poorgradstudent
18 years ago
Pending Anormed purchase:
Millennium Agrees to Acquire AnorMED, Adding Phase III Oncology Product with Planned Near Term Launch Date
Tuesday September 26, 9:46 am ET
Phase III MOZOBIL complements Millennium's market-leading VELCADE and enhances patient eligibility for potentially life-saving stem cell transplants
CAMBRIDGE, Mass., Sept. 26 /PRNewswire-FirstCall/ -- Millennium Pharmaceuticals, Inc. (Nasdaq: MLNM - News) today announced it has entered into an agreement to acquire AnorMED, Inc. (Nasdaq: ANOR - News; TSX: AOM - News), a Canadian-based biopharmaceutical company with a late-stage Phase III hematology-oncology product, MOZOBIL. Under the terms of the agreement approved by the boards of directors of both companies and the largest shareholder of AnorMED, Millennium will commence within ten days a cash tender offer to acquire the shares of AnorMED stock at a price of U.S. $12.00 per outstanding share, for a total purchase price of approximately $515 million. This represents approximately a 21 percent premium over the closing price of AnorMED's shares on September 25, 2006.
MOZOBIL, currently in late-stage Phase III clinical development, is anticipated to be launched in the U.S. in 2008 subject to successful completion of clinical trials and regulatory approval. MOZOBIL, a small molecule CXCR4 chemokine antagonist, works by releasing stem cells from the bone marrow into circulation, improving the ability to collect the stem cells for transplant. Stem-cell transplants offer a potential cure for patients with certain hematological malignancies. Currently, a majority of the 50,000 to 60,000 transplant-eligible patients worldwide are unable to optimize the benefit of transplant due to sub-optimal stem-cell collection.
Assuming the acquisition is completed and MOZOBIL is approved, the product would be sold by Millennium's oncology sales force, which currently details VELCADE® (bortezomib) for Injection, the market leader in relapsed multiple myeloma.
"MOZOBIL is an excellent strategic fit with Millennium's focus in hematology-oncology, where our product VELCADE leads the market in treating patients with relapsed multiple myeloma," said Deborah Dunsire, M.D., President and Chief Executive Officer, Millennium. "This proposed acquisition is aligned with our goal to bring in products that accelerate revenue growth, leverage our oncology sales infrastructure and benefit from our development, regulatory and commercial expertise. We are extremely excited to carry forward the innovative work of the AnorMED team and to improve outcomes for transplant-eligible patients by bringing MOZOBIL to market."
Strong Clinical Progress for MOZOBIL
In the September 2005 issue of Blood, Neal Flomenberg, M.D., et al., reported that in a Phase II clinical trial, 60 percent of patients who received MOZOBIL in combination with the current standard of care for stem-cell mobilization, granulocyte-colony stimulating factor (G-CSF), collected the optimal target number of cells for transplant in two apheresis days, compared to only 16 percent of patients who received G-CSF alone. The cell yield in patients on MOZOBIL in combination with G-CSF was on average 290 percent higher compared to the cell yield in patients on G-CSF alone. The two ongoing randomized, double-blinded Phase III trials, designed under the special protocol assessment process with the Food and Drug Administration (FDA), are exploring MOZOBIL with G-CSF compared to placebo with G-CSF in multiple myeloma and non-Hodgkin's lymphoma (NHL) patients. Patient enrollment was completed in the Phase III multiple myeloma trial in July 2006 and, as of September 15, 2006, 92 percent of patients in the Phase III NHL trial had been enrolled with total enrollment expected to be completed by the end of 2006. Data from these registration-enabling trials are expected in 2007.
Based on preclinical data, MOZOBIL may also render patients with certain hematological diseases more responsive to chemotherapy, including patients with acute myelogenous leukemia (AML) and chronic lymphocytic leukemia (CLL).
Post-Acquisition Integration
If this transaction is completed, Millennium believes AnorMED would strengthen Millennium's foundation in building a leading biopharmaceutical company in oncology and inflammation. The assets of the combined companies would consist of:
* VELCADE - A first-in-class, market-leading product which provides an
unmatched survival advantage to relapsed multiple myeloma patients.
