Supplemental Notice of Meeting and this Supplemental Proxy Statement as an exhibit to a Report on Form 6-K with the SEC should not be taken as an admission that we are subject to the proxy rules under the Exchange Act.

By order of the Board of Directors,

/s/ Brian A. Markison

Brian A. Markison

Chairman of the Board

13

ANNUAL GENERAL MEETING OF SHAREHOLDERS OF

ROSETTA GENOMICS LTD.

Company no. 51-292138-8

10 Plaut St., Rabin Science Park

Rehovot, 76706

Israel

Phone number +972-73-222-0700

Date of Annual General Meeting-November 5, 2014

SUPPLEMENTAL NOTICE OF INTERNET AVAILABILITY OF PROXY MATERIAL

The supplemental notice of meeting, proxy statement and proxy card

are available at www.rosettagenomics.com

Please sign, date and mail

your proxy card as soon

as possible.

The record date for determining the shareholders entitled to vote at the Annual Meeting

the close of trading on September 30, 2014

Please detach along perforated line and mail

UNLESS A DULY EXECUTED SUPPLEMENTAL PROXY CARD DETAILING A SHAREHOLDER’S VOTE ON ITEMS 9 THROUGH 11 IS RECEIVED IN ACCORDANCE WITH THE ABOVE, A PROXY CARD IN THE FORM THAT WAS PUBLISHED BY THE COMPANY ON OCTOBER 1, 2014, PRIOR TO THE ADDITION OF ITEMS TO THE AGENDA ACCORDING TO THE SHAREHOLDERS’ REQUEST, AS STATED IN THE SUPPLEMENTAL NOTICE AND PROXY STATEMENT, WILL REMAIN VALID AND SAID SHAREHOLDER’S VOTES WILL BE CONSIDERED AS ABSTAINING VOTES ON ITEMS 9 THROUGH 11 TO THE SUPPLEMENTAL PROXY CARD.

PLEASE SIGN, DATE AND RETURN PROMPTLY.
PLEASE MARK YOUR VOTE IN BLUE OR BLACK INK AS SHOWN HERE

THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO SPECIFIC INSTRUCTION IS GIVEN WITH RESPECT TO THE MATTER TO BE ACTED ON - THE SHARES REPRESENTED BY A SIGNED PROXY CARD WILL BE VOTED AS "ABSTAIN" FOR EACH PROPOSAL'. FOR AGAINST ABSTAIN DO YOU HAVE
ANY
"PERSONAL
INTEREST" IN
THE MATTER¹ ARE YOU A
CONTROLLING
SHAREHOLDER¹

YES NO YES NO

Please sign, date and promptly return this proxy. 1.   To re-elect Mr. Brian Markison, as a Class I director, for a three year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association. ¨ ¨ ¨

2.   To re-elect Dr. Yitzhak Peterburg, as a Class I director, for a three year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association. ¨ ¨ ¨

3.   To approve of the re-appointment of Kost, Forer, Gabbay & Kasierer, a member firm of Ernst & Young Global (“KFGK”), as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2014, and until the next Annual Meeting, and to authorize the Audit committee and the Board of Directors of the Company to determine the remuneration of KFGK in accordance with the volume and nature of their services. ¨ ¨ ¨

4.   To approve the addition of 900,000 ordinary shares, nominal (par) value NIS 0.6 each, to the shares authorized for issuance under the Company’s Global Share Incentive Plan (“GSIP”), so that the total number of Ordinary Shares authorized for issuance under the GSIP will equal 1,803,739. ¨ ¨ ¨

5.   To approve, effective as of January 1, 2014, in accordance with Section 272(c1)(1) of the Israeli Companies, Law, 5759-1999 (the "Companies Law"), of an extension, to the amendment dated June 3, 2012 of the employment agreement of Mr. Ken Berlin, the Chief Executive Officer of the Company. According to such amendment, the CEO is entitled to a base salary at the annual rate of $500,000 USD, payable bi-weekly or otherwise in accordance with the payroll policy of the Company, set to expire at the Company’s 2015 Annual Shareholder Meeting. ¨ ¨ ¨ ¨ ¨ ¨ ¨

