As filed with the Securities and Exchange Commission on March 12, 2025 |
Registration No. 333-228591 |
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
________________________________
POST-EFFECTIVE AMENDMENT NO. 1 TO FORM F-6
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933 FOR AMERICAN DEPOSITARY
SHARES EVIDENCED BY
AMERICAN DEPOSITARY RECEIPTS
____________
AMARIN CORPORATION
PLC
(Exact name of issuer of deposited securities as
specified in its charter)
____________
N/A
(Translation of issuer’s name into English)
____________
England and Wales
(Jurisdiction of incorporation or organization
of issuer)
________________________________
CITIBANK, N.A.
(Exact name of depositary as specified in its charter)
____________
388 Greenwich Street
New York, New York 10013
(877) 248-4237
(Address, including zip code, and telephone number,
including area code, of depositary’s principal executive offices)
____________
Aaron Berg
President and Chief Executive Officer
Amarin Corporation plc
440 Route 22, Suite 300
Bridgewater, NJ 08807
Phone: (908) 719-1315
(Address, including zip code, and telephone number,
including area code, of agent for service)
________________________________
Copies to:
Jared Fertman, Esq.
Amanda M. Burke, Esq.
Willkie Farr & Gallagher LLP
787 Seventh Avenue
New York, New York 10019
Phone: (212) 728-8000 |
Herman H. Raspé, Esq.
Jean Claude Lanza, Esq.
Patterson Belknap Webb & Tyler LLP
1133 Avenue of the Americas
New York, New York 10036
(212) 336-2301 |
________________________________
It is proposed that this filing become effective under Rule
466 (check appropriate box): |
☐ immediately upon filing |
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☐ on (Date) at (Time). |
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If a separate registration statement has been filed to register the deposited shares, check the following box. ☐ |
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The Registrant hereby amends this Post-Effective Amendment
No. 1 to Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file
a further amendment which specifically states that this Post-Effective Amendment No. 1 to Registration Statement shall thereafter become
effective in accordance with Section 8(a) of the Securities Act of 1933, or until this Post-Effective Amendment No. 1 to Registration
Statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a), may determine. |
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This Post-Effective Amendment No. 1 to Registration
Statement on Form F-6 may be executed in any number of counterparts, each of which shall be deemed an original, and all of such counterparts
together shall constitute one and the same instrument.
PART I
INFORMATION REQUIRED IN PROSPECTUS
Cross Reference Sheet
Item 1. | DESCRIPTION
OF SECURITIES TO BE REGISTERED |
Item Number and Caption
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Location in Form of American
Depositary Receipt (“Receipt”)
Filed Herewith as Prospectus
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1. |
Name of Depositary and address of its principal executive office |
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Face of Receipt - Introductory Article. |
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2. |
Title of Receipts and identity of deposited securities |
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Face of Receipt - Top Center. |
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Terms of Deposit: |
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(i) |
The amount of deposited securities represented by one American Depositary Share (“ADSs”) |
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Face of Receipt - Upper right corner. |
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(ii) |
The procedure for voting, if any, the deposited securities |
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Reverse of Receipt - Paragraphs (16)
and (17). |
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(iii) |
The collection and distribution of dividends |
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Reverse of Receipt - Paragraph (14). |
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(iv) |
The transmission of notices, reports and proxy soliciting material |
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Face of Receipt - Paragraph (13);
Reverse of Receipt - Paragraphs (17). |
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(v) |
The sale or exercise of rights |
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Reverse of Receipt – Paragraphs (14)
and (16). |
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(vi) |
The deposit or sale of securities resulting from dividends, splits or plans of reorganization |
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Face of Receipt – Paragraphs (3) and (6);
Reverse of Receipt - Paragraphs (14) and (18). |
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(vii) |
Amendment, extension or termination of the deposit agreement |
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Reverse of Receipt - Paragraphs (22) and (23) (no provision
for extensions).
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(viii) |
Rights of holders of Receipts to inspect the transfer books of the Depositary and the list of holders of ADSs |
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Face of Receipt - Paragraph (13). |
Item Number and Caption |
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Location in Form of American
Depositary Receipt (“Receipt”)
Filed Herewith as Prospectus |
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(ix) |
Restrictions upon the right to transfer or withdraw the underlying securities |
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Face of Receipt – Paragraphs (2), (3), (4), (6), (7),
(9) and (10).
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(x) |
Limitation upon the liability of the Depositary |
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Face of Receipt - Paragraph (7);
Reverse of Receipt - Paragraphs (19) and (20). |
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3. |
Fees
and charges which may be imposed directly or indirectly on holders of ADSs
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Face of Receipt - Paragraph (10). |
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Item 2. |
AVAILABLE INFORMATION |
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Face of Receipt - Paragraph (13). |
The Company is subject to
the periodic reporting requirements of the United States Securities Exchange Act of 1934, as amended, and, accordingly, files certain
reports with, and submits certain reports to, the United States Securities and Exchange Commission (the “Commission”).
These reports can be retrieved from the Commission’s internet website (www.sec.gov), and can be inspected and copied at the public
reference facilities maintained by the Commission at 100 F Street, N.E., Washington D.C. 20549.
PROSPECTUS
The Prospectus consists of
the proposed form of American Depositary Receipt included as Exhibit A to Amendment No. 1 to Amended and Restated Deposit Agreement
filed as Exhibit (a)(i) to this Post-Effective Amendment No. 1 to Registration Statement on Form F-6 and is incorporated herein by reference.
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
| (a) | (i) Form of Amendment No. 1 to the Amended and Restated Deposit Agreement, by and among Amarin Corporation
plc (the “Company”), Citibank, N.A., as depositary (the “Depositary”), and all Holders and Beneficial
Owners of American Depositary Shares issued thereunder. ___ Filed herewith as Exhibit (a)(i). |
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| | (ii) Amended and Restated
Deposit Agreement, dated as of November 4, 2011, by and among the Company, the Depositary, and the Holders and Beneficial Owners of American
Depositary Shares issued thereunder (“Deposit Agreement”). ___ Previously filed as Exhibit (a) to the Registration
Statement on Form F-6, Reg No. 333-228591, filed on November 29, 2018, and incorporated herein by reference. |
| (b) | Any other agreement to which the Depositary is a party relating to the issuance of the American Depositary
Shares registered hereunder or the custody of the deposited securities represented thereby. ___ None. |
| (c) | Every material contract relating to the deposited securities between the Depositary and the issuer of
the deposited securities in effect at any time within the last three years. ___ None. |
| (d) | Opinion of counsel for the Depositary as to the legality of the securities to be registered. ___
Previously filed. |
| (e) | Certificate under Rule 466. ___ None. |
| (f) | Powers of Attorney for certain officers and directors and the authorized representative of the Company.
___ Set forth on the signature pages hereto. |
| (a) | The Depositary undertakes to make available at the principal office of the Depositary in the United States,
for inspection by holders of ADSs, any reports and communications received from the issuer of the deposited securities which are both
(1) received by the Depositary as the holder of the deposited securities, and (2) made generally available to the holders of the underlying
securities by the issuer. |
| (b) | If the amount of fees charged is not disclosed in the prospectus, the Depositary undertakes to prepare
a separate document stating the amount of any fee charged and describing the service for which it is charged and to deliver promptly a
copy of such fee schedule without charge to anyone upon request. The Depositary undertakes to notify each registered holder of an ADS
thirty (30) days before any change in the fee schedule. |
SIGNATURES
Pursuant to the
requirements of the Securities Act of 1933, as amended, Citibank, N.A., acting solely on behalf of the legal entity created by the
Amended and Restated Deposit Agreement, by and among Amarin Corporation plc, Citibank, N.A., as
depositary, and all Holders and Beneficial Owners from time to time of American Depositary Shares to be issued thereunder, as
amended and supplemented from time to time, certifies that it has reasonable grounds to believe that all the requirements for filing
on Form F-6 are met and has duly caused this Post-Effective Amendment No. 1 to Registration Statement on Form F-6 to be signed on
its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of New York, on the 12th day of March
2025.
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Legal entity created by the Amended and Restated Deposit Agreement under which the American Depositary Shares registered hereunder are to be issued, each American Depositary Share representing the right to receive twenty (20) ordinary shares of Amarin Corporation plc. |
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CITIBANK, N.A., solely in its capacity as Depositary |
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By: |
/s/ Leslie DeLuca |
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Name: Leslie DeLuca |
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Title: Attorney-in-Fact |
SIGNATURES
Pursuant to the requirements
of the Securities Act of 1933, as amended, Amarin Corporation plc certifies that it has reasonable grounds to believe that all the requirements
for filing on Form F-6 are met and has duly caused this Post-Effective Amendment No. 1 to Registration Statement on Form F-6 to be signed
on its behalf by the undersigned thereunto duly authorized, in Bridgewater, New Jersey on March 12, 2025.
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AMARIN CORPORATION PLC |
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By: |
/s/ Aaron Berg |
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Name: Aaron Berg |
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Title: President and Chief Executive Officer |
POWERS OF ATTORNEY
KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and appoints each of Aaron Berg and Jonathan Provoost to act
as his/her true and lawful attorney-in-fact and agent, with full power of substitution, for him/her and in his/her name, place and stead,
in any and all such capacities, to sign any and all amendments, including post-effective amendments, and supplements to this Registration
Statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the United States Securities
and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and
thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as s/he might or could do in
person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his/her substitute or substitutes, may lawfully do
or cause to be done by virtue hereof.
Pursuant to the requirements
of the Securities Act of 1933, as amended, this Post-Effective Amendment No. 1 to Registration Statement on Form F-6 has been signed by
the following persons in the following capacities on March 12, 2025.
Signature |
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Title |
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/s/ Aaron Berg |
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President, Chief Executive Officer and Director |
Aaron Berg |
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(Principal Executive Officer) |
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/s/ Peter Fishman |
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Senior Vice President and Chief Financial Officer |
Peter Fishman |
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(Principal Financial Officer, Principal Accounting Officer) |
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/s/ Odysseas Kostas M.D. |
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Director |
Odysseas Kostas M.D. |
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/s/ Patrice Bonfiglio |
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Director |
Patrice Bonfiglio |
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/s/ Paul Cohen, M.D. |
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Director |
Paul Cohen, M.D. |
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Signature |
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Title |
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/s/ Mark DiPaolo |
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Director |
Mark DiPaolo |
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/s/ Keith L. Horn |
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Director |
Keith L. Horn |
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/s/ Oliver O'Connor |
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Director |
Oliver O'Connor |
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/s/ Louis Sterling III |
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Director |
Louis Sterling III |
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/s/ Diane Sullivan |
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Director |
Diane Sullivan |
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SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE
UNITED STATES
Pursuant to the requirements
of the Securities Act of 1933, as amended, the undersigned the duly authorized representative in the United States of Amarin Corporation
plc has signed this Post-Effective Amendment No. 1 to Registration Statement on Form F-6 in Bridgewater, New Jersey, on March 12, 2025.
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Authorized U.S. Representative |
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Amarin Corporation plc |
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By: |
/s/ Aaron Berg |
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Name: Aaron Berg |
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Title: President and Chief Executive Officer |
Index to Exhibits
Exhibit |
Document |
Sequentially
Numbered Page
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(a)(i) |
Form of Amendment No. 1 to Deposit Agreement |
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Exhibit (a)(i)
AMARIN
CORPORATION PLC
and
CITIBANK, N.A.,
as Depositary,
and
THE HOLDERS
AND BENEFICIAL OWNERS OF
AMERICAN
DEPOSITARY SHARES
OUTSTANDING
UNDER THE TERMS OF THE
AMENDED AND RESTATED DEPOSIT AGREEMENT, DATED AS OF NOVEMBER 4, 2011
_____________________________________________
Amendment No. 1
to
the Amended and Restated Deposit Agreement
_____________________________________________
Dated as of [●], 2025
Table of Contents
Page
ARTICLE I |
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DEFINITIONS |
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2 |
Section 1.1 |
Definitions. |
2 |
Section 1.2 |
Effective Date |
2 |
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ARTICLE II |
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AMENDMENTS TO DEPOSIT AGREEMENT |
2 |
Section 2.1 |
Deposit Agreement |
2 |
Section 2.2 |
Amendments Binding on all Holders and Beneficial Owners |
2 |
Section 2.3 |
ADS-to-Share Ratio Change |
2 |
Section 2.4 |
Elimination of Pre-Release Transactions |
4 |
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ARTICLE III |
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AMENDMENTS TO THE FORM OF ADR |
6 |
Section 3.1 |
ADR Amendments |
6 |
Section 3.2 |
Change of Ratio |
7 |
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ARTICLE IV |
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REPRESENTATIONS AND WARRANTIES |
7 |
Section 4.1 |
Representations and Warranties |
8 |
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ARTICLE V |
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MISCELLANEOUS |
8 |
Section 5.1 |
New ADRs |
8 |
Section 5.2 |
Notice of Amendment to Holders of ADSs |
9 |
Section 5.3 |
Indemnification |
9 |
Section 5.4 |
Ratification |
9 |
Section 5.5 |
Governing Law |
9 |
Section 5.6 |
Counterparts |
9 |
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EXHIBIT A – FORM OF ADR |
A-1 |
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EXHIBIT B – NOTICE TO HOLDERS |
B-1 |
AMENDMENT NO.
