XenaLives
5 months ago
I stumbled upon this when researching taurine supplementation...
Sodium phenylbutyrate is a white or yellow powder which decomposes at about 220°C. It is freely soluble in water and
methanol; sparingly soluble in ethanol; and practically insoluble in methylene chloride, acetone, and diethyl ether.
Taurursodiol, also known as tauroursdeoxycholic acid, is an ambiphilic bile acid and is the taurine conjugate of ursodiol, also
known as ursodeoxycholic acid. The chemical name of taurursodiol is 2-[(3a, 7ß-dihydroxy-24-oxo-5ß-cholan-24-yl) amino]
ethane sulfonic acid, dihydrate. The molecular formula is C26H45NO6S . 2H2O and the molecular weight is 535.74
(dihydrate).
The taurursodiol chemical structure is:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/216660s000lbledt.pdf
The reason I was researching taurine is I have been taking it as a supplement for a year or more, but just discovered that I was taking a sub therapeutic dose. I altered the dosage to 3g plus and within 48 hours a tremor (most likely due to flouroquinolone poisoning) was controlled.
From Google AI:
Taurine conjugated bile acids (BAs) are cholesterol derivatives that are conjugated with taurine in the liver. Taurine is the body's most abundant free amino acid, and it plays a role in many essential functions, including development, energy production, and inflammation. BAs have antimicrobial properties that help prevent microbial colonization in the GI tract.
NCBI
Versatile Triad Alliance: Bile Acid, Taurine and Microbiota - PMC
Jul 29, 2022
MTHFR Support Australia
Taurine and Its Role in Bile Synthesis
Jul 28, 2017 — Bile acids and conjugation with taurine. As bile acids are conjugated with taurine in the liver, there are several modifications that occur in hepatocytes that are vital to ensure the liver remains in a healthy state. For instance, membrane mobility, and overall fluidity of hepatocytes, increase in the presence of bile acids conjugated with taurine. Therefore, bile acids are frequently found conjugated with taurine – enabling advanced hepatocyte efficiency. Bile acid conjugation with taurine or glycine is catalyzed by two biochemical reactions: The enzyme cholyl-CoA synthetase catalyzes bile acid into acyl-CoA thioester.
Conjugation of bile acids with taurine promotes bile excretion by increasing their water solubility into bile. This facilitates the absorption of lipids and lipid-soluble vitamins. The conjugation process also makes BAs impermeable to cell membranes, allowing high concentrations to persist in bile and intestinal content.
The liver also produces taurine, and the microbiota regulates BA generation and metabolism. The rate-limiting enzymes in both taurine synthesis and BA conjugation may be regulated by a nucleus receptor, FXR, that promotes BA homeostasis.
The ratio of glycine to taurine conjugation can vary considerably. For example, in cats, BAs in the bile are exclusively conjugated with taurine. In contrast, other primates, rodents, and other Laurasiatheria exclusively conjugate bile acids with taurine but not glycine.
https://www.google.com/search?q=taurine+conjugated+bile+acids&rlz=1C1ONGR_enUS1087US1087
From the replied to post:
Relyvrio treatment a year costs 159K$ per patient.
The above text makes me wonder if this wasn't one big corporate con...
Just bumping up taurine to 3g per day has given me 80% relief from essential tremor in
Scarface
7 months ago
Amylyx is worried about a company, PHA LLC, trademark holders and intellectual property holder in the United States and the European Union for the Motor Neuron/ALS/LOU GERIG DISEASE. For the Ji Wu Li treatment, beginning in January started shipping Worldwide along with signing significant supply contracts with Neurologists around the world. I was told they were involved with the National Institute of Health published paper, Dr. Sven Schroder from Hamburg, Germany on how Ji Wu Li treatment has better results than Relyvrio at a max treatment cost of $1000.00 per month compared to $12,000.00 per month for Relyvrio. Here’s kicker, PHA are looking at several reverse merger targets. If knew the target, there’s money to be made!
MiamiGent
2 years ago
AMLX The Motley Fool
Sun, September 25, 2022 at 9:23 AM
AMLX Three Motley Fool contributors have joined this roundtable to scour the market for some exciting initial public offerings (IPOs) in the healthcare field. Alex Carchidi (Amylyx Pharmaceuticals): Amylyx is worth owning because there's a solid chance it'll soon commercialize the first treatment for amyotrophic lateral sclerosis (ALS) that prolongs survival time while also slowing the disease's progression. Its medicine, AMX0035, has been approved for sale in Canada since late July, and regulators at the U.S. Food and Drug Administration will weigh in on the company's application for commercialization on Sept. 29.This biotech is ready for blastoff
It's also in the final stages of preparing to launch the drug in the European Union, pending the green light from regulators, which could come in the first half of 2023.
Since its IPO in early January of this year, its shares are up by nearly 61.6%, and it'll likely rise even higher. Right now, its revenue is negligible, as there hasn't been an earnings report since the approval of its drug in Canada. But next year, analysts estimate on average that it'll bring in around $174 million if AMX0035 launches in the U.S. as planned, and that'll mean the company's top revenue growth rate should accelerate dramatically.
NASDAQ: AMLX
Amylyx Pharmaceuticals, Inc.
Today's Change
(+3.23%) $0.91
Current Price
$29.09
KEY DATA POINTS
Market Cap
$2B
Day's Range
$27.95 - $29.45
52wk Range
$6.51 - $33.41
Volume
515,343
Avg Vol
1,572,472
Gross Margin
-20475.44%
Dividend Yield
N/A
Furthermore, there aren't any other ALS medicines, so Amylyx will have free rein of the global market, and that could power shareholder returns for years. And, as it already has its foot in the door thanks to its approval in Canada, it isn't as risky as other biotech stocks, though it's still not exactly a great pick for investors with a low risk tolerance.