6.   Approval, in accordance with Section 272(c1)(1) of the Companies, Law, for Mr. Ken Berlin, the Chief Executive Officer of the Company, a grant of options to purchase up to 100,000 shares of the Company at an exercise price per share equal to the closing price on November 30, 2014, vesting in equal installments quarterly over a period of four years beginning on November 30, 2014 and such options shall expire seven years after their date of grant, unless they expire earlier in accordance with the terms of the Company's GSIP and 20,000 Restricted Stock Units (“RSUs”) vesting in equal installments annually over a period of four (4) years beginning on November 30, 2014. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP. ¨ ¨ ¨ ¨ ¨ ¨ ¨

7.   To replace section 38 of the Company's Articles of Association with the following: "The Board of Directors of the Company shall consist of not less than two (2) nor more than seven (7) Directors. ¨ ¨ ¨

8.   Discussion regarding the Consolidated Financial Statements of the Company for the fiscal year ended December 31, 2013

9.   Providing there are available vacancies on the Company's Board of Directors according to Article 38 of the Company's Articles of Association, to elect Mr. Nachum (Homi) Shamir to serve as a Class II director of the Company for a 1 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2015 in accordance with the Company’s Articles of Association. ¨ ¨ ¨

10.  Providing there are available vacancies on the Company's Board of Directors according to Article 38 of the Company's Articles of Association, to elect Mr. Doron Birger to serve as a Class I director of the Company for a 3 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association. ¨ ¨ ¨

                                      11.  Providing there are available vacancies on the Company's Board of Directors according to Article 38 of the Company's Articles of Association, to elect Mr. Ori Hershkovitz to serve as a Class III director of the Company for a 2 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2016 in accordance with the Company’s Articles of Association. ¨ ¨ ¨

Please sign exactly as your name or names appear on this Proxy.  When shares are held jointly, each holder should sign.  When signing as executor, administrator, attorney, trustee or guardian, please give full title as such.  If the signer is a corporation, please sign full corporate name by duly authorized officer, giving full title as such.  If signer is a partnership, please sign in partnership name by authorized person.

Dated:__________________________, 2014

______________________________Signature

_____________________________________

Signature

¹ A shareholder must inform the Company before the vote (or if voting by proxy, indicate on the proxy card) whether or not such shareholder has a Personal Interest and whether or not such Shareholder is a "controlling shareholder", and failure to do so disqualifies the shareholder from participating in the vote.

According to the Companies Law a shareholder will be deemed to have a personal interest if he or she has personal interest in an act or transaction of the company, including a personal interest of his or her relative or of a corporate body in which that person or a relative of that person is a holder of 5% or more of that corporate body’s outstanding shares or voting rights, is a director or general manager, or in which he or she has the right to appoint at least one director or the general manager. For that matter according to the Companies Law - “Personal interest” does not apply to a personal interest stemming merely from the fact that the office holder is also a shareholder in the company. In addition, the term “personal interest” also includes the personal interest of a person voting under a proxy given by another person, even if such appointing person has no personal interest in the proposed act or transaction. In addition, the vote of a person voting under a proxy given by a person having a personal interest in the proposed act or transaction, even if the person voting under the proxy has no personal interest, shall be deemed as a vote made by a person having a personal interest in the proposed act or transaction. The Companies Law defines a “relative” as a person’s spouse, sibling, parent, grandparent or descendent, as well as the descendant, sibling or parent of a person’s spouse, or the spouse of any of the foregoing.

According to the Companies Law, a controlling shareholder is any shareholder that has the ability to direct the activities of the company, including a shareholder holding 25% or more of the voting rights if no other shareholder owns more than 50% of the voting rights in the company, but excluding a shareholder whose power derives solely from his or her position on the board of directors or any other position with the company. If two or more shareholders are interested parties in the same transaction, their shareholdings are combined for the purposes of calculating percentages. A shareholder holding 50% or more of the voting rights of the Company is presumed to be a controlling shareholder.

