By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- Novo Nordisk AS on Monday knocked the air out of Europe's benchmark stock index after a setback in the U.S., while the region's other bourses traded mixed ahead of a meeting of euro-zone finance ministers later in the day.

The Stoxx Europe 600 index lost 0.3% to 286.54, partly erasing a 1.2% gain from Friday.

Asian markets offered little inspiration, as most major markets were closed for holidays.

Shares of Danish drug maker Novo Nordisk (NVO) slumped 12% after the U.S. Food and Drug Administration declined to approve its new-drug applications for insulin Tresiba and a related product, Ryzodeg.

The FDA requested additional cardiovascular trial data, which Novo Nordisk doesn't expect to be able to provide during 2013. .

The setback for Novo Nordisk helped send French rival Sanofi SA (SNY) 4.3% higher, as the two firms have been competing to dominate the lucrative insulin market.

Also on the move in Europe, shares of Dutch food retailer Royal Ahold NV jumped 4.3%. Sweden's Hakon Invest AB said it would buy the 60% of shares it doesn't own in Nordic food retailer ICA for 20 billion Swedish kronor ($3.11 billion) from the Dutch company. Shares of Hakon Invest soared 16% in Stockholm.

The broader moves for the European stock markets followed strong performances on Friday, when bourses rallied after encouraging trade data from China and the U.S.

Monday was light on the data calendar for Europe, with attention falling on the meeting of euro-zone finance ministers, known as the Eurogroup, later in the day in Brussels, where aid package for Cyprus and an evaluation of Greece's progress in its rescue program were likely to top the agenda.

Among country-specific indexes in Europe, the FTSE 100 index rose 0.3% to 6,281.79. Shares of Tesco PLC (TESO) gained 1.2%, after Exane BNP Paribas lifted the supermarkets firm to neutral from underperform.

Germany's DAX 30 index rose 0.2% to 7,669.90, with shares of Commerzbank AG 1.6% higher.

France's CAC 40 index added 0.6% to 3,671.15.

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