Millennium was recently granted priority review with a PDUFA date of
December 9, 2006 by the FDA for its supplementary new drug application
covering VELCADE for relapsed mantle cell lymphoma. Phase III trials
are ongoing in newly diagnosed multiple myeloma patients and relapsed
follicular and marginal zone lymphoma patients. Over 300 trials are
ongoing or planned to explore the potential of VELCADE in other cancers.
* MOZOBIL - A first-in-class, late-stage Phase III molecule for stem-cell
transplant in multiple myeloma and NHL with a planned U.S. launch in
2008. MOZOBIL has additional potential in chemosensitization for
hematological diseases including AML and CLL.
* Novel development pipeline - A pipeline of nine oncology and
inflammation molecules in clinical development and late-stage
preclinical development, in addition to VELCADE and MOZOBIL.
* Innovative discovery organization - An oncology-focused discovery
organization with expertise in protein homeostasis, signal transduction
and cell-surface targets. In the past three years, six Millennium
discovered molecules have progressed to the development pipeline.
* Collaborations - Millennium is engaged in several strategic alliances
which provide significant revenues to Millennium through royalties on
product sales, milestone payments and reimbursements. Alliances
include an ex-U.S. commercialization and global development agreement
with Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
(J&JPRD) for VELCADE, a development and commercialization agreement
with sanofi-aventis for anti-inflammatory small molecules and a
royalty-based agreement with Schering-Plough Corporation for the
marketed-product INTEGRILIN® (eptifibatide) Injection.
* Post-acquisition integration plans are underway and will be announced at
the closing of the transaction. The focus of the integration is to
accelerate filing and launch of MOZOBIL. The transaction is expected
to be modestly accretive to Millennium in 2008 and significantly
accretive in 2009 and beyond assuming successful commercial launch of
MOZOBIL in 2008.
Transaction Summary
Millennium's acquisition of AnorMED would take the form of an all cash tender offer to acquire all of AnorMED's outstanding shares at the price of U.S. $12.00 per share for a total amount of approximately U.S. $515 million. Millennium's tender offer will commence within 10 days and is expected to be open for at least 35 days. The boards of directors of both companies have approved the transaction. Several investment partnerships managed by Baker Brothers Advisors, L.L.C. and its affiliates have also entered into an agreement to tender their shares under the bid. Previously, AnorMED rejected an unsolicited offer by Genzyme Corporation, announced September 1, 2006, at U.S. $8.55 per share. In the event that the transaction between Millennium and AnorMED does not close successfully, Millennium would under certain circumstances be entitled to a termination fee of $19.5 million.
J.P. Morgan Securities Inc. acted as Millennium's financial advisor and provided a fairness opinion to Millennium's board of directors. Morgan Stanley also provided advisory services to Millennium on this transaction.
Conference Call Announcement
In conjunction with this news release, Millennium will host a live webcast of a conference call today, September 26, 2006 at 11:30 A.M. ET. This webcast can be accessed by visiting the Investors section of the Company's website, www.millennium.com. Following the webcast and following the posting of the transcript from the conference call on the Millennium website, an archived version of the call will be available at the same address for 30 days.
Ruellit
23 years ago
THE BULL MARKET BIOTECH INVESTOR for Wednesday, July 11, 2001
From the Hot Biotech board!
http://www.investorshub.com/boards/board.asp?board_id=561
The Bull Market Biotech Investor - http://www.BullMarket.com
THE BULL MARKET BIOTECH INVESTOR for Wednesday, July 11, 2001
Volume 20, #1
http://www.BullMarket.com
The Bull Market Biotech Investor is a bi-weekly series of discussions of the changing Biotech and Pharmaceutical world we live in and the companies that are going to profit from these changes.