ROSETTA GENOMICS LTD.

For the Annual General Meeting of Shareholders

To Be Held On November 5, 2014

THIS SUPPLEMENTAL PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS AND ON BEHALF OF MR. ISRAEL MAKOV AND MR. NACHUM (HOMI) SHAMIR

The undersigned shareholder of Rosetta Genomics Ltd. (the "Company") hereby appoints Oded Biran of the Company, with full power of substitution, the true and lawful attorney, agent and proxy of the undersigned, to vote, as designated on the reverse side, all of the Ordinary Shares of the Company which the undersigned is entitled in any capacity to vote at the Annual General Meeting of Shareholders of the Company to be held at the offices of the Company at 10 Plaut St., Rehovot, Israel  on November 5, 2014 at 10:00 a.m. (ET) and all adjournments and postponements thereof.

The undersigned hereby acknowledges receipt of the Notice of Annual General Meeting and the Proxy Statement accompanying such Notice, revokes any proxy or proxies heretofore given to vote upon or act with respect to the undersigned's shares and hereby ratifies and confirm all that the proxy or their substitutes may lawfully do by virtue hereof.

This proxy when properly executed will be voted in accordance with the manner directed herein by the undersigned shareholder.

(CONTINUED AND TO BE SIGNED ON REVERSE SIDE)

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Name and position	Salary		Employer 401K*		Vehicle Expenses		Pension**		Bonus paid		Equity***		Total
Mr. Ken Berlin Chief Executive Officer		500,000		7,770		18,000		-		-		608,084		1,133,854
Dr. Robert Wassman Chief Medical Officer		290,000		7,650		-		-		15,000		-		312,650
Mr. Oded Biran Chief Legal Officer		196,302		-		14,292		12,160		41,143		-		263,897
Mr. Ron Kalfus Chief Financial Officer		145,926		-		14,210		20,987		20,000		-		201,123
Ms. Dganit Bar Chief Science Officer		130,574		-		11,672		21,901		-		-		164,147

PLEASE SIGN, DATE AND RETURN PROMPTLY. PLEASE MARK YOUR VOTE IN BLUE OR BLACK INK AS SHOWN HERE
THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO SPECIFIC INSTRUCTION IS GIVEN WITH RESPECT TO THE MATTER TO BE ACTED ON - THE SHARES REPRESENTED BY A SIGNED PROXY CARD WILL BE VOTED AS "ABSTAIN" FOR EACH PROPOSAL'.		FOR	AGAINST	ABSTAIN	DO YOU HAVE ANY "PERSONAL INTEREST" IN THE MATTER¹		ARE YOU A CONTROLLING SHAREHOLDER¹
					YES	NO	YES	NO
Please sign, date and promptly return this proxy.	1. To re-elect Mr. Brian Markison, as a Class I director, for a three year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association.	¨	¨	¨
	2. To re-elect Dr. Yitzhak Peterburg, as a Class I director, for a three year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association.	¨	¨	¨
	3. To approve of the re-appointment of Kost, Forer, Gabbay & Kasierer, a member firm of Ernst & Young Global (“KFGK”), as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2014, and until the next Annual Meeting, and to authorize the Audit committee and the Board of Directors of the Company to determine the remuneration of KFGK in accordance with the volume and nature of their services.	¨	¨	¨
	4. To approve the addition of 900,000 ordinary shares, nominal (par) value NIS 0.6 each, to the shares authorized for issuance under the Company’s Global Share Incentive Plan (“GSIP”), so that the total number of Ordinary Shares authorized for issuance under the GSIP will equal 1,803,739.	¨	¨	¨

