RespireRx Pharmaceuticals Inc (CE) (RSPI) News

Sorry for the last link , here it is but it is the same they put out back in Jan 16 2024 nothing new was added . Have a great weekend everyone GLTA
https://www.primarymarkets.com/wp-content/uploads/2024/01/Resolution-RX-new-slide-deck-16-January-2024-NEW-FINAL-FINAL.pdf

wow, that would be a dream come true!!! to a big pharma, that is chump change lol

I know, and I’m not worried. I’m green still as my average is on trips, hopefully we all get rewarded b4 this year ends .

"www.meixatech.com/cv.pdf"
Impressive. Congrats for all you've accomplished.
Did you take any legal action against Martinez? You refer to his email as libelous but isn't it a private communication?

Well got a reply send me questions and I will include back to them , keep in mind that they can't detail insider info please

Paul Franklin

From:
pf@primarymarkets.com
To:
xxxx


Thu, Sep 19 at 11:19 PM

Hi xxxx



I’m speaking with the company (Jeff Margolis and Arnold Lippa) on Tuesday next week so I can have some of your questions answered for you.



Attached is ResolutionRX’s investor presentation from the beginning of this year. I’ll be receiving the updates next week so I’ll pass these on.



As mentioned in the previous correspondence, we’re happy to make an introuction with the company’s management once we’ve recevied the company’s current updates.



Best Regards,

Paul
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I have sent off for the presentation pkg , we will see what it has in it

At current 983M O/S roughly 2.54/share

Yeah that ain’t happening but it ain’t hard do the math. We are at 983m o/s times it by any share price and u got ur market cap

What would a 2.5 billion dollar market cap look like in price/share?

Probably easier on the old brain to just go back to popcorn and pompoms...

Have a good weekend.

It appears so.

Yes a science driven team, however they are a publicly traded company and should have or had business end people associated to match the progress on the science end. Having sustained awareness and value only opens up the doors to opportunities in my mind. Hopefully a plan is in place to change that imbalance.

Actually, it doesn't surprise me. As a scientist (www.meixatech.com/cv.pdf) my focus has always been on science. Money, although important (according to my wife) has never been a priority for me. The RSPI principals up to recently have totally focused on the science (and licensing). Using graduate students (= science slaves) for the research is quite cost-effective. I believe their business model has been to share molecules, but for all groups to agree to adhere to a licensing. Thus, RSP.I has created, a strong science foundation, the value of which could be in the multibillions (IMO)

Thats why I say 2025 is going to be a big year.

Imagine the Phase 2 SCI trial be very successful. How much does that compound alone be worth alongside the entirety of the ampakine platform that may yield benefits for ADHD and other orpan indications.

On top of that there is likely a phase 1 trial with grant money to occur that has implications for both epilpesy and pain indications both of which are massive markets in need and high profile.

Postulating a 2.5 Billion market valuation seems so far fetched....
Of course, a puny 1.1 million market valuation is also far fetched....

I think this gap will be bridged significantly in the coming months and subsequent year.

One of the curiosities I have with the NIH Tier 3 preclincals is does this translate to epilepsy models or is there a different organization that conducts those.

Reason I ask is much of the past work with KRM-ll-81 showed significant promise for epilepsy which needs improved care badly. However, the intent of the NIH preclinicals revolved around pain and mitigating the opioid crisis. Would the tier 3 preclinicals possibly cover both medical indications?

What I am really wondering is the new consultant firm being hired for the gabakine program would they be seeking grant support for BOTH a phase 1 pain trial and a phase 1 epilespy trial congruently?? Or could another interested party be looking at this compound for a specific indication?

Yes it boggles one mind all the publications and preclinical and clinical efforts/success and yet none of this is coalesced into a nice website for potential investors and collaborators to review. It is hard to understand the claims that being on the OTC and blah blah make it difficult to raise funds and have liquidity when communication, awareness and presentation of the company is lacking.

bigtalan: I am now, more than ever, thinking your estimate of RSPI's pipeline value of 2.5 B USD is quite possible..

Folks, There is still a lot more to the GABAkines platform!!! A PhD thesis abstract, which oddly will not be published until 2026. Yes, GL-II-73 appears to be licensed to RSPI. RSPI appears to "own" most of these GABA molecules.

