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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K/A
(Amendment No. 1)
CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):
June 5, 2024
SAGIMET BIOSCIENCES INC.
(Exact name of registrant as specified in its
charter)
Delaware |
001-41742 |
20-5991472 |
(State or other jurisdiction
of incorporation) |
(Commission
File Number) |
(I.R.S. Employer
Identification No.) |
Sagimet Biosciences Inc.
155 Bovet Road, Suite 303,
San Mateo, California 94402
(Address of principal executive offices, including
zip code)
(650) 561-8600
(Registrant’s telephone number, including
area code)
Not Applicable
(Former Name or Former Address, if Changed Since
Last Report)
Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
¨ |
Written communications pursuant
to Rule 425 under the Securities Act (17 CFR 230.425) |
¨ |
Soliciting material pursuant
to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
¨ |
Pre-commencement communications
pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
¨ |
Pre-commencement communications
pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act:
Title of each class |
Trade
Symbol(s) |
Name of each exchange on which registered |
Series A Common Stock, $0.0001 par value per share |
SGMT |
The Nasdaq Global Market |
Indicate by check mark whether the registrant is an emerging growth
company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities
Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging
growth company x
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.
Explanatory Note
Sagimet Biosciences Inc. (the “Company”) filed a Current
Report on Form 8-K on June 6, 2024 in connection with a press release announcing the presentation of positive data from
its FASCINATE-2 Phase 2b clinical trial of denifanstat versus placebo in biopsy-confirmed metabolic dysfunction-associated steatohepatitis
(MASH) patients at the European Association for the Study of the Liver (EASL) Congress 2024 (the
“Original 8-K”). This Amendment No. 1 to the Original 8-K is being filed to correct typographical errors in the
press release and file a copy of the revised press release as Exhibit 99.1, and no changes to the other information filed with the
Original Form 8-K have been made.
On June 6, 2024, the Company filed a Current Report on Form 8-K
announcing that the Company issued a press release regarding its presentation of positive data from its FASCINATE-2 Phase 2b clinical
trial of denifanstat versus placebo in biopsy-confirmed metabolic dysfunction-associated steatohepatitis (MASH) patients at the European
Association for the Study of the Liver (EASL) Congress 2024. The press release was revised to correct typographical errors as discussed
in the Explanatory Note and a copy of the revised press release is attached as Exhibit 99.1 to this Current Report on Form 8-K
and is incorporated herein by reference.
Item 9.01 |
Financial Statements and Exhibits. |
(d) Exhibits
SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934,
as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
|
Sagimet Biosciences Inc. |
|
|
|
Date: June 13, 2024 |
By: |
/s/ David Happel |
|
|
David Happel |
|
|
Chief Executive Officer |
Exhibit 99.1
Sagimet Biosciences Presents Data from ITT and
F3 Patient Population in Phase 2b FASCINATE-2 Clinical Trial of Denifanstat at EASL International Liver Congress 2024
Denifanstat achieved statistically significant
results on primary and secondary liver biopsy endpoints in the ITT population, including both histology endpoints recommended in the FDA
draft guidance for accelerated approval in MASH
Denifanstat showed a statistically significant
improvement in liver fibrosis ≥1-stage without worsening of MASH in ITT population, including in patients with baseline stage 3 fibrosis
Statistical significance also shown in improvement
of liver fibrosis ≥2-stage without worsening of MASH in the mITT population, including in patients with stage 3 fibrosis
Tripalmitin, a biomarker
of denifanstat activity, showed an early and sustained reduction in de novo lipogenesis at 4-weeks
Safety in the ITT population showed denifanstat
was generally well tolerated
Management to host live webcast with Principal
Investigator Dr. Rohit Loomba at 9:30 AM PT (12:30 PM ET) on Thursday, June 13, 2023
SAN MATEO, Calif., June 6, 2024
(GLOBE NEWSWIRE) -- Sagimet Biosciences Inc. (Sagimet, Nasdaq: SGMT), a clinical-stage biopharmaceutical company developing novel fatty
acid synthase (FASN) inhibitors designed to target dysfunctional metabolic and fibrotic pathways, presented positive data from its FASCINATE-2
Phase 2b clinical trial of denifanstat versus placebo in biopsy-confirmed metabolic dysfunction-associated steatohepatitis (MASH) patients
at the European Association for the Study of the Liver (EASL) Congress being held in Milan, Italy. Sagimet’s lead drug candidate,
denifanstat, is an oral, once-daily pill and selective FASN inhibitor in development for the treatment of MASH.
“Our presentation of the FASCINATE-2
study data shows the strong impact of denifanstat, a novel therapeutic designed to reduce the three main drivers of MASH - fat accumulation,
inflammation, and fibrosis. The week 52 data on the improvement of fibrosis both by ≥ 1 and ≥ 2 stages, particularly in the F3 patient
population, are very encouraging and differentiate denifanstat,” said Dave Happel, Chief Executive Officer of Sagimet. “Our
focus now shifts to initiating our Phase 3 registrational program for the development of denifanstat in MASH with fibrosis in the second
half of this year.”
