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Moderna Inc

Moderna Inc (MRNA)

69.86
-2.13
(-2.96%)
Closed September 19 4:00PM
70.30
0.44
(0.63%)
After Hours: 7:58PM

Calls

StrikeBid PriceAsk PriceLast PriceMidpointChangeChange %VolumeOPEN INTLast Trade
60.008.3511.6510.5510.00-2.55-19.47 %6819/18/2024
61.007.259.308.828.2750.000.00 %04-
62.006.258.006.007.1250.000.00 %012-
63.005.408.759.607.0750.353.78 %1459/18/2024
64.004.357.659.156.000.505.78 %61779/18/2024
65.004.705.505.605.10-1.50-21.13 %123069/18/2024
66.004.054.204.754.125-1.35-22.13 %73509/18/2024
67.002.983.354.003.165-1.15-22.33 %755309/18/2024
68.002.403.952.853.175-1.55-35.23 %172,3329/18/2024
69.001.012.802.161.905-1.36-38.64 %933,3349/18/2024
70.001.301.481.551.39-1.39-47.28 %5662,1669/18/2024
71.000.561.100.960.83-1.37-58.80 %3577449/18/2024
72.000.600.770.610.685-1.18-65.92 %1,0262,6719/18/2024
73.000.390.440.410.415-0.98-70.50 %4787029/18/2024
74.000.220.290.320.255-0.65-67.01 %5034879/18/2024
75.000.150.210.190.18-0.55-74.32 %1,2632,8759/18/2024
76.000.120.300.140.21-0.40-74.07 %2484,0199/18/2024
77.000.090.120.100.105-0.25-71.43 %1406979/18/2024
78.000.040.120.120.08-0.18-60.00 %1786109/18/2024
79.000.030.100.070.065-0.15-68.18 %3257959/18/2024

Empower your portfolio: Real-time discussions and actionable trading ideas.

Puts

StrikeBid PriceAsk PriceLast PriceMidpointChangeChange %VolumeOPEN INTLast Trade
60.000.010.050.040.030.0133.33 %1171,8299/18/2024
61.000.020.260.050.140.000.00 %84659/18/2024
62.000.030.200.030.115-0.01-25.00 %301,3309/18/2024
63.000.030.250.050.14-0.03-37.50 %24139/18/2024
64.000.050.110.060.08-0.03-33.33 %492739/18/2024
65.000.110.140.140.1250.0216.67 %2412,1349/18/2024
66.000.200.240.210.220.0210.53 %615959/18/2024
67.000.340.540.340.440.0725.93 %3525709/18/2024
68.000.570.650.650.610.2044.44 %3129659/18/2024
69.000.920.990.960.9550.3045.45 %1573589/18/2024
70.001.371.721.431.5450.5257.14 %5985,0539/18/2024
71.001.702.551.962.1250.7055.56 %1332009/18/2024
72.002.352.822.662.5850.9152.00 %2444629/18/2024
73.003.353.753.383.551.0243.22 %403259/18/2024
74.002.056.004.364.0251.1234.57 %543219/18/2024
75.004.909.404.937.150.8621.13 %281,7279/18/2024
76.006.0510.005.868.0250.9619.59 %246139/18/2024
77.006.8511.506.559.1751.2122.66 %14349/18/2024
78.007.659.607.418.6252.1641.14 %132509/18/2024
79.005.0010.958.767.9750.8811.17 %22189/18/2024

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MRNA Discussion

View Posts
axelvento axelvento 3 days ago
Buy the Fear, Sell the Greed$$$$$$
👍️0
Vexari Vexari 3 days ago
That is the question

Why does the NIH own half

Of all MRNA injections
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axelvento axelvento 4 days ago
I do not know, what do you think? "It has to bounce back"
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axelvento axelvento 4 days ago
Moderna was getting too big, too fast. "The size of our late-stage pipeline combined with the challenge of launching products means we must now focus on delivering these 10 products to patients, slow down the pace of new R&D investment, and build our commercial business," said chief executive officer Stéphane Bancel.
This is after -- just last year -- forecasting the launch of as many as 15 new products over the next five years.

THE WRITING IS ON THE WALL

https://www.fool.com/investing/2024/09/14/after-moderna-shocking-news-is-stock-a-buy-or-sell/
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Monksdream Monksdream 4 days ago
MRNA how much lower can it go
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axelvento axelvento 5 days ago
https://www.oncologypipeline.com/apexonco/accelerated-path-closes-modernamercks-immunotherapy

The journey is long and full of dangers.

