FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Ayer Capital Management, LP

2. Date of Event Requiring Statement (MM/DD/YYYY)
5/31/2012 

3. Issuer Name and Ticker or Trading Symbol

Lion Biotechnologies, Inc. [GNBP]

(Last)        (First)        (Middle)

230 CALIFORNIA, SUITE 600, 

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                            ___ X ___ 10% Owner
_____ Officer (give title below)          _____ Other (specify below)

(Street)

SAN FRANCISCO, CA 94111       

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed (MM/DD/YYYY)

5/31/2013 

6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person


Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common stock   312500   I   See Footnote   (1) (2)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Warrant (contains 4.9% blocker)   (3) 7/26/2011   7/26/2016   Common stock   2400000   $1.25   I   See Footnote   (1) (2)
Warrant (contains 4.9% blocker)   (3) 2/20/2012   2/20/2017   Common stock   960000   $1.25   I   See Footnote   (1) (2)
Convertible Note (contains 4.9%)   (3) 7/26/2011   11/30/2012   Common stock   $3000000   $1.25   I   See Footnote   (1) (2)
Corporate Loan   5/3/2012   6/30/2012   Common Stock   $1100000   $1.25   I   See Footnote   (1) (2)

Explanation of Responses:
( 1)  These securities are held by investment funds and a managed account, the investment advisor of which is Ayer Capital Management, LP (the "Advisor"), ACM Capital Partners, LLC ("ACM")is the General Partner of the Advisor, Ayer Capital Partners, LLC (the "GP") is the General Partner of the investment funds. Mr. Venkatesan is the managing member of ACM and the General Partner of the GP.
( 2)  Each of the Advisor, ACM, the GP, and Mr. Venkatesan disclaims beneficial ownership of these securities except to the extent of its or his pecuniary interest thereof, and the filing of this report shall not be deemed an admission of beneficial ownership for purposes of Section 16 or for any other purpose.
( 3)  Each of the derivative securities listed above cannot be exercised or converted into more than 4.9% of the outstanding shares of the issuer's common stock, pursuant to written agreement with issuer.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Ayer Capital Management, LP
230 CALIFORNIA, SUITE 600
SAN FRANCISCO, CA 94111

X

Ayer Capital Partners, LLC
230 CALIFORNIA, SUITE 600
SAN FRANCISCO, CA 94111

X

ACM Capital Partners, LLC
230 CALIFORNIA, SUITE 600
SAN FRANCISCO, CA 94111

X

Venkatesan Jay
230 CALIFORNIA STREET
SUITE 600
SAN FRANCISCO, CA 94111

X


Signatures
On behalf of Ayer Capital Management, LP, Jay Venkatesan, 5/31/2012
** Signature of Reporting Person Date

On behalf of Ayer Capital Partners, LLC, Jay Venkatesan, General Partner 5/31/2012
** Signature of Reporting Person Date

On behalf of ACM Capital Partners LLC, Jay Venkatesan, Managing Member 5/31/2012
** Signature of Reporting Person Date

Jay Venkatesan 5/31/2012
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.