Positive top line data was
announced for the FASCINATE-2 Phase 2b study on January 22, 2024 (here). In the EASL presentation, additional 52-week ITT
and F3 subgroup efficacy data included:
| · | The primary endpoint of ≥2-point reduction in NAS (NAFLD Activity Score)
without worsening of fibrosis (16% placebo vs 38% with denifanstat, p=0.0035) or MASH resolution with ≥2-point reduction in NAS resolution
without worsening of fibrosis (11% placebo vs 26% with denifanstat, p=0.0173) in the intention to treat (ITT) population. |
| · | Secondary endpoints of fibrosis improvement by ≥ 1 stage with no worsening
of MASH in the ITT (14% placebo vs 30% with denifanstat, p=0.0199) and F3 (13% placebo vs 49% with denifanstat, p=0.0032) populations,
and fibrosis improvement by ≥ 2 stages with no worsening of MASH in the mITT (2% placebo vs 20% with denifanstat, p=0.0065) and F3
(4% placebo vs 34% with denifanstat, p=0.0050) populations. |
| · | Data on significant increase in beneficial polyunsaturated triglycerides
at the end of 52 week of treatment (-4% placebo vs +42% denifanstat, p<0.001) in the mITT population. |
| · | A biomarker of denifanstat activity (tripalmitin) showed an early and sustained
reduction in de novo lipogenesis at 4-weeks (-0.4ug/mL placebo vs -2.4ug/ml with denifanstat, p=0.001) and 13-weeks (-0.1ug/mL placebo
vs -2.1ug/mL with denifanstat, p=0.005) in the mITT population. |
“Denifanstat is the only FASN
inhibitor currently in clinical development for MASH,” commented Rohit Loomba, M.D., M.H.Sc., Professor of Medicine, Chief, Division
of Gastroenterology and Hepatology, and Director, MASLD Research Center, University of California San Diego, who serves as a scientific
advisor for Sagimet on its ongoing development of denifanstat. “After one year of treatment, denifanstat was significantly better
than placebo for both MASH resolution without worsening of fibrosis as well as 1 stage or greater improvements in fibrosis stage. As an
oral small molecule, denifanstat shows robust improvements in patients with F3 fibrosis which supports its continued development in patients
with moderate to advanced fibrosis due to MASH.”
Endpoints and Improvements From
FASCINATE-2 Reported at EASL 2024
|
|
Patient Population |
|
Denifanstat 50 mg |
|
|
Placebo |
|
|
P-value vs placebo |
|
Primary Endpoints |
|
|
|
|
|
|
|
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≥ 2-point decrease in NAS without worsening of fibrosis |
|
ITT |
|
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38 |
% |
|
|
16 |
% |
|
|
0.0035 |
|
MASH resolution without worsening of fibrosis with ≥2-point reduction in NAS |
|
ITT |
|
|
26 |
% |
|
|
11 |
% |
|
|
0.0173 |
|
Other Endpoints |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Improvement of fibrosis by ≥ 1 stage with no worsening of MASH |
|
ITT |
|
|
30 |
% |
|
|
14 |
% |
|
|
0.0199 |
|
|
|
mITT- F3 |
|
|
49 |
% |
|
|
13 |
% |
|
|
0.0032 |
|
Improvement of fibrosis by ≥ 2 stage with no worsening of MASH |
|
mITT |
|
|
20 |
% |
|
|
2 |
% |
|
|
0.0065 |
|
|
|
mITT- F3 |
|
|
34 |
% |
|
|
4 |
% |
|
|
0.0050 |
|
Polyunsaturated Triglycerides |
|
mITT |
|
|
+42 |
% |
|
|
-4 |
% |
|
|
<0.001 |
|
Tripalmitin* |
|
mITT |
|
|
-2.1ug/mL |
|
|
|
-0.1ug/mL |
|
|
|
0.005 |
|
Modified intent-to-treat
population (mITT) includes all patients with paired biopsies, n=81 denifanstat, n=45 placebo; ITT population: n =112 denifanstat, n=56
placebo.
*13-week timepoint
Safety and Tolerability
As in prior studies, no treatment-related
serious adverse events (SAEs) were observed, and the majority of adverse events (AEs) were mild to moderate in nature (Grades 1 and 2).
There were no Grade ≥3 treatment-related AEs, and no drug-induced liver injury (DILI) signal in the study. The most common treatment-related
AEs by system organ class (observed in ≥5% of patients in the study) were eye disorders (denifanstat 15.2%, placebo 16.1%), gastrointestinal
disorders (denifanstat 11.6%, placebo 8.9%), and skin and subcutaneous tissue disorders (denifanstat 22.3%, placebo 7.1%). The incidence
of treatment emergent adverse events (TEAEs) leading to treatment discontinuation was 19.6% in the denifanstat group compared to 5.4%
in placebo.
