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      6. Lyell Immunopharma Inc (LYEL)

      7. Lyell Immunopharma Inc (LYEL) News

      Lyell Immunopharma Inc

      Lyell Immunopharma Inc (LYEL)

      NASDAQ
      1.745
      0.025
      ( 1.45% )
      Updated: 09:49:22
      Delayed by 15 minutes

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      LYEL News

      Official News Only

      Form 8-K - Current report
      Edgar (US Regulatory)
      June 14 2024
      LYEL (1.45%)

      Form 424B5 - Prospectus [Rule 424(b)(5)]
      Edgar (US Regulatory)
      May 06 2024
      LYEL (1.45%)

      Form 10-Q - Quarterly report [Sections 13 or 15(d)]
      Edgar (US Regulatory)
      May 06 2024
      LYEL (1.45%)

      Form 8-K - Current report
      Edgar (US Regulatory)
      May 06 2024
      LYEL (1.45%)

      Form 8-K - Current report
      Edgar (US Regulatory)
      February 28 2024
      LYEL (1.45%)

      Form 4 - Statement of changes in beneficial ownership of securities
      Edgar (US Regulatory)
      February 13 2024
      LYEL (1.45%)

      Form 4 - Statement of changes in beneficial ownership of securities
      Edgar (US Regulatory)
      February 13 2024
      LYEL (1.45%)

      Form 4 - Statement of changes in beneficial ownership of securities
      Edgar (US Regulatory)
      February 13 2024
      LYEL (1.45%)

      LYEL Discussion

      View Posts
      jondoeuk jondoeuk 1 month ago
      (OT) Dr Restifo is Co-founder and Chief Scientist at Marble Therapeutics. From this: ''At Marble Therapeutics, he is working to figure out how to rewind the epigenetic clock on these cells, using any means possible. The company started out with a focus on skin rejuvenation, adds CEO Denitsa Milanova, but expanded to also work on adoptive cell therapy to prove their platform works.'' https://web.archive.org/web/20231218233715/https://www.nature.com/articles/d41573-023-00206-6

      They have a license for TIL plus a neoantigen vaccine https://www.federalregister.gov/documents/2024/02/07/2024-02491/prospective-grant-of-an-exclusive-patent-license-vaccine-augmented-adoptive-cell-therapy-for-the

      Preclinical data on the vaccine https://jitc.bmj.com/content/11/Suppl_1/A418
      🎯 1 👍️ 1
      glenn1919 glenn1919 3 months ago
      LYEL.....................................https://stockcharts.com/h-sc/ui?s=LYEL&p=W&b=5&g=0&id=p86431144783
      👍️0
      Monksdream Monksdream 3 months ago
      LYEL active in the Gaucho session

      👍️0
      jondoeuk jondoeuk 4 months ago
      Tempting but I will remain on the sidelines.
      👍️0
      Monksdream Monksdream 4 months ago
      LYEL under $3
      👍️0
      glenn1919 glenn1919 4 months ago
      LYEL..................................https://stockcharts.com/h-sc/ui?s=LYEL&p=W&b=5&g=0&id=p86431144783
      👍️0
      jondoeuk jondoeuk 8 months ago
      They could be working on this https://ash.confex.com/ash/2023/webprogram/Paper182417.html
      👍️0
      jondoeuk jondoeuk 10 months ago
      Upcoming https://www.globenewswire.com/news-release/2023/09/27/2750444/0/en/Lyell-Immunopharma-Announces-the-Acceptance-of-Six-Abstracts-for-Presentation-at-2023-Society-for-Immunotherapy-of-Cancer-SITC-Annual-Meeting.html
      👍️0
      Monksdream Monksdream 10 months ago
      LYEL new 52 week low
      👍️0
      jondoeuk jondoeuk 1 year ago
      LYL119 https://annualmeeting.asgct.org/abstracts/abstract-details?abstractId=13739
      👍️0
      jondoeuk jondoeuk 1 year ago
      Preclinical data from another group (LYL119 will be NR4A3-deficient) https://www.biorxiv.org/content/10.1101/2023.04.21.537841v1.full
      👍️0
      glenn1919 glenn1919 1 year ago
      LYEL..........................https://stockcharts.com/h-sc/ui?s=LYEL&p=W&b=5&g=0&id=p86431144783
      👍️0
      jondoeuk jondoeuk 2 years ago
      The FDA has cleared an IND for LYL845. The PhI trial will initially enroll patients with relapsed and/or refractory metastatic or locally advanced melanoma and subsequently expand into NSCLC and CRC. Initial data presentation is expected in 2024.
      👍️0
      jondoeuk jondoeuk 2 years ago
      SITC titles

      NR4A3 gene editing and c-Jun overexpression synergize to limit exhaustion and enhance functional activity of ROR1 CAR T cells in vitro and in vivo

      Engineering potent CAR T-cell therapies by controlling T-cell activation signaling parameters using the Stim-R™ technology, a programmable synthetic cell-signaling platform

      The Epi-R™ technology produces a polyclonal TIL product (LYL845) with diverse tumor-reactive clones that have stem-like qualities and anti-tumor function

      The Epi-R™ technology produces a polyclonal TIL product (LYL845) with a greater expansion success rate across hot and cold tumors, improved product phenotype, and maintenance of TCR diversity