1 TO THE DEPOSIT AGREEMENT
AMENDMENT NO. 1 TO THE AMENDED
AND RESTATED DEPOSIT AGREEMENT, dated as of [●], 2025 (“Amendment No. 1”), by and among Amarin Corporation plc,
a company organized under the laws of England and Wales, and its successors (the “Company”), Citibank, N.A., a national
banking association organized under the laws of the United States of America (the “Depositary”), and all Holders and
Beneficial Owners of American Depositary Shares issued and outstanding under the Deposit Agreement (as hereinafter defined).
WITNESSETH THAT:
WHEREAS, the Company
and the Depositary entered into that certain Amended and Restated Deposit Agreement, dated as of November 4, 2011 (as so amended and supplemented
from time to time prior to the date hereof, the “Deposit Agreement”), for the creation of ADSs (as defined in the Deposit
Agreement) representing the Shares (as defined in the Deposit Agreement) deposited thereunder and for the execution and delivery of American
Depositary Receipts (“ADRs”) in respect of the ADSs; and
WHEREAS, the Company
desires to (a) change the ADS-to-Share ratio from (i) the existing ratio of one (1) ADS to one (1) of one Share to (ii) a new ratio of
one (1) ADS to twenty (20) Shares, (b) eliminate the Depositary’s ability to conduct Pre-Release Transactions (as defined in the
Deposit Agreement), (c) amend the Deposit Agreement, the ADRs currently outstanding, and the form of ADR annexed as Exhibit A to
the Deposit Agreement, in each case pursuant to Section 6.1 of the Deposit Agreement, to reflect such changes, and (d) give notice thereof
to all Holders (as defined in the Deposit Agreement) of ADSs.
NOW, THEREFORE, for good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and the Depositary hereby agree
to amend the Deposit Agreement, the ADRs currently outstanding, and the form of ADR annexed as Exhibit A to the Deposit Agreement
as follows:
ARTICLE I
DEFINITIONS
Section 1.1 Definitions.
Unless otherwise specified in this Amendment No. 1, all capitalized terms used, but not defined, herein shall have the meanings ascribed
to such terms in the Deposit Agreement.
Section 1.2 Effective
Date. The term “Effective Date” shall mean the date set forth above and as of which this Amendment No. 1 shall
become effective.
ARTICLE II
AMENDMENTS TO DEPOSIT
AGREEMENT
Section 2.1 Deposit
Agreement. All references in the Deposit Agreement to the term “Deposit Agreement” shall, as of the Effective Date,
refer to the Amended and Restated Deposit Agreement, dated as of November 4, 2011, as amended by this Amendment No. 1, and as further
amended and supplemented after the Effective Date.
Section 2.2 Amendments
Binding on all Holders and Beneficial Owners. From and after the Effective Date, the Deposit Agreement, as amended by this Amendment
No. 1, the ADRs currently outstanding, and the form of ADR annexed as Exhibit A to the Deposit Agreement effected hereby shall
be binding on all Holders and Beneficial Owners of ADSs issued and outstanding as of the Effective Date and on all Holders and Beneficial
Owners of ADSs issued after the Effective Date.
Section 2.3 ADS-to-Share
Ratio Change.
(a) Section 1.4 of the Deposit Agreement is hereby amended by deleting such section as of the Effective Date and replacing such section
with the following in its stead:
“Section 1.4
“American Depositary Share(s)” and “ADS(s)” shall mean the rights and interests in the Deposited Securities
(as hereinafter defined) granted to the Holders and Beneficial Owners pursuant to the terms and conditions of the Deposit Agreement and,
if issued as Certificated ADS(s), (as hereinafter defined) the ADR(s) issued to evidence such ADSs. ADS(s) may be issued under the terms
of the Deposit Agreement in the form of (a) Certificated ADS(s) (as hereinafter defined), in which case the ADS(s) are evidenced
by ADR(s), or (b) Uncertificated ADS(s) (as hereinafter defined), in which case the ADS(s) are not evidenced by ADR(s) but are reflected
on the direct registration system maintained by the Depositary for such purposes under the terms of Section 2.13. Unless otherwise specified
in the Deposit Agreement or in any ADR, or unless the context otherwise requires, any reference to ADS(s) shall include Certificated ADS(s)
and Uncertificated ADS(s), individually or collectively, as the context may require. Each ADS shall represent the right to receive, and
to exercise the beneficial ownership interests in, the number of Shares specified in the form of ADR attached hereto as Exhibit A
(as amended from time to time) that are on deposit with the Depositary and/or the Custodian, subject, in each case, to the terms and conditions
of the Deposit Agreement and the applicable ADR (if issued as a Certificated ADS) until there shall occur a distribution upon Deposited
Securities referred to in Section 4.2 or a change in Deposited Securities referred to in Section 4.11 with respect to which additional
ADSs are not issued, and thereafter each ADS shall represent the right to receive, and to exercise the beneficial ownership interests
in, the applicable Deposited Securities on deposit with the Depositary and the Custodian determined in accordance with the terms of such
Sections, subject, in each case, to the terms and conditions of the Deposit Agreement and the applicable ADR (if issued as a Certificated
ADS). In addition, the ADS(s)-to-Share(s) ratio is subject to amendment as provided in Articles IV and VI of the Deposit Agreement. American
depositary shares outstanding under the Original Deposit Agreement as of the date hereof shall, from and after the date hereof, for all
purposes be treated as American Depositary Shares issued and outstanding hereunder and shall, from and after the date hereof, be subject
to the terms and conditions of the Deposit Agreement in all respects, except that any amendment of the Original Deposit Agreement effected
under the terms of the Deposit Agreement which shall impose or increase any fees or charges (other than the fees of the Depositary for
the execution and delivery or the cancellation of ADRs and taxes or other governmental charges), or which shall otherwise prejudice any
substantial existing right of Holders (as defined in the Original Deposit Agreement), shall not become effective as to Holders of American
depositary shares until the expiration of three months after notice of the amendments effected by the Deposit Agreement shall have been
given to the Holders of American depositary shares outstanding under the Original Deposit Agreement as of the date hereof.”
Section 2.4 Elimination
of Pre-Release Transactions.
(a) Section 1.5 of the Deposit Agreement is hereby amended by deleting such section as of the Effective Date and replacing such section
with the following in its stead:
“Section 1.5 Reserved.”
(b) Section 1.15 of the Deposit Agreement is hereby amended by deleting the last sentence of such section as of the Effective Date.
(c) Section 1.25 of the Deposit Agreement is hereby amended by deleting such section as of the Effective Date and replacing such section
with the following in its stead:
“Section 1.25 Reserved.”
(d) Section 2.5 of the Deposit Agreement is hereby amended by deleting the last sentence of such section as of the Effective Date.
(e) Section 2.14 of the Deposit Agreement is hereby amended by deleting such section as of the Effective Date and replacing such section
with the following in its stead:
“Section 2.14 Restricted ADSs.
The Depositary shall, at the request and expense of the Company, establish procedures enabling the deposit hereunder of Shares that are
Restricted Securities in order to enable the holder of such Shares to hold its ownership interests in such Restricted Shares in the form
of ADSs issued under the terms hereof (such Shares, “Restricted Shares”). Upon receipt of a written request from the
Company to accept Restricted Shares for deposit hereunder, the Depositary agrees to establish procedures permitting the deposit of such
Restricted Shares and the issuance of ADSs representing the right to receive, subject to the terms of the Deposit Agreement and the applicable
ADR (if issued as a Certificated ADS), such deposited Restricted Shares (such ADSs, the “Restricted ADSs,” and the
ADRs evidencing such Restricted ADSs, the “Restricted ADRs”). Notwithstanding anything contained in this Section 2.14,
the Depositary and the Company may, to the extent not prohibited by law, agree to issue the Restricted ADSs in uncertificated form (“Uncertificated
Restricted ADSs”) upon such terms and conditions as the Company and the Depositary may deem necessary and appropriate.
The Company shall assist the Depositary
in the establishment of such procedures and agrees that it shall take all steps necessary and satisfactory to the Depositary to ensure
that the establishment of such procedures does not violate the provisions of the Securities Act or any other applicable laws. The depositors
of such Restricted Shares and the Holders of the Restricted ADSs may be required prior to the deposit of such Restricted Shares, the
transfer of the Restricted ADRs and Restricted ADSs or the withdrawal of the Restricted Shares represented by Restricted ADSs to provide
such written certifications or agreements as the Depositary or the Company may require. The Company shall provide to the Depositary in
writing the legend(s) to be affixed to the Restricted ADRs (if the Restricted ADSs are to be issued as Certificated ADSs), or to be included
in the statements issued from time to time to Holders of Uncertificated ADSs (if issued as Uncertificated Restricted ADSs), which legends
shall (i) be in a form reasonably satisfactory to the Depositary and (ii) contain the specific circumstances under which the Restricted
ADSs, and, if applicable, the Restricted ADRs evidencing the Restricted ADSs, may be transferred or the Restricted Shares withdrawn.
The Restricted ADSs issued upon the deposit of Restricted Shares shall be separately identified on the books of the Depositary and the
Restricted Shares so deposited shall, to the extent required by law, be held separate and distinct from the other Deposited Securities
held hereunder. The Restricted ADSs shall not be eligible for inclusion in any book-entry settlement system, including, without limitation,
DTC, and shall not in any way be fungible with the ADSs issued under the terms hereof that are not Restricted ADSs. The Restricted ADSs,
and, if applicable, the Restricted ADRs evidencing the Restricted ADSs, shall be transferable only by the Holder thereof upon delivery
to the Depositary of (i) all documentation otherwise contemplated by the Deposit Agreement and (ii) an opinion of counsel satisfactory
to the Depositary setting forth, inter alia, the conditions upon which the Restricted ADSs presented, and, if applicable, the
Restricted ADRs evidencing the Restricted ADSs, are transferable by the Holder thereof under applicable securities laws and the transfer
restrictions contained in the legend applicable to the Restricted ADSs presented for transfer. Except as set forth in this Section 2.14
and except as required by applicable law, the Restricted ADSs and the Restricted ADRs evidencing Restricted ADSs shall be treated as
ADSs and ADRs issued and outstanding under the terms of the Deposit Agreement. In the event that, in determining the rights and obligations
of parties hereto with respect to any Restricted ADSs, any conflict arises between (a) the terms of the Deposit Agreement (other than
this Section 2.14) and (b) the terms of (i) this Section 2.14 or (ii) the applicable Restricted ADR, the terms and conditions set forth
in this Section 2.14 and of the Restricted ADR shall be controlling and shall govern the rights and obligations of the parties to the
Deposit Agreement pertaining to the deposited Restricted Shares, the Restricted ADSs and Restricted ADRs.
If the Restricted ADRs, the Restricted
ADSs and the Restricted Shares cease to be Restricted Securities, the Depositary, upon receipt of (x) an opinion of counsel satisfactory
to the Depositary setting forth, inter alia, that the Restricted ADRs, the Restricted ADSs and the Restricted Shares are not as
of such time Restricted Securities, and (y) instructions from the Company to remove the restrictions applicable to the Restricted ADRs,
the Restricted ADSs and the Restricted Shares, shall (i) eliminate the distinctions and separations that may have been established
between the applicable Restricted Shares held on deposit under this Section 2.14 and the other Shares held on deposit under the terms
of the Deposit Agreement that are not Restricted Shares, (ii) treat the newly unrestricted ADRs and ADSs on the same terms as, and
fully fungible with, the other ADRs and ADSs issued and outstanding under the terms of the Deposit Agreement that are not Restricted ADRs
or Restricted ADSs, (iii) take all actions necessary to remove any distinctions, limitations and restrictions previously existing
under this Section 2.14 between the applicable Restricted ADRs and Restricted ADSs, respectively, on the one hand, and the other ADRs
and ADSs that are not Restricted ADRs or Restricted ADSs, respectively, on the other hand, including, without limitation, by making the
newly-unrestricted ADSs eligible for inclusion in the applicable book-entry settlement systems.”
(f) Section 5.10 of the Deposit Agreement is hereby amended by deleting such section as of the Effective Date and replacing such section
with the following in its stead:
“Section 5.10 Certain Rights of the Depositary.
The Depositary, its Affiliates and their agents, on their own behalf, may own and deal in any class of securities of the Company and its
Affiliates and in ADSs.”
ARTICLE III
AMENDMENTS TO
THE FORM OF ADR
Section 3.1 ADR
Amendments.
(a) The phrase in the top, right-hand corner of the Form of ADR attached as Exhibit A to the Deposit Agreement and in each of
the ADRs issued and outstanding under the terms of the Deposit Agreement is hereby amended as of the Effective Date by deleting such phrase
in its entirety and inserting the following in its stead:
“American Depositary Shares (each American
Depositary Share representing the right to receive twenty (20) fully paid ordinary shares)”
(b) The second sentence of the introductory paragraph of the Form of ADR attached as Exhibit A to the Deposit Agreement and
in each of the ADRs issued and outstanding under the terms of the Deposit Agreement is hereby amended as of the Effective Date by deleting
such sentence in its entirety and inserting the following in its stead:
“As of the date of issuance of this ADR,
each ADS represents the right to receive twenty (20) Shares deposited under the Deposit Agreement (as hereinafter defined) with the Custodian,
which at the date of issuance of this ADR is Citibank, N.A. London Branch (the “Custodian”).”
