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      6. Vir Biotechnology Inc (VIR) Quote

      Vir Biotechnology Inc

      Vir Biotechnology Inc (VIR)

      Vidrala SA
      7.38
      0.04
      (0.54%)
      Closed December 24 4:00PM
      Delayed by 15 minutes
      7.45
      0.07
      ( 0.95% )
      Pre Market: 4:56AM
      Delayed by 15 minutes

      Professional-Grade Tools, for Individual Investors.

      Premium

      Key stats and details

      Current Price
      7.45
      Bid
      7.39
      Ask
      8.50
      Volume
      100
      0.00 Day's Range 0.00
      6.56 52 Week Range 13.09
      Market Cap
      1.026B
      Previous Close
      7.38
      Open
      -
      Last Trade
      100
      @
      7.45
      (formt)
      Last Trade Time
      04:56:11
      Financial Volume
      -
      VWAP
      -
      Average Volume (3m)
      1,275,080
      Shares Outstanding
      137,720,120
      Dividend Yield
      -
      PE Ratio
      -1.65
      Earnings Per Share (EPS)
      -4.47
      Revenue
      86.18M
      Net Profit
      -615.06M

      About Vir Biotechnology Inc

      Vir Biotechnology Inc is a commercial-stage immunology company focused on treating and preventing infectious diseases. It has four technology platforms, focused on antibodies, T cells, innate immunity, and small interfering ribonucleic acid, or siRNA, through internal development, collaborations, an... Vir Biotechnology Inc is a commercial-stage immunology company focused on treating and preventing infectious diseases. It has four technology platforms, focused on antibodies, T cells, innate immunity, and small interfering ribonucleic acid, or siRNA, through internal development, collaborations, and acquisitions. The company's pipeline consists of product candidates targeting hepatitis B virus, or HBV, influenza A, human immunodeficiency virus, or HIV, and tuberculosis, or TB. Its revenue sources are collaboration revenue, contract revenue, grant revenue and license revenue. Show more

      Sector
      Biological Pds,ex Diagnstics
      Industry
      Biological Pds,ex Diagnstics
      Website
      www.vir.bio
      Headquarters
      Wilmington, Delaware, USA
      Founded
      -
      Vir Biotechnology Inc is listed in the Biological Pds,ex Diagnstics sector of the NASDAQ with ticker VIR. The last closing price for Vir Biotechnology was $7.38. Over the last year, Vir Biotechnology shares have traded in a share price range of $ 6.56 to $ 13.09.

      Vir Biotechnology currently has 137,720,120 shares outstanding. The market capitalization of Vir Biotechnology is $1.02 billion. Vir Biotechnology has a price to earnings ratio (PE ratio) of -1.65.

      Ask ADVFN Intelligence (AI)

      VIR Latest News

      More News

      Vir Biotechnology to Present at the 43rd Annual J.P. Morgan Healthcare Conference

      Vir Biotechnology Inc. (NASDAQ: VIR) today announced that Marianne De Backer, M.Sc., Ph.D., MBA, Chief Executive Officer, will present at the 43rd Annual J.P. Morgan Healthcare Conference on...

      December 18 2024
      Business Wire

      Vir Biotechnology Receives FDA Breakthrough Therapy Designation and EMA PRIME Designation for Tobevibart and Elebsiran in Chronic Hepatitis Delta

      – Designations aim to expedite the development and review of promising therapies for serious conditions with unmet medical needs – – Phase 3 ECLIPSE registrational program in chronic hepatitis...

      December 12 2024
      Business Wire

      Form 4 - Statement of changes in beneficial ownership of securities

      December 04 2024
      Edgar (US Regulatory)

      Form 144 - Report of proposed sale of securities

      December 02 2024
      Edgar (US Regulatory)

      Vir Biotechnology to Host Virtual Investor Event on PRO-XTEN™ Masked T-Cell Engager Programs

      Vir Biotechnology, Inc. (NASDAQ:VIR) today announced it will host a virtual investor event to discuss initial data from the dual-masked Phase 1 T-cell engagers VIR-5818 targeting a variety of...

