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Hillstream BioPharma Inc

Hillstream BioPharma Inc (HILS)

0.2305
0.00
(0.00%)
0.00
0.00
(0.00%)

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Key stats and details

Current Price
0.2305
Bid
0.2305
Ask
0.24
Volume
-
0.00 Day's Range 0.00
0.00 52 Week Range 0.00
Market Cap
Previous Close
0.2305
Open
-
Last Trade
Last Trade Time
Financial Volume
-
VWAP
-
Average Volume (3m)
-
Shares Outstanding
1,486,000
Dividend Yield
-
PE Ratio
-0.17
Earnings Per Share (EPS)
-8.21
Revenue
-
Net Profit
-12.2M

About Hillstream BioPharma Inc

Hillstream BioPharma Inc is a biotechnology company developing novel therapeutic candidates targeting ferroptosis, an emerging new anti-cancer mechanism resulting in iron-mediated cell death for drug-resistant and devastating cancers. Hillstream BioPharma Inc is a biotechnology company developing novel therapeutic candidates targeting ferroptosis, an emerging new anti-cancer mechanism resulting in iron-mediated cell death for drug-resistant and devastating cancers.

Sector
Pharmaceutical Preparations
Industry
Pharmaceutical Preparations
Headquarters
Lewes, Delaware, USA
Founded
-
PeriodChangeChange %OpenHighLowAvg. Daily VolVWAP
10000000CS
40000000CS
120000000CS
260000000CS
520000000CS
1560000000CS
2600000000CS

HILS - Frequently Asked Questions (FAQ)

What is the current Hillstream BioPharma share price?
The current share price of Hillstream BioPharma is $ 0.2305
How many Hillstream BioPharma shares are in issue?
Hillstream BioPharma has 1,486,000 shares in issue
What is the market cap of Hillstream BioPharma?
The market capitalisation of Hillstream BioPharma is USD 342.52k
What is the 1 year trading range for Hillstream BioPharma share price?
Hillstream BioPharma has traded in the range of $ 0.00 to $ 0.00 during the past year
What is the PE ratio of Hillstream BioPharma?
The price to earnings ratio of Hillstream BioPharma is -0.17
What is the reporting currency for Hillstream BioPharma?
Hillstream BioPharma reports financial results in USD
What is the latest annual profit for Hillstream BioPharma?
The latest annual profit of Hillstream BioPharma is USD -12.2M
What is the registered address of Hillstream BioPharma?
The registered address for Hillstream BioPharma is 16192 COASTAL HWY, SUSSEX, LEWES, DELAWARE, 19958
What is the Hillstream BioPharma website address?
The website address for Hillstream BioPharma is www.hillstreambio.com
Which industry sector does Hillstream BioPharma operate in?
Hillstream BioPharma operates in the PHARMACEUTICAL PREPARATIONS sector

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HILS Discussion

View Posts
Monksdream Monksdream 1 month ago
THAR under $2
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glenn1919 glenn1919 2 months ago
THAR..............................................................https://stockcharts.com/h-sc/ui?s=THAR&p=W&b=5&g=0&id=p86431144783
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glenn1919 glenn1919 2 months ago
THAR........https://stockcharts.com/h-sc/ui?s=THAR&p=W&b=5&g=0&id=p86431144783
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81vette 81vette 3 months ago
News,new use for already approved drug,no trials needed,we have seen some of these run well in past.
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81vette 81vette 3 months ago
THAR,this snowball in hell might have a chance,demand growing,nhod and moving a bit freely without ask supply
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81vette 81vette 3 months ago
THAR,770k float,fda news out,I bought 1.43 as lotto,super risky,big spread,fast mover/gapper,hit 2.00 pre-mkt and tanked to 1.2 before open,could run again after-mkt but risky! Shares to short 100k and not dropping,also makes this risky and needs vol surges to continue
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Monksdream Monksdream 4 months ago
THAR reports 2/21
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HoldEm777 HoldEm777 5 months ago
Seems closeโ€ฆ bring on a catalystโ€ฆ.
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ecmoney ecmoney 6 months ago
Picked up a few at $2.2 pre market

Going to hold this one until Wednesday

Ec
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glenn1919 glenn1919 6 months ago
THAR........................https://stockcharts.com/h-sc/ui?s=THAR&p=W&b=5&g=0&id=p86431144783
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subslover subslover 6 months ago
Tharimmune Announces $2.02 Million Private Placement to Advance Development Programs
BRIDGEWATER, NEW JERSEY / ACCESSWIRE / December 6, 2024 / Tharimmune, Inc. (Nasdaq:THAR) ("Tharimmune" or the "Company"), a clinical-stage biotechnology company committed to pioneering therapies in immunology and inflammation, today announced it has entered into a securities purchase agreement to raise gross proceeds of approximately $2.02 million through a private placement.

