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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 OR 15(d) of
the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):
August 26, 2024
ARMATA PHARMACEUTICALS, INC.
(Exact name of registrant as specified in
its charter)
Washington |
|
001-37544 |
|
91-1549568 |
(State or other jurisdiction
of incorporation) |
|
(Commission File Number) |
|
(IRS Employer
Identification No.) |
5005 McConnell Avenue, Los Angeles, California |
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90066 |
(Address of principal executive offices) |
|
(Zip Code) |
(310) 655-2928
(Registrant’s telephone number, including area code)
(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
¨ |
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
¨ |
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
¨ |
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
¨ |
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Indicate by check mark whether the registrant is an emerging growth
company as defined in Rule 405 of the Securities Act of 1933 or Rule 12b-2 of the Securities Exchange Act of 1934.
Emerging Growth Company ¨
If an emerging growth company, indicate by check mark if the
registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
provided pursuant to Section 13(a) of the Exchange Act. ¨
Securities registered pursuant to Section 12(b) of
the Act:
Title
of each class |
|
Trading
Symbol(s) |
|
Name
of each exchange on which registered |
Common Stock |
|
ARMP |
|
NYSE American |
Item 7.01 |
Regulation FD Disclosure. |
Included as Exhibit 99.1
to this report is a copy of a poster presentation (the “Poster Presentation”) that Armata Pharmaceuticals, Inc.
(the “Company”) expects to present at the 2024 Military Health System Research Symposium (the “Conference”),
which is being held from August 26 to August 29, 2024, in Kissimmee, Florida. Investors should note that the Poster Presentation
was printed prior to updated figures being available to the Company, and that the 75% figure in the following sentence in the Poster Presentation
has subsequently increased to 80%: “~75% enrolled => Completion projected Q4 2024.”
On August 26,
2024, the Company issued a press release regarding its expected participation in the Conference, a copy of which is attached as Exhibit 99.2
hereto.
The Company posted
an updated corporate presentation dated August 26, 2024 (the “Corporate Presentation”) to its website at https://investor.armatapharma.com/events-and-presentations.
The Corporate Presentation, which is furnished as Exhibit 99.3 hereto, replaces the corporate presentation dated August 16,
2024 previously posted to the Company’s website. The Company plans to use its website to disseminate future updates to the Corporate
Presentation and may not file or furnish a Current Report on Form 8-K alerting investors if the Corporate Presentation is updated.
The information
contained in the Poster Presentation and the Corporate Presentation is summary information that is intended to be considered in the context
of the Company’s Securities and Exchange Commission (“SEC”) filings and other public announcements that the Company
may make, by press release or otherwise, from time to time. The Company undertakes no duty or obligation to publicly update or revise
the information contained in this report, except as may be required by the federal securities laws, although it may do so from time to
time as its management believes is warranted. Any such updating may be made through the filing of other reports or documents with the
SEC, through press releases or through other public disclosure. In addition, the Company disclaims any inferences regarding the materiality
of such information that may arise as a result of it furnishing such information under Item 7.01 of this Current Report on Form 8-K.
The information
in this Item 7.01 and the attached Exhibits 99.1, 99.2, and 99.3 is being furnished and shall not be deemed “filed” for the
purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section.
The information in this Item 7.01 and the attached Exhibits 99.1, 99.2, and 99.3 shall not be incorporated by reference into any registration
statement or other document pursuant to the Securities Act of 1933, as amended.
Item 9.01. Financial Statements and Exhibits.
SIGNATURES
Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
Date: August 26, 2024 |
Armata Pharmaceuticals, Inc. |
|
|
|
By: |
/s/ David D. House |
|
Name: |
David D. House |
|
Title: |
Senior Vice President, Finance and Principal Financial Officer |
Exhibit 99.1
![GRAPHIC](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-1img001.jpg)
| Phase 2 Clinical Trials Evaluating Multi-phage Candidates for the Treatment of Adults with Bacteremia due to Staphylococcus
aureus (diSArm) and Chronic Respiratory Infections due to Pseudomonas aeruginosa (SWARM-P.a. & Tailwind)
Mina Pastagia, MD, Stacey Kolar, PhD, Pierre Kyme, PhD, Thomas Feinberg, MS, Deborah Birx, MD
Armata Pharmaceuticals, Inc., Los Angeles, California
INTRODUCTION
METHODS
RESULTS*
Novel therapeutics such as bacteriophage may be of clinical benefit in
the treatment of challenging infections and respond to the need to
combat antimicrobial resistance (AMR). Phages boast several potential
advantages over conventional broad-spectrum antibiotics. As
bactericidal agents with a narrow spectrum of activity, phages exert
minimal disruption to normal flora, thereby exhibiting inherently
lower toxicity profiles. Their efficacy extends to both antibiotic-sensitive and -resistant bacteria, rendering phage activity independent
of prevailing antibiotic resistance patterns. Furthermore, phages
demonstrate efficacy in disrupting bacterial biofilms, a feat poorly
accomplished by antibiotics. Although phage therapy has enjoyed
widespread utilization and success in human medicine, often serving
as a last-resort salvage therapy, its safety and efficacy await conclusive
validation through randomized, placebo-controlled clinical trials.1-3
Armata’s goal with the support of the U.S. Department of Defense is
to prove the role of phage therapy through definitive pivotal trials
addressing:
• Phage therapy as an alternative or augmentation to antibiotics to
prevent or delay resistance
• Evidence that phage is non-inferior to standard-of-care antibiotics
Advantages of phage therapy:
• Targeted therapy while preserving the microbiome resulting in
decreased patient morbidity
• Ability to constantly update the phage cocktail based on evolution
of bacteria at the population level
• Antibiotic use eliminated or decreased
OBJECTIVES
1. Administration of high doses of intravenous and inhaled phage for
multiple days is well-tolerated in human clinical trial subjects
2. Systemic and local phage remain active in the blood and lungs,
respectively when administered to human clinical trial subjects
3. Inhaled phage monotherapy may have similar bacterial load
reduction as compared with antibiotics in human trial subjects
diSArm is a Phase 1b/2a, placebo-controlled, multiple ascending
dose escalation study of intravenous AP-SA02 as an adjunct to best available
antibiotic therapy (BAT) compared to BAT alone. The trial has evaluated the
safety and tolerability of AP-SA02 via IV bolus infusion every 6 hours for a
period of 5 days in addition to BAT at 2 dose levels: 2 × 10⁹ PFU (Ph1b, Cohort
1) and 2 x 10¹⁰ PFU (Phase 1b, Cohort 2). The trial is actively enrolling subjects
with complicated Staphylococcus aureus (S. aureus) bacteremia.
