Protokinetix Inc (PK) (PKTX) News

Dearest Old Sun.....I have to laugh......You again will make it up as you go along as you travel down this path.....Enjoy your day.. :+)

"You will makeup things as they come along..."

I think you'll find that's the French Canadian mafiosi behind PKTX - you know, your ole buddies like Jean-Francois and Maximilien.

Dearest Ole Sun.....Take care and don't worry about me.....You will makeup things as they come along... :+)

"another month and there won't be much volume at all with people on vacation"

Another month and there won't be much volume unless PnP and his French Canadian mafiosi paymasters start spoofing some trades.

Yet again..

another month and there won't be much volume at all with people on vacation

Yep, a whole $1000 bucks pissed away on this obvious scam.

There's one born every day.

nice to see it traded up today.

this stock doesnt move with markets, or anything else it has it own agenda, and if it was a full blown scam like some guys on this board are saying, the 20years chart wouldnt look like that, it would be a parabollic downward line with a stock price that was once worth 100000 and now 0,10, and there are stocks like that on the market believe me, for instance TNXP was once worth 20,000,000,000$ per share and is now 17$ per share, that, is a real scam

I can see why this didn't move up today. Freed up cash and bought some more nasdaq stock. Had a feeling it would move faster than this.

Maybe not. French Canadian Mafia futures are down too.

figures this moves up when the market goes down 4/3//25

The bloated CEO of this company has failed investors at every turn....
Now go get your shinebox....

" must be a bureaucratic/digital hassle that make them not changing the status"
That's funny

Dear Folks.. If anyone...Yes anyone has followed Ole Sunspotter.....Twenty, twenty five stocks he rants on.....Take the Subject/Title away.....The body...On any of them..All sound the same...Just him Bitching.....Probably..He's being paid to rant and being Negative on the stock..

spelling error "by 1 PM"

lots of volume again today 190,000 4/2/25 buy 1 PM

"maybe in our graves we will know what's up lol"

I can tell you now, if you like.

They are not recruiting anymore, i know that for a fact. Idk why they don't update the status, must be a bureaucratic/digital hassle that make them not changing the status. But holy hell, can they give a real update on the advancement of this study lmao this is crazy, maybe in our graves we will know what's up lol

One has to wonder how accurate this report is and if a study is actually ongoing

It seems rather odd that recruiting is still open passed the date of the Estimated Study Completion Date

https://clinicaltrials.gov/study/NCT03073577?tab=results

"Patient recruitment is one of the most critical elements of a clinical trial. Without sufficient participation, studies will lack the power to demonstrate the statistical significance and efficacy of new treatments. Ultimately, poor patient enrollment will delay or prevent new therapies from reaching the market."

clinical trials study was due last week . See if they just change the date again like they did two months ago https://clinicaltrials.gov/study/NCT03073577?tab=results

I didn't lose money with SPPH, silly, as you and your French Canadian mafiosi paymasters behind PKTX well know.

I spotted as a scam from the get-go, and the SEC and AMF both (eventually) agreed with me.

Didn't stop your criminal chum SPPH's CEO Max Arella from being on PKTX' Board of Directors for quite a time after the scandal broke though. Your chum Jean-Francois likes the veneer of respectability that a crooked academic gives his scams.

Here's the start of the receipts:

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=56325141

***PKTX.. Well, Well.. Ole Sun is still Kicking.. I guess the back door "Kick back" money is still flowing your way.. All the money you lost with Spencer Pharmaceutical hasn't slowed you down one bit.. you Need to change your businesses from "attacking" to smarter investing.. Enjoy your day ole Wise One..

“ At December 31, 2024, we had a $4,697 shortfall in cash and negative $3,647 in total current assets. As of December 31, 2024, we had a negative working capital equity deficit position of $127,694. Although as of the date of this Annual Report we do not believe we have sufficient capital to meet cash flow projections and carry forward our business objectives in the short-term, the Company will need additional working capital to continue its medical research or to be successful in any future business activities and continue to pay its liabilities. There can be no assurance that in the future we will be able to raise capital from outside sources in sufficient amounts to fund our business.”

By their own admission PKTX is technically and in reality bankrupt.

The legal and fiduciary duty of PKTX’ directors is now to wind the company up ASAP.

Their failure to do so may be related to Mr. Smith and his French Canadian mafiosi employers’ reluctance to kill this particular cash cow.

see what happens next week. I am wondering if the results of the study are coming soon?

interesting to see volume early in the day 3/27/25. 108000

only if they didn't own any before that. If I bought at .008 and sold at .015, the stock I bought years ago at .02 or whatever gets sold for a loss.

Looks like whoever bought a boat load at 0.008 ..... sold last week at 0.015 for a nice, almost 💯, profit !!!

unfortunately, so much for that outlook

kind of a disappointing week for this stock. There was a ton of volume.