5. To approve, effective as of January 1, 2014, in accordance with Section 272(c1)(1) of the Israeli Companies, Law, 5759-1999 (the "Companies Law"), of an extension, to the amendment dated June 3, 2012 of the employment agreement of Mr. Ken Berlin, the Chief Executive Officer of the Company. According to such amendment, the CEO is entitled to a base salary at the annual rate of $500,000 USD, payable bi-weekly or otherwise in accordance with the payroll policy of the Company, set to expire at the Company’s 2015 Annual Shareholder Meeting.	¨	¨	¨	¨	¨	¨	¨
6. Approval, in accordance with Section 272(c1)(1) of the Companies, Law, for Mr. Ken Berlin, the Chief Executive Officer of the Company, a grant of options to purchase up to 100,000 shares of the Company at an exercise price per share equal to the closing price on November 30, 2014, vesting in equal installments quarterly over a period of four years beginning on November 30, 2014 and such options shall expire seven years after their date of grant, unless they expire earlier in accordance with the terms of the Company's GSIP and 20,000 Restricted Stock Units (“RSUs”) vesting in equal installments annually over a period of four (4) years beginning on November 30, 2014. The options and RSUs are granted and otherwise subject to the same terms and conditions as applicable to options and RSUs granted under the GSIP.	¨	¨	¨	¨	¨	¨	¨
7. To replace section 38 of the Company's Articles of Association with the following: "The Board of Directors of the Company shall consist of not less than two (2) nor more than seven (7) Directors.	¨	¨	¨
8. Discussion regarding the Consolidated Financial Statements of the Company for the fiscal year ended December 31, 2013
9. Providing there are available vacancies on the Company's Board of Directors according to Article 38 of the Company's Articles of Association, to elect Mr. Nachum (Homi) Shamir to serve as a Class II director of the Company for a 1 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2015 in accordance with the Company’s Articles of Association.	¨	¨	¨
10. Providing there are available vacancies on the Company's Board of Directors according to Article 38 of the Company's Articles of Association, to elect Mr. Doron Birger to serve as a Class I director of the Company for a 3 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2017 in accordance with the Company’s Articles of Association.	¨	¨	¨

11. Providing there are available vacancies on the Company's Board of Directors according to Article 38 of the Company's Articles of Association, to elect Mr. Ori Hershkovitz to serve as a Class III director of the Company for a 2 year term commencing on the date of his election at the Annual Meeting and until the Annual General Meeting of the Company’s shareholders to be held in 2016 in accordance with the Company’s Articles of Association.	¨	¨	¨
Please sign exactly as your name or names appear on this Proxy. When shares are held jointly, each holder should sign. When signing as executor, administrator, attorney, trustee or guardian, please give full title as such. If the signer is a corporation, please sign full corporate name by duly authorized officer, giving full title as such. If signer is a partnership, please sign in partnership name by authorized person.

Dated:__________________________, 2014

______________________________Signature
_____________________________________
Signature

ROSETTA GENOMICS LTD.

For the Annual General Meeting of Shareholders
To Be Held On November 5, 2014

THIS SUPPLEMENTAL PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS AND ON BEHALF OF MR. ISRAEL MAKOV AND MR. NACHUM (HOMI) SHAMIR

The undersigned shareholder of Rosetta Genomics Ltd. (the "Company") hereby appoints Oded Biran of the Company, with full power of substitution, the true and lawful attorney, agent and proxy of the undersigned, to vote, as designated on the reverse side, all of the Ordinary Shares of the Company which the undersigned is entitled in any capacity to vote at the Annual General Meeting of Shareholders of the Company to be held at the offices of the Company at 10 Plaut St., Rehovot, Israel on November 5, 2014 at 10:00 a.m. (ET) and all adjournments and postponements thereof.

The undersigned hereby acknowledges receipt of the Notice of Annual General Meeting and the Proxy Statement accompanying such Notice, revokes any proxy or proxies heretofore given to vote upon or act with respect to the undersigned's shares and hereby ratifies and confirm all that the proxy or their substitutes may lawfully do by virtue hereof.

This proxy when properly executed will be voted in accordance with the manner directed herein by the undersigned shareholder.

(CONTINUED AND TO BE SIGNED ON REVERSE SIDE)