RNS Number:6436I
Skyepharma PLC
12 March 2003


For Immediate Release                                              12 March 2003


                         SkyePharma plc (the "Company")

                    Notification of Major Interest in Shares


In accordance with Part VI of the Companies Act 1985 (as amended) the Company
was informed on 11 March 2003 that on 10 March 2003 Standard Life Investments,
on behalf of the Standard Life Group, purchased 259,017 SkyePharma plc Ordinary
Shares, thus increasing their holding to 18,476,363 Ordinary Shares,
representing 3.011% of the issued share capital of the Company.  These Ordinary
Shares are registered in the name of Stanlife Nominees Limited.


                                    - Ends -


                      This information is provided by RNS
            The company news service from the London Stock Exchange
END
HOLZLLFFXXBLBBQ