The FDA’s issue with mRNA-4157 is unclear but it’s possible that, with the melanoma sector already well served, the agency is waiting for a clear overall survival benefit.
👋 1 👍️ 1
axelvento axelvento 5 days ago
Scientists are hailing a new dawn in cancer treatment after a groundbreaking vaccine stopped the growth of tumours and the development of new ones in half of patients in the first-in-human study.

The mRNA-4359 vaccine works by teaching the immune system to identify and attack cancer cells

The work
https://www.msn.com/en-gb/health/other/cancer-breakthrough-as-vaccine-revs-up-immune-system-to-stop-tumours-and-destroy-disease-in-world-first/ar-AA1qwwX1?apiversion=v2&noservercache=1&domshim=1&renderwebcomponents=1&wcseo=1&batchservertelemetry=1&noservertelemetry=1
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axelvento axelvento 5 days ago
https://www.modernatx.com/en-US/media-center/all-media/blogs/strategic-priorities-at-R-D-Day
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axelvento axelvento 5 days ago
Moderna is due to present the data from the first-in-human study of mRNA-4359 on 14 September at the European Society of Medical Oncology meeting, taking place between 13 September and 16 September in Barcelona, Spain.
👍️0
jondoeuk jondoeuk 5 days ago
mRNA-4359 data https://finance.yahoo.com/news/esmo-moderna-mrna-solid-tumour-101238212.html
👍️0
Vexari Vexari 5 days ago
What's in this vaccine?

That shows positive results

What makes it work

Otherwise

Why be a mouthpiece
🃏 1 👎️ 1 🕳️ 1 🤪 1 0️⃣ 1
DewDiligence DewDiligence 6 days ago
Provided that the phase-3 trial is successful. MRNA acknowledged yesterday that FDA accelerated approval for mRNA-4147 based on phase-2 data is no longer under consideration
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axelvento axelvento 6 days ago
Moderna to launch skin cancer vaccine as soon as 2025: CEO

https://asia.nikkei.com/Business/Pharmaceuticals/Moderna-to-launch-skin-cancer-vaccine-as-soon-as-2025-CEO
👍️0
axelvento axelvento 6 days ago
Cancer vaccine breakthrough as tests show positive results on patients with tumours
The jab, known as mRNA-4359, is developed by Moderna

Researchers found tumours did not grow and no new tumours appeared in eight of the 16 patients who were evaluated

Scientists use a tumour sample, along with DNA sequencing and artificial intelligence, to create a jab specific to the patient’s tumour.

https://www.independent.co.uk/news/health/cancer-vaccine-jab-lung-mrna4359-b2611858.html
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DewDiligence DewDiligence 7 days ago
MRNA—(-17%)—cuts costs, pares pipeline—investors unimpressed:

https://finance.yahoo.com/news/moderna-r-d-day-highlights-100000130.html

Annual R&D expenses, expected to be $4.7B in 2024, will be reduced to $3.6-3.8B by 2027. Cumulatively, R&D expenses during the 2025-2028 period will be reduced by 20%. Such a cutback is apparently too little and too slow to placate investors.

Perhaps more important, MRNA now says it expects to reach break-even cash flow in 2028—two years later then the previous guidance.

Moreover, MRNA issued 2025 revenue guidance of $2.5-3.5B, which is down from the (previously reduced) 2024 guidance of $3.0-3.5B (#msg-174849487).

Please see #msg-175048423 for related info.
👍️0
axelvento axelvento 7 days ago
Focuses on ten product approvals through 2027

"Moderna now has five respiratory vaccines with positive Phase 3 results and expects to submit three for approval this year. In addition, we have five non-respiratory products in pivotal studies across cancer, rare diseases and latent vaccines with potential for approval by 2027. Our demonstrated probability of success in R&D has been higher than industry standards at every stage of development," said Stéphane Bancel, CEO of Moderna. "The size of our late-stage pipeline combined with the challenge of launching products means we must now focus on delivering these 10 products to patients, slow down the pace of new R&D investment, and build our commercial business."



