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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 10-Q
(Mark One)
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934.
For the quarterly period ended January 31, 2024
OR
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934.
For the transition period from to .
Commission File No. 001-36830
KALVISTA PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
|
|
|
Delaware |
|
20-0915291 |
(State or other jurisdiction of incorporation or organization) |
|
(I.R.S. Employer Identification No.) |
55 Cambridge Parkway Suite 901E Cambridge, Massachusetts |
|
02142 |
(Address of principal executive offices) |
|
(Zip Code) |
857-999-0075
(Registrant’s telephone number, including area code)
n/a
Former name, former address and former fiscal year, if changed since last report
Securities registered pursuant to Section 12(b) of the Exchange Act:
|
|
|
Title of each class |
Trading Symbol(s) |
Name of each exchange on which registered |
Common Stock, $0.001 par value per share |
KALV |
The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes NO
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes NO
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
|
|
|
|
|
|
|
Large accelerated filer |
|
Accelerated filer |
|
|
|
Non-accelerated filer |
|
Smaller reporting company |
|
|
|
|
|
Emerging growth company |
|
|
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). YES NO
As of March 8, 2024, the registrant had 42,188,296 shares of common stock, $0.001 par value per share, issued and outstanding.
Table of Contents
PART I. FINANCIAL INFORMATION
Item 1. FINANCIAL STATEMENTS
KalVista Pharmaceuticals, Inc.
Condensed Consolidated Balance Sheets
(in thousands, except share and per share amounts)
(Unaudited)
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
April 30, |
|
|
|
2024 |
|
|
2023 |
|
Assets |
|
|
|
|
|
|
Current assets: |
|
|
|
|
|
|
Cash and cash equivalents |
|
$ |
23,056 |
|
|
$ |
56,238 |
|
Marketable securities |
|
|
52,530 |
|
|
|
93,137 |
|
Research and development tax credit receivable |
|
|
23,011 |
|
|
|
16,568 |
|
Prepaid expenses and other current assets |
|
|
5,506 |
|
|
|
6,383 |
|
Total current assets |
|
|
104,103 |
|
|
|
172,326 |
|
Property and equipment, net |
|
|
2,423 |
|
|
|
2,948 |
|
Right of use assets |
|
|
7,045 |
|
|
|
7,822 |
|
Other assets |
|
|
397 |
|
|
|
106 |
|
Total assets |
|
$ |
113,968 |
|
|
$ |
183,202 |
|
Liabilities and stockholders’ equity |
|
|
|
|
|
|
Current liabilities: |
|
|
|
|
|
|
Accounts payable |
|
$ |
3,101 |
|
|
$ |
4,817 |
|
Accrued expenses |
|
|
14,840 |
|
|
|
9,128 |
|
Lease liability - current portion |
|
|
1,187 |
|
|
|
1,087 |
|
Total current liabilities |
|
|
19,128 |
|
|
|
15,032 |
|
Long-term liabilities: |
|
|
|
|
|
|
Lease liability - net of current portion |
|
|
6,257 |
|
|
|
7,145 |
|
Total long-term liabilities |
|
|
6,257 |
|
|
|
7,145 |
|
Commitments and contingencies (Note 6) |
|
|
|
|
|
|
Stockholders’ equity |
|
|
|
|
|
|
Common stock, $0.001 par value, 100,000,000 authorized |
|
|
|
|
|
|
Shares issued and outstanding: 34,595,623 at January 31, 2024 and 34,171,138 at April 30, 2023 |
|
|
34 |
|
|
|
34 |
|
Additional paid-in capital |
|
|
516,920 |
|
|
|
507,133 |
|
Accumulated deficit |
|
|
(425,077 |
) |
|
|
(343,082 |
) |
Accumulated other comprehensive loss |
|
|
(3,294 |
) |
|
|
(3,060 |
) |
Total stockholders’ equity |
|
|
88,583 |
|
|
|
161,025 |
|
Total liabilities and stockholders’ equity |
|
$ |
113,968 |
|
|
$ |
183,202 |
|
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.
KalVista Pharmaceuticals, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share amounts)
(Unaudited)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended |
|
|
Nine Months Ended |
|
|
|
January 31, |
|
|
January 31, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Revenue |
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
|
|
|
Research and development |
|
|
22,523 |
|
|
|
20,063 |
|
|
|
60,919 |
|
|
|
56,325 |
|
General and administrative |
|
|
10,628 |
|
|
|
6,882 |
|
|
|
31,071 |
|
|
|
22,818 |
|
Total operating expenses |
|
|
33,151 |
|
|
|
26,945 |
|
|
|
91,990 |
|
|
|
79,143 |
|
Operating loss |
|
|
(33,151 |
) |
|
|
(26,945 |
) |
|
|
(91,990 |
) |
|
|
(79,143 |
) |
Other income: |
|
|
|
|
|
|
|
|
|
|
|
|
Interest income |
|
|
684 |
|
|
|
732 |
|
|
|
2,383 |
|
|
|
1,424 |
|
Foreign currency exchange gain (loss) |
|
|
1,120 |
|
|
|
597 |
|
|
|
277 |
|
|
|
(237 |
) |
Other income |
|
|
2,319 |
|
|
|
4,313 |
|
|
|
7,335 |
|
|
|
11,354 |
|
Total other income |
|
|
4,123 |
|
|
|
5,642 |
|
|
|
9,995 |
|
|
|
12,541 |
|
Net loss |
|
$ |
(29,028 |
) |
|
$ |
(21,303 |
) |
|
$ |
(81,995 |
) |
|
$ |
(66,602 |
) |
Other comprehensive (loss) income: |
|
|
|
|
|
|
|
|
|
|
|
|
Foreign currency translation (loss) gain |
|
|
(46 |
) |
|
|
1,128 |
|
|
|
(373 |
) |
|
|
(573 |
) |
Unrealized holding gain on marketable securities |
|
|
438 |
|
|
|
658 |
|
|
|
1,270 |
|
|
|
808 |
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
|
|
(221 |
) |
|
|
(1 |
) |
|
|
(1,130 |
) |
|
|
84 |
|
Other comprehensive gain (loss) |
|
|
171 |
|
|
|
1,785 |
|
|
|
(233 |
) |
|
|
319 |
|
Comprehensive loss |
|
$ |
(28,857 |
) |
|
$ |
(19,518 |
) |
|
$ |
(82,228 |
) |
|
$ |
(66,283 |
) |
Net loss per share to common stockholders, basic and diluted |
|
$ |
(0.84 |
) |
|
$ |
(0.75 |
) |
|
$ |
(2.37 |
) |
|
$ |
(2.58 |
) |
Weighted average common shares outstanding, basic and diluted |
|
|
34,723,379 |
|
|
|
28,278,453 |
|
|
|
34,567,853 |
|
|
|
25,810,369 |
|
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.
KalVista Pharmaceuticals, Inc.
Condensed Consolidated Statement of Changes in Stockholders’ Equity
(in thousands, except share amounts)
(Unaudited)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended January 31, 2024 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Accumulated |
|
|
|
|
|
|
|
|
|
|
|
Additional |
|
|
|
|
|
Other |
|
|
Total |
|
|
Common Stock |
|
|
Paid-in |
|
|
Accumulated |
|
|
Comprehensive |
|
|
Stockholders' |
|
|
Shares |
|
|
Amount |
|
|
Capital |
|
|
Deficit |
|
|
Loss |
|
|
Equity |
|
Balance at May 1, 2023 |
|
34,171,138 |
|
|
$ |
34 |
|
|
$ |
507,133 |
|
|
$ |
(343,082 |
) |
|
$ |
(3,060 |
) |
|
$ |
161,025 |
|
Issuance of common stock from equity incentive plans |
|
35,313 |
|
|
|
— |
|
|
|
204 |
|
|
|
— |
|
|
|
— |
|
|
|
204 |
|
Release of restricted stock units |
|
60,144 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
3,254 |
|
|
|
— |
|
|
|
— |
|
|
|
3,254 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(25,317 |
) |
|
|
— |
|
|
|
(25,317 |
) |
Foreign currency translation gain |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
91 |
|
|
|
91 |
|
Unrealized holding gain from marketable securities |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
392 |
|
|
|
392 |
|
Reclassification adjustment for realized gain on marketable securities included in net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(314 |
) |
|
|
(314 |
) |
Balance at July 31, 2023 |
|
34,266,595 |
|
|
$ |
34 |
|
|
$ |
510,591 |
|
|
$ |
(368,399 |
) |
|
$ |
(2,891 |
) |
|
$ |
139,335 |
|
Issuance of common stock from equity incentive plans |
|
18,000 |
|
|
|
— |
|
|
|
128 |
|
|
|
— |
|
|
|
— |
|
|
|
128 |
|
Release of restricted stock units |
|
136,863 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
3,207 |
|
|
|
— |
|
|
|
— |
|
|
|
3,207 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(27,650 |
) |
|
|
— |
|
|
|
(27,650 |
) |
Foreign currency translation loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(419 |
) |
|
|
(419 |
) |
Unrealized holding gain from marketable securities |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
440 |
|
|
|
440 |
|
Reclassification adjustment for realized gain on marketable securities included in net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(595 |
) |
|
|
(595 |
) |
Balance at October 31, 2023 |
|
34,421,458 |
|
|
$ |
34 |
|
|
$ |
513,926 |
|
|
$ |
(396,049 |
) |
|
$ |
(3,465 |
) |
|
$ |
114,446 |
|
Issuance of common stock from equity incentive plans |
|
36,914 |
|
|
|
— |
|
|
|
283 |
|
|
|
— |
|
|
|
— |
|
|
|
283 |
|
Release of restricted stock units |
|
137,251 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
2,711 |
|
|
|
— |
|
|
|
— |
|
|
|
2,711 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
|
|
|
(29,028 |
) |
|
|
|
|
|
(29,028 |
) |
Foreign currency translation loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(46 |
) |
|
|
(46 |
) |
Unrealized holding gain from marketable securities |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
438 |
|
|
|
438 |
|
Reclassification adjustment for realized gain on marketable securities included in net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(221 |
) |
|
|
(221 |
) |
Balance at January 31, 2024 |
|
34,595,623 |
|
|
$ |
34 |
|
|
$ |
516,920 |
|
|
$ |
(425,077 |
) |
|
$ |
(3,294 |
) |
|
$ |
88,583 |
|
KalVista Pharmaceuticals, Inc.
Condensed Consolidated Statement of Changes in Stockholders’ Equity
(in thousands, except share amounts)
(Unaudited)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended January 31, 2023 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Accumulated |
|
|
|
|
|
|
|
|
|
|
|
Additional |
|
|
|
|
|
Other |
|
|
Total |
|
|
Common Stock |
|
|
Paid-in |
|
|
Accumulated |
|
|
Comprehensive |
|
|
Stockholders' |
|
|
Shares |
|
|
Amount |
|
|
Capital |
|
|
Deficit |
|
|
Loss |
|
|
Equity |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at May 1, 2022 |
|
24,550,748 |
|
|
$ |
25 |
|
|
$ |
439,104 |
|
|
$ |
(250,175 |
) |
|
$ |
(3,861 |
) |
|
$ |
185,093 |
|
Issuance of common stock from equity incentive plans |
|
20,124 |
|
|
|
— |
|
|
|
168 |
|
|
|
— |
|
|
|
— |
|
|
|
168 |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
2,642 |
|
|
|
— |
|
|
|
— |
|
|
|
2,642 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(23,042 |
) |
|
|
— |
|
|
|
(23,042 |
) |
Foreign currency translation loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(403 |
) |
|
|
(403 |
) |
Unrealized holding gain from marketable securities |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
98 |
|
|
|
98 |
|
Reclassification adjustment for realized loss on marketable securities included in net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
16 |
|
|
|
16 |
|
Balance at July 31, 2022 |
|
24,570,872 |
|
|
$ |
25 |
|
|
$ |
441,914 |
|
|
$ |
(273,217 |
) |
|
$ |
(4,150 |
) |
|
$ |
164,572 |
|
Issuance of common stock from equity incentive plans |
|
31,151 |
|
|
|
— |
|
|
|
168 |
|
|
|
— |
|
|
|
— |
|
|
|
168 |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
2,506 |
|
|
|
— |
|
|
|
— |
|
|
|
2,506 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(22,257 |
) |
|
|
— |
|
|
|
(22,257 |
) |
Foreign currency translation loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(1,297 |
) |
|
|
(1,297 |
) |
Unrealized holding gain from marketable securities |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
52 |
|
|
|
52 |
|
Reclassification adjustment for realized loss on marketable securities included in net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
69 |
|
|
|
69 |
|
Balance at October 31, 2022 |
|
24,602,023 |
|
|
$ |
25 |
|
|
$ |
444,588 |
|
|
$ |
(295,474 |
) |
|
$ |
(5,326 |
) |
|
$ |
143,813 |
|
Issuance of common stock from equity incentive plans |
|
41,540 |
|
|
|
— |
|
|
|
146 |
|
|
|
— |
|
|
|
— |
|
|
|
146 |
|
Issuance of common stock, net of issuance costs of $0.3 million |
|
9,484,199 |
|
|
|
9 |
|
|
|
56,573 |
|
|
|
— |
|
|
|
— |
|
|
|
56,582 |
|
Issuance of pre-funded warrants for the purchase of common stock, net of issuance costs |
|
— |
|
|
|
— |
|
|
|
1,085 |
|
|
|
— |
|
|
|
— |
|
|
|
1,085 |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
2,333 |
|
|
|
— |
|
|
|
— |
|
|
|
2,333 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(21,303 |
) |
|
|
— |
|
|
|
(21,303 |
) |
Foreign currency translation gain |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
1,128 |
|
|
|
1,128 |
|
Unrealized holding gain from marketable securities |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
658 |
|
|
|
658 |
|
Reclassification adjustment for realized gain on marketable securities included in net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(1 |
) |
|
|
(1 |
) |
Balance at January 31, 2023 |
|
34,127,762 |
|
|
$ |
34 |
|
|
$ |
504,725 |
|
|
$ |
(316,777 |
) |
|
$ |
(3,541 |
) |
|
$ |
184,441 |
|
KalVista Pharmaceuticals, Inc.
Condensed Consolidated Statements of Cash Flows
(in thousands, unaudited)
|
|
|
|
|
|
|
|
|
Nine Months Ended |
|
|
January 31, |
|
|
2024 |
|
|
2023 |
|
Cash flows from operating activities |
|
|
|
|
|
Net loss |
$ |
(81,995 |
) |
|
$ |
(66,602 |
) |
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
|
Depreciation and amortization |
|
597 |
|
|
|
530 |
|
Stock-based compensation expense |
|
9,172 |
|
|
|
7,481 |
|
Realized (gain) loss from sale of marketable securities |
|
(1,130 |
) |
|
|
84 |
|
Non-cash operating lease expense |
|
(11 |
) |
|
|
52 |
|
Amortization of premium on marketable securities |
|
88 |
|
|
|
890 |
|
Foreign currency exchange loss (gain) |
|
596 |
|
|
|
(1,339 |
) |
Changes in operating assets and liabilities: |
|
|
|
|
|
Research and development tax credit receivable |
|
(6,215 |
) |
|
|
2,049 |
|
Prepaid expenses and other assets |
|
906 |
|
|
|
4,440 |
|
Accounts payable |
|
(1,778 |
) |
|
|
(1,911 |
) |
Accrued expenses |
|
5,644 |
|
|
|
1,701 |
|
Net cash used in operating activities |
|
(74,126 |
) |
|
|
(52,625 |
) |
Cash flows from investing activities |
|
|
|
|
|
Purchases of marketable securities |
|
(47,687 |
) |
|
|
(63,757 |
) |
Sales and maturities of marketable securities |
|
89,475 |
|
|
|
112,509 |
|
Acquisition of property and equipment |
|
(27 |
) |
|
|
(1,127 |
) |
Website development costs |
|
(294 |
) |
|
|
- |
|
Net cash provided by investing activities |
|
41,467 |
|
|
|
47,625 |
|
Cash flows from financing activities |
|
|
|
|
|
Issuance of common stock from equity incentive plans |
|
616 |
|
|
|
482 |
|
Issuance of common stock, net of offering expenses of $0.3 million |
|
- |
|
|
|
56,582 |
|
Issuance of pre-funded warrants, net of offering expenses |
|
- |
|
|
|
1,085 |
|
Net cash provided by financing activities |
|
616 |
|
|
|
58,149 |
|
Effect of exchange rate changes on cash and cash equivalents |
|
(1,139 |
) |
|
|
1,168 |
|
Net (decrease) increase in cash and cash equivalents |
|
(33,182 |
) |
|
|
54,317 |
|
Cash and cash equivalents at beginning of period |
|
56,238 |
|
|
|
30,732 |
|
Cash and cash equivalents at end of period |
$ |
23,056 |
|
|
$ |
85,049 |
|
Supplemental disclosures of non-cash activities: |
|
|
|
|
|
Right of use assets obtained in exchange for operating lease liabilities |
$ |
- |
|
|
$ |
1,192 |
|
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.
Notes to the Condensed Consolidated Financial Statements (unaudited)
Company Background
KalVista Pharmaceuticals, Inc. (“Company”) is a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors for diseases with significant unmet need. The Company applies its insights into the chemistry and biology of proteases to develop orally delivered, small molecule inhibitors with high selectivity, potency, and bioavailability that it believes will make them successful treatments for disease. The Company’s initial focus is on developing novel, oral therapeutics targeting hereditary angioedema (HAE).
In February 2024, the Company announced topline data from the Phase 3 KONFIDENT clinical trial evaluating the safety and efficacy of sebetralstat as the first potential oral, on-demand therapy for HAE. KONFIDENT was the largest and most representative trial ever conducted in HAE, enrolling a total of 136 patients from 66 clinical sites across 20 countries. Eligible participants included adolescents, patients using long-term prophylaxis, and the trial evaluated all attack severities and locations.
The clinical trial met all primary and key secondary endpoints and demonstrated a favorable safety profile. Primary and key secondary endpoints were analyzed in a fixed, hierarchical sequence and adjusted for multiplicity. HAE attacks treated with both 300 mg and 600 mg of sebetralstat achieved the primary endpoint of beginning of symptom relief significantly faster than placebo (p<0.0001 for 300 mg, p=0.0013 for 600 mg). The median time to beginning of symptom relief was 1.6 hours with sebetralstat 300 mg, 1.8 hours with sebetralstat 600 mg and 6.7 hours with placebo. Key secondary endpoints showed that attacks treated with sebetralstat 300 mg or 600 mg achieved a significantly faster time to reduction in attack severity from baseline, compared to placebo (p=0.0036 for 300 mg and p=0.0032 for 600 mg). Attacks treated with sebetralstat 300 mg or 600 mg demonstrated a significantly faster time to complete attack resolution, compared to placebo (p=0.0022 for 300 mg and p<0.0001 for 600 mg). The KONFIDENT trial had no patient withdrawals due to an adverse event and no treatment-related serious adverse events (SAEs). Consistent with previous studies, sebetralstat was well-tolerated, with a safety profile similar to placebo.
The Company anticipates submitting a New Drug Application (“NDA”) for sebetralstat to the FDA in the first half of 2024. The Company also expects to file for approval in the European Union (“E.U.”) and Japan later in 2024.
In addition, the Company is conducting preclinical development of novel, oral Factor XIIa (“Factor XIIa”) inhibitors, which the Company initially is advancing to provide a next generation of HAE therapeutics. Factor XIIa also offers the opportunity for future expansion into other high unmet need indications in therapeutic areas outside HAE.
