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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 10-Q
(Mark One)
☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended June 30, 2024
OR
☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from _________________ to ___________________
Commission File Number: 001-39335
Repare Therapeutics Inc.
(Exact Name of Registrant as Specified in its Charter)
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Québec |
Not applicable |
(State or other jurisdiction of incorporation or organization) |
(I.R.S. Employer Identification No.) |
7171 Frederick-Banting, Building 2, Suite 270 St-Laurent, Québec, Canada |
H4S 1Z9 |
(Address of principal executive offices) |
(Zip Code) |
Registrant’s telephone number, including area code: (857) 412-7018
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class |
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Trading Symbol(s) |
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Name of each exchange on which registered |
Common shares, no par value |
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RPTX |
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The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
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Large accelerated filer |
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☐ |
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Accelerated filer |
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☒ |
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Non-accelerated filer |
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☐ |
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Smaller reporting company |
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☒ |
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Emerging growth company |
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☐ |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
As of August 2, 2024, there were 42,445,533 of the registrant’s common shares, no par value per share, outstanding.
Table of Contents
SPECIAL NOTE REGARDING FORWARD LOOKING STATEMENTS
This Quarterly Report on Form 10-Q contains forward-looking statements about us and our industry that involve substantial risks and uncertainties. All statements other than statements of historical facts contained in this Quarterly Report on Form 10-Q, including statements regarding our strategy, future financial condition, future operations, research and development costs, plans and objectives of management, are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “aim,” “anticipate,” “assume,” “believe,” “contemplate,” “continue,” “could,” “design,” “due,” “estimate,” “expect,” “goal,” “intend,” “may,” “objective,” “plan,” “predict,” “positioned,” “potential,” “seek,” “should,” “target,” “will,” “would” and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. Although we believe that we have a reasonable basis for each forward-looking statement contained in this Quarterly Report on Form 10-Q, we caution you that these statements are based on a combination of facts and factors currently known by us and our expectations of the future, about which we cannot be certain.
The forward-looking statements in this Quarterly Report on Form 10-Q include, among other things, statements about:
•the initiation, timing, progress and results of our current and future preclinical studies and clinical trials and related preparatory work and the period during which the results of the trials will become available, as well as our research and development programs;
•our estimates regarding expenses, future revenue, capital requirements and needs for additional financing;
•our ability to obtain regulatory approval of lunresertib, camonsertib and any of our other current and future product candidates that we develop;
•our ability to identify and develop additional product candidates using our SNIPRx platform;
•business disruptions affecting the initiation, patient enrollment, development and operation of our clinical trials, including a public health emergency or pandemic;
•the evolving impact of macroeconomic events, including health pandemics, changes in inflation, the U.S. Federal Reserve raising interest rates, disruptions in access to bank deposits or lending commitments due to bank failures and the Russia-Ukraine and Middle-East conflicts, on our operations, supply chains, general economic conditions, our ability to raise additional capital, and the continuity of our business, including our preclinical studies and clinical trials;
•our ability to enroll patients in clinical trials, to timely and successfully complete those trials and to receive necessary regulatory approvals;
•the timing of completion of enrollment and availability of data from our current preclinical studies and clinical trials, including ongoing clinical trials of lunresertib, camonsertib and RP-1664;
•the expected timing of filings with regulatory authorities for any product candidates that we develop;
•our expectations regarding the potential market size and the rate and degree of market acceptance for any current or future product candidates that we develop;
•our ability to receive any milestone or royalty payments under our collaboration and license agreements;
•the anticipated impact of the termination of our collaboration with Hoffmann-La Roche Inc. and F. Hoffmann-La Roche Ltd for the development and commercialization of camonsertib, including our expectations regarding the development of camonsertib following the transition of commercial and development rights in camonsertib back to us;
•our ability to realize the benefits of the collaboration compounds retained by us following the termination of our collaboration with F. Hoffmann-La Roche Ltd and Hoffman-La Roche Inc.;
•the effects of competition with respect to lunresertib, camonsertib, or any of our other current or future product candidates, as well as innovations by current and future competitors in our industry;
•our ability to fund our working capital requirements;
•our intellectual property position, including the scope of protection we are able to establish, maintain and enforce for intellectual property rights covering our product candidates;
•our financial performance and our ability to effectively manage our anticipated growth;
•our ability to obtain additional funding for our operations; and
•other risks and uncertainties, including those listed under the section titled “Risk Factors” in this Quarterly Report and elsewhere in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the Securities and Exchange Commission (the “SEC”) on February 28, 2024.
Although we believe that the expectations reflected in these forward-looking statements are reasonable, these statements relate to our strategy, future operations, future financial position, future revenue, projected costs, prospects, plans, objectives of management and expected market growth, and involve known and unknown risks, uncertainties and other factors including, without limitation, risks, uncertainties and assumptions regarding the impact of the macroeconomic events on our business, operations, strategy, goals and anticipated timelines, our ongoing and planned preclinical activities, our ability to initiate, enroll, conduct or complete ongoing and planned clinical trials, our timelines for regulatory submissions and our financial position that may cause our actual results, levels of activity, performance or achievements to be materially different from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. You are urged to carefully review the disclosures we make concerning these risks and other factors that may affect our business and operating results in this Quarterly Report on Form 10-Q. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this document. Except as required by law, we do not intend, and undertake no obligation, to update any forward-looking information to reflect events or circumstances.
PART I—FINANCIAL INFORMATION
Item 1. Financial Statements.
Repare Therapeutics Inc.
Condensed Consolidated Balance Sheets
(Unaudited)
(Amounts in thousands of U.S. dollars, except share data)
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As of June 30, |
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As of December 31, |
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2024 |
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2023 |
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ASSETS |
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CURRENT ASSETS: |
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Cash and cash equivalents |
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$ |
79,820 |
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$ |
111,268 |
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Marketable securities |
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128,303 |
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112,359 |
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Income tax receivable |
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11,072 |
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10,813 |
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Other current receivables |
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3,571 |
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4,499 |
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Prepaid expenses |
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5,773 |
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4,749 |
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Total current assets |
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228,539 |
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243,688 |
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Property and equipment, net |
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3,226 |
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4,215 |
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Operating lease right-of-use assets |
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2,195 |
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3,326 |
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Income tax receivable |
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1,077 |
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2,276 |
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Other assets |
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307 |
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396 |
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TOTAL ASSETS |
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$ |
235,344 |
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$ |
253,901 |
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LIABILITIES AND SHAREHOLDERS’ EQUITY |
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CURRENT LIABILITIES: |
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Accounts payable |
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$ |
7,182 |
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$ |
2,400 |
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Accrued expenses and other current liabilities |
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22,310 |
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24,057 |
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Operating lease liability, current portion |
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1,957 |
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2,400 |
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Deferred revenue, current portion |
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— |
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10,222 |
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Total current liabilities |
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31,449 |
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39,079 |
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Operating lease liability, net of current portion |
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218 |
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1,010 |
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Deferred revenue, net of current portion |
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— |
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1,730 |
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TOTAL LIABILITIES |
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31,667 |
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41,819 |
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SHAREHOLDERS’ EQUITY |
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Preferred shares, no par value per share; unlimited shares authorized as of June 30, 2024 and December 31, 2023, respectively; 0 shares issued and outstanding as of June 30, 2024, and December 31, 2023, respectively |
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— |
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— |
|
Common shares, no par value per share; unlimited shares authorized as of June 30, 2024 and December 31, 2023; 42,445,533 and 42,176,041 shares issued and outstanding as of June 30, 2024 and December 31, 2023, respectively |
|
|
486,375 |
|
|
|
483,350 |
|
Additional paid-in capital |
|
|
72,157 |
|
|
|
61,813 |
|
Accumulated other comprehensive (loss) income |
|
|
(134 |
) |
|
|
28 |
|
Accumulated deficit |
|
|
(354,721 |
) |
|
|
(333,109 |
) |
Total shareholders’ equity |
|
|
203,677 |
|
|
|
212,082 |
|
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY |
|
$ |
235,344 |
|
|
$ |
253,901 |
|
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements
Repare Therapeutics Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(Unaudited)
(Amounts in thousands of U.S. dollars, except share and per share data)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Revenue: |
|
|
|
|
|
|
|
|
|
|
|
|
Collaboration agreements |
|
$ |
1,073 |
|
|
$ |
30,249 |
|
|
$ |
53,477 |
|
|
$ |
35,927 |
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
|
|
|
Research and development, net of tax credits |
|
|
30,075 |
|
|
|
33,788 |
|
|
|
63,045 |
|
|
|
65,618 |
|
General and administrative |
|
|
8,317 |
|
|
|
8,719 |
|
|
|
16,935 |
|
|
|
17,248 |
|
Total operating expenses |
|
|
38,392 |
|
|
|
42,507 |
|
|
|
79,980 |
|
|
|
82,866 |
|
Loss from operations |
|
|
(37,319 |
) |
|
|
(12,258 |
) |
|
|
(26,503 |
) |
|
|
(46,939 |
) |
Other income (expense), net |
|
|
|
|
|
|
|
|
|
|
|
|
Realized and unrealized gain (loss) on foreign exchange |
|
|
6 |
|
|
|
(41 |
) |
|
|
37 |
|
|
|
(97 |
) |
Interest income |
|
|
2,894 |
|
|
|
3,489 |
|
|
|
5,862 |
|
|
|
6,916 |
|
Other expense |
|
|
(29 |
) |
|
|
(26 |
) |
|
|
(53 |
) |
|
|
(41 |
) |
Total other income, net |
|
|
2,871 |
|
|
|
3,422 |
|
|
|
5,846 |
|
|
|
6,778 |
|
Loss before income taxes |
|
|
(34,448 |
) |
|
|
(8,836 |
) |
|
|
(20,657 |
) |
|
|
(40,161 |
) |
Income tax expense |
|
|
(326 |
) |
|
|
(3,110 |
) |
|
|
(955 |
) |
|
|
(6,726 |
) |
Net loss |
|
$ |
(34,774 |
) |
|
$ |
(11,946 |
) |
|
$ |
(21,612 |
) |
|
$ |
(46,887 |
) |
Other comprehensive (loss) income: |
|
|
|
|
|
|
|
|
|
|
|
|
Unrealized (loss) gain on available-for-sale marketable securities |
|
$ |
(21 |
) |
|
$ |
(189 |
) |
|
$ |
(162 |
) |
|
$ |
4 |
|
Total other comprehensive (loss) income |
|
|
(21 |
) |
|
|
(189 |
) |
|
|
(162 |
) |
|
|
4 |
|
Comprehensive loss |
|
$ |
(34,795 |
) |
|
$ |
(12,135 |
) |
|
$ |
(21,774 |
) |
|
$ |
(46,883 |
) |
Net loss per share attributable to common shareholders - basic and diluted |
|
$ |
(0.82 |
) |
|
$ |
(0.28 |
) |
|
$ |
(0.51 |
) |
|
$ |
(1.11 |
) |
Weighted-average common shares outstanding - basic and diluted |
|
|
42,445,462 |
|
|
|
42,089,530 |
|
|
|
42,339,732 |
|
|
|
42,065,237 |
|
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements
Repare Therapeutics Inc.
Condensed Consolidated Statements of Shareholders’ Equity
(Unaudited)
(Amounts in thousands of U.S. dollars, except share data)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common Shares |
|
|
Additional Paid-in |
|
|
Accumulated Other Comprehensive |
|
|
Accumulated |
|
|
Total Shareholders’ |
|
|
|
Shares |
|
|
Amount |
|
|
Capital |
|
|
Income (Loss) |
|
|
Deficit |
|
|
Equity |
|
Balance, December 31, 2022 |
|
|
42,036,193 |
|
|
$ |
482,032 |
|
|
$ |
37,226 |
|
|
$ |
(428 |
) |
|
$ |
(239,313 |
) |
|
$ |
279,517 |
|
Share-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
6,062 |
|
|
|
— |
|
|
|
— |
|
|
|
6,062 |
|
Exercise of stock options |
|
|
2,000 |
|
|
|
7 |
|
|
|
(3 |
) |
|
|
— |
|
|
|
— |
|
|
|
4 |
|
Issuance of common shares under the 2020 Employee Share Purchase Plan |
|
|
41,703 |
|
|
|
638 |
|
|
|
(229 |
) |
|
|
— |
|
|
|
— |
|
|
|
409 |
|
Other comprehensive income |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
193 |
|
|
|
— |
|
|
|
193 |
|
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(34,941 |
) |
|
|
(34,941 |
) |
Balance, March 31, 2023 |
|
|
42,079,896 |
|
|
$ |
482,677 |
|
|
$ |
43,056 |
|
|
$ |
(235 |
) |
|
$ |
(274,254 |
) |
|
$ |
251,244 |
|
Share-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
6,265 |
|
|
|
— |
|
|
|
— |
|
|
|
6,265 |
|
Exercise of stock options |
|
|
14,050 |
|
|
|
62 |
|
|
|
(22 |
) |
|
|
— |
|
|
|
— |
|
|
|
40 |
|
Other comprehensive loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(189 |
) |
|
|
— |
|
|
|
(189 |
) |
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(11,946 |
) |
|
|
(11,946 |
) |
Balance, June 30, 2023 |
|
|
42,093,946 |
|
|
$ |
482,739 |
|
|
$ |
49,299 |
|
|
$ |
(424 |
) |
|
$ |
(286,200 |
) |
|
$ |
245,414 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Balance, December 31, 2023 |
|
|
42,176,041 |
|
|
$ |
483,350 |
|
|
$ |
61,813 |
|
|
$ |
28 |
|
|
$ |
(333,109 |
) |
|
$ |
212,082 |
|
Share-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
6,475 |
|
|
|
— |
|
|
|
— |
|
|
|
6,475 |
|
Exercise of stock options |
|
|
8,485 |
|
|
|
27 |
|
|
|
(10 |
) |
|
|
— |
|
|
|
— |
|
|
|
17 |
|
Issuance of common shares on vesting of restricted share units |
|
|
200,262 |
|
|
|
2,488 |
|
|
|
(2,488 |
) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
Issuance of common shares under the 2020 Employee Share Purchase Plan |
|
|
60,618 |
|
|
|
510 |
|
|
|
(152 |
) |
|
|
— |
|
|
|
— |
|
|
|
358 |
|
Other comprehensive loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(141 |
) |
|
|
— |
|
|
|
(141 |
) |
Net income |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
13,162 |
|
|
|
13,162 |
|
Balance, March 31, 2024 |
|
|
42,445,406 |
|
|
$ |
486,375 |
|
|
$ |
65,638 |
|
|
$ |
(113 |
) |
|
$ |
(319,947 |
) |
|
$ |
231,953 |
|
Share-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
6,519 |
|
|
|
— |
|
|
|
— |
|
|
|
6,519 |
|
Exercise of stock options |
|
|
127 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
Other comprehensive loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(21 |
) |
|
|
— |
|
|
|
(21 |
) |
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(34,774 |
) |
|
|
(34,774 |
) |
Balance, June 30, 2024 |
|
|
42,445,533 |
|
|
$ |
486,375 |
|
|
$ |
72,157 |
|
|
$ |
(134 |
) |
|
$ |
(354,721 |
) |
|
$ |
203,677 |
|
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements
Repare Therapeutics Inc.