      November 26 2024
      Business Wire

      Vir Biotechnology to Participate in the 7th Annual Evercore ISI HealthCONx Conference

      Vir Biotechnology Inc. (NASDAQ: VIR) today announced that Marianne De Backer, M.Sc., Ph.D., MBA, Chief Executive Officer, is scheduled to participate in a fireside chat at the 7th Annual Evercore...

      November 25 2024
      Business Wire

      Vir Biotechnology Presents Positive Chronic Hepatitis Delta Clinical Trial Data and Announces Initiation of Phase 3 Registrational Program

      – Monthly tobevibart and elebsiran combination achieves rapid 100% virologic suppression at Week 24, sustained through Week 60 – – Undetectable HDV RNA in 41% of participants at Week 24...

      November 18 2024
      Business Wire

      Vir Biotechnology Receives Positive Opinion on Orphan Drug Designation for Tobevibart and Elebsiran in Chronic Hepatitis Delta from European Medicines Agency

      – Orphan designation in E.U. supports development of treatments for life-threatening or chronically debilitating conditions with significant unmet medical need – – Phase 2 SOLSTICE 24-week...

      November 18 2024
      Business Wire

      Form 4 - Statement of changes in beneficial ownership of securities

      November 18 2024
      Edgar (US Regulatory)

      Vir Biotechnology Announces Positive End-of-Treatment Results for Tobevibart and Elebsiran Combinations in Chronic Hepatitis B from the MARCH Study at AASLD The Liver Meeting

      – 39% of participants with low baseline Hepatitis B surface antigen (HBsAg) achieved HBsAg loss with tobevibart + elebsiran, and 46% with tobevibart + elebsiran + pegylated interferon alfa – – No...

      November 15 2024
      Business Wire
      PeriodChangeChange %OpenHighLowAvg. Daily VolVWAP
      10.2553.544127866577.1957.567.0414722457.34833923CS
      4-0.36-4.609475032017.819.957.02515160617.98956604CS
      12-0.12-1.585204755617.5710.446.5612750808.09772852CS
      26-1.89-20.23554603859.34116.5610292758.35101404CS
      52-2.72-26.745329400210.1713.096.5610671959.19678312CS
      156-33.67-81.882295719841.1242.546.56114490317.76843691CS
      260-5.21-41.153238546612.66141.016.56116208228.10800788CS

      VIR - Frequently Asked Questions (FAQ)

      What is the current Vir Biotechnology share price?
      The current share price of Vir Biotechnology is $ 7.45
      How many Vir Biotechnology shares are in issue?
      Vir Biotechnology has 137,720,120 shares in issue
      What is the market cap of Vir Biotechnology?
      The market capitalisation of Vir Biotechnology is USD 1.02B
      What is the 1 year trading range for Vir Biotechnology share price?
      Vir Biotechnology has traded in the range of $ 6.56 to $ 13.09 during the past year
      What is the PE ratio of Vir Biotechnology?
      The price to earnings ratio of Vir Biotechnology is -1.65
      What is the cash to sales ratio of Vir Biotechnology?
      The cash to sales ratio of Vir Biotechnology is 11.79
      What is the reporting currency for Vir Biotechnology?
      Vir Biotechnology reports financial results in USD
      What is the latest annual turnover for Vir Biotechnology?
      The latest annual turnover of Vir Biotechnology is USD 86.18M
      What is the latest annual profit for Vir Biotechnology?
      The latest annual profit of Vir Biotechnology is USD -615.06M
      What is the registered address of Vir Biotechnology?
      The registered address for Vir Biotechnology is 251 LITTLE FALLS DRIVE, WILMINGTON, DELAWARE, 19808
      What is the Vir Biotechnology website address?
      The website address for Vir Biotechnology is www.vir.bio
      Which industry sector does Vir Biotechnology operate in?
      Vir Biotechnology operates in the BIOLOGICAL PDS,EX DIAGNSTICS sector