DESIGN AND SYNTHESIS OF ACHIRAL AND CHIRAL GABA RECEPTOR SUBTYPE SELECTIVE LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AS WELL AS EPILEPSY AND ASTHMA
PRITHU MONDAL, University of Wisconsin-Milwaukee
Abstract
DESIGN AND SYNTHESIS OF ACHIRAL AND CHIRAL GABA RECEPTOR SUBTYPE SELECTIVE LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AS WELL AS EPILEPSY by Prithu Mondal The University of Wisconsin-Milwaukee, 2024 Under the Supervision of Professor James M. Cook Gamma-aminobutyric acid type A receptors (GABAAR) are pentameric ligand-gated chloride ion channels located in the membranes, which respond to gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter within the central nervous system (CNS). Benzodiazepines (BZDs) bind to the extracellular interface of the a+?2-subunits of GABAAR. The binding of ligands to different subunits of GABAA receptors, particularly at a1-6ß2/3 ?2 ion channels, can influence a broad spectrum of brain functions. The a1-subtype selective ion channels of GABAARs contribute to sedative, ataxic, amnesic, anticonvulsant, and addictive effects, which should generally be avoided, except for the desirable anti-anxiety and anticonvulsant effects, when designing ligands targeting this BZ allosteric modulatory site. GABAARs containing a2/3 subunits have been associated with anxiolytic, anticonvulsant, and antinociceptive activities. At higher doses, muscle relaxation may be mediated by interactions with a3 subtypes. It is well-established that a5-containing GABAARs play roles in cognition, learning, and memory processes. The dysregulation of GABA activity at a5 subtypes on GABAAR is implicated in the pathophysiology of various CNS disorders, including schizophrenia, major depressive disorder (MDD), bipolar disorder, and specific anxiety disorders like OCD. Additionally, a5 subtypes in the lung play a significant role in exploring potential new treatments for asthma. Drawing from the "privileged imidazodiazepine (IMZD) structures" derived from the unified pharmacophore model of Milwaukee, this research endeavors to design, synthesize, and assess the biological activities of over 120 novel chiral GABAAR a2/a3/a5 or a5 subtype-selective imidazodiazepines (IMDZs) related to SH-053-2'F-R-CH3 and its enantiomer iii SH-053-2'F-S-CH3. The objective is to develop new analogs with enhanced metabolic stability while retaining the desired biological properties with minimal or no side effects for the treatment of CNS disorders and asthma. A subset of compounds from the a5 subtype-selective group demonstrates anxiolytic, antidepressant, and pro-cognitive properties, making them promising candidates for treating major depressive disorders. Approximately 30 grams of a lead compound (GL-II-73) and several analogs were synthesized and assessed. The a5-selective chiral lead amide, GL-II-73, exhibits promising results in rodent models for depression treatment. It demonstrates excellent pharmacokinetic characteristics and displays antidepressant and anxiolytic effects in mice without inducing sedation or motor impairment typically associated with benzodiazepine drugs. Furthermore, it shows improved cognitive effects, which are crucial in treating depression or schizophrenia. Recent studies indicate that administering a single dose of GL-II-73 within 30 minutes can reverse stress-induced or age-related working memory deficits in old mice, restoring their performance levels to approximately 80-90%, nearly equivalent to those of young mice. Typically, old or stressed young mice perform at about 50-60%. Moreover, there was a remarkable reversal of brain cell shrinkage (dendrites and spines) in older mice, typically associated with aging, to a level similar to that of young mice. This exciting development occurred after two months of administering GL-II-73 in the drinking water of the older mice. These findings, presented by collaborator Dr. Etienne Sibille in an interview with the BBC, have resulted in three papers and two patents. There is optimism that the CAMH group led by Sibille can advance this project to human trials within two years, as proposed. Ongoing research by multiple groups continues to explore the potential of these key compounds, including their application in other CNS neurodegenerative diseases. Motivated by the results of GL-II-73( 2'F), a similar analogue was synthesized with the new analogue is different by a single atom (2'Cl). PM-II-26 (2 Cl GL-II-73) showed promising data as an antidepressant and a procognitive compound and further test is going on..Approximately 5g grams of this ligand has been synthesized in good yield to support various biological assays by our collaborators. To further test the 2'Cl series more amides and oxadiazoles were made. One of the oxadiazole PM-II-84E showed promising data as a precognitive compound even at slightly higher doses with no sedation and ataxia. This compound is a very good candidate for further testing. To enhance the iv development of new a2/3 subtype selective agents for treating anxiety disorders, neuropathic pain, epilepsy and asthma we implemented an improved large-scale synthetic method for GL-I-54, MP-III-023, PM-II-26 and PM-II-84E. These ligands, known for their anxiolytic, anticonvulsant, and antinociceptive properties, were synthesized under milder conditions with significantly improved yields. Epilepsy stands as one of the most prevalent neurological conditions, contributing significantly to neurological disability. Approximately 1-2% of the population grapples with this disorder, with about 33% enduring refractory epilepsy. While numerous drugs, including widely prescribed benzodiazepines like Valium and Xanax, are available for neurological disorders such as epilepsy and anxiety, they unfortunately lead to tolerance development within approximately three days, rendering them ineffective. Benzodiazepines bind to the a and ? interface of the gamma-aminobutyric acid type A (GABAA) receptor non-selectively, resulting in adverse effects, including tolerance, addiction, sedation, ataxia, somnolence, and confusion. For the first time, agents like HZ-166 and XHe-II-053, developed in Milwaukee, emerged as a2/a3 receptor subtype-selective ligands with anxiolytic and anticonvulsive activity, devoid of undesired side effects such as sedation and ataxia. However, the ester function in XHe-II-053 and HZ-166 could undergo metabolism into less active corresponding carboxylic acids, resulting in poor exposure, high clearance, and low blood-brain barrier penetration. The replacement of the ester with heterocycles (oxazoles and oxadiazoles) improved metabolic stability and pharmacokinetics, leading to the development of the clinically progressing non-sedating anticonvulsant KRM-II-81. As backup compounds, analogs were designed and synthesized based on the structure of KRM-II-81. Following docking in the human full-length heteromeric a1ß3?2 GABAA receptor subtype CryoEM structure (6HUO), several novel oxazole and oxazoline analogs exhibited potent anticonvulsant activity with enhanced in-vivo and in-vitro stability, free from cytotoxicity, sedation, ataxia, and loss of righting response. Among the many novel KRM-II-81 bioisosteres designed and synthesized, KPP-III-34 (8-bromo substituted imidazodiazepine) demonstrated improved target site (brain) exposure and metabolic stability in plasma and brain, leading to enhanced oral bioavailability ideal for pre-clinical studies. KPP-III-34 exhibited exceptional efficacy in various epilepsy models, including Lamotrigine-resistant seizure models, non-convulsive status epilepticus models, and chronic seizure models, via intraperitoneal (i.p.) or oral v administration in animals (mice or rats). Additionally, KPP-III-34 demonstrated a clean toxicity profile and selectively bound to the rat brain benzodiazepine receptor site without undesired binding to other receptors, according to PDSP (UNC) screens. The facile synthesis of KPP-III-34 was successfully executed on a large scale, requiring no column chromatography or toxic and expensive palladium. KPP-III-34 emerges as a potent and safe backup anticonvulsant agent for the treatment of epilepsy, complementing the clinically progressing KRM-II-81 (ETSP, NINDS). With these improved synthesis methods, we can now supply our collaborators with large quantities of these three a2/3-subtype selective GABAARs PAMs(KRM-II-81,KPP-III-34,DS-II-73 and MP-III-024 efficiently and with high quality. These compounds have demonstrated anxiolytic, anticonvulsant, and antinociceptive effects in numerous animal tests. The availability of gram quantities of these compounds enables further investigation into their ADME toxicity and behavior assays, including those in primates. This facilitates studies in animal models for anxiety, epilepsy, and neuropathic pain, which require substantial amounts of compounds. Additionally, it allows for the execution of long-term safety studies necessary for regulatory approval by the FDA