(c) The first sentence of paragraph (1) of the form of ADR attached as Exhibit A to the Deposit Agreement and in each of the
ADRs issued and outstanding under the terms of the Deposit Agreement is hereby amended as of the Effective Date by deleting such sentence
in its entirety and inserting the following in its stead:
“This American Depositary Receipt is one
of an issue of American Depositary Receipts (“ADRs”), all issued and to be issued upon the terms and conditions set
forth in the Amended and Restated Deposit Agreement, dated as of November 4, 2011, as amended by Amendment No. 1 to the Deposit Agreement,
dated as of [●], 2025 (as so amended and as further amended and supplemented from time to time, the “Deposit Agreement”),
by and among the Company, the Depositary, and all Holders and Beneficial Owners from time to time of ADSs issued thereunder.”
(d) Paragraph (25) of the form of ADR attached as Exhibit A to the Deposit Agreement and in each of the ADRs issued and outstanding
under the terms of the Deposit Agreement is hereby amended as of the Effective Date by deleting such paragraph in its entirety and inserting
the following in its stead:
“(25) Certain Rights of the Depositary.
The Depositary, its Affiliates and their agents, on their own behalf, may own and deal in any class of securities of the Company and its
Affiliates and in ADSs.”
Section 3.2 Change
of Ratio. All other references to the ADS-to-Share ratio made in the form of ADR attached as Exhibit A to the Deposit Agreement
and in each of the ADRs outstanding, as of the Effective Date, under the terms of the Deposit Agreement shall, as of the Effective Date,
refer to the ADS-to-Share ratio of “one (1) ADS to twenty (20) Shares.”
ARTICLE IV
REPRESENTATIONS AND WARRANTIES
Section 4.1 Representations
and Warranties. The Company represents and warrants to, and agrees with, the Depositary and the Holders and Beneficial Owners, that:
(a) This Amendment No. 1, when executed and delivered by the Company, and the Deposit Agreement and all other documentation executed
and delivered by the Company in connection therewith, will be and have been, respectively, duly and validly authorized, executed, and
delivered by the Company, and constitute the legal, valid, and binding obligations of the Company, enforceable against the Company in
accordance with their respective terms, subject to bankruptcy, insolvency, fraudulent transfer, moratorium, and similar laws of general
applicability relating to or affecting creditors’ rights and to general equity principles; and
(b) In order to ensure the legality, validity, enforceability, or admissibility into evidence of this Amendment No. 1 or the Deposit
Agreement as amended hereby, or any other document furnished hereunder or thereunder, none of such agreements need to be filed or recorded
with any court or other authority in England and Wales, nor does any stamp or similar tax need be paid in the England and Wales on or
in respect of such agreements; and
(c) All of the information provided to the Depositary by the Company in connection with this Amendment No. 1 is true, accurate, and
correct.
ARTICLE V
MISCELLANEOUS
Section 5.1 New
ADRs. From and after the Effective Date, the Depositary shall arrange to have new ADRs printed to reflect the changes to the form
of ADR effected by this Amendment No. 1. All ADRs issued hereunder after the Effective Date, whether upon the deposit of Shares or other
Deposited Securities or upon the transfer, combination, or split up of existing ADRs, shall be substantially in the form of the specimen
ADR attached as Exhibit A hereto. ADRs issued prior or subsequent to the date hereof, which do not reflect the changes to the form
of ADR effected hereby, must be returned to the Depositary for exchange. The Depositary is authorized and directed to take any and all
actions deemed necessary to effect the foregoing.
Section 5.2 Notice
of Amendment to Holders of ADSs. The Depositary is hereby directed to send a notice informing the Holders of ADSs, inter alia,
(i) of the terms of this Amendment No. 1, (ii) of the Effective Date of this Amendment No. 1, (iii) that the Holders of ADRs, if any,
must surrender their ADRs in exchange for new ADRs reflecting the changes effected by this Amendment No. 1, as provided in Section 5.1
hereof, and (iv) that copies of this Amendment No. 1 may be retrieved from the Commission’s website at https://www.sec.gov and may
be obtained from the Depositary and the Company upon request. The notice to Holders of ADSs shall be substantially in the form of Exhibit
B attached hereto.
Section 5.3 Indemnification.
The Company agrees to indemnify and hold harmless the Depositary, the Custodian (as defined in the Deposit Agreement) (and any and all
of their directors, employees, and officers) for any and all liability it or they may incur as a result of the terms of this Amendment
No. 1 and the transactions contemplated herein.
Section 5.4 Ratification.
Except as expressly amended hereby, the terms, covenants, and conditions of the Deposit Agreement as originally executed shall remain
in full force and effect.
Section 5.5 Governing
Law. This Amendment No. 1 shall be governed by and construed in accordance with the laws of the State of New York.
Section 5.6 Counterparts.
This Amendment No. 1 may be executed in any number of counterparts, each of which shall be deemed an original, and all of such counterparts
together shall be deemed an original, and all such counterparts together shall constitute one and the same agreement.
[Signature page on following page]
IN WITNESS WHEREOF,
the Company and the Depositary have caused this Amendment No. 1 to be executed by representatives thereunto duly authorized as of the
date set forth above.
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AMARIN CORPORATION PLC |
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CITIBANK, N.A., as Depositary |
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[Signature Page to Amendment No. 1 to Deposit Agreement]
EXHIBIT A
[FORM OF ADR]
Number _____________ |
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CUSIP NUMBER: |
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American Depositary Shares (each American
Depositary Share representing the right to receive twenty (20) fully paid ordinary shares) |
AMERICAN DEPOSITARY RECEIPT
FOR
AMERICAN DEPOSITARY SHARES
representing
DEPOSITED ORDINARY SHARES
of
AMARIN CORPORATION PLC
(Incorporated under the laws of England and Wales)
CITIBANK, N.A., a national
banking association organized and existing under the laws of the United States of America, as depositary (the “Depositary”),
hereby certifies that _____________is the owner of ______________ American Depositary Shares (hereinafter “ADS”) representing
deposited ordinary shares, including evidence of rights to receive such ordinary shares (the “Shares”), of Amarin Corporation
plc, a corporation incorporated under the laws of England (the “Company”). As of the date of the Deposit Agreement
(as hereinafter defined), each ADS represents the right to receive twenty (20) Shares deposited under the Deposit Agreement with the Custodian,
which at the issuance of this ADR is Citibank, N.A. London Branch, (the “Custodian”). The ADS(s)-to-Share(s) ratio
is subject to amendment as provided in Articles IV and VI of the Deposit Agreement. The Depositary’s Principal Office is located
at 388 Greenwich Street, New York, New York 10013, U.S.A.
(1) The Deposit Agreement. This American Depositary Receipt is one of an issue of American Depositary Receipts (“ADRs”),
all issued and to be issued upon the terms and conditions set forth in the Amended and Restated Deposit Agreement, dated as of November
4, 2011, as amended by Amendment No. 1 to the Deposit Agreement, dated as of [●], 2025 (as amended and supplemented from time to
time, the “Deposit Agreement”), by and among the Company, the Depositary, and all Holders and Beneficial Owners from
time to time of ADSs issued thereunder. The Deposit Agreement sets forth the rights and obligations of Holders and Beneficial Owners of
ADSs and the rights and duties of the Depositary in respect of the Shares deposited thereunder and any and all other securities, property
and cash from time to time received in respect of such Shares and held thereunder (such Shares, securities, property and cash are herein
called “Deposited Securities”). Copies of the Deposit Agreement are on file at the Principal Office of the Depositary
and with the Custodian. Each Holder and each Beneficial Owner, upon acceptance of any ADSs (or any interest therein) issued in accordance
with the terms and conditions of the Deposit Agreement, shall be deemed for all purposes to (a) be a party to and bound by the terms of
the Deposit Agreement and applicable ADR(s), and (b) appoint the Depositary its attorney-in-fact, with full power to delegate, to act
on its behalf and to take any and all actions contemplated in the Deposit Agreement and the applicable ADR(s), to adopt any and all procedures
necessary to comply with applicable law and to take such action as the Depositary in its sole discretion may deem necessary or appropriate
to carry out the purposes of the Deposit Agreement and the applicable ADR(s), the taking of such actions to be the conclusive determinant
of the necessity and appropriateness thereof.
The statements made on the
face and reverse of this ADR are summaries of certain provisions of the Deposit Agreement and the Articles of Association of the Company
(as in effect on the date of the signing of the Deposit Agreement) and are qualified by and subject to the detailed provisions of the
Deposit Agreement and the Articles of Association, to which reference is hereby made. All capitalized terms used herein which are not
otherwise defined herein shall have the meanings ascribed thereto in the Deposit Agreement. The Depositary makes no representation or
warranty as to the validity or worth of the Deposited Securities. The Depositary has made arrangements for the acceptance of the ADSs
into DTC. Each Beneficial Owner of ADSs held through DTC must rely on the procedures of DTC and the DTC Participants to exercise and be
entitled to any rights attributable to such ADSs. The Depositary may issue Uncertificated ADSs subject, however, to the terms and conditions
of Section 2.13 of the Deposit Agreement.
(2) Withdrawal of Deposited Securities. The Holder of this ADR (and of the ADSs evidenced hereby) shall be entitled to Delivery
(at the Custodian’s designated office) of the Deposited Securities at the time represented by the ADSs evidenced hereby upon satisfaction
of each of the following conditions: (i) the Holder (or a duly authorized attorney of the Holder) has duly Delivered ADSs to the Depositary
at its Principal Office the ADSs evidenced hereby (and, if applicable, this ADR) for the purpose of withdrawal of the Deposited Securities
represented thereby, (ii) if applicable and so required by the Depositary, this ADR Delivered to the Depositary for such purpose has been
properly endorsed in blank or is accompanied by proper instruments of transfer in blank (including signature guarantees in accordance
with standard securities industry practice), (iii) if so required by the Depositary, the Holder of the ADSs has executed and delivered
to the Depositary a written order directing the Depositary to cause the Deposited Securities being withdrawn to be Delivered to or upon
the written order of the person(s) designated in such order, and (iv) all applicable fees and charges of, and expenses incurred by, the
Depositary and all applicable taxes and governmental charges (as are set forth in Section 5.9 of, and Exhibit B to, the Deposit
Agreement) have been paid, subject, however, in each case, to the terms and conditions of this ADR evidencing the surrendered ADSs,
of the Deposit Agreement, of the Company’s Articles of Association and of any applicable laws and the rules of CREST, and to any
provisions of or governing the Deposited Securities, in each case as in effect at the time thereof.
Upon satisfaction of each
of the conditions specified above, the Depositary (i) shall cancel the ADSs Delivered to it (and, if applicable, the ADRs evidencing the
ADSs so Delivered), (ii) shall direct the Registrar to record the cancellation of the ADSs so Delivered on the books maintained for
such purpose, and (iii) shall direct the Custodian to Deliver, or cause the Delivery of, in each case, without unreasonable delay,
the Deposited Securities represented by the ADSs so canceled together with any certificate or other document of title for the Deposited
Securities, or evidence of the electronic transfer thereof (if available), as the case may be, to or upon the written order of the person(s)
designated in the order delivered to the Depositary for such purpose, subject however, in each case, to the terms and conditions
of the Deposit Agreement, of this ADR evidencing the ADS so cancelled, of the Articles of Association of the Company, of any applicable
laws and of the rules of CREST, and to the terms and conditions of or governing the Deposited Securities, in each case as in effect at
the time thereof.
The Depositary shall not accept
for surrender ADSs representing less than one (1) Share. In the case of the Delivery to it of ADSs representing a number other than a
whole number of Shares, the Depositary shall cause ownership of the appropriate whole number of Shares to be Delivered in accordance with
the terms hereof, and shall, at the discretion of the Depositary, either (i) return to the person surrendering such ADSs the number
of ADSs representing any remaining fractional Share, or (ii) sell or cause to be sold the fractional Share represented by the ADSs so
surrendered and remit the proceeds of such sale (net of (a) applicable fees and charges of, and expenses incurred by, the Depositary
and (b) taxes withheld) to the person surrendering the ADSs. Notwithstanding anything else contained in this ADR or the Deposit Agreement,
the Depositary may make delivery at the Principal Office of the Depositary of (i) any cash dividends or cash distributions, or (ii) any
proceeds from the sale of any distributions of shares or rights, which are at the time held by the Depositary in respect of the Deposited
Securities represented by the ADSs surrendered for cancellation and withdrawal. At the request, risk and expense of any Holder so surrendering
ADSs represented by this ADR, and for the account of such Holder, the Depositary shall direct the Custodian to forward (to the extent
permitted by law) any cash or other property (other than securities) held by the Custodian in respect of the Deposited Securities represented
by such ADSs to the Depositary for delivery at the Principal Office of the Depositary. Such direction shall be given by letter or, at
the request, risk and expense of such Holder, by cable, telex or facsimile transmission.
