Gene Logic and Organon Enter Collaboration to Find New Therapeutic Applications for Clinical Drug Candidates
April 21 2006 - 7:05AM
Business Wire
Gene Logic Inc. (NASDAQ:GLGC) and Organon announced today that they
have entered into a drug repositioning agreement to seek
alternative development paths for multiple drug candidates of which
Organon has previously discontinued clinical development. Under the
terms of the agreement, Gene Logic will seek new therapeutic uses
for Organon compounds. Upon discovery of potential new therapeutic
utility, both companies will become equal owners and may decide to
jointly develop and commercialize the drug candidate. Gene Logic
will receive a success-based milestone payment for each therapeutic
candidate that Organon chooses to enter into clinical development.
Gene Logic's Drug Repositioning Program seeks to find alternative
development paths for drug candidates with good safety records that
have been deprioritized or discontinued in Phase II or Phase III
clinical trials. The program offers pharmaceutical partners a novel
approach to bolster their late-stage pipelines with safe,
high-quality drug candidates that originated from their own R&D
efforts. Applying a diverse set of drug discovery technologies in
parallel, Gene Logic's Drug Repositioning Program evaluates drug
candidates for potential utility across a wide spectrum of disease
indications. David Nicholson, Executive Vice President of Global
Research & Development at Organon said, "We believe Gene
Logic's program has the potential to find new value in our
previously deprioritized drug candidates. Organon continues to seek
new technologies to increase our drug research output. This
technology is an opportunity to address that." Louis Tartaglia,
Ph.D., General Manager and Senior Vice President of Drug
Repositioning for Gene Logic, said, "We believe that this agreement
with Organon--part of a long history of productive relationships
between the two companies--represents a significant opportunity for
both parties. Gene Logic's Drug Repositioning Program is designed
to provide a comprehensive picture of the drug candidates'
biological activities and determine if there are new therapeutic
uses for these potential medicines. Finding new therapeutic uses
for deprioritized drug candidates of Organon would benefit both
companies and bring new medicines to patients." Gene Logic Overview
Gene Logic is leading the transformation of pharmaceutical research
and development with its extensive gene expression databases,
pioneering efforts in toxicogenomics, sophisticated bioinformatics
expertise, specialty nonclinical services testing capabilities and
cutting edge technology program for drug repositioning. Gene Logic
technologies and services are used by many of the world's top
pharmaceutical and biotechnology companies. Over 150 organizations
and government agencies have benefited from Gene Logic's diverse
portfolio of drug development services, enabling them to make more
informed, more reliable and more predictive decisions at each point
in the highly complex and costly drug development process. Gene
Logic currently has drug repositioning agreements with Pfizer,
Roche, and Millennium Pharmaceuticals. Founded in 1994, Gene Logic
is headquartered in Gaithersburg, Md., with additional research and
development facilities in Cambridge, Mass. and Berkeley, Calif. The
Company maintains customer support operations in Europe and Asia
and currently has about 450 employees worldwide. For more
information, visit www.genelogic.com or call toll-free -
1/800/GENELOGIC. Organon Overview Organon - with shared head
offices in Roseland, NJ, USA and Oss, The Netherlands - creates,
manufactures and markets innovative prescription medicines that
improve the health and quality of human life. Through a combination
of independent growth and business partnerships, Organon strives to
remain or become one of the leading biopharmaceutical companies in
each of its core therapeutic fields: fertility, gynecology,
anesthesia and neuroscience. Research areas also include immunology
and oncology. Organon products are sold in over 100 countries, of
which more than 60 have an Organon subsidiary. Organon is the human
health care business unit of Akzo Nobel. Safe Harbor Statement*
This press release may contain statements which address such key
issues as Organon's growth strategy, future financial results,
market positions, product development, pharmaceutical products in
the pipeline, and product approvals. Such statements should be
carefully considered, and it should be understood that many factors
could cause forecasted and actual results to differ from these
statements. These factors include, but are not limited to, price
fluctuations, currency fluctuations, progress of drug development,
clinical testing and regulatory approval, developments in raw
material and personnel costs, pensions, physical and environmental
risks, legal issues, and legislative, fiscal, and other regulatory
measures. Stated competitive positions are based on management
estimates supported by information provided by specialized external
agencies. For a more comprehensive discussion of the risk factors
affecting our business please see our Annual Report on Form 20-F
filed with the United States Securities and Exchange Commission, a
copy of which can be found on the Akzo Nobel corporate website
www.akzonobel.com. The 2005 Annual Report on Form 20-F will be
available at the end of the second quarter of 2006. * Pursuant to
the U.S. Private Securities Litigation Reform Act 1995.
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