RNS Number:0156M
Skyepharma PLC
06 June 2003

Immediate Release                                                   6 June 2003

                         SKYEPHARMA PLC ("the Company")

                     Notification of Interests of Directors

Dr Keith Mansford, a Non-executive Director of SkyePharma PLC, has elected to
invest a proportion of his normal annual fees in SkyePharma PLC Ordinary Shares
and on 5th June 2003 14,953 Ordinary Shares were acquired at a price of 60.25
pence per share. Following the transaction Dr Mansford now has a beneficial
interest in 67,943 Ordinary Shares in the Company.

                                    - ends -


                      This information is provided by RNS
            The company news service from the London Stock Exchange

END
RDSFQLFBXQBFBBL