The agreement includes the issuance of 961,446 shares of common stock (or common stock equivalents) and warrants to purchase up to an additional 480,723 shares of common stock. Each share (or common stock equivalent) is priced at $2.10 and is accompanied by a warrant. The warrants will have an exercise price of $2.031 per share, becoming exercisable six months after issuance and expiring five and one-half years from the date of issuance. The closing of this transaction is expected on or about December 9, 2024, subject to customary closing conditions.

Strategic Investors and Placement Details

The financing was led by Gravitas Capital and SDS Capital Group, alongside other biotechnology-focused private investors. President Street Global served as the exclusive placement agent for the offering, ensuring seamless execution of the transaction.

After deducting placement agent fees and other offering-related expenses, the Company intends to allocate the net proceeds toward clinical development, including advancing its flagship TH104 development program, as well as general working capital.

Advancing Innovation in Biotechnology

This financing reinforces Tharimmune's commitment to advancing its portfolio of therapeutic candidates. TH104, the Company's lead clinical asset, is designed to address chronic pruritus associated with primary biliary cholangitis (PBC), a rare and challenging autoimmune liver disease.

Regulatory Details

The securities in this private placement were offered under Section 4(a)(2) of the Securities Act of 1933, as amended, and Regulation D thereunder. The shares of common stock and underlying warrants are not registered under the Securities Act or state securities laws. The Company has agreed to file a resale registration statement covering these securities to enable their future trading upon registration or qualification under applicable laws.

About Tharimmune

Tharimmune, Inc. is a clinical-stage biotechnology company focused on developing innovative therapies in immunology, inflammation, and oncology. The Company's lead product candidate, TH104, leverages a unique transdermal buccal film technology designed to address inflammatory conditions, including pruritus associated with PBC. Tharimmune is also advancing TH023, an oral TNF-alpha inhibitor, and exploring novel multi-specific biologics targeting solid tumors. Through a licensing agreement with OmniAb, Inc., the Company harnesses cutting-edge antibody discovery platforms to target specified disease markers. Learn more at www.tharimmune.com.

Forward-Looking Statements

Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, contained in this press release, including statements regarding the timing and design of Tharimmune's future Phase 2 trial, Tharimmune's strategy, future operations, future financial position, projected costs, prospects, plans and objectives of management, are forward-looking statements. The words "anticipate," "believe," "continue," "could," "depends," "estimate," "expect," "intend," "may," "ongoing," "plan," "potential," "predict," "project," "target," "should," "will," "would," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying wo
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subslover subslover 7 months ago
Tharimmune Presents Positive Clinical Data at AASLD the Liver Meeting(R) to Support TH104 for Chronic Pruritus in Chronic Liver Disease
Significant correlation shown between blood levels and symptom relief; TH104 was well tolerated with no unexpected treatment-emergent adverse events

Phase 2 preliminary data for chronic pruritus in primary biliary cholangitis expected in 2025

BRIDGEWATER, NJ / ACCESSWIRE / November 18, 2024 / Tharimmune, Inc. (Nasdaq:THAR) ("Tharimmune" or the "Company"), a clinical-stage biotechnology company developing a portfolio of therapeutic candidates in inflammation and immunology, presented new TH104 clinical data at the American Association for the Study of Liver Disease (AASLD) The Liver Meeting® 2024, underway in San Diego from November 15-19. The Phase 1 trial was a single-dose, single-center, open-label, randomized study of TH104 transmucosal buccal film conducted in two cohorts of patients with chronic liver disease (CLD), with the primary outcome of safety and tolerability.

"This presentation at The Liver Meeting expands the audience for encouraging Phase 1 data with our lead candidate TH104," said Randy Milby, CEO of Tharimmune. "We look forward to initiating a Phase 2 multiple-ascending dose trial in the coming months to evaluate TH104 in chronic pruritus in primary biliary cholangitis (PBC) patients, with topline data expected in 2025. In the meantime, we continue to engage with both U.S. and EU regulatory authorities."