The Bull Market Report web site has links to The Bull Market Biotech Investor (http://www.BullMarket.com). The site includes The Bull Market Biotech Portfolio (with 12-month price targets for our 19 stocks), and all issues of The Bull Market Biotech Investor, including today's. Descriptions of the companies and links to their web sites accompany the Portfolio. We cover the most relevant news relating to investment potential in the
healthcare industry, and particularly to the companies in our
Portfolio. Just because we haven't mentioned an event or a company doesn't mean we don't think it's important!
(Note: All prices below are current as of Wednesday's close, with percentage changes from last Wednesday.)
IN THIS ISSUE
1. COMMENTARY
2. NEWS IN THE BIOTECH SECTOR
3. BEST PERFORMERS IN 2Q
4. PORTFOLIO-SPECIFIC NEWS
5. PORTFOLIO TRACKER
=========================================
1. COMMENTARY
U.S. stocks have been showing a bit of strength during early morning trading sessions, but have not been able to hold those gains late in the day. The practice of “buy on the dips” has turned into a “wait and see” approach. This week, stocks have fallen to new three-month lows, as investors have grown concerned over upcoming quarterly earnings. As the earnings season begins, investors are preparing for a few hundred
financial reports this week and well over one-thousand next week. Several months ago, many investors, analysts and high-tech corporate executives were predicting that the economic downturn would end in the second half of this year. However, that no longer seems to be the case, as many firms have offered multiple revisions to future earnings and business forecasts.
Based on the data we’ve seen so far, it looks as though conditions apparently will not improve this year. The Biotech sector has taken its own hits the past few weeks.
Equipment suppliers such as Applied Biosystems (ABI, $23, down 12%), Waters Corp. (WAT, $24, down 10%) and Affymetrix (AFFX, $19, down 11%) have warned of declining sales and earnings going forward. In addition, Amgen (AMGN,
$57, down 6%) and Genentech (DNA, $43, down 26%) have both come up short in satisfying the FDA with drug applications and clinical data. The FDA recently judged as inadequate Amgen and Praecis Pharmaceuticals’ (PRCS, $12, down 14%) drug application for Plenaxis (to treat prostate cancer). Also, the FDA delayed approval for Genentech’s Xolair, an antibody to treat asthma and allergy.
Fortunately, not all of the news from the FDA has been bad. On Tuesday, Scios (SCIO, $21, down 4%) received an approval
letter from the FDA for the company’s Natrecor drug, which treats
congestive heart failure. Details with respect to drug labeling and approval of the manufacturing facility still need to be completed, but it appears as though Scios is now on its way to marketing a significant drug.
One group that is expected to provide consistent earnings growth is the large drug firms, including the generic drug manufacturers. The world’s largest drug maker, Pfizer (PFE, $39, down 4%), is expected to show 25% earnings per share growth over last year. Earnings are being driven by sales of its cholesterol drug Lipitor and cost savings associated with
the Warner-Lambert merger. Pfizer was downgraded on Wednesday after one analyst noted a recent decline in prescriptions for Pfizer’s drugs Zoloft, Norvasc and Lipitor. However, any weakness in sales seems to be pretty much priced into the stock.
Eli Lilly (LLY, $76, down 1%) is also expected to grow its earnings by 20% this quarter. However, Lilly faces the expiration of its patent in August on the antidepressant Prozac. Thus, its earnings are projected to decline
over the next four quarters. The decline in Prozac sales will
hopefully be offset by Xigris (formerly Zovant), Lilly’s anti-sepsis drug that the FDA is currently reviewing.
One company that is slated to sell its generic version of Prozac is Barr Laboratories (BRL, $66, down 6%). Barr announced on Wednesday that despite slowing sales of Tamoxifen (to treat breast cancer), improving sales among its other products will allow the company to beat earnings estimates by approximately 13%.
Other generic drug firms such as Taro Pharmaceuticals (TARO, $83, unch), Teva Pharmaceuticals (TEVA, $62, unch) and Ivax Corp. (IVX, $37, unch) have also been demonstrating solid
sales and earnings growth.