Moderna's broad clinical success and recent commercial challenges necessitate a more selective and paced approach to its research and development investment. Through portfolio prioritization and cost efficiencies, the Company expects to reduce annual research and development expense by approximately $1.1 billion starting in 2027. During this time, Moderna will expand its commercial portfolio into oncology, rare diseases, and first-in-class non-respiratory vaccines. The Company expects this strategy to yield 10 product approvals over the next three years.

Cash and Investments: Year-end cash and investments for 2025 are projected to be approximately $6 billion.

Moderna plans to break even on an operating cash cost basis (which excludes stock-based compensation, depreciation and amortization expense) with $6 billion in revenue. The Company expects to achieve this in 2028. The Company has sufficient capital to fund its plans until achieving break even on a cash cost basis without raising additional equity.



https://investors.modernatx.com/news/news-details/2024/Moderna-RD-Day-Highlights-Progress-and-Strategic-Priorities/default.aspx


launch pad$$$$$$$$
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Vexari Vexari 1 week ago
So much noise

Can't pay attention
🌬️ 1 👎️ 1 💊 1 🗑️ 1 😎 1 🤪 1
Vexari Vexari 1 week ago
Suffering from

A medical coincidence

From the other side
🕳️ 1 🗑️ 1 😎 1 🧻 1 🪠 1 0️⃣ 1
axelvento axelvento 1 week ago
Milestone marks a significant step toward producing mRNA vaccines in Canada by 2025


https://investors.modernatx.com/news/news-details/2024/Modernas-Canadian-Manufacturing-Facility-Receives-Drug-Establishment-License-From-Health-Canada/default.aspx
👍️ 1 😀 1
DewDiligence DewDiligence 2 weeks ago
MRNA spends far too much, says WSJ’s “Heard-on-the-Street” column:

https://www.wsj.com/finance/stocks/pandemic-darling-moderna-needs-a-reality-check-3c375b0e Moderna’s massive pipeline of 45 therapies and vaccines will be the focus of its R&D day next Thursday. But what investors most want to see is that program being trimmed.

Moderna is now bleeding cash at a worrying pace. Last year it reported a $4.7 billion net loss, and it is now on track to lose at least another $3 billion this year, according to analyst estimates compiled by FactSet. The company has made the case that it should begin to break even by 2026. But that isn’t looking likely given the slow uptake of the company’s second product, an RSV vaccine that has struggled to gain market share against shots from Pfizer and GSK.

… The good news is that, given the size of the company’s massive pipeline, there is plenty of room to find something like $1 billion in cuts.
👍️0
axelvento axelvento 2 weeks ago
Cancer Vaccines Industry Research Report 2024: Market Poised for Exponential Growth with a Projected Value of $6.7 Billion by 2032

https://www.globenewswire.com/news-release/2024/09/05/2941536/0/en/Cancer-Vaccines-Industry-Research-Report-2024-Market-Poised-for-Exponential-Growth-with-a-Projected-Value-of-6-7-Billion-by-2032.html
👍️ 2 💪 2
axelvento axelvento 2 weeks ago
$ANIX
👋 1 👍️ 1
axelvento axelvento 2 weeks ago
Study shows that vaccination against RSV lowers the risk of hospitalization in people over 60

https://medicalxpress.com/news/2024-09-vaccination-rsv-lowers-hospitalization-people.html#google_vignette
👍️ 1 🤙 1
axelvento axelvento 2 weeks ago
Moderna’s First mRNA Mpox Vaccine Beats Licensed Rival Shots In Early Testing
https://www.forbes.com/sites/roberthart/2024/09/04/modernas-first-mrna-mpox-vaccine-beats-licensed-rival-shots-in-early-testing/
👌 1 👍️ 1
Vexari Vexari 2 weeks ago
Do viruses exist?

The essence of science

Called the null hypothesis

What is the issue
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axelvento axelvento 2 weeks ago
Mother's RSV vaccine plea after baby's virus death-

https://www.bbc.com/news/articles/c5y3kvl9k0wo
👍️0
axelvento axelvento 3 weeks ago
Here we go!
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DewDiligence DewDiligence 3 weeks ago
Typo correction—The header of #msg-174969830 should say, "FDA approves PFE, MRNA COVID vaccines targeting KP.2 variant."
👍️0
axelvento axelvento 3 weeks ago
Patient in the UK is the first to receive a novel lung cancer vaccine
Unlike chemotherapy, the vaccine reduces the risk of toxicity to healthy, non-cancerous cells by enhancing the immune responses to target cancer cells, researchers said

$BNTX
https://www.insideprecisionmedicine.com/topics/oncology/global-trial-of-biontechs-mrna-based-lung-cancer-vaccine-launches/
👌 1 👍️ 1
Vexari Vexari 3 weeks ago
Which was created through the vaccines
The First mRNA Vaccine for Melanoma WHO controls the FDA

Where does that go

Create the problem

Watch the reaction

Afford the solution

Simple business plan
🕳️ 1 🗑️ 1 😎 1 🤪 1 🧻 1 ⬇️ 1
axelvento axelvento 4 weeks ago
Coming Soon: The First mRNA Vaccine for Melanoma........