Condensed Consolidated Statements of Cash Flows
(Unaudited)
(Amounts in thousands of U.S. dollars)
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
Cash Flows From Operating Activities: |
|
|
|
|
|
|
Net loss for the period |
|
$ |
(21,612 |
) |
|
$ |
(46,887 |
) |
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
|
|
Share-based compensation expense |
|
|
12,994 |
|
|
|
12,327 |
|
Depreciation expense |
|
|
989 |
|
|
|
947 |
|
Non-cash lease expense |
|
|
1,131 |
|
|
|
1,086 |
|
Foreign exchange (gain) loss |
|
|
(27 |
) |
|
|
60 |
|
Net accretion of marketable securities |
|
|
(2,908 |
) |
|
|
(3,928 |
) |
Changes in operating assets and liabilities: |
|
|
|
|
|
|
Prepaid expenses |
|
|
(1,024 |
) |
|
|
1,518 |
|
Other current receivables |
|
|
910 |
|
|
|
(988 |
) |
Other non-current assets |
|
|
89 |
|
|
|
89 |
|
Accounts payable |
|
|
4,785 |
|
|
|
4,429 |
|
Accrued expenses and other current liabilities |
|
|
(1,731 |
) |
|
|
(17 |
) |
Operating lease liability, current portion |
|
|
(401 |
) |
|
|
72 |
|
Income taxes |
|
|
940 |
|
|
|
(2,991 |
) |
Operating lease liability, net of current portion |
|
|
(765 |
) |
|
|
(1,172 |
) |
Deferred revenue |
|
|
(11,952 |
) |
|
|
(30,677 |
) |
Net cash used in operating activities |
|
|
(18,582 |
) |
|
|
(66,132 |
) |
Cash Flows From Investing Activities: |
|
|
|
|
|
|
Purchases of property and equipment |
|
|
— |
|
|
|
(1,540 |
) |
Proceeds from maturities of marketable securities |
|
|
89,015 |
|
|
|
169,000 |
|
Purchase of marketable securities |
|
|
(102,213 |
) |
|
|
(145,796 |
) |
Net cash (used in) provided by investing activities |
|
|
(13,198 |
) |
|
|
21,664 |
|
Cash Flows From Financing Activities: |
|
|
|
|
|
|
Proceeds from exercise of stock options |
|
|
17 |
|
|
|
44 |
|
Proceeds from issuance of common stock under the 2020 Employee Share Purchase Plan |
|
|
358 |
|
|
|
409 |
|
Net cash provided by financing activities |
|
|
375 |
|
|
|
453 |
|
Effect of exchange rate fluctuations on cash held |
|
|
(43 |
) |
|
|
38 |
|
Net Decrease In Cash And Cash Equivalents |
|
|
(31,448 |
) |
|
|
(43,977 |
) |
Cash and cash equivalents at beginning of period |
|
|
111,268 |
|
|
|
159,521 |
|
Cash and cash equivalents at end of period |
|
$ |
79,820 |
|
|
$ |
115,544 |
|
|
|
|
|
|
|
|
Supplemental Disclosure Of Cash Flow Information: |
|
|
|
|
|
|
Right-of-use asset obtained in exchange for new operating lease liability |
|
$ |
— |
|
|
$ |
149 |
|
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements
REPARE THERAPEUTICS INC.
NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(Amounts in U.S. dollars, unless otherwise specified)
1. Organization and Nature of Business
Repare Therapeutics Inc. (“Repare” or the “Company”) is a precision medicine oncology company focused on the development of synthetic lethality-based therapies for patients with cancer. The Company is governed by the Business Corporations Act (Québec). The Company’s common shares are listed on the Nasdaq Global Select Market under the ticker symbol “RPTX”.
2. Summary of Significant Accounting Policies
Basis of Presentation
The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America (“U.S. GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and as amended by Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”).
The unaudited condensed consolidated financial statements have been prepared on the same basis as the audited annual consolidated financial statements as of and for the year ended December 31, 2023, and, in the opinion of management, reflect all adjustments, consisting of normal recurring adjustments, necessary for the fair presentation of the Company’s consolidated financial position as of June 30, 2024, the consolidated results of its operations for the three and six months ended June 30, 2024 and 2023, its statements of shareholders’ equity for the three and six months ended June 30, 2024 and 2023 and its consolidated cash flows for the six months ended June 30, 2024 and 2023.
These unaudited condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the accompanying notes for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K, filed with the Securities and Exchange Commission (the “SEC”) on February 28, 2024 (the “Annual Report”). The condensed consolidated balance sheet data as of December 31, 2023 presented for comparative purposes was derived from the Company’s audited consolidated financial statements but does not include all disclosures required by U.S. GAAP. The results for the three and six months ended June 30, 2024 are not necessarily indicative of the operating results to be expected for the full year or for any other subsequent interim period.
The Company’s significant accounting policies are disclosed in the audited consolidated financial statements for the year ended December 31, 2023 included in the Annual Report. There have been no changes to the Company's significant accounting policies since the date of the audited consolidated financial statements for the year ended December 31, 2023 included in the Annual Report.
Principles of Consolidation
These unaudited condensed consolidated financial statements of the Company include the accounts of the Company and its wholly-owned subsidiary, Repare Therapeutics USA Inc. (“Repare USA”), which was incorporated under the laws of Delaware on June 1, 2017. The financial statements of Repare USA are prepared for the same reporting period as the parent company, using consistent accounting policies. All intra-group transactions, balances, income, and expenses are eliminated in full upon consolidation.
Smaller Reporting Company
Repare qualifies as a “smaller reporting company” under the Exchange Act as of June 30, 2024 because the market value of its common shares held by non-affiliates was less than $200 million as of June 30, 2024. As a smaller reporting company, Repare may rely on exemptions from certain disclosure requirements that are available to smaller reporting companies. For so long as the Company remains a smaller reporting company, it is permitted and intends to rely on such exemptions from certain disclosure and other requirements that are applicable to other public companies that are not smaller reporting companies.
Use of Estimates
The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in consolidated financial statements and accompanying notes. Significant estimates and assumptions reflected in these unaudited condensed consolidated financial statements include, but are not limited to, estimates related to revenue recognition, accrued research and development expenses, share-based compensation and income taxes. The Company bases its estimates on historical experience and other market specific or other relevant assumptions that it believes to be reasonable under the
circumstances. Actual results could differ from those estimates. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known.
Recently Issued Accounting Pronouncements Not Yet Adopted
In November 2023, the FASB amended the guidance in ASU 280, Segment Reporting, to require a public entity to disclose significant segment expenses and other segment items on an annual and interim basis and provide in interim periods all disclosures about a reportable segment’s profit or loss and assets that are currently required annually. Public entities with a single reportable segment are required to provide the new disclosures and all the disclosures currently required under ASC 280. The new guidance is effective for public entities in fiscal years beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. The Company is currently assessing the impact of this amendment on its consolidated financial statements.
In December 2023, the FASB amended the guidance in ASU 740, Income Taxes, to provide disaggregated income tax disclosures on the rate reconciliation and income taxes paid. The new guidance is effective for public entities in fiscal years beginning after December 15, 2024. Early adoption is permitted. The Company is currently assessing the impact of this amendment on its consolidated financial statements.
3. Cash and Cash Equivalents and Marketable Securities
Cash and cash equivalents and marketable securities were comprised of the following:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
|
|
(in thousands) |
|
As of June 30, 2024 |
|
|
|
|
|
|
|
|
|
|
|
|
Cash and cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Cash |
|
$ |
44,565 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
44,565 |
|
Money market funds |
|
|
35,255 |
|
|
|
— |
|
|
|
— |
|
|
|
35,255 |
|
Total cash and cash equivalents: |
|
$ |
79,820 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
79,820 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
Commercial paper |
|
$ |
109,240 |
|
|
$ |
5 |
|
|
$ |
(106 |
) |
|
$ |
109,139 |
|
Corporate debt securities |
|
|
19,198 |
|
|
|
— |
|
|
|
(34 |
) |
|
|
19,164 |
|
Total marketable securities |
|
$ |
128,438 |
|
|
$ |
5 |
|
|
$ |
(140 |
) |
|
$ |
128,303 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
As of December 31, 2023 |
|
|
|
|
|
|
|
|
|
|
|
|
Cash and cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Cash |
|
$ |
44,462 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
44,462 |
|
Money market funds |
|
|
36,991 |
|
|
|
— |
|
|
|
— |
|
|
|
36,991 |
|
Commercial paper |
|
|
29,811 |
|
|
|
4 |
|
|
|
— |
|
|
|
29,815 |
|
Total cash and cash equivalents: |
|
$ |
111,264 |
|
|
$ |
4 |
|
|
$ |
— |
|
|
$ |
111,268 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury and government-sponsored enterprises |
|
$ |
22,434 |
|
|
$ |
— |
|
|
$ |
(25 |
) |
|
$ |
22,409 |
|
Commercial paper |
|
|
89,901 |
|
|
|
60 |
|
|
|
(11 |
) |
|
|
89,950 |
|
Total marketable securities |
|
$ |
112,335 |
|
|
$ |
60 |
|
|
$ |
(36 |
) |
|
$ |
112,359 |
|
Interest receivable was $0.4 million and $0.4 million as of June 30, 2024 and December 31, 2023, respectively, and is included in other current receivables.
The Company held available-for-sale marketable securities with an aggregate fair value of $103.5 million and $58.6 million that were in an immaterial, unrealized loss position as of June 30, 2024 and December 31, 2023, respectively, as shown in the table above. These marketable securities have been in an unrealized loss position for less than twelve months. The unrealized losses as of June 30, 2024 and December 31, 2023, were not attributed to credit risk but were primarily associated with changes in interest rates and market liquidity. The Company does not intend to sell these securities and it is more likely than not that it will hold these investments for a period of time sufficient to recover the amortized cost. As a result, the Company did not record an allowance for credit losses or other impairment charges for its marketable securities for the six months ended June 30, 2024 and 2023.
The Company recognized a net unrealized loss of nil and $0.2 million in other comprehensive (loss) income in the three months ended June 30, 2024 and 2023, respectively, and a net unrealized loss of $0.2 million and nil in the six months ended June 30, 2024 and 2023, respectively, in relation to its cash and cash equivalents and marketable securities.
The maturities of the Company’s marketable securities as of June 30, 2024 and December 31, 2023 are less than one year.
4. Fair Value Measurements
Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable:
•Level 1 – Quoted prices in active markets for identical assets or liabilities.
•Level 2 – Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data.
•Level 3 – Unobservable inputs that are supported by little or no market activity that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques.
The following table presents information about the Company’s financial assets measured at fair value on a recurring basis and indicates the level of the fair value hierarchy utilized to determine such fair values:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description |
|
Financial Assets |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
|
(in thousands) |
|
As of June 30, 2024 |
|
|
|
|
|
|
|
|
|
|
|
|
Assets |
|
|
|
|
|
|
|
|
|
|
|
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
35,255 |
|
|
$ |
35,255 |
|
|
$ |
— |
|
|
$ |
— |
|
Total cash equivalents |
|
|
35,255 |
|
|
|
35,255 |
|
|
|
— |
|
|
|
— |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
Commercial paper |
|
|
109,139 |
|
|
|
— |
|
|
|
109,139 |
|
|
|
— |
|
Corporate debt securities |
|
|
19,164 |
|
|
|
— |
|
|
|
19,164 |
|
|
|
— |
|
Total marketable securities |
|
|
128,303 |
|
|
|
— |
|
|
|
128,303 |
|
|
|
— |
|
Total financial assets |
|
$ |
163,558 |
|
|
$ |
35,255 |
|
|
$ |
128,303 |
|
|
$ |
— |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
As of December 31, 2023 |
|
|
|
|
|
|
|
|
|
|
|
|
Assets |
|
|
|
|
|
|
|
|
|
|
|
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
36,991 |
|
|
$ |
36,991 |
|
|
$ |
— |
|
|
$ |
— |
|
Commercial paper |
|
|
29,815 |
|
|
|
— |
|
|
|
29,815 |
|
|
|
— |
|
Total cash equivalents |
|
|
66,806 |
|
|
|
36,991 |
|
|
|
29,815 |
|
|
|
— |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury and government-sponsored enterprises |
|
|
22,409 |
|
|
|
— |
|
|
|
22,409 |
|
|
|
— |
|
Commercial paper |
|
|
89,950 |
|
|
|
— |
|
|
|
89,950 |
|
|
|
— |
|
Total marketable securities |
|
|
112,359 |
|
|
|
— |
|
|
|
112,359 |
|
|
|
— |
|
Total financial assets |
|
$ |
179,165 |
|
|
$ |
36,991 |
|
|
$ |
142,174 |
|
|
$ |
— |
|
When developing fair value estimates, the Company maximizes the use of observable inputs and minimizes the use of unobservable inputs. When available, the Company uses quoted market prices to measure the fair value. In determining the fair values at each date presented above, the Company relied on quoted prices for similar securities in active markets or using other inputs that are observable or can be corroborated by observable market data.
During the six months ended June 30, 2024, there were no transfers between fair value measure levels.
5. Accrued Expenses and Other Current Liabilities
Accrued expenses and other current liabilities consisted of the following:
|
|
|
|
|
|
|
|
|
|
|
As of June 30, 2024 |
|
|
As of December 31, 2023 |
|
|
|
(in thousands) |
|
Accrued research and development expense |
|
$ |
17,044 |
|
|
$ |
16,251 |
|
Accrued compensation and benefits |
|
|
4,376 |
|
|
|
6,981 |
|
Accrued professional services |
|
|
555 |
|
|
|
631 |
|
Other |
|
|
335 |
|
|
|
194 |
|
Total accrued expenses and other current liabilities |
|
$ |
22,310 |
|
|
$ |
24,057 |
|
6. Collaborative Arrangements
Debiopharm Clinical Study and Collaboration Agreement
In January 2024, the Company entered into a clinical study and collaboration agreement with Debiopharm International S.A. (“Debiopharm”), a privately-owned, Swiss-based biopharmaceutical company, with the aim to explore the synergy between the Company’s compound, lunresertib, and Debiopharm’s compound, Debio 0123, a WEE1 inhibitor (the “Debio Collaboration Agreement”). The Company and Debiopharm are collaborating on the development of a combination therapy, with the Company sponsoring the global study, and will share all costs equally. The Company and Debiopharm are each supplying their respective drugs and retain all commercial rights to their respective compounds, including as monotherapy or as combination therapies. The activities associated with the Debio Collaboration Agreement are coordinated by a joint steering committee, which is comprised of an equal number of representatives from the Company and Debiopharm.
Based on the terms of the Debio Collaboration Agreement, the Company concluded that the Debio Collaboration Agreement meets the requirements of a collaboration within the guidance of ASC 808, Collaborative Arrangements, as both parties are active participants in the combination trial and are exposed to significant risks and rewards depending on the success of the combination trial. Accordingly, the net costs associated with the co-development are expensed as incurred and recognized within research and development expenses in the consolidated statement of operations and comprehensive loss.
During the three and six months ended June 30, 2024, the Company recognized $0.9 million and $1.4 million, respectively, in net research and development costs with regards to the Debiopharm portion of the 50/50 cost sharing terms in the Debio Collaboration Agreement, and recorded a receivable from Debiopharm of $0.7 million as of June 30, 2024 in other current receivables.