Late Wednesday, Genentech reported quarterly earnings that matched analysts’ estimates of 19 cents per share. Yet while the company recognized very solid annual growth in Rituxan and Herceptin sales, the sales figures came in about $10 million shy of expectations. Rituxan sales grew 83% to $188 million and Herceptin sales improved to $79 million. Genentech shares further declined about 5% during after-hours trading.
On a related note, IDEC Pharmaceuticals (IDPH, $61, down 10%)
stated that its quarterly earnings would come in at 15 cents, in-line with estimates. Unfortunately, in these market conditions, meeting estimates is not good enough for high PE stocks, and IDEC shares were trading down to $48 in the after-hours session.
Presented below are some of the companies (and their earnings
estimates) that are expected to release earnings in the coming week:
Thurs. 7/12
Abbott Labs ABT 0.45
Mon. 7/16
Diversa DVSA -0.11
Tues. 7/17
ArQule ARQL -0.16
Biogen BGEN 0.46
COR Therap CORR 0.05
Forest Labs FRX 0.36
Pfizer PFE 0.29
Wed. 7/18
Immunex IMNX 0.06
Millennium Ph MLNM -0.16
Thurs. 7/19
Dyax Corp. DYAX -0.23
Genzyme GENZ 0.28
Eli Lilly LLY 0.74
IDEC Pharma IDPH 0.15
Incyte Genom INCY -0.21
Molecular Dev MDCC 0.15
Rosetta Inph RSTA –0.31
=========================================
=========================================
2. NEWS IN THE BIOTECH SECTOR
Scios (SCIO, $21, down 4%) announced that it has received a letter from the U.S. FDA stating that the company’s New Drug Application for Natrecor is approvable. To finalize the approval process, Scios and the FDA need to define the labeling for Natrecor and complete a pre-approval inspection. Scios has developed Natrecor as an intravenous treatment for patients with acutely decompensated congestive heart failure (CHF). The company expects to launch the drug in the third quarter of this year.
Natrecor is a recombinant form of B-type natriuretic peptide -- a
naturally occurring hormone in the body that aids in the healthy
functioning of the heart. When approved by the FDA, Natrecor will become the first new treatment for acutely decompensated CHF in more than a decade. Roughly five million Americans suffer from heart failure, with 550,000 new cases diagnosed each year. There are approximately one million hospitalizations each year in the United States due to acute CHF.
For the second time in four months, Applied Biosystems (ABI, $23, down 12%) has warned of slowing revenue growth. The company, which makes genetic research equipment, projected a 12% decline in sales of its instruments. Applied Biosystems said it expects to post revenues for the fourth quarter ended June 30 of about $405 million, or below the $430 million projected by analysts. In March, Applied Biosystems projected revenue growth between 10-13% over the next few quarters, well below its
long-term growth target of 20%.
Barr Laboratories (BRL, $66, down 6%) raised its fiscal fourth-quarter earnings forecast to 49-50 cents from 43 cents. The company stated that sluggish sales of breast cancer drug Tamoxifen were more than offset by sales of other high-margin products. Barr, which specializes in the marketing of generic forms of brand-name drugs, particularly women's health-care products, had reported lower-than-expected fiscal third-quarter sales of Tamoxifen. Yet with sales of $90 million in the
quarter ended March 31, the drug still accounted for about 65% of the firm’s total revenues. However, Barr beat analysts’ estimates on sales of other drugs, such as clot buster Warfarin. The company is expected to enhance earnings later this year when it begins marketing a generic form of Eli Lilly’s (LLY, $76, down 1%) antidepressant, Prozac.
DeCODE Genetics (DCGN, $8, down 17%) extended its diagnostic collaboration with Swiss healthcare group Roche Holding in a deal that may be worth as much as $300 million. The five-year agreement, which covers the development and marketing of DNA-based diagnostic tests for major diseases, was first announced in March, but financial details were only
revealed after the two firms signed a number of definitive terms last week. The agreement extends an earlier collaboration between the two firms, worth up to $200 million, to develop new drugs using deCODE's genomic technologies. DeCODE has so far delivered three drug targets for schizophrenia, stroke and narrowed arteries under that deal.