Data presented at The Liver Meeting include adverse events (AEs) as well as an assessment of patients' relief of pruritus symptom scores when correlated to pharmacokinetics (PK) of TH104. Patients with cholestatic liver disease and a known history of persistent generalized pruritus for at least 4 weeks prior to screening were included. After an overnight fast of 10 hours, subjects received a single low dose of TH104. Serial blood samples for PK analysis were taken, and patients were monitored for itch severity scores utilizing the Worst-Itch Numerical Rating Scale (WI-NRS), a relevant clinical outcome assessment for pruritus in chronic liver disease, and for itch intensity over a 24-hour period.

Pruritus is common in most liver diseases and the WI-NRS is a validated numerical rating scale displaying 11 numbers ranging from 0, representing "no itch," to 10, representing "worst imaginable itch," and patients are asked to pick the number corresponding to the intensity of their pruritus. Results from multiple large studies support the usefulness and validity of WI-NRS for evaluating change over time in clinical trials. Pearson's correlation coefficient (r) was used to assess the correlation between TH104 concentration (ng/ml) Area Under the Curve (AUC) and the change in WI-NRS score 48 hours after dosing.

This study screened 19 patients and 12 were enrolled with two types of CLD categorized as Child-Pugh A (cohort A) and Child-Pugh B (cohort B). The Child-Pugh score is a system for assessing the prognosis and necessity of transplant in CLD that provides a forecast of the increasing severity of a patient's liver disease and expected survival rate. The score is determined by scoring clinical measures of liver disease and the possibility of eventual liver failure, with Class A indicating mild liver disease and Class B indicating moderate liver disease with one-to-five-year survival rates of 95% and 75%, respectively. There were no patients enrolled in this study with the most severe Child-Pugh C classification.

The correlation coefficient between TH104 AUC and change in itch, r, was 0.7060, with a p-value of 0.0103 and a 95% confidence interval for r of 0.2220 to 0.9108.

Change in Itch Score vs. Pharmacokinetics of TH104
The mean baseline WI-NRS scores in Groups A and B were 4.33 and 6.17, respectively, translating to moderate-to-severe chronic pruritus at the start of the study. The mean baseline itch score for all 12 subjects was 5.25. At one-hour post-dosing with TH104, Group A and Group B had a mean decline in WI-NRS scores of 26.8% and 19.0%, respectively, and continued to decline two hours post-dose by 42.3% and 21.7%, respectively. Both cohorts continued to improve in mean itch scores at the four-hour and eight-hour time points, including the combined total subjects. At 24-hours post dosing, Group A and Group B achieved a mean decline of 30.7% and 35.2%, respectively, in pruritus scores. The mean reduction in itch scores for all 12 subjects 24 hours after a single dose of TH104 was 33.3%.

https://www.accesswire.com/imagelibrary/7ba7268b-85f5-4652-b5fd-20411233e6f8/943818/d035cfd1f0a71840d6ed70e964fa.jpgWI-NRS score over time
A total of two AEs (headache) were reported in two subjects over the course of the study. These AEs were mild and possibly related to study drug, with no serious adverse events reported. There were no deaths or other significant adverse events reported during the entire study. There were no new adverse events during the study, with events correlated with previous studies and a safety profile consistent with the literature for the active ingredient in TH104.

About TH104

TH104 is embedded with nalmefene onto a proprietary transdermal buccal film that easily adheres to the inside of the mouth. This endows TH104 with key features making it an ideal product candidate for multiple liver-related and other pruritogenic inflammatory conditions. The molecule has a dual mechanism of action affecting both the ยต-opioid receptor and the kappa-opioid receptor, as well as potentially inhibiting IL-17 inflammatory cytokine expression. These opioid receptors when stimulated and/or inhibited by the body's natural ligands have been known to be involved in the
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Nealio Nealio 8 months ago
Got the sell for $5.82...got to say, I'm lucky it held that area for a long time this morning in pre-mkt. Has anyone come across a product that can link a Stock Alert to an alarm clock?? lolz
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tw0122 tw0122 8 months ago
Nice one not in it
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subslover subslover 8 months ago
Tharimmune Receives Positive Regulatory Feedback From EMA for TH104 Clinical Program for Chronic Pruritus in Primary Biliary Cholangitis
BRIDGEWATER, NJ / ACCESSWIRE / October 30, 2024 / Tharimmune, Inc. (NASDAQ:THAR) ("Tharimmune" or the "Company"), a clinical-stage biotechnology company developing a portfolio of therapeutic candidates in inflammation and immunology, received positive feedback from a Scientific Advice meeting with the European Medicines Agency (EMA) that included guidance on a planned Phase 2 trial to advance TH104, the Company's lead clinical-stage candidate for moderate-to-severe pruritus in primary biliary cholangitis (PBC).