Subjects in diSArm Phase 1b were dosed at 2 dose levels, for a total of 8 subjects.
The dose was further increased in the enrolling Phase 2a. The study remains
blinded. There have been no deaths or significant AEs precluding dose escalation.
There is retention of phage activity from blood samples collected after dosing.
Detection of phage despite 48 hours of antibiotics is observed in a subgroup of
subjects (~50%), indicating that these subjects may have persistent S. aureus that
the phage are potentially able to find and kill and is evidence of in vivo
amplification.
CONCLUSIONS*
Multiple-dose administration of intravenous AP-SA02 and inhaled AP-PA02 have been well tolerated to date. Early
pharmacokinetic data suggests intravenous AP-SA02 is active in all subjects, with longer phage persistence in a
significant subset of subjects. This may garner increased clinical benefit for patients with difficult to treat S. aureus
infections. Early evidence supports inhaled AP-PA02 monotherapy as a viable alternative to inhaled antibiotics in P.
aeruginosa bronchiectasis. Promising data for both phage candidates is expected to be utilized for planning pivotal
Phase 3 clinical trials in 2025.
REFERENCES
1. Principi N, Silvestri E, Esposito S. Advantages and Limitations of Bacteriophages for the Treatment of Bacterial
Infections. Front Pharmacol. 2019;10:513.
2. Chen Q, Dharmaraj T, Cai PC, et al. Bacteriophage and Bacterial Susceptibility, Resistance, and Tolerance to
Antibiotics. Pharmaceutics. 2022;14(7).
3. Lin DM, Koskella B, Lin HC. Phage therapy: An alternative to antibiotics in the age of multi-drug resistance. World J
Gastrointest Pharmacol Ther. 2017;8(3):162-173.
CONTACT
Armata Pharmaceuticals, Inc.
5005 McConnell Ave, Los Angeles, CA 90066
Tel: +1 (310) 665-2928
Fax: +1 (310) 665-2963
Email: bd@armatapharma.com
diSArm Clinical Trial Data
*Preliminary findings are subject to change pending complete data that will be presented in the future
Early Evidence of AP-SA02 Amplification in Subjects with Active S. aureus Bacteremia
Early Timepoints Post 1st Dose Extended Timepoints Post 1st Dose
Early Timepoints Post 1st Dose Extended Timepoints Post 1st Dose
Subjects with Longer AP-SA02 Persistence in the Blood
Subjects with Shorter AP-SA02 Persistence in the Blood
Patient population: 48 non-cystic fibrosis bronchiectasis subjects across
23 U.S. sites.
Status: Enrollment completed 2024.
Blinded data: Comparable to better P. aeruginosa reduction with AP-PA02
monotherapy compared to AP-PA02 in combination with antibiotics:
topline data available in September 2024.
Patient population: ~50 subjects across ~30 U.S. and Australian sites.
Status: ~75% enrolled => Completion projected Q4 2024.
Early blinded data: AP-SA02 activity and persistence in a subset of subjects.
Supported by: Armata has a $21.6 million Department of Defense grant, received
through the Medical Technology Enterprise Consortium (MTEC) and managed by
the Naval Medical Research Command (NMRC) – Naval Advanced Medical
Development (NAMD) with funding from the Defense Health Agency and Joint
Warfighter Medical Research Program. The grant was awarded to Armata to
support clinical development of its optimized phage candidate, AP-SA02, as a
potential treatment for complicated Staphylococcus aureus bacteremia.
Patient population: 29 cystic fibrosis subjects across 25 U.S. sites.
Status: Completed 2023.
Data Results: Pseudomonas aeruginosa (P. aeruginosa) reduction with
higher AP-PA02 exposures.
Armata is committed to double-blind, placebo-controlled
clinical trials and has completed or is enrolling 3 distinct
Phase 2 trials over the past 2 years
Time
Viable Phage
Concentration
Subject G
Subject H
Subject J
Subject U
Subject V
Subject L
Time
Viable Phage
Concentration
Time
Viable Phage
Concentration
Subject I
Subject N
Subject R
Subject M
Subject P
Time
Viable Phage
Concentration |
Exhibit 99.2
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-2img001.jpg)
Armata Pharmaceuticals Announces Presentation
at the 2024 Military Health System Research Symposium
LOS ANGELES, Calif., August 26, 2024 -- Armata
Pharmaceuticals, Inc. (NYSE American: ARMP) (“Armata” or the “Company”), a biotechnology company focused
on the development of high-purity, pathogen-specific bacteriophage therapeutics for antibiotic-resistant and difficult-to-treat bacterial
infections, today announced that Mina Pastagia, M.D., MS, Chief Medical Officer, will deliver a poster presentation at the 2024 Military
Health System Research Symposium (MHSRS), which is being held August 26-29 in Kissimmee, FL.