The Company’s headquarters is located in Cambridge, Massachusetts, with additional offices located in Porton Down, United Kingdom, Salt Lake City, Utah, and Zug, Switzerland.
Liquidity
The Company has devoted substantially all of its efforts to research and development, including preclinical and clinical trials of sebetralstat. The Company has not completed the development of any product candidates or commenced commercial operations. Pharmaceutical drug product candidates, like those being developed by the Company, require approvals from the FDA or foreign regulatory agencies prior to commercial sales. There can be no assurance that any product candidates will receive the necessary approvals and any failure to receive approval or delay in approval may have a material adverse impact on the Company’s business and financial results. The Company is subject to a number of risks and uncertainties similar to those of other life science companies developing new products, including, among others, the risks related to the necessity to obtain adequate additional financing, to successfully develop product candidates, to obtain regulatory approval of product candidates, to comply with government regulations, to successfully commercialize its potential products, to the protection of proprietary technology and to the dependence on key individuals.
To date, the Company has not generated any product sales revenues and does not have any products that have been approved for commercialization. As of January 31, 2024, the Company had an accumulated deficit of $425.1 million and $75.6 million of cash, cash equivalents and marketable securities. The Company does not expect to generate significant revenue unless and until it obtains regulatory approval for, and commercializes, one of its current or future product candidates. The Company anticipates that it will continue to incur losses for the foreseeable future, and it expects those losses to increase as it continues the development of, and seeks regulatory approvals for, product candidates, and begins to commercialize any approved products. The Company is subject to all of the risks inherent in the development of new therapeutic products, and it may encounter unforeseen expenses, difficulties, complications, delays, and other unknown factors that may adversely affect its business.
On February 14, 2024, the Company entered into an underwriting agreement with Jefferies LLC, Leerink Partners LLC, Stifel, Nicolaus & Company, Incorporated, and Cantor Fitzgerald & Co., as the representatives of several underwriters to sell an aggregate of 7,016,312 shares of the Company’s common stock at price of $15.25 per share and pre-funded warrants to purchase up to 3,483,688 shares of common stock at a price of $15.249 per pre-funded warrant (the "Underwritten Offering"). The net proceeds from the Underwritten Offering, after deducting estimated expenses, were approximately $150.1 million.
The Company currently anticipates that, based upon its operating plans and existing capital resources, it has sufficient funding to operate for at least the next twelve months.
The Company will need to expend substantial resources for research and development, including costs associated with the clinical testing of its product candidates and will need to obtain additional financing to fund its operations and to conduct trials for its product candidates. The Company will seek to finance future cash needs through equity offerings, future grants, corporate partnerships, and product sales.
The Company has never been profitable and has incurred significant operating losses in each year since its inception. Cash requirements may vary materially from those now planned because of changes in the Company’s focus and direction of its research and development programs, competitive and technical advances, patent developments, regulatory changes, or other developments. Additional financing will be required to continue operations after the Company exhausts its current cash resources and to continue its long-term plans for clinical trials and new product development. There can be no assurance that any such financing can be obtained by the Company, or if obtained, what the terms thereof may be, or that any amount that the Company is able to raise will be adequate to support the Company's working capital requirements until it achieves profitable operations. If adequate additional working capital is not secured when needed, the Company may be required to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible and/or suspend or curtail planned research programs. Any of these actions could materially harm the Company’s business and prospects.
2.Summary of Significant Accounting Policies
Principles of Consolidation: The accompanying unaudited interim condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation.
The accompanying unaudited interim condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) for interim financial information and in accordance with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. Such financial statements reflect all adjustments that are, in management’s opinion, necessary to present fairly, in all material respects, the Company’s consolidated financial position, results of operations, and cash flows. The unaudited interim condensed consolidated financial statements have been prepared on the same basis as the annual financial statements. There were no adjustments other than normal recurring adjustments. These unaudited interim condensed consolidated financial results are not necessarily indicative of the results to be expected for the year ending April 30, 2024, or for any other future annual or interim period. The accompanying unaudited interim condensed consolidated financial statements should be read in conjunction with the audited financial statements as of and for the year ended April 30, 2023 in the Company’s Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”) on July 10, 2023.
Segment Reporting: The chief operating decision maker, the CEO, manages the Company’s operations as a single operating segment for the purposes of assessing performance and making operating decisions.
Recent Accounting Pronouncements: In June 2016, the FASB issued ASU 2016-13, Financial Instruments-Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments, which amends the impairment model by requiring entities to use a forward-looking approach on expected losses to estimate credit losses on certain financial instruments, including trade receivables and available-for-sale debt securities. This guidance became effective on May 1, 2023 and did not have a material impact to the consolidated financial statements. As the Company has never recorded any other-than-temporary-impairment adjustments to its available-for-sale debt securities prior to the effective date, no transition provisions were applicable to the Company.
Net Loss per Share: Basic net loss per share is computed by dividing the net loss by the weighted average number of common shares outstanding during the period. Diluted net loss per share is computed by dividing net loss by the sum of the weighted average number of common shares and the number of potential dilutive common share equivalents outstanding during the period. Potential dilutive common share equivalents consist of the incremental common shares issuable upon the exercise of share options and awards.
Potential dilutive common share equivalents consist of:
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
|
2024 |
|
|
2023 |
|
Stock options and awards |
|
|
6,229,313 |
|
|
|
5,386,625 |
|
The Company uses the treasury stock method to calculate the weighted average shares used in computing diluted net loss per share. In computing diluted earnings per share, common share equivalents are not considered in periods in which a net loss is reported, as the inclusion of the common share equivalents would be anti-dilutive. As a result, there is no difference between the Company’s basic and diluted loss per share for the periods presented.
The weighted average number of common shares used in the basic and diluted net loss per common share calculations includes the weighted-average pre-funded warrants outstanding during the period as they are exercisable at any time for nominal cash consideration.
Fair Value Measurement: The Company classifies fair value measurements using a three-level hierarchy that prioritizes the inputs used to measure fair value. This hierarchy requires entities to maximize the use of observable inputs and minimize the use of unobservable inputs. The three levels of inputs used to measure fair value are as follows: Level 1, quoted market prices in active markets for identical assets or liabilities; Level 2, observable inputs other than quoted market prices included in Level 1, such as quoted market prices for markets that are not active or other inputs that are observable or can be corroborated by observable market data; and Level 3, unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities, including certain pricing models, discounted cash flow methodologies and similar techniques that use significant unobservable inputs. These fair values are obtained from independent pricing services which utilize Level 1 and Level 2 inputs.
The following tables summarize the cash equivalents and marketable securities measured at fair value on a recurring basis as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
January 31, 2024 |
|
Cash equivalents |
$ |
57 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
57 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
Corporate debt securities |
|
— |
|
|
|
48,339 |
|
|
|
— |
|
|
|
48,339 |
|
U.S. government agency securities |
|
— |
|
|
|
4,191 |
|
|
|
— |
|
|
|
4,191 |
|
|
$ |
57 |
|
|
$ |
52,530 |
|
|
$ |
— |
|
|
$ |
52,587 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
April 30, 2023 |
|
Cash equivalents |
$ |
31,507 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
31,507 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
Corporate debt securities |
|
— |
|
|
|
77,967 |
|
|
|
— |
|
|
|
77,967 |
|
U.S. government agency securities |
|
— |
|
|
|
15,170 |
|
|
|
— |
|
|
|
15,170 |
|
|
$ |
31,507 |
|
|
$ |
93,137 |
|
|
$ |
— |
|
|
$ |
124,644 |
|
The objectives of the Company’s investment policy are to ensure the safety and preservation of invested funds, as well as to maintain liquidity sufficient to meet cash flow requirements. The Company invests its excess cash in securities issued by financial institutions, commercial companies, and government agencies that management believes to be of high credit quality in order to limit the amount of its credit exposure. The Company has not realized any material losses from its investments.
The Company classifies all of its debt securities as available-for-sale. Unrealized gains and losses on investments are recognized in accumulated comprehensive loss, unless an unrealized loss is considered to be other than temporary, in which case the unrealized loss is charged to operations. The Company periodically reviews its investments for other than temporary declines in fair value below cost basis and whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. The Company believes the individual unrealized losses represent temporary declines primarily resulting from interest rate changes. Realized gains and losses are included in other income in the consolidated statements of operations and comprehensive loss and are determined using the specific identification method with transactions recorded on a trade date basis.
The following tables summarize the fair values of the Company’s investments by type as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
January 31, 2024 |
|
|
Amortized |
|
|
Unrealized |
|
|
Unrealized |
|
|
Estimated |
|
|
Cost |
|
|
Gains |
|
|
Losses |
|
|
Fair Value |
|
Corporate debt securities |
$ |
47,827 |
|
|
$ |
525 |
|
|
$ |
(13 |
) |
|
$ |
48,339 |
|
Obligations of the U.S. Government and its agencies |
|
4,178 |
|
|
|
13 |
|
|
|
— |
|
|
|
4,191 |
|
Total |
$ |
52,005 |
|
|
$ |
538 |
|
|
$ |
(13 |
) |
|
$ |
52,530 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
April 30, 2023 |
|
|
Amortized |
|
|
Unrealized |
|
|
Unrealized |
|
|
Estimated |
|
|
Cost |
|
|
Gains |
|
|
Losses |
|
|
Fair Value |
|
Corporate debt securities |
$ |
77,768 |
|
|
$ |
367 |
|
|
$ |
(168 |
) |
|
$ |
77,967 |
|
Obligations of the U.S. Government and its agencies |
|
15,094 |
|
|
|
76 |
|
|
|
|
|
|
15,170 |
|
Total |
$ |
92,862 |
|
|
$ |
443 |
|
|
$ |
(168 |
) |
|
$ |
93,137 |
|
The Company has classified all of its available-for-sale investment securities, including those with maturities beyond one year, as current assets on its condensed consolidated balance sheets based on the highly liquid nature of the investment securities and because these investment securities are considered available for use in current operations.
As of January 31, 2024, unrealized losses related to individual securities that had been in a continuous loss position for 12 months or longer were insignificant.
The following table summarizes the scheduled maturity for the Company’s marketable securities at January 31, 2024 (in thousands):
|
|
|
|
|
January 31, 2024 |
|
Maturing in one year or less |
$ |
30,047 |
|
Maturing after one year through two years |
|
13,516 |
|
Maturing after two years through three years |
|
8,967 |
|
Total |
$ |
52,530 |
|
4. Accrued Expenses
Accrued expenses consisted of the following as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
April 30, |
|
|
|
2024 |
|
|
2023 |
|
Accrued compensation |
|
$ |
5,465 |
|
|
$ |
4,207 |
|
Accrued research expense |
|
|
7,993 |
|
|
|
3,817 |
|
Accrued professional fees |
|
|
1,247 |
|
|
|
906 |
|
Other accrued expenses |
|
|
135 |
|
|
|
198 |
|
|
|
$ |
14,840 |
|
|
$ |
9,128 |
|
5. Prepaid Expenses and Other Current Assets
Prepaid expenses and other current assets consisted of the following as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
April 30, |
|
|
|
2024 |
|
|
2023 |
|
Prepaid preclinical and clinical activities |
|
$ |
1,871 |
|
|
$ |
1,724 |
|
Other prepaid expenses |
|
|
2,964 |
|
|
|
2,583 |
|
Interest and other receivables |
|
|
408 |
|
|
|
654 |
|
VAT receivable |
|
|
263 |
|
|
|
1,422 |
|
Total prepaid expenses and other current assets |
|
$ |
5,506 |
|
|
$ |
6,383 |
|
6. Commitments and Contingencies
Clinical Studies: The Company enters into contractual agreements with contract research organizations in connection with preclinical and toxicology studies and clinical trials. Amounts due under these agreements are invoiced to the Company on predetermined schedules during the course of the studies and clinical trials and are not refundable regardless of the outcome. The Company has contractual obligations related to the expected future costs to be incurred to complete the ongoing preclinical studies and clinical trials. The remaining clinical commitments, which have cancellation provisions, total $23.3 million at January 31, 2024.
Indemnification: In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for general indemnification. The Company’s exposure under these agreements is unknown because it involves future claims that may be made against the Company but have not yet been made. To date, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may record charges in the future as a result of these indemnification obligations. No amounts associated with such indemnifications have been recorded to date.
Contingencies: From time to time, the Company may have certain contingent liabilities that arise in the ordinary course of business activities. The Company accrues a liability for such matters when it is probable that future expenditures will be made and such expenditures can be reasonably estimated. There were no contingent liabilities requiring accrual at January 31, 2024.
7. Leases
The Company has a lease agreement for approximately 8,300 square feet of space for its headquarters located in Cambridge, Massachusetts that runs through September 2028.
The Company has lease agreements for approximately 13,400 square feet of office and research laboratory space located in Porton Down, United Kingdom that run through April 2028.
The Company has a lease agreement in Salt Lake City, Utah for approximately 6,200 square feet of office space that runs through February 2032.
The Company has a lease agreement for approximately 500 square feet of research laboratory space in Cambridge, Massachusetts that commenced in July 2022 with an option to renew annually.
The Company leases office space in Zug, Switzerland under an initial one-year term which commenced in August 2023. The Company has classified this lease as a short-term lease as the Company concluded that the non-cancelable terms of this lease was less than one year at the commencement.
Total rent expense was approximately $1.4 million and $1.4 million for the nine months ended January 31, 2024 and 2023, respectively and is reflected in general and administrative expenses and research and development expenses as determined by the underlying activities.
The following table summarizes the maturity of undiscounted payments due under lease liabilities and the present value of those liabilities as of January 31, 2024 (in thousands):
|
|
|
|
|
Years ending April 30, |
|
Operating Leases |
|
2024 |
|
$ |
438 |
|
2025 |
|
|
1,775 |
|
2026 |
|
|
1,813 |
|
2027 |
|
|
1,851 |
|
2028 |
|
|
1,847 |
|
Thereafter |
|
|
1,537 |
|
Total minimum lease payments |
|
|
9,261 |
|
Less amounts representing interest |
|
|
1,817 |
|
Present value of minimum payments |
|
|
7,444 |
|
Current portion |
|
|
1,187 |
|
Long-term portion |
|
$ |
6,257 |
|
Note 8. Subsequent Events
In February 2024, the achievement of the performance metric for certain performance-based restricted stock units (“PSUs”) granted in March 2022 and January 2024 with performance criteria based on positive data for the sebetralstat phase 3 KONFIDENT clinical trial were certified by the Compensation Committee of the Company’s Board of Directors (the "Board"). Consequently, 360,000 of these PSUs vested on February 11, 2024 and 76,667 PSUs vested on February 17, 2024. The PSUs were granted under the 2017 Equity Incentive Plan with a grant date fair value of $15.39 for the March 2022 grants and $12.71 for the January 2024 grants.
On February 14, 2024, the Company terminated its “at-the-market” program and sales agreement with Cantor Fitzgerald & Co., under which the Company could, from time to time, offer and sell shares of its common stock having an aggregate offering value of up to $100.0 million. Prior to delivering the written notice, no shares of Company common stock were offered or sold pursuant to this “at-the-market” offering with Cantor Fitzgerald & Co.
Also on February 14, 2024, the Company entered into an underwriting agreement with Jefferies LLC, Leerink Partners LLC, Stifel, Nicolaus & Company, Incorporated, and Cantor Fitzgerald & Co., as the representatives of several underwriters to sell an aggregate of 7,016,312 shares of the Company’s common stock at price of $15.25 per share and pre-funded warrants to purchase up to 3,483,688 shares of the Company’s common stock at a price of $15.249 per pre-funded warrant. The net proceeds from the Underwritten Offering, after deducting estimated expenses, were approximately $150.1 million.
On March 6, 2024, the Board appointed Benjamin L. Palleiko, the Company’s President, Chief Business Officer and Chief Financial Officer, as its Chief Executive Officer and principal executive officer. Mr. Palleiko will remain the Company’s principal financial officer. Mr. Palleiko was also appointed to the Board as a Class I director. Additionally, on March 6, 2024, T. Andrew Crockett announced his resignation from his position as the Chief Executive Officer and from his position on the Board, effective immediately. Mr. Crockett’s resignation is not the result of any disagreement with the Company on any matter relating to the Company’s operations, policies or practices.
Item 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
You should read the following discussion in conjunction with our unaudited interim condensed financial statements and related notes included elsewhere in this report. This Quarterly Report on Form 10-Q contains forward-looking statements that involve risks and uncertainties. All statements other than statements of historical facts contained in this report are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may,” “could,” “will,” “would,” “should,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “intend,” “predict,” “seek,” “contemplate,” “potential” or “continue” or the negative of these terms or other comparable terminology. These forward-looking statements, include, but are not limited to, statements regarding the success, cost and timing of our product development activities and clinical trials as well as other activities we may undertake, global macroeconomic conditions, our business strategy, our ability to receive, maintain and recognize the benefits of certain designations received by product candidates and the receipt and timing of potential regulatory designations, approvals and commercialization of product candidates. Any forward-looking statements in this Quarterly Report on Form 10-Q reflect our current views with respect to future events or our future financial performance, are based on assumptions, and involve known and unknown risks, uncertainties and other factors which may cause our actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Factors that may cause actual results to differ materially from current expectations include, among other things, those listed under “Risk Factors” in our Annual Report on Form 10-K or described elsewhere in this Quarterly Report on Form 10-Q. These forward-looking statements speak only as of the date hereof. Except as required by law, we assume no obligation to update or revise these forward-looking statements for any reason, even if new information becomes available in the future. Unless the context indicates otherwise, in this Quarterly Report on Form 10-Q, the terms “KalVista,” “Company,” “we,” “us” and “our” refer to KalVista Pharmaceuticals, Inc. and, where appropriate, its consolidated subsidiaries.
Management Overview
We are a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors for diseases with significant unmet need. We apply our insights into the chemistry and biology of proteases to develop orally delivered therapeutics with high selectivity, potency, and bioavailability that we believe will make them successful treatments for diseases. We have used these capabilities to develop a novel, small molecule plasma kallikrein inhibitor targeting the disease hereditary angioedema (“HAE”). We also are conducting preclinical development on a novel, oral Factor XIIa (“Factor XIIa”) inhibitor program, which we are initially advancing to provide a next generation of HAE therapeutics, and which also offers the opportunity for expansion into other high unmet need indications in the future.
HAE is a rare and potentially life-threatening, genetically-driven disease that features episodes of debilitating and often painful swelling in the skin, gastrointestinal tract or airways. Although multiple therapies have been approved for the disease, we believe people living with HAE are in need of alternatives that better meet their objectives for quality of life and ease of disease control. Other than one oral therapy approved for prophylaxis, currently marketed therapies are all administered by injection, which patients can find challenging despite their efficacy because they can be painful, time consuming to deliver and difficult to store. As a result, many attacks are treated too late to prevent significant symptoms, and a large percentage are not treated at all, which can lead to needless suffering. We anticipate that there will be strong interest in safe and effective, orally delivered, small molecule treatments, and our strategy is to develop oral drug candidates for both on-demand and prophylactic use with the goal of providing patients with a complete set of oral options to treat their disease.
In February 2024, we announced topline data from the Phase 3 KONFIDENT clinical trial to evaluate the safety and efficacy of sebetralstat as the first potential oral, on-demand therapy for HAE. KONFIDENT was the largest and most representative trial ever conducted in HAE, enrolling a total of 136 patients from 66 clinical sites across 20 countries. Eligible participants included adolescents, patients using long-term prophylaxis, and the trial evaluated all attack severities and locations.
