SCHEDULE 10                                  
                                                                               
                   NOTIFICATION OF MAJOR INTERESTS IN SHARES                   

1. Name of company

Acambis plc                                                                    

2. Name of shareholder having a major interest

FMR Corp. (and its direct and indirect subsidiaries incorporating Fidelity     
Management Trust Company (FMTC)), Fidelity International Limited (FIL) (and its
direct and indirect subsidiaries incorporating Fidelity Investment Services    
Limited (FISL)) and Mr Edward C Johnson 3d                                     

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

As above                                                                       

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

State Street Nominees Ltd. 8,000 shares*                                       
                                                                               
Brown Brothers Harriman 6,000 shares*                                          
                                                                               
State Street Bank & Trust 4,300 shares*                                        
                                                                               
Chase Manhattan Bank London 2,845,508 shares**                                 
                                                                               
JP Morgan 21,500 shares                                                        
                                                                               
HSBC 696,305 shares                                                            
                                                                               
Bank of New York London 42,300 shares                                          
                                                                               
Chase Manhattan Bank London 173,268 shares                                     
                                                                               
Chase Nominees Ltd 132,150 shares                                              
                                                                               
Bankers Trust 39,520 shares                                                    
                                                                               
Citibank 110,590 shares                                                        
                                                                               
* For this holding, FMTC acts as the management company                        
                                                                               
** For this holding, FISL acts as the management company                       
                                                                               
For all the other holdings listed, FIL acts as the management company.         

5. Number of shares / amount of stock acquired

N/a                                                                            

6. Percentage of issued class

N/a                                                                            

7. Number of shares / amount of stock disposed

971,905                                                                        

8. Percentage of issued class

0.93%                                                                          

9. Class of security

Ordinary shares of 10p each                                                    

10. Date of transaction

N/a                                                                            

11. Date company informed

18 September 2003                                                              

12. Total holding following this notification

4,079,441 ordinary shares                                                      

13. Total percentage holding of issued class following this notification

3.89%                                                                          

14. Any additional information

N/a                                                                            

15. Name of contact and telephone number for queries

Elizabeth Brown, Company Secretary                                             
                                                                               
+44 (0) 1223 275 300                                                           

16. Name and signature of authorised company official responsible for making
this notification

Elizabeth Brown                                                                

Date of notification

19 September 2003                                                              

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END