7. Revenue recognition from Collaboration and License Agreements
The following table presents revenue from collaboration agreements:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Roche Collaboration and License Agreement |
|
$ |
1,073 |
|
|
$ |
4,825 |
|
|
$ |
50,888 |
|
|
$ |
10,137 |
|
Bristol-Myers Squibb Collaboration and License Agreement |
|
|
— |
|
|
|
14,951 |
|
|
|
2,589 |
|
|
|
15,317 |
|
Ono Collaboration Agreement |
|
|
— |
|
|
|
10,473 |
|
|
|
— |
|
|
|
10,473 |
|
Total revenue |
|
$ |
1,073 |
|
|
$ |
30,249 |
|
|
$ |
53,477 |
|
|
$ |
35,927 |
|
The Company’s revenue recognition accounting policy, as well as additional information on the Company’s collaboration and license agreements are disclosed in the audited consolidated financial statements for the year ended December 31, 2023 included in the Annual Report.
Roche Collaboration and License Agreement
In June 2022, the Company entered into a collaboration and license agreement (the “Roche Agreement”) with Hoffmann-La Roche Inc. and F. Hoffmann-La Roche Ltd (collectively, “Roche”) regarding the development and commercialization of the Company’s product candidate camonsertib (also known as RP-3500) and specified other Ataxia-Telangiectasia and Rad3-related protein kinase (“ATR”) inhibitors (the “Licensed Products”) which became effective July 13, 2022 (the “Effective Date”). Pursuant to the Roche
Agreement, the Company granted Roche a worldwide, perpetual, exclusive, sublicensable license to develop, manufacture, and commercialize the Licensed Products, as well as a non-exclusive, sublicensable license to certain related companion diagnostics. The Company agreed to complete specified ongoing clinical trials in accordance with the development plan in the Roche Agreement, as well as ongoing investigator sponsored trials (together, the “Continuing Trials”) at the Company’s expense. Roche assumed all subsequent development of camonsertib with the potential to expand development into additional tumors and multiple combination studies. The Company retained the right to conduct specified clinical trials (the “Repare Trials”) of camonsertib in combination with the Company’s PKMYT1 compound, lunresertib (also known as RP-6306). The Roche Agreement provided the Company, at its sole discretion, with the ability to opt-in to a 50/50 U.S. co-development and profit share arrangement, including participation in U.S. co-promotion if U.S. regulatory approval was received. If the Company chose to exercise its co-development and profit share option, it would continue to be eligible to receive certain clinical, regulatory, commercial and sales milestone payments, in addition to full ex-U.S. royalties.
On February 7, 2024, the Company received written notice from Roche of their election to terminate the Roche Agreement following a review of Roche’s pipeline and evolving external factors. The termination became effective May 7, 2024, at which time the Company regained global development and commercialization rights for camonsertib from Roche.
In February 2024, the Company received a $40.0 million milestone payment from Roche that was earned upon dosing of the first patient with camonsertib in Roche’s Phase 2 TAPISTRY trial in January 2024.
In March 2024, the Company received a further payment of $4.0 million for revisions to the clinical development plan under the Roche Agreement, of which $2.1 million was previously recorded as a receivable at December 31, 2023. The transaction price was updated for this additional consideration received, as well as other adjustments of $0.5 million pursuant to the termination of the agreement.
|
|
|
|
|
Deferred revenue pertaining to the Roche Agreement |
|
Completion of Continuing Trials |
|
|
|
(in thousands) |
|
Balance as of December 31, 2023 |
|
$ |
9,463 |
|
Increase in collaboration revenue |
|
|
41,425 |
|
Recognition as revenue, as the result of performance obligations satisfied |
|
|
(50,888 |
) |
Balance as of June 30, 2024 |
|
$ |
- |
|
The Company recognized $1.1 million and $4.8 million for the three months ended June 30, 2024 and 2023, respectively, and $50.9 million and $10.1 million for the six months ended June 30, 2024 and 2023, respectively, as revenue associated with the Roche Agreement in relation to (i) the recognition of revenue upon the $40.0 million milestone achievement in the first quarter of 2024, as well as (ii) the recognition of all remaining deferred revenue for research and development services performed towards the completion of the Continuing Trials during the period.
Bristol-Myers Squibb Collaboration and License Agreement
In May 2020, the Company entered into a collaboration and license agreement (the “BMS Agreement”) with Bristol-Myers Squibb Company (“Bristol-Myers Squibb”), pursuant to which the Company and Bristol-Myers Squibb have agreed to collaborate in the research and development of potential new product candidates for the treatment of cancer. The Company provided Bristol-Myers Squibb access to a selected number of its existing screening campaigns and novel campaigns. The Company was responsible for carrying out early-stage research activities directed to identifying potential targets for potential licensing by Bristol-Myers Squibb, in accordance with a mutually agreed upon research plan, and was solely responsible for such costs. The collaboration consisted of programs directed to both druggable targets and to targets commonly considered undruggable to traditional small molecule approaches. Upon Bristol-Myers Squibb’s election to exercise its option to obtain exclusive worldwide licenses for the subsequent development, manufacturing and commercialization of a program, Bristol-Myers Squibb will then be solely responsible for all such worldwide activities and costs.
Although the collaboration term expired in November 2023, the BMS Agreement will not expire until, on a licensed product-by-licensed product and country-by-country basis, the expiration of the applicable royalty term and in its entirety upon expiration of the last royalty term. Either party may terminate earlier upon an uncured material breach of the agreement by the other party, or the insolvency of the other party. Additionally, Bristol-Myers Squibb may terminate the BMS Agreement for any or no reason on a program-by-program basis upon specified written notice.
The Company is entitled to receive up to $301.0 million in total milestones on a program-by-program basis, consisting of $176.0 million in the aggregate for certain specified research, development and regulatory milestones and $125.0 million in the aggregate for
certain specified commercial milestones. The Company is further entitled to a tiered percentage royalty on annual net sales ranging from high-single digits to low-double digits, subject to certain specified reductions.
|
|
|
|
|
Deferred revenue pertaining to the BMS Agreement |
|
Options to license undruggable targets |
|
|
|
(in thousands) |
|
Balance as of December 31, 2023 |
|
$ |
2,489 |
|
Increase in collaboration revenue |
|
|
100 |
|
Recognition as revenue, as the result of performance obligations satisfied |
|
|
(2,589 |
) |
Balance as of June 30, 2024 |
|
$ |
— |
|
In March 2024, Bristol-Myers Squibb exercised its one remaining option for an undruggable target. As a result, the Company recognized $2.6 million as revenue related to undruggable targets, including the option fee payment of $0.1 million.
Ono Collaboration Agreement
In January 2019, the Company entered into a research services, license and collaboration agreement, (the “Ono Agreement”), with Ono Pharmaceutical Company Ltd., or (“Ono”), pursuant to which the Company and Ono agreed to collaborate in the research of potential product candidates targeting Polθ and the development of the Company’s small molecule Polθ inhibitor program. In June 2023, the Company and Ono determined not to further extend the term of the Ono Agreement. As a result, no product candidate would be licensed to Ono pursuant to the terms of the Ono Agreement. The Company recognized approximately $10.5 million as revenue for the three and six months ended June 30, 2023 with regards to the performance obligation under the Ono Agreement. The Company did not recognize any revenue pursuant to the Ono Agreement during the three and six months ended June 30, 2024.
8. Leases
The Company has historically entered into lease arrangements for its facilities. As of June 30, 2024, the Company had four operating leases with required future minimum payments. The Company’s leases generally do not include termination or purchase options.
Operating Leases
The following tables contain a summary of the lease costs recognized under ASC 842 and other information pertaining to the Company’s operating leases:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Operating Leases - Lease Costs |
|
|
|
|
|
|
|
|
|
|
|
|
Operating lease costs |
|
$ |
593 |
|
|
$ |
593 |
|
|
$ |
1,187 |
|
|
$ |
1,186 |
|
Short-term lease costs |
|
|
15 |
|
|
|
32 |
|
|
|
34 |
|
|
|
46 |
|
Variable lease costs |
|
|
83 |
|
|
|
60 |
|
|
|
168 |
|
|
|
100 |
|
Total lease costs |
|
$ |
691 |
|
|
$ |
685 |
|
|
$ |
1,389 |
|
|
$ |
1,332 |
|
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands, except as specified otherwise) |
|
Other Operating Lease Information |
|
|
|
|
|
|
Operating cash flows used for operating leases |
|
$ |
1,223 |
|
|
$ |
1,202 |
|
Right-of-use assets obtained in exchange for new operating lease liability |
|
$ |
— |
|
|
$ |
149 |
|
Weighted-average remaining lease term (in years) |
|
|
1.00 |
|
|
|
1.95 |
|
Weighted-average discount rate |
|
|
4.3 |
% |
|
|
4.1 |
% |
9. Share-Based Compensation
2020 Employee Share Purchase Plan
In June 2020, the Company’s board of directors adopted, and the Company’s shareholders approved the 2020 Employee Share Purchase Plan (“ESPP”). The number of shares reserved and available for issuance under the ESPP will automatically increase each January 1, beginning on January 1, 2021 and each January 1 thereafter through January 31, 2030, by the lesser of (1) 1.0% of the total number of common shares outstanding on December 31 of the preceding calendar year, (2) 3,300,000 common shares, or (3) such smaller number of common shares as the Company’s board of directors may designate.
The Company issued 60,618 common shares under the ESPP for the six months ended June 30, 2024, at a weighted-average price per share of $5.91, for aggregate proceeds of $0.4 million.
As of June 30, 2024, the number of common shares that may be issued under the ESPP is 1,772,568.
2020 Equity Inventive Plan
In June 2020, the Company’s board of directors adopted, and the Company’s shareholders approved the 2020 Equity Incentive Plan (the ”2020 Plan”). The 2020 Plan became effective on the effective date of the IPO, at which time the Company ceased making awards under the Option Plan. The 2020 Plan allows the Company’s compensation committee to make equity-based and cash-based incentive awards to the Company’s officers, employees, directors and consultants including but not limited to stock options and restricted share units. The aggregate number of common shares reserved and available for issuance under the 2020 Plan has automatically increased on January 1 of each year beginning on January 1, 2021 and will continue to increase on January 1 of each year through and including January 1, 2030, by 5% of the outstanding number of common shares on the immediately preceding December 31, or such lesser number of shares as determined by the Company’s board of directors.
As of June 30, 2024, the number of common shares reserved for issuance under the 2020 Plan is 12,144,106.
Inducement Plan
In April 2024, the Company’s board of directors approved the adoption of the 2024 Inducement Plan (the “Inducement Plan”), to be used exclusively for grants of awards to individuals who were not previously employees or directors (or following a bona fide period of non-employment) as a material inducement to such individuals’ entry into employment with the Company, pursuant to Nasdaq Listing Rule 5635(c)(4). The terms and conditions of the Inducement Plan are substantially similar to those of the 2020 Plan. 350,000 common shares have been reserved for issuance under the Inducement Plan.
Stock Options
The following table summarizes the Company’s stock options activity:
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average exercise price |
|
Outstanding, January 1, 2024 |
|
|
10,097,771 |
|
|
$ |
13.77 |
|
Granted |
|
|
1,621,082 |
|
|
$ |
6.48 |
|
Exercised |
|
|
(8,612 |
) |
|
$ |
1.99 |
|
Cancelled or forfeited |
|
|
(421,652 |
) |
|
$ |
14.02 |
|
Outstanding, June 30, 2024 |
|
|
11,288,589 |
|
|
$ |
12.72 |
|
The fair value of stock options, and the assumptions used in the Black Scholes option-pricing model to determine the grant date fair value of stock options granted to employees and non-employees were as follows, presented on a weighted average basis:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair value of stock options |
|
$ |
2.67 |
|
|
$ |
7.08 |
|
|
$ |
4.72 |
|
|
$ |
8.33 |
|
Risk-free interest rate |
|
|
4.30 |
% |
|
|
3.75 |
% |
|
|
4.21 |
% |
|
|
3.68 |
% |
Expected terms (in years) |
|
|
5.33 |
|
|
|
5.81 |
|
|
|
5.97 |
|
|
|
6.00 |
|
Expected volatility |
|
|
83.57 |
% |
|
|
80.78 |
% |
|
|
83.08 |
% |
|
|
81.48 |
% |
Expected dividend yield |
|
|
0.00 |
% |
|
|
0.00 |
% |
|
|
0.00 |
% |
|
|
0.00 |
% |
Restricted Share Units
The following table summarizes the Company’s restricted share unit activity:
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average grant date fair value |
|
Outstanding, January 1, 2024 |
|
|
603,685 |
|
|
$ |
12.42 |
|
Awarded |
|
|
527,273 |
|
|
$ |
6.95 |
|
Vested and released |
|
|
(200,262 |
) |
|
$ |
12.42 |
|
Forfeited |
|
|
(59,633 |
) |
|
$ |
11.34 |
|
Outstanding, June 30, 2024 |
|
|
871,063 |
|
|
$ |
9.18 |
|
The fair value of each restricted share unit is estimated on the date of grant based on the fair value of our common shares on that same date.
Share-Based Compensation
Share-based compensation expense for all awards was allocated as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Research and development |
|
$ |
3,694 |
|
|
$ |
3,329 |
|
|
$ |
7,113 |
|
|
$ |
6,548 |
|
General and administrative |
|
|
2,825 |
|
|
|
2,936 |
|
|
|
5,881 |
|
|
|
5,779 |
|
Total share-based compensation expense |
|
$ |
6,519 |
|
|
$ |
6,265 |
|
|
$ |
12,994 |
|
|
$ |
12,327 |
|
Share-based compensation expense by type of award was as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Stock options |
|
$ |
5,605 |
|
|
$ |
5,561 |
|
|
$ |
11,290 |
|
|
$ |
11,098 |
|
Restricted share units |
|
|
803 |
|
|
|
620 |
|
|
|
1,512 |
|
|
|
1,045 |
|
ESPP |
|
|
111 |
|
|
|
84 |
|
|
|
192 |
|
|
|
184 |
|
Total share-based compensation expense |
|
$ |
6,519 |
|
|
$ |
6,265 |
|
|
$ |
12,994 |
|
|
$ |
12,327 |
|
As of June 30, 2024, there was $31.3 million and $6.7 million of unrecognized share-based compensation expense to be recognized over a weighted average period of 1.4 years and 2.2 years related to unvested stock options and unvested restricted share units, respectively.
11. Net Loss per Share
The following table summarizes the computation of basic and diluted net loss per share attributable to common shareholders of the Company:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands, except share and per share amounts) |
|
Numerator: |
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
|
$ |
(34,774 |
) |
|
$ |
(11,946 |
) |
|
$ |
(21,612 |
) |
|
$ |
(46,887 |
) |
Denominator: |
|
|
|
|
|
|
|
|
|
|
|
|
Weighted-average common shares outstanding — basic and diluted |
|
|
42,445,462 |
|
|
|
42,089,530 |
|
|
|
42,339,732 |
|
|
|
42,065,237 |
|
Net loss per share - basic and diluted |
|
$ |
(0.82 |
) |
|
$ |
(0.28 |
) |
|
$ |
(0.51 |
) |
|
$ |
(1.11 |
) |
The Company excluded the following potential common shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common shareholders for the periods indicated because including them would have had an anti-dilutive effect:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Options to purchase common shares |
|
|
11,288,589 |
|
|
|
10,030,741 |
|
|
|
11,288,589 |
|
|
|
10,030,741 |
|
Restricted share units |
|
|
871,063 |
|
|
|
609,710 |
|
|
|
871,063 |
|
|
|
609,710 |
|
Estimated shares issuable under the ESPP |
|
|
78,964 |
|
|
|
48,316 |
|
|
|
78,964 |
|
|
|
48,316 |
|
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.