The poster provides an overview of Armata’s
two distinct phage development programs, inhaled AP-PA02 (Pseudomonas aeruginosa bronchiectasis) and intravenous AP-SA02 (Staphylococcus
aureus (S. aureus) bacteremia), which are being or have been evaluated in three distinct double-blind, placebo-controlled Phase
2 clinical trials.
Regarding AP-SA02, Armata is currently advancing
its Phase 1b/2a multiple ascending dose study (diSArm) of intravenous AP-SA02 as an adjunct to best available antibiotic therapy (BAT)
compared to BAT alone. Enrollment of the diSArm study is 80% complete, and Armata anticipates completing enrollment by the end of 2024.
The clinical development of AP-SA02 is supported
by a $21.6 million Department of Defense grant, received through the Medical Technology Enterprise Consortium (MTEC) and managed by the
Naval Medical Research Command (NMRC) – Naval Advanced Medical Development (NAMD) with funding from the Defense Health Agency and
Joint Warfighter Medical Research Program.
“We are excited to participate in this year’s
MHSRS and highlight the rigorously designed double-blind, placebo-controlled clinical trials that we are executing for both of our phage
candidates,” stated Dr. Pastagia. “Through our completed and ongoing Phase 2 trials, our phage candidates have been well
tolerated, allowing us to evaluate higher phage doses that can increase the ability of our phages to fulfill their mechanism of action
of attacking only pathogenic bacteria. This in turn is expected to provide Armata with the necessary data to inform how best to administer
phage therapy and decrease the usage of broad-spectrum antibiotics so as to preserve the human microbiome in an effort to lower patient
morbidity. We greatly appreciate the collaborative partnership with the NMRC and NAMD as well as MTEC for its financial support of our
AP-SA02 program. We look forward to advancing both AP-SA02 and AP-PA02 into pivotal Phase 3 trials next year with the hope of introducing
a distinct new class of anti-infectives to patient care.”
Poster presentation details:
Title: | Phase 2 Clinical Trials Evaluating Multi-Phage Candidates for the Treatment of Adults with Bacteremia
due to Staphylococcus aureus (diSArm) and Chronic Respiratory Infections due to Pseudomonas aeruginosa (SWARM-P.a. &
Tailwind) |
| |
Breakout session: | Treating
Refractory Hypoxemia on the Battlefield: What Does the Future Hold? |
| |
Date/time: | Tuesday,
August 27, 10:00 am – 12:00 pm EDT |
Summary:
Multiple-dose administration of intravenous AP-SA02 and inhaled AP-PA02 have been well tolerated to date. Preliminary pharmacokinetic
data suggests intravenous AP-SA02 is active in all subjects, with longer phage persistence in a significant subset of subjects potentially
demonstrating a persistent reservoir of S. aureus bacteria (despite antibiotics) and in vivo amplification of the phages.
This may garner increased clinical benefit for patients with difficult-to-treat S. aureus infections. Preliminary evidence supports
inhaled AP-PA02 monotherapy as a viable alternative to inhaled antibiotics in Pseudomonas aeruginosa bronchiectasis. Promising
data for both phage candidates is expected to be utilized for planning pivotal Phase 3 clinical trials in 2025.
About MHSRS
The MHSRS is the Department of Defense’s
foremost scientific meeting. It provides a venue for presenting new scientific knowledge resulting from military-unique research and development.
The MHSRS is the premier military or civilian meeting that focuses specifically on the unique medical needs of the warfighter.
The MHSRS provides a collaborative setting for
the exchange of information between military providers with deployment experience, research and academic scientists, international partners,
and industry on research and related health care initiatives falling under the topic areas of Combat Casualty Care, Military Operational
Medicine, Clinical and Rehabilitative Medicine, Information Sciences, Military Infectious Diseases, and Radiation Health Effects.
About Armata Pharmaceuticals, Inc.
Armata is a clinical-stage biotechnology company
focused on the development of pathogen-specific bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat
bacterial infections using its proprietary bacteriophage-based technology. Armata is developing and advancing a broad pipeline of natural
and synthetic phage candidates, including clinical candidates for Pseudomonas aeruginosa, Staphylococcus aureus, and other
pathogens. Armata is committed to advancing phage therapy with drug development expertise that spans bench to clinic including in-house
phage specific cGMP manufacturing.
Forward Looking Statements
This communication contains “forward-looking”
statements as defined by the Private Securities Litigation Reform Act of 1995. These statements relate to future events, results or to
Armata’s future financial performance and involve known and unknown risks, uncertainties and other factors which may cause Armata’s
actual results, performance or events to be materially different from any future results, performance or events expressed or implied by
the forward-looking statements. In some cases, you can identify these statements by terms such as “anticipate,” “believe,”
“could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,”
“predict,” “project,” “should,” “will,” “would” or the negative of those terms,
and similar expressions. These forward-looking statements reflect management’s beliefs and views with respect to future events and
are based on estimates and assumptions as of the date of this communication and are subject to risks and uncertainties including risks
related to Armata’s development of bacteriophage-based therapies; ability to staff and maintain its production facilities under
fully compliant current Good Manufacturing Practices; ability to meet anticipated milestones in the development and testing of the relevant
product; ability to be a leader in the development of phage-based therapeutics; ability to achieve its vision, including improvements
through engineering and success of clinical trials; ability to successfully complete preclinical and clinical development of, and obtain
regulatory approval of its product candidates and commercialize any approved products on its expected timeframes or at all; and Armata’s
estimates regarding anticipated operating losses, capital requirements and needs for additional funds. Additional risks and uncertainties
relating to Armata and its business can be found under the caption “Risk Factors” and elsewhere in Armata’s filings
and reports with the SEC, including in Armata’s Annual Report on Form 10-K, filed with the SEC on March 21, 2024, and
in its subsequent filings with the SEC.