The clinical trial met all primary and key secondary endpoints and demonstrated a favorable safety profile. Primary and key secondary endpoints were analyzed in a fixed, hierarchical sequence and adjusted for multiplicity. HAE attacks treated with both 300 mg and 600 mg of sebetralstat achieved the primary endpoint of beginning of symptom relief significantly faster than placebo (p<0.0001 for 300 mg, p=0.0013 for 600 mg). The median time to beginning of symptom relief was 1.61 hours with sebetralstat 300 mg, 1.79 hours with sebetralstat 600 mg and 6.72 hours with placebo. Both key secondary endpoints were met; attacks treated with sebetralstat 300 mg or 600 mg achieving a significantly faster time to a reduction in attack severity from baseline (p=0.0036 for 300 mg and p=0.0032 for 600 mg) and a significantly faster time to complete attack resolution (p=0.0022 for 300 mg and p<0.0001 for 600 mg) compared to placebo. The KONFIDENT trial had no patient withdrawals due to an adverse event and no treatment-related serious adverse events (SAEs). Consistent with previous studies, sebetralstat was well-tolerated, with a safety profile similar to placebo.
We anticipate submitting a New Drug Application (“NDA”) for sebetralstat to the FDA in the first half of 2024. We also expect to file for approval in the European Union (“E.U.”) and Japan later in 2024.
In addition, we are conducting preclinical development of novel, oral Factor XIIa (“Factor XIIa”) inhibitors, which we are initially advancing to provide a next generation of HAE therapeutics. Factor XIIa also offers the opportunity for future expansion into other high unmet need indications in therapeutic areas outside HAE.
In August 2022, we initiated KONFIDENT-S, a two-year open-label extension trial assessing the long-term safety and tolerability of sebetralstat. In addition, this study is examining the potential use of sebetralstat as short-term prophylaxis in the setting of medical and dental procedures, where HAE attacks are known to be triggered. KONFIDENT-S continues to enroll patients, and we expect to provide a robust safety database to support the planned NDA filing. In total, more than 800 attacks have been treated across KONFIDENT and KONFIDENT-S to date, and KONFIDENT-S includes numerous patients who have taken multiple doses for treatment. We also are developing an oral disintegrating tablet (“ODT”) formulation of sebetralstat and have received FDA feedback on our proposed development program to support a supplemental NDA submission, which did not include a requirement to conduct efficacy trials. We anticipate that the ODT formulation will follow the expected initial launch formulation in the U.S. and E.U. and may become the initial launch formulation in other geographies.
Sebetralstat has received Fast Track and Orphan Drug designations from the FDA, as well as Orphan Drug Designation and an approved Pediatric Investigational Plan from the European Medicines Agency (EMA). In November 2023, sebetralstat was granted Orphan Drug Status in Switzerland. In February 2024, the UK Medicines and Healthcare products Regulatory Agency (MHRA) awarded the Innovation Passport for sebetralstat.
Our oral Factor XIIa inhibitor program targets an enzyme that plays a key role in HAE, as the most upstream mechanism in the biochemical pathway that initiates HAE attacks. For this reason, we believe that inhibition of Factor XIIa will block the underlying mediators of HAE attacks, including the uncontrolled generation of both plasma kallikrein and bradykinin which lead to swelling and pain. Clinical studies of an injectable Factor XIIa-inhibitory antibody have demonstrated a high degree of efficacy in preventing HAE attacks, and there are no known safety implications of long-term inhibition of this enzyme. We believe that our program has the potential to be the first orally delivered Factor XIIa inhibitor to enter clinical development, initially for HAE and over time for additional indications that are supported by scientific evidence. We continue to progress multiple compounds through the discovery phase. Concurrently, we have presented preclinical data supporting potential development in HAE as well as thrombosis and inflammation.
On December 23, 2022, we entered into subscription agreements with institutional investors to sell, in a registered direct offering, an aggregate of 9,484,199 shares of our common stock at a price of $6.00 per share and pre-funded warrants to purchase up to 182,470 shares of common stock at a price of $5.999 per pre-funded warrant. The purchase price per share of each pre-funded warrant represents the per share offering price for the common stock, less the $0.001 per share exercise price of each pre-funded warrant. The net proceeds from the registered direct offering, after deducting estimated expenses, were approximately $57.7 million.
On February 14, 2024, we terminated our “at-the-market” program and sales agreement with Cantor Fitzgerald & Co., under which we could, from time to time, offer and sell shares of our common stock having an aggregate offering value of up to $100.0 million. Prior to delivering the written notice, no shares of our common stock were offered or sold pursuant to this “at-the-market” offering with Cantor Fitzgerald & Co.
On February 14 2024, we entered into an underwriting agreement with Jefferies LLC, Leerink Partners LLC, Stifel, Nicolaus & Company, Incorporated, and Cantor Fitzgerald & Co., as the representatives of several underwriters to sell an aggregate of 7,016,312 shares of our common stock at price of $15.25 per share and pre-funded warrants to purchase up to 3,483,688 shares of common stock at a price of $15.249 per pre-funded warrant (the "Underwritten Offering"). The net proceeds from the Underwritten Offering, after deducting estimated expenses, were approximately $150.1 million.
We have devoted substantially all our efforts to research and development, including clinical trials of our product candidates. We have not completed the development of any product candidates. Pharmaceutical drug product candidates, like those being developed by us, require approvals from the FDA or foreign regulatory agencies prior to commercial sales. There can be no assurance that any product candidates will receive the necessary approvals and any failure to receive approval or delay in approval may have a material adverse impact on our business and financial results. We are subject to a number of risks and uncertainties similar to those of other life science companies developing new products, including, among others, the risks related to the necessity to obtain adequate additional financing, to successfully develop product candidates, to obtain regulatory approval of product candidates, to comply with government regulations, to successfully commercialize our potential products, to the protection of proprietary technology and to our dependence on key individuals.
Financial Overview
Revenue
We have not generated any revenue in the current fiscal year. To date, we have not generated any revenues from the sale of products, and we do not have any products that have been approved for commercialization. We do not expect to generate product revenue unless and until we obtain regulatory approval for, and commercialize, one of our current or future product candidates.
Research and Development Expenses
Research and development expenses primarily consist of costs associated with our research activities, including the preclinical and clinical development of product candidates. We contract with clinical research organizations to manage our clinical trials under agreed upon budgets for each study, with oversight by our clinical program managers. All research and development costs are expensed as incurred.
Costs for certain research and development activities, such as manufacturing development activities and clinical studies are recognized based on the contracted amounts, as adjusted for the percentage of work completed to date. Payments for these activities are based on the terms of the contractual arrangements, which may differ from the pattern of costs incurred, and are reflected on the consolidated balance sheets as prepaid or accrued expenses. We defer and capitalize non-refundable advance payments made for research and development activities until the related goods are delivered or the related services are performed.
We expect to continue to incur substantial expenses related to development activities for the foreseeable future as we conduct clinical development, manufacturing, and toxicology studies. Product candidates in later stages of clinical development generally have higher development costs than those in earlier stages of clinical development, primarily due to the increased size and duration of later-stage clinical trials, additional drug manufacturing requirements, and later stage toxicology studies such as carcinogenicity studies. The process of conducting preclinical studies and clinical trials necessary to obtain regulatory approval is costly and time consuming. The probability of success for each product candidate is affected by numerous factors, including preclinical data, clinical data, competition, manufacturing capability and commercial viability. Accordingly, we may never succeed in achieving marketing approval for any of our product candidates.
Completion dates and costs for clinical development programs as well as our research program can vary significantly for each current and future product candidate and are difficult to predict. As a result, we cannot currently estimate with any degree of certainty the costs associated with development of our product candidates. We anticipate making determinations as to which programs and product candidates to pursue and how much funding to direct to each program and product candidate on an ongoing basis in response to the scientific success of early research programs, results of ongoing and future clinical trials, our ability to enter into collaborative agreements with respect to programs or potential product candidates, as well as ongoing assessments as to the commercial potential of each current or future product candidate.
General and Administrative Expenses
General and administrative expenses consist primarily of the costs associated with general management, obtaining and maintaining our patent portfolio, commercial planning, professional fees for accounting, auditing, consulting and legal services, and general overhead expenses.
We expect ongoing general and administrative expenses to increase in the future as we expand our operating activities, including commercial planning, maintaining and expanding the patent portfolio and incurring additional costs associated with the management of a public company such as maintaining compliance with exchange listing and SEC requirements. These potential increases will likely include management costs, legal fees, accounting fees, directors’ and officers’ liability insurance premiums, and expenses associated with investor relations, among others.
Other Income
Other income consists of interest income earned on bank interest and marketable securities, research and development tax credits from the United Kingdom government’s tax incentive programs set up to encourage research and development in the United Kingdom, realized gains and losses from marketable securities and realized and unrealized exchange rate gains and losses on cash held in foreign currencies and transactions settled in foreign currencies.
Income Taxes
We historically have incurred net losses and had no corporation tax liabilities. We file U.S. Federal tax returns, as well as certain state returns. We also file returns in the United Kingdom. Under the U.K. government’s research and development tax incentive scheme, we have incurred qualifying research and development expenses and filed claims for research and development tax credits in accordance with the relevant tax legislation. The research and development tax credits are paid out to us in cash and reported as other income. Because of the operating losses and the full valuation allowance provided on all deferred tax assets, including the net operating loss carry forward, no income tax provision has been recognized in the three and nine months ended January 31, 2024.
For tax purposes, pursuant to the Tax Cuts and Jobs Act of 2017, the Company is required to capitalize and subsequently amortize all R&D expenditures over five years for research activities conducted in the U.S. and over fifteen years for research activities conducted outside of the U.S. The Company adopted ASU 2019-12 as of January 1, 2022.
Results of Operations
Comparison of the three months ended January 31, 2024 and 2023
The following table sets forth the key components of our results of operations for the three months ended January 31, 2024 and 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended |
|
|
|
|
|
|
|
January 31, |
|
|
Increase |
|
|
|
|
2024 |
|
|
2023 |
|
|
(decrease) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue |
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
|
Operating expenses |
|
|
|
|
|
|
|
|
|
|
Research and development expenses |
|
|
22,523 |
|
|
|
20,063 |
|
|
|
2,460 |
|
|
General and administrative expenses |
|
|
10,628 |
|
|
|
6,882 |
|
|
|
3,746 |
|
|
Other income |
|
|
|
|
|
|
|
|
|
|
Interest, exchange rate gain and other income |
|
|
4,123 |
|
|
|
5,642 |
|
|
|
(1,519 |
) |
|
Revenue. No revenue was recognized in the quarters ended January 31, 2024 or 2023.
Research and Development Expenses. Research and development expenses increased $2.5 million due to increases in spending on personnel costs of $0.7 million and sebetralstat spending of $3.0 million, offset by decreases in spending on KVD824 of $1.8 million and preclinical and other activities of $0.5 million compared to the same period in the prior fiscal year. The impact of exchange rates on research and development expenses resulted in an increase to expenses of $0.7 million in the three months ended January 31, 2024 compared to the same period in the prior fiscal year, which is reflected in the figures above.
Research and development expenses by major programs or categories were as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended |
|
|
|
|
|
|
January 31, |
|
|
Increase |
|
|
|
2024 |
|
|
2023 |
|
|
(decrease) |
|
|
|
|
|
|
|
|
|
|
|
Program-specific costs |
|
|
|
|
|
|
|
Sebetralstat |
|
$ |
10,836 |
|
|
$ |
7,792 |
|
|
$ |
3,044 |
|
KVD824 |
|
|
29 |
|
|
|
1,802 |
|
|
|
(1,773 |
) |
Unallocated costs |
|
|
|
|
|
|
|
|
|
Personnel |
|
|
6,794 |
|
|
|
6,116 |
|
|
|
678 |
|
Preclinical and other activities |
|
|
4,864 |
|
|
|
4,353 |
|
|
|
511 |
|
Total |
|
$ |
22,523 |
|
|
$ |
20,063 |
|
|
$ |
2,460 |
|
Expenses for the sebetralstat program increased primarily due to the Phase 3 KONFIDENT and KONFIDENT-S trials. We anticipate that these expenses will remain at or slightly below current levels due to the completion of the Phase 3 KONFIDENT trial in
February 2024, while the KONFIDENT-S trial continues to enroll participants and we initiate other clinical studies to support the expansion of the sebetralstat commercial opportunity.
Expenses for KVD824 decreased due to the termination of the Phase 2 KOMPLETE clinical trial in October 2022. We anticipate that these expenses will cease in the near term as we do not anticipate any further development of KVD824.
Personnel expenses increased primarily due to higher research and development and medical headcount compared to the same period in the prior year. We anticipate that these expenses will continue to increase for the medical team as we support ongoing development activities and prepare for the planned eventual commercialization of sebetralstat.
Expenses for preclinical and other activities increased primarily due to spending in support of HAE awareness within the medical community. We anticipate that these expenses will continue at or above current levels as we continue development on the oral Factor XIIa inhibitor program and other preclinical activities.
General and Administrative Expenses. General and administrative expenses increased by $3.7 million primarily due to increases in employee related expenses of $2.5 million, commercial planning expenses of $1.1 million, and travel expenses of $0.1 million. We anticipate that expenses will continue at or above current levels as we continue to expand to support the growth of the Company and the planned commercialization of sebetralstat.
Other Income. Other income decreased $1.5 million primarily due to a decrease of $2.2 million in income from research and development tax credits, offset by an increase in foreign currency exchange rate gains of $0.5 million from transactions denominated in foreign currencies in our U.K. subsidiary, and an increase in realized gain from marketable securities of $0.2 million. The decrease in income from research and development credits was driven by the U.K. government's changes to the research and development tax credit program which reduced the payable tax credit of approximately 33.4% of eligible research and development expenditures to 18.6% after April 1, 2023. Additionally, the cash rebate for subcontracted research expenditures are eligible for decreased from approximately 21.7% to 12.1% after April 1, 2023.
Comparison of the nine months ended January 31, 2024 and 2023
The following table sets forth the key components of our results of operations for the nine months ended January 31, 2024 and 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended |
|
|
|
|
|
|
January 31, |
|
|
Increase |
|
|
|
2024 |
|
|
2023 |
|
|
(decrease) |
|
|
|
|
|
|
|
|
|
|
|
Revenue |
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
Operating expenses |
|
|
|
|
|
|
|
|
|
Research and development expenses |
|
|
60,919 |
|
|
|
56,325 |
|
|
|
4,594 |
|
General and administrative expenses |
|
|
31,071 |
|
|
|
22,818 |
|
|
|
8,253 |
|
Other income |
|
|
|
|
|
|
|
|
|
Interest, exchange rate gain and other income |
|
|
9,995 |
|
|
|
12,541 |
|
|
|
(2,546 |
) |
Revenue. No revenue was recognized in the six months ended January 31, 2024 or 2023.
Research and Development Expenses. Research and development expenses increased $4.6 million due to an increase in spending on sebetralstat of $9.7 million and an increase in personnel costs of $2.2 million, offset by decreases in spending on KVD824 of $6.3 million and preclinical activities of $1.1 million as compared to the same period in the prior fiscal year. The impact of exchange rates on research and development expenses resulted in an increase to expenses of $2.1 million in the nine months ended January 31, 2024 compared to the same period in the prior fiscal year, which is reflected in the figures above.
Research and development expenses by major programs or categories were as follows (in thousands):
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended |
|
|
|
|
|
|
January 31, |
|
|
Increase |
|
|
|
2024 |
|
|
2023 |
|
|
(decrease) |
|
|
|
|
|
|
|
|
|
|
|
Program-specific costs |
|
|
|
|
|
|
|
|
|
Sebetralstat |
|
$ |
27,782 |
|
|
$ |
18,094 |
|
|
$ |
9,688 |
|
KVD824 |
|
|
755 |
|
|
|
7,031 |
|
|
|
(6,276 |
) |
Unallocated costs |
|
|
|
|
|
|
|
|
|
Personnel |
|
|
19,978 |
|
|
|
17,746 |
|
|
|
2,232 |
|
Preclinical activities |
|
|
12,404 |
|
|
|
13,454 |
|
|
|
(1,050 |
) |
Total |
|
$ |
60,919 |
|
|
$ |
56,325 |
|
|
$ |
4,594 |
|
Expenses for the sebetralstat program increased primarily due to the Phase 3 KONFIDENT and KONFIDENT-S trials. We anticipate that these expenses will remain at or slightly below current levels due to the completion of the Phase 3 KONFIDENT trial in February 2024, while KONFIDENT-S continues to enroll participants and we initiate other clinical studies to support the expansion of the sebetralstat commercial opportunity
Expenses for KVD824 decreased due to the termination of the Phase 2 KOMPLETE clinical trial in October 2022. We anticipate that these expenses will cease in the near term as we do not anticipate any further development of KVD824.
Personnel expenses increased primarily due to higher research and development and medical headcount compared to the same period in the prior year. We anticipate that these expenses will continue to increase for the medical team as we support ongoing development activities and prepare for the planned eventual commercialization of sebetralstat.
Expenses for preclinical and other activities decreased primarily due to decreased manufacturing costs compared to the same period in the prior year. We anticipate that these expenses will continue at or above current levels as we continue development on the oral Factor XIIa inhibitor program and other preclinical activities.
General and Administrative Expenses. General and administrative expenses increased $8.3 million primarily due to increases in employee related expenses of $5.9 million, commercial planning expenses of $1.8 million, professional fees of $0.3 million, supply chain expenses of $0.1 million, and travel expenses of $0.2 million. We anticipate that expenses will continue at or above current levels as we continue to expand to support the growth of the Company and the planned commercialization of sebetralstat.
Other Income. Other income decreased $2.5 million primarily due to a decrease of $5.2 million in income from research and development tax credits as a result of the tax credit rate change in April 2023. This decrease was offset by increases to realized gains from available for sale securities of $1.2 million, an increase to interest income of $1.0 million, and an increase in foreign currency exchange rate gains of $0.5 million from transactions denominated in foreign currencies in our U.K. subsidiary.
Liquidity and Capital Resources
Since inception, we have not generated any revenue from product sales and have incurred losses since inception and cash outflows from operating activities for the nine months ended January 31, 2024 and 2023. We have funded operations primarily through the issuance of capital stock and pre-funded warrants. Our working capital, primarily cash and marketable securities, is anticipated to fund our operations for at least the next twelve months from the date these unaudited interim condensed consolidated financial statements are issued.
In December 2022, we entered into subscription agreements with institutional investors to sell, in a registered direct offering, an aggregate of 9,484,199 shares of our common stock at a price of $6.00 per share and pre-funded warrants to purchase up to 182,470 shares of common stock at a price of $5.999 per pre-funded warrant. The net proceeds from the registered direct offering, after deducting estimated expenses, were approximately $57.7 million.
In February 2024, we entered into an underwriting agreement with Jefferies LLC, Leerink Partners LLC, Stifel, Nicolaus & Company, Incorporated, and Cantor Fitzgerald & Co., as the representatives of several underwriters to sell an aggregate of 7,016,312 shares of our common stock at price of $15.25 per share and pre-funded warrants to purchase up to 3,483,688 shares of common stock at a price of $15.249 per pre-funded warrant. The net proceeds from the Underwritten Offering, after deducting estimated expenses, were approximately $150.1 million.