Webcast Information
Management will host a live webcast
with Principal Investigator Dr. Rohit Loomba at 9:30 AM PT (12:30 PM ET) on Thursday, June 13, 2024 to discuss the data; participants
will have the opportunity to participate in a chat-based Q&A session. The webcast will be available in the Events & Presentation
section of Sagimet’s website at www.sagimet.com, with an archived replay available for approximately 90 days following the
event. Dr. Loomba’s full curriculum vitae (CV) and disclosure of conflicts of interest (COI) can be found in the EASL presentation
which is available in the Posters & Publications section of Sagimet’s website at www.sagimet.com.
About the Phase 2b FASCINATE-2
Clinical Trial
The Phase 2b FASCINATE-2 clinical
trial was a 52-week randomized, double-blind, placebo-controlled trial that evaluated the safety and histological impact of denifanstat
compared to placebo in 168 biopsy-confirmed MASH patients with moderate-to-severe fibrosis (stage F2 or F3) with NAS ≥4. Patients were
randomized 2:1 to receive 50 mg denifanstat or placebo, taken orally once daily. An end-of-trial biopsy was assessed by a central pathologist
for histological endpoints. Liver biopsies were also analyzed using AI-based digital pathology.
About Sagimet
Biosciences
Sagimet is a clinical-stage biopharmaceutical
company developing novel fatty acid synthase (FASN) inhibitors that are designed to target dysfunctional metabolic pathways in diseases
resulting from the overproduction of the fatty acid, palmitate. Sagimet’s lead drug candidate, denifanstat, is an oral, once-daily
pill and selective FASN inhibitor in development for the treatment of MASH. FASCINATE-2, a Phase 2b clinical trial of denifanstat in
MASH with liver biopsy-based primary endpoints, was successfully completed with positive results. For additional information about Sagimet,
please visit www.sagimet.com.
About MASH
MASH is a progressive and severe liver
disease which is estimated to impact more than 115 million people worldwide, for which there is only one recently approved treatment in
the United States and no currently approved treatments in Europe. In 2023, global liver disease medical societies and patient groups formalized
the decision to rename non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated steatotic liver disease (MASLD) and
nonalcoholic steatohepatitis (NASH) to metabolic dysfunction-associated steatohepatitis (MASH). Additionally, an overarching term, steatotic
liver disease (SLD), was established to capture multiple types of liver diseases associated with fat buildup in the liver. The goal of
the name change was to establish an affirmative, non-stigmatizing name and diagnosis.
Forward-Looking
Statements
This press release contains forward-looking
statements within the meaning of, and made pursuant to the safe harbor provisions of, The Private Securities Litigation Reform Act of
1995. All statements contained in this press release, other than statements of historical facts or statements that relate to present facts
or current conditions, including but not limited to, statements regarding: the expected timing of the presentation of data from ongoing
clinical trials, Sagimet’s clinical development plans and related anticipated development milestones, Sagimet’s cash and financial
resources and expected cash runway. These statements involve known and unknown risks, uncertainties and other important factors that may
cause Sagimet’s actual results, performance or achievements to be materially different from any future results, performance or achievements
expressed or implied by the forward-looking statements. In some cases, these statements can be identified by terms such as “may,”
“might,” “will,” “should,” “expect,” “plan,” “aim,” “seek,”
“anticipate,” “could,” “intend,” “target,” “project,” “contemplate,”
“believe,” “estimate,” “predict,” “forecast,” “potential” or “continue”
or the negative of these terms or other similar expressions.
The forward-looking statements in
this press release are only predictions. Sagimet has based these forward-looking statements largely on its current expectations and projections
about future events and financial trends that Sagimet believes may affect its business, financial condition and results of operations.
These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and
assumptions, some of which cannot be predicted or quantified and some of which are beyond Sagimet’s control, including, among others:
the clinical development and therapeutic potential of denifanstat or any other drug candidates Sagimet may develop; Sagimet’s ability
to advance drug candidates into and successfully complete clinical trials, including its FASCINATE-2 Phase 3 clinical trial; Sagimet’s
relationship with Ascletis, and the success of its development efforts for denifanstat; the accuracy of Sagimet’s estimates regarding
its capital requirements; and Sagimet’s ability to maintain and successfully enforce adequate intellectual property protection.
These and other risks and uncertainties are described more fully in the “Risk Factors” section of Sagimet’s most recent
filings with the Securities and Exchange Commission and available at www.sec.gov. You should not rely on these forward-looking statements
as predictions of future events. The events and circumstances reflected in these forward-looking statements may not be achieved or occur,
and actual results could differ materially from those projected in the forward-looking statements. Moreover, Sagimet operates in a dynamic
industry and economy. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict
all risk factors and uncertainties that Sagimet may face. Except as required by applicable law, Sagimet does not plan to publicly update
or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances
or otherwise.
Contact:
Joyce Allaire
LifeSci Advisors
JAllaire@lifesciadvisors.com
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