DeCODE is attempting to develop diagnostics and discover
disease-related genes by analyzing the genetic composition of Iceland’s population. Under the deal, deCODE will receive some $15 million a year in fixed funding, including an upfront fee of $5 million, plus a royalty on sales of products that eventually come to market. The first DNA diagnostic product is expected to be available by the end of next year.
Abgenix (ABGX, $34, down 22%) received a milestone payment from Amgen (AMGN, $57, down 6%) due to the advancement into clinical trials of a fully human antibody therapeutic made with Abgenix’ technology. In April 1999, Amgen and Abgenix established a five-year collaboration to develop monoclonal antibodies against undisclosed antigen targets, which were
supplied by Amgen. Under the terms of that deal, Abgenix not only receives upfront research payments, but could also receive license fees, milestone payments and royalties on any future product sales by Amgen. Amgen is responsible for product development, manufacturing and marketing of any products developed through the collaboration.
Sequenom (SQNM, $12, down 1%) announced the sale of five MassArray systems, increasing the company's total number of system sales for the second quarter to nine. The MassArray system is used to analyze genes to determine their association to disease and to accelerate genetics-based diagnostics and drug development. Sequenom has identified 50 candidate disease genes and plans to enter into licensing deals and partnerships for
many of these genes. However, with the company’s pending acquisition of Gemini Genomics, Sequenom has positioned itself to internally develop some of the most interesting targets into marketable drugs.
=========================================
=========================================
3. BEST PERFORMERS IN 2Q
Although Biotech stocks have experienced a rough start in the
second-half of 2001, the Biotech sector was one of the best areas to be invested in the second quarter. During that time, the Amex Biotech index (BTK) advanced 30% while the Nasdaq Composite and S&P 500 index increased 17% and 6%, respectively. Of course, the Biotech sector began a steep
decline in early February that ended about March 22. Thus, Biotech stocks were deeply oversold to begin 2Q, and thus were primed to gain some ground.
Approximately one-third of Biotech stocks advanced 50% or more during 2Q, so it’s no wonder that these stocks have encountered some selling pressure in the past few weeks. Presented below are some of the best-performing stocks for the second quarter. For each security, we list last quarter’s closing price (Close), the point change (Chg.) and the percent change (%Chg.). Use the courier font to view the list.
Close Chg. %Chg.
StemCells STEM 5 3 170
Genome Therapeutic GENE 15 9 147
Dendreon DNDN 17 10 141
XOMA Ltd. XOMA 17 10 137
Genta GNTA 13 7 125
Immunomedics IMMU 21 12 122
Exelixis EXEL 19 10 118
Dyax Corp. DYAX 17 9 118
Enzo Biochem ENZ 34 17 102
ILEX Oncology ILXO 30 15 96
Protein Design Lab PDLI 87 42 95
Lexicon Genetics LEXG 12 6 90
Abgenix ABGX 45 21 90
=========================================
=========================================
4. PORTFOLIO-SPECIFIC NEWS
AMGEN’S (AMGN, $57, down 6%) initial target of getting Aranesp approved in the first half of 2001 has now passed. U.S. regulators continue to review the drug application. According to the company, discussions persist with respect to the drug’s labeling, but there have not been any requests for additional clinical data. Aranesp is a longer-lasting version of Epogen,
which is used to treat anemia and has already been approved for use in the European Union and Australia.
For investors, the concern is that continued delays in the approval process will thwart the company’s earnings growth. Last April, Amgen lowered its earnings growth projections for 2001 to the low-double-digit range due to a slower-than-expected regulatory review. The company currently markets Epogen in the U.S. for the kidney dialysis market while Johnson & Johnson (JNJ, $53, up 5%) is licensed to conduct overseas sales, which it does under the brand name Procrit. Approval for Aranesp is
significant because Amgen has retained all marketing rights to the drug.
