By Eyk Henning and Alexandra Edinger

U.S. mortgage lender Wells Fargo (WFC) and financial investor Lone Star are in exclusive talks to buy a U.K. commercial property loan portfolio worth more than 4 billion pounds from Germany's Commerzbank AG (CBK.XE), two people familiar with the matter said Thursday.

Lone Star and Commerzbank declined to comment. Wells Fargo wasn't immediately available for a comment.

Commerzbank put the portfolio up for sale as it seeks to free up equity to strengthen its capital ratio. Germany's second-largest lender by balance-sheet volume is under pressure to strengthen its capital base amid tougher regulation and eroding earnings. In mid-March, the bank announced a EUR2.5 billion capital increase, as it looks to bolster its balance sheet and take another bold step to reduce government involvement in the bank.

The bank will hold its general annual meeting in Frankfurt Friday.

Wells Fargo and Lone Star, which teamed up to buy the portfolio, are close to buying the asset, two people familiar with the matter said, adding that the sale would come at a slight discount to the book value of the assets.

While Wells Fargo would buy the performing loans, Lone Star would snap up the non-performing and distressed loans, these people say.

According to a Commerzbank presentation from mid-March, the U.K. real-estate portfolio has EUR5.2 billion of performing and EUR1.3 billion of non-performing loans. It is unclear if the buyers will take up all of the assets, however.

Other suitors not accepted for the final round included a bidding tandem consisting of the world's biggest bond fund Pimco and financial investor Cerberus.

U.K.-based real estate is receiving fresh interest from U.S. investors at the moment because properties in other European countries bear a certain currency risk due to the euro-zone crisis, bankers say.

While the volume of European real-estate acquisitions dropped by more than a third by the end of March year to date, the U.K. bucked the overall trend with volume doubling year-on-year to $5.8 billion, according to data provider and research firm dealogic.

The Financial Times earlier reported that Commerzbank is close to selling its U.K. portfolio.

Write to Eyk Henning at eyk.henning@wsj.com and Alexandra Edinger at alexandra.edinger@wsj.com

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