(3) Transfer, Combination and Split-Up of ADRs. The Registrar shall register the transfer of this ADR (and of the ADSs represented
hereby) on the books maintained for such purpose and the Depositary shall (x) cancel this ADR and execute new ADRs evidencing the
same aggregate number of ADSs as those evidenced by this ADR canceled by the Depositary, (y) cause the Registrar to countersign such
new ADRs, and (z) Deliver such new ADRs to or upon the order of the person entitled thereto, if each of the following conditions
has been satisfied: (i) this ADR has been duly Delivered by the Holder (or by a duly authorized attorney of the Holder) to the Depositary
at its Principal Office for the purpose of effecting a transfer thereof, (ii) this surrendered ADR has been properly endorsed or
is accompanied by proper instruments of transfer (including signature guarantees in accordance with standard securities industry practice),
(iii) this surrendered ADR has been duly stamped (if required by the laws of the State of New York or of the United States), and (iv) all
applicable fees and charges of, and expenses incurred by, the Depositary and all applicable taxes and governmental charges (as are set
forth in Section 5.9 of, and Exhibit B to, the Deposit Agreement) have been paid, subject, however, in each case, to the
terms and conditions of this ADR, of the Deposit Agreement and of applicable law, in each case as in effect at the time thereof.
The Registrar shall register
the split-up or combination of this ADR (and of the ADSs represented hereby) on the books maintained for such purpose and the Depositary
shall (x) cancel this ADR and execute new ADRs for the number of ADSs requested, but in the aggregate not exceeding the number of
ADSs evidenced by this ADR canceled by the Depositary, (y) cause the Registrar to countersign such new ADRs, and (z) Deliver
such new ADRs to or upon the order of the Holder thereof, if each of the following conditions has been satisfied: (i) this ADR has
been duly Delivered by the Holder (or by a duly authorized attorney of the Holder) to the Depositary at its Principal Office for the purpose
of effecting a split-up or combination hereof, and (ii) all applicable fees and charges of, and expenses incurred by, the Depositary
and all applicable taxes and government charges (as are set forth in Section 5.9 of, and Exhibit B to, the Deposit Agreement) have
been paid, subject, however, in each case, to the terms and conditions of this ADR, of the Deposit Agreement and of applicable
law, in each case as in effect at the time thereof.
The Depositary may appoint
one or more co-transfer agents for the purpose of effecting transfers, combinations and split-ups of ADRs at designated transfer offices
on behalf of the Depositary. In carrying out its functions, a co-transfer agent may require evidence of authority and compliance with
applicable laws and other requirements by Holders or persons entitled to such ADRs and will be entitled to protection and indemnity to
the same extent as the Depositary. Such co-transfer agents may be removed and substitutes appointed by the Depositary. Each co-transfer
agent appointed under Section 2.6 of the Deposit Agreement (other than the Depositary) shall give notice in writing to the Depositary
accepting such appointment and agreeing to be bound by the applicable terms of the Deposit Agreement.
(4) Pre-Conditions to Registration, Transfer, Etc. As a condition precedent to the execution and delivery, registration
of issuance, transfer, split-up, combination or surrender, of any ADS, the delivery of any distribution thereon, or the withdrawal of
any Deposited Securities, the Depositary or the Custodian may require (i) payment from the depositor of Shares or presenter of ADSs or
of an ADR of a sum sufficient to reimburse it for any tax or other governmental charge and any stock transfer or registration fee with
respect thereto (including any such tax or charge and fee with respect to Shares being deposited or withdrawn) and payment of any applicable
fees and charges of the Depositary as provided in Section 5.9 and Exhibit B to the Deposit Agreement and in this ADR, (ii) the
production of proof satisfactory to it as to the identity and genuineness of any signature or any other matters contemplated in Section
3.1 of the Deposit Agreement, and (iii) compliance with (A) any laws or governmental regulations relating to the execution and delivery
of ADRs or ADSs or to the withdrawal of Deposited Securities and (B) such reasonable regulations as the Depositary and the Company may
establish consistent with the provisions of this ADR, if applicable, the Deposit Agreement and applicable law.
The issuance of ADSs against
deposits of Shares generally or against deposits of particular Shares may be suspended, or the deposit of particular Shares may be refused,
or the registration of transfer of ADSs in particular instances may be refused, or the registration of transfer of ADSs generally may
be suspended, during any period when the transfer books of the Company, the Depositary, a Registrar or the Share Registrar are closed
or if any such action is deemed necessary or advisable by the Depositary or the Company, in good faith, at any time or from time to time
because of any requirement of law or regulation, any government or governmental body or commission or any securities exchange on which
the Shares or ADSs are listed, or under any provision of the Deposit Agreement or this ADR, or under any provision of, or governing, the
Deposited Securities, or because of a meeting of shareholders of the Company or for any other reason, subject, in all cases to paragraph
(24) and Section 7.8 of the Deposit Agreement. Notwithstanding any provision of the Deposit Agreement or this ADR to the contrary, Holders
are entitled to surrender outstanding ADSs to withdraw the Deposited Securities associated therewith at any time subject only to (i) temporary
delays caused by closing the transfer books of the Depositary or the Company or the deposit of Shares in connection with voting at a shareholders’
meeting or the payment of dividends, (ii) the payment of fees, taxes and similar charges, (iii) compliance with any U.S. or foreign laws
or governmental regulations relating to the ADSs or the withdrawal of the Deposited Securities, and (iv) other circumstances specifically
contemplated by Instruction I.A.(l) of the General Instructions to Form F-6 (as such General Instructions may be amended from time to
time).
(5) Compliance With Information Requests. Notwithstanding any other provision of the Deposit Agreement or this ADR, each
Holder and Beneficial Owner of the ADSs represented hereby agrees to comply with requests from the Company pursuant to applicable law
and any stock exchange on which Shares or ADSs are, or will be, registered, traded or listed, or the Articles of Association of the Company,
which are made to provide information, inter alia, as to the capacity in which such Holder or Beneficial Owner owns ADSs (and Shares,
as the case may be) and regarding the identity of any other person(s) interested in such ADSs and the nature of such interest and various
other matters, whether or not they are Holders and/or Beneficial Owners at the time of such request. The Depositary agrees to use its
reasonable efforts to forward, upon the request of the Company and at the Company's expense, any such request from the Company to the
Holders and to forward to the Company any such responses to such requests received by the Depositary.
(6) Ownership Restrictions. Notwithstanding any provision of this ADR or of the Deposit Agreement, the Company may restrict
transfers of the Shares where such transfer might result in ownership of Shares exceeding limits imposed by applicable law or the Articles
of Association of the Company. The Company may also restrict, in such manner as it deems appropriate, transfers of the ADSs where such
transfer may result in the total number of Shares represented by the ADSs owned by a single Holder or Beneficial Owner to exceed any such
limits. The Company may, in its sole discretion but subject to applicable law, instruct the Depositary to take action with respect to
the ownership interest of any Holder or Beneficial Owner in excess of the limits set forth in the preceding sentence, including but not
limited to, the imposition of restrictions on the transfer of ADSs, the removal or limitation of voting rights or mandatory sale or disposition
on behalf of a Holder or Beneficial Owner of the Shares represented by the ADSs held by such Holder or Beneficial Owner in excess of such
limitations, if and to the extent such disposition is permitted by applicable law and the Articles of Association of the Company. Nothing
herein or in the Deposit Agreement shall be interpreted as obligating the Depositary or the Company to ensure compliance with the ownership
restrictions described herein or in Section 3.5 of the Deposit Agreement.
Applicable laws and regulations
may require holders and beneficial owners of Shares, including the Holders and Beneficial Owners of ADSs, to satisfy reporting requirements
and obtain regulatory approvals in certain circumstances. Holders and Beneficial Owners of ADSs are solely responsible for determining
and complying with such reporting requirements, and obtaining such approvals. Each Holder and each Beneficial Owner hereby agrees to make
such determination, file such reports, and obtain such approvals to the extent and in the form required by applicable laws and regulations
as in effect from time to time. Neither the Depositary, the Custodian, the Company or any of their respective agents or affiliates shall
be required to take any actions whatsoever on behalf of Holders or Beneficial Owners to determine or satisfy such reporting requirements
or obtain such regulatory approvals under applicable laws and regulations.
(7) Liability of Holder for Taxes and Other Charges. Any tax or other governmental charge payable by the Custodian or by
the Depositary with respect to any ADR or any Deposited Securities or ADSs shall be payable by the Holders and Beneficial Owners to the
Depositary. The Company, the Custodian and/or Depositary may withhold or deduct from any distributions made in respect of Deposited Securities,
and may sell for the account of a Holder and/or Beneficial Owner any or all of the Deposited Securities and apply such distributions and
sale proceeds in payment of, any taxes (including applicable interest and penalties) or charges that are or may be payable by Holders
or Beneficial Owners in respect of the ADSs, Deposited Securities and ADRs, the Holder and the Beneficial Owner hereof remaining liable
for any deficiency. The Custodian may refuse the deposit of Shares and the Depositary may refuse to issue ADSs, to deliver ADRs, register
the transfer of ADSs, register the split-up or combination of ADRs and (subject to paragraph (24) and Section 7.8 of the Deposit Agreement)
the withdrawal of Deposited Securities until payment in full of such tax, charge, penalty or interest is received. Every Holder and Beneficial
Owner agrees to indemnify the Depositary, the Company, the Custodian, and any of their agents, officers, employees and Affiliates for,
and hold each of them harmless from, any claims with respect to taxes (including applicable interest and penalties thereon) arising from
any tax benefit obtained for such Holder and/or Beneficial Owner.
(8) Representations and Warranties of Depositors. Each person depositing Shares under the Deposit Agreement shall be deemed
thereby to represent and warrant that (i) such Shares and the certificates therefor are duly authorized, validly issued, fully paid, non-assessable
and legally obtained by such person, (ii) all preemptive (and similar) rights, if any, with respect to such Shares have been validly
waived or exercised, (iii) the person making such deposit is duly authorized so to do, (iv) the Shares presented for deposit are
free and clear of any lien, encumbrance, security interest, charge, mortgage or adverse claim, and (v) the Shares presented for deposit
are not, and the ADSs issuable upon such deposit will not be, Restricted Securities (except as contemplated in Section 2.14 of the Deposit
Agreement), and (vi) the Shares presented for deposit have not been stripped of any rights or entitlements. Such representations
and warranties shall survive the deposit and withdrawal of Shares, the issuance and cancellation of ADSs in respect thereof and the transfer
of such ADSs. If any such representations or warranties are false in any way, the Company and the Depositary shall be authorized, at the
cost and expense of the person depositing Shares, to take any and all actions necessary to correct the consequences thereof.
(9) Proofs, Certificates and Other Information. Any person presenting Shares for deposit, and any Holder and any Beneficial
Owner may be required, and every Holder and Beneficial Owner agrees, from time to time to provide to the Depositary and the Custodian
such proof of citizenship or residence, taxpayer status, payment of all applicable taxes or other governmental charges, exchange control
approval, legal or beneficial ownership of ADSs and Deposited Securities, compliance with applicable laws, the terms of the Deposit Agreement
or the ADR(s) evidencing the ADSs and the provisions of, or governing, the Deposited Securities, to execute such certifications and to
make such representations and warranties, and to provide such other information and documentation (or, in the case of Shares in registered
form presented for deposit, such information relating to the registration on the books of the Company or of the Shares Registrar) as the
Depositary or the Custodian may deem necessary or proper or as the Company may reasonably require by written request to the Depositary
consistent with its obligations under the Deposit Agreement and the applicable ADR(s). The Depositary and the Registrar, as applicable,
may withhold the execution or delivery or registration of transfer of any ADR or ADS or the distribution or sale of any dividend or distribution
of rights or of the proceeds thereof or, to the extent not limited by paragraph (24) and Section 7.8 of the Deposit Agreement, the delivery
of any Deposited Securities until such proof or other information is filed or such certifications are executed, or such representations
and warranties are made or such other information or documentation are provided, in each case to the Depositary’s, the Registrar’s
and the Company’s satisfaction. The Depositary shall provide the Company, in a timely manner, with copies or originals if necessary
and appropriate of (i) any such proofs of citizenship or residence, taxpayer status, or exchange control approval or copies of written
representations and warranties which it receives from Holders and Beneficial Owners, and (ii) any other information or documents which
the Company may reasonably request and which the Depositary shall request and receive from any Holder or Beneficial Owner or any person
presenting Shares for deposit or ADSs for cancellation, transfer or withdrawal. Nothing herein shall obligate the Depositary to (i) obtain
any information for the Company if not provided by the Holders or Beneficial Owners, or (ii) verify or vouch for the accuracy of the information
so provided by the Holders or Beneficial Owners.