Moderna and Merck have presented promising results from their phase 2b clinical trial that investigated a combination of a messenger RNA (mRNA) vaccine and a cancer drug for the treatment of melanoma.

Is mRNA set to shake up the world of cancer treatment? This is certainly what Moderna seems to think; the pharmaceutical company has published the results of a phase 2b trial combining its mRNA vaccine (mRNA-4157 [V940]) with Merck's cancer drug KEYTRUDA. While these are not the final results but rather mid-term data from the 3-year follow-up, they are somewhat promising. The randomized KEYNOTE-942/mRNA-4157-P201 clinical trial involves patients with high-risk (stage III/IV) melanoma following complete resection.

Relapse Risk Halved
Treatment with mRNA-4157 (V940) in combination with pembrolizumab led to a clinically meaningful improvement in recurrence-free survival, reducing the risk for recurrence or death by 49%, compared with pembrolizumab alone. The combination of mRNA-4157 (V940) with pembrolizumab also continued to demonstrate a meaningful improvement in distant metastasis-free survival compared with pembrolizumab alone, reducing the risk of developing distant metastasis or death by 62%. "The KEYNOTE-942/mRNA-4157-P201 study was the first demonstration of efficacy for an investigational mRNA cancer treatment in a randomized clinical trial and the first combination therapy to show a significant benefit over pembrolizumab alone in adjuvant melanoma", said Kyle Holen, MD, Moderna's senior vice president, after presenting these results.

Side Effects
The combined treatment also did not demonstrate more significant side effects than pembrolizumab alone. The number of patients reporting treatment-related adverse events of grade 3 or greater was similar between the arms (25% for mRNA-4157 [V940] with pembrolizumab vs 20% for KEYTRUDA alone). The most common adverse events of any grade attributed to mRNA-4157 (V940) were fatigue (60.6%), injection site pain (56.7%), and chills (49%). Based on data from the phase 2b KEYNOTE-942/mRNA-4157-P201 study, the US Food and Drug Administration and European Medicines Agency granted breakthrough therapy designation and recognition under the the Priority Medicines scheme, respectively, for mRNA-4157 (V940) in combination with KEYTRUDA for the adjuvant treatment of patients with high-risk melanoma.

Phase 3 Trial
In July, Moderna and Merck announced the launch of a phase 3 trial, assessing "mRNA-4157 [V940] in combination with pembrolizumab as adjuvant treatment in patients with high-risk resected melanoma [stages IIB-IV]." Stéphane Bancel, Moderna's director general, believes that an mRNA vaccine for melanoma could be available in 2025.
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axelvento axelvento 4 weeks ago
Moderna Receives European Commission Approval for RSV Vaccine mRESVIA(R)


https://investors.modernatx.com/news/news-details/2024/Moderna-Receives-European-Commission-Approval-for-RSV-Vaccine-mRESVIAR/default.aspx
👍️0
DewDiligence DewDiligence 4 weeks ago
PFE/MRNA/NVAX—Street consensus sales for 2H24 COVID vaccines:

https://www.barrons.com/articles/fda-approves-updated-covid-19-shots-pfizer-moderna-5d1d1229 Wall Street analysts expect roughly $2.5 billion in sales of Moderna’s Covid-19 vaccine in the second half of the year, according to FactSet, while they have penciled in $4.5 billion in sales for Pfizer’s version. From Novavax, they expect sales in the second half of just $210 million. The $4.5B 2H24 figure above for PFE is consistent with PFE’s own guidance of $5.0B for the full year (#msg-174835917), since PFE sold $550M of COVID vaccines in 1H24.

