Prospectus Filed Pursuant to Rule 424(b)(3) (424b3)

Filed pursuant to Rule 424(b)(3)
File No. 333-227968

EATON VANCE SENIOR INCOME TRUST
Supplement to Prospectus dated October 27, 2020 and Prospectus Supplement dated October 27, 2020

The following replaces any references, contained either in the Prospectus or the Prospectus Supplement, with respect to the Fund’s: (i) last reported sale price; (ii) net asset value (“NAV”) per Common Share; (iii) percentage premium to NAV per Common Share; (iv) number of Common Shares outstanding; and (v) net assets.

On August 16, 2021, the last reported sale price, NAV per Common Share and percentage premium to NAV per Common Share, were $6.94, $6.92 and 0.29%, respectively. As of August 16, 2021, we had 17,536,316 Common Shares outstanding and net assets of approximately $121,375,608.

The following replaces the last sentence in the first paragraph under “Use of Proceeds” in the Prospectus Supplement:

Assuming the sale of all of the Common Shares offered under this Prospectus Supplement and the accompanying Prospectus, at the last reported sale price of $6.94 per share for our Common Shares on the NYSE as of August 16, 2021, we estimate that the net proceeds of this offering will be approximately $12,632,113 after deducting the estimated sales load and the estimated offering expenses payable by the Fund.

August 17, 2021

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