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      VIR Discussion

      View Posts
      Monksdream Monksdream 4 days ago
      VIR under $8
      👍️0
      DewDiligence DewDiligence 2 months ago
      VIR reports 3Q24 results—9/30/24 cash=$1.19B:

      https://www.businesswire.com/news/home/20241031806056/en
      👍️0
      Monksdream Monksdream 2 months ago
      VIR under $10
      👍️0
      TheFinalCD TheFinalCD 5 months ago
      https://x.com/NuntioBot/status/1819101232079786025

      https://finviz.com/quote.ashx?t=VIR&p=d#google_vignette

      Message in reply to:
      VIR pares pipeline—reduces workforce 25%:

      https://investors.vir.bio/news/news-details/2024/Vir-Biotechnology-Reports-Second-Quarter-2024-Financial-Results-and-Announces-Strategic-Restructuring-to-Prioritize-Clinical-Stage-Pipeline-Opportunities/default.aspx

      VIR has terminated its programs in flu, COVID, and T cell-based viral vectors.

      VIR also announced a collaboration with SNY to develop T-cell engagers (https://investors.vir.bio/news/news-details/2024/Vir-Biotechnology-Acts-on-Expanded-Strategy-of-Powering-the-Immune-System-Through-Exclusive-Worldwide-License-Agreement-with-Sanofi-for-Multiple-Potential-Best-in-Class-Clinical-Stage-T-cell-Engagers/default.aspx ), but financial terms of the collaboration were not disclosed.


      2Q24 CC slides:
      https://s203.q4cdn.com/628578897/files/doc_presentations/2024/Jul/Vir-Corporate-Presentation_Q2-2024.pdf
      👍️0
      DewDiligence DewDiligence 5 months ago
      VIR pares pipeline—reduces workforce 25%:

      https://investors.vir.bio/news/news-details/2024/Vir-Biotechnology-Reports-Second-Quarter-2024-Financial-Results-and-Announces-Strategic-Restructuring-to-Prioritize-Clinical-Stage-Pipeline-Opportunities/default.aspx

      VIR has terminated its programs in flu, COVID, and T cell-based viral vectors.

      VIR also announced a collaboration with SNY to develop T-cell engagers (https://investors.vir.bio/news/news-details/2024/Vir-Biotechnology-Acts-on-Expanded-Strategy-of-Powering-the-Immune-System-Through-Exclusive-Worldwide-License-Agreement-with-Sanofi-for-Multiple-Potential-Best-in-Class-Clinical-Stage-T-cell-Engagers/default.aspx ), but financial terms of the collaboration were not disclosed.


      2Q24 CC slides:
      https://s203.q4cdn.com/628578897/files/doc_presentations/2024/Jul/Vir-Corporate-Presentation_Q2-2024.pdf
      👍️0
      Monksdream Monksdream 5 months ago
      VIR under $11
      👍️0
      Monksdream Monksdream 6 months ago
      VIR under $10
      👍️0
      DewDiligence DewDiligence 7 months ago
      VIR +18% on phase-2 HDV data at EASL:

      https://finance.yahoo.com/news/tobevibart-monotherapy-combination-therapy-elebsiran-093000369.html

      Note: HDV is a subset of HBV insofar as HDV resides within HBV’s capsid.
      👍️0
      DewDiligence DewDiligence 8 months ago
      VIR 1Q24 CC transcript:

      https://finance.yahoo.com/news/vir-biotechnology-inc-nasdaq-vir-170535096.html
      👍️0
      Monksdream Monksdream 8 months ago
      VIR still reversing off the recent 52 week low
      👍️0
      DewDiligence DewDiligence 8 months ago
      VIR reports 1Q24 results—3/31/24 cash=$1.51B(!):

      https://www.businesswire.com/news/home/20240502260564/en

      VIR re-iterated guidance for 2024 operating expenses of $650-680M.