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-2img001.jpg)
Armata expressly disclaims any obligation or undertaking
to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Armata’s
expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.
Media Contacts:
At Armata:
Pierre Kyme
Armata Pharmaceuticals, Inc.
ir@armatapharma.com
310-665-2928 x234
Investor Relations:
Joyce Allaire
LifeSci Advisors, LLC
jallaire@lifesciadvisors.com
212-915-2569
Exhibit 99.3
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img001.jpg)
Corporate Presentation August 26, 2024 NYSE American: ARMP
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img002.jpg)
2 This presentation contains “forward - looking” statements that involve risks, uncertainties and assumptions . If the risks or uncertainties materialize or the assumptions prove incorrect, our results may differ materially from those expressed or implied by such forward - looking statements . All statements other than statements of historical fact could be deemed forward - looking, including, but not limited to : our estimates regarding anticipated operating losses, capital requirements and needs for additional funds ; our ability to raise additional capital when needed and to continue as a going concern ; our ability to manufacture, or otherwise secure the manufacture of, sufficient amounts of our product candidates for our preclinical studies and clinical trials ; our clinical development plans, including planned clinical trials ; our research and development plans, including our clinical development plans ; our ability to select combinations of phages to formulate our product candidates ; our development of bacteriophage - based therapies ; the potential use of bacteriophages to treat bacterial infections ; the potential future of antibiotic resistance ; our ability for bacteriophage therapies to disrupt and destroy biofilms and restore sensitivity to antibiotics ; our planned development strategy, presenting data to regulatory agencies and defining planned clinical studies ; the expected timing of additional clinical trials, including Phase 1 b/Phase 2 or registrational clinical trials ; our ability to manufacture and secure sufficient quantities of our product candidates for clinical trials ; the drug product candidates to be supplied by us for clinical trials ; the potential for bacteriophage technology being uniquely positioned to address the global threat of antibiotic resistance ; the safety and efficacy of our product candidates ; our anticipated regulatory pathways for our product candidates ; the activities to be performed by specific parties in connection with clinical trials ; our ability to successfully complete preclinical and clinical development of, and obtain regulatory approval of our product candidates and commercialize any approved products on our expected timeframes or at all ; our pursuit of additional indications ; the content and timing of submissions to and decisions made by the U . S . Food and Drug Administration (the “FDA”) and other regulatory agencies ; our ability to leverage the experience of our management team and to attract and retain management and keep management and other key personnel ; the capacities and performance of our suppliers, manufacturers, contract research organizations (“CROs”) and other third parties over whom we have limited control ; our ability to staff and maintain our Marina del Rey production facility under fully compliant current Good Manufacturing Practices ; the actions of our competitors and success of competing drugs or other therapies that are or may become available ; our expectations with respect to future growth and investments in our infrastructure, and our ability to effectively manage any such growth ; the size and potential growth of the markets for any of our product candidates, and our ability to capture share in or impact the size of those markets ; the benefits of our product candidates ; potential market growth and market and industry trends ; maintaining collaborations with third parties including our partnership with the Cystic Fibrosis Foundation and the U . S . Department of Defense (the “DoD”) ; potential future collaborations with third parties and the potential markets and market opportunities for product candidates ; our ability to achieve our vision, including improvements through engineering and success of clinical trials ; our ability to meet anticipated milestones for 2024 ; our ability to be a leader in the development of phage - based therapeutics ; the expected use of proceeds from the $ 16 . 3 million DoD grant ; the effects of government regulation and regulatory developments, and our ability and the ability of the third parties with whom we engage to comply with applicable regulatory requirements ; the accuracy of our estimates regarding future expenses, revenues, capital requirements and need for additional financing ; our expectations regarding future planned expenditures ; our ability to achieve and maintain effective internal control over financial reporting in accordance with Section 404 of the Sarbanes - Oxley Act ; our ability to obtain, maintain and successfully enforce adequate patent and other intellectual property protection of any of our products and product candidates ; our ability to protect our intellectual property, including pending and issued patents ; our ability to operate our business without infringing the intellectual property rights of others ; our ability to advance our clinical development programs, which could be impacted by the COVID - 19 pandemic ; the expected impact of the COVID - 19 pandemic on our operations and any statements of assumptions underlying any of the items mentioned ; and statements of belief and any statement of assumptions underlying any of the items mentioned . These statements are based on estimates and information available to us at the time of this presentation and are not guarantees of future performance . Actual results could differ materially from our current expectations as a result of these risks and uncertainties, which include, without