jondoeuk
2 months ago
They now have the ability to put in eight to nine edits. So it is a single cassette that expresses the CAR, can express a cytokine and has an shRNA-like approach to knock down genes. So there's no theoretical limit as to the number of edits, but there may be marginal utility beyond a certain point.
Hopefully, they look to improve donor selection, cell selection and manufacturing, as all could increase efficacy.