Cash Flows
The following table shows a summary of the net cash flow activity for the nine months ended January 31, 2024 and 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended |
|
|
|
January 31, |
|
|
|
2024 |
|
|
2023 |
|
|
|
|
|
Cash flows used in operating activities |
|
$ |
(74,126 |
) |
|
$ |
(52,625 |
) |
Cash flows provided by investing activities |
|
|
41,467 |
|
|
|
47,625 |
|
Cash flows provided by financing activities |
|
|
616 |
|
|
|
58,149 |
|
Effect of exchange rate changes on cash and cash equivalents |
|
|
(1,139 |
) |
|
|
1,168 |
|
Net increase (decrease) in cash and cash equivalents |
|
$ |
(33,182 |
) |
|
$ |
54,317 |
|
Net cash used in operating activities
Net cash used in operating activities was $74.1 million for the nine months ended January 31, 2024 and primarily consisted of a net loss of $82.0 million adjusted for stock-based compensation of $9.2 million, an increase in the research and development tax credit receivable of $6.2 million, realized gains from available for sale securities of $1.1 million, a decrease in prepaid expenses and other assets of $0.9 million and other changes in net working capital. The research and development tax credit receivable increased due to the accrual of tax credits in the nine months ended January 31, 2024. Net cash used in operating activities was $52.6 million for the nine months ended January 31, 2023 and primarily consisted of a net loss of $66.6 million adjusted for stock-based compensation of $7.5 million, a decrease in the research and development tax credit receivable of $2.1 million, a decrease in prepaid expenses and other assets of $4.4 million, and other changes in net working capital.
Net cash provided by investing activities
Net cash provided by investing activities for the nine months ended January 31, 2024 was $41.5 million and primarily consisted of the sales and maturities of marketable securities of $89.5 million offset by purchases of marketable securities of $47.7 million, as compared to $47.6 million provided by investing activities during the same period in the prior year primarily due to the sales and maturities of marketable securities of $112.5 million offset by purchases of marketable securities of $63.8 million.
Net cash provided by financing activities
Net cash provided by financing activities during the nine months ended January 31, 2024 was $0.6 million and consisted of the issuance of common stock from equity incentive plans, compared to $58.2 million in the same period in the prior year which primarily consisted of $57.7 million in net proceeds from the December 2022 registered direct offering of common stock and pre-funded warrants.
Operating Capital Requirements
To date, we have not generated any revenues from the sale of products, and we do not have any products that have been approved for commercialization. We do not expect to generate product revenue unless and until we obtain regulatory approval for, and commercialize, one of our current or future product candidates. We anticipate that we will continue to incur losses for the foreseeable future, and we expect the losses to increase as we continue the development of, and seek regulatory approvals for, product candidates, and begin to commercialize any approved products. We are subject to all of the risks inherent in the development of new therapeutic products, and we may encounter unforeseen expenses, difficulties, complications, delays and other unknown factors that may adversely affect our business. We currently anticipate that, based upon our operating plans and existing capital resources, we have sufficient funding to operate for at least the next twelve months. The amount and timing of our future funding requirements will depend on many factors, including the pace and results of our preclinical and clinical development efforts, future growth to support commercial sales of any approved products, and other activities we may choose to undertake.
Until such time, if ever, as we can generate substantial revenues, we expect to finance our cash needs through a combination of equity and debt financings, collaborations, strategic partnerships, and licensing arrangements. To the extent that additional capital is raised through the sale of stock or convertible debt securities, the ownership interest of existing stockholders will be diluted, and the terms of these newly issued securities may include liquidation or other preferences that adversely affect the rights of common stockholders. Debt financing, if available, may involve agreements that include increased fixed payment obligations and covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making capital expenditures, declaring dividends, selling or licensing intellectual property rights and other operating restrictions that could adversely impact our ability to conduct business. Additional fundraising through collaborations, strategic partnerships or licensing arrangements with third parties may require us to relinquish valuable rights to product candidates, including our other technologies, future revenue streams or research programs, or grant licenses on terms that may not be favorable to us. If we are unable to raise additional funds when needed, we may be required to delay, limit, reduce or terminate product development or future commercialization efforts or grant rights to develop and commercialize other product candidates even if we would otherwise prefer to develop and commercialize such product candidates internally.
Contractual Obligations and Commitments
We enter into contracts in the normal course of business with contract research organizations and clinical trial sites for the conduct of clinical trials, preclinical and clinical studies, professional consultants and other vendors for clinical supply manufacturing or other services. These contracts generally provide for termination on notice, and therefore are cancelable contracts and not included in the table of contractual obligations and commitments in our Annual Report on Form 10-K for the fiscal year ended April 30, 2023, filed with the SEC on July 10, 2023. We are party to several operating leases for office and laboratory space as of January 31, 2024.
Critical Accounting Policies and Significant Judgments and Estimates
Our management’s discussion and analysis of our financial condition and results of operations is based on our financial statements, which we have prepared in accordance with U.S. GAAP. The preparation of our financial statements requires us to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of our financial statements and the reported revenue and expenses during the reported periods. We evaluate these estimates and judgments on an ongoing basis. We base our estimates on historical experience, known trends and events, contractual milestones and various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions. See Note 2 to the unaudited interim condensed consolidated financial statements in Part I, Item 1 of this Quarterly Report on Form 10-Q for a description of our significant accounting policies and assumptions used in applying those policies. The accounting policies and estimates that we deem to be critical are discussed in more detail in our Annual Report on Form 10-K for the fiscal year ended April 30, 2023, filed with the SEC on July 10, 2023.
Recently Issued Accounting Pronouncements
See Note 2 in the Interim Financial Statements for a description of recent accounting pronouncements, including the expected dates of adoption and expected effects on results of operations and financial condition, if known.
Item 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.
We are a smaller reporting company as defined by Rule 12b-2 of the Exchange Act and are not required to provide the information under this item.
Item 4. CONTROLS AND PROCEDURES.
Evaluation of Disclosure Controls and Procedures
As required by Rule 13a-15(b) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), our management, under the supervision and with the participation of our Chief Executive Officer and Chief Financial Officer, has evaluated the effectiveness of the design and operation of our disclosure controls and procedures as of January 31, 2024. The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management, including its principal executive and principal financial officers, as appropriate, to allow timely decisions regarding required disclosure. In designing and evaluating disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable, not absolute assurance of achieving the desired objectives. Also, the design of a control system must reflect the fact that there are resource constraints and the benefits of controls must be considered relative to their costs. Based on that evaluation, our Chief Executive Officer and Chief Financial Officer has concluded that our disclosure controls and procedures were effective as of January 31, 2024.
Changes in Internal Controls over Financial Reporting
There have been no changes in our internal control over financial reporting identified in connection with the evaluation required by Rule 13a-15(d) and 15d-15(d) of the Exchange Act that occurred during the quarter ended January 31, 2024 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
PART II
OTHER INFORMATION
Item 1. LEGAL PROCEEDINGS
From time to time, we may become involved in various lawsuits and legal proceedings which arise in the ordinary course of business. We are currently not aware of any such legal proceedings or claims that we believe will have a material adverse effect on our business, financial condition or operating results.
Item 1A. RISK FACTORS
There have been no material changes to the risk factors described in the section captioned “Part I, Item 1A, Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended April 30, 2023.
In addition to the other information set forth in this report, you should carefully consider the factors discussed in the section captioned “Part I, Item 1A, Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended April 30, 2023 filed with the SEC on July 10, 2023, which may materially affect our business, financial condition, or future results. The risks described in our Annual Report on Form 10-K and in our Quarterly Reports on Form 10-Q are not the only risks we face. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may have a material adverse effect on our business, financial condition, or operating results.
Item 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS
Sales of Unregistered Securities
Not applicable.
Use of Proceeds
None.
Issuer Purchases of Equity Securities
Not applicable.
Item 3. DEFAULTS UPON SENIOR SECURITIES
Not applicable.
Item 4. MINE SAFETY DISCLOSURES
Not applicable.
Item 5. OTHER INFORMATION
(c) Insider Trading Arrangements and Policies
In the third quarter of fiscal 2024, the following trading plans were adopted or terminated:
|
|
|
|
|
|
|
Name |
Title |
Action |
Date |
Intended to satisfy the affirmative defense of Rule 10b5-1? |
Expiration Date |
Total Amount of Common Stock to be Sold Under the Plan |
Chris Yea |
Chief Development Officer |
Adopted |
December 21, 2023 |
Yes(1) |
March 31, 2025 |
50,000 |
(1)The 10b5-1 plan included a representation from the officer to the broker administering the plan that they were not in possession of any material nonpublic information regarding the Company or the securities subject to the plan. A similar representation was made to the Company in connection with the adoption of the plan under the Company’s insider trading policy. Those representations were made as of the date of adoption of the 10b5-1 plan, and speak only as of that date. In making those representations, there is no assurance with respect to any material nonpublic information of which the director/officer was unaware, or with respect to any material nonpublic information acquired by the director/officer or the Company after the date of the representation.
Item 6. EXHIBITS
# This certification is deemed not filed for purpose of Section 18 of the Exchange Act, or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act of 1933, as amended, or the Exchange Act.
SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
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|
|
KALVISTA PHARMACEUTICALS, INC. |
|
|
|
Date: March 11, 2024 |
By: |
/s/ Benjamin L. Palleiko |
|
|
Benjamin L. Palleiko Chief Executive Officer (Principal Executive, Financial and Accounting Officer) |
Exhibit 4.1
KALVISTA PHARMACEUTICALS, INC.
FORM OF WARRANT TO PURCHASE COMMON STOCK
Number of Shares: [ ]
(subject to adjustment)
|
|
|
|
|
|
Warrant No. [ ] |
|
Original Issue Date: [ ], 202[ ] |
KalVista Pharmaceuticals, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [ ] or its registered assigns (the “Holder”), is entitled, subject to the terms set forth below, to purchase from the Company up to a total of [ ] shares of common stock, $0.001 par value per share (the “Common Stock”), of the Company (each such share, a “Warrant Share” and all such shares, the “Warrant Shares”) at an exercise price per share equal to $0.001 per share (as adjusted from time to time as provided in Section 9 herein, the “Exercise Price”) upon surrender of this Warrant to Purchase Common Stock (including any Warrants to Purchase Common Stock issued in exchange, transfer or replacement hereof, the “Warrant”) at any time and from time to time on or after the date hereof (the “Original Issue Date”), subject to the following terms and conditions:
1. Definitions. For purposes of this Warrant, the following terms shall have the following meanings:
(a) “Affiliate” means any Person directly or indirectly controlled by, controlling or under common control with, a Holder, as such terms are used in and construed under Rule 405 under the Securities Act, but only for so long as such control shall continue.
(b) “Commission” means the United States Securities and Exchange Commission.
(c) “Closing Sale Price” means, for any security as of any date, the last trade price for such security on the Principal Trading Market for such security, as reported by Bloomberg L.P., or, if such Principal Trading Market begins to operate on an extended hours basis and does not designate the last trade price, then the last trade price of such security prior to 4:00 P.M., New York City time, as reported by Bloomberg L.P., or if the security is not listed for trading on a national securities exchange or other trading market on the relevant date, the last quoted bid price for the security in the over-the-counter market on the relevant date as reported by OTC Markets Group Inc. (or a similar organization or agency succeeding to its functions of reporting prices). If the Closing Sale Price cannot be calculated for a security on a particular date on any of the foregoing bases, the Closing Sale Price of such security on such date shall be the fair market value as mutually determined by the Company and the Holder. If the Company and the Holder are unable to agree upon the fair market value of such security, then the Board of Directors of the Company shall use its good faith judgment to determine the fair market value. The Board of Directors’ determination shall be binding upon all parties absent demonstrable error. All such determinations shall be appropriately adjusted for any stock dividend, stock split, stock combination or other similar transaction during the applicable calculation period.
(d) “Principal Trading Market” means the national securities exchange or other trading market on which the Common Stock is primarily listed on and quoted for trading, which, as of the Original Issue Date, shall be the Nasdaq Global Market.
(e) “Registration Statement” means the Company’s Registration Statement on Form S-3 (File No. 333-256378), declared effective on June 1, 2021.
(f) “Securities Act” means the Securities Act of 1933, as amended.
(g) “Trading Day” means any weekday on which the Principal Trading Market is open for trading. If the Common Stock is not listed or admitted for trading, “Trading Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or any day on which banking institutions in New York City are authorized or required by law or other governmental action to close.
(h) “Transfer Agent” means Equiniti Trust Company, LLC, the Company’s transfer agent and registrar for the Common Stock, and any successor appointed in such capacity.
2. Issuance of Securities; Registration of Warrants. The Warrant, as initially issued by the Company, is offered and sold pursuant to the Registration Statement. As of the Original Issue Date, the Warrant Shares are issuable under the Registration Statement. Accordingly, the Warrant and, assuming issuance pursuant to the Registration Statement or an exchange meeting the requirements of Section 3(a)(9) of the Securities Exchange Act of 1934 (the “Exchange Act”) as in effect on the Original Issue Date, the Warrant Shares are not “restricted securities” under Rule 144 promulgated under the Securities Act. The Company shall register ownership of this Warrant, upon records to be maintained by the Company for that purpose (the “Warrant Register”), in the name of the record Holder (which shall include the initial Holder or, as the case may be, any assignee to which this Warrant is assigned hereunder) from time to time. The Company may deem and treat the registered Holder of this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any distribution to the Holder, and for all other purposes, absent actual notice to the contrary.
3. Registration of Transfers. Subject to compliance with all applicable securities laws, the Company shall, or will cause its Transfer Agent to, register the transfer of all or any portion of this Warrant in the Warrant Register, upon surrender of this Warrant, and payment for all applicable transfer taxes (if any). Upon any such registration or transfer, a new warrant to purchase Common Stock in substantially the form of this Warrant (any such new warrant, a “New Warrant”) evidencing the portion of this Warrant so transferred shall be issued to the transferee, and a New Warrant evidencing the remaining portion of this Warrant not so transferred, if any, shall be issued to the transferring Holder. The acceptance of the New Warrant by the transferee thereof shall be deemed the acceptance by such transferee of all of the rights and obligations in respect of the New Warrant that the Holder has in respect of this Warrant. The Company shall, or will cause its Transfer Agent to, prepare, issue and deliver at the Company’s own expense any New Warrant under this Section 3. Until due presentment for registration of transfer, the Company may treat the registered Holder hereof as the owner and holder for all purposes, and the Company shall not be affected by any notice to the contrary.
4. Exercise and Duration of Warrants.
(a) All or any part of this Warrant shall be exercisable by the registered Holder in any manner permitted by this Warrant at any time and from time to time on or after the Original Issue Date.
(b) The Holder may exercise this Warrant by delivering to the Company (i) an exercise notice, in the form attached as Schedule 1 hereto (the “Exercise Notice”), completed and duly signed, and (ii) payment of the Exercise Price for the number of Warrant Shares as to which this Warrant is being exercised (which may take the form of a “cashless exercise” if so indicated in the Exercise Notice pursuant to Section 10 below). The date on which such exercise notice is delivered to the Company (as determined in accordance with the notice provisions hereof) is an “Exercise Date.” The Holder shall not be required to deliver the original Warrant in order to effect an exercise hereunder. Execution and delivery of the Exercise Notice shall have the same effect as cancellation of the original Warrant and issuance of a New Warrant evidencing the right to purchase the remaining number of Warrant Shares, if any. The Holder and any assignee, by acceptance of this Warrant, acknowledge and agree that, by reason of the provisions of this paragraph, following the purchase of a portion of the Warrant Shares hereunder, the number of Warrant Shares available for purchase hereunder at any given time may be less than the amount stated on the face hereof.
5. Delivery of Warrant Shares.
(a) Upon exercise of this Warrant, the Company shall promptly (but in no event later than three (3) Trading Days after the Exercise Date), upon the request of the Holder, cause the Transfer Agent to credit such aggregate number of shares of Common Stock to which the Holder is entitled pursuant to such exercise to the Holder’s or its designee’s balance account with The Depository Trust Company (“DTC”) through its Deposit Withdrawal Agent Commission system, or if the Transfer Agent is not participating in the Fast Automated Securities Transfer Program (the “FAST Program”) or if the certificates are required to bear a legend regarding restriction on transferability, issue and dispatch by overnight courier to the address as specified in the Exercise Notice, a certificate, registered in the Company’s share register in the name of the Holder or its designee, for the number of shares of Common Stock to which the Holder is entitled pursuant to such exercise. The Holder, or any natural person or legal entity (each, a “Person”) so designated by the Holder to receive Warrant Shares, shall be deemed to have become the holder of record of such Warrant Shares as of the Exercise Date, irrespective of the date such Warrant Shares are credited to the Holder’s DTC account or the date of delivery of the certificates evidencing such Warrant Shares, as the case may be.
(b) To the extent permitted by law, the Company’s obligations to cause the Transfer Agent to issue and deliver Warrant Shares in accordance with and subject to the terms hereof (including the limitations set forth in Section 11 below) are absolute and unconditional, irrespective of any action or inaction by the Holder to enforce the same, any waiver or consent with respect to any provision hereof, the recovery of any judgment against any Person or any action to enforce the same, or any setoff, counterclaim, recoupment, limitation or termination, or any breach or alleged breach by the Holder or any other Person of any obligation to the Company or any violation or alleged violation of law by the Holder or any other Person, and irrespective of any other circumstance that might otherwise limit such obligation of the Company to the Holder in connection with the issuance of Warrant Shares. Nothing herein shall limit the Holder’s right to pursue any other remedies available to it hereunder, at law or in equity including, without
limitation, a decree of specific performance and/or injunctive relief with respect to the Company’s failure to timely deliver certificates representing shares of Common Stock upon exercise of the Warrant as required pursuant to the terms hereof.
6. Charges, Taxes and Expenses. Issuance and delivery of certificates for shares of Common Stock, if any, upon exercise of this Warrant shall be made without charge to the Holder for any issue or transfer tax, transfer agent fee or other incidental tax or expense (excluding any applicable stamp duties) in respect of the issuance of such certificates, all of which taxes and expenses shall be paid by the Company; provided, however, that the Company shall not be required to pay any tax that may be payable in respect of any transfer involved in the registration of any certificates for Warrant Shares or the Warrants in a name other than that of the Holder or an Affiliate thereof. The Holder shall be responsible for all other tax liability that may arise as a result of holding or transferring this Warrant or receiving Warrant Shares upon exercise hereof.
7. Replacement of Warrant. If this Warrant is mutilated, lost, stolen or destroyed, the Company shall issue or cause to be issued in exchange and substitution for and upon cancellation hereof, or in lieu of and substitution for this Warrant, a New Warrant, but only upon receipt of evidence reasonably satisfactory to the Company of such loss, theft or destruction (in such case) and, in each case, a customary and reasonable indemnity and surety bond, if requested by the Company. Applicants for a New Warrant under such circumstances shall also comply with such other reasonable regulations and procedures and pay such other reasonable third-party costs as the Company may prescribe. If a New Warrant is requested as a result of a mutilation of this Warrant, then the Holder shall deliver such mutilated Warrant to the Company as a condition precedent to the Company’s obligation to issue the New Warrant.