limitation, risks related to the ability of our lead clinical candidates, AP - PA 02 and AP - SA 02 (including any modifications thereto) to be more effective than previous candidates ; our ability to enhance AP - PA 02 to treat both CF and NCFB patients ; our ability to develop products as expected ; our expected market opportunity for our products ; our ability to sufficiently fund our operations as expected, including obtaining additional funding as needed, and to refinance, repay or restructure its debt ; and whether Armata will incur unforeseen expenses or liabilities . You should not rely upon forward - looking statements as predictions of future events . Although we believe that the expectations reflected in the forward - looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward - looking statements will be achieved or occur . Moreover, we undertake no obligation to update publicly any forward - looking statements for any reason to conform these statements to actual results or to changes in our expectations except as required by law . We refer you to the documents that we file from time to time with the Securities and Exchange Commission, including our most recently filed Annual Report on Form 10 - K, Quarterly Reports on Form 10 - Q and Current Reports on Form 8 - K . These documents, including the sections therein entitled “Risk Factors,” identify important factors that could cause the actual results to differ materially from those contained in forward - looking statements . In addition, this presentation also contains estimates, projections and other information concerning our industry, our business, and the markets for our product candidates, as well as data regarding market research, estimates and forecasts prepared by our management . Information that is based on estimates, forecasts, projections, market research or similar methodologies is inherently subject to uncertainties and actual events or circumstances may differ materially from events and circumstances reflected in this information . These statements are based upon information available to us as of the date of this presentation, and while we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all potentially available relevant information . Forward Looking Statements
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img003.jpg)
3 Armata Highlights A leading developer of high - purity, pathogen - specific phage therapeutics: • Potential alternative to antibiotics – effective while protecting normal human microbiome • Activity independent of antibiotic resistance, providing critical alternative in setting of increasing MDR worldwide • De - risked modality: worldwide usage (pre - antibiotic era), decades of therapeutic use data ex - US (post - antibiotic era) Two clinical programs ongoing with compelling early data , each approaching major value inflection point: • AP - PA02 : Phase 2 fully enrolled for Pseudomonas aeruginosa in NCFB, readout anticipated in 2H24 • Positive top - line results from Phase 1b/2a trial of inhaled AP - PA02 in patients with cystic fibrosis announced March 2023 • AP - SA02: in Phase 2 for Staphylococcus aureus bacteremia (“diSArm”); readout anticipated in 1H25 Clinical strategy with “parallel pathways” optimizing for both rapid regulatory approval and large commercial opportunity • Commercial models project peak year sales exceeding $2B for AP - PA02 and AP - SA02 across 4 lead indications • Products will benefit from durability and pricing advantages of biologics in U.S. market Agile platform to efficiently develop programs for new or expanded indications Industry leading phage - specific drug manufacturing platform provides competitive advantage and partnerships • In - house cGMP excellence which creates competitive advantage for internal pipeline with optimized purity allowing for higher dose escalation and longer treatments • State of the art fill and finish line with significant proprietary process knowledge • Potential for additional revenue source through large - molecule third party manufacturing contracts Seasoned leadership team brings track record and differentiated relationships with partners • Demonstrated operational excellence and delivery across multiple functional areas • Successful track record in capital raises, M&A, and exits • Deep industry and government relationships have led to non - dilutive financing and potential for future support (e.g., CF Foundation, U.S. Department of Defense) Harnessing significant advantages of phage - based anti - infectives Diversified pipeline allows multiple shots on goal with compelling market opportunities World - class manufacturing facilities and development capabilities Strong leadership team and key partnerships
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img004.jpg)
4 How Phages Kill Bacteria Key Advantages of Phage Therapy Phages Are a Novel Biologic Anti - Infective with Distinct MOA from Antibiotics and Significant Advantages for the Fight Against AMR PHAGE ADVANTAGES Alternative to broad spectrum antibiotics; Solution to address antibiotic - induced microbial resistance • Reduced antibiotic use slows resistance development • Phage activity independent of antibiotic resistance, including MDR infections Agile development approach • Potential for product modifications as clinical isolate landscape evolves, both during development and after launch Parallel clinical development for chronic and/or acute infections • As alternative to, or synergistic to, current antibiotic SOC Safety benefits and historical data • Species - specific, front - line therapy eliminates microbiome disruption that occurs with traditional antibiotics • Decades of published data of therapeutic use in Eastern Europe
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img005.jpg)