(10) Charges of Depositary. The Depositary shall charge the following fees:
| (i) | Issuance
Fee: to any person depositing Shares or to whom ADSs are issued upon the deposit of Shares
(excluding issuances as a result of distributions described in paragraph (iv) below), a fee
not in excess of U.S. $5.00 per 100 ADSs (or fraction thereof) issued under the terms of
the Deposit Agreement; |
| (ii) | Cancellation Fee: to any person surrendering ADSs for cancellation and withdrawal of Deposited
Securities or to any person to whom Deposited Securities are delivered, a fee not in excess of U.S. $5.00 per 100 ADSs (or fraction thereof)
surrendered; |
| (iii) | Cash Distribution Fee: to any Holder of ADSs, a fee not in excess of U.S. $5.00 per 100 ADSs (or
fraction thereof) held for the distribution of cash dividends or other cash distributions (i.e., sale of rights and other entitlements); |
| (iv) | Stock Distribution /Rights Exercise Fee: to any Holder of ADS(s), a fee not in excess of U.S. $5.00
per 100 ADSs (or fraction thereof) held for (a) stock dividends or other free stock distributions, or (b) exercise of rights
to purchase additional ADSs; |
| (v) | Other Distribution Fee: to any Holder of ADS(s), a fee not in excess of U.S. $5.00 per 100 ADSs
(or fraction thereof) held for the distribution of securities other than ADSs or rights to purchase additional ADSs (i.e., spin-off shares);
and |
| (vi) | Depositary Services Fee: to any Holder of ADS(s), a fee not in excess of U.S. $5.00 per 100 ADSs
(or fraction thereof) held on the applicable record date(s) established by the Depositary. |
Holders, Beneficial Owners,
persons depositing Shares and persons surrendering ADSs for cancellation and for the purpose of withdrawing Deposited Securities shall
be responsible for the following charges:
| (a) | taxes (including applicable interest and penalties) and other governmental charges; |
| (b) | such registration fees as may from time to time be in effect for the registration of Shares or other Deposited
Securities on the share register and applicable to transfers of Shares or other Deposited Securities to or from the name of the Custodian,
the Depositary or any nominees upon the making of deposits and withdrawals, respectively; |
| (c) | such cable, telex and facsimile transmission and delivery expenses as are expressly provided in the Deposit
Agreement to be at the expense of the person depositing or withdrawing Shares or Holders and Beneficial Owners of ADSs; |
| (d) | the expenses and charges incurred by the Depositary in the conversion of foreign currency; |
| (e) | such fees and expenses as are incurred by the Depositary in connection with compliance with exchange control
regulations and other regulatory requirements applicable to Shares, Deposited Securities, ADSs and ADRs; and |
| (f) | the fees and expenses incurred by the Depositary, the Custodian, or any nominee in connection with the
delivery or servicing of Deposited Securities. |
All fees and charges may,
at any time and from time to time, be changed by agreement between the Depositary and Company but, in the case of fees and charges payable
by Holders or Beneficial Owners, only in the manner contemplated by paragraph (22) of this ADR and as contemplated in the Deposit Agreement.
The Depositary will provide, without charge, a copy of its latest fee schedule to anyone upon request.
Depositary Fees payable upon
(i) deposit of Shares against issuance of ADSs and (ii) surrender of ADSs for cancellation and withdrawal of Deposited Securities
will be charged by the Depositary to the person to whom the ADSs so issued are delivered (in the case of ADS issuances) and to the person
who delivers the ADSs for cancellation to the Depositary (in the case of ADS cancellations). In the case of ADSs issued by the Depositary
into DTC or presented to the Depositary via DTC, the ADS issuance and cancellation fees will be payable to the Depositary by the DTC Participant(s)
receiving the ADSs from the Depositary or the DTC Participant(s) surrendering the ADSs to the Depositary for cancellation, as the case
may be, on behalf of the Beneficial Owner(s) and will be charged by the DTC Participant(s) to the account(s) of the applicable Beneficial
Owner(s) in accordance with the procedures and practices of the DTC participant(s) as in effect at the time. Depositary fees in respect
of distributions and the Depositary services fee are payable to the Depositary by Holders as of the applicable ADS Record Date established
by the Depositary. In the case of distributions of cash, the amount of the applicable Depositary fees is deducted by the Depositary from
the funds being distributed. In the case of distributions other than cash and the Depositary service fee, the Depositary will invoice
the applicable Holders as of the ADS Record Date established by the Depositary. For ADSs held through DTC, the Depositary fees for distributions
other than cash and the Depositary service fee are charged by the Depositary to the DTC Participants in accordance with the procedures
and practices prescribed by DTC from time to time and the DTC Participants in turn charge the amount of such fees to the Beneficial Owners
for whom they hold ADSs.
The Depositary may reimburse
the Company for certain expenses incurred by the Company in respect of the ADR program established pursuant to the Deposit Agreement,
by making available a portion of the Depositary fees charged in respect of the ADR program or otherwise, upon such terms and conditions
as the Company and the Depositary agree from time to time. The Company shall pay to the Depositary such fees and charges and reimburse
the Depositary for such out-of-pocket expenses as the Depositary and the Company may agree from time to time. Responsibility for payment
of such charges and reimbursements may from time to time be changed by agreement between the Company and the Depositary. Unless otherwise
agreed, the Depositary shall present its statement for such expenses and fees or charges to the Company once every three months. The charges
and expenses of the Custodian are for the sole account of the Depositary.
The right of the Depositary
to receive payment of fees, charges and expenses as provided above shall survive the termination of the Deposit Agreement. As to any Depositary,
upon the resignation or removal of such Depositary as described in Section 5.4 of the Deposit Agreement, such right shall extend for those
fees, charges and expenses incurred prior to the effectiveness of such resignation or removal.
(11) Title to ADRs. It is a condition of this ADR, and every successive Holder of this ADR by accepting or holding the same
consents and agrees, that title to this ADR (and to each ADS evidenced hereby) shall be transferable upon the same terms as a certificated
security under the laws of the State of New York, provided that, in the case of Certificated ADSs, such ADR has been properly endorsed
or is accompanied by proper instruments of transfer. Notwithstanding any notice to the contrary, the Depositary and the Company may deem
and treat the Holder of this ADR (that is, the person in whose name this ADR is registered on the books of the Depositary) as the absolute
owner thereof for all purposes. Neither the Depositary nor the Company shall have any obligation nor be subject to any liability under
the Deposit Agreement or this ADR to any holder of this ADR or any Beneficial Owner unless, in the case of a holder of ADSs, such holder
is the Holder of this ADR registered on the books of the Depositary or, in the case of a Beneficial Owner, such Beneficial Owner or the
Beneficial Owner’s representative is the Holder registered on the books of the Depositary.
(12) Validity of ADR. The Holder(s) of this ADR (and the ADSs represented hereby) shall not be entitled to any benefits under
the Deposit Agreement or be valid or enforceable for any purpose against the Depositary or the Company unless this ADR has been (i) dated,
(ii) signed by the manual or facsimile signature of a duly-authorized signatory of the Depositary, (iii) countersigned by the manual or
facsimile signature of a duly-authorized signatory of the Registrar, and (iv) registered in the books maintained by the Registrar for
the registration of issuances and transfers of ADRs. An ADR bearing the facsimile signature of a duly-authorized signatory of the Depositary
or the Registrar, who at the time of signature was a duly authorized signatory of the Depositary or the Registrar, as the case may be,
shall bind the Depositary, notwithstanding the fact that such signatory has ceased to be so authorized prior to the delivery of such ADR
by the Depositary.
(13) Available Information; Reports; Inspection of Transfer Books. The Company is subject to the periodic reporting requirements
of the Exchange Act and, accordingly, is required to file or submit certain reports with the Commission. These reports can be retrieved
from the Commission's website (www.sec.gov) and can be inspected and copied at the public reference facilities maintained by the Commission
located (as of the date of the Deposit Agreement) at 100 F Street, N.E., Washington D.C. 20549. The Depositary shall make available for
inspection by Holders at its Principal Office any reports and communications, including any proxy soliciting materials, received from
the Company which are both (a) received by the Depositary, the Custodian, or the nominee of either of them as the holder of the Deposited
Securities and (b) made generally available to the holders of such Deposited Securities by the Company. The Depositary shall also provide
or make available to Holders copies of such reports when furnished by the Company pursuant to Section 5.6 of the Deposit Agreement.
The Registrar shall keep books
for the registration of ADSs which at all reasonable times shall be open for inspection by the Company and by the Holders of such ADSs,
provided that such inspection shall not be, to the Registrar’s knowledge, for the purpose of communicating with Holders of such
ADSs in the interest of a business or object other than the business of the Company or other than a matter related to the Deposit Agreement
or the ADSs.
The Registrar may close the
transfer books with respect to the ADSs, at any time or from time to time, when deemed necessary or advisable by it in good faith in connection
with the performance of its duties hereunder, or at the reasonable written request of the Company subject, in all cases, to paragraph
(24) and Section 7.8 of the Deposit Agreement.
Dated:
CITIBANK, N.A.
Transfer Agent and Registrar |
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CITIBANK, N.A.
as Depositary |
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By: |
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By: |
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Authorized Signatory |
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Authorized Signatory |
The address of the Principal Office of the Depositary
is 388 Greenwich Street, New York, New York 10013, U.S.A.
FORM OF REVERSE OF ADR
SUMMARY OF CERTAIN ADDITIONAL PROVISIONS
OF THE DEPOSIT AGREEMENT
(14) Dividends and Distributions in Cash, Shares, etc. Whenever the Company intends to make a distribution of a cash dividend
or other cash distribution, the Company shall give notice thereof to the Depositary at least twenty (20) days prior to the proposed distribution,
specifying, inter alia, the record date applicable for determining the holders of Deposited Securities entitled to receive such
distribution. Upon the timely receipt of such notice, the Depositary shall establish an ADS Record Date upon the terms described in Section
4.9 of the Deposit Agreement. Upon receipt of confirmation from the Custodian of the receipt of any cash dividend or other cash distribution
on any Deposited Securities, or upon receipt of proceeds from the sale of any Deposited Securities or of any entitlements held in respect
of Deposited Securities under the terms of the Deposit Agreement, the Depositary will (i) if at the time of receipt thereof any amounts
received in a Foreign Currency can, in the judgment of the Depositary (upon the terms of Section 4.8 of the Deposit Agreement), be converted
on a practicable basis into Dollars transferable to the United States, promptly convert or cause to be converted such cash dividend, distribution
or proceeds into Dollars (upon the terms of Section 4.8 of the Deposit Agreement), (ii) if applicable and unless previously established,
establish the ADS Record Date upon the terms described in Section 4.9 of the Deposit Agreement, and (iii) distribute promptly the
amount thus received (net of (a) applicable fees and charges of, and expenses incurred by, the Depositary and (b) taxes withheld) to the
Holders entitled thereto as of the ADS Record Date in proportion to the number of ADSs held as of the ADS Record Date. The Depositary
shall distribute only such amount, however, as can be distributed without attributing to any Holder a fraction of one cent, and any balance
not so distributed shall be held by the Depositary (without liability for interest thereon) and shall be added to and become part of the
next sum received by the Depositary for distribution to Holders of ADSs outstanding at the time of the next distribution. If the Company,
the Custodian or the Depositary is required to withhold and does withhold from any cash dividend or other cash distribution in respect
of any Deposited Securities an amount on account of taxes, duties or other governmental charges, the amount distributed to Holders on
the ADSs representing such Deposited Securities shall be reduced accordingly. Such withheld amounts shall be forwarded by the Company,
the Custodian or the Depositary to the relevant governmental authority. Evidence of payment thereof by the Company shall be forwarded
by the Company to the Depositary upon request. The Depositary will hold any cash amounts it is unable to distribute in a non-interest
bearing account for the benefit of the applicable Holders and Beneficial Owners of ADSs until the distribution can be effected or the
funds that the Depositary holds must be escheated as unclaimed property in accordance with the laws of the relevant states of the United
States.
Whenever the Company intends
to make a distribution that consists of a dividend in, or free distribution of, Shares, the Company shall give notice thereof to the Depositary
at least twenty (20) days prior to the proposed distribution, specifying, inter alia, the record date applicable to holders of
Deposited Securities entitled to receive such distribution. Upon the timely receipt of such notice from the Company, the Depositary shall
establish an ADS Record Date upon the terms described in Section 4.9 of the Deposit Agreement. Upon receipt of confirmation from the Custodian
of the receipt of the Shares so distributed by the Company, the Depositary shall either (i) subject to Section 5.9 of the Deposit Agreement,
distribute to the Holders as of the ADS Record Date in proportion to the number of ADSs held as of the ADS Record Date, additional ADSs,
which represent in the aggregate the number of Shares received as such dividend, or free distribution, subject to the other terms of the
Deposit Agreement (including, without limitation, (a) the applicable fees and charges of, and expenses incurred by, the Depositary and
(b) taxes), or (ii) if additional ADSs are not so distributed, take all actions necessary so that each ADS issued and outstanding after
the ADS Record Date shall, to the extent permissible by law, thenceforth also represent rights and interest in the additional integral
number of Shares distributed upon the Deposited Securities represented thereby (net of (a) the applicable fees and charges of, and expenses
incurred by, the Depositary, and (b) taxes). In lieu of delivering fractional ADSs, the Depositary shall sell the number of Shares or
ADSs, as the case may be, represented by the aggregate of such fractions and distribute the net proceeds upon the terms set forth in Section
4.1 of the Deposit Agreement.
