Arch Biopartners Hires d3 Medicine to Develop a Human Trial for Brain Tumor Targeting Technology
May 29 2014 - 10:04AM
Marketwired
Arch Biopartners Hires d3 Medicine to Develop a Human Trial for
Brain Tumor Targeting Technology
TORONTO, ONTARIO--(Marketwired - May 29, 2014) - Arch
Biopartners Inc (Arch) or (the Company) (CSE:ACH)(OTCBB:FOIFF)
announced today it has hired d3 Medicine to work as the Company's
new drug development team.
d3's first task will be to design a Phase I/II human trial for
MetaMx, the Company's brain tumour targeting technology, in
patients with malignant glioma.
"The engagement of d3 Medicine instantly brings to Arch a
multifunctional team experienced in toxicology, clinical
pharmacology, regulatory affairs and business development," said
Richard Muruve, CEO of Arch.
Arch intends to perform this human trial to characterize the
safety and pharmacokinetics of MetaMx and to demonstrate the
efficacy of MetaMx to cross the human blood brain barrier and
detect brain tumor initiating cells (BTICs) and invasive glioma
cells. Such results in human patients will increase the value of
MetaMx not only as a diagnostic and imaging tool but also as a
potential drug delivery platform to destroy BTICs and invasive
glioma cells.
d3 Medicine will deliver a detailed clinical development plan up
to and including the key elements of the first human trial:
Chemistry, Manufacturing and Controls (CMC), regulatory strategy
and toxicology.
Leading the d3 team is Dr. Patrick Smith, D3's Chief Science
Officer and former head of US Clinical Pharmacology for Roche. Dr.
Michael Taylor, Founder and Principal at NonClinical Safety
Assessment, will be responsible for planning the toxicology needs
of MetaMx.
Dr. Krishnan Viswanadhan, will have the Regulatory Lead for
MetaMx. Dr. Viswanadhan is Vice President of Advyzom, a leading
regulatory affairs boutique consulting company.
Craig Rayner, D3's CEO and a former Global Due Diligence leader
at Roche, will oversee due diligence, peer review and provide
valuable drug development experience. Joining Dr. Rayner in this
regard is Dr. Regina Dutkowski whose past appointments include
Global Development Team Leader, Roche.
Dr. Vis Niranjan, d3's Chief Medical Officer, is a U.S. licensed
physician-scientist with many years of broad drug development
experience. Dr. Niranjan will provide in depth clinical experience
to the development of MetaMx and the preparation of the first human
study.
About Malignant Glioma and MetaMx
Worldwide, there are approximately 70,000 new patients with
malignant glioma each year and clinical outcomes for these patients
have not changed substantially over the past 30 years. Average
survival rates remain at a dismal 12-15 months and long term
survivors (i.e. those surviving more than 3 years) are rare.
This poor survival rate is linked to brain tumour initiating
cells (BTICs) and invasive glioma cells which represent disease
reservoirs that are not detectable using current diagnostic
techniques as they are indiscernible from normal tissue. As a
result, these cells are usually left behind in brain tissue post
surgery and often lead to tumour relapse and poor patient
outcomes.
Therefore, a significant unmet medical need and commercial
opportunity is the ability to target BTICs and invasive glioma
cells for the purpose of imaging, diagnosing and developing
targeted therapies to improve patient outcomes and survival
rates.
MetaMx is comprised of proprietary molecules that target both
BTICs and invasive glioma cells. The lead inventors of MetaMx are
Dr. Stephen Robbins, Dr. Donna Senger and Dr. Jennifer Rahn at the
University of Calgary.
About D3 Medicine
d3 Medicine (www.d3medicine.com) was created to provide the
biopharmaceutical industry, non-profit sector, and government
agencies with access to a team of contemporary drug development
experts. With a strong track record of delivering genuine
commercial and therapeutic impact, d3's team members are globally
recognized as industry leaders. d3 consists of experienced
executives supported by an agile global network of experts with
aligned values, providing state of the art integrated perspectives
effectively and efficiently.
For full biographies of the d3 team members above please visit:
http://www.d3medicine.com/who-we-are/leadership
About Arch Biopartners
Arch Biopartners is a portfolio based biotechnology company
established to develop new products and technology for sale to
pharmaceutical and industrial companies. The Company's website
address is: www.archbiopartners.com.
For more information on the Company, please consult the other
public documents filed on SEDAR at www.sedar.com.
Forward-Looking Statements
All statements, other than statements of historical fact, in
this news release are forward looking statements that involve
various risks and uncertainties, including, without limitation,
statements regarding the future plans and objectives of the
Company. There can be no assurance that such statements will prove
to be accurate. Actual results and future events could differ
materially from those anticipated in such statements. These and all
subsequent written and oral forward-looking statements are based on
the estimates and opinions of management on the dates they are made
and are expressly qualified in their entirety by this notice. The
Company assumes no obligation to update forward-looking statements
should circumstances or management's estimates or opinions
change.
The CSE has not
reviewed and does not accept responsibility for the adequacy of
this release.
Arch Biopartners Inc.(647) 428
7031info@archbiopartners.comwww.archbiopartners.com
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