5 State of Phage Development and Approval PHAGE ADVANTAGES The phage field has focused on compassionate use cases and individualized medicine. What is urgently needed are definitive pivotal trials that clearly address: • Role of phage therapy as an alternative or augmentation of antibiotics to prevent or delay resistance • Evidence that phage is non - inferior to standard - of - care antibiotics • Demonstrated safety and efficacy complementary to antibiotics Armata has the capabilities and commitment to advancing phage therapy to market and enabling access of this innovative treatment modality to all patients in need globally 5 State of Phage Development and Approval CRITICAL: Prove Phage Therapy Works
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img006.jpg)
6 Clinical Pipeline: Multiple Shots on Goal Phage Evaluation via Multi - Centered Randomized - Controlled Clinical Trials Program Product Discovery Preclinical IND - Cleared Phase 2 Partner Pseudomonas aeruginosa Respiratory Infections AP - PA02 AP - PA03 Staphylococcus aureus AP - SA02 SWARM - P.a. NCT04596319 ; diSArm NCT05184764 ; Tail wind NCT05616221 * Department of Defense (DoD) award received through the Medical Technology Enterprise Consortium (MTEC) and managed by the N ava l Medical Research Command (NMRC) – Naval Advanced Medical Development (NAMD) with funding from the Defense Health Agency and Joint Warfighter Medi cal Research Program. CF: cystic fibrosis; NCFB: non - CF bronchiectasis; PJI: prosthetic joint infection CF NCFB Pneumonia Bacteremia PJI Unpartnered Unpartnered U.S. DoD* Unpartnered DIVERSIFIED PIPELINE
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img007.jpg)
7 Value - Inflection Milestones For Both Programs in Next 12 Months CF: cystic fibrosis; NCFB: non - CF bronchiectasis; SAB: S. aureus bacteremia AP - PA02 CF Ph1b/2a top line data NCFB Ph2 first patient dosed NCFB Ph2 enrollment completion (3Q24) NCFB Ph2 top line data (2H24) AP - SA02 Positions AP - PA02 for Pivotal Study • Chronic, Pseudomonas aeruginosa respiratory infections • Inhaled route of administration Positions AP - SA02 for Pivotal Study • Acute Staphylococcus aureus infections • Intravenous route of administration SAB progression to Ph2a (2H23) SAB Ph2a enrollment completion (2H24) SAB Ph2a topline data (1H25) DIVERSIFIED PIPELINE
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img008.jpg)
8 Pipeline Addresses Significant Unmet Need & Market Opportunity Across Multiple Indications DIVERSIFIED PIPELINE Non-Cystic Fibrosis Bronchiectasis U.S. prevalence (treatable patients)* Key unmet needs for Armata assets Cystic Fibrosis >95,000 >15,000 Total U.S. addressable market size* • Resistance avoidance • Reduce need for suppressive antibiotics • No approved anti - infective standard of care • Reduce need for suppressive antibiotics $2.4B $200M Complicated Bacteremia >50,000 • Persistent high mortality rates • Therapies synergistic with standard of care $700M Prosthetic Joint Infection >27,000 • Penetration to biofilms • Efficacy against resistant organisms $1.2B Chronic treatment Acute treatment PA: Pseudomonas aeruginosa ; SA: Staphylococcus aureus Source: GlobalData * Specific modeling can be discussed under CDA PA PA SA SA
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img009.jpg)
9 Armata has Industry - Leading Capabilities in Developing and Manufacturing Phage Therapeutics From Bench to Clinic Discovery • Phage libraries • Pathogen libraries • Synthetic biologists with phage engineering expertise • Computational biology team Preclinical Development • Well - equipped BSL2 labs • Highly trained microbiologists • Experienced translational biologists • Formulation capabilities PD & Analytical Sciences • Fully equipped for method development • Strong team of biophysical scientists (chemists, structural biologists, etc.) • Internal alignment with manufacturing for efficient method transfer CMC • State - of - the - art cGMP facilities operating multiple clean rooms • In - house Quality Systems Clinical Development • Successful filing of INDs and conduct of FIH studies • Execution of mid - stage studies • Expertise in registrational studies and achieving approval (BLAs and INDs) • Operational expertise inside and outside of the US, support of product launch 01 03 02 04 05 WORLD - CLASS CAPABILITIES
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img010.jpg)
10 Achievements Over the Last 12 Months Demonstrate Operational Excellence Perfected engineered host (removal of toxins and prophages) – well positioned for pivotal trial Optimized fermentation and purification leading to increased yields to support commercialization Optimized excipients for extended shelf life of >18 months at 4 C Control of timelines due to QC assays and manufacturing all in house with trained personnel; 10,000 SF cGMP space including state - of - the - art fill - finish WORLD - CLASS CAPABILITIES Significantly improve clinical trial efficiencies increasing monthly enrollment by 300%; Completed enrollment of Phase 2 NCFB trial High personnel retention at all levels ensuring focus and meeting all timelines from development to trial completion
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img011.jpg)
11 Manufacturing Infrastructure Creates Competitive Advantage and Alternate Revenue Streams State of the art cGMP manufacturing facility • 10,000 square foot purpose - built facility • Essential infrastructure for phage production - Two independent production lines with dedicated upstream and downstream cleanrooms - Ability to manufacture multiple products in parallel - Additional independent Flex Suite with potential to act as a third production line - High - throughput semi - automated aseptic filling line - Versatile configurations for final product form (liquid, powder, vials, syringes) - System turn - around time for different drug product: within 24 hours Scalability provides capacity for contract manufacturing as well as in - house programs • Additional revenue stream from contracting additional space - CMC capabilities and infrastructure adaptable to other advanced biologics - Profitable manufacturing agreement(s) anticipated in 2024/2025 • In - house capabilities derisk late - stage trials and allow for efficient commercial scale production with fewer supply chain disruption threats WORLD - CLASS CAPABILITIES
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img012.jpg)