      CC slides:
      https://investors.vir.bio/files/doc_financials/2024/q1/Vir-Corporate-Presentation_Q1-2024.pdf
      👍️0
      Monksdream Monksdream 8 months ago
      VIR under $10
      👍️0
      DewDiligence DewDiligence 8 months ago
      VIR adds two luminaries to BoD:

      https://www.businesswire.com/news/home/20240418098064/en

      The capsule bios in the PR speak for themselves.
      👍️0
      DewDiligence DewDiligence 10 months ago
      VIR 4Q23 CC transcript:

      https://finance.yahoo.com/news/q4-2023-vir-biotechnology-inc-185403667.html
      👍️ 1
      DewDiligence DewDiligence 10 months ago
      VIR 4Q23 CC slides:

      https://investors.vir.bio/files/doc_presentations/2024/02/22/Vir-Corporate-Presentation_Q4-2023.pdf
      👍️0
      DewDiligence DewDiligence 10 months ago
      VIR reports 4Q23 results—issues 2024 expense guidance:

      https://www.businesswire.com/news/home/20240222740501/en

      12/31/23 cash was $1.63B, after burning $108M during 4Q23.

      2024 guidance for SG&A + R&D GAAP expenses is $650-680M.

      At the current share price, VIR has an enterprise value of roughly negative $200M.
      👍️0
      DewDiligence DewDiligence 10 months ago
      VIR’s CMO left the company, which explains the exercise-and-hold transaction from January in the post I'm replying to:

      https://finance.yahoo.com/news/vir-biotechnology-announces-dr-phil-213000676.html

      Note: The above was issued on 2/20/24.
      👍️0
      DewDiligence DewDiligence 10 months ago
      GSK, VIR terminate flu collaboration inked in 2021:

      https://www.sec.gov/ixviewer/ix.html?doc=/Archives/edgar/data/0001706431/000162828024006346/vir-20240221.htm

      This outcome is not surprising outcome insofar as the phase-2 trial of VIR-2484, the lead compound of the collaboration, was a failure ( #msg-172395320).
      👍️0
      DewDiligence DewDiligence 12 months ago
      VIR’s CMO exercised and held ~$800K of stock yesterday:

      https://www.sec.gov/Archives/edgar/data/1706431/000162828024000169/xslF345X05/wk-form4_1704311270.xml

      The options in question did not expire until 2027-2028.
      👍️0
      DewDiligence DewDiligence 1 year ago
      VIR cuts workforce 12%:

      https://www.businesswire.com/news/home/20231213396441/en

      It’s bizarre to see belt-tightening by a company with $1.7B of net cash (https://www.sec.gov/ix?doc=/Archives/edgar/data/0001706431/000162828023036702/vir-20230930.htm#i4ba948c416a6412b946073491455ca74_19 ), but it’s probably the right thing to do inasmuch as the stock’s EV is deeply negative.
      👍️0
      harry crumb harry crumb 1 year ago
      Nice move today
      👍️0
      DewDiligence DewDiligence 1 year ago
      VIR -45% on phase-2 failure in influenza:

      https://finance.yahoo.com/news/vir-biotechnology-announces-topline-data-120000102.html Vir Biotechnology…today announced that the Phase 2 PENINSULA trial evaluating VIR-2482 for the prevention of symptomatic influenza A illness did not meet primary or secondary efficacy endpoints. Why such a steep selloff? One reason is that VIR has tended to present itself to investors as all-powerful and all-knowing, which is perhaps a consequence of having George Scangos as (ex)CEO and having raised a huge amount of capital based on management’s reputation.
      👍️0
      DewDiligence DewDiligence 2 years ago
      VIR starts 4-drug phase-2 HBV trial:

      https://www.globenewswire.com/news-release/2023/05/11/2666740/0/en/Vir-Biotechnology-Announces-First-Patient-Dosed-in-New-Phase-2-Chronic-Hepatitis-B-Virus-Trial-Evaluating-Combinations-of-VIR-2218-VIR-3434-PEG-IFN%CE%B1-and-an-NRTI.html

      The four drugs are: VIR-2218, a siRNA; VIR-3434, a mAb; PEG-IFN; and a (generic) nucleoside.