The EMA interactions specifically focused on both the Phase 2 and Phase 3 clinical program of TH104. Overall, the Agency noted that using Article 10(3), hybrid application, is acceptable and could enable referring to non-clinical and some safety data from the approved products. Regarding non-clinical information provided, the Agency endorsed the strategy presented by the Company and noted that there is no need to conduct additional animal studies and considered human exposure to be adequate to move forward. The Agency found the design and main features of the proposed Phase 2 study overall acceptable with some comments. The Agency also provided general guidance for the design of a future Phase 3 study.

"We are pleased with our interactions with both the FDA and EMA," said Randy Milby, CEO of Tharimmune. "The recent regulatory feedback from the EMA builds on the previous positive interactions with the FDA while providing a roadmap for TH104 for chronic pruritus in PBC, which continues to be a debilitating symptom for patients suffering from this rare condition. The progress with regulatory agencies is a testament to our continued commitment to advance innovative solutions in inflammation and immunology."

The Company plans to initiate a Phase 2 multiple-ascending dose trial in the coming months to assess the safety and tolerability of TH104, which will also assess the change from baseline in itch scores to evaluate chronic pruritus in PBC patients. The Company expects topline data in 2025 and continues to engage with both U.S. and EU regulatory authorities.
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gladeshawk gladeshawk 8 months ago
Making a big move UP on very good news out the last few days. Merger and good news from FDA? Just a FYI for anyone interested. HAWK
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Nealio Nealio 1 year ago
Seems like an overaction sell off; the stock was 700k shares at $5 after RS May 24th, 2024...then they did an ATM for approx 400k shares max (to be sold on as needed basis), and then good news hit for Phase 1 drug trial. And they have been declared in good standing by Nasdaq again with stock price/RS. With the still micro-float, this should move with any event or maybe just because this was overdone selling. How do you see it? I may buy some shares. Popping up today...up 8%
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Nealio Nealio 1 year ago
What is the story with this company? Do they have any value? Any drugs in the pipeline with real potential? How much cash do they have? Must not be enough, they are raising money, but how much do they need to raise?
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gladeshawk gladeshawk 1 year ago
I cannot find any news. Just watching for now. HAWK
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Monksdream Monksdream 1 year ago
THAR new 52 week low
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gladeshawk gladeshawk 1 year ago
I saw $5.48 cross.
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tw0122 tw0122 1 year ago
THAR $5.21 or THOR Thor: The Norse God of Thunder, Lightning and Strength - Greek Mythology..low low floater now
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tw0122 tw0122 1 year ago
Added $4.90s tiny new float
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Laster Laster 1 year ago
Low float. Conference today. News?
Slowly creeping up. Slowly.
But that could change very quickly.
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Renee Renee 1 year ago
THAR: effective May 28,2024 a one for 15 reverse split:

https://hedgefollow.com/upcoming-stock-splits.php
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Monksdream Monksdream 1 year ago
THAR new 52 week low
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tw0122 tw0122 1 year ago
https://ih.advfn.com/p.php?pid=ihm_newsArtView&article=93814750&symbol=N%5ETHAR&hl=1
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gladeshawk gladeshawk 1 year ago
Nice to know but we need some 2024 PRs to get this moving. Lots of potential. You have any 2024 info? TIA for any response. HAWK
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tw0122 tw0122 1 year ago
Time for THAR all in
April 17, 18
2023 BioNJ BioPartnering Conference
Company Presentation In person and 1X1 Meetings
The Palace at Somerset Park
Somerset, NJ 08873
April 25 -27
CPHI North America
Attend in-person
Pennsylvania Convention Center in Philadelphia, PA
May 3- May 4
AFSG 12th Drug Delivery Strategic Summit
Embassy Suites by Hiton Boston at Logan Airport
May 10 & 11
Sidoti Virtual Micro-Cap Conference
Presentation and 1x1
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gladeshawk gladeshawk 1 year ago
Thanks. Always appreciate your input.
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surf1944 surf1944 1 year ago
https://ir.tharimmune.com/events-presentations/

Just waiting for one of those potential rocket news events, there are some upcoming events which could start something moving.
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gladeshawk gladeshawk 1 year ago
This will need a really good PR to get the PPS moving UP. Any idea if something is in the works?
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surf1944 surf1944 1 year ago
https://stockcharts.com/h-sc/ui?s=thar&p=D&yr=0&mn=6&dy=0&id=p38090673899

https://www.barchart.com/stocks/quotes/thar/technical-chart?plot=CANDLE&volume=total&data=DO&density=M&pricesOn=1&asPctChange=0&logscale=1&indicators=BBANDS(20,2);SMA(13);PTP(50);ADX(14);SMA(50);SMACD(12,26,9);RSI(14,100);ACCUM;STOSL(14,3)&sym=CNNA&grid=1&height=500&studyheight=100

https://www.barchart.com/stocks/quotes/thar/opinion

https://finance.yahoo.com/quote/thar/

Hoping for a big move in the coming weeks!
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Triple nickle Triple nickle 1 year ago
Diluted down all day
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Billy75 Billy75 1 year ago
Yeah, think that $50 is the 52 week high.