CELERA GENOMICS (CRA, $32, down 20%) registered the Netherlands Research Council for access to its gene database information. The Netherlands Organization for Scientific Research is the largest national sponsor of fundamental scientific research at thirteen Dutch universities and fifteen
other academic research institutes. The Celera Discovery System is an integrated, web-based platform that enables users to leverage Celera's computational tools, super-computing power, and genomic and biological data to advance the discovery process for researchers worldwide.
Celera also announced that it has formulated an agreement with the National Cancer Institute (NCI), of the National Institutes of Health (NIH), that allows NCI principal investigators to independently choose whether or not to register for Celera’s database information. Although this agreement will not bring a windfall of revenues to Celera, it validates the strength of Celera’s annotated database in comparison to the public database developed by the Human Genome Project and funded by the NIH.
Shares of GENENTECH (DNA, $43, down 26%) took a nosedive yesterday after the U.S. FDA delayed approval for the company's asthma drug Xolair. U.S. regulators have requested additional preclinical and clinical data analyses from Genentech, which will require the company to resubmit its drug application.
Approval for Xolair was expected to occur early next year, but now will likely be delayed until 2003. Genentech is co-developing the drug with Novartis (NVS, $33, down 1%) and Tanox (TNOX, $14, down 52%), the drug's creator. Tanox shares dropped 44% yesterday on the news. Novartis and Genentech tested 1,950 patients in its Phase III trials, yet the FDA is concerned that not enough patients were tested. Therefore, they cannot determine whether or not the drug is safe based on the limited
clinical data that it currently has. It is unclear whether or not the FDA will require additional clinical trials. However, the good news is that the companies have a stable of data from both ongoing and completed trials that has not yet been submitted. For investors, the big concern here is the impact that Xolair's delay will have on Genentech's earnings growth
rate. The company is scheduled to release its quarterly earnings report tomorrow after the market closes, so we should learn a little bit more at that time.
PsychoGenics, a Biotechnology company engaged in neurological and behavioral research, initiated an agreement with GENE LOGIC (GLGC, $18, down 12%) to receive customized gene expression information relevant to central nervous system tissue samples.
For the past several years, HUMAN GENOME SCIENCES (HGSI, $48, down 16%) has participated in a drug discovery collaboration by providing access to its genetic database to a group of five large Pharmaceutical firms, including GlaxoSmithKline (GSK, $56, unch), Takeda, Merck KGaA, Sanofi-Synthelabo and Schering-Plough (SGP, $36, unch). The initial research term for the collaboration expired at the end of June, leaving Human Genome free to establish new drug discovery agreements with more
favorable revenue retention and profit-sharing terms. Those firms that participated in the consortium will be able to pursue the projects they have initiated, but will not be able to begin any new projects using Human Genome’s technology.
Human Genome’s management affirmed that only a small portion of the 90,000 human genes that the company has identified have been pursued by consortium members. Collectively, the members are actively pursuing approximately 430 research projects involving roughly 280 different genes for the creation of small molecule and antibody drugs. If any of these programs result in commercialized drugs, Human Genome will be entitled to certain milestone and royalty payments. In addition, for drugs developed
by GlaxoSmithKline, Human Genome will be entitled to certain
co-promotion rights.
There has been some debate as to the productivity of the human gene therapeutic consortium and the value of Human Genome’s genetic database. Some analysts expected the consortium to pursue many more gene targets (about 500) and also wondered why more drug candidates had not been moved into clinical trials. To date, only GlaxoSmithKline, the company's oldest partner, has pushed a drug candidate from the database into early human
testing. However, the number of gene targets that are being pursued is not so important as long as the quality of those targets is high. If the firms participating in the consortium have gone to great lengths to characterize their chosen genes and the proteins they make, then it makes sense that these companies have focused on fewer genes with better prospects for succeeding in clinical trials.