12 Differentiated Phage Manufacturing Approach Creates Significant Clinical Advantages WORLD - CLASS CAPABILITIES Achieving high purity levels has been a major hurdle for phage drug development • High purity levels creates meaningful clinical differentiators: - Higher dosing - Repetitive IV administration - Wider safety margin Armata’s proprietary processes delivers industry - leading levels of phage purity • End - to - end process, from fermentation to fill and finish, has been optimized to maximize product yield, stability, and purity - Bespoke media formulations - Unique engineered manufacturing hosts - Proprietary excipients to improve product stability • Continuous improvement loop to consistently maximize results and efficiency • Strict dedication to exceeding regulatory requirements
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img013.jpg)
13 Leadership and Board of Directors Diverse Public Company Drug Development Expertise Mina Pastagia, MD CMO Deborah Birx, MD CEO Pierre Kyme, PhD CBO Management Board of Directors Jules Haimovitz Robin Kramer, Chair Todd Peterson, PhD Deborah Birx, MD Odysseas Kostas, MD Joseph Patti, PhD Sarah Schlesinger, MD Peter Hubbard, MBA VP, Operations Suparna Mishra Sarkar, PhD VP, Quality David House SVP, Finance LEADERSHIP AND PARTNERS
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img014.jpg)
14 Strong Relationships with Partners With Demonstrated Interest in Supporting Development of Phage Therapy LEADERSHIP AND PARTNERS Armata Partnerships $5M Therapeutics Development Award • Support Ph1b/2a SWARM - P.a. study • All milestones achieved $3M equity investment (4Q21) $21.6M OTA with DoD through MTEC* • $5.25M received 3Q24 • Funding from DHA and JWMRP • Support Ph1b/2a diSArm study Future Funding Options • Foundation Support: CFF • Government Support: DoD, BARDA, ARPA - H • Strategic long - term equity investment • Pharma partnerships; clinical programs de - risked • Consider additional licensure agreements that attract not - for - profit support & financing Underscores Credibility of Armata’s Clinical Programs * Other Transaction Award (OTA) from U.S. Department of Defense (DoD) received through the Medical Technology Enterprise Consortium (MTEC) and managed by the Naval Medical Research Command (NMRC) – Naval Advanced Medical Development (NAMD) with funding from the Defense Health Agency (DHA) and Joint Warfighter Medical Research Program ( JWMRP). BARDA: Biomedical Advanced Research and Development Authority; ARPA - H: Advanced Research Projects Agency for Health
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img015.jpg)
Cystic Fibrosis Non - CF Bronchiectasis Pseudomonas aeruginosa Program (AP - PA02)
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img016.jpg)
16 Ph1b/2a SWARM - P.a. Study With Inhaled AP - PA02: Completed 1Q23 Outpatient Study in CF Adults with Chronic Pulmonary Pseudomonas aeruginosa Infections Study Objectives Key Inclusion Criteria Study Design (25 US sites) ≥10⁴ CFU of Pa per gram of induced sputum at Screening Pa isolates sensitive to AP - PA02, based on Screening sputum morphotypes For SAD: FEV1 ≥ 60% of predicted normal For MAD: FEV1 ≥ 40% of predicted normal Stable lung function: FEV1 at the Baseline Visit has not decreased by more than 5% compared to the FEV1 at Screening
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img017.jpg)
17 Learnings for SWARM - P.a. Ph1b/2a CF Study AP - PA02 Well - Tolerated with Consistent Exposures by Dose Learnings Safety and Tolerability for up to 10 days bid dosing • No dose - limiting toxicity • No AEs >Grade 1 attributed to study drug: Grade 1 AEs appear to be intermittent with quick recovery Distribution and Clearance • Very low to undetectable systemic exposure after inhalation; no phage detected in urine • Initial assessment of clearance supports q12H dosing Pharmacodynamics (Target Engagement) • Single dose insufficient for CFU reduction • CFU reduction in highest - dosed subjects with higher trough levels (sustained exposure) • Trough level and schedule are key NCFB Phase 2 Tail wind study evaluates optimized dose and schedule
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img018.jpg)
18 NCFB Phase 2 Tail wind Study Design Evaluate AP - PA02 as Monotherapy and in Combination with Inhaled Antibiotics • AP - PA02 nebulized q12h x 10 days • Subject dosing at home • Started with highest dose from CF study (increased dose 2X after lead in) • Evaluate optimized AP - PA02 exposures in correlation with bacterial load reduction and durability Cohort A Cohort B NCFB + confirmed chronic PA infection (Not on chronic inhaled abx) NCFB + confirmed chronic PA infection (On chronic inhaled abx) AP - PA02 bid x 10 days Placebo bid x 10 days AP - PA02 bid x 10 days + SOC inhaled Abx x 28 days SOC Inhaled Abx x 28 days Study Day Study Drug Administration 1 10
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img019.jpg)
19 NCFB Phase 2 Tail wind Study: Fully Enrolled Top - Line Data Expected 2H2024 Enrollment Summary • Accelerated enrollment since 3Q23 • 48 subjects dosed (100%) • 23 sites activated Preliminary Insights into Inhaled AP - PA02* • Multiple - dose administration well tolerated; no significant safety signals • AP - PA02 treated subjects demonstrate a decline in Pseudomonas CFU that persists after treatment has completed • Potential for phage monotherapy as an alternative to rather than in addition to inhaled antibiotics Met Target of Enrollment Completion Mid - 2024 * Preliminary findings are subject to change pending complete data that will be presented in the future
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img020.jpg)
20 Ph3 NCFB Study Design Considerations Evaluation of AP - PA02 Monotherapy as First Approved NCFB Therapeutic Study Objectives / Endpoints Effect of inhaled AP - PA02 monotherapy, administered BID x 48 weeks ** compared to placebo in NCFB chronically infected with P. aeruginosa : • Frequency of pulmonary exacerbations: Reduction by ~30 % • Respiratory function • QoL, respiratory symptoms • Bacterial load reduction ** dosing might be continuous vs. on/off schedule, pending trial data.