MRNA has not given 2024 guidance for COVID-vaccine sales specifically; rather, MRNA guided to $3.0-$3.5B of sales for COVID and RSV vaccines combined (#msg-174849487). In 1H24, MRNA sold $350M of COVID vaccines and its RSV vaccine had not yet launched.
👍️0
DewDiligence DewDiligence 4 weeks ago
FDA approves PFE, COVID vaccines targeting KP.2 variant:

https://finance.yahoo.com/news/pfizer-biontech-receive-u-fda-181500674.html (PFE)

https://finance.yahoo.com/news/moderna-receives-u-fda-approval-174700629.html (MRNA)

NVAX’s updated COVID vaccine is not ready yet.
👍️0
axelvento axelvento 4 weeks ago
FDA approved RNA Drugs: 21

RNA therapeutics in targeting GPCRs

https://www.cell.com/action/showPdf?pii=S2162-2531%2824%2900082-9
👍️0
axelvento axelvento 1 month ago
Moderna was the most shorted healthcare company at July-end, with short interest at 6.69%
👍️0
axelvento axelvento 1 month ago
https://www.washingtonpost.com/health/2024/08/16/new-covid-vaccine-pfizer-moderna-flirt-variant/
👍️0
axelvento axelvento 1 month ago
The good news about an mRNA vaccine is that if necessary, it could easily be adapted to work against any new
mpox variants that emerge and they can rapidly be manufactured.
👍️0
axelvento axelvento 1 month ago
mpox Curious about the status of @moderna_tx’s #mRNA #vaccines for #mpox and #smallpox?

With the ongoing #mpox outbreak, it’s crucial to know how the Phase 1/2 Clinical Trial that began in the UK earlier this year is progressing. #vaccineshttps://t.co/NrSZPvoPv1— Krutika Kuppalli, MD FIDSA (@KrutikaKuppalli) August 17, 2024
👍️0
axelvento axelvento 1 month ago
Cancer patients to join personalised vaccine trial

https://www.bbc.com/news/articles/c5yk7m9x8nmo
👍️0
Vexari Vexari 1 month ago
Cause unknown

Sudden death "epidemic"

Is "national security issue"
🎃 1 👎️ 1 💊 1 🗑️ 1 🧻 1
axelvento axelvento 1 month ago
sometimes they come back
https://www.wsws.org/en/articles/2024/08/13/qmqx-a13.html

The math is not an opinion!
👍️0
spartex spartex 1 month ago
Funny, the population of the USA is 333.3 million (2022).

One million infected is 1 in 333 people.

That X poster for the Covid19 appears to have made a mistake........or they have terrible math skills.........or they have an agenda.
👍️ 1
Vexari Vexari 1 month ago
All labs cannot be wrong

Characteristics and behaviors distinguishing
(1:52:35)

Those in positions of power

BaggyPants
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axelvento axelvento 1 month ago
Personalized Cancer Vaccines Are the Future of Cancer Treatment. Here’s How They Work

https://www.verywellhealth.com/the-future-of-cancer-treatment-personalized-vaccines-8692668
👍️0
axelvento axelvento 1 month ago
KEYNOTE-603 Data Further Bolster Merck, Moderna's Bespoke mRNA Vaccine in NSCLC, Melanoma

https://www.precisionmedicineonline.com/precision-oncology/keynote-603-data-further-bolster-merck-modernas-bespoke-mrna-vaccine-nsclc
👍️0
gapole gapole 1 month ago
Great podcast. I will look him up
👍️0
axelvento axelvento 1 month ago
⚠️ BREAKING

U.S. Daily COVID-19 Infections Reach 1 Million

Currently, 1 in every 33 people in the U.S. is infected with COVID-19, a staggering figure that marks a 74% increase over the average infection rates of the past year. pic.twitter.com/WDXV50P5qb— SARS‑CoV‑2 (COVID-19) (@COVID19_disease) August 10, 2024
👍️0
Acme Investments Acme Investments 1 month ago
Might hit 78 before the next bounce!!
👍️0
axelvento axelvento 1 month ago
sometimes they come back
⚠️ BREAKING

🇨🇳 China Faces New COVID-19 Surge with Recombinant Variant XDV.1

Recent reports from China reveal a concerning resurgence of COVID-19 driven by a new recombinant variant, XDV.1, which combines Delta and Omicron strains. pic.twitter.com/hDLnOgqBUt— SARS‑CoV‑2 (COVID-19) (@COVID19_disease) August 9, 2024
👍️ 1

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