You should read the following discussion and analysis of our financial condition and results of operations together with (i) our unaudited condensed consolidated financial statements and related notes, appearing elsewhere in this Quarterly Report on Form 10-Q and (ii) the audited consolidated financial statements and related notes and management’s discussion and analysis of financial condition and results of operations for the fiscal year ended December 31, 2023 included in our Annual Report on Form 10-K (the “Annual Report”), filed with the Securities and Exchange Commission, (the “SEC”), on February 28, 2024. Some of the information contained in this discussion and analysis or set forth elsewhere in this Quarterly Report on Form 10-Q, including information with respect to our plans and strategy for our business and related financing, contains forward-looking statements that involve risks and uncertainties. As a result of many factors, including those factors set forth in the “Risk Factors” sections of this Quarterly Report on Form 10-Q and our Annual Report, our actual results could differ materially from the results described in or implied by the forward-looking statements contained in the following discussion and analysis.
Overview
We are a leading clinical-stage precision oncology company enabled by our proprietary synthetic lethality approach to the discovery and development of novel therapeutics. Synthetic lethality (“SL”) represents a clinically validated approach to drug development. We use our proprietary, genome-wide, CRISPR-enabled SNIPRx platform to systematically discover and develop highly targeted cancer therapies that preferentially treat cancers due to mechanisms of genomic instability, including DNA damage repair. SL arises when a deficiency in either of two genes is tolerated in cells, but simultaneous deficiencies in both genes cause cell death. Cancer cells that contain a mutation in one gene of a SL pair are susceptible to therapeutic intervention targeting the other gene pair.
Our Pipeline
Using our SNIPRx platform, we have internally developed four clinical or near-term clinical therapeutic candidates.
1.Lunresertib (RP-6306) is a first-in-class, selective and potent oral small molecule inhibitor of PKMYT1 (Protein Kinase Membrane-associated tyrosine- and threonine- specific cdc-2 inhibitory kinase), a cancer target we discovered and identified as synthetic lethal with cyclin E1 (“CCNE1”) amplification, or deleterious alterations in FBXW7 or PPP2R1A in solid tumors such as gynecological, colorectal and upper gastrointestinal malignancies. Lunresertib is currently the sole PKMYT1 inhibitor known to be in clinical trials and is being evaluated alone and in combinations across several clinical trials in the United States, United Kingdom, European Union and Canada.
We presented positive initial Phase 1 data from our ongoing Phase 1 MYTHIC trial demonstrating proof of concept for lunresertib alone and in combination with camonsertib at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in October 2023. Lunresertib was shown to be well tolerated, with a compelling safety profile. We further presented anti-tumor activity for lunresertib in combination with camonsertib. In the fourth quarter of 2024, we expect to provide updated MYTHIC data from ovarian and endometrial cancer expansion cohorts in approximately 20-30 patients each with the lunresertib and camonsertib combination. This data, if positive, may lead us to initiate a first pivotal trial in an indication for lunresertib and camonsertib in 2025. In the third quarter of 2023, we received Fast Track designation for lunresertib in combination with camonsertib for the treatment of adult patients with CCNE1 amplified, or
FBXW7 or PPP2R1A mutated endometrial cancer. In May 2024, we announced that an updated dosing schedule approach based on the patient’s entry hemoglobin level was agreed to by the U.S. Food and Drug Administration (the “FDA”) in March 2024, and results in improved tolerability of the lunresertib and camonsertib combination, reducing Grade 3 anemia from a reported level of 45% as of the data cut-off date of September 2023 to a reported level of 25% as of March 2024 in patients treated at the recommended Phase 2 dose and using the updated dosing schedule. The FDA has agreed with the recommended Phase 2 dose of lunresertib 80mg twice daily and camonsertib 80mg once daily for the MYTHIC trial. In June 2024, we were granted Fast-Track designation by the FDA for lunresertib in combination with camonsertib for the treatment of adult patients with CCNE1 amplified, or FBXW7 or PPP2R1A-mutated platinum-resistant ovarian cancer. In preparation for a potential registrational clinical trial start in 2025, we formed a collaboration with Foundation Medicine, Inc. to provide prospective genomic profiling to patients in the ongoing MYTHIC study of lunresertib alone or in combinations in genomically-defined patient populations. We are additionally exploring opportunities with Foundation Medicine to develop FoundationOne®CDx, a tissue-based comprehensive genomic profiling test, as a companion diagnostic for the lunresertib program.
We initiated additional Phase 1 combination clinical trials of lunresertib with gemcitabine (MAGNETIC) in December 2021 and with FOLFIRI (MINOTAUR) in August 2022. In May 2024, we announced preliminary safety data for MINOTAUR demonstrating no significant incremental toxicities for the lunresertib and FOLFIRI combination over FOLFIRI alone and an early signal with favorable tolerability in colorectal and other gastrointestinal tumors. We announced positive initial data from the ongoing Phase 1 MINOTAUR clinical trial at the European Society of Medical Oncology (“ESMO”) Gastrointestinal (GI) Cancers Congress in June 2024. In the fourth quarter of 2022, we received Fast Track designation for lunresertib in combination with gemcitabine for the treatment of adult patients with CCNE1 amplified, or FBXW7, or PPP2R1A mutated platinum resistant ovarian cancer. We are collaborating with the Canadian Cancer Trials Group in an ongoing basket Phase 2 Investigator Sponsored Clinical Trial (“IST”) that is enrolling patients with selected, advanced cancers receiving lunresertib as combination (NCT05605509). A sub-study to that protocol will evaluate lunresertib in combination with gemcitabine in patients with CDK4/6 inhibitor treated ER+/HER2- metastatic breast cancer (NCT05601440) was activated more recently and is also currently enrolling patients. We are also collaborating with University Health Network, Toronto on an investigator-sponsored Phase 1 clinical trial of lunresertib in combination with carboplatin and paclitaxel in TP53 ovarian and uterine cancer (NCT06107868) and such trial is currently enrolling patients.
In January 2024, we announced our collaboration with Debiopharm International S.A. (“Debiopharm”), a Swiss-based biopharmaceutical company. As part of this collaboration, we will sponsor a global trial as a new arm in the ongoing MYTHIC trial combining lunresertib with Debio 0123, a highly selective, brain penetrant, clinical WEE1 inhibitor. We announced the first patient was dosed with the synergistic lunresertib and Debio 0123 combination in April 2024. This is the first clinical trial inhibiting both PKMYT1 and WEE1. We expect to report initial data from this MYTHIC arm in 2025.
2.Camonsertib (RP-3500) is a potent and selective oral small molecule inhibitor of ATR (Ataxia-Telangiectasia and Rad3-related protein kinase) in clinical development for the treatment of solid tumors with specific DNA damage repair-related genomic alterations, including those in the ATM gene (ataxia telangiectasia mutated kinase).
We presented initial clinical data from the Phase 1/2 TRESR and ATTACC clinical trials evaluating camonsertib in combination with three poly (ADP-ribose) polymerase (PARP) inhibitors - talazoparib, niraparib, and olaparib. Camonsertib demonstrated 48% overall CBR in patients with advanced solid tumors across tumor types regardless of choice of PARP inhibitor or platinum resistance, with a favorable safety and tolerability profile.
In June 2022, we entered into a worldwide license and collaboration agreement with Hoffmann-La Roche Inc. and F. Hoffmann-La Roche Ltd (collectively “Roche”) for the development and commercialization of camonsertib, which resulted in an initial $125 million upfront payment. In February 2024, we received a $40 million milestone payment from Roche upon dosing of the first patient with camonsertib in Roche’s TAPISTRY trial. Since inception of the Roche camonsertib collaboration, we have received a cumulative total of $182.6 million, including the upfront payment, the milestone payment, as well as additional reimbursements from Roche. On February 7, 2024, we received written notice from Roche of their election to terminate the Roche camonsertib collaboration. The termination became effective in May 2024, at which time we regained global development and commercialization rights for camonsertib from Roche. We engaged in transition activities related to the termination in the first half of 2024 and announced an expansion of the TRESR clinical trial as a Phase 2 clinical trial evaluating camonsertib monotherapy in approximately 20 patients with ATM-mutated (“ATMm”) NSCLC, supported by early, promising camonsertib monotherapy signal in patients with ATMm NSCLC from the ongoing Phase 1/2 TRESR trial. We expect to report initial data from the TRESR trial in 2025.
3.RP-1664 is a first-in-class, highly selective, oral PLK4 inhibitor designed to harness the synthetic lethal relationship with TRIM37 amplification or overexpression in solid tumors. Tumors rely on PLK4 for centriole biogenesis in S-phase of the
cell cycle when TRIM37, an E3 ligase that reduces pericentriolar material, is high. Preclinical studies demonstrate that RP-1664 selectively inhibits PLK4 and drives potent synthetic lethality in TRIM37-high and other biomarkers tumor models, both in vitro and in vivo. Elevated TRIM37 is a feature found across a range of solid tumors and in approximately 80% of high-grade neuroblastoma. RP-1664 is the only selective PLK4 inhibitor known to be in the clinic.
We reported comprehensive preclinical data for RP-1664 in November 2023, including deep tumor growth inhibition and regressions in multiple TRIM37-high solid tumor or neuroblastoma xenograft models. The preclinical in vivo animal model evaluations were performed both internally and in collaboration with Children’s Hospital of Philadelphia. In February 2024, we dosed the first patient in the LIONS (PLK4 Inhibitor in Advanced Solid Tumors) clinical trial, a multicenter, open-label Phase 1 clinical trial to investigate safety, pharmacokinetics, pharmacodynamics and the preliminary efficacy of RP-1664. After evaluating safety in adult patients with recurrent solid tumors in the LIONS clinical trial, we expect to move into a Phase 1/2 clinical trial in patients with high risk, recurrent pediatric neuroblastoma, where the patients have limited treatment options and a high prevalence of TRIM37-altered tumors.
4.RP-3467 is a potential best-in-class inhibitor of adenosinetriphosphatase (“ATPase”) activity on the helicase domain of DNA polymerase theta (“Polθ”). Polθ is a synthetic lethal target associated with homologous recombination deficiency tumors, including those with BRCA1/2 mutations or other genomic alterations. Data suggest that RP-3467 works effectively and synergistically with therapies that result in double stranded DNA breaks, such as PARP inhibition, radioligand therapy and multiple chemotherapies and antibody-drug conjugates. Initial data suggest that Polθ inhibition may interfere with mechanisms central to the development of PARPi resistance, which could be relevant to currently marketed PARP 1/2 inhibitors and the emerging PARP1-selective inhibitors. We also reported comprehensive preclinical data for RP-3467 in November 2023, in which RP-3467 demonstrated complete, sustained regressions in combination with PARP inhibitors and compelling anti-tumor activity in combination with RLT and chemotherapy. We expect to initiate a Phase 1 clinical trial of RP-3467 in the second half of 2024.
Recent Developments
oCurrently evaluating lunresertib in combination with camonsertib in our MYTHIC dose expansion clinical trial at the recommended Phase 2 dose (RP2D) in patients with platinum-resistant ovarian and endometrial cancers harboring CCNE1 amplification or FBXW7 or PPP2R1A mutations, which are predictive of poor prognosis. We expect to report data from approximately 20-30 patients in each cohort in the fourth quarter of 2024.
oIn preparation for a potential registrational clinical trial start in 2025, we formed a collaboration with Foundation Medicine, Inc. to provide prospective genomic profiling for patients in the ongoing MYTHIC clinical trial. Additionally, we are exploring opportunities with Foundation Medicine to develop FoundationOne®CDx, a tissue-based comprehensive genomic profiling test, as a companion diagnostic for the lunresertib program.
oGranted Fast-Track designation by the FDA in June 2024 for lunresertib in combination with camonsertib for the treatment of adult patients with CCNE1 amplified, or FBXW7 or PPP2R1A-mutated platinum-resistant ovarian cancer.
oDosed the first patient in Module 4 of the ongoing MYTHIC clinical trial investigating lunresertib in combination with Debio 0123, an oral, brain-penetrant, highly selective WEE1 kinase inhibitor. We expect to report initial data from this module in 2025.
oAnnounced positive initial data from the ongoing Phase 1 MINOTAUR clinical trial evaluating lunresertib (RP-6306) in combination with FOLFIRI in patients with advanced solid tumors at the ESMO GI Cancers Congress in June 2024. The data showed the lunresertib combination therapy was well tolerated without excess toxicity above expected rates for lunresertib or standard FOLFIRI alone.
oDosed the first patient in the camonsertib monotherapy non-small cell lung cancer (NSCLC) expansion of the TRESR clinical trial. The NSCLC expansion is expected to enroll up to 20 patients with ATR-inhibitor sensitizing mutations in NSCLC to study the efficacy of camonsertib at the RP2D. We expect to report initial data from the TRESR trial in 2025.
oActively enrolling patients into the Phase 1 LIONS trial evaluating RP-1664 in adult and adolescent patients with TRIM37-high advanced solid tumors and other biomarkers. We expect to rapidly advance RP-1664 into a Phase 1/2
clinical trial in pediatric patients with high risk, recurrent neuroblastoma, where the patients have a high prevalence of TRIM37-altered tumors, after evaluating the safety profile in the LIONS trial.
oInitiation of a Phase 1 dose finding trial of RP-3467 is expected in the fourth quarter of 2024.
oWelcomed Steven H. Stein, M.D., Chief Medical Officer of Incyte Corporation, to our Board of Directors, effective as of June 17, 2024, the date of our 2024 annual meeting of shareholders. Effective as of the date of filing, Briggs Morrison, M.D. is stepping down from the Board after seven years of service.
Liquidity Overview
Since our inception in September 2016, we have focused primarily on raising capital, organizing and staffing our company, conducting discovery and research activities, identifying potential SL gene pairs, establishing and protecting our intellectual property portfolio including for our proprietary SNIPRx platform, developing and progressing our product candidates through preclinical studies and preparing for clinical trials and establishing arrangements with third parties for the manufacture of initial quantities of our product candidates and component materials.
As of June 30, 2024, we had cash and cash equivalents and marketable securities on hand of $208.1 million. We believe that our cash, cash equivalents, and marketable securities will be sufficient to fund our anticipated operating and capital expenditure requirements at least into mid-2026. We have based this estimate on assumptions that may prove to be wrong, and we could exhaust our capital resources sooner than we expect.
Since inception, we have incurred significant operating losses. Our net losses were $93.8 million and $29.0 million for the years ended December 31, 2023 and 2022, respectively, and $21.6 million for the six months ended June 30, 2024. As of June 30, 2024, we had an accumulated deficit of $354.7 million.
We expect to continue to incur significant and increasing expenses and operating losses for the foreseeable future as we advance our product candidates through preclinical and clinical development and seek regulatory approvals, manufacture drug product and drug supply, and maintain and expand our intellectual property portfolio. Our net losses are also expected to be impacted as we pay for accounting, audit, legal, regulatory and consulting services, and pay costs associated with maintaining compliance with Nasdaq listing rules and SEC requirements, directors and officers, or D&O, insurance, investor and public relations activities and other expenses associated with operating as a public company. Our net losses may fluctuate significantly from quarter-to-quarter and year-to-year, depending on the timing of our preclinical studies, our clinical trials, our expenditures on other research and development activities, and our revenue and expenses recognized from collaboration and license agreements.