8. Reservation of Warrant Shares. The Company covenants that it will, at all times while this Warrant is outstanding, reserve and keep available out of the aggregate of its authorized but unissued and otherwise unreserved Common Stock, solely for the purpose of enabling it to issue Warrant Shares upon exercise of this Warrant as herein provided, the number of Warrant Shares that are initially issuable and deliverable upon the exercise of this entire Warrant, free from preemptive rights or any other contingent purchase rights of persons other than the Holder (taking into account the adjustments and restrictions of Section 9). The Company covenants that all Warrant Shares so issuable and deliverable shall, upon issuance and the payment of the applicable Exercise Price in accordance with the terms hereof, be duly and validly authorized, issued and fully paid and non-assessable. The Company will take all such action as may be reasonably necessary to assure that such shares of Common Stock may be issued as provided herein without violation of any applicable law or regulation, or of any requirements of any securities exchange or automated quotation system upon which the Common Stock may be listed. The Company further covenants that it will not, without the prior written consent of the Holder, take any actions to increase the par value of the Common Stock at any time while this Warrant is outstanding.
9. Certain Adjustments. The Exercise Price and number of Warrant Shares issuable upon exercise of this Warrant are subject to adjustment from time to time as set forth in this Section 9.
(a) Stock Dividends and Splits. If the Company, at any time while this Warrant is outstanding, (i) pays a stock dividend on its Common Stock or otherwise makes a distribution on any class of capital stock issued and outstanding on the Original Issue Date and in accordance with the terms of such stock on the Original Issue Date or as amended, as described in the Registration Statement, that is payable in shares of Common Stock, (ii) subdivides its outstanding shares of Common Stock into a larger number of shares of Common Stock, (iii) combines its outstanding shares of Common Stock into a smaller number of shares of Common Stock or (iv) issues by reclassification of shares of capital stock any additional shares of Common Stock of the Company, then in each such case the Exercise Price shall be multiplied by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding immediately before such event and the denominator of which shall be the number of shares of Common Stock outstanding immediately after such event. Any adjustment made pursuant to clause (i) of this paragraph shall become effective immediately after the record date for the determination of stockholders entitled to receive such dividend or distribution, provided, however, that if such record date shall have been fixed and such dividend is not fully paid on the date fixed therefor, the Exercise Price shall be recomputed accordingly as of the close of business on such record date and thereafter the Exercise Price shall be adjusted pursuant to this paragraph as of the time of actual payment of such dividends. Any adjustment pursuant to clause (ii) or (iii) of this paragraph shall become effective immediately after the effective date of such subdivision or combination.
(b) Pro Rata Distributions. If the Company, at any time while this Warrant is outstanding, distributes to all holders of Common Stock for no consideration (i) evidences of its indebtedness, (ii) any security (other than a distribution of Common Stock covered by the preceding paragraph), (iii) rights or warrants to subscribe for or purchase any security, or (iv) cash or any other asset (in each case, a “Distribution”), other than a reclassification as to which Section 9(c) applies, then in each such case, the Holder shall be entitled to participate in such Distribution to the same extent that the Holder would have participated therein if the Holder had held the number of shares of Common Stock acquirable upon complete exercise of this Warrant (without regard to any limitations on exercise hereof, including without limitation, the ownership limitation set forth in Section 11(a) hereof) immediately before the date of which a record is taken for such Distribution, or, if no such record is taken, the date as of which the record holders of Common Stock are to be determined for the participation in such Distribution; provided, however, to the extent that the Holder’s right to participate in any such Distribution would result in the Holder exceeding the ownership limitation set forth in Section 11(a) hereof, then the Holder shall not be entitled to participate in such Distribution to such extent (or in the beneficial ownership of any Common Stock as a result of such
Distribution to such extent) and the portion of such Distribution shall be held in abeyance for the benefit of the Holder until the earlier of (i) such time, if ever, as the delivery to such Holder of such portion would not result in the Holder exceeding the ownership limitation set forth in Section 11(a) hereof and (ii) such time as the Holder has exercised this Warrant.
(c) Fundamental Transactions. If, at any time while this Warrant is outstanding (i) the Company effects any merger or consolidation of the Company with or into another Person, in which the Company is not the surviving entity and in which the stockholders of the Company immediately prior to such merger or consolidation do not own, directly or indirectly, at least 50% of the voting power of the surviving entity immediately after such merger or consolidation, (ii) the Company effects any sale to another Person of all or substantially all of its assets in one transaction or a series of related transactions, (iii) pursuant to any tender offer or exchange offer (whether by the Company or another Person), holders of capital stock tender shares representing more than 50% of the voting power of the capital stock of the Company and the Company or such other Person, as applicable, accepts such tender for payment, (iv) the Company consummates a stock purchase agreement or other business combination (including, without limitation, a reorganization, recapitalization, spin-off or scheme of arrangement) with another Person whereby such other Person acquires more than the 50% of the voting power of the capital stock of the Company (except for any such transaction in which the stockholders of the Company immediately prior to such transaction maintain, in substantially the same proportions, the voting power of such Person immediately after the transaction) or (v) the Company effects any reclassification of the Common Stock or any compulsory share exchange pursuant to which the Common Stock is effectively converted into or exchanged for other securities, cash or property (other than as a result of a subdivision or combination of shares of Common Stock covered by Section 9(a) above) (in any such case, a “Fundamental Transaction”), then following such Fundamental Transaction the Holder shall have the right to receive, upon exercise of this Warrant, the same amount and kind of securities, cash or property as it would have been entitled to receive upon the occurrence of such Fundamental Transaction if it had been, immediately prior to such Fundamental Transaction, the holder of the number of Warrant Shares then issuable upon exercise in full of this Warrant without regard to any limitations on exercise contained herein (the “Alternate Consideration”). The Company shall not effect any Fundamental Transaction in which the Company is not the surviving entity or the Alternate Consideration includes securities of another Person unless (i) the Alternate Consideration is solely cash and the Company provides for the simultaneous “cashless exercise” of this Warrant pursuant to Section 10 below or (ii) prior to or simultaneously with the consummation thereof, any successor to the Company, surviving entity or other Person (including any purchaser of assets of the Company) shall assume the obligation to deliver to the Holder such Alternate Consideration as, in accordance with the foregoing provisions, the Holder may be entitled to receive, and the other obligations under this Warrant. The provisions of this paragraph (c) shall similarly apply to subsequent transactions analogous of a Fundamental Transaction type.
(d) Number of Warrant Shares. Simultaneously with any adjustment to the Exercise Price pursuant to Section 9 (including any adjustment to the Exercise Price that would have been effected but for the final sentence in this paragraph (d)), the number of Warrant Shares that may be purchased upon exercise of this Warrant shall be increased or decreased proportionately, so that after such adjustment the aggregate Exercise Price payable hereunder for the increased or decreased number of Warrant Shares shall be the same as the aggregate Exercise Price in effect immediately prior to such adjustment. Notwithstanding the foregoing, in no event may the Exercise Price be adjusted below the par value of the Common Stock then in effect.
(e) Calculations. All calculations under this Section 9 shall be made to the nearest one-hundredth of one cent or the nearest share, as applicable.
(f) Notice of Adjustments. Upon the occurrence of each adjustment pursuant to this Section 9, the Company at its expense will, at the written request of the Holder, promptly compute such adjustment, in good faith, in accordance with the terms of this Warrant and prepare a certificate setting forth such adjustment, including a statement of the adjusted Exercise Price and adjusted number or type of Warrant Shares or other securities issuable upon exercise of this Warrant (as applicable), describing the transactions giving rise to such adjustments and showing in detail the facts upon which such adjustment is based. Upon written request, the Company will promptly deliver a copy of each such certificate to the Holder and to the Company’s Transfer Agent.
(g) Notice of Corporate Events. If, while this Warrant is outstanding, the Company (i) declares a dividend or any other distribution of cash, securities or other property in respect of its Common Stock, including, without limitation, any granting of rights or warrants to subscribe for or purchase any capital stock of the Company or any subsidiary, (ii) authorizes or approves, enters into any agreement contemplating or solicits stockholder approval for any Fundamental Transaction or (iii) authorizes the voluntary dissolution, liquidation or winding up of the affairs of the Company, then, except if such notice and the contents thereof shall be deemed to constitute material non-public information, the Company shall deliver to the Holder a notice of such transaction at least ten (10) days prior to the applicable record or effective date on which a Person would need to hold Common Stock in order to participate in or vote with respect to such transaction; provided, however, that the failure to deliver such notice or any defect therein shall not affect the validity of the corporate action required to be described in such notice. In addition, if while this Warrant is outstanding, the Company authorizes or approves, enters into any agreement contemplating or solicits stockholder approval for any Fundamental Transaction contemplated by Section 9(c), other than a Fundamental Transaction under clause (iii) of Section 9(c), then, except if such notice and the contents thereof shall be deemed to constitute material non-public information, the Company shall deliver to the Holder a notice of such Fundamental Transaction at least ten (10) days prior to the date such Fundamental Transaction is consummated.
Holder agrees to maintain any information disclosed pursuant to this Section 9(g) in confidence until such information is publicly available, and shall comply with applicable law with respect to trading in the Company’s securities following receipt of any such information.
10. Payment of Cashless Exercise Price. Notwithstanding anything contained herein to the contrary, the Holder may, in its sole discretion, satisfy its obligation to pay the Exercise Price through a “cashless exercise,” in which event the Company shall issue to the Holder the number of Warrant Shares in an exchange of securities effected pursuant to Section 3(a)(9) of the Securities Act as determined as follows:
X = Y [(A-B)/A]
where:
“X” equals the number of Warrant Shares to be issued to the Holder;
“Y” equals the total number of Warrant Shares with respect to which this Warrant is then being exercised;
“A” equals the Closing Sale Price per share of Common Stock as of the Trading Day on the date immediately preceding the Exercise Date; and
“B” equals the Exercise Price per Warrant Share then in effect on the Exercise Date.
For purposes of Rule 144 promulgated under the Securities Act, it is intended, understood and acknowledged that the Warrant Shares issued in such a “cashless exercise” transaction shall be deemed to have been acquired by the Holder, and the holding period for the Warrant Shares shall be deemed to have commenced, on the date this Warrant was originally issued (provided that the Commission continues to take the position that such treatment is proper at the time of such exercise). In the event that the Registration Statement or another registration statement registering the issuance of Warrant Shares is, for any reason, not effective at the time of exercise of this Warrant, then the Warrant may only be exercised through a cashless exercise, as set forth in this Section 10.
In no event will the exercise of this Warrant be settled in cash.
11. Limitations on Exercise.
(a) Notwithstanding anything to the contrary contained herein, the Company shall not effect any exercise of this Warrant, and the Holder shall not be entitled to exercise this Warrant for a number of Warrant Shares in excess of that number of Warrant Shares which, upon giving effect or immediately prior to such exercise, would cause (i) the aggregate number of shares of Common Stock beneficially owned by the Holder, its Affiliates and any other Persons whose beneficial ownership of Common Stock would be aggregated with the Holder’s for purposes of Section 13(d) of the Exchange Act to exceed [4.99]%[9.99]% (the “Maximum Percentage”) of the total number of issued and outstanding shares of Common Stock of the Company following such exercise, or (ii) the combined voting power of the securities of the Company beneficially owned by the Holder and its Affiliates and any other Persons whose beneficial ownership of Common Stock would be aggregated with the Holder’s for purposes of Section 13(d) of the Exchange Act to exceed 9.99% of the combined voting power of all of the securities of the Company then outstanding following such exercise. For purposes of this Warrant, in determining the number of outstanding shares of Common Stock, the Holder may rely on the number of outstanding shares of Common Stock as reflected in (x) the Company’s most recent Form 10-Q or Form 10-K, as the case may be, filed with the Commission prior to the Exercise Date, (y) a more recent public announcement by the Company or (z) any other notice by the Company or its Transfer Agent setting forth the number of shares of Common Stock outstanding. Upon the written request of the Holder, the Company shall within three (3) Trading Days confirm in writing or by electronic mail to the Holder the number of shares of Common Stock then outstanding. In any case, the number of outstanding shares of Common Stock shall be determined after giving effect to the conversion or exercise of securities of the Company, including this Warrant, by the Holder since the date as of which such number of outstanding shares of Common Stock was reported. By written notice to the Company, the Holder may from time to time increase or decrease the Maximum Percentage to any other percentage, not in excess of 19.99%, specified in such notice; provided that any such increase or decrease will not be effective until the sixty-first (61st) day after such notice is delivered to the Company. For purposes of this Section 11(a), the aggregate number of shares of Common Stock or voting securities beneficially owned by the Holder and its Affiliates and any other Persons whose beneficial ownership of Common Stock would be aggregated with the Holder’s for purposes of Section 13(d) of the Exchange Act shall include the shares of Common Stock issuable upon the exercise of this Warrant with respect to which such determination is being made, but shall exclude the number of shares of Common Stock which would be issuable upon (x) exercise of the remaining unexercised and non-cancelled portion of this Warrant by the Holder and (y) exercise or conversion of the unexercised, non-converted or non-cancelled portion of any other securities of the Company that do not have voting power (including without limitation any securities of the Company which would entitle the holder thereof to acquire at any time Common Stock, including without limitation any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock), is
subject to a limitation on conversion or exercise analogous to the limitation contained herein and is beneficially owned by the Holder or any of its Affiliates and other Persons whose beneficial ownership of Common Stock would be aggregated with the Holder’s for purposes of Section 13(d) of the Exchange Act.
(b) This Section 11 shall not restrict the number of shares of Common Stock which a Holder may receive or beneficially own in order to determine the amount of securities or other consideration that such Holder may receive in the event of a Fundamental Transaction as contemplated in Section 9(c) of this Warrant.
12. No Fractional Shares. No fractional Warrant Shares will be issued in connection with any exercise of this Warrant. In lieu of any fractional shares that would otherwise be issuable, the number of Warrant Shares to be issued shall be rounded down to the next whole number.
13. Notices. Any and all notices or other communications or deliveries hereunder (including, without limitation, any Exercise Notice) shall be in writing and shall be deemed given and effective on the earliest of (i) the date of transmission, if such notice or communication is delivered via facsimile or confirmed e-mail prior to 5:30 P.M., New York City time, on a Trading Day, (ii) the next Trading Day after the date of transmission, if such notice or communication is delivered via facsimile or confirmed e-mail on a day that is not a Trading Day or later than 5:30 P.M., New York City time, on any Trading Day, (iii) the Trading Day following the date of mailing, if sent by nationally recognized overnight courier service specifying next business day delivery, or (iv) upon actual receipt by the Person to whom such notice is required to be given, if by hand delivery. The addresses, facsimile numbers and e-mail addresses for such communications shall be:
If to the Company:
KalVista Pharmaceuticals , Inc.
Attention: Chief Financial Officer
55 Cambridge Parkway
Suite 901E, Cambridge, MA 02142
Telephone: (857) 999-0890
Fax: (866) 553-3269
Email: ben.palleiko@kalvista.com
If to the Holder, to its address, facsimile number or e-mail address set forth herein or on the books and records of the Company.
Or, in each of the above instances, to such other address, facsimile number or e-mail address as the recipient party has specified by written notice given to each other party at least five (5) days prior to the effectiveness of such change.
14. Warrant Agent. The Company shall initially serve as warrant agent under this Warrant. Upon ten (10) days’ notice to the Holder, the Company may appoint a new warrant agent. Any corporation into which the Company or any new warrant agent may be merged or any corporation resulting from any consolidation to which the Company or any new warrant agent shall be a party or any corporation to which the Company or any new warrant agent transfers substantially all of its corporate trust or shareholders services business shall be a successor warrant agent under this Warrant without any further act. Any such successor warrant agent shall promptly cause notice of its succession as warrant agent to be mailed (by first class mail, postage prepaid) to the Holder at the Holder’s last address as shown on the Warrant Register.
15. Miscellaneous.
(a) No Rights as a Stockholder. The Holder, solely in such Person’s capacity as a holder of this Warrant, shall not be entitled to vote or receive dividends or be deemed the holder of share capital of the Company for any purpose, nor shall anything contained in this Warrant be construed to confer upon the Holder, solely in such Person’s capacity as the Holder of this Warrant, any of the rights of a stockholder of the Company or any right to vote, give or withhold consent to any corporate action (whether any reorganization, issue of stock, reclassification of stock, consolidation, merger, amalgamation, conveyance or otherwise), receive notice of meetings, receive dividends or subscription rights, or otherwise, prior to the issuance to the Holder of the Warrant Shares which such Person is then entitled to receive upon the due exercise of this Warrant. In addition, nothing contained in this Warrant shall be construed as imposing any liabilities on the Holder to purchase any securities (upon exercise of this Warrant or otherwise) or as a stockholder of the Company, whether such liabilities are asserted by the Company or by creditors of the Company.
(b) Authorized Shares. Except and to the extent as waived or consented to by the Holder, the Company shall not by any action, including, without limitation, amending its certificate or articles of incorporation or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the
taking of all such actions as may be necessary or appropriate to protect the rights of Holder as set forth in this Warrant against impairment. Without limiting the generality of the foregoing, the Company will (a) not increase the par value of any Warrant Shares above the amount payable therefor upon such exercise immediately prior to such increase in par value, (b) take all such action as may be necessary or appropriate in order that the Company may validly and legally issue fully paid and non-assessable Warrant Shares upon the exercise of this Warrant, and (c) use commercially reasonable efforts to obtain all such authorizations, exemptions or consents from any public regulatory body having jurisdiction thereof as may be necessary to enable the Company to perform its obligations under this Warrant.
(c) Successors and Assigns. Subject to compliance with applicable securities laws, this Warrant may be assigned by the Holder. This Warrant may not be assigned by the Company without the written consent of the Holder, except to a successor in the event of a Fundamental Transaction. This Warrant shall be binding on and inure to the benefit of the Company and the Holder and their respective successors and assigns. Subject to the preceding sentence, nothing in this Warrant shall be construed to give to any Person other than the Company and the Holder any legal or equitable right, remedy or cause of action under this Warrant. This Warrant may be amended only in writing signed by the Company and the Holder, or their successors and assigns.
(d) Amendment and Waiver. Except as otherwise provided herein, the provisions of the Warrants may be amended and the Company may take any action herein prohibited, or omit to perform any act herein required to be performed by it, only if the Company has obtained the written consent of the Holder.
(e) Acceptance. Receipt of this Warrant by the Holder shall constitute acceptance of and agreement to all of the terms and conditions contained herein.
(f) Governing Law; Jurisdiction. ALL QUESTIONS CONCERNING THE CONSTRUCTION, VALIDITY, ENFORCEMENT AND INTERPRETATION OF THIS WARRANT SHALL BE GOVERNED BY AND CONSTRUED AND ENFORCED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF. EACH OF THE COMPANY AND THE HOLDER HEREBY IRREVOCABLY SUBMITS TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS SITTING IN THE CITY OF NEW YORK, BOROUGH OF MANHATTAN, FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR WITH ANY TRANSACTION CONTEMPLATED HEREBY OR DISCUSSED HEREIN (INCLUDING WITH RESPECT TO THE ENFORCEMENT OF ANY OF THE TRANSACTION DOCUMENTS), AND HEREBY IRREVOCABLY WAIVES, AND AGREES NOT TO ASSERT IN ANY SUIT, ACTION OR PROCEEDING, ANY CLAIM THAT IT IS NOT PERSONALLY SUBJECT TO THE JURISDICTION OF ANY SUCH COURT. EACH OF THE COMPANY AND THE HOLDER HEREBY IRREVOCABLY WAIVES PERSONAL SERVICE OF PROCESS AND CONSENTS TO PROCESS BEING SERVED IN ANY SUCH SUIT, ACTION OR PROCEEDING BY MAILING A COPY THEREOF VIA REGISTERED OR CERTIFIED MAIL OR OVERNIGHT DELIVERY (WITH EVIDENCE OF DELIVERY) TO SUCH PERSON AT THE ADDRESS IN EFFECT FOR NOTICES TO IT AND AGREES THAT SUCH SERVICE SHALL CONSTITUTE GOOD AND SUFFICIENT SERVICE OF PROCESS AND NOTICE THEREOF. NOTHING CONTAINED HEREIN SHALL BE DEEMED TO LIMIT IN ANY WAY ANY RIGHT TO SERVE PROCESS IN ANY MANNER PERMITTED BY LAW. EACH OF THE COMPANY AND THE HOLDER HEREBY WAIVES ALL RIGHTS TO A TRIAL BY JURY.
