Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* Neri Antonio F	2. Issuer Name and Ticker or Trading Symbol Hewlett Packard Enterprise Co [ HPE ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President and CEO
(Last) (First) (Middle) C/O HEWLETT PACKARD ENTERPRISE COMPANY, 11445 COMPAQ CENTER DRIVE WEST	3. Date of Earliest Transaction (MM/DD/YYYY) 12/9/2021
(Street) HOUSTON, TX 77070 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	12/9/2021		A		206123 ⁽¹⁾	A	$15.38	600163	D
Common Stock	12/9/2021		F		93938	D	$15.38	506225	D
Common Stock	12/9/2021		A		146449 ⁽²⁾	A	$15.38	652674	D
Common Stock	12/9/2021		F		65363	D	$15.38	587311	D
Common Stock	12/10/2021		M		116106	A	$15.21	703417	D
Common Stock	12/10/2021		F		53495	D	$15.21	649922	D
Common Stock	12/10/2021		M		12720	A	$15.21	662642	D
Common Stock	12/10/2021		F		5861	D	$15.21	656781	D
Common Stock	12/10/2021		M		113110	A	$15.21	769891	D
Common Stock	12/10/2021		F		50140	D	$15.21	719751	D
Common Stock	12/10/2021		M		8931	A	$15.21	728682	D
Common Stock	12/10/2021		F		3959	D	$15.21	724723	D
Common Stock	12/10/2021		M		171892	A	$15.21	896615	D
Common Stock	12/10/2021		F		67640	D	$15.21	828975	D
Common Stock	12/10/2021		M		5842	A	$15.21	834817	D
Common Stock	12/10/2021		F		2299	D	$15.21	832518	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Restricted Stock Units	⁽³⁾	12/10/2021		M			116106 ⁽⁴⁾	⁽⁴⁾	⁽⁴⁾	Common Stock	116106	⁽⁴⁾	0	D
Restricted Stock Units	⁽³⁾	12/10/2021		M			113110 ⁽⁵⁾	⁽⁵⁾	⁽⁵⁾	Common Stock	113110	⁽⁵⁾	122040	D
Restricted Stock Units	⁽³⁾	12/10/2021		M			171892 ⁽⁶⁾	⁽⁶⁾	⁽⁶⁾	Common Stock	171892	⁽⁶⁾	355467	D
Restricted Stock Units	⁽³⁾	12/9/2021		A		422627 ⁽⁷⁾		⁽⁷⁾	⁽⁷⁾	Common Stock	422627	⁽⁷⁾	422627	D

Explanation of Responses:
(1)	As previously reported, on 12/10/18 the reporting person was granted performance adjusted restricted stock units ("PARSUs") subject to Non-GAAP Net Income and relative total stockholder return conditions being met at the time of vesting. These PARSUs vest 50% after 2 and 3 years subject to performance and are issued in Issuer's common stock.
(2)	On 12/10/19 the reporting person was granted PARSUs subject to Non-GAAP Net Income and relative total stockholder return conditions being met at the time of vesting. These PARSUs vest 50% after 2 and 3 years subject to performance and are issued in Issuer's common stock.
(3)	Each restricted stock unit represents a contingent right to receive one share of Issuer's common stock.
(4)	As previously reported, on 12/10/18 the reporting person was granted 348,318 Restricted Stock Units ("RSUs"), 116,106 of which vested on each of 12/10/19 and 12/10/20, and 116,106 of which vested on 12/10/21. Dividend equivalent rights accrue with respect to these RSUs when and as dividends are paid on Issuer's common stock. The number of derivative securities in column 5 also includes 12,720 vested RSU dividend equivalent rights and a de minimus adjustment of 0.4960 due to fractional rounding of the dividend.
(5)	As previously reported, on 12/10/19 the reporting person was granted 339,331 RSUs, 113,110 of which vested on 12/10/20, 113,110 of which vested on 12/10/21, and 113,111 of which will vest on 12/10/22. Dividend equivalent rights accrue with respect to these RSUs when and as dividends are paid on Issuer's common stock. The number of derivative securities in column 5 also includes 8,931 vested RSU dividend equivalent rights and a de minimus adjustment of 0.5778 due to fractional rounding of the dividend.
(6)	As previously reported, on 12/10/20 the reporting person was granted 515,677 RSUs, 171,892 of which vested on 12/10/21, 171,892 of which will vest on 12/10/22, and 171,893 of which will vest on 12/10/23. Dividend equivalent rights accrue with respect to these RSUs when and as dividends are paid on Issuer's common stock. The number of derivative securities in column 5 also includes 5,842 vested RSU dividend equivalent rights and a de minimus adjustment of 0.3094 due to fractional rounding of the dividend.
(7)	On 12/09/21 the reporting person was granted 422,627 RSUs, 140,875 of which will vest on 12/09/22, and 140,876 of which will vest on each of 12/09/23 and 12/09/24. Dividend equivalent rights accrue with respect to these RSUs when and as dividends are paid on Issuer's common stock.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Neri Antonio F C/O HEWLETT PACKARD ENTERPRISE COMPANY 11445 COMPAQ CENTER DRIVE WEST HOUSTON, TX 77070			President and CEO