We do not have any products approved for sale. We will not generate revenue from product sales unless and until we successfully complete clinical development and obtain regulatory approval for our product candidates, if ever. As a result, we will need substantial additional funding to support our continuing operations and pursue our growth strategy. Until we can generate significant revenue from product sales, if ever, we expect to finance our operations through a combination of public or private equity offerings and debt financings or other sources, such as potential collaboration agreements, strategic alliances and licensing arrangements. We may be unable to raise additional funds or enter into such other agreements or arrangements when needed on acceptable terms, or at all. Our failure to raise capital or enter into such agreements as, and when, needed, could have a negative effect on our business, results of operations and financial condition.
Macroeconomic Considerations
Unfavorable conditions in the economy in the United States, Canada and abroad may negatively affect the growth of our business and our results of operations. For example, macroeconomic events, including health pandemics, changes in inflation, interest rates and foreign currency exchange rates, banking crises or disruptions in access to bank deposits or lending commitments, natural disasters, geopolitical instability resulting from war, terrorism and other violence, as well as supply chain disruptions have led to economic uncertainty globally and could impact our overall business operations. The effect of macroeconomic conditions may not be fully reflected in our results of operations until future periods. If, however, economic uncertainty increases or the global economy worsens, our business, financial condition and results of operations may be harmed.
In addition, because some of our manufacturers and suppliers are located in China, we are exposed to the possibility of product supply disruption and increased costs in the event of changes in the policies, laws, rules and regulations of the United States or Chinese governments, as well as political unrest or unstable economic conditions in China. For example, trade tensions between the United States and China have been escalating in recent years. Most notably, several rounds of U.S. tariffs have been placed on Chinese goods being exported to the United States. Each of these U.S. tariff impositions against Chinese exports was followed by a round of retaliatory Chinese tariffs on U.S. exports to China. Our components may in the future be subject to these tariffs, which could increase our manufacturing costs and could make our products, if successfully developed and approved, less competitive than those of our competitors whose inputs are not subject to these tariffs. We may otherwise experience supply disruptions or delays, and although we carefully manage our supply and lead-times, our suppliers may not continue to provide us with clinical supply in our required quantities, to our required specifications and quality levels or at attractive prices. In addition, certain Chinese biotechnology companies and CMOs may become subject to trade restrictions, sanctions, other regulatory requirements, or proposed legislation by the U.S. government, which could restrict or even prohibit our ability to work with such entities, thereby potentially disrupting the supply of material to us. Such disruption could have adverse effects on the development of our product candidates and our business operations. In addition, the recently proposed BIOSECURE Act introduced in House of Representatives, as well as a substantially similar bill in the Senate, targets certain Chinese biotechnology companies. If these bills become law, or similar laws are passed, they would have the potential to severely restrict the ability of companies to contract with certain Chinese biotechnology companies of concern without losing the ability to contract with, or otherwise receive funding from, the U.S. government.
For further discussion of the potential impacts of macroeconomic events on our business, financial condition, and operating results, see the section titled “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2023.
Components of Results of Operations
Revenue
To date, we have not recognized any revenue from product sales, and we do not expect to generate any revenue from the sale of products in the foreseeable future. If our development efforts for our product candidates are successful and result in regulatory approval, or license agreements with third parties, we may generate revenue in the future from product sales. However, there can be no assurance as to when we will generate such revenue, if at all.
The following table presents revenue from our collaboration agreements:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Roche Collaboration and License Agreement |
|
$ |
1,073 |
|
|
$ |
4,825 |
|
|
$ |
50,888 |
|
|
$ |
10,137 |
|
Bristol-Myers Squibb Collaboration and License Agreement |
|
|
— |
|
|
|
14,951 |
|
|
|
2,589 |
|
|
|
15,317 |
|
Ono Collaboration Agreement |
|
|
— |
|
|
|
10,473 |
|
|
|
— |
|
|
|
10,473 |
|
Total revenue |
|
$ |
1,073 |
|
|
$ |
30,249 |
|
|
$ |
53,477 |
|
|
$ |
35,927 |
|
Collaboration and License Agreement with Hoffmann-La Roche Inc. and F. Hoffmann-La Roche Ltd
On June 1, 2022, we entered into a collaboration and license agreement, or the Roche Agreement, with Roche regarding the development and commercialization of our product candidate camonsertib (also known as RP-3500) and specified other ATR inhibitors, which we refer to as the Licensed Products.
Under the Roche Agreement, we granted Roche a worldwide, perpetual, exclusive, sublicensable license to develop, manufacture, and commercialize the Licensed Products. Roche assumed all subsequent development of camonsertib with the potential to expand development into additional tumors and multiple combination studies. We agreed to complete specified ongoing clinical trials in accordance with the development plan in the Roche Agreement, as well as ongoing investigator sponsored trials, or together, the Continuing Trials, at our expense. We also retained the right to conduct specified clinical trials of camonsertib in combination with our PKMYT1 compound (also known as RP-6306).
In February 2024, we received a $40 million milestone payment from Roche that was earned upon dosing of the first patient with camonsertib in Roche’s Phase 2 TAPISTRY trial in January 2024.
In March 2024, we received a further payment of $4.0 million for revisions to the clinical development plan under the Roche Agreement, of which $2.1 million was previously recorded as a receivable on our balance sheet at December 31, 2023.
|
|
|
|
|
Deferred revenue pertaining to the Roche Agreement |
|
Completion of Continuing Trials |
|
|
|
(in thousands) |
|
Balance as of December 31, 2023 |
|
$ |
9,463 |
|
Increase in collaboration revenue |
|
|
41,425 |
|
Recognition as revenue, as the result of performance obligations satisfied |
|
|
(50,888 |
) |
Balance as of June 30, 2024 |
|
$ |
- |
|
We recognized $1.1 million and $4.8 million for the three months ended June 30, 2024 and 2023, respectively, and $50.9 million and $10.1 million for the six months ended June 30, 2024 and 2023, respectively as revenue associated with the Roche Agreement in relation to (i) the recognition of revenue from the $40.0 million milestone achievement in the first quarter of 2024, as well as (ii) the recognition of all remaining deferred revenue for research and development services performed towards the completion of the Continuing Trials during the period.
On February 7, 2024, we received written notice from Roche of their election to terminate the Roche Agreement following a review of Roche’s pipeline and evolving external factors. The termination became effective May 7, 2024, at which time we regained global development and commercialization rights for camonsertib from Roche.
Collaboration and License Agreement with Bristol-Myers Squibb Company
In May 2020, we entered into a collaboration and license agreement, or the BMS Agreement, with the Bristol-Myers Squibb Company, or Bristol-Myers Squibb, pursuant to which we and Bristol-Myers Squibb have agreed to collaborate in the research and development of potential new product candidates for the treatment of cancer. We provided Bristol-Myers Squibb access to a selected number of our existing screening campaigns and novel campaigns. We were responsible for carrying out early-stage research activities directed to identifying potential targets for potential licensing by Bristol-Myers Squibb. The collaboration consisted of programs directed to both druggable targets and to targets commonly considered undruggable to traditional small molecule approaches. In the event that Bristol-Myers Squibb elects to obtain an exclusive license for the subsequent development, manufacturing and commercialization of a program, Bristol-Myers Squibb will then be solely responsible for all such worldwide activities.
Although the collaboration term expired in November 2023, the BMS Agreement will not expire until, on a licensed product-by-licensed product and country-by-country basis, the expiration of the applicable royalty term and in its entirety upon expiration of the last royalty term. Either party may terminate earlier upon an uncured material breach of the agreement by the other party, or the insolvency of the other party. Additionally, Bristol-Myers Squibb may terminate the BMS Agreement for any or no reason on a program-by-program basis upon specified written notice. We are eligible to receive up to $301.0 million in total milestones on a program-by-program basis, subject upon the achievement of certain specified research, development, regulatory and commercial milestones. We are further entitled to a tiered percentage royalty on annual net sales ranging from high-single digits to low-double digits, subject to certain specified reductions.
In March 2024, Bristol-Myers Squibb exercised its one remaining option for an undruggable target for a combined total of five druggable targets and one undruggable target over the course of the collaboration. As a result, we recognized the remaining deferred revenue of $2.6 million as revenue related to undruggable targets, including an option fee payment of $0.1 million.
Ono Collaboration Agreement
In January 2019, we entered into a research services, license and collaboration agreement, or the Ono Agreement, with Ono Pharmaceutical Company Ltd., or Ono, pursuant to which we and Ono agreed to collaborate in the research of potential product candidates targeting Polθ and the development of our small molecule Polθ inhibitor program. In June 2023, we and Ono determined not to further extend the Term of the Ono Agreement. As a result, no product candidate would be licensed to Ono pursuant to the terms of the Ono Agreement. We recognized approximately $10.5 million as revenue for the three and six months ended June 30, 2023 with
regards to the performance obligation under the Ono Agreement. We did not recognize any revenue pursuant to the Ono Agreement during the three and six months ended June 30, 2024.
Operating Expenses
Debiopharm Collaborative Arrangement
In January 2024, we entered into a clinical study and collaboration agreement, or the Debio Collaboration Agreement, with Debiopharm International S.A., or Debiopharm, a privately-owned, Swiss-based biopharmaceutical company, with the aim to explore the synergy between our compound, lunresertib, and Debiopharm’s compound, Debio 0123, a WEE1 inhibitor. We are collaborating with Debiopharm on the development of a combination therapy, with us sponsoring the global study, and will share all costs equally. Both parties are each supplying their respective drugs and retain all commercial rights to their respective compounds, including as monotherapy or as combination therapies. The activities associated with the Debio Collaboration Agreement are coordinated by a joint steering committee, which is comprised of an equal number of representatives from both parties.
Based on the terms of the Debio Collaboration Agreement, we concluded that the Debio Collaboration Agreement meets the requirements of a collaboration within the guidance of ASC 808, “Collaborative Arrangements”, as both parties are active participants in the combination trial and are exposed to significant risks and rewards depending on the success of the combination trial. Accordingly, the net costs associated with the co-development are expensed as incurred and recognized within research and development expenses in our consolidated statement of operations and comprehensive loss.
During the three and six months ended June 30, 2024, we recognized $0.9 million and $1.4 million, respectively, in net research and development costs with regards to the Debiopharm portion of the 50/50 cost sharing terms in the Debio Collaboration Agreement, and recorded a receivable from Debiopharm of $0.7 million as of June 30, 2024 in “other current receivables”.
Research and Development Expenses
Research and development expenses consist primarily of costs incurred for our research activities, including our drug discovery efforts and the development of our product candidates, partially offset by development cost reimbursements from collaborative arrangements and fully refundable Canadian research and development tax credits. We expense research and development costs as incurred, which include:
•external research and development expenses incurred under agreements with contract research organizations, or CROs, as well as investigative sites and consultants that conduct our clinical trials, preclinical studies and other scientific development services;
•employee-related expenses, including salaries, bonuses, benefits, share-based compensation, and other related costs for those employees involved in research and development efforts;
•costs related to manufacturing material for our preclinical studies and clinical trials, including fees paid to contract manufacturing organizations, or CMOs;
•laboratory supplies and research materials;
•upfront, milestone and maintenance fees incurred under license, acquisition and other third-party agreements;
•costs related to compliance with regulatory requirements; and
•facilities, depreciation, scientific advisory board and other allocated expenses, which include direct and allocated expenses for rent, maintenance of facilities and equipment, insurance, equipment and software.
Costs for certain activities are recognized based on an evaluation of the progress to completion of specific tasks using data such as information provided to us by our vendors and analyzing the progress of our studies or other services performed. Significant judgment and estimates are made in determining the accrued expense or prepaid balances at the end of any reporting period.
We characterize research and development costs incurred prior to the identification of a product candidate as discovery costs. We characterize costs incurred once a product candidate has been identified as development costs.
Our direct external research and development expenses consist primarily of fees paid to outside consultants, CROs, CMOs and research laboratories in connection with our preclinical development, process development, manufacturing and clinical development activities. Our direct external research and development expenses also include fees incurred under license, acquisition, and option
agreements. We track these external research and development costs on a program-by-program basis once we have identified a product candidate.
We do not allocate employee costs, costs associated with our discovery efforts, laboratory supplies, and facilities, including depreciation or other indirect costs, to specific programs because these costs are deployed across multiple programs and, as such, are not separately classified. We use internal resources primarily to conduct our research and discovery activities as well as for managing our preclinical development, process development, manufacturing, and clinical development activities.
The following table summarizes our research and development costs:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Discovery costs |
|
|
|
|
|
|
|
|
|
|
|
|
Direct external costs |
|
$ |
1,398 |
|
|
$ |
1,950 |
|
|
$ |
3,124 |
|
|
$ |
3,561 |
|
Laboratory supplies and research materials |
|
|
959 |
|
|
|
1,127 |
|
|
|
1,957 |
|
|
|
2,033 |
|
Personnel related costs |
|
|
3,232 |
|
|
|
3,141 |
|
|
|
6,418 |
|
|
|
6,263 |
|
Facilities related costs |
|
|
393 |
|
|
|
375 |
|
|
|
798 |
|
|
|
739 |
|
Other costs |
|
|
842 |
|
|
|
937 |
|
|
|
1,754 |
|
|
|
1,848 |
|
|
|
|
6,824 |
|
|
|
7,530 |
|
|
|
14,051 |
|
|
|
14,444 |
|
Development |
|
|
|
|
|
|
|
|
|
|
|
|
Direct external costs |
|
|
|
|
|
|
|
|
|
|
|
|
Camonsertib program* |
|
|
3,961 |
|
|
|
5,595 |
|
|
|
7,941 |
|
|
|
11,551 |
|
Lunresertib program* |
|
|
7,660 |
|
|
|
8,222 |
|
|
|
15,767 |
|
|
|
14,243 |
|
RP-1664 program |
|
|
1,412 |
|
|
|
2,002 |
|
|
|
3,008 |
|
|
|
3,300 |
|
RP-3467 and Polθ program |
|
|
773 |
|
|
|
1,273 |
|
|
|
2,328 |
|
|
|
3,024 |
|
Personnel related costs |
|
|
9,186 |
|
|
|
8,047 |
|
|
|
18,845 |
|
|
|
17,131 |
|
Facilities related costs |
|
|
213 |
|
|
|
215 |
|
|
|
421 |
|
|
|
417 |
|
Other costs* |
|
|
1,186 |
|
|
|
1,268 |
|
|
|
2,618 |
|
|
|
2,251 |
|
Debiopharm development cost reimbursement |
|
|
(880 |
) |
|
|
— |
|
|
|
(1,380 |
) |
|
|
— |
|
|
|
|
23,511 |
|
|
|
26,622 |
|
|
|
49,548 |
|
|
|
51,917 |
|
R&D tax credits |
|
|
(260 |
) |
|
|
(364 |
) |
|
|
(554 |
) |
|
|
(743 |
) |
Total research and development costs |
|
$ |
30,075 |
|
|
$ |
33,788 |
|
|
$ |
63,045 |
|
|
$ |
65,618 |
|
*Certain amounts have been reclassified for presentation purposes.
