RNS Number:1865P
Skyepharma PLC
29 August 2003


Immediate Release                                                29 August 2003

                         SkyePharma PLC ("the Company")

As a result of transactions on 29 August 2003 by the SkyePharma PLC Share
Purchase Plan (an Inland Revenue approved all employee share purchase plan),
Michael Ashton and Donald Nicholson, directors of the Company, as trustees of
the Plan, became the beneficial owners of an additional 5,008 Ordinary Shares of
the Company, bringing the total held by the Plan to 77,634 Ordinary Shares of
the Company.

As a result the executive directors of the Company have the following additional
interests as a result of their personal participation in the Plan:-

                    Partnership         Matching          Total number of
                    Shares purchased    Shares awarded    Partnership and
                    on 29 August 2003   on 29 August      Matching Shares held
                    at #0.66            2003 at #0.66     on 29 August 2003
                    per share.          per share.

Ian Gowrie-Smith    190                 190               3,134
Michael Ashton      189                 189               8,562
Donald Nicholson    189                 189               8,562

In accordance with the rules of the Plan these directors have been awarded the
Matching Shares on the basis of one Matching Share for each Partnership Share.

The beneficial ownership of the Matching Shares will pass to the directors in
three years time subject to continued employment and the retention of the
underlying Partnership Shares.



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