I recall thinking that was misleading, especially the headline. The stem cells restored the vision . The AAGP help the stem cells survive.

https://www.protokinetix.com/protokinetix-aagp-restores-vision-in-blind-test-subjects/

I don't recall it curing blindness in mice, but it helped the cells implanted in the eyes thrive instead of disappointing the researchers

Huge potential...already clinically tested and safe on humans...cured blindness in mice...

***PKTX..
Stem Cell Therapy Reverses Diabetes..***

According to a new study published in Science Advances, researchers have developed a novel cell transplantation technique that successfully reversed type 1 diabetes in mice, using human islets vascularized with adaptable endothelial cells for functional subcutaneous engraftment.

Breakthrough in Islet Transplantation
The innovative technique employs human reprogrammed vascular endothelial cells (R-VECs) to functionally vascularize pancreatic islets, addressing a major challenge in islet transplantation therapy1. This approach enables:

In vitro functional vascularization of islets with responsive glucose-stimulated insulin secretion

Successful reversal of hyperglycemia in diabetic mice through subcutaneous transplantation

High levels of human insulin in recipient serum, with hyperglycemia returning upon graft removal

R-VECs, engineered by transiently expressing the vascular-specific transcription factor ETV2, demonstrate remarkable adaptability by self-assembling into perfusable vascular networks and acquiring islet endothelial cell-specific characteristics when cocultured with human islets12. This breakthrough represents a significant step towards improved islet transplantation therapy, potentially offering a path to long-term insulin independence for type 1 diabetes patients34.

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Role of R-VECs in Vascularization
Microenvironmental determinants of endothelial cell ...
Reprogrammed vascular endothelial cells (R-VECs) play a crucial role in enhancing islet transplantation outcomes by providing robust vascularization. Their unique properties and adaptability make them particularly effective for supporting islet survival and function:

R-VECs form extensive vascular networks that arborize and penetrate islets, mimicking native pancreatic vasculature12

When co-cultured with islets, R-VECs acquire islet endothelial cell-specific characteristics, demonstrating remarkable adaptability34

R-VEC-formed blood vessels have larger diameters (13.5 ± 7.5 µm) compared to native human islet capillaries (6.8 ± 2.1 µm), potentially improving blood flow1

Cotransplanted R-VECs contribute substantially more to islet vascularization than host endothelial cells in subcutaneous transplants1

The vascular network formed by R-VECs successfully anastomoses with host circulation, ensuring long-term graft survival31

This advanced vascularization technique addresses a major challenge in islet transplantation, potentially improving graft survival and function while enabling transplantation in more accessible sites like the subcutaneous space.

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Subcutaneous Transplantation Success
Subcutaneous transplantation of vascularized islets marks a significant advancement in type 1 diabetes treatment. This site offers several advantages, including a large surface area, easy accessibility for transplantation and monitoring, and potential graft retrieval if necessary1. Previous attempts at subcutaneous islet transplantation had failed due to insufficient vascularization, but the use of R-VECs overcomes this challenge by forming blood vessels that arborize and vascularize the islets, effectively connecting with the host circulation23.

Transplanted R-VECs form functional blood vessels that support islet survival

Subcutaneous site allows for non-invasive monitoring and potential graft removal

Successful reversal of hyperglycemia in diabetic mice demonstrates the technique's efficacy12

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Implications for Type 1 Diabetes
This innovative approach addresses several key challenges in islet transplantation therapy, including the scarcity of donor organs and islet loss due to disconnection from extracellular matrix and vasculature during isolation1. By enabling effective vascularization, the technique potentially reduces inflammatory and rejection reactions that compromise islet survival1. Importantly, this method may pave the way for transplantation without the need for lifelong immunosuppression, a significant drawback of conventional approaches2. The success of this technique in animal models represents a promising step towards translating this therapy to human patients, offering hope for a more effective and durable treatment for type 1 diabetes34.

https://www.perplexity.ai/page/stem-cell-therapy-reverses-dia-clGsnmywR4ugK

This one may have potential....What is the OS?

Yeah but still very interesting to see a successful therapy using islet transplant to cure diabetes 1, which is making headlines.. And it's making headlines while it was conducted on mices, PKTX study is on human beings, much more impactful

they don't mention anything obvious specifically about AAGP or any companies. though. Could be all sorts of other research involved in islets transplantation.

Look at this guys, this is our time to shine !!!

***PKTX.. Dearest Ole Sun.. Have a Good Day and go back to sleep.. :+)

With volume like today’s so far, how could it fail?

it's got to reach .05 first : )

Company gonna get bought out ...... at $0.05 per share.

.0142 with nice bid support!

NEWS COMING!!!!!

your attitude seems to have changed

News coming!

Close at or above.015

surprised there isn't more insider buying if something is going on that's positive

see what happens next week.

News coming????
Watch for a jump in PPS

nice volume and a tiny increase in price