starbuxsux
4 years ago
ASLAN Pharmaceuticals reports positive data from three dose cohorts for study of ASLAN004 for the treatment of moderate to severe atopic dermatitis
6:09 AM ET 3/1/21 | Briefing.com
Co announces positive interim unblinded data from the three dose cohorts of its ongoing randomised, double-blind placebo controlled multiple ascending dose study of ASLAN004 for the treatment of moderate to severe atopic dermatitis. ASLAN004 was shown to be well tolerated across all doses and showed improvements compared to placebo in all efficacy endpoints, supporting its potential as a differentiated, novel treatment for AD.The Phase 1 study evaluated three doses of ASLAN004 (200mg, 400mg and 600mg) delivered subcutaneously and is now recruiting a fourth (expansion) cohort (600mg).The average baseline Eczema Area Severity Index score of patients was 32.5 and the average Investigators Global Assessment score was 3.4.At week 8, the average reduction in EASI from baseline at therapeutic doses (400mg and 600mg cohorts) was 74% compared to 42% for patients on placebo.Peak pruritus improved after just one dose and continued to improve by an average of 46% relative to baseline at 8 weeks compared to 16% for patients on placebo.
keekee
5 years ago
How about putting some Market Manipulators in jail...MMs in jail??? Would be fantastic!!!
Manipulative conduct is often divided into two categories: โTraditional Manipulationโ and โOpen Market Manipulation.โ Traditional manipulation requires a โbad actโ explicitly proscribed under Section 9(a)(1) of the Exchange Act, such as fictitious trading, a โpump and dumpโ scheme, or wash sales. Under Rule 10b-5, the fraudulent conduct alone is indicative of the manipulatorโs deceptive intent. In open market manipulation, the trades themselves are not objectively fraudulent but, when taken in context, may constitute a manipulative practice. An example is โpainting the tape,โ or โmarking the close,โ which involve engaging in a series of transactions on a public facility, typically at the end of a trading day, in order to give the impression of activity or price movement in a security. Each transaction may individually appear legitimate, making the manipulatorโs intent in the overall open market scheme more difficult to prove.
Enforcement agencies have sought to target market manipulation as far back as 1934 when the Exchange Act was enacted.