The successful development of our product candidates is highly uncertain. We plan to substantially increase our research and development expenses for the foreseeable future as we continue the development of our product candidates and manufacturing processes and conduct discovery and research activities for our preclinical programs. We cannot determine with certainty the timing of initiation, the duration, or the completion costs of current or future preclinical studies and clinical trials of our product candidates due to the inherently unpredictable nature of preclinical and clinical development. Clinical and preclinical development timelines, the probability of success and development costs can differ materially from expectations. We anticipate that we will make determinations as to which product candidates to pursue and how much funding to direct to each product candidate on an ongoing basis in response to the results of ongoing and future preclinical studies and clinical trials, regulatory developments, and our ongoing assessments as to each product candidate’s commercial potential. We will need to raise substantial additional capital in the future. Our clinical development costs are expected to increase significantly as we commence clinical trials. We anticipate that our expenses will increase substantially, particularly due to the numerous risks and uncertainties associated with developing product candidates, including the uncertainty of:
•the scope, rate of progress, and expenses of our ongoing research activities as well as any preclinical studies, clinical trials and other research and development activities;
•establishing an appropriate safety profile;
•successful enrollment in and completion of clinical trials;
•whether our product candidates show safety and efficacy in our clinical trials;
•receipt of marketing approvals from applicable regulatory authorities;
•establishing commercial manufacturing capabilities or making arrangements with third-party manufacturers;
•obtaining and maintaining patent and trade secret protection and regulatory exclusivity for our product candidates;
•commercializing product candidates, if and when approved, whether alone or in collaboration with others; and
•continued acceptable safety profile of products following any regulatory approval.
Any changes in the outcome of any of these variables with respect to the development of our product candidates in preclinical and clinical development could mean a significant change in the costs and timing associated with the development of these product candidates. We may never succeed in achieving regulatory approval for any of our product candidates. We may obtain unexpected results from our clinical trials. We may elect to discontinue, delay or modify clinical trials of some product candidates or focus on other product candidates. For example, if the FDA, the European Medicines Agency, (EMA), or another regulatory authority were to delay our planned start of clinical trials or require us to conduct clinical trials or other testing beyond those that we currently expect or if we experience significant delays in enrollment in any of our ongoing and planned clinical trials, we could be required to expend significant additional financial resources and time on the completion of clinical development of that product candidate.
General and Administrative Expenses
General and administrative expense consists primarily of employee related costs, including salaries, bonuses, benefits, share-based compensation and other related costs, as well as expenses for outside professional services, including legal, accounting and audit services and other consulting fees, rent expense, directors and officers insurance expenses, investor and public relations expenses and other general administrative expenses.
We anticipate that we will continue to incur significant accounting, audit, legal, regulatory, compliance and directors’ and officers’ insurance costs as well as investor and public relations expenses.
Other Income (Expense), Net
Other income (expense), net consists primarily of realized and unrealized gains and losses on foreign exchange, interest income earned on cash and cash equivalents and marketable securities, and other expenses such as interest and bank charges.
Realized and unrealized gains and losses on foreign exchange consist of realized and unrealized gains and losses from holding cash and foreign currency denominated other receivables, accounts payable, accrued expenses and other current liabilities as well as operating lease liabilities.
Results of Operations
Comparison of the Three Months Ended June 30, 2024 and 2023
The following table summarizes our results of operations for the three months ended June 30, 2024 and 2023:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
|
|
|
|
2024 |
|
|
2023 |
|
|
Change |
|
|
|
(in thousands) |
|
Revenue: |
|
|
|
|
|
|
|
|
|
Collaboration agreements |
|
$ |
1,073 |
|
|
$ |
30,249 |
|
|
$ |
(29,176 |
) |
Operating expenses: |
|
|
|
|
|
|
|
|
|
Research and development, net of tax credits |
|
|
30,075 |
|
|
|
33,788 |
|
|
|
(3,713 |
) |
General and administrative |
|
|
8,317 |
|
|
|
8,719 |
|
|
|
(402 |
) |
Total operating expenses |
|
|
38,392 |
|
|
|
42,507 |
|
|
|
(4,115 |
) |
Loss from operations |
|
|
(37,319 |
) |
|
|
(12,258 |
) |
|
|
(25,061 |
) |
Other income (expense), net |
|
|
|
|
|
|
|
|
|
Realized and unrealized gain (loss) on foreign exchange |
|
|
6 |
|
|
|
(41 |
) |
|
|
47 |
|
Interest income |
|
|
2,894 |
|
|
|
3,489 |
|
|
|
(595 |
) |
Other expense |
|
|
(29 |
) |
|
|
(26 |
) |
|
|
(3 |
) |
Total other income, net |
|
|
2,871 |
|
|
|
3,422 |
|
|
|
(551 |
) |
Loss before income taxes |
|
|
(34,448 |
) |
|
|
(8,836 |
) |
|
|
(25,612 |
) |
Income tax expense |
|
|
(326 |
) |
|
|
(3,110 |
) |
|
|
2,784 |
|
Net loss |
|
$ |
(34,774 |
) |
|
$ |
(11,946 |
) |
|
$ |
(22,828 |
) |
Revenue
Revenue was $1.1 million for the three months ended June 30, 2024, compared to $30.2 million for the three months ended June 30, 2023. The decrease of $29.1 million was primarily due to:
•a $3.7 million decrease in revenue recognized under the Roche Agreement in relation to the research and development services performed towards the completion of the Continuing Trials; and
•a $14.9 million decrease in revenue recognized under the BMS Agreement which expired in November 2023; and
•a $10.5 million decrease in revenue recognized under the Ono Agreement which expired in June 2023.
Research and Development Expenses, Net of Tax Credits
Research and development expenses were $30.1 million for the three months ended June 30, 2024, compared to $33.8 million for the three months ended June 30, 2023. The decrease of $3.7 million was primarily due to:
•a $1.6 million decrease in direct external costs of the camonsertib program as a result of the Phase 1/2 TRESR and ATTACC clinical trials which are fully enrolled and expected to be completed in 2024;
•a $1.7 million decrease in other direct external costs related to discovery programs ($0.6 million), the RP-1664 program ($0.6 million) and the RP-3467 program ($0.5 million);
•a $0.6 million decrease in direct external costs of the lunresertib program as a result of the Phase 1 Magnetic and Minotaur clinical trials which are fully enrolled;
•a $1.2 million increase in personnel-related costs, including a $0.4 million increase in share-based compensation; and
•a $0.9 million increase in the Debiopharm development cost reimbursement.
General and Administrative Expenses
General and administrative expenses were $8.3 million for the three months ended June 30, 2024, compared to $8.7 million for the three months ended June 30, 2023. The decrease of $0.4 million in general and administrative expenses consisted of:
•a $0.5 million decrease in our D&O insurance premium; and
•a $0.1 million increase in other general and administrative expenses.
Other Income (Expense), Net
Other income, net was $2.9 million and $3.4 million for the three months ended June 30, 2024 and 2023, respectively. The decrease of $0.5 million was primarily attributable to a decrease in cash and cash equivalents and marketable securities.
Income Tax Expense
Income tax expense were $0.3 million and $3.1 million for the three months ended June 30, 2024 and 2023, respectively. The decrease of $2.8 million was primarily due to the issuance of IRC Section 174 guidance on September 8, 2023.
Comparison of the Six Months Ended June 30, 2024 and 2023
The following table summarizes our results of operations for the six months ended June 30, 2024 and 2023:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
|
|
|
2024 |
|
|
2023 |
|
|
Change |
|
|
|
(in thousands) |
|
Revenue: |
|
|
|
|
|
|
|
|
|
Collaboration agreements |
|
$ |
53,477 |
|
|
$ |
35,927 |
|
|
$ |
17,550 |
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
Research and development, net of tax credits |
|
|
63,045 |
|
|
|
65,618 |
|
|
|
(2,573 |
) |
General and administrative |
|
|
16,935 |
|
|
|
17,248 |
|
|
|
(313 |
) |
Total operating expenses |
|
|
79,980 |
|
|
|
82,866 |
|
|
|
(2,886 |
) |
Loss from operations |
|
|
(26,503 |
) |
|
|
(46,939 |
) |
|
|
20,436 |
|
Other income (expense), net |
|
|
|
|
|
|
|
|
|
Realized and unrealized gain (loss) on foreign exchange |
|
|
37 |
|
|
|
(97 |
) |
|
|
134 |
|
Interest income |
|
|
5,862 |
|
|
|
6,916 |
|
|
|
(1,054 |
) |
Other expense |
|
|
(53 |
) |
|
|
(41 |
) |
|
|
(12 |
) |
Total other income, net |
|
|
5,846 |
|
|
|
6,778 |
|
|
|
(932 |
) |
Loss before income taxes |
|
|
(20,657 |
) |
|
|
(40,161 |
) |
|
|
19,504 |
|
Income tax expense |
|
|
(955 |
) |
|
|
(6,726 |
) |
|
|
5,771 |
|
Net loss |
|
$ |
(21,612 |
) |
|
$ |
(46,887 |
) |
|
$ |
25,275 |
|
Revenue
Revenue was $53.5 million for the six months ended June 30, 2024, compared to $35.9 million for the six months ended June 30, 2023. The increase of $17.6 million was due to:
•a $40.8 million increase in revenue recognized under the Roche Agreement as a result of the $40.0 million milestone achievement in the first quarter of 2024;
•a $12.7 million decrease in revenue recognized under the BMS Agreement which expired in November 2023; and
•a $10.5 million decrease in revenue recognized under the Ono Agreement which expired in June 2023.
Research and Development Expenses, Net of Tax Credits
Research and development expenses were $63.0 million for the six months ended June 30, 2024, compared to $65.6 million for the six months ended June 30, 2023. The decrease of $2.6 million was primarily due to:
•a $3.6 million decrease in direct external costs of the camonsertib program for the Phase 1/2 TRESR and ATTACC clinical trials that are fully enrolled and expected to be completed in 2024;
•a $1.4 million decrease in other direct external costs related to discovery programs ($0.4 million), the RP-1664 program ($0.3 million) and the RP-3467 program ($0.7 million);
•a $1.5 million increase in direct external costs with the advancement of clinical trials for lunresertib;
•a $0.4 million increase in other research and material expense including IT related costs;
•a $1.9 million increase in personnel-related costs, including a $0.6 million increase in share-based compensation; and
•a $1.4 million increase in the Debiopharm development cost reimbursement.
General and Administrative Expenses
General and administrative expenses were $16.9 million for the six months ended June 30, 2024, compared to $17.2 million for the six months ended June 30, 2023. The decrease of $0.3 million in general and administrative expenses consisted of:
•a $1.1 million decrease in our D&O insurance premium;
•a $0.5 million increase in personnel related costs, including a $0.1 million increase in share-based compensation; and
•a $0.3 million increase in other general and administrative expenses consisting mostly of costs related to IT and professional fees.
Other Income (Expense), Net
Other income, net was $5.8 million and $6.8 million for the six months ended June 30, 2024 and 2023, respectively. The decrease of $1.0 million was primarily attributable to a decrease in cash and cash equivalents and marketable securities.
Income Tax Expense
Income tax expense were $1.0 million and $6.7 million for the six months ended June 30, 2024 and 2023, respectively. The decrease of $5.7 million was primarily due to the issuance of IRC Section 174 guidance on September 8, 2023.
Liquidity and Capital Resources
Since our inception, we have not recognized any revenue from product sales and have incurred operating losses and negative cash flows from our operations. We have not yet commercialized any product and we do not expect to generate revenue from sales of any products for several years, if at all.
In June 2020, we completed our IPO whereby we raised $232.0 million, net of underwriting commissions and offering expenses. In November 2021, we completed a follow-on offering whereby we raised $94.3 million, net of underwriting commissions and offering expenses. Prior to our IPO, we had funded our operations primarily through equity financings, having raised an aggregate of approximately $135.2 million of gross proceeds from the sale of our preferred shares and $15.0 million of gross proceeds from the issuance of a warrant to acquire our common shares. We have also received initial upfront and additional payments of approximately $60.5 million in the aggregate from partnerships with Ono for our Polθ ATPase inhibitor program and Bristol-Myers Squibb for research and development of potential new product candidates for the treatment of cancer. In June 2022, we entered into a collaboration and license agreement with Roche for camonsertib and have received a cumulative total of $182.6 million to date under the terms of the Roche Agreement, including an upfront payment of $125.0 million, a milestone payment of $40 million and additional reimbursements from Roche.
In August 2022, we entered into a Common Shares Sale Agreement, or the Sales Agreement, with Cowen and Company, LLC. Under the Sales Agreement, we may sell up to $125.0 million in common shares. No shares have been issued under the Sales Agreement as of the date of this Quarterly Report on Form 10-Q.
We expect to incur significant expenses and operating losses for the foreseeable future as we advance our product candidates through preclinical and clinical development, seek regulatory approval and pursue commercialization of any approved product candidates and we will continue to incur additional costs associated with operating as a public company. We expect that our research and development and general and administrative costs will increase in connection with our planned research and development activities.
Beginning in 2022, the Tax Cuts and Jobs Act of 2017 eliminated the option to deduct certain U.S.-based research and development expenditures in the current fiscal year and required taxpayers to amortize them over five years pursuant to Section 174 of the Internal Revenue Code of 1986, as amended, or the IRC. This provision increased our 2023 and 2022 cash payments of income taxes significantly as compared to 2021 in compliance with IRC Section 174. In September 2023, new interim guidance was issued by the Department of Treasury and the Internal Revenue Service on IRC Section 174 that supports the deduction of such expenses. An income tax receivable in the amount of $12.1 million as of June 30, 2024 reflects the overpayment of tax installments by our U.S. subsidiary (net of a $4.8 million refund received in October 2023). Any changes to tax legislation may materially affect our cash flows. Changes in our tax provisions or an increase in our tax liabilities, whether due to changes in applicable laws and regulations or our interpretation or application thereof, could have a material adverse effect on our financial position, results of operations and/or cash flows.
As of June 30, 2024, our cash and cash equivalents and marketable securities on hand was $208.1 million. We believe that our existing cash and cash equivalents and marketable securities on hand will be sufficient to fund our anticipated operating and capital expenditure requirements at least into mid-2026. We have based this estimate on assumptions that may prove to be wrong, and we could exhaust our capital resources sooner than we expect.
Because of the numerous risks and uncertainties associated with research, development, and commercialization of our product candidates, we are unable to estimate the exact amount of our working capital requirements. Our future capital requirements will depend on many factors, including:
•the initiation, timing, costs, progress and results of our product candidates, including our ongoing Phase 1 clinical trials of lunresertib, camonsertib and RP-1664;
•the progress of preclinical development and possible clinical trials of our current earlier-stage programs;
•the scope, progress, results and costs of our research programs and preclinical development of any additional product candidates that we may pursue;
•the development requirements of other product candidates that we may pursue;
•our headcount growth and associated costs as we expand our research and development and establish a commercial infrastructure;
•the timing and amount of milestone and royalty payments that we are required to make or eligible to receive under our current or future collaboration agreements;
•the outcome, timing and cost of meeting regulatory requirements established by the FDA, EMA and other regulatory authorities;
•the costs and timing of future commercialization activities, including product manufacturing, marketing, sales and distribution, for any of our product candidates for which we or our collaborators receive marketing approval;
•the cost of expanding, maintaining and enforcing our intellectual property portfolio, including filing, prosecuting, defending and enforcing our patent claims and other intellectual property rights;
•the cost of defending potential intellectual property disputes, including patent infringement actions brought by third parties against us or any of our product candidates;
•the effect of competing technological and market developments;
•the cost and timing of completion of commercial-scale manufacturing activities;
•the extent to which we partner our programs, acquire or in-license other product candidates and technologies or enter into additional strategic collaborations;
•the revenue, if any, received from commercial sales of lunresertib, camonsertib and any future product candidates for which we or our collaborators receive marketing approval; and
•the costs of operating as a public company.