      Increased potency and functional persistence in vitro of a next-generation NY-ESO-1-specific TCR therapy incorporating Gen-R™ genetic reprogramming technology
      👍️0
      NY1972 NY1972 2 years ago
      recent technical advances using culture conditions with IL-7/IL-15 and
      the addition of IL-21 may enhance the enrichment for TSCM cells
      in the final CART product (74–76), which can be further increased
      with the addition of drugs blocking T-cell differentiation, such as
      glycogen synthase-3 inhibitors (77). Nevertheless, robust clinical grade protocols for generating TSCM-enriched CART products
      have not been developed so far. Recently, a few CART19 clinical
      trials for DLBCL have been conducted in which CART products
      were manufactured from CD62L+ isolated T cells to generate
      cellular products enriched for TCM cells (21, 78); however, due to
      prolonged culture conditions, enrichment for TSCM and TCM
      subsets in the infused product could not be demonstrated

      https://www.frontiersin.org/articles/10.3389/fimmu.2022.904497/full
      👍️0
      jondoeuk jondoeuk 2 years ago
      The AEs from the LD chemo*. I expect more data (dose expansion is ongoing) from them at ASH. As for NVS, a pivotal trial is planned and DL2 (12.5M) is the recommended dose.

      * Some very early clinical data testing an anti-GD2 CAR-T with constitutive signaling from an engineered IL-7 receptor
      👍️0
      NY1972 NY1972 2 years ago
      Thanks for the link.
      Most commonly reported grade 3/4 AEs were neutrophil count decrease (6/9, 67%), anemia (5/9, 56%), thrombocytopenia (2/9,22%), platelet count decrease (2/9, 22%) and no infection was reported. Complete response rate(CRR) was 78%

      Compared to T-Charge
      http://www.koreabiomed.com/news/articleView.html?idxno=12767

      👍️0
      jondoeuk jondoeuk 2 years ago
      For Epi-R, they use media with high concentrations of potassium (as well as multiple cytokines). As for that, T-Charge or BE, I think a product with mostly ''stem-like'' cells and additional edits will be needed. But it doesn't have to be the latter, as shRNA can be used. Here are some clinical data on an anti-CD19 CAR-T with knock-down of both PD-1 and TIGIT https://ascopubs.org/doi/abs/10.1200/JCO.2022.40.16_suppl.7522
      👍️0
      NY1972 NY1972 2 years ago
      Which will perform better ? BE with 7,8 edits on many genes, Epi secret sauce
      or T-Charge which seems to add a CAR only to starting material in order to retain CD4/CD8 ratio.
      YTB323 CAR-T cell products generated via this novel expansionless manufacturing process retained the immunophenotype of the input leukapheresis materia
      👍️0
      jondoeuk jondoeuk 2 years ago
      That depends. Typically, the more the cells expand during manufacturing, the more they differentiate. In the case of ALLO, it seems most are effector memory (manufacturing time is ~19 days and there are a number of steps involved). LYEL refer to this as the expansion/quality paradox. With Epi-R, they have shown they can expand TCR-T cells up to 18 billion by day ten. In addition, these cells are over 94% viable and maintain their ''stem-like'' qualities.
      👍️0
      NY1972 NY1972 2 years ago
      Do you need Epigenetic Reprogramming if pts can be treated with healthy, young donor T cells?
      👍️0
      jondoeuk jondoeuk 2 years ago
      ISSCR poster https://ir.lyell.com/static-files/971404cb-28eb-46fc-839f-b20735899373
      👍️0
      jondoeuk jondoeuk 2 years ago
      Posters https://ir.lyell.com/static-files/d3a3d05c-1b39-4092-bf82-a486933bc268

      https://ir.lyell.com/static-files/6014be8d-4e9d-499b-a496-513d2962f3e4
      👍️0
      jondoeuk jondoeuk 2 years ago
      1115: Epigenetic Reprogramming (Epi-R™) Yields T-Cell Receptor Products with Improved Stemness, Metabolic Fitness, and Functional Activity in the Presence of Persistent Antigen Exposure https://annualmeeting.asgct.org/abstracts/abstract-details?abstractId=2014

      661: Preclinical Development of LYL797, a ROR1-Targeted CAR T-Cell Therapy Enhanced with Genetic and Epigenetic Reprogramming for Solid Tumors https://annualmeeting.asgct.org/abstracts/abstract-details?abstractId=1597
      👍️0
      jondoeuk jondoeuk 2 years ago
      GSK has updated the master protocol for their next generation constructs to include a third arm with GSK4427296 https://clinicaltrials.gov/ct2/show/NCT04526509

      This uses Epi-R.
      👍️0
      jondoeuk jondoeuk 2 years ago
      AACR poster https://ir.lyell.com/static-files/ad2cd8dc-b41b-4536-a854-c4d1246422e6
      👍️0
      jondoeuk jondoeuk 2 years ago
      The PhI (n=54) of LYL797 has now been listed. The dose-escalation phase (TNBC only) will investigate four dose levels to determine the recommended RP2D. The dose expansion will enroll both TNBC and NSCLC.
      👍️0
      jondoeuk jondoeuk 3 years ago
      A new review https://www.sciencedirect.com/science/article/pii/S0952791521001278
      👍️0
      jondoeuk jondoeuk 3 years ago
      Morgan Stanley webcast https://morganstanley.webcasts.com/viewer/event.jsp?ei=1488969&tp_key=3cedc4a917
      👍️0
      jondoeuk jondoeuk 3 years ago
      New deck https://ir.lyell.com/static-files/96379999-4d8e-466b-a5d5-44f5f6f88583
      👍️0

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