IMCLONE SYSTEMS (IMCL, $43, down 16%) filed an application with the FDA to market IMC-C225 in combination with irinotecan (a chemotherapeutic agent) to treat refractory colorectal cancers that over express the epidermal growth factor receptor (EGFR). IMC-C225 is a monoclonal antibody that binds to and blocks the activity of EGFRs, which are expressed on the surface of many cancer cell types. Early this year, the FDA designated IMC-C225 with the “fast track” status for the treatment of irinotecan-refractory colorectal cancer. Fast Track designation means that the FDA will facilitate the development and expedite the review of a drug if it is intended for the treatment of a serious or life-threatening condition, and it demonstrates the potential to address unmet medical
needs for such a condition.
ImClone Systems is studying IMC-C225 in a series of Phase II and Phase III clinical trials. The company is conducting Phase II clinical studies of IMC-C225 in combination with standard therapies in patients with various stages of colorectal cancer, pancreatic cancer, head and neck cancer, and non-small cell lung cancer. In addition to the Phase II studies, the Company is conducting a Phase III clinical trial combining IMC-C225 with
chemotherapy and another study combining IMC-C225 with radiotherapy as first-line treatments for head and neck cancer.
In an action that may squeeze the breath out of The Immune Response Corp. (IMNR, $2, down 52%), PFIZER (PFE, $39, down 4%) terminated its support to further develop Remune, an experimental anti-AIDS drug being developed by Immune Response. Shares of Immune Response declined 44% on the news to close at $2.58. Pfizer dropped the drug following disappointing clinical
trial results.
Pfizer became involved with Remune through Agouron Pharmaceuticals, which established a collaboration with Immune Response. Warner-Lambert acquired Agouron Pharmaceuticals and Pfizer later acquired Warner-Lambert. Immune Response holds enough cash to operate for the remainder of this year, but
decided several months ago to stop research efforts in other areas and focus exclusively on Remune.
VIROPHARMA (VPHM, $26, down 17%) filed plans with the Securities and Exchange Commission to periodically sell up to $300 million of its common and preferred stock, debt securities and warrants. The company stated in the filing that net proceeds will be added to its general funds for general corporate purposes, which may include: marketing and research
for its drug Picovir (for the treatment of viral respiratory infection, or the common cold) and research for its hepatitis C and RSV disease product candidates, potential acquisitions, capital expenditures, debt retirement and general working capital.
=========================================
=========================================
5. PORTFOLIO TRACKER
THE BULL MARKET BIOTECH INVESTOR PORTFOLIO
The columns indicate the closing price of stocks on July 11th, the percent change over the past five trading sessions (%Chg.) and the year-to-date percent change (%YTD). The table should be viewed with the courier font.
Close %Chg %YTD
Affymetrix AFFX 19 -11 -74
Amgen AMGN 57 -6 -11
Biomira BIOM 7 -2 26
Celera Genomics CRA 32 -20 -12
COR Therapeutics CORR 28 -8 -19
Gene Logic GLGC 18 -12 -1
Genentech DNA 43 -26 -48
Gilead Sciences GILD 53 -9 28
Human Genome Sciences HGSI 48 -16 6
ImClone Systems IMCL 43 -16 -3
ImmunoGen IMGN 15 -22 -18
Maxygen MAXY 17 -11 -31
Medarex MEDX 20 -17 -10
MedImmune MEDI 43 -8 -10
Millennium Phrmaceutcl MLNM 29 -15 -53
Merck MRK 62 -4 -33
Pfizer PFE 39 -4 -15
Pharmaceutical HOLDR PPH 96 -1 -16
ViroPharma VPHM 26 -17 79
Average Portfolio Return -7 -20
The S&P 500 -4 -11
The Nasdaq Composite -8 -20
The Amex Biotech Index -13 -17
Biotech HOLDRS -12 -31
Robert Mendoza, Ph.D.
Editor
The Bull Market Biotech Investor
Mendoza@BullMarket.com
Good Biotech investing!
Todd Shaver
Editor in Chief
The Bull Market Report
Washington, DC USA
muel <g>
News
Market Data
Register for streaming realtime charts, analysis tools, and prices.
Ask ADVFN Intelligence (AI)