(g) Headings. The headings herein are for convenience only, do not constitute a part of this Warrant and shall not be deemed to limit or affect any of the provisions hereof.
(h) Severability. In case any one or more of the provisions of this Warrant shall be invalid or unenforceable in any respect, the validity and enforceability of the remaining terms and provisions of this Warrant shall not in any way be affected or impaired thereby, and the Company and the Holder will attempt in good faith to agree upon a valid and enforceable provision which shall be a commercially reasonable substitute therefor, and upon so agreeing, shall incorporate such substitute provision in this Warrant.
[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]
IN WITNESS WHEREOF, the Company has caused this Warrant to be duly executed by its authorized officer as of the date first indicated above.
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KALVISTA PHARMACEUTICALS, INC. |
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By: |
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Name: Benjamin L. Palleiko |
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Title: President, Chief Business Officer and Chief Financial Officer |
SCHEDULE 1
FORM OF EXERCISE NOTICE
[To be executed by the Holder to purchase shares of Common Stock under the Warrant]
Ladies and Gentlemen:
(1) The undersigned is the Holder of Warrant No. (the “Warrant”) issued by KalVista Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used herein and not otherwise defined herein have the respective meanings set forth in the Warrant.
(2) The undersigned hereby exercises its right to purchase ___________Warrant Shares pursuant to the Warrant.
(3) The Holder intends that payment of the Exercise Price shall be made as (check one):
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“Cashless Exercise” under Section 10 of the Warrant |
(4) If the Holder has elected a Cash Exercise, the Holder shall pay the sum of $____________ in immediately available funds to the Company in accordance with the terms of the Warrant.
(5) Pursuant to this Exercise Notice, the Company shall deliver to the Holder Warrant Shares determined in accordance with the terms of the Warrant. The Warrant Shares shall be delivered to the following DWAC Account Number:
(6) By its delivery of this Exercise Notice, the undersigned represents and warrants to the Company that in giving effect to the exercise evidenced hereby the Holder will not beneficially own in excess of the number of shares of Common Stock (as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended) permitted to be owned under Section 11(a) of the Warrant to which this notice relates.
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(Signature must conform in all respects to name of Holder as specified on the face of the Warrant)
Exhibit 31.1
CERTIFICATION PURSUANT TO
RULES 13a-14(a) OR 15d-14(a) OF THE SECURITIES EXCHANGE ACT OF 1934,
AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, Benjamin L. Palleiko, certify that:
1.I have reviewed this quarterly report on Form 10-Q of KalVista Pharmaceuticals, Inc.;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a.Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b.Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c.Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d.Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5.The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
a.All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
b.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
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Date: March 11, 2024 |
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/s/ Benjamin L. Palleiko |
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Benjamin L Palleiko Chief Executive Officer (Principal Executive, Financial and Accounting Officer) |
Exhibit 32.1
CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF
THE SARBANES-OXLEY ACT OF 2002
In connection with the accompanying Quarterly Report of KalVista Pharmaceuticals Inc. (the “Company”) on Form 10-Q for the fiscal quarter ended January 31, 2024 (the “Report”), I, Benjamin L. Palleiko, as Chief Executive Officer, Principal Executive Officer, Principal Financial Officer and Principal Accounting Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of my knowledge:
(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and
(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the periods presented therein.
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Date: March 11, 2024 |
/s/ Benjamin L. Palleiko |
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Benjamin L. Palleiko |
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Chief Executive Officer |
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(Principal Executive, Financial and Accounting Officer) |
v3.24.0.1
Document and Entity Information - shares
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9 Months Ended |
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Jan. 31, 2024 |
Feb. 29, 2024 |
Cover [Abstract] |
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Document Type |
10-Q
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Amendment Flag |
false
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Document Period End Date |
Jan. 31, 2024
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Document Fiscal Year Focus |
2024
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Document Fiscal Period Focus |
Q3
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Trading Symbol |
KALV
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Entity Registrant Name |
KALVISTA PHARMACEUTICALS, INC.
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Entity Central Index Key |
0001348911
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Current Fiscal Year End Date |
--04-30
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Entity Filer Category |
Non-accelerated Filer
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Entity Small Business |
true
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Entity Emerging Growth Company |
false
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Entity Current Reporting Status |
Yes
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Entity Interactive Data Current |
Yes
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Entity Shell Company |
false
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Document Quarterly Report |
true
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Title of 12(b) Security |
Common Stock, $0.001 par value per share
|
|
Security Exchange Name |
NASDAQ
|
|
Document Transition Report |
false
|
|
Entity File Number |
001-36830
|
|
Entity Incorporation, State or Country Code |
DE
|
|
Entity Tax Identification Number |
20-0915291
|
|
Entity Address, Address Line One |
55 Cambridge Parkway
|
|
Entity Address, Address Line Two |
Suite 901E
|
|
Entity Address, City or Town |
Cambridge
|
|
Entity Address, State or Province |
MA
|
|
Entity Address, Postal Zip Code |
02142
|
|
City Area Code |
857
|
|
Local Phone Number |
999-0075
|
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Entity Common Stock, Shares Outstanding |
|
42,188,296
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v3.24.0.1
Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands |
Jan. 31, 2024 |
Apr. 30, 2023 |
Current assets: |
|
|
Cash and cash equivalents |
$ 23,056
|
$ 56,238
|
Marketable securities |
52,530
|
93,137
|
Research and development tax credit receivable |
23,011
|
16,568
|
Prepaid expenses and other current assets |
5,506
|
6,383
|
Total current assets |
104,103
|
172,326
|
Property and equipment, net |
2,423
|
2,948
|
Right of use assets |
7,045
|
7,822
|
Other assets |
397
|
106
|
Total assets |
113,968
|
183,202
|
Current liabilities: |
|
|
Accounts payable |
3,101
|
4,817
|
Accrued expenses |
14,840
|
9,128
|
Lease liability - current portion |
1,187
|
1,087
|
Total current liabilities |
19,128
|
15,032
|
Long-term liabilities: |
|
|
Lease liability - net of current portion |
6,257
|
7,145
|
Total long-term liabilities |
6,257
|
7,145
|
Commitments and contingencies (Note 6) |
|
|
Stockholders’ equity |
|
|
Common stock, $0.001 par value, 100,000,000 authorized Shares issued and outstanding: 34,595,623 at January 31, 2024 and 34,171,138 at April 30, 2023 |
34
|
34
|
Additional paid-in capital |
516,920
|
507,133
|
Accumulated deficit |
(425,077)
|
(343,082)
|
Accumulated other comprehensive loss |
(3,294)
|
(3,060)
|
Total stockholders’ equity |
88,583
|
161,025
|
Total liabilities and stockholders’ equity |
$ 113,968
|
$ 183,202
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v3.24.0.1
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|
Jan. 31, 2024 |
Apr. 30, 2023 |
Statement of Financial Position [Abstract] |
|
|
Common stock, par value |
$ 0.001
|
$ 0.001
|
Common stock, shares authorized |
100,000,000
|
100,000,000
|
Common stock, shares issued |
34,595,623
|
34,171,138
|
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34,595,623
|
34,171,138
|
X |
- DefinitionFace amount or stated value per share of common stock.
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v3.24.0.1
Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Jan. 31, 2024 |
Jan. 31, 2023 |
Jan. 31, 2024 |
Jan. 31, 2023 |
Operating expenses: |
|
|
|
|
Research and development |
$ 22,523
|
$ 20,063
|
$ 60,919
|
$ 56,325
|
General and administrative |
10,628
|
6,882
|
31,071
|
22,818
|
Total operating expenses |
33,151
|
26,945
|
91,990
|
79,143
|
Operating loss |
(33,151)
|
(26,945)
|
(91,990)
|
(79,143)
|
Other income: |
|
|
|
|
Interest income |
684
|
732
|
2,383
|
1,424
|
Foreign currency exchange gain (loss) |
1,120
|
597
|
277
|
(237)
|
Other income |
2,319
|
4,313
|
7,335
|
11,354
|
Total other income |
4,123
|
5,642
|
9,995
|
12,541
|
Net loss |
(29,028)
|
(21,303)
|
(81,995)
|
(66,602)
|
Other comprehensive (loss) income: |
|
|
|
|
Foreign currency translation (loss) gain |
(46)
|
1,128
|
(373)
|
(573)
|
Unrealized holding gain on marketable securities |
438
|
658
|
1,270
|
808
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
(221)
|
(1)
|
(1,130)
|
84
|
Other comprehensive gain (loss) |
171
|
1,785
|
(233)
|
319
|
Comprehensive loss |
$ (28,857)
|
$ (19,518)
|
$ (82,228)
|
$ (66,283)
|
Net loss per share to common stockholders, basic |
$ (0.84)
|
$ (0.75)
|
$ (2.37)
|
$ (2.58)
|
Net loss per share to common stockholders, diluted |
$ (0.84)
|
$ (0.75)
|
$ (2.37)
|
$ (2.58)
|
Weighted average common shares outstanding, basic |
34,723,379
|
28,278,453
|
34,567,853
|
25,810,369
|
Weighted average common shares outstanding, diluted |
34,723,379
|
28,278,453
|
34,567,853
|
25,810,369
|
X |
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v3.24.0.1
Condensed Consolidated Statement of Changes in Stockholders' Equity (Unaudited) - USD ($) $ in Thousands |
Total |
Common Stock [Member] |
Additional Paid-in Capital [Member] |
Accumulated Deficit [Member] |
Accumulated Other Comprehensive Loss [Member] |
Balance at Apr. 30, 2022 |
$ 185,093
|
$ 25
|
$ 439,104
|
$ (250,175)
|
$ (3,861)
|
Balance, shares at Apr. 30, 2022 |
|
24,550,748
|
|
|
|
Issuance of common stock from equity incentive plans |
168
|
|
168
|
|
|
Issuance of common stock from equity incentive plans, shares |
|
20,124
|
|
|
|
Stock-based compensation expense |
2,642
|
|
2,642
|
|
|
Net loss |
(23,042)
|
|
|
(23,042)
|
|
Foreign currency translation gain (loss) |
(403)
|
|
|
|
(403)
|
Unrealized holding gain from marketable securities |
98
|
|
|
|
98
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
16
|
|
|
|
16
|
Balance at Jul. 31, 2022 |
164,572
|
$ 25
|
441,914
|
(273,217)
|
(4,150)
|
Balance, shares at Jul. 31, 2022 |
|
24,570,872
|
|
|
|
Balance at Apr. 30, 2022 |
185,093
|
$ 25
|
439,104
|
(250,175)
|
(3,861)
|
Balance, shares at Apr. 30, 2022 |
|
24,550,748
|
|
|
|
Net loss |
(66,602)
|
|
|
|
|
Foreign currency translation gain (loss) |
(573)
|
|
|
|
|
Unrealized holding gain from marketable securities |
808
|
|
|
|
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
84
|
|
|
|
|
Balance at Jan. 31, 2023 |
184,441
|
$ 34
|
504,725
|
(316,777)
|
(3,541)
|
Balance, shares at Jan. 31, 2023 |
|
34,127,762
|
|
|
|
Balance at Jul. 31, 2022 |
164,572
|
$ 25
|
441,914
|
(273,217)
|
(4,150)
|
Balance, shares at Jul. 31, 2022 |
|
24,570,872
|
|
|
|
Issuance of common stock from equity incentive plans |
168
|
|
168
|
|
|
Issuance of common stock from equity incentive plans, shares |
|
31,151
|
|
|
|
Stock-based compensation expense |
2,506
|
|
2,506
|
|
|
Net loss |
(22,257)
|
|
|
(22,257)
|
|
Foreign currency translation gain (loss) |
(1,297)
|
|
|
|
(1,297)
|
Unrealized holding gain from marketable securities |
52
|
|
|
|
52
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
69
|
|
|
|
69
|
Balance at Oct. 31, 2022 |
143,813
|
$ 25
|
444,588
|
(295,474)
|
(5,326)
|
Balance, shares at Oct. 31, 2022 |
|
24,602,023
|
|
|
|
Issuance of common stock from equity incentive plans |
146
|
|
146
|
|
|
Issuance of common stock from equity incentive plans, shares |
|
41,540
|
|
|
|
Issuance of common stock, net of issuance costs of $0.3 million |
56,582
|
$ 9
|
56,573
|
|
|
Issuance of common stock, net of issuance costs of $0.3 million, shares |
|
9,484,199
|
|
|
|
Issuance of pre-funded warrants for the purchase of common stock, net of issuance costs |
1,085
|
|
1,085
|
|
|
Stock-based compensation expense |
2,333
|
|
2,333
|
|
|
Net loss |
(21,303)
|
|
|
(21,303)
|
|
Foreign currency translation gain (loss) |
1,128
|
|
|
|
1,128
|
Unrealized holding gain from marketable securities |
658
|
|
|
|
658
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
(1)
|
|
|
|
(1)
|
Balance at Jan. 31, 2023 |
184,441
|
$ 34
|
504,725
|
(316,777)
|
(3,541)
|
Balance, shares at Jan. 31, 2023 |
|
34,127,762
|
|
|
|
Balance at Apr. 30, 2023 |
161,025
|
$ 34
|
507,133
|
(343,082)
|
(3,060)
|
Balance, shares at Apr. 30, 2023 |
|
34,171,138
|
|
|
|
Issuance of common stock from equity incentive plans |
204
|
|
204
|
|
|
Issuance of common stock from equity incentive plans, shares |
|
35,313
|
|
|
|
Release of restricted stock units, shares |
|
60,144
|
|
|
|
Stock-based compensation expense |
3,254
|
|
3,254
|
|
|
Net loss |
(25,317)
|
|
|
(25,317)
|
|
Foreign currency translation gain (loss) |
91
|
|
|
|
91
|
Unrealized holding gain from marketable securities |
392
|
|
|
|
392
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
(314)
|
|
|
|
(314)
|
Balance at Jul. 31, 2023 |
139,335
|
$ 34
|
510,591
|
(368,399)
|
(2,891)
|
Balance, shares at Jul. 31, 2023 |
|
34,266,595
|
|
|
|
Balance at Apr. 30, 2023 |
161,025
|
$ 34
|
507,133
|
(343,082)
|
(3,060)
|
Balance, shares at Apr. 30, 2023 |
|
34,171,138
|
|
|
|
Net loss |
(81,995)
|
|
|
|
|
Foreign currency translation gain (loss) |
(373)
|
|
|
|
|
Unrealized holding gain from marketable securities |
1,270
|
|
|
|
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
(1,130)
|
|
|
|
|
Balance at Jan. 31, 2024 |
88,583
|
$ 34
|
516,920
|
(425,077)
|
(3,294)
|
Balance, shares at Jan. 31, 2024 |
|
34,595,623
|
|
|
|
Balance at Jul. 31, 2023 |
139,335
|
$ 34
|
510,591
|
(368,399)
|
(2,891)
|
Balance, shares at Jul. 31, 2023 |
|
34,266,595
|
|
|
|
Issuance of common stock from equity incentive plans |
128
|
|
128
|
|
|
Issuance of common stock from equity incentive plans, shares |
|
18,000
|
|
|
|
Release of restricted stock units, shares |
|
136,863
|
|
|
|
Stock-based compensation expense |
3,207
|
|
3,207
|
|
|
Net loss |
(27,650)
|
|
|
(27,650)
|
|
Foreign currency translation gain (loss) |
(419)
|
|
|
|
(419)
|
Unrealized holding gain from marketable securities |
440
|
|
|
|
440
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
(595)
|
|
|
|
(595)
|
Balance at Oct. 31, 2023 |
114,446
|
$ 34
|
513,926
|
(396,049)
|
(3,465)
|
Balance, shares at Oct. 31, 2023 |
|
34,421,458
|
|
|
|
Issuance of common stock from equity incentive plans |
283
|
|
283
|
|
|
Issuance of common stock from equity incentive plans, shares |
|
36,914
|
|
|
|
Release of restricted stock units, shares |
|
137,251
|
|
|
|
Stock-based compensation expense |
2,711
|
|
2,711
|
|
|
Net loss |
(29,028)
|
|
|
(29,028)
|
|
Foreign currency translation gain (loss) |
(46)
|
|
|
|
(46)
|
Unrealized holding gain from marketable securities |
438
|
|
|
|
438
|
Reclassification adjustment for realized (gain) loss on marketable securities included in net loss |
(221)
|
|
|
|
(221)
|
Balance at Jan. 31, 2024 |
$ 88,583
|
$ 34
|
$ 516,920
|
$ (425,077)
|
$ (3,294)
|
Balance, shares at Jan. 31, 2024 |
|
34,595,623
|
|
|
|
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v3.24.0.1
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands |
9 Months Ended |
Jan. 31, 2024 |
Jan. 31, 2023 |
Cash flows from operating activities |
|
|
Net loss |
$ (81,995)
|
$ (66,602)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Depreciation and amortization |
597
|
530
|
Stock-based compensation expense |
9,172
|
7,481
|
Realized (gain) loss from sale of marketable securities |
(1,130)
|
84
|
Non-cash operating lease expense |
(11)
|
52
|
Amortization of premium on marketable securities |
88
|
890
|
Foreign currency exchange loss (gain) |
596
|
(1,339)
|
Changes in operating assets and liabilities: |
|
|
Research and development tax credit receivable |
(6,215)
|
2,049
|
Prepaid expenses and other assets |
906
|
4,440
|
Accounts payable |
(1,778)
|
(1,911)
|
Accrued expenses |
5,644
|
1,701
|
Net cash used in operating activities |
(74,126)
|
(52,625)
|
Cash flows from investing activities |
|
|
Purchases of marketable securities |
(47,687)
|
(63,757)
|
Sales and maturities of marketable securities |
89,475
|
112,509
|
Acquisition of property and equipment |
(27)
|
(1,127)
|
Website development costs |
(294)
|
|
Net cash provided by investing activities |
41,467
|
47,625
|
Cash flows from financing activities |
|
|
Issuance of common stock from equity incentive plans |
616
|
482
|
Issuance of common stock, net of offering expenses of $0.3 million |
|
56,582
|
Issuance of pre-funded warrants, net of offering expenses |
|
1,085
|
Net cash provided by financing activities |
616
|
58,149
|
Effect of exchange rate changes on cash and cash equivalents |
(1,139)
|
1,168
|
Net (decrease) increase in cash and cash equivalents |
(33,182)
|
54,317
|
Cash and cash equivalents at beginning of period |
56,238
|
30,732
|
Cash and cash equivalents at end of period |
$ 23,056
|
85,049
|
Supplemental disclosures of non-cash activities: |
|
|
Right of use assets obtained in exchange for operating lease liabilities |
|
$ 1,192
|
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v3.24.0.1
Pay vs Performance Disclosure - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Jan. 31, 2024 |
Oct. 31, 2023 |
Jul. 31, 2023 |
Jan. 31, 2023 |
Oct. 31, 2022 |
Jul. 31, 2022 |
Jan. 31, 2024 |
Jan. 31, 2023 |
Pay vs Performance Disclosure |
|
|
|
|
|
|
|
|
Net Income (Loss) |
$ (29,028)
|
$ (27,650)
|
$ (25,317)
|
$ (21,303)
|
$ (22,257)
|
$ (23,042)
|
$ (81,995)
|
$ (66,602)
|
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v3.24.0.1
Insider Trading Arrangements
|
3 Months Ended |
Jan. 31, 2024
shares
|
Trading Arrangements, by Individual |
|
Material Terms of Trading Arrangement |
(c) Insider Trading Arrangements and Policies In the third quarter of fiscal 2024, the following trading plans were adopted or terminated:
|
|
|
|
|
|
|
Name |
Title |
Action |
Date |
Intended to satisfy the affirmative defense of Rule 10b5-1? |
Expiration Date |
Total Amount of Common Stock to be Sold Under the Plan |
Chris Yea |
Chief Development Officer |
Adopted |
December 21, 2023 |
Yes(1) |
March 31, 2025 |
50,000 |
(1)The 10b5-1 plan included a representation from the officer to the broker administering the plan that they were not in possession of any material nonpublic information regarding the Company or the securities subject to the plan. A similar representation was made to the Company in connection with the adoption of the plan under the Company’s insider trading policy. Those representations were made as of the date of adoption of the 10b5-1 plan, and speak only as of that date. In making those representations, there is no assurance with respect to any material nonpublic information of which the director/officer was unaware, or with respect to any material nonpublic information acquired by the director/officer or the Company after the date of the representation.