      A separate phase-2 trial (VIR calls it a “subprotocol”) will test VIR-3434 and a nuke, with and without VIR-2218, in patients who are chronic inactive carriers of the HBV virus. I'm unclear as to whether this second trial is for research purposes or for an addressable commercial market.
      👍️0
      DewDiligence DewDiligence 2 years ago
      48w VIR-2219 +peg-IFN—>31% HBs seroconverion:

      https://www.globenewswire.com/news-release/2022/11/06/2549180/0/en/Vir-Biotechnology-Presents-New-Data-Evaluating-the-Potential-for-VIR-2218-and-VIR-3434-to-Achieve-a-Functional-Cure-for-Chronic-Hepatitis-B-Virus-HBV-Infection.html

      The 31% figure is impressive insofar as peg-IFN by itself has a 48w seroconversion rate of only 5-10%. Of course, a 48w regimen of VIR-2219 + peg-IFN won’t be any easier to tolerate than 48w of peg-IFN monotherapy, so this regimen is still far from the ultimate answer for treating chronic HBV.

      VIR has started testing the triple combination of VIR-2219 (siRNA) + VIR-3434 (mAb) + peg-IFN; initial data are expected in 2H23.
      👍️0
      DewDiligence DewDiligence 3 years ago
      VIR EASL presentations:

      https://www.globenewswire.com/news-release/2022/06/25/2469082/0/en/Vir-Biotechnology-Announces-New-Clinical-Data-From-its-Broad-Hepatitis-B-Program.html

      No CC.
      👍️0
      DewDiligence DewDiligence 3 years ago
      VIR HBV webcast slides:

      https://investors.vir.bio/static-files/7ece44c3-0585-47af-81b4-2199889d6934
      👍️0
      DewDiligence DewDiligence 3 years ago
      VIR -14% on amended Sotrovimab EUA due to Omicron BA.2 variant:

      https://finance.yahoo.com/news/us-food-drug-administration-revises-200400156.html GlaxoSmithKline plc and Vir Biotechnology…today announced that the US Food and Drug Administration has amended the Emergency Use Authorization (EUA) Fact Sheet for sotrovimab, an investigational monoclonal antibody. The FDA has determined that, based on the totality of available evidence, including new live virus data generated by Vir, it is unlikely that the sotrovimab 500 mg dose will be effective against the Omicron BA.2 variant.

      GSK and Vir are preparing a package of data in support of a higher dose of sotrovimab for the Omicron BA.2 subvariant and will be sharing these data with regulatory and health authorities around the world for discussion. This PR was issued after the close, but the market apparently got wind of the FDA decision about 3:45pm ET.
      👍️0
      DewDiligence DewDiligence 3 years ago
      VIR 4Q21 results:

      https://www.globenewswire.com/news-release/2022/02/24/2391890/0/en/Vir-Biotechnology-Provides-Corporate-Update-and-Reports-Fourth-Quarter-and-Full-Year-2021-Financial-Results.html As of December 31, 2021, excluding restricted cash, the Company had approximately $909.5 million in cash, cash equivalents, and investments. Excluding restricted cash and its equity investment in Brii Biosciences, the Company had approximately $766.4 million in cash, cash equivalents and investments.
      👍️0
      DewDiligence DewDiligence 3 years ago
      VIR’s 2022 HBV newsflow:

      https://www.globenewswire.com/news-release/2022/02/24/2391890/0/en/Vir-Biotechnology-Provides-Corporate-Update-and-Reports-Fourth-Quarter-and-Full-Year-2021-Financial-Results.html In 2022, the Company expects data readouts from multiple trials evaluating VIR-2218 and VIR-3434:

      • Initial data from the first cohorts of Phase 2 MARCH (Monoclonal Antibody siRNA Combination against Hepatitis B) trial of VIR-2218 in combination with VIR-3434, are expected in the first half of 2022.