In the event that the Depositary
determines that any distribution in property (including Shares) is subject to any tax or other governmental charges which the Depositary
is obligated to withhold, or, if the Company in the fulfillment of its obligations under Section 5.7 of the Deposit Agreement, has furnished
an opinion of U.S. counsel determining that Shares must be registered under the Securities Act or other laws in order to be distributed
to Holders (and no such registration statement has been declared effective), the Depositary may dispose of all or a portion of such property
(including Shares and rights to subscribe therefor) in such amounts and in such manner, including by public or private sale, as the Depositary
deems necessary and practicable, and the Depositary shall distribute the net proceeds of any such sale (after deduction of (a) taxes and
(b) fees and charges of, and the expenses incurred by, the Depositary) to Holders entitled thereto upon the terms of Section 4.1
of the Deposit Agreement. The Depositary shall hold and/or distribute any unsold balance of such property in accordance with the provisions
of the Deposit Agreement.
Whenever the Company intends
to make a distribution payable at the election of the holders of Shares in cash or in additional Shares, the Company shall give timely
notice thereof to the Depositary at least sixty (60) days prior to the proposed distribution specifying, inter alia, the record date applicable
to holders of Deposited Securities entitled to receive such elective distribution and whether or not it wishes such elective distribution
to be made available to Holders of ADSs. Upon the timely receipt of a notice indicating that the Company wishes such elective distribution
to be made available to Holders of ADSs, the Depositary shall consult with the Company to determine, and the Company shall assist the
Depositary in its determination, whether it is lawful and reasonably practicable to make such elective distribution available to the Holders
of ADSs. The Depositary shall make such elective distribution available to Holders only if (i) the Company shall have timely requested
that the elective distribution be made available to Holders, (ii) the Depositary shall have determined that such distribution is reasonably
practicable and (iii) the Depositary shall have received satisfactory documentation within the terms of Section 5.7 of the Deposit Agreement.
If the above conditions are not satisfied, the Depositary shall establish an ADS Record Date on the terms described in Section 4.9 of
the Deposit Agreement and, to the extent permitted by law, distribute to the Holders, on the basis of the same determination as is made
in respect of the Shares for which no election is made, either (X) cash upon the terms described in Section 4.1 of the Deposit Agreement
or (Y) additional ADSs representing such additional Shares upon the terms described in Section 4.2 of the Deposit Agreement. If the above
conditions are satisfied, the Depositary shall establish an ADS Record Date on the terms described in Section 4.9 and establish procedures
to enable Holders to elect the receipt of the proposed distribution in cash or in additional ADSs. The Company shall assist the Depositary
in establishing such procedures to the extent necessary. If a Holder elects to receive the proposed distribution (X) in cash, the distribution
shall be made upon the terms described in Section 4.1 of the Deposit Agreement, or (Y) in ADSs, the distribution shall be made upon the
terms described in Section 4.2 of the Deposit Agreement. Nothing herein shall obligate the Depositary to make available to Holders a method
to receive the elective distribution in Shares (rather than ADSs). There can be no assurance that Holders generally, or any Holder in
particular, will be given the opportunity to receive elective distributions on the same terms and conditions as the holders of Shares.
Whenever the Company intends
to distribute to the holders of the Deposited Securities rights to subscribe for additional Shares, the Company shall give notice thereof
to the Depositary at least sixty (60) days prior to the proposed distribution specifying, inter alia, the record date applicable to holders
of Deposited Securities entitled to receive such distribution and whether or not it wishes such rights to be made available to Holders
of ADSs. Upon the timely receipt of a notice indicating that the Company wishes such rights to be made available to Holders of ADSs, the
Depositary shall consult with the Company to determine, and the Company shall assist the Depositary in its determination, whether it is
lawful and reasonably practicable to make such rights available to the Holders. The Depositary shall make such rights available to Holders
only if (i) the Company shall have timely requested that such rights be made available to Holders, (ii) the Depositary shall have received
satisfactory documentation within the terms of Section 5.7 of the Deposit Agreement, and (iii) the Depositary shall have determined that
such distribution of rights is reasonably practicable. In the event any of the conditions set forth above are not satisfied or if the
Company requests that the rights not be made available to Holders of ADSs, the Depositary shall proceed with the sale of the rights as
contemplated in Section 4.4(b) of the Deposit Agreement. In the event all conditions set forth above are satisfied, the Depositary shall
establish an ADS Record Date (upon the terms described in Section 4.9 of the Deposit Agreement) and establish procedures to (x) distribute
rights to purchase additional ADSs (by means of warrants or otherwise), (y) to enable the Holders to exercise such rights (upon payment
of the subscription price and of the applicable (a) fees and charges of, and expenses incurred by, the Depositary and (b) taxes), and
(z) to deliver ADSs upon the valid exercise of such rights. The Company shall assist the Depositary to the extent necessary in establishing
such procedures. Nothing herein shall obligate the Depositary to make available to the Holders a method to exercise rights to subscribe
for Shares (rather than ADSs).
If (i) the Company does not
timely request the Depositary to make the rights available to Holders or requests that the rights not be made available to Holders, (ii)
the Depositary fails to receive satisfactory documentation within the terms of Section 5.7 of the Deposit Agreement or determines it is
not reasonably practicable to make the rights available to Holders, or (iii) any rights made available are not exercised and appear to
be about to lapse, the Depositary shall determine whether it is lawful and reasonably practicable to sell such rights, in a riskless principal
capacity, at such place and upon such terms (including public or private sale) as it may deem practicable. The Company shall assist the
Depositary to the extent necessary to determine such legality and practicability. The Depositary shall, upon such sale, convert and distribute
proceeds of such sale (net of applicable (a) fees and charges of, and expenses incurred by, the Depositary and (b) taxes) upon the terms
set forth in Section 4.1 of the Deposit Agreement.
If the Depositary is unable
to make any rights available to Holders upon the terms described in Section 4.4(a) of the Deposit Agreement or to arrange for the sale
of the rights upon the terms described in Section 4.4(b) of the Deposit Agreement, the Depositary shall allow such rights to lapse.
The Depositary shall not be
responsible for (i) any failure to determine that it may be lawful or practicable to make such rights available to Holders in general
or any Holders in particular, (ii) any foreign exchange exposure or loss incurred in connection with such sale, or exercise, or (iii)
the content of any materials forwarded to the Holders on behalf of the Company in connection with the rights distribution.
Notwithstanding anything to
the contrary in Section 4.4 of the Deposit Agreement, if registration (under the Securities Act or any other applicable law) of the rights
or the securities to which any rights relate may be required in order for the Company to offer such rights or such securities to Holders
and to sell the securities represented by such rights, the Depositary will not distribute such rights to the Holders (i) unless and until
a registration statement under the Securities Act (or other applicable law) covering such offering is in effect or (ii) unless the Company
furnishes the Depositary opinion(s) of counsel for the Company in the United States and counsel to the Company in any other applicable
country in which rights would be distributed, in each case satisfactory to the Depositary, to the effect that the offering and sale of
such securities to Holders and Beneficial Owners are exempt from, or do not require registration under, the provisions of the Securities
Act or any other applicable laws.
In the event that the Company,
the Depositary or the Custodian shall be required to withhold and does withhold from any distribution of property (including rights) an
amount on account of taxes or other governmental charges, the amount distributed to the Holders of ADSs representing such Deposited Securities
shall be reduced accordingly. In the event that the Depositary determines that any distribution in property (including Shares and rights
to subscribe therefor) is subject to any tax or other governmental charges which the Depositary is obligated to withhold, the Depositary
may dispose of all or a portion of such property (including Shares and rights to subscribe therefor) in such amounts and in such manner,
including by public or private sale, as the Depositary deems necessary and practicable to pay any such taxes or charges.
There can be no assurance
that Holders generally, or any Holder in particular, will be given the opportunity to receive or exercise rights on the same terms and
conditions as the holders of Shares or be able to exercise such rights. Nothing herein shall obligate the Company to file any registration
statement in respect of any rights or Shares or other securities to be acquired upon the exercise of such rights.
Whenever the Company intends
to distribute to the holders of Deposited Securities property other than cash, Shares or rights to purchase additional Shares, the Company
shall give timely notice thereof to the Depositary and shall indicate whether or not it wishes such distribution to be made to Holders
of ADSs. Upon receipt of a notice indicating that the Company wishes such distribution be made to Holders of ADSs, the Depositary shall
consult with the Company, and the Company shall assist the Depositary, to determine whether such distribution to Holders is lawful and
reasonably practicable. The Depositary shall not make such distribution unless (i) the Company shall have requested the Depositary to
make such distribution to Holders, (ii) the Depositary shall have received satisfactory documentation within the terms of Section 5.7
of the Deposit Agreement, and (iii) the Depositary shall have determined that such distribution is reasonably practicable.
Upon receipt of satisfactory
documentation and the request of the Company to distribute property to Holders of ADSs and after making the requisite determinations set
forth in (a) above, the Depositary shall distribute the property so received to the Holders of record, as of the ADS Record Date, in proportion
to the number of ADSs held by them respectively and in such manner as the Depositary may deem practicable for accomplishing such distribution
(i) upon receipt of payment or net of the applicable fees and charges of, and expenses incurred by, the Depositary, and (ii) net of any
taxes withheld. The Depositary may dispose of all or a portion of the property so distributed and deposited, in such amounts and in such
manner (including public or private sale) as the Depositary may deem practicable or necessary to satisfy any taxes (including applicable
interest and penalties) or other governmental charges applicable to the distribution.
If (i) the Company does not
request the Depositary to make such distribution to Holders or requests not to make such distribution to Holders, (ii) the Depositary
does not receive satisfactory documentation within the terms of Section 5.7 of the Deposit Agreement, or (iii) the Depositary determines
that all or a portion of such distribution is not reasonably practicable, the Depositary shall sell or cause such property to be sold
in a public or private sale, at such place or places and upon such terms as it may deem practicable and shall (i) cause the proceeds of
such sale, if any, to be converted into Dollars and (ii) distribute the proceeds of such conversion received by the Depositary (net of
applicable (a) fees and charges of, and expenses incurred by, the Depositary and (b) taxes) to the Holders as of the ADS Record Date upon
the terms of Section 4.1 of the Deposit Agreement. If the Depositary is unable to sell such property, the Depositary may dispose of such
property for the account of the Holders in any way it deems reasonably practicable under the circumstances.
(15) Redemption. If the Company intends to exercise any right of redemption in respect of any of the Deposited Securities,
the Company shall give timely notice thereof to the Depositary at least sixty (60) days prior to the intended date of redemption which
notice shall set forth the particulars of the proposed redemption. Upon timely receipt of (i) such notice and (ii) satisfactory documentation
given by the Company to the Depositary within the terms of Section 5.7 of the Deposit Agreement, and only if the Depositary shall have
determined that such proposed redemption is practicable, the Depositary shall provide to each Holder a notice setting forth the intended
exercise by the Company of the redemption rights and any other particulars set forth in the Company’s notice to the Depositary.
The Depositary shall instruct the Custodian to present to the Company the Deposited Securities in respect of which redemption rights are
being exercised against payment of the applicable redemption price. Upon receipt of confirmation from the Custodian that the redemption
has taken place and that funds representing the redemption price have been received, the Depositary shall convert, transfer, distribute
the proceeds (net of applicable (a) fees and charges of, and expenses incurred by, the Depositary, and (b) taxes), retire ADSs and cancel
ADRs, if applicable, upon delivery of such ADSs by Holders thereof and upon the terms set forth in Sections 4.1 and 6.2 of the Deposit
Agreement. If less than all outstanding Deposited Securities are redeemed, the ADSs to be retired will be selected by lot or on a pro
rata basis, as may be determined by the Depositary. The redemption price per ADS shall be the dollar equivalent of the per share amount
received by the Depositary (adjusted to reflect the ADS(s)-to-Share(s) ratio) upon the redemption of the Deposited Securities represented
by ADSs (subject to the terms of Section 4.8 of the Deposit Agreement and the applicable fees and charges of, and expenses incurred by,
the Depositary, and taxes) multiplied by the number of Deposited Securities represented by each ADS redeemed.
(16) Fixing of ADS Record Date. Whenever the Depositary shall receive notice of the fixing of a record date by the Company
for the determination of holders of Deposited Securities entitled to receive any distribution (whether in cash, Shares, rights or other
distribution), or whenever for any reason the Depositary causes a change in the number of Shares that are represented by each ADS, or
whenever the Depositary shall receive notice of any meeting of, or solicitation of consents or proxies of, holders of Shares or other
Deposited Securities, or whenever the Depositary shall find it necessary or convenient in connection with the giving of any notice, solicitation
of any consent or any other matter, the Depositary shall fix a record date (“ADS Record Date”) for the determination
of the Holders of ADSs who shall be entitled to receive such distribution, to give instructions for the exercise of voting rights at any
such meeting, to give or withhold such consent, to receive such notice or solicitation or to otherwise take action, or to exercise the
rights of Holders with respect to such changed number of Shares represented by each ADS. The Depositary shall make reasonable efforts
to establish the ADS Record Date as closely as possible to the applicable record date for the Deposited Securities (if any) set by the
Company under English law and the Company's Articles of Association. Subject to applicable law and the terms and conditions of this ADR
and Sections 4.1 through 4.8 of the Deposit Agreement, only the Holders of ADSs at the close of business in New York on such ADS Record
Date shall be entitled to receive such distributions, to give such instructions, to receive such notice or solicitation, or otherwise
take action.