Was at a THAR luncheon last Tuesday.
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gladeshawk gladeshawk 1 year ago
Maybe my TDA info is wrong, but I do not see $50. HAWK
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Billy75 Billy75 1 year ago
News out. Not sure how to link a pdf
Which is why the pre market action is happening
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Awl416 Awl416 1 year ago
Careful
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Billy75 Billy75 1 year ago
Met the CEO today at a luncheon. Seems like a legit guy. Said he has to June to get this stock up to $1.16 I believe. Phase 1 subjects complete. About to start phase 2 in Euro (around 40 people).

This thing was $51 bucks a year ago. Crazy
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work-n-hard work-n-hard 1 year ago
Item 8.01 Other Events.
As of February 8, 2024, Tharimmune, Inc. had 11,739,676 shares of common stock issued and outstanding.

https://app.quotemedia.com/data/downloadFiling?webmasterId=90423&ref=318044524&type=HTML&symbol=THAR&cdn=0989d1ac3abb24ed1cb40e5c349d0078&companyName=Tharimmune+Inc.&formType=8-K&formDescription=Current+report+pursuant+to+Section+13+or+15%28d%29&dateFiled=2024-02-08
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work-n-hard work-n-hard 1 year ago
https://www.nasdaq.com/press-release/tharimmune-announces-dosing-of-first-patient-in-phase-1-clinical-trial-of-th104-its
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Terpi Terpi 1 year ago
Official OS is 2.5M per recent filing as you mentioned... warrants not part of O/S til converted as I'm sure you know.

Warrants issued at $1 and Tang, the bulk holder of them, is known to turn a profit.
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Terpi Terpi 1 year ago
We are in agreement 🤝 my post was in reference to the dilution tracker link, this "O/S" is not an official O/S but one that by the websites own definition is a "potential" OS which assumes all issued warrants have been converted.

By misrepresenting this as the official O/S this gives the impression that warrants have already been converted and that is deceptive as we simply do not know the answer to that with available information.

Basically, yes we agree, and my post was not referring to what you said (you can see its a reply to a different post)
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work-n-hard work-n-hard 1 year ago
The link in my post, is the most recent filing to quote the number OS. Unless, you have found something more recent, that I missed?
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Terpi Terpi 1 year ago
DT considers warrants part of the O/S which is not the case until they have been exercised.

Hence their use of the word "potential".

This is currently a schrodingers cat scenario.

However, the latest filing shows nowhere near the 17M and 10M numbers.
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work-n-hard work-n-hard 1 year ago
Number of shares of common stock to be outstanding after this offering (1) 2,525,474 shares, or 10,700,474 shares (12,200,474 shares if the underwriter exercises its over-allotment option in full), assuming the exercise for cash of all of the Pre-funded Warrants issued in this offering.

Page 9 ( Proof of the accuracy of the site quoted.) 👌

https://app.quotemedia.com/data/downloadFiling?webmasterId=90423&ref=317895786&type=HTML&symbol=THAR&cdn=78571834fec680ac07cfd4519fc06783&companyName=Tharimmune+Inc.&formType=424B5&formDescription=Prospectus+%5BRule+424%28b%29%285%29%5D&dateFiled=2023-11-29#S1_004
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Golden Cross Golden Cross 1 year ago
After offering DT has 10.70M O/S
https://dilutiontracker.com/app/search/THAR?a=4b547f
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Terpi Terpi 1 year ago
Inaccurate. That was O/S prior to the R/S.

Filing on Dec 4 shows 704K O/S along with roughly 11M prefunded warrants that were sold at $1.00.

Other sources claim the O/S is closer to 2.5M

Either way there is no way it can be 17M after the R/S in November.

Stock price hasn't been close to $1 since warrants closed so likely most of them have not been converted.



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Golden Cross Golden Cross 1 year ago
This is last # I have from filings: 17,511,839 shares from last filing(9-30-23)
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WHITTENHALLJR WHITTENHALLJR 1 year ago
Is that really the OS? Goodness gracious.
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