Statement of Changes in Beneficial Ownership (4)

X0306 4 2014-08-14 0 0000861838 IDERA PHARMACEUTICALS, INC. IDRA 0001534428 Pillar Invest Corp C/O IDERA PHARMACEUTICALS, INC. 167 SIDNEY STREET CAMBRIDGE MA 02139 1 0 1 0 0001534425 Pillar Pharmaceuticals I LP PILLAR INVEST OFFSHORE SAL, STARCO CTR, BLOC B, 3RD FLOOR, OMAR DAOUK STREET BEIRUT M8 2020-3313 LEBANON 1 0 1 0 0001193366 ZEIN YOUSSEF EL PILLAR INVEST OFFSHORE SAL, STARCO CTR, BLOC B, 3RD FLOOR, OMAR DAOUK STREET BEIRUT M8 2020-3313 LEBANON 1 0 1 0 Common Stock 2014-08-14 4 S 0 400772 0.00 D 0 I See Footnote Common Stock 2014-08-15 4 S 0 215934 0.00 D 0 I See Footnote Common Stock 2014-08-18 4 S 0 383294 0.00 D 0 I See Footnote Common Stock 2014-08-15 4 X 0 1000000 0.00 A 0 I See Footnote Warrants 0.61 2014-08-15 4 X 0 1000000 0.00 D 2013-05-07 2018-05-07 Common Stock 1000000 0 I See Footnote Shares sold by Pillar Pharmaceuticals I, L.P. ("Pillar I"), of which Pillar Invest Corporation ("Pillar GP") is the general partner. Pillar GP disclaims Section 16 beneficial ownership of the securities beneficially owned by Pillar I and this report shall not be deemed an admission that Pillar GP is the Section 16 beneficial owner of any such securities, except to the extent of its pecuniary interest therein, if any, by virtue of its ownership interest in Pillar I. As of the date hereof, Pillar I owns directly 6,296,933 shares of common stock of the Issuer. Youssef El Zein is a director and controlling stockholder of Pillar GP and serves as the representative of a Pillar I and Pillar GP on the Issuer's board of directors. Mr. El Zein disclaims Section 16 beneficial ownership of the securities beneficially owned by Pillar I and this report shall not be deemed an admission that he is the beneficial owners of any such securities, except to the extent of his pecuniary interest therein, if any, by virtue of his ownership interest in Pillar GP. As of the date hereof, Mr. El Zein owns directly 586,101 shares of common stock of the Issuer. Warrants beneficially owned and exercised for shares of common stock by Pillar I, of which Pillar GP is the general partner (the "Pillar I Warrants"). Pillar GP disclaims Section 16 beneficial ownership of the Pillar I Warrants and the common stock underlying such warrants and this report shall not be deemed an admission that Pillar GP is the Section 16 beneficial owner of any such securities, except to the extent of its pecuniary interest therein, if any, by virtue of its ownership interest in Pillar I. /s/ Youssef El Zein, Authorized Person 2014-08-18 /s/ Youssef El Zein 2014-08-18

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