(17) Voting of Deposited Securities. As soon as practicable after receipt of notice of any meeting at which the holders of
Deposited Securities are entitled to vote, or of solicitation of consents or proxies from holders of Deposited Securities, the Depositary
shall fix the ADS Record Date in respect of such meeting or solicitation of such consent or proxy in accordance with Section 4.9 of the
Deposit Agreement. The Depositary shall, if requested by the Company in writing in a timely manner (the Depositary having no obligation
to take any further action if the request shall not have been received by the Depositary at least thirty (30) days prior to the date of
such vote or meeting), at the Company’s expense and provided no U.S. legal prohibitions exist, distribute to Holders as of the ADS
Record Date: (a) such notice of meeting or solicitation of consent or proxies, (b) a statement that the Holders at the close of business
on the ADS Record Date will be entitled, subject to any applicable law, the provisions of the Deposit Agreement, the Articles of Association
and the provisions of or governing Deposited Securities (which provisions, if any, shall be summarized in pertinent part by the Company),
to instruct the Depositary as to the exercise of the voting rights, if any, pertaining to the Deposited Securities represented by such
Holder’s ADSs and (c) a brief statement as to the manner in which such voting instructions may be given.
Notwithstanding anything contained
in the Deposit Agreement or any ADR, with the Company’s prior consent, the Depositary may, to the extent not prohibited by law or
regulations, or by the requirements of the stock exchange on which the ADSs are listed, in lieu of distribution of the materials provided
to the Depositary in connection with any meeting of, or solicitation of consents or proxies from, holders of Deposited Securities, distribute
to the Holders a notice that provides Holders with, or otherwise publicizes to Holders, instructions on how to retrieve such materials
or receive such materials upon request (i.e., by reference to a website containing the materials for retrieval or a contact for
requesting copies of the materials).
Voting instructions may be
given only in respect of a number of ADSs representing an integral number of Deposited Securities. Upon the timely receipt from a Holder
of ADSs as of the ADS Record Date of voting instructions in the manner specified by the Depositary, the Depositary shall endeavor, insofar
as practicable and permitted under applicable law, the provisions of the Deposit Agreement, Articles of Association of the Company and
the provisions of the Deposited Securities, to vote, or cause the Custodian to vote, the Deposited Securities (in person or by proxy)
represented by such Holder’s ADSs in accordance with such voting instructions.
Neither the Depositary nor
the Custodian shall under any circumstances exercise any discretion as to voting and neither the Depositary nor the Custodian shall vote,
attempt to exercise the right to vote, or in any way make use of the Deposited Securities represented by ADSs, except pursuant to and
in accordance with the voting instructions timely received from Holders or as otherwise contemplated herein. If the Depositary timely
receives voting instructions from a Holder which fail to specify the manner in which the Depositary is to vote the Deposited Securities
represented by such Holder’s ADSs, the Depositary will deem such Holder (unless otherwise specified in the notice distributed to
Holders) to have instructed the Depositary to vote in favor of the items set forth in such instructions. Deposited Securities represented
by ADSs for which no timely voting instructions are received by the Depositary from the Holder shall not be voted. Notwithstanding anything
else contained herein, the Depositary shall, if so requested in writing by the Company, represent all Deposited Securities (whether or
not voting instructions have been received in respect of such Deposited Securities from Holders as of the ADS Record Date) for the sole
purpose of establishing quorum at a meeting of shareholders. Notwithstanding anything else contained in the Deposit Agreement or this
ADR, the Depositary shall not have any obligation to take any action with respect to any meeting, or solicitation of consents or proxies,
of holders of Deposited Securities if the taking of such action would violate U.S. laws. The Company agrees to take any and all actions
reasonably necessary to enable Holders and Beneficial Owners to exercise the voting rights accruing to the Deposited Securities and to
deliver to the Depositary an opinion of U.S. counsel addressing any actions requested to be taken if so requested by the Depositary. There
can be no assurance that Holders generally or any Holder in particular will receive the notice described above with sufficient time to
enable the Holder to return voting instructions to the Depositary in a timely manner.
(18) Changes Affecting Deposited Securities. Upon any change in nominal or par value, split-up, cancellation, consolidation
or any other reclassification of Deposited Securities, or upon any recapitalization, reorganization, merger, consolidation or sale of
assets affecting the Company or to which it is a party, any securities which shall be received by the Depositary or the Custodian in exchange
for, or in conversion of or replacement of or otherwise in respect of, such Deposited Securities shall, to the extent permitted by law,
be treated as new Deposited Securities under the Deposit Agreement, and the ADRs shall, subject to the provisions of the Deposit Agreement
and applicable law, evidence ADSs representing the right to receive such additional or replacement securities. In giving effect to such
change, split-up, cancellation, consolidation or other reclassification of Deposited Securities, recapitalization, reorganization, merger,
consolidation or sale of assets, the Depositary may, with the Company’s approval, and shall, if the Company shall so request, subject
to the terms of the Deposit Agreement and receipt of an opinion of counsel to the Company satisfactory to the Depositary that such actions
are not in violation of any applicable laws or regulations, (i) issue and deliver additional ADSs as in the case of a stock dividend
on the Shares, (ii) amend the Deposit Agreement and the applicable ADRs, (iii) amend the applicable Registration Statement(s) on
Form F-6 as filed with the Commission in respect of the ADSs, (iv) call for the surrender of outstanding ADRs to be exchanged for
new ADRs, and (v) take such other actions as are appropriate to reflect the transaction with respect to the ADSs. The Company agrees to,
jointly with the Depositary, amend the Registration Statement on Form F-6 as filed with the Commission to permit the issuance of such
new form of ADRs. Notwithstanding the foregoing, in the event that any security so received may not be lawfully distributed to some or
all Holders, the Depositary may, with the Company’s approval, and shall, if the Company requests, subject to receipt of an opinion
of Company’s counsel satisfactory to the Depositary that such action is not in violation of any applicable laws or regulations,
sell such securities at public or private sale, at such place or places and upon such terms as it may deem proper and may allocate the
net proceeds of such sales (net of (a) fees and charges of, and expenses incurred by, the Depositary and (b) taxes) for the account of
the Holders otherwise entitled to such securities upon an averaged or other practicable basis without regard to any distinctions among
such Holders and distribute the net proceeds so allocated to the extent practicable as in the case of a distribution received in cash
pursuant to Section 4.1 of the Deposit Agreement. The Depositary shall not be responsible for (i) any failure to determine that it may
be lawful or practicable to make such securities available to Holders in general or any Holder in particular, (ii) any foreign exchange
exposure or loss incurred in connection with such sale, or (iii) any liability to the purchaser of such securities.
(19) Exoneration. Neither the Depositary nor the Company shall be obligated to do or perform any act which is inconsistent
with the provisions of the Deposit Agreement or incur any liability (i) if the Depositary or the Company shall be prevented or forbidden
from, or delayed in, doing or performing any act or thing required by the terms of the Deposit Agreement and this ADR, by reason of any
provision of any present or future law or regulation of the United States, England or any other country, or of any other governmental
authority or regulatory authority or stock exchange, or on account of the possible criminal or civil penalties or restraint, or by reason
of any provision, present or future, of the Articles of Association of the Company or any provision of or governing any Deposited Securities,
or by reason of any act of God or war or other circumstances beyond its control (including, without limitation, nationalization, expropriation,
currency restrictions, work stoppage, strikes, civil unrest, acts of terrorism, revolutions, rebellions, explosions and computer failure),
(ii) by reason of any exercise of, or failure to exercise, any discretion provided for in the Deposit Agreement or in the Articles of
Association of the Company or provisions of or governing Deposited Securities, (iii) for any action or inaction in reliance upon the advice
of or information from legal counsel, accountants, any person presenting Shares for deposit, any Holder, any Beneficial Owner or authorized
representative thereof, or any other person believed by it in good faith to be competent to give such advice or information, (iv) for
the inability by a Holder or Beneficial Owner to benefit from any distribution, offering, right or other benefit which is made available
to holders of Deposited Securities but is not, under the terms of the Deposit Agreement, made available to Holders of ADSs or (v) for
any consequential or punitive damages for any breach of the terms of the Deposit Agreement. The Depositary, its controlling persons, its
agents, any Custodian and the Company, its controlling persons and its agents may rely and shall be protected in acting upon any written
notice, request or other document believed by it to be genuine and to have been signed or presented by the proper party or parties. No
disclaimer of liability under the Securities Act is intended by any provision of the Deposit Agreement or this ADR.
(20) Standard of Care. The Company and the Depositary assume no obligation and shall not be subject to any liability under
the Deposit Agreement or this ADR to any Holder(s) or Beneficial Owner(s), except that the Company and Depositary agree to perform their
respective obligations specifically set forth in the Deposit Agreement and this ADR without negligence or bad faith. Without limitation
of the foregoing, neither the Depositary, nor the Company, nor any of their respective controlling persons, or agents, shall be under
any obligation to appear in, prosecute or defend any action, suit or other proceeding in respect of any Deposited Securities or in respect
of the ADSs, which in its opinion may involve it in expense or liability, unless indemnity satisfactory to it against all expense (including
fees and disbursements of counsel) and liability be furnished as often as may be required (and no Custodian shall be under any obligation
whatsoever with respect to such proceedings, the responsibility of the Custodian being solely to the Depositary). The Depositary and its
agents shall not be liable for any failure to carry out any instructions to vote any of the Deposited Securities, or for the manner in
which any vote is cast or the effect of any vote, provided that any such action or omission is in good faith and in accordance with the
terms of the Deposit Agreement. The Depositary shall not incur any liability for any failure to determine that any distribution or action
may be lawful or reasonably practicable, for the content of any information submitted to it by the Company for distribution to the Holders
or for any inaccuracy of any translation thereof, for any investment risk associated with acquiring an interest in the Deposited Securities,
for the validity or worth of the Deposited Securities or for any tax consequences that may result from the ownership of ADSs, Shares or
Deposited Securities, for the credit-worthiness of any third party, for allowing any rights to lapse upon the terms of the Deposit Agreement,
for the failure or timeliness of any notice from the Company, or for any action or failure to act by, or any information provided or not
provided by, DTC or any DTC participant.
The Depositary shall not be
liable for any acts or omissions made by a successor depositary whether in connection with a previous act or omission of the Depositary
or in connection with any matter arising wholly after the removal or resignation of the Depositary, provided that in connection with the
issue out of which such potential liability arises the Depositary performed its obligations without negligence or bad faith while it acted
as Depositary.
(21) Resignation and Removal of the Depositary; Appointment of Successor Depositary. The Depositary may at any time resign
as Depositary under the Deposit Agreement by written notice of resignation delivered to the Company, such resignation to be effective
on the earlier of (i) the 90th day after delivery thereof to the Company (whereupon the Depositary shall be entitled to take the actions
contemplated in Section 6.2 of the Deposit Agreement), or (ii) the appointment by the Company of a successor depositary and its
acceptance of such appointment as provided in the Deposit Agreement. The Depositary may at any time be removed by the Company by written
notice of such removal, which removal shall be effective on the later of (i) the 90th day after delivery thereof to the Depositary
(whereupon the Depositary shall be entitled to take the actions contemplated in Section 6.2 of the Deposit Agreement), or (ii) upon the
appointment by the Company of a successor depositary and its acceptance of such appointment as provided in the Deposit Agreement. In case
at any time the Depositary acting hereunder shall resign or be removed, the Company shall use its best efforts to appoint a successor
depositary, which shall be a bank or trust company having an office in the Borough of Manhattan, the City of New York. Every successor
depositary shall be required by the Company to execute and deliver to its predecessor and to the Company an instrument in writing accepting
its appointment hereunder, and thereupon such successor depositary, without any further act or deed (except as required by applicable
law), shall become fully vested with all the rights, powers, duties and obligations of its predecessor (other than as contemplated in
Sections 5.8 and 5.9 of the Deposit Agreement). The predecessor depositary, upon payment of all sums due it and on the written request
of the Company, shall (i) execute and deliver an instrument transferring to such successor all rights and powers of such predecessor
hereunder (other than as contemplated in Sections 5.8 and 5.9 of the Deposit Agreement), (ii) duly assign, transfer and deliver all right,
title and interest to the Deposited Securities to such successor, and (iii) deliver to such successor a list of the Holders of all outstanding
ADSs and such other information relating to ADSs and Holders thereof as the successor may reasonably request. Any such successor depositary
shall promptly provide notice of its appointment to such Holders. Any corporation into or with which the Depositary may be merged or consolidated
shall be the successor of the Depositary without the execution or filing of any document or any further act.