Just an example of the famous phrase....

"The stock market is a device for transferring money from the impatient to the patient."

While non-investors were exiting their positions leading up to this now EM illiquid market, investors were happily absorbing those same shares. All the due diligence is right out there on this one. In filings, in commentary, etc. Applying a little logic and recognize that the golden goose will eventually lay an egg and patient enough to understand it will lay another and another.... Well you see the point.

Yes 19m at 0019

Just crumbs. Nobody has access to accumulate shares and nobody is giving away shares for peanuts.

Not to say some "experts" wont accumulate shares here and start buying at any prices. Heck I think wasnt there a 25 m bid get filled around .002 right before going EM or something like that?

This company has the goods for a fantastic story. We are just waiting for them to open the curtain.

Arent*

Yeah they letting us break 002 lol

Not good

3,110,000 0.002
10,000 0.0004

Agree. A few crumbs here or there can be the difference between a 200% day and a sliced in half day. Nothing to really glean from trading on the EM.

I do think anticipation will begin to grow as we are approaching Q4 and really with seeking grant funding for KRM-ll-81 as another government funded clinical may surface at any time and the Cx-1739 trial can kick off any time as well I would think among a host of other potential opportunities in the ampakine program.

Considering they cleaned up the language of the preferred shares, I would speculate there might be a funding round in the works. Obviously, they have stated they are seeking funds to rectify the EM status, but clearly also needed to support the platforms into multiple human clinicals. It will be curious if any bigger purse strings take an equity position. I can see RSPI wanting to get through a clinical trial with both the ampakine and gabakine programs before entertaining any big JV/license agreement since a successful trial exponentially increases value of the drug candidate and negotiating power.

The due diligence and early success of the pipeline assets are extremely compelling, we know that. There has been radio silence from the company while we observe progression with publications, opportunity to improve communications and witness time ticking on by closer to "event" timeframes such as the DOD trial and OSA conference, etc. When they begin to tell their story here, it won't be a 1 week wonder stock, this has the making of monster than grows continuously through multiple clinical trials over the next 3-9 months... In my opinion only. Good luck to all.