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|
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Chief Development Officer
|
Rule 10b5-1 Arrangement Adopted |
true
|
Adoption Date |
December 21, 2023
|
Termination Date |
March 31, 2025
|
Aggregate Available |
50,000
|
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v3.24.0.1
The Company
|
9 Months Ended |
Jan. 31, 2024 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
The Company |
Company Background KalVista Pharmaceuticals, Inc. (“Company”) is a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors for diseases with significant unmet need. The Company applies its insights into the chemistry and biology of proteases to develop orally delivered, small molecule inhibitors with high selectivity, potency, and bioavailability that it believes will make them successful treatments for disease. The Company’s initial focus is on developing novel, oral therapeutics targeting hereditary angioedema (HAE). In February 2024, the Company announced topline data from the Phase 3 KONFIDENT clinical trial evaluating the safety and efficacy of sebetralstat as the first potential oral, on-demand therapy for HAE. KONFIDENT was the largest and most representative trial ever conducted in HAE, enrolling a total of 136 patients from 66 clinical sites across 20 countries. Eligible participants included adolescents, patients using long-term prophylaxis, and the trial evaluated all attack severities and locations. The clinical trial met all primary and key secondary endpoints and demonstrated a favorable safety profile. Primary and key secondary endpoints were analyzed in a fixed, hierarchical sequence and adjusted for multiplicity. HAE attacks treated with both 300 mg and 600 mg of sebetralstat achieved the primary endpoint of beginning of symptom relief significantly faster than placebo (p<0.0001 for 300 mg, p=0.0013 for 600 mg). The median time to beginning of symptom relief was 1.6 hours with sebetralstat 300 mg, 1.8 hours with sebetralstat 600 mg and 6.7 hours with placebo. Key secondary endpoints showed that attacks treated with sebetralstat 300 mg or 600 mg achieved a significantly faster time to reduction in attack severity from baseline, compared to placebo (p=0.0036 for 300 mg and p=0.0032 for 600 mg). Attacks treated with sebetralstat 300 mg or 600 mg demonstrated a significantly faster time to complete attack resolution, compared to placebo (p=0.0022 for 300 mg and p<0.0001 for 600 mg). The KONFIDENT trial had no patient withdrawals due to an adverse event and no treatment-related serious adverse events (SAEs). Consistent with previous studies, sebetralstat was well-tolerated, with a safety profile similar to placebo. The Company anticipates submitting a New Drug Application (“NDA”) for sebetralstat to the FDA in the first half of 2024. The Company also expects to file for approval in the European Union (“E.U.”) and Japan later in 2024. In addition, the Company is conducting preclinical development of novel, oral Factor XIIa (“Factor XIIa”) inhibitors, which the Company initially is advancing to provide a next generation of HAE therapeutics. Factor XIIa also offers the opportunity for future expansion into other high unmet need indications in therapeutic areas outside HAE. The Company’s headquarters is located in Cambridge, Massachusetts, with additional offices located in Porton Down, United Kingdom, Salt Lake City, Utah, and Zug, Switzerland. Liquidity The Company has devoted substantially all of its efforts to research and development, including preclinical and clinical trials of sebetralstat. The Company has not completed the development of any product candidates or commenced commercial operations. Pharmaceutical drug product candidates, like those being developed by the Company, require approvals from the FDA or foreign regulatory agencies prior to commercial sales. There can be no assurance that any product candidates will receive the necessary approvals and any failure to receive approval or delay in approval may have a material adverse impact on the Company’s business and financial results. The Company is subject to a number of risks and uncertainties similar to those of other life science companies developing new products, including, among others, the risks related to the necessity to obtain adequate additional financing, to successfully develop product candidates, to obtain regulatory approval of product candidates, to comply with government regulations, to successfully commercialize its potential products, to the protection of proprietary technology and to the dependence on key individuals. To date, the Company has not generated any product sales revenues and does not have any products that have been approved for commercialization. As of January 31, 2024, the Company had an accumulated deficit of $425.1 million and $75.6 million of cash, cash equivalents and marketable securities. The Company does not expect to generate significant revenue unless and until it obtains regulatory approval for, and commercializes, one of its current or future product candidates. The Company anticipates that it will continue to incur losses for the foreseeable future, and it expects those losses to increase as it continues the development of, and seeks regulatory approvals for, product candidates, and begins to commercialize any approved products. The Company is subject to all of the risks inherent in the development of new therapeutic products, and it may encounter unforeseen expenses, difficulties, complications, delays, and other unknown factors that may adversely affect its business. On February 14, 2024, the Company entered into an underwriting agreement with Jefferies LLC, Leerink Partners LLC, Stifel, Nicolaus & Company, Incorporated, and Cantor Fitzgerald & Co., as the representatives of several underwriters to sell an aggregate of 7,016,312 shares of the Company’s common stock at price of $15.25 per share and pre-funded warrants to purchase up to 3,483,688 shares of common stock at a price of $15.249 per pre-funded warrant (the "Underwritten Offering"). The net proceeds from the Underwritten Offering, after deducting estimated expenses, were approximately $150.1 million. The Company currently anticipates that, based upon its operating plans and existing capital resources, it has sufficient funding to operate for at least the next twelve months. The Company will need to expend substantial resources for research and development, including costs associated with the clinical testing of its product candidates and will need to obtain additional financing to fund its operations and to conduct trials for its product candidates. The Company will seek to finance future cash needs through equity offerings, future grants, corporate partnerships, and product sales. The Company has never been profitable and has incurred significant operating losses in each year since its inception. Cash requirements may vary materially from those now planned because of changes in the Company’s focus and direction of its research and development programs, competitive and technical advances, patent developments, regulatory changes, or other developments. Additional financing will be required to continue operations after the Company exhausts its current cash resources and to continue its long-term plans for clinical trials and new product development. There can be no assurance that any such financing can be obtained by the Company, or if obtained, what the terms thereof may be, or that any amount that the Company is able to raise will be adequate to support the Company's working capital requirements until it achieves profitable operations. If adequate additional working capital is not secured when needed, the Company may be required to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible and/or suspend or curtail planned research programs. Any of these actions could materially harm the Company’s business and prospects.
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v3.24.0.1
Summary of Significant Accounting Policies
|
9 Months Ended |
Jan. 31, 2024 |
Accounting Policies [Abstract] |
|
Summary of Significant Accounting Policies |
2.Summary of Significant Accounting Policies Principles of Consolidation: The accompanying unaudited interim condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation. The accompanying unaudited interim condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) for interim financial information and in accordance with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. Such financial statements reflect all adjustments that are, in management’s opinion, necessary to present fairly, in all material respects, the Company’s consolidated financial position, results of operations, and cash flows. The unaudited interim condensed consolidated financial statements have been prepared on the same basis as the annual financial statements. There were no adjustments other than normal recurring adjustments. These unaudited interim condensed consolidated financial results are not necessarily indicative of the results to be expected for the year ending April 30, 2024, or for any other future annual or interim period. The accompanying unaudited interim condensed consolidated financial statements should be read in conjunction with the audited financial statements as of and for the year ended April 30, 2023 in the Company’s Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”) on July 10, 2023. Segment Reporting: The chief operating decision maker, the CEO, manages the Company’s operations as a single operating segment for the purposes of assessing performance and making operating decisions. Recent Accounting Pronouncements: In June 2016, the FASB issued ASU 2016-13, Financial Instruments-Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments, which amends the impairment model by requiring entities to use a forward-looking approach on expected losses to estimate credit losses on certain financial instruments, including trade receivables and available-for-sale debt securities. This guidance became effective on May 1, 2023 and did not have a material impact to the consolidated financial statements. As the Company has never recorded any other-than-temporary-impairment adjustments to its available-for-sale debt securities prior to the effective date, no transition provisions were applicable to the Company. Net Loss per Share: Basic net loss per share is computed by dividing the net loss by the weighted average number of common shares outstanding during the period. Diluted net loss per share is computed by dividing net loss by the sum of the weighted average number of common shares and the number of potential dilutive common share equivalents outstanding during the period. Potential dilutive common share equivalents consist of the incremental common shares issuable upon the exercise of share options and awards. Potential dilutive common share equivalents consist of:
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
|
2024 |
|
|
2023 |
|
Stock options and awards |
|
|
6,229,313 |
|
|
|
5,386,625 |
|
The Company uses the treasury stock method to calculate the weighted average shares used in computing diluted net loss per share. In computing diluted earnings per share, common share equivalents are not considered in periods in which a net loss is reported, as the inclusion of the common share equivalents would be anti-dilutive. As a result, there is no difference between the Company’s basic and diluted loss per share for the periods presented. The weighted average number of common shares used in the basic and diluted net loss per common share calculations includes the weighted-average pre-funded warrants outstanding during the period as they are exercisable at any time for nominal cash consideration. Fair Value Measurement: The Company classifies fair value measurements using a three-level hierarchy that prioritizes the inputs used to measure fair value. This hierarchy requires entities to maximize the use of observable inputs and minimize the use of unobservable inputs. The three levels of inputs used to measure fair value are as follows: Level 1, quoted market prices in active markets for identical assets or liabilities; Level 2, observable inputs other than quoted market prices included in Level 1, such as quoted market prices for markets that are not active or other inputs that are observable or can be corroborated by observable market data; and Level 3, unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities, including certain pricing models, discounted cash flow methodologies and similar techniques that use significant unobservable inputs. These fair values are obtained from independent pricing services which utilize Level 1 and Level 2 inputs. The following tables summarize the cash equivalents and marketable securities measured at fair value on a recurring basis as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
January 31, 2024 |
|
Cash equivalents |
$ |
57 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
57 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
Corporate debt securities |
|
— |
|
|
|
48,339 |
|
|
|
— |
|
|
|
48,339 |
|
U.S. government agency securities |
|
— |
|
|
|
4,191 |
|
|
|
— |
|
|
|
4,191 |
|
|
$ |
57 |
|
|
$ |
52,530 |
|
|
$ |
— |
|
|
$ |
52,587 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
April 30, 2023 |
|
Cash equivalents |
$ |
31,507 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
31,507 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
Corporate debt securities |
|
— |
|
|
|
77,967 |
|
|
|
— |
|
|
|
77,967 |
|
U.S. government agency securities |
|
— |
|
|
|
15,170 |
|
|
|
— |
|
|
|
15,170 |
|
|
$ |
31,507 |
|
|
$ |
93,137 |
|
|
$ |
— |
|
|
$ |
124,644 |
|
|
X |
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v3.24.0.1
Marketable Securities
|
9 Months Ended |
Jan. 31, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
Marketable Securities |
The objectives of the Company’s investment policy are to ensure the safety and preservation of invested funds, as well as to maintain liquidity sufficient to meet cash flow requirements. The Company invests its excess cash in securities issued by financial institutions, commercial companies, and government agencies that management believes to be of high credit quality in order to limit the amount of its credit exposure. The Company has not realized any material losses from its investments. The Company classifies all of its debt securities as available-for-sale. Unrealized gains and losses on investments are recognized in accumulated comprehensive loss, unless an unrealized loss is considered to be other than temporary, in which case the unrealized loss is charged to operations. The Company periodically reviews its investments for other than temporary declines in fair value below cost basis and whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. The Company believes the individual unrealized losses represent temporary declines primarily resulting from interest rate changes. Realized gains and losses are included in other income in the consolidated statements of operations and comprehensive loss and are determined using the specific identification method with transactions recorded on a trade date basis. The following tables summarize the fair values of the Company’s investments by type as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
January 31, 2024 |
|
|
Amortized |
|
|
Unrealized |
|
|
Unrealized |
|
|
Estimated |
|
|
Cost |
|
|
Gains |
|
|
Losses |
|
|
Fair Value |
|
Corporate debt securities |
$ |
47,827 |
|
|
$ |
525 |
|
|
$ |
(13 |
) |
|
$ |
48,339 |
|
Obligations of the U.S. Government and its agencies |
|
4,178 |
|
|
|
13 |
|
|
|
— |
|
|
|
4,191 |
|
Total |
$ |
52,005 |
|
|
$ |
538 |
|
|
$ |
(13 |
) |
|
$ |
52,530 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
April 30, 2023 |
|
|
Amortized |
|
|
Unrealized |
|
|
Unrealized |
|
|
Estimated |
|
|
Cost |
|
|
Gains |
|
|
Losses |
|
|
Fair Value |
|
Corporate debt securities |
$ |
77,768 |
|
|
$ |
367 |
|
|
$ |
(168 |
) |
|
$ |
77,967 |
|
Obligations of the U.S. Government and its agencies |
|
15,094 |
|
|
|
76 |
|
|
|
|
|
|
15,170 |
|
Total |
$ |
92,862 |
|
|
$ |
443 |
|
|
$ |
(168 |
) |
|
$ |
93,137 |
|
The Company has classified all of its available-for-sale investment securities, including those with maturities beyond one year, as current assets on its condensed consolidated balance sheets based on the highly liquid nature of the investment securities and because these investment securities are considered available for use in current operations. As of January 31, 2024, unrealized losses related to individual securities that had been in a continuous loss position for 12 months or longer were insignificant. The following table summarizes the scheduled maturity for the Company’s marketable securities at January 31, 2024 (in thousands):
|
|
|
|
|
January 31, 2024 |
|
Maturing in one year or less |
$ |
30,047 |
|
Maturing after one year through two years |
|
13,516 |
|
Maturing after two years through three years |
|
8,967 |
|
Total |
$ |
52,530 |
|
|
X |
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v3.24.0.1
Accrued Expenses
|
9 Months Ended |
Jan. 31, 2024 |
Payables and Accruals [Abstract] |
|
Accrued Expenses |
4. Accrued Expenses Accrued expenses consisted of the following as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
April 30, |
|
|
|
2024 |
|
|
2023 |
|
Accrued compensation |
|
$ |
5,465 |
|
|
$ |
4,207 |
|
Accrued research expense |
|
|
7,993 |
|
|
|
3,817 |
|
Accrued professional fees |
|
|
1,247 |
|
|
|
906 |
|
Other accrued expenses |
|
|
135 |
|
|
|
198 |
|
|
|
$ |
14,840 |
|
|
$ |
9,128 |
|
|
X |
- DefinitionThe entire disclosure for accounts payable and accrued liabilities at the end of the reporting period.
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v3.24.0.1
Prepaid Expenses and Other Current Assets
|
9 Months Ended |
Jan. 31, 2024 |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] |
|
Prepaid Expenses and Other Current Assets |
5. Prepaid Expenses and Other Current Assets Prepaid expenses and other current assets consisted of the following as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
April 30, |
|
|
|
2024 |
|
|
2023 |
|
Prepaid preclinical and clinical activities |
|
$ |
1,871 |
|
|
$ |
1,724 |
|
Other prepaid expenses |
|
|
2,964 |
|
|
|
2,583 |
|
Interest and other receivables |
|
|
408 |
|
|
|
654 |
|
VAT receivable |
|
|
263 |
|
|
|
1,422 |
|
Total prepaid expenses and other current assets |
|
$ |
5,506 |
|
|
$ |
6,383 |
|
|
X |
- DefinitionThe entire disclosure for prepaid expense and other current assets.
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v3.24.0.1
Commitments and Contingencies
|
9 Months Ended |
Jan. 31, 2024 |
Commitments and Contingencies Disclosure [Abstract] |
|
Commitments and Contingencies |
6. Commitments and Contingencies Clinical Studies: The Company enters into contractual agreements with contract research organizations in connection with preclinical and toxicology studies and clinical trials. Amounts due under these agreements are invoiced to the Company on predetermined schedules during the course of the studies and clinical trials and are not refundable regardless of the outcome. The Company has contractual obligations related to the expected future costs to be incurred to complete the ongoing preclinical studies and clinical trials. The remaining clinical commitments, which have cancellation provisions, total $23.3 million at January 31, 2024. Indemnification: In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for general indemnification. The Company’s exposure under these agreements is unknown because it involves future claims that may be made against the Company but have not yet been made. To date, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may record charges in the future as a result of these indemnification obligations. No amounts associated with such indemnifications have been recorded to date. Contingencies: From time to time, the Company may have certain contingent liabilities that arise in the ordinary course of business activities. The Company accrues a liability for such matters when it is probable that future expenditures will be made and such expenditures can be reasonably estimated. There were no contingent liabilities requiring accrual at January 31, 2024.