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img021.jpg)
Complicated Bacteremia Prosthetic Joint Infection Staphylococcus aureus Program (AP - SA02)
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img022.jpg)
22 Bacteremia Phase 1b/2a “diSArm” Study Enrolling Ph1b (Dose - finding) Enrolls Uncomplicated + Complicated SAB; Ph2a Enrolls Complicated Only Study Endpoints • Phase 1b: Safety and tolerability of multiple intravenous (IV) doses of AP - SA02 • Phase 2a: Clinical Improvement or Response at Day 12, Clinical Improvement or Response at 7 days after completion of antibiotic therapy, Clinical Improvement or Response at End of Study Study Conduct • Phase 1b (n=8; 3:1) • IV dosing every 6 hours for 5 days + Antibiotics • Dose increased from MAD Cohort 1 to MAD Cohort 2 • Phase 2a (n=42; 2:1) • IV dosing every 6 hours for 5 days + Antibiotics • Dose increased further
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img023.jpg)
23 Bacteremia diSArm Phase 1b/2a: Study Status & Enrollment Completion of Enrollment on Track for End - 2024 Enrollment Summary 40 Total Subjects Dosed (80% of study enrolled) • Ph1b, 8 subjects • Ph2a, 32 subjects • Accelerated enrollment since Aug 2023 • Well - tolerated to date – q6 hour infusion for 5 days • Dose escalating towards 5E11 PFU / 24 h • Projected enrollment completion Dec 2024 Site Selection Target = 28 (US & AUS Sites) US • 22 sites activated, open for screening/enrollment • 1 site in study start - up AUS • 5 sites activated, open for screening/enrollment Target Enrollment Completion: End - 2024 Enrollment Projection
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img024.jpg)
24 Early Evidence of AP - SA02 Amplification With Active S. aureus Bacteremia* Early Ph2 PK Data Suggests AP - SA02 is Active and Warrants Further Investigation in a Ph3 Trial • Retention of AP - SA02 phage activity from blood samples collected post dosing • The fact that we can find phage means this subgroup of patients (~50%) may have persistent S. aureus in vivo • The phages are able to find, penetrate, and replicate, subsequently killing the persistent S. aureus despite 48 hours of antibiotics * Preliminary findings are subject to change pending complete data that will be presented in the future
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img025.jpg)
25 Ph3 SAB Study Design Considerations Non - Inferiority Antibiotic Sparing/Reducing Study for Uncomplicated and Complicated SAB Study Objectives/Endpoints • Primary Objective − Demonstrate non - inferiority of AP - SA02 to antibiotics in uncomplicated SAB − Demonstrate non - inferiority of 2 wks of AP - SA02 plus 2 - 3 wks of antibiotics to 4 - 6 wks of antibiotics in complicated SAB • Primary Endpoint: Overall success in mITT population • Patient alive at end of study • No new metastatic foci or complications • Resolution or improvement of clinical signs/symptoms • Two negative blood cultures for S. aureus
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img026.jpg)
Corporate Summary
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img027.jpg)
27 Funding and Capitalization Cash Position • $26.4 million unrestricted cash and cash equivalents at end 2Q24* Financing History • Q1 2020: $25M private placement of common stock and warrants with Innoviva, Inc. • Q1 2021: $20M private placement of common stock and warrants with Innoviva Strategic Opportunities LLC (a subsidiary of Innov iva Inc.) • Q3 2021: $7M private placement of common stock with two investors – Cystic Fibrosis Foundation ($3M) and Innoviva Strategic Opportunities LLC ($4M) • Q1 2022: $45M private placement of common stock and warrants with Innoviva Strategic Opportunities • January 2023: $30M secured convertible credit and security agreement with Innoviva Strategic Opportunities − Mandatory conversion into Armata common stock upon completion of a qualified equity financing − Maturity date: extended to January 10, 2025 • July 2023: $25M secured credit agreement with Innoviva Strategic Opportunities – Maturity date: January 10, 2025 – Collateralized by all assets of Armata and its subsidiaries • March 2024: $35M secured credit agreement with Innoviva Strategic Opportunities – Maturity date: June 4, 2025 – Collateralized by all assets of Armata and its subsidiaries Capitalization • 36.2 million common shares outstanding at end 2Q24* *Preliminary and unaudited and subject to change
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img028.jpg)
28 Strong Global IP Position Through Pending and Issued Patents 14 Patent Families, Long - Life Patents, Patents Granted in all Major Jurisdictions Expiration dates through 2045 with additional competitive moat due to manufacturing complexity and extensive proprietary process development knowledge Jurisdiction Issued Pending U.S. 14 12 R.O.W. 78 60 Armata’s patents and applications cover: • Therapeutic phage cocktails ( Staphylococcus and Pseudomonas ) and uses thereof • Synthetic phage and methods of manufacture thereof • Beneficial effects of phage treatment • Phage combinations • Genetic sequence variations • Sequential use of phages in combination with antibiotics • Methods to reduce antibiotic resistance • Methods to treat bacterial biofilms • Methods to design therapeutic combination panels of phage • Disinfection methods using phages • Phage mutants having increased bacterial host spectra • Treatment and prevention of bacteria - associated cancers • Phages with quorum sensing - quenching activity
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img029.jpg)
29 Grateful to the patients, the research team and site investigators that make this work possible, and to our funders We are privileged to work across the United States and Australia in nearly 75 sites for the three Phase 2 trials We are effective due to top - notch employees that work at Armata everyday to ensure optimized engineered host/phage combinations to reliably produce highly purified phages at high titers meeting quality testing requirements and demonstrating biologic relevance We are grateful to the patient volunteers that understand the need for carefully controlled clinical trials to demonstrate the potential of new investigational drugs
![](https://www.sec.gov/Archives/edgar/data/921114/000110465924092626/tm2422583d1_ex99-3img030.jpg)
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Armata Pharmaceuticals (AMEX:ARMP)
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Armata Pharmaceuticals (AMEX:ARMP)
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From Aug 2023 to Aug 2024