Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Woodford Investment Management LLP

2. Date of Event Requiring Statement (MM/DD/YYYY) 11/5/2015

3. Issuer Name and Ticker or Trading Symbol

NORTHWEST BIOTHERAPEUTICS INC [NWBO]

(Last) (First) (Middle)

9400 GARSINGTON ROAD

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director ___ X ___ 10% Owner
_____ Officer (give title below) _____ Other (specify below)

(Street)

OXFORD OX4 2NH, X0 00000

(City) (State) (Zip)

5. If Amendment, Date Original Filed (MM/DD/YYYY)

6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common stock, $0.001 par value per share	25915937 ⁽¹⁾	I	See footnote ⁽²⁾
Common stock, $0.001 par value per share	18316679 ⁽³⁾	D

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)

Explanation of Responses:
( 1)	This statement is being filed jointly by Woodford Investment Management LLP ("WIM") and CF Woodford Equity Income Fund (the "Woodford Fund"). Neil Woodford, the Head of Investments for WIM, by virtue of his position as such, may be deemed to beneficially own the reported securities beneficially owned by WIM. Mr. Woodford expressly disclaims beneficial ownership of the reported securities except to the extent of any pecuniary interest therein.
( 2)	WIM is an investment manager for the investment funds (including but not limited to the Woodford Fund) that own the reported securities.
( 3)	These are shares owned directly by the Woodford Fund and indirectly by WIM. WIM is the Manager of the Woodford Fund, and WIM may be deemed to be the beneficial owner of the reported securities beneficially owned by the Woodford Fund. The Woodford Fund may also be deemed to be the beneficial owner of such reported securities because the Management Agreement between the Woodford Fund and WIM may be terminated at any time upon 60 days' or less notice.

Remarks:
*As Head of Compliance and Authorized Signatory for WIM.
**As Head of Compliance and Authorized Signatory for WIM in its capacity as the Manager of the Woodford Fund.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Woodford Investment Management LLP 9400 GARSINGTON ROAD OXFORD OX4 2NH, X0 00000		X
CF Woodford Equity Income Fund 40 DUKES PLACE, LONDON, EC3A 7NH, X0 00000		X

Signatures
/s/ Simon Osborne*		11/16/2015
^** Signature of Reporting Person		Date
/s/ Simon Osborne**		11/16/2015
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.