Until such time, if ever, as we can generate substantial product revenues to support our cost structure, we expect to finance our cash needs through a combination of equity offerings, debt financings, collaborations and other similar arrangements. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the ownership interest of our shareholders will be or could be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of our common shareholders. Debt financing and equity financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If we raise funds through collaborations, or other similar arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or product candidates or grant licenses on terms that may not be favorable to us and/or may reduce the value of our common shares. If we are unable to raise additional funds through equity or debt financings when needed, we may be required to delay, limit, reduce or terminate our product development or future commercialization efforts or grant rights to develop and market our product candidates even if we would otherwise prefer to develop and market such product candidates ourselves.
Cash Flows
Comparison of the Six Months Ended June 30, 2024 and 2023
The following table summarizes our cash flows for each of the periods presented:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
|
|
|
2024 |
|
|
2023 |
|
|
Change |
|
|
|
(in thousands) |
|
Net cash used in operating activities |
|
$ |
(18,582 |
) |
|
$ |
(66,132 |
) |
|
$ |
47,550 |
|
Net cash (used in) provided by investing activities |
|
|
(13,198 |
) |
|
|
21,664 |
|
|
|
(34,862 |
) |
Net cash provided by financing activities |
|
|
375 |
|
|
|
453 |
|
|
|
(78 |
) |
Effect of exchange rate fluctuations on cash held |
|
|
(43 |
) |
|
|
38 |
|
|
|
(81 |
) |
Net Decrease In Cash And Cash Equivalents |
|
$ |
(31,448 |
) |
|
$ |
(43,977 |
) |
|
$ |
12,529 |
|
Operating Activities
Net cash used in operating activities was $18.6 million for the six months ended June 30, 2024, reflecting a net loss of $21.6 million, a net change of $9.2 million in our net operating assets, offset by non-cash charges of $12.2 million. The non-cash charges primarily consist of share-based compensation for option and restricted share unit grants to employees, as well as depreciation expense, and non-cash lease expense offset by the net accretion of marketable securities. The change in our net operating assets was due to decreases of $12.0 million in deferred revenue, $1.7 million in accrued expenses and other current liabilities, $1.1 million in operating lease liability and $1.0 million in prepaid expenses, offset by increases of $0.9 million in other current receivables, $0.9 million in income taxes and $4.8 million in accounts payable.
Net cash used in operating activities was $66.1 million for the six months ended June 30, 2023, reflecting a net loss of $46.9 million, a net change of $29.7 million in our net operating assets, offset by non-cash charges of $10.5 million. The non-cash charges primarily consist of share-based compensation for option and restricted share unit grants to employees, as well as depreciation expense, and non-cash lease expense offset by the net accretion of marketable securities. The change in our net operating assets was primarily due to a decrease of $30.7 million in deferred revenue recognized during the six months ended June 30, 2023.
The $47.5 million increase in cash provided by operating activities for the six months ended June 30, 2024 compared to the six months ended June 30, 2023 is primarily due to the $40.0 million milestone payment from Roche in the first quarter of 2024.
Investing Activities
Net cash used in investing activities was $13.2 million for the six months ended June 30, 2024 and resulted primarily from the purchases of marketable securities offset by proceeds on maturities of marketable securities.
Net cash provided by investing activities was $21.7 million for the six months ended June 30, 2023 and resulted primarily from proceeds on maturities of marketable securities offset by the purchases of marketable securities and property and equipment.
Financing Activities
Net cash provided by financing activities was $0.4 million and $0.5 million for the six months ended June 30, 2024 and 2023, respectively, consisting primarily of net proceeds from the issuance of common shares under the ESPP.
Material Cash Requirements
There were no material changes to our material cash requirements during the six months ended June 30, 2024 from those described under “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in the Annual Report.
Critical Accounting Estimates
This management’s discussion and analysis is based on our unaudited condensed consolidated financial statements, which have been prepared in accordance with U.S. generally accepted accounting principles. The preparation of these unaudited condensed consolidated financial statements requires us to make judgments and estimates that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the unaudited condensed consolidated financial statements and the reported amounts of expenses during the reported periods. We base our estimates on historical experience, known trends and events, and various
other factors that we believe to be reasonable under the circumstances. Actual results may differ from these estimates under different assumptions or conditions. On an ongoing basis, we evaluate our judgments and estimates in light of changes in circumstances, facts, and experience. The effects of material revisions in estimates, if any, will be reflected in the consolidated financial statements prospectively from the date of change in estimates.
There have been no significant changes to our critical accounting estimates from those described in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” included in the Annual Report.
Recently Issued Accounting Pronouncements
See Note 2 to our unaudited condensed consolidated financial statements included in this Quarterly Report for a description of recent issued accounting pronouncements not yet adopted.
Item 3. Quantitative and Qualitative Disclosures About Market Risk.
We are exposed to certain risks in the ordinary course of our business. Market risk represents the risk of loss that may impact our financial position to adverse changes in financial market prices and rates. Our market risk exposure is primarily related to fluctuations in interest rates and foreign currency exchange rates.
Interest Rate Risk
Interest-earning instruments carry a degree of interest rate risk. In the six months ended June 30, 2024, we earned $5.9 million in interest income from cash balances held in cash and cash equivalents and marketable securities. As of June 30, 2024, we have a balance of $208.1 million in cash, money market funds, commercial paper and corporate debt securities. Our investment policy limits investment instruments to investment-grade securities with the objective to preserve capital and to maintain liquidity until the funds can be used in business operations. We do not have in place any tools to manage our interest rate risk. The risk of a sudden, significant change in market interest rates relative to the interest rates earned on our bank accounts and marketable securities having an impact on our results of operations or cash flows is limited owing to the relative short-term nature of these investments.
Foreign Currency Exchange Risk
Our reporting and functional currency is the U.S. dollar. Assets and liabilities denominated in currencies other than the U.S. dollar are translated into U.S. dollar at exchange rates in effect at each balance sheet date. Income items and expenses are translated using average exchange rate in effect for the relevant period.
We incur a portion of our expenses in Canadian dollars, as well as other currencies to a lesser extent. A change in the relative value of the U.S. dollar to the Canadian dollar and other currencies may negatively affect our results of operations, financial potion or cash flows. We have not engaged in the hedging of foreign currency transactions to date, although we may choose to do so in the future. We do, however, keep expected Canadian dollar cash requirements in Canadian dollars to form a natural hedge. We are exposed to currency risk through our cash, other current receivables, accounts payable, accrued expenses and other current liabilities, and operating lease liabilities denominated in Canadian dollars. Based on our Canadian dollar net exposure as of June 30, 2024, and assuming all other variables remain constant, a 10% depreciation in the relative value of the U.S. dollar to the Canadian dollar would result in a decrease of approximately $0.1 million in our net loss.
Item 4. Controls and Procedures.
Evaluation of Disclosure Controls and Procedures
We maintain “disclosure controls and procedures,” as defined in Rule 13a-15(e) and Rule 15d-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act, that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to our management, including our principal executive and principal financial officers, as appropriate to allow timely decisions regarding required disclosure.
Our management, with the participation of our Chief Executive Officer and our Chief Financial Officer, has evaluated the effectiveness of our disclosure controls and procedures as of June 30, 2024. Based upon that evaluation, our Chief Executive Officer and Chief Financial Officer have concluded that, as of such date, our disclosure controls and procedures are effective.
Changes in Internal Control over Financial Reporting
There were no changes in our internal control over financial reporting (as defined in Rule 13a-15(f) and 15d-15(f) under the Exchange Act that occurred during the period covered by this Quarterly Report on Form 10-Q that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
Inherent Limitations on Effectiveness of Controls
Our disclosure controls and procedures and internal control over financial reporting are designed to provide reasonable assurance of achieving the desired control objectives. Our management recognizes that any control system, no matter how well designed and operated, is based upon certain judgments and assumptions and cannot provide absolute assurance that its objectives will be met. Similarly, an evaluation of controls cannot provide absolute assurance that misstatements due to error or fraud will not occur or that all control issues and instances of fraud, if any, have been detected.
PART II—OTHER INFORMATION
Item 1. Legal Proceedings.
From time to time, we may become involved in legal proceedings arising in the ordinary course of our business. We are not currently a party to any material legal proceedings, and we are not aware of any pending or threatened legal proceeding against us that we believe could have an adverse effect on our business, operating results or financial condition.
Item 1A. Risk Factors.
Investing in our common shares involves a high degree of risk. In addition to the other information set forth in this Quarterly Report on Form 10-Q, you should carefully consider the risks described in the Annual Report, including the disclosure therein under Part I, Item 1A, "Risk Factors,” before deciding whether to invest in our common shares. These are not the only risks facing our business. Other risks and uncertainties that we are not currently aware of or that we currently consider immaterial also may materially adversely affect our business, financial condition and future results. Risks we have identified but currently consider immaterial could still also materially adversely affect our business, financial condition and future results of operations if our assumptions about those risks are incorrect or if circumstances change.
There were no material changes during the period covered in this Quarterly Report to the risk factors previously disclosed in Part I, Item 1A of the Annual Report, except as follows:
We are a “smaller reporting company” and we cannot be certain if the reduced reporting requirements applicable to smaller reporting companies will make our common shares less attractive to investors.
Because the market value of our common shares held by non-affiliates was less than $200 million as of June 30, 2024, we qualify as a “smaller reporting company” under the Exchange Act as of June 30, 2024. We may continue to be a smaller reporting company if either (i) the market value of our common shares held by non-affiliates is less than $250 million or (ii) our annual revenue was less than $100 million during the most recently completed fiscal year and the market value of our common shares held by non-affiliates is less than $700 million. As a smaller reporting company, we may rely on exemptions from certain disclosure requirements that are available to smaller reporting companies, including not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act and reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements. For so long as we remain a smaller reporting company, we are permitted and intend to rely on such exemptions from certain disclosure and other requirements that are applicable to other public companies that are not smaller reporting companies.
We cannot predict if investors will find our common shares less attractive because we may rely on the exemptions and reduced disclosure obligations applicable to smaller reporting companies. If some investors find our common shares less attractive as a result, there may be a less active trading market for our common shares and our share price may be more volatile.
If we fail to maintain an effective system of internal control over financial reporting, we may not be able to accurately report our financial results or prevent fraud. As a result, shareholders could lose confidence in our financial and other public reporting, which would harm our business and the trading price of our common shares.
We are subject to the reporting requirements of the Securities Exchange Act of 1934, as amended, or the Exchange Act, the Sarbanes-Oxley Act of 2002, or the Sarbanes-Oxley Act, as amended and the rules and regulations of The Nasdaq Global Market. Pursuant to Section 404 of the Sarbanes-Oxley Act, we are now required to perform system and process evaluation and testing of our internal control over financial reporting to allow our management to report on the effectiveness of our internal control over financial reporting. Furthermore, at such time we no longer qualify as a "smaller reporting company", our independent registered public accounting firm will be required to issue an annual report that attests the effectiveness of our internal control over financial reporting.
During the evaluation and testing process, if we identify one or more material weaknesses in our internal control over financial reporting, we will be unable to assert that our internal control over financial reporting is effective. Further, we may in the future discover weaknesses in our system of internal financial and accounting controls and procedures that could result in a material misstatement of our financial statements. Moreover, our internal controls over financial reporting will not prevent or detect all errors and all fraud. A control system, no matter how well designed and operated, can provide only reasonable, not absolute, assurance that the control system’s objectives will be met. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that misstatements due to error or fraud will not occur or that all control issues and instances of fraud will be detected.
If we are unable to assert that our internal control over financial reporting is effective, investors could lose confidence in the reliability of our financial statements, the market price of our common shares could decline and we could be subject to sanctions or investigations by The Nasdaq Global Market, the SEC or other regulatory authorities.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
(a) Recent Sales of Unregistered Securities
None.
(b) Issuer Purchases of Equity Securities
None.
Item 3. Defaults Upon Senior Securities.
None.
Item 4. Mine Safety Disclosures.
Not applicable.
Item 5. Other Information.
Trading Arrangements
During the three months ended June 30, 2024, none of our directors or officers (as defined in Rule 16a-1(f) under the Exchange Act) adopted or terminated contracts, instructions or written plans for the purchase or sale of our securities.
Item 6. Exhibits.
* Filed herewith.
** This certification is being furnished solely to accompany this Quarterly Report on Form 10-Q pursuant to 18 U.S.C. Section 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing of the registrant under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date hereof, regardless of any general incorporation language in such filing.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
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REPARE THERAPEUTICS INC. |
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Date: August 6, 2024 |
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By: |
/s/ Lloyd M. Segal |
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Lloyd M. Segal |
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President and Chief Executive Officer (Principal Executive Officer) |
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Date: August 6, 2024 |
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By: |
/s/ Steve Forte |
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Steve Forte |
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Executive Vice President, Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer) |
Exhibit 31.1
CERTIFICATION PURSUANT TO
SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, Lloyd M. Segal, certify that:
1.I have reviewed this Quarterly Report on Form 10-Q of Repare Therapeutics Inc.;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13(a)-15(f) and 15(d)-15(f)) for the registrant and have:
(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c)Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d)Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and
5.The registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):
(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and
(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.
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Date: August 6, 2024 |
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By: |
/s/ Lloyd M. Segal |
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Lloyd M. Segal |
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President and Chief Executive Officer (Principal Executive Officer) |
Exhibit 31.2
CERTIFICATION PURSUANT TO
SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, Steve Forte, certify that:
1.I have reviewed this Quarterly Report on Form 10-Q of Repare Therapeutics Inc.;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13(a)-15(f) and 15(d)-15(f)) for the registrant and have:
(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c)Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d)Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and
5.The registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):
(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and
(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.
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Date: August 6, 2024 |
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By: |
/s/ Steve Forte |
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Steve Forte |
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Executive Vice President, Chief Financial Officer (Principal Financial Officer) |
Exhibit 32.1
CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report on Form 10-Q of Repare Therapeutics Inc. (the “Company”) for the period ended June 30, 2024 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), Lloyd M. Segal, as President and Chief Executive Officer of the Company, and Steve Forte, as Executive Vice President and Chief Financial Officer of the Company, each hereby certifies, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that, to the best of his knowledge:
(1)The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
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Date: August 6, 2024 |
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/s/ Lloyd M. Segal |
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Lloyd M. Segal |
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President and Chief Executive Officer (Principal Executive Officer) |
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Date: August 6, 2024 |
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/s/ Steve Forte |
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Steve Forte |
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Executive Vice President, Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer) |
This certification accompanies the Form 10-Q to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before or after the date of the Form 10-Q), irrespective of any general incorporation language contained in such filing.