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v3.24.0.1
Leases
|
9 Months Ended |
Jan. 31, 2024 |
Leases [Abstract] |
|
Leases |
7. Leases The Company has a lease agreement for approximately 8,300 square feet of space for its headquarters located in Cambridge, Massachusetts that runs through September 2028. The Company has lease agreements for approximately 13,400 square feet of office and research laboratory space located in Porton Down, United Kingdom that run through April 2028. The Company has a lease agreement in Salt Lake City, Utah for approximately 6,200 square feet of office space that runs through February 2032. The Company has a lease agreement for approximately 500 square feet of research laboratory space in Cambridge, Massachusetts that commenced in July 2022 with an option to renew annually. The Company leases office space in Zug, Switzerland under an initial one-year term which commenced in August 2023. The Company has classified this lease as a short-term lease as the Company concluded that the non-cancelable terms of this lease was less than one year at the commencement. Total rent expense was approximately $1.4 million and $1.4 million for the nine months ended January 31, 2024 and 2023, respectively and is reflected in general and administrative expenses and research and development expenses as determined by the underlying activities. The following table summarizes the maturity of undiscounted payments due under lease liabilities and the present value of those liabilities as of January 31, 2024 (in thousands):
|
|
|
|
|
Years ending April 30, |
|
Operating Leases |
|
2024 |
|
$ |
438 |
|
2025 |
|
|
1,775 |
|
2026 |
|
|
1,813 |
|
2027 |
|
|
1,851 |
|
2028 |
|
|
1,847 |
|
Thereafter |
|
|
1,537 |
|
Total minimum lease payments |
|
|
9,261 |
|
Less amounts representing interest |
|
|
1,817 |
|
Present value of minimum payments |
|
|
7,444 |
|
Current portion |
|
|
1,187 |
|
Long-term portion |
|
$ |
6,257 |
|
|
X |
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v3.24.0.1
Subsequent Event
|
9 Months Ended |
Jan. 31, 2024 |
Subsequent Events [Abstract] |
|
Subsequent Event |
Note 8. Subsequent Events In February 2024, the achievement of the performance metric for certain performance-based restricted stock units (“PSUs”) granted in March 2022 and January 2024 with performance criteria based on positive data for the sebetralstat phase 3 KONFIDENT clinical trial were certified by the Compensation Committee of the Company’s Board of Directors (the "Board"). Consequently, 360,000 of these PSUs vested on February 11, 2024 and 76,667 PSUs vested on February 17, 2024. The PSUs were granted under the 2017 Equity Incentive Plan with a grant date fair value of $15.39 for the March 2022 grants and $12.71 for the January 2024 grants. On February 14, 2024, the Company terminated its “at-the-market” program and sales agreement with Cantor Fitzgerald & Co., under which the Company could, from time to time, offer and sell shares of its common stock having an aggregate offering value of up to $100.0 million. Prior to delivering the written notice, no shares of Company common stock were offered or sold pursuant to this “at-the-market” offering with Cantor Fitzgerald & Co. Also on February 14, 2024, the Company entered into an underwriting agreement with Jefferies LLC, Leerink Partners LLC, Stifel, Nicolaus & Company, Incorporated, and Cantor Fitzgerald & Co., as the representatives of several underwriters to sell an aggregate of 7,016,312 shares of the Company’s common stock at price of $15.25 per share and pre-funded warrants to purchase up to 3,483,688 shares of the Company’s common stock at a price of $15.249 per pre-funded warrant. The net proceeds from the Underwritten Offering, after deducting estimated expenses, were approximately $150.1 million. On March 6, 2024, the Board appointed Benjamin L. Palleiko, the Company’s President, Chief Business Officer and Chief Financial Officer, as its Chief Executive Officer and principal executive officer. Mr. Palleiko will remain the Company’s principal financial officer. Mr. Palleiko was also appointed to the Board as a Class I director. Additionally, on March 6, 2024, T. Andrew Crockett announced his resignation from his position as the Chief Executive Officer and from his position on the Board, effective immediately. Mr. Crockett’s resignation is not the result of any disagreement with the Company on any matter relating to the Company’s operations, policies or practices.
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v3.24.0.1
Summary of Significant Accounting Policies (Policies)
|
9 Months Ended |
Jan. 31, 2024 |
Accounting Policies [Abstract] |
|
Principles of Consolidation |
Principles of Consolidation: The accompanying unaudited interim condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation. The accompanying unaudited interim condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) for interim financial information and in accordance with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. Such financial statements reflect all adjustments that are, in management’s opinion, necessary to present fairly, in all material respects, the Company’s consolidated financial position, results of operations, and cash flows. The unaudited interim condensed consolidated financial statements have been prepared on the same basis as the annual financial statements. There were no adjustments other than normal recurring adjustments. These unaudited interim condensed consolidated financial results are not necessarily indicative of the results to be expected for the year ending April 30, 2024, or for any other future annual or interim period. The accompanying unaudited interim condensed consolidated financial statements should be read in conjunction with the audited financial statements as of and for the year ended April 30, 2023 in the Company’s Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”) on July 10, 2023.
|
Segment Reporting |
Segment Reporting: The chief operating decision maker, the CEO, manages the Company’s operations as a single operating segment for the purposes of assessing performance and making operating decisions.
|
Recent Accounting Pronouncements |
Recent Accounting Pronouncements: In June 2016, the FASB issued ASU 2016-13, Financial Instruments-Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments, which amends the impairment model by requiring entities to use a forward-looking approach on expected losses to estimate credit losses on certain financial instruments, including trade receivables and available-for-sale debt securities. This guidance became effective on May 1, 2023 and did not have a material impact to the consolidated financial statements. As the Company has never recorded any other-than-temporary-impairment adjustments to its available-for-sale debt securities prior to the effective date, no transition provisions were applicable to the Company.
|
Net Loss per Share |
Net Loss per Share: Basic net loss per share is computed by dividing the net loss by the weighted average number of common shares outstanding during the period. Diluted net loss per share is computed by dividing net loss by the sum of the weighted average number of common shares and the number of potential dilutive common share equivalents outstanding during the period. Potential dilutive common share equivalents consist of the incremental common shares issuable upon the exercise of share options and awards. Potential dilutive common share equivalents consist of:
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
|
2024 |
|
|
2023 |
|
Stock options and awards |
|
|
6,229,313 |
|
|
|
5,386,625 |
|
The Company uses the treasury stock method to calculate the weighted average shares used in computing diluted net loss per share. In computing diluted earnings per share, common share equivalents are not considered in periods in which a net loss is reported, as the inclusion of the common share equivalents would be anti-dilutive. As a result, there is no difference between the Company’s basic and diluted loss per share for the periods presented. The weighted average number of common shares used in the basic and diluted net loss per common share calculations includes the weighted-average pre-funded warrants outstanding during the period as they are exercisable at any time for nominal cash consideration.
|
Fair Value Measurement |
Fair Value Measurement: The Company classifies fair value measurements using a three-level hierarchy that prioritizes the inputs used to measure fair value. This hierarchy requires entities to maximize the use of observable inputs and minimize the use of unobservable inputs. The three levels of inputs used to measure fair value are as follows: Level 1, quoted market prices in active markets for identical assets or liabilities; Level 2, observable inputs other than quoted market prices included in Level 1, such as quoted market prices for markets that are not active or other inputs that are observable or can be corroborated by observable market data; and Level 3, unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities, including certain pricing models, discounted cash flow methodologies and similar techniques that use significant unobservable inputs. These fair values are obtained from independent pricing services which utilize Level 1 and Level 2 inputs. The following tables summarize the cash equivalents and marketable securities measured at fair value on a recurring basis as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
January 31, 2024 |
|
Cash equivalents |
$ |
57 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
57 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
Corporate debt securities |
|
— |
|
|
|
48,339 |
|
|
|
— |
|
|
|
48,339 |
|
U.S. government agency securities |
|
— |
|
|
|
4,191 |
|
|
|
— |
|
|
|
4,191 |
|
|
$ |
57 |
|
|
$ |
52,530 |
|
|
$ |
— |
|
|
$ |
52,587 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
April 30, 2023 |
|
Cash equivalents |
$ |
31,507 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
31,507 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
Corporate debt securities |
|
— |
|
|
|
77,967 |
|
|
|
— |
|
|
|
77,967 |
|
U.S. government agency securities |
|
— |
|
|
|
15,170 |
|
|
|
— |
|
|
|
15,170 |
|
|
$ |
31,507 |
|
|
$ |
93,137 |
|
|
$ |
— |
|
|
$ |
124,644 |
|
|
X |
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v3.24.0.1
Summary of Significant Accounting Policies (Tables)
|
9 Months Ended |
Jan. 31, 2024 |
Accounting Policies [Abstract] |
|
Schedule of Potential Dilutive Common Share Equivalents |
Potential dilutive common share equivalents consist of:
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
|
2024 |
|
|
2023 |
|
Stock options and awards |
|
|
6,229,313 |
|
|
|
5,386,625 |
|
The Company uses the treasury stock method to calculate the weighted average shares used in computing diluted net loss per share.
|
Schedule of Cash Equivalents and Marketable Securities Measured at Fair Value |
The following tables summarize the cash equivalents and marketable securities measured at fair value on a recurring basis as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
January 31, 2024 |
|
Cash equivalents |
$ |
57 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
57 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
Corporate debt securities |
|
— |
|
|
|
48,339 |
|
|
|
— |
|
|
|
48,339 |
|
U.S. government agency securities |
|
— |
|
|
|
4,191 |
|
|
|
— |
|
|
|
4,191 |
|
|
$ |
57 |
|
|
$ |
52,530 |
|
|
$ |
— |
|
|
$ |
52,587 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance at |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
April 30, 2023 |
|
Cash equivalents |
$ |
31,507 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
31,507 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
Corporate debt securities |
|
— |
|
|
|
77,967 |
|
|
|
— |
|
|
|
77,967 |
|
U.S. government agency securities |
|
— |
|
|
|
15,170 |
|
|
|
— |
|
|
|
15,170 |
|
|
$ |
31,507 |
|
|
$ |
93,137 |
|
|
$ |
— |
|
|
$ |
124,644 |
|
|
X |
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v3.24.0.1
Marketable Securities (Tables)
|
9 Months Ended |
Jan. 31, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
Summary of Fair Values of Company's Investments By Type |
The following tables summarize the fair values of the Company’s investments by type as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
January 31, 2024 |
|
|
Amortized |
|
|
Unrealized |
|
|
Unrealized |
|
|
Estimated |
|
|
Cost |
|
|
Gains |
|
|
Losses |
|
|
Fair Value |
|
Corporate debt securities |
$ |
47,827 |
|
|
$ |
525 |
|
|
$ |
(13 |
) |
|
$ |
48,339 |
|
Obligations of the U.S. Government and its agencies |
|
4,178 |
|
|
|
13 |
|
|
|
— |
|
|
|
4,191 |
|
Total |
$ |
52,005 |
|
|
$ |
538 |
|
|
$ |
(13 |
) |
|
$ |
52,530 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
April 30, 2023 |
|
|
Amortized |
|
|
Unrealized |
|
|
Unrealized |
|
|
Estimated |
|
|
Cost |
|
|
Gains |
|
|
Losses |
|
|
Fair Value |
|
Corporate debt securities |
$ |
77,768 |
|
|
$ |
367 |
|
|
$ |
(168 |
) |
|
$ |
77,967 |
|
Obligations of the U.S. Government and its agencies |
|
15,094 |
|
|
|
76 |
|
|
|
|
|
|
15,170 |
|
Total |
$ |
92,862 |
|
|
$ |
443 |
|
|
$ |
(168 |
) |
|
$ |
93,137 |
|
|
Summary of Scheduled Maturity for Marketable Securities |
The following table summarizes the scheduled maturity for the Company’s marketable securities at January 31, 2024 (in thousands):
|
|
|
|
|
January 31, 2024 |
|
Maturing in one year or less |
$ |
30,047 |
|
Maturing after one year through two years |
|
13,516 |
|
Maturing after two years through three years |
|
8,967 |
|
Total |
$ |
52,530 |
|
|
X |
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v3.24.0.1
Accrued Expenses (Tables)
|
9 Months Ended |
Jan. 31, 2024 |
Payables and Accruals [Abstract] |
|
Schedule of Accrued Expenses |
Accrued expenses consisted of the following as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
April 30, |
|
|
|
2024 |
|
|
2023 |
|
Accrued compensation |
|
$ |
5,465 |
|
|
$ |
4,207 |
|
Accrued research expense |
|
|
7,993 |
|
|
|
3,817 |
|
Accrued professional fees |
|
|
1,247 |
|
|
|
906 |
|
Other accrued expenses |
|
|
135 |
|
|
|
198 |
|
|
|
$ |
14,840 |
|
|
$ |
9,128 |
|
|
X |
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v3.24.0.1
Prepaid Expenses and Other Current Assets (Tables)
|
9 Months Ended |
Jan. 31, 2024 |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] |
|
Schedule of Prepaid Expenses and Other Current Assets |
Prepaid expenses and other current assets consisted of the following as of January 31, 2024 and April 30, 2023 (in thousands):
|
|
|
|
|
|
|
|
|
|
|
January 31, |
|
|
April 30, |
|
|
|
2024 |
|
|
2023 |
|
Prepaid preclinical and clinical activities |
|
$ |
1,871 |
|
|
$ |
1,724 |
|
Other prepaid expenses |
|
|
2,964 |
|
|
|
2,583 |
|
Interest and other receivables |
|
|
408 |
|
|
|
654 |
|
VAT receivable |
|
|
263 |
|
|
|
1,422 |
|
Total prepaid expenses and other current assets |
|
$ |
5,506 |
|
|
$ |
6,383 |
|
|
X |
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v3.24.0.1
Leases (Tables)
|
9 Months Ended |
Jan. 31, 2024 |
Leases [Abstract] |
|
Summary of Maturity of Undiscounted Payments and Future Minimum Payments Due Under Lease Liabilities and Present Value of Liabilities |
The following table summarizes the maturity of undiscounted payments due under lease liabilities and the present value of those liabilities as of January 31, 2024 (in thousands):
|
|
|
|
|
Years ending April 30, |
|
Operating Leases |
|
2024 |
|
$ |
438 |
|
2025 |
|
|
1,775 |
|
2026 |
|
|
1,813 |
|
2027 |
|
|
1,851 |
|
2028 |
|
|
1,847 |
|
Thereafter |
|
|
1,537 |
|
Total minimum lease payments |
|
|
9,261 |
|
Less amounts representing interest |
|
|
1,817 |
|
Present value of minimum payments |
|
|
7,444 |
|
Current portion |
|
|
1,187 |
|
Long-term portion |
|
$ |
6,257 |
|
|
X |
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v3.24.0.1
The Company - Additional Information (Detail) $ / shares in Units, $ in Thousands |
|
1 Months Ended |
|
|
Feb. 14, 2024
USD ($)
$ / shares
shares
|
Feb. 29, 2024
Country
Site
Partcipant
|
Jan. 31, 2024
USD ($)
|
Apr. 30, 2023
USD ($)
|
Accumulated deficit |
|
|
$ 425,077
|
$ 343,082
|
Cash, cash equivalents and marketable securities |
|
|
$ 75,600
|
|
Subsequent Event [Member] |
|
|
|
|
Number of participants | Partcipant |
|
136
|
|
|
Number of sites | Site |
|
66
|
|
|
Number of countries | Country |
|
20
|
|
|
Net proceeds from offering, after deducting estimated expenses |
$ 150,100
|
|
|
|
Pre-funded Warrants [Member] | Subsequent Event [Member] |
|
|
|
|
Price per share under underwriting agreement | $ / shares |
$ 15.249
|
|
|
|
Pre-funded Warrants [Member] | Maximum [Member] | Subsequent Event [Member] |
|
|
|
|
Warrants to purchase shares of common stock | shares |
3,483,688
|
|
|
|
Common Stock [Member] | Subsequent Event [Member] |
|
|
|
|
Aggregate number of shares to sell under underwriting agreements | shares |
7,016,312
|
|
|
|
Price per share under underwriting agreement | $ / shares |
$ 15.25
|
|
|
|
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v3.24.0.1
Summary of Significant Accounting Policies - Schedule of Cash Equivalents and Marketable Securities Measured at Fair Value (Detail) - USD ($) $ in Thousands |
Jan. 31, 2024 |
Apr. 30, 2023 |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
$ 57
|
$ 31,507
|
Marketable securities |
52,530
|
93,137
|
Cash equivalents and marketable securities |
52,587
|
124,644
|
Level 1 [Member] |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
57
|
31,507
|
Cash equivalents and marketable securities |
57
|
31,507
|
Level 2 [Member] |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents and marketable securities |
52,530
|
93,137
|
Corporate Debt Securities [Member] |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Marketable securities |
48,339
|
77,967
|
Corporate Debt Securities [Member] | Level 2 [Member] |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Marketable securities |
48,339
|
77,967
|
U.S. Government Agency Securities [Member] |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Marketable securities |
4,191
|
15,170
|
U.S. Government Agency Securities [Member] | Level 2 [Member] |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Marketable securities |
$ 4,191
|
$ 15,170
|
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v3.24.0.1
Marketable Securities - Summary of Fair Values of Company's Investments By Type (Detail) - USD ($) $ in Thousands |
Jan. 31, 2024 |
Apr. 30, 2023 |
Marketable Securities [Line Items] |
|
|
Amortized Cost |
$ 52,005
|
$ 92,862
|
Unrealized Gains |
538
|
443
|
Unrealized Losses |
(13)
|
(168)
|
Estimated Fair Value |
52,530
|
93,137
|
Corporate Debt Securities [Member] |
|
|
Marketable Securities [Line Items] |
|
|
Amortized Cost |
47,827
|
77,768
|
Unrealized Gains |
525
|
367
|
Unrealized Losses |
(13)
|
(168)
|
Estimated Fair Value |
48,339
|
77,967
|
Obligations of U.S. Government and Its Agencies [Member] |
|
|
Marketable Securities [Line Items] |
|
|
Amortized Cost |
4,178
|
15,094
|
Unrealized Gains |
13
|
76
|
Estimated Fair Value |
$ 4,191
|
$ 15,170
|
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v3.24.0.1
Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Details) - USD ($) $ in Thousands |
Jan. 31, 2024 |
Apr. 30, 2023 |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] |
|
|
Prepaid preclinical and clinical activities |
$ 1,871
|
$ 1,724
|
Other prepaid expenses |
2,964
|
2,583
|
Interest and other receivables |
408
|
654
|
VAT receivable |
263
|
1,422
|
Total prepaid expenses and other current assets |
$ 5,506
|
$ 6,383
|
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v3.24.0.1
Leases - Summary of Maturity of Undiscounted Payments Due Under Lease Liabilities and Present Value of Liabilities (Detail) - USD ($) $ in Thousands |
Jan. 31, 2024 |
Apr. 30, 2023 |
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract] |
|
|
2024 |
$ 438
|
|
2025 |
1,775
|
|
2026 |
1,813
|
|
2027 |
1,851
|
|
2028 |
1,847
|
|
Thereafter |
1,537
|
|
Total minimum lease payments |
9,261
|
|
Less amounts representing interest |
1,817
|
|
Present value of minimum payments |
7,444
|
|
Current portion |
1,187
|
$ 1,087
|
Long-term portion |
$ 6,257
|
$ 7,145
|
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v3.24.0.1
Subsequent Event - Additional Information (Detail) - Subsequent Event [Member] - USD ($)
|
|
|
|
1 Months Ended |
Feb. 17, 2024 |
Feb. 14, 2024 |
Feb. 11, 2024 |
Feb. 29, 2024 |
Subsequent Event [Line Items] |
|
|
|
|
Aggregate offering of common shares authorized |
|
0
|
|
|
Net proceeds from offering, after deducting estimated expenses |
|
$ 150,100,000
|
|
|
Performance-based Restricted Stock Units [Member] |
|
|
|
|
Subsequent Event [Line Items] |
|
|
|
|
Number of shares granted |
76,667
|
|
360,000
|
|
Performance-based Restricted Stock Units [Member] | January 2024 Grants [Member] |
|
|
|
|
Subsequent Event [Line Items] |
|
|
|
|
Grant date fair value |
|
|
|
$ 12.71
|
Performance-based Restricted Stock Units [Member] | March 2022 Grants [Member] |
|
|
|
|
Subsequent Event [Line Items] |
|
|
|
|
Grant date fair value |
|
|
|
$ 15.39
|
Maximum [Member] |
|
|
|
|
Subsequent Event [Line Items] |
|
|
|
|
Aggregate offering price of common stock authorized |
|
$ 100,000,000
|
|
|
Common Stock [Member] |
|
|
|
|
Subsequent Event [Line Items] |
|
|
|
|
Aggregate number of shares to sell under underwriting agreements |
|
7,016,312
|
|
|
Price per share under underwriting agreement |
|
$ 15.25
|
|
|
Pre-funded Warrants [Member] |
|
|
|
|
Subsequent Event [Line Items] |
|
|
|
|
Price per share under underwriting agreement |
|
$ 15.249
|
|
|
Pre-funded Warrants [Member] | Maximum [Member] |
|
|
|
|
Subsequent Event [Line Items] |
|
|
|
|
Warrants to purchase shares of common stock |
|
3,483,688
|
|
|
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