      • Additional data from the Phase 2 trial of VIR-2218 in combination with PEG-IFN-alpha are expected in the first half of 2022.

      • Additional data from the Phase 1 monotherapy trial of VIR-3434 are expected in the first half of 2022.

      • The Company’s collaborator, Brii Biosciences, continues to lead the Phase 2 trial evaluating VIR-2218 in combination with BRII-179, an investigational T cell vaccine, for the potential treatment of chronic HBV infection. Initial data are expected in the second half of 2022. Evidently, there will not be a 2022 readout from the phase-2 trial testing combinations of VIR-2218, GILD’s GS-9688, Vemlidy (TAF), and Opdivo (#msg-167061759, #msg-160854272, #msg-167063133).
      👍️0
      rwwest rwwest 3 years ago
      Up so far on another Biotech down day
      Seems like a good omen.
      👍️0
      DewDiligence DewDiligence 3 years ago
      VIR slide set from JPM:

      https://investors.vir.bio/static-files/7ecf45fb-6918-4cf8-9a02-b8c12183ca4f
      👍️0
      DewDiligence DewDiligence 3 years ago
      VIR/GILD start phase-2 trial testing quadruple regimen of VIR-2218; GS-9688; Opdivo; and Vemlidy (TAF) in (both nuc-suppressed and viremic) HBV patients:

      https://finance.yahoo.com/news/vir-biotechnology-announces-initiation-phase-133000267.html

      I’m not sure why it took almost a year for this trial to begin enrolling patients—the PR announcing the collaboration was issued on 1/12/21.

      Please see #msg-160854272 for background.
      👍️0
      HokieHead HokieHead 3 years ago
      Loaded again. After omicron news all weekend this will be the next MRNA biotech. $75+ by years end for starters imo.
      👍️0
      HokieHead HokieHead 3 years ago
      In $46, omicron play.
      👍️0
      DewDiligence DewDiligence 3 years ago
      VIR starts HBV_combination_trial_of_ VIR-2218 and VIR-3434:

      https://finance.yahoo.com/news/vir-biotechnology-initiates-phase-2-123000780.html The multi-center, open-label Phase 2 trial is designed to evaluate the safety, tolerability and efficacy of the combination of VIR-2218 and VIR-3434 in approximately 90 adult patients (ages 18 to 65) with chronic HBV infection receiving nucleot(s)ide reverse transcriptase inhibitor therapy. Both VIR-2218 and VIR-3434 will be administered via subcutaneous injection at varying dose levels over the course of the trial for a treatment period ranging from four to 20 weeks, and a follow-up period of up to 116 weeks, depending on the dosing cohort.

      …VIR-2218 is an investigational small interfering ribonucleic acid (siRNA) designed to inhibit the production of all HBV proteins (X, polymerase, S and core), which may be acting as immune tolerogens. VIR-3434 is an investigational HBV-neutralizing monoclonal antibody designed to block entry of all 10 genotypes of HBV into hepatocytes, as well as reduce the level of virions and subviral particles in the blood. It has also been Fc engineered to include the XX2 “vaccinal mutation,” allowing it to potentially function as a therapeutic T cell vaccine against HBV. See #msg-164593550, #msg-161217289, and #msg-164599741 for related info.
      👍️0
      DewDiligence DewDiligence 4 years ago
      VIR -6% on VIR-2218 and VIR-3434 monotherapy data presented at EASL:

      https://finance.yahoo.com/news/vir-biotechnology-presents-clinical-data-125000851.html

      CC to discuss these data with investment community at 11am ET.
      👍️0
      level42 level42 4 years ago
      "profound efficacy." Vir Biotechnology and GSK plan to seek emergency use authorization for their experimental COVID-19 antibody therapy after interim data from a study showed 85% reduction in hospitalization and deaths among patients.