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v3.24.2.u1
Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
CURRENT ASSETS: |
|
|
Cash and cash equivalents |
$ 79,820
|
$ 111,268
|
Marketable securities |
128,303
|
112,359
|
Income tax receivable |
11,072
|
10,813
|
Other current receivables |
3,571
|
4,499
|
Prepaid expenses |
5,773
|
4,749
|
Total current assets |
228,539
|
243,688
|
Property and equipment, net |
3,226
|
4,215
|
Operating lease right-of-use assets |
2,195
|
3,326
|
Income tax receivable |
1,077
|
2,276
|
Other assets |
307
|
396
|
TOTAL ASSETS |
235,344
|
253,901
|
CURRENT LIABILITIES: |
|
|
Accounts payable |
7,182
|
2,400
|
Accrued expenses and other current liabilities |
22,310
|
24,057
|
Operating lease liability, current portion |
1,957
|
2,400
|
Deferred revenue, current portion |
0
|
10,222
|
Total current liabilities |
31,449
|
39,079
|
Operating lease liability, net of current portion |
218
|
1,010
|
Deferred revenue, net of current portion |
0
|
1,730
|
TOTAL LIABILITIES |
31,667
|
41,819
|
SHAREHOLDERS’ EQUITY |
|
|
Preferred shares, no par value per share; unlimited shares authorized as of June 30, 2024 and December 31,2023, respectively; 0 shares issued and outstanding as of June 30, 2024, and December 31, 2023, respectively |
0
|
0
|
Common shares, no par value per share; unlimited shares authorized as of June 30, 2024 and December 31, 2023; 42,445,533 and 42,176,041 shares issued and outstanding as of June 30, 2024 and December 31, 2023, respectively |
486,375
|
483,350
|
Additional paid-in capital |
72,157
|
61,813
|
Accumulated other comprehensive (loss) income |
(134)
|
28
|
Accumulated deficit |
(354,721)
|
(333,109)
|
Total shareholders’ equity |
203,677
|
212,082
|
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY |
$ 235,344
|
$ 253,901
|
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v3.24.2.u1
Condensed Consolidated Balance Sheets (Parenthetical) (Unaudited) - $ / shares
|
6 Months Ended |
12 Months Ended |
Jun. 30, 2024 |
Dec. 31, 2023 |
Statement of Financial Position [Abstract] |
|
|
Preferred stock par value |
$ 0
|
$ 0
|
Preferred stock shares authorized |
Unlimited
|
Unlimited
|
Preferred stock shares issued |
0
|
0
|
Preferred stock shares outstanding |
0
|
0
|
Common stock par value |
$ 0
|
$ 0
|
Common stock shares authorized |
Unlimited
|
Unlimited
|
Common stock shares issued |
42,445,533
|
42,176,041
|
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42,445,533
|
42,176,041
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v3.24.2.u1
Condensed Consolidated Statements of Operations and Comprehensive Income (Loss) (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Revenue: |
|
|
|
|
Collaboration agreements |
$ 1,073
|
$ 30,249
|
$ 53,477
|
$ 35,927
|
Operating expenses: |
|
|
|
|
Research and development, net of tax credits |
30,075
|
33,788
|
63,045
|
65,618
|
General and administrative |
8,317
|
8,719
|
16,935
|
17,248
|
Total operating expenses |
38,392
|
42,507
|
79,980
|
82,866
|
Loss from operations |
(37,319)
|
(12,258)
|
(26,503)
|
(46,939)
|
Other income (expense), net |
|
|
|
|
Realized and unrealized gain (loss) on foreign exchange |
6
|
(41)
|
37
|
(97)
|
Interest income |
2,894
|
3,489
|
5,862
|
6,916
|
Other expense |
(29)
|
(26)
|
(53)
|
(41)
|
Total other income, net |
2,871
|
3,422
|
5,846
|
6,778
|
Loss before income taxes |
(34,448)
|
(8,836)
|
(20,657)
|
(40,161)
|
Income tax expense |
(326)
|
(3,110)
|
(955)
|
(6,726)
|
Net loss |
(34,774)
|
(11,946)
|
(21,612)
|
(46,887)
|
Unrealized (loss) gain on available-for-sale marketable securities |
(21)
|
(189)
|
(162)
|
4
|
Total other comprehensive (loss) income |
(21)
|
(189)
|
(162)
|
4
|
Comprehensive loss |
$ (34,795)
|
$ (12,135)
|
$ (21,774)
|
$ (46,883)
|
Net loss per share attributable to common shareholders--basic |
$ (0.82)
|
$ (0.28)
|
$ (0.51)
|
$ (1.11)
|
Net loss per share attributable to common shareholders--diluted |
$ (0.82)
|
$ (0.28)
|
$ (0.51)
|
$ (1.11)
|
Weighted-average common shares outstanding-basic |
42,445,462
|
42,089,530
|
42,339,732
|
42,065,237
|
Weighted-average common shares outstanding-diluted |
42,445,462
|
42,089,530
|
42,339,732
|
42,065,237
|
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v3.24.2.u1
Condensed Consolidated Statements of Shareholders' Equity (Unaudited) - USD ($) $ in Thousands |
Total |
2020 Employee Share Purchase Plan |
Common Shares |
Common Shares
2020 Employee Share Purchase Plan
|
Additional Paid-in Capital |
Additional Paid-in Capital
2020 Employee Share Purchase Plan
|
Accumulated Other Comprehensive Income (Loss) |
Accumulated Deficit |
Balance at Dec. 31, 2022 |
$ 279,517
|
|
$ 482,032
|
|
$ 37,226
|
|
$ (428)
|
$ (239,313)
|
Balance, Shares at Dec. 31, 2022 |
|
|
42,036,193
|
|
|
|
|
|
Share-based compensation expense |
6,062
|
|
|
|
6,062
|
|
|
|
Exercise of stock options |
4
|
|
$ 7
|
|
(3)
|
|
|
|
Exercise of stock options, Shares |
|
|
2,000
|
|
|
|
|
|
Issuance of common shares under the 2020 Employee Share Purchase Plan |
|
$ 409
|
|
$ 638
|
|
$ (229)
|
|
|
Issuance of common shares under the 2020 Employee Share Purchase Plan, Shares |
|
|
|
41,703
|
|
|
|
|
Other comprehensive income (loss) |
193
|
|
|
|
|
|
193
|
|
Net income (loss) |
(34,941)
|
|
|
|
|
|
|
(34,941)
|
Balance at Mar. 31, 2023 |
251,244
|
|
$ 482,677
|
|
43,056
|
|
(235)
|
(274,254)
|
Balance, Shares at Mar. 31, 2023 |
|
|
42,079,896
|
|
|
|
|
|
Share-based compensation expense |
6,265
|
|
|
|
6,265
|
|
|
|
Exercise of stock options |
40
|
|
$ 62
|
|
(22)
|
|
|
|
Exercise of stock options, Shares |
|
|
14,050
|
|
|
|
|
|
Other comprehensive income (loss) |
(189)
|
|
|
|
|
|
(189)
|
|
Net income (loss) |
(11,946)
|
|
|
|
|
|
|
(11,946)
|
Balance at Jun. 30, 2023 |
245,414
|
|
$ 482,739
|
|
49,299
|
|
(424)
|
(286,200)
|
Balance, Shares at Jun. 30, 2023 |
|
|
42,093,946
|
|
|
|
|
|
Balance at Dec. 31, 2023 |
212,082
|
|
$ 483,350
|
|
61,813
|
|
28
|
(333,109)
|
Balance, Shares at Dec. 31, 2023 |
|
|
42,176,041
|
|
|
|
|
|
Share-based compensation expense |
6,475
|
|
|
|
6,475
|
|
|
|
Exercise of stock options |
17
|
|
$ 27
|
|
(10)
|
|
|
|
Exercise of stock options, Shares |
|
|
8,485
|
|
|
|
|
|
Issuance of common shares on vesting of restricted share units |
|
|
$ 2,488
|
|
(2,488)
|
|
|
|
Issuance of common shares on vesting of restricted share units , Shares |
|
|
200,262
|
|
|
|
|
|
Issuance of common shares under the 2020 Employee Share Purchase Plan |
|
$ 358
|
|
$ 510
|
|
$ (152)
|
|
|
Issuance of common shares under the 2020 Employee Share Purchase Plan, Shares |
|
|
|
60,618
|
|
|
|
|
Other comprehensive income (loss) |
(141)
|
|
|
|
|
|
(141)
|
|
Net income (loss) |
13,162
|
|
|
|
|
|
|
13,162
|
Balance at Mar. 31, 2024 |
231,953
|
|
$ 486,375
|
|
65,638
|
|
(113)
|
(319,947)
|
Balance, Shares at Mar. 31, 2024 |
|
|
42,445,406
|
|
|
|
|
|
Balance at Dec. 31, 2023 |
$ 212,082
|
|
$ 483,350
|
|
61,813
|
|
28
|
(333,109)
|
Balance, Shares at Dec. 31, 2023 |
|
|
42,176,041
|
|
|
|
|
|
Exercise of stock options, Shares |
8,612
|
|
|
|
|
|
|
|
Balance at Jun. 30, 2024 |
$ 203,677
|
|
$ 486,375
|
|
72,157
|
|
(134)
|
(354,721)
|
Balance, Shares at Jun. 30, 2024 |
|
|
42,445,533
|
|
|
|
|
|
Balance at Mar. 31, 2024 |
231,953
|
|
$ 486,375
|
|
65,638
|
|
(113)
|
(319,947)
|
Balance, Shares at Mar. 31, 2024 |
|
|
42,445,406
|
|
|
|
|
|
Share-based compensation expense |
6,519
|
|
|
|
6,519
|
|
|
|
Exercise of stock options, Shares |
|
|
127
|
|
|
|
|
|
Other comprehensive income (loss) |
(21)
|
|
|
|
|
|
(21)
|
|
Net income (loss) |
(34,774)
|
|
|
|
|
|
|
(34,774)
|
Balance at Jun. 30, 2024 |
$ 203,677
|
|
$ 486,375
|
|
$ 72,157
|
|
$ (134)
|
$ (354,721)
|
Balance, Shares at Jun. 30, 2024 |
|
|
42,445,533
|
|
|
|
|
|
X |
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v3.24.2.u1
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Cash Flows From Operating Activities: |
|
|
Net loss for the period |
$ (21,612)
|
$ (46,887)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Share-based compensation expense |
12,994
|
12,327
|
Depreciation expense |
989
|
947
|
Non-cash lease expense |
1,131
|
1,086
|
Foreign exchange (gain) loss |
(27)
|
60
|
Net accretion of marketable securities |
(2,908)
|
(3,928)
|
Changes in operating assets and liabilities: |
|
|
Prepaid expenses |
(1,024)
|
1,518
|
Other current receivables |
910
|
(988)
|
Other non-current assets |
89
|
89
|
Accounts payable |
4,785
|
4,429
|
Accrued expenses and other current liabilities |
(1,731)
|
(17)
|
Operating lease liability, current portion |
(401)
|
72
|
Income taxes |
940
|
(2,991)
|
Operating lease liability, net of current portion |
(765)
|
(1,172)
|
Deferred revenue |
(11,952)
|
(30,677)
|
Net cash used in operating activities |
(18,582)
|
(66,132)
|
Cash Flows From Investing Activities: |
|
|
Purchases of property and equipment |
0
|
(1,540)
|
Proceeds from maturities of marketable securities |
89,015
|
169,000
|
Purchase of marketable securities |
(102,213)
|
(145,796)
|
Net cash provided by (used in) investing activities |
(13,198)
|
21,664
|
Cash Flows From Financing Activities: |
|
|
Proceeds from exercise of stock options |
17
|
44
|
Proceeds from issuance of common stock under the 2020 Employee Share Purchase Plan |
358
|
409
|
Net cash provided by financing activities |
375
|
453
|
Effect of exchange rate fluctuations on cash held |
(43)
|
38
|
Net Decrease In Cash And Cash Equivalents |
(31,448)
|
(43,977)
|
Cash and cash equivalents at beginning of period |
111,268
|
159,521
|
Cash and cash equivalents at end of period |
79,820
|
115,544
|
Supplemental Disclosure Of Cash Flow Information: |
|
|
Right-of-use asset obtained in exchange for new operating lease liability |
$ 0
|
$ 149
|
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v3.24.2.u1
Pay vs Performance Disclosure - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Pay vs Performance Disclosure |
|
|
|
|
Net Income (Loss) |
$ (34,774)
|
$ (11,946)
|
$ (21,612)
|
$ (46,887)
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v3.24.2.u1
Organization and Nature of Business
|
6 Months Ended |
Jun. 30, 2024 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Organization and Nature of Business |
1. Organization and Nature of Business Repare Therapeutics Inc. (“Repare” or the “Company”) is a precision medicine oncology company focused on the development of synthetic lethality-based therapies for patients with cancer. The Company is governed by the Business Corporations Act (Québec). The Company’s common shares are listed on the Nasdaq Global Select Market under the ticker symbol “RPTX”.
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v3.24.2.u1
Summary of Significant Accounting Policies
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Summary of Significant Accounting Policies |
2. Summary of Significant Accounting Policies Basis of Presentation The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America (“U.S. GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and as amended by Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). The unaudited condensed consolidated financial statements have been prepared on the same basis as the audited annual consolidated financial statements as of and for the year ended December 31, 2023, and, in the opinion of management, reflect all adjustments, consisting of normal recurring adjustments, necessary for the fair presentation of the Company’s consolidated financial position as of June 30, 2024, the consolidated results of its operations for the three and six months ended June 30, 2024 and 2023, its statements of shareholders’ equity for the three and six months ended June 30, 2024 and 2023 and its consolidated cash flows for the six months ended June 30, 2024 and 2023. These unaudited condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the accompanying notes for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K, filed with the Securities and Exchange Commission (the “SEC”) on February 28, 2024 (the “Annual Report”). The condensed consolidated balance sheet data as of December 31, 2023 presented for comparative purposes was derived from the Company’s audited consolidated financial statements but does not include all disclosures required by U.S. GAAP. The results for the three and six months ended June 30, 2024 are not necessarily indicative of the operating results to be expected for the full year or for any other subsequent interim period. The Company’s significant accounting policies are disclosed in the audited consolidated financial statements for the year ended December 31, 2023 included in the Annual Report. There have been no changes to the Company's significant accounting policies since the date of the audited consolidated financial statements for the year ended December 31, 2023 included in the Annual Report. Principles of Consolidation These unaudited condensed consolidated financial statements of the Company include the accounts of the Company and its wholly-owned subsidiary, Repare Therapeutics USA Inc. (“Repare USA”), which was incorporated under the laws of Delaware on June 1, 2017. The financial statements of Repare USA are prepared for the same reporting period as the parent company, using consistent accounting policies. All intra-group transactions, balances, income, and expenses are eliminated in full upon consolidation. Smaller Reporting Company Repare qualifies as a “smaller reporting company” under the Exchange Act as of June 30, 2024 because the market value of its common shares held by non-affiliates was less than $200 million as of June 30, 2024. As a smaller reporting company, Repare may rely on exemptions from certain disclosure requirements that are available to smaller reporting companies. For so long as the Company remains a smaller reporting company, it is permitted and intends to rely on such exemptions from certain disclosure and other requirements that are applicable to other public companies that are not smaller reporting companies. Use of Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in consolidated financial statements and accompanying notes. Significant estimates and assumptