Novogen Cardiovascular Drug Enters Phase I Clinical Trial

SYDNEY, AUSTRALIA and NEW CANAAN, CT with or without stenting, or coronary artery bypass surgery.

The processes causing restenosis are complex, but occur as a direct result of vessel injury during the stenting procedure, local inflammation and remodelling, together with the same processes of atherosclerosis that caused the vessel to block initially. NV-27 has been demonstrated to inhibit those processes in vitro via a variety of mechanisms. Importantly, orally administered NV-27 has been extremely effective in protecting against restenosis following endothelial injury in animal studies. NV-27 therefore appears to be ideally suited as an orally delivered agent to reduce restenosis following coronary artery stenting.

About restenosis

The coronary arteries supply blood to the heart. Through a variety of mechanisms including aging, a diet high in fat, smoking and inadequate exercise, atherosclerosis causes these arteries to block, resulting in angina (heart pain) or more critically an acute myocardial infarction (heart attack).

These vessels can be unblocked by a process called angioplasty, where the vessel is reopened using a balloon inflated inside the artery. More commonly, a small metal scaffold called a stent can be inserted to hold the artery open for an extended period. Unfortunately, the vessel often blocks up again in a process called 'restenosis.'

Depending on the type of stent used, the type of lesion and whether or not the patient is a diabetic and/or a smoker, restenosis may occur in up to 50% of procedures. The stent then needs to be replaced with another. If the disease is very severe, a patient may undergo bypass surgery where the coronary arteries are replaced with veins from other parts of the body. Again, restenosis can occur, requiring the surgery to be repeated.

Though the addition of immunosuppressive or anti-proliferative agents such as coating on stents (so called drug-eluting stents) have reduced the occurrence of restenosis, it still remains a significant clinical problem, the results of which can be catastrophic.

About Novogen Limited:

Novogen Limited (ASX: NRT) (NASDAQ: NVGN) is an Australian biotechnology company that has patented isoflavone technology for the treatment and prevention of degenerative diseases and disorders. Over the past ten years, Novogen has conducted the largest and most comprehensive isoflavone clinical testing programs in the world. Novogen is involved in drug discovery and product development for disorders that are commonly associated with aging and coordinates an international clinical research and development program with external collaborators, hospitals and universities. For more information, visit www.novogen.com.

Under U.S. law, a new drug cannot be marketed until it has been investigated in clinical trials and approved by the FDA as being safe and effective for the intended use. Statements included in this press release that are not historical in nature are "forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. You should be aware that our actual results could differ materially from those contained in the forward-looking statements, which are based on management's current expectations and are subject to a number of risks and uncertainties, including, but not limited to, our failure to successfully commercialize our product candidates; costs and delays in the development and/or FDA approval, or the failure to obtain such approval, of our product candidates; uncertainties in clinical trial results; our inability to maintain or enter into, and the risks resulting from our dependence upon, collaboration or contractual arrangements necessary for the development, manufacture, commercialization, marketing, sales and distribution of any products; competitive factors; our inability to protect our patents or proprietary rights and obtain necessary rights to third party patents and intellectual property to operate our business; our inability to operate our business without infringing the patents and proprietary rights of others; general economic conditions; the failure of any products to gain market acceptance; our inability to obtain any additional required financing; technological changes; government regulation; changes in industry practice; and one-time events. We do not intend to update any of these factors or to publicly announce the results of any revisions to these forward-looking statements.

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For further information: Professor Alan Husband Research Director Novogen Limited TEL 011 2 9878 0088 http://www.novogen.com WHITECOAT STRATEGIES CONTACT: David Sheon TEL 202 470-2880

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