      Based on these positive results, Vir and GlaxoSmithKline intend to request Emergency Use Authorization (EUA) for VIR-7831 from the U.S. Food and Drug Administration (FDA) and other international regulators.

      "We are pleased that this unique monoclonal antibody was able to bring such a profound benefit to patients," GlaxoSmithKline chief scientific officer Dr. Hal Barron said. "We look forward to the possibility of making VIR-7831 available to patients as soon as possible."
      👍️0
      interloper interloper 4 years ago
      Too high too fast. Very typical price movement. I you think your gonna ride a rocket to the moon you better be ready when the booster fuel runs out.
      👍️0
      dealerschool2006 dealerschool2006 4 years ago
      why is VIR coming back down???
      👍️0
      rtrstock rtrstock 4 years ago
      Huge disappointment.

      This could go back to under 20.00 pps

      Should have sold at 140.00

      This stock price is just based on hype, the collapse is the reality of things.

      👍️0
      CatBirdSeat CatBirdSeat 4 years ago
      Two New Rockships Taking Off After VIR

      Behold! FNMA & FMCC

      Ka Ching ! Baby! $$$$
      👍️0
      rtrstock rtrstock 4 years ago
      I Should have sold at 140.00

      Now it's in a death spiral.

      Robinhood shows this listing at a completely different price than ihub.
      👍️0
      Srhogan1984 Srhogan1984 4 years ago
      Full of crap haha
      👍️0
      ClayTrader ClayTrader 4 years ago
      * * $VIR Video Chart 01-26-2021 * *

      Link to Video - click here to watch the technical chart video

      👍️0
      Srhogan1984 Srhogan1984 4 years ago
      Sounds like a short to me. You need a bog squeeze? Haha
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      DewDiligence DewDiligence 4 years ago
      Today's move is somewhat scary in the context of #msg-160142077.
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      DewDiligence DewDiligence 4 years ago
      VIR—(+40% undeservedly, IMO)—on_interim_phase-1_data_for VIR-3434_in_HBV:

      https://www.globenewswire.com/news-release/2021/01/26/2164220/0/en/Initial-Data-from-Ongoing-Phase-1-Trial-of-VIR-3434-for-Chronic-Hepatitis-B-Virus-Infection-Demonstrates-Significant-and-Rapid-Reduction-in-Hepatitis-B-Surface-Antigen.html

      The mean reduction in HBsAg (n=6) was 1.3 logs after 8 days. That’s not bad, but neither is it a knock-your-socks-off result. Monotherapy is unlikely to generate a functional cure in HBV, no matter how potent the agent may be against HBsAg.

      VIR-3434 is a monoclonal antibody and is VIR’s second HBV agent in the clinic; the first is VIR-2218, an RNAi agent (#msg-155042587).
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      DewDiligence DewDiligence 4 years ago
      Not really. It's just a phase-2 trial, not a full-fledged partnership.
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      DewDiligence DewDiligence 4 years ago
      GILD, VIR collaborate on phase-2 HBV trial:

      https://www.businesswire.com/news/home/20210112005578/en The companies plan to initiate a Phase 2 trial evaluating combination therapy for both treatment-experienced and treatment-naïve people living with HBV. The multi-arm trial will evaluate different combinations of selgantolimod, Gilead’s investigational TLR-8 agonist; VIR-2218, Vir’s investigational small interfering ribonucleic acid (siRNA); and a commercially-sourced, marketed PD-1 antagonist. People in the trial with HBV treatment experience may also receive Gilead’s Vemlidy (tenofovir alafenamide fumarate, TAF). The primary outcome of the study will be the proportion of patients achieving a functional cure, defined as an off-therapy loss of hepatitis B surface antigen (HBsAg) and HBV DNA from the serum.

      Both companies retain full rights to their individual product candidates and will discuss the potential path forward for any future combination studies based on the outcome of the Phase 2 trial. I.e., no cash is changing hands between the two companies.
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      Srhogan1984 Srhogan1984 4 years ago
      Huge news!
      👍️0

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