(22) Amendment/Supplement. Subject to the terms and conditions of this paragraph 22, and Section 6.1 of the Deposit Agreement
and applicable law, this ADR and any provisions of the Deposit Agreement may at any time and from time to time be amended or supplemented
by written agreement between the Company and the Depositary in any respect which they may deem necessary or desirable without the prior
written consent of the Holders or Beneficial Owners. Any amendment or supplement which shall impose or increase any fees or charges (other
than charges in connection with foreign exchange control regulations, and taxes and other governmental charges, delivery and other such
expenses), or which shall otherwise materially prejudice any substantial existing right of Holders or Beneficial Owners, shall not, however,
become effective as to outstanding ADSs until the expiration of thirty (30) days after notice of such amendment or supplement shall have
been given to the Holders of outstanding ADSs. Notice of any amendment to the Deposit Agreement or any ADR shall not need to describe
in detail the specific amendments effectuated thereby, and failure to describe the specific amendments in any such notice shall not render
such notice invalid, provided, however, that, in each such case, the notice given to the Holders identifies a means for
Holders and Beneficial Owners to retrieve or receive the text of such amendment (i.e., upon retrieval from the Commission’s,
the Depositary’s or the Company’s website or upon request from the Depositary). The parties hereto agree that any amendments
or supplements which (i) are reasonably necessary (as agreed by the Company and the Depositary) in order for (a) the ADSs to be registered
on Form F-6 under the Securities Act or (b) the ADSs to be settled solely in electronic book-entry form and (ii) do not in either such
case impose or increase any fees or charges to be borne by Holders, shall be deemed not to materially prejudice any substantial rights
of Holders or Beneficial Owners. Every Holder and Beneficial Owner at the time any amendment or supplement so becomes effective shall
be deemed, by continuing to hold such ADSs, to consent and agree to such amendment or supplement and to be bound by the Deposit Agreement
and this ADR, if applicable, as amended or supplemented thereby. In no event shall any amendment or supplement impair the right of the
Holder to surrender such ADS and receive therefor the Deposited Securities represented thereby, except in order to comply with mandatory
provisions of applicable law. Notwithstanding the foregoing, if any governmental body should adopt new laws, rules or regulations which
would require an amendment of, or supplement to, the Deposit Agreement to ensure compliance therewith, the Company and the Depositary
may amend or supplement the Deposit Agreement and this ADR at any time in accordance with such changed laws, rules or regulations. Such
amendment or supplement to the Deposit Agreement and this ADR in such circumstances may become effective before a notice of such amendment
or supplement is given to Holders or within any other period of time as required for compliance with such laws, rules or regulations.
(23) Termination. The Depositary shall, at any time at the written direction of the Company, terminate the Deposit Agreement
by distributing notice of such termination to the Holders of all ADSs then outstanding at least thirty (30) days prior to the date fixed
in such notice for such termination. If ninety (90) days shall have expired after (i) the Depositary shall have delivered to the Company
a written notice of its election to resign, or (ii) the Company shall have delivered to the Depositary a written notice of the removal
of the Depositary, and, in either case, a successor depositary shall not have been appointed and accepted its appointment as provided
in Section 5.4 of the Deposit Agreement, the Depositary may terminate the Deposit Agreement by distributing notice of such termination
to the Holders of all ADSs then outstanding at least thirty (30) days prior to the date fixed in such notice for such termination. The
date so fixed for termination of the Deposit Agreement in any termination notice so distributed by the Depositary to the Holders of ADSs
is referred to as the “Termination Date”. Until the Termination Date, the Depositary shall continue to perform all
of its obligations under the Deposit Agreement, and the Holders and Beneficial Owners will be entitled to all of their rights under the
Deposit Agreement. If any ADSs shall remain outstanding after the Termination Date, the Registrar and the Depositary shall not, after
the Termination Date, have any obligation to perform any further acts under the Deposit Agreement, except that the Depositary shall, subject,
in each case, to the terms and conditions of the Deposit Agreement, continue to (i) collect dividends and other distributions pertaining
to Deposited Securities, (ii) sell securities and other property received in respect of Deposited Securities, (iii) deliver Deposited
Securities, together with any dividends or other distributions received with respect thereto and the net proceeds of the sale of any securities
or other property, in exchange for ADSs surrendered to the Depositary (after deducting, or charging, as the case may be, in each case,
the fees and charges of, and expenses incurred by, the Depositary, and all applicable taxes or governmental charges for the account of
the Holders and Beneficial Owners, in each case upon the terms set forth in Section 5.9 of the Deposit Agreement), and (iv) take such
actions as may be required under applicable law in connection with its role as Depositary under the Deposit Agreement. At any time after
the Termination Date, the Depositary may sell the Deposited Securities then held under the Deposit Agreement and shall after such sale
hold un-invested the net proceeds of such sale, together with any other cash then held by it under the Deposit Agreement, in an un-segregated
account and without liability for interest, for the pro - rata benefit of the Holders whose ADSs have not theretofore been surrendered.
After making such sale, the Depositary shall be discharged from all obligations under the Deposit Agreement except (i) to account for
such net proceeds and other cash (after deducting, or charging, as the case may be, in each case, the fees and charges of, and expenses
incurred by, the Depositary, and all applicable taxes or governmental charges for the account of the Holders and Beneficial Owners, in
each case upon the terms set forth in Section 5.9 of the Deposit Agreement), and (ii) as may be required at law in connection with the
termination of the Deposit Agreement. After the Termination Date, the Company shall be discharged from all obligations under the Deposit
Agreement, except for its obligations to the Depositary under Sections 5.8, 5.9 and 7.6 of the Deposit Agreement. The obligations under
the terms of the Deposit Agreement of Holders and Beneficial Owners of ADSs outstanding as of the Termination Date shall survive the Termination
Date and shall be discharged only when the applicable ADSs are presented by their Holders to the Depositary for cancellation under the
terms of the Deposit Agreement.
(24) Compliance with U.S. Securities Laws. Notwithstanding any provisions in this ADR or the Deposit Agreement to the contrary,
the withdrawal or delivery of Deposited Securities will not be suspended by the Company or the Depositary except as would be permitted
by Instruction I.A.(1) of the General Instructions to the Form F-6 Registration Statement, as amended from time to time, under the Securities
Act.
(25) Certain Rights of the Depositary. The Depositary, its Affiliates and their agents, on their own behalf, may own and
deal in any class of securities of the Company and its Affiliates and in ADSs.
(ASSIGNMENT AND TRANSFER SIGNATURE LINES)
FOR VALUE RECEIVED, the undersigned Holder hereby
sell(s), assign(s) and transfer(s) unto __________________ whose taxpayer identification number is _________________ and whose address
including postal zip code is ____________, the within ADS and all rights thereunder, hereby irrevocably constituting and appointing __________________
attorney-in-fact to transfer said ADS on the books of the Depositary with full power of substitution in the premises.
Dated: |
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Name: |
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By: |
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Title: |
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NOTICE: The signature of the Holder to this assignment must correspond with the name as written upon the face of the within instrument in every particular, without alteration or enlargement or any change whatsoever. |
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If the endorsement be executed by an attorney, executor, administrator, trustee or guardian, the person executing the endorsement must give his/her full title in such capacity and proper evidence of authority to act in such capacity, if not on file with the Depositary, must be forwarded with this ADR. |
__________________________ |
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SIGNATURE GUARANTEED |
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All endorsements or assignments of ADRs must be guaranteed by a member of a Medallion Signature Program approved by the Securities Transfer Association, Inc. |
EXHIBIT B
Form of Depositary Notice
[Preliminary]1
[final]2
DEPOSITARY NOTICE OF ADS RATIO CHANGE / REVERSE SPLIT
To Holders of American Depositary Shares (“ADSs”)
of Amarin Corporation plc
Company: |
Amarin Corporation plc, a company organized under the laws of England and Wales (the “Company”). |
Depositary: |
Citibank, N.A. |
Custodian: |
Citibank, N.A. – London Branch. |
Existing ADS-to-Share Ratio: |
Each ADS represents the right to receive one (1) fully paid ordinary share of the Company (the “Share(s)”). |
New ADS-to-Share Ratio: |
Each ADS represents the right to receive twenty (20) Shares. |
Deposit Agreement: |
Amended and Restated Deposit Agreement, dated as of November 4, 2011, by and among the Company, the Depositary, and the Holders and Beneficial Owners of ADSs issued thereunder, as amended and supplemented (the “Deposit Agreement”). |
ADS Symbol: |
AMRN.* |
Existing ADS ISIN: |
US0231112063.* |
New ADS ISIN: |
US0231114044.* |
Existing ADS CUSIP No.: |
023111206.* |
New ADS CUSIP No.: |
023111404.* |
Effective Date: |
[The later of (i) the date upon which the U.S. Securities and Exchange Commission (the “SEC”) declares effective the Post-Effective Amendment No. 1 to Registration Statement on Form F-6 and (ii) 30-days after the date of this notice]3 [April 11, 2025]4 (the “Effective Date”). |
ADS Books Closure to ADS Issuances and Cancellations: |
April 4, 2025 (5:00 p.m. New York City time) until April 11, 2025 (5:00 p.m. New York City time). |
*ADS Symbol, ADS ISINs and ADS CUSIP Nos.
are provided as a convenience only and without any liability for accuracy.
_______________________
1
To be used in Preliminary Notice
2 To be used in Final Notice
3
To be used in Preliminary Notice
4 To be used in Final Notice
[On March 12, 2025, the Depositary
notified holders and beneficial owners of ADSs that the Company and the Depositary have agreed to change the Existing ADS-to-Shares Ratio
(the “Prior Notice”). On the Effective Date, pursuant to the provisions of the
Deposit Agreement, the changes described in the Prior Notice will take effect as thirty (30) days will have elapsed from the date of the
Prior Notice.]5
[Pursuant to Section 6.1 of
the Deposit Agreement and by means of Amendment No. 1 to the Deposit Agreement (“Amendment No. 1”), the Company and
the Depositary have agreed to amend the Deposit Agreement, the form of ADR attached as Exhibit A to the Deposit Agreement, and
all issued and outstanding American Depositary Receipts (“ADRs”) to (i) change the Existing ADS-to-Share Ratio and
(ii) eliminate the Depositary’s ability to conduct Pre-Release Transactions. Amendment No. 1 will not become effective until the
Effective Date, and by continuing to hold any outstanding ADSs issued under the Deposit Agreement after the Effective Date, you will be
deemed to have agreed to be bound by Amendment No. 1. The Depositary shall arrange to have new ADRs printed that reflect the changes effected
by Amendment No. 1. If you hold ADRs issued prior to the Effective Date, your ADRs must be surrendered to Depositary for exchange. If
you hold ADSs in uncertificated form, you do not need to take any action.]6
The Existing ADS-to-Share
Ratio will change as of the Effective Date (the “ADS Ratio Change”) as follows:
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Existing ADS-to-Share Ratio: |
One (1) ADS to one (1) Share |
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New ADS-to-Share Ratio: |
One (1) ADS to twenty (20) Shares |
Following the Effective Date
for the ADS Ratio Change, each ADS will represent twenty (20) Shares.
As a result of the ADS Ratio
Change, the CUSIP number for the ADSs will change as follows:
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Existing ADS CUSIP No.: |
023111206 |
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New ADS CUSIP No.: |
023111404 |
In connection with the ADS
Ratio Change, Holders of ADSs will be entitled to receive one (1) new ADS for every twenty (20) existing ADSs held as of the Effective
Date.
ADSs held in The Depository
Trust Company (“DTC”)
You do not need to take any
action for existing ADSs held in DTC and by one of its participants (e.g., bank, broker, or other nominee). After the ADS Ratio Change,
the new ADSs will be credited to DTC in exchange for existing ADSs for distribution to DTC participants and their client accounts. DTC
participants and their clients are not required to take any affirmative actions to exchange existing ADSs for new ADSs.
_______________________
5 To be used in Final Notice
6
To be used in Preliminary Notice
ADSs held in uncertificated
form (other than in DTC).
You do not need to take any
action for existing ADSs held via the Direct Registration System. You will receive a statement from the Depositary specifying the applicable
number of ADSs, after the ADS Ratio Change, that have been registered in your name.
ADSs held in certificated
form.
If you hold certificated ADSs
or ADRs, you will need to complete, sign, and deliver to the Depositary a Letter of Transmittal (the “Letter of Transmittal”)
in accordance with the instructions therein (the Letter of Transmittal will be mailed by the Depositary to all certificated holders after
the Effective Date). Upon receipt of a duly completed and executed Letter of Transmittal and the applicable share certificate(s) issued
in your name, the Depositary will register in your name uncertificated ADSs reflecting the New ADS-to-Share Ratio. You will receive a
statement from the Depositary specifying the applicable number of ADSs that have been registered in your name.
General
No fractional ADSs will be
issued. Cash in lieu of fractional entitlements to ADSs will be distributed at a rate based upon the net proceeds received by the Depositary
for the sale of the aggregate of the fractional ADS entitlements.
The Depositary has filed (x)
a form of Amendment No. 1 [to the Deposit Agreement]7,
and (y) a form of ADR that reflects the new ADS-to-Share ratio with the [SEC]8[U.S.
Securities and Exchange Commission (the “SEC”)]9
under cover of Post-Effective Amendment No. 1 to Registration Statement on Form F-6. Copies of the filings and of the Deposit Agreement
are available at the principal offices of the Depositary at 388 Greenwich Street, New York, NY 10013 and can also be retrieved from the
SEC’s website at www.sec.gov under Registration Number 333-228591.
If you have any questions
about the above amendment and exchange, please call Citibank ADR Shareholder Services at 1-877-248-4237.
Date: [March 12, 2025]10
[April 1, 2025]11 Citibank,
N.A. as Depositary
_______________________
7
To be used in Final Notice
8
To be used in Preliminary Notice
9
To be used in Final Notice
10
To be used in Preliminary Notice
11
To be used in Final Notice
B-3
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