FORM 4
☐ Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

MAETZOLD DEREK J		 2. Issuer Name and Ticker or Trading Symbol

CASTLE BIOSCIENCES INC [ CSTL ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Pres. & Chief Exec. Officer
(Last)          (First)          (Middle)

C/O CASTLE BIOSCIENCES, INC., 505 S. FRIENDSWOOD DRIVE, SUITE 401		 3. Date of Earliest Transaction (MM/DD/YYYY)

5/15/2023
(Street)

FRIENDSWOOD, TX 77546		 4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)        (State)        (Zip)
Rule 10b5-1(c) Transaction Indication
☐ Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 5/15/2023  S(1)  1538 D$23.447 (2)150443 D  
Common Stock 5/15/2023  S(1)  769 D$23.447 (2)112785 I By The Maetzold Descendants 2020 Trust (3)
Common Stock 5/15/2023  S(1)  769 D$23.447 (2)101680 I By Derek Maetzold 2020 Irrevocable Trust (4)
Common Stock 5/15/2023  S(1)  384 D$23.447 (2)19834 I By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk (5)
Common Stock 5/15/2023  S(1)  384 D$23.447 (2)19834 I By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold (6)
Common Stock 5/15/2023  S(1)  384 D$23.447 (2)19834 I By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold (7)
Common Stock 5/15/2023  S(1)  384 D$23.447 (2)19828 I By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold (8)
Common Stock 5/16/2023  S(1)  1254 D$22.82 (9)149189 D  
Common Stock 5/16/2023  S(1)  627 D$22.82 (9)112158 I By The Maetzold Descendants 2020 Trust (3)
Common Stock 5/16/2023  S(1)  627 D$22.82 (9)101053 I By Derek Maetzold 2020 Irrevocable Trust (4)
Common Stock 5/16/2023  S(1)  313 D$22.82 (9)19521 I By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk (5)
Common Stock 5/16/2023  S(1)  313 D$22.82 (9)19521 I By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold (6)
Common Stock 5/16/2023  S(1)  313 D$22.82 (9)19521 I By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold (7)
Common Stock 5/16/2023  S(1)  313 D$22.82 (9)19515 I By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold (8)
Common Stock         130000 I By DJM Grantor Retained Annuity Trust No. 4 (10)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
(1) These transactions were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person, The Maetzold Descendants 2020 Trust, Derek Maetzold 2020 Irrevocable Trust, The Maetzold 2018 Remainder Trust f/b/o Emily Carol Kirk, The Maetzold 2018 Remainder Trust f/b/o Hannah Elizabeth Maetzold, The Maetzold 2018 Remainder Trust f/b/o John Derek Maetzold, and The Maetzold 2018 Remainder Trust f/b/o Peter Douglas Maetzold on December 12, 2022.
(2) This transaction was executed in multiple trades at prices ranging from $22.830 to $23.620, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(3) Held by The Maetzold Descendants 2020 Trust of which the Reporting Person's spouse is the trustee and the Reporting Person's spouse and their children are beneficiaries.
(4) Held by Derek Maetzold 2020 Irrevocable Trust of which the Reporting Person is the trustee and his children are beneficiaries.
(5) Held by The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk of which the Reporting Person is the trustee and his child is the beneficiary.
(6) Held by The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
(7) Held by The Maetzold 2018 Remainder Trust FBO John Derek Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
(8) Held by The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
(9) This transaction was executed in multiple trades at prices ranging from $22.650 to $23.215, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(10) Held by DJM Grantor Retained Annuity Trust No. 4 of which the Reporting Person is the trustee and beneficiary.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
MAETZOLD DEREK J
C/O CASTLE BIOSCIENCES, INC.
505 S. FRIENDSWOOD DRIVE, SUITE 401
FRIENDSWOOD, TX 77546		X
Pres. & Chief Exec. Officer
Signatures
/s/ Greg Acosta, Attorney-in-fact5/17/2023
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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