What’s bid and ask now?

I’m with you DT… it’s a waiting game at this point. Patience is a must… Have a good one brother!

I didn't expect it to hold while on the expert market. Once they file that's when the excitement begins for us who decided to ride this out. In the meantime I do enjoy the green days when we get them just to make the portfolio look better. :)

Maybe you should inquire as to why there has been zero communication related to the OSA program in quite some time. Kinda hard to invest or believe in something when the information flow is stale or non-existant!

At least we know whats coming up next for both the ampakine and gabakine platforms. Although the ResolutionRx website appears much more up to date than the RespireRx website...

Yeah it will be interesting to see how they structure these assets. Could we see either or both the ampakine or gabakine platform spun out into its own entity similar to the OSA platform? Will there be an intermediate route of funding to get them through phase 2 SCI trial and/or a phase 1 trial for KRM-ll-81 where successful trials exponentially increase valuation? One can imagine all types of negotiations ongoing.

I dont really see where the EM/no liquidity and allowing company to be way undervalued helps in this regards and just as important provide any flexibility to acquiring resources and partnerships they need to move through clinical trials..... but maybe they have that all ready to go and we are just waiting for them to unveil all?

I think that more recent 8-k referred to preferred shares only and when those shares can bank a reward on "payment events". I would think this helps opens the door for shorter term capital to enter as that money would want to see funds go towards developing the pipeline. These payment events for prefferred are 15 or 20 million dollars! (depending on class of shares) If/when a payment event occurs of that magnitude this will probably trade at a dime or higher. I think a successful phase 2 for the ampakine program or getting the gabakine grant funding into human clinical phase 1 could easily get stock there. Something we could see early part of 2025 in my opinion.

Lol if u get them phone see about current status

Down 16k today, hopefully one day i wake up a millionaire or a multimillionaire

Down 16k today, hopefully one day o wake up a millionaire or a multimillionaire

Well that was a pretty quick reply from the link I posted yesterday .
Hi XXXX

Hope you are well.

I noticed you recently viewed one of our capital raisings, ResolutionRx, what are your thoughts about the company so far?

Would you be interested in seeing the latest copy of their investor presentation?

As a side note, we are also able to arrange a 1:1 phone / zoom call between you and the management team for ResolutionRx or any of the capital raisings on our Platform to give you an opportunity to conduct further due diligence on the company, their management, and just generally support your research before investing.



If you want to arrange a call with the management team for next week, let me know a time and day that suits you.





Kind Regards,

Andrew Ciantar - Equities Desk Manager

Yes it was , I think a little propping up which I will take in the EM , just waiting for the move to be on whatever market they want to move this into. GLTA

Yeah and that 8-k they dropped earlier this moment basically prohibits them for doing convertibles at this low of sp

A letter to shareholders would be nice all in good time I guess!

For being in EM over 10 weeks there continues to be significant interest and eyes watching this one. The pipeline assets kinda speak for themselves, just looking for some leadership and funding to put it all together and exploit the pent up potential.

Yeah mostly just crumbs floating around. Longs who accumulated and have held as well as any convertibles that didn't bother converting during the DOD news runup is most definitely targeting much higher valuations well into pennyland. Hopefully we are seeing a bit of an appetizer lead into Q4 which is a little over a week away.

Lol it’s Em I ain’t surprised this happened. However I am surprised we had 200-500k buys at 002 range with as long as we been in EM. Literally rare buys across all EM.

That is an incredible encouragement and indication of what could happen here.

See how fast it can go up , it can go that fast too. GLTA

Symbol Last Price $ Change $ Change % Qty # Price Paid $ Day's Gain $ Total Gain $ Total Gain % Value $
RSPI 0.0011 -0.0014 -56.00% 11,640,000 0.00114 -16,296.00 -536.30 -4.02% 12,804.00

Anybody buy or sell this the last couple days. How do you buy or sell with no bid and no offer?

Crack me up, everyone itching to get on board and trade this.

In my mind the BID x ASK might as well be

PEANUTS x NICKEL

.0004 x .0011 now

Can't wait to read the next filing if there ever is one.

Less than 500 bucks worth of shares have changed hands per trading day since entry into the EM. No more than the average Expert Market crap.

Hot stuff, right? You sound excited about it.

Ur must be slow or something no EM trades like this go do some research they crash straight to triple 0’s and stays there. Nice try with ill advised opinions tho

Not your bro. Trading like the typical Expert Market crap.
"No matter the industry or economy condition the market will always comply to product value." And indeed it is.....$.0025.

That will be a nice investment return for you , IMO In a year or two people will look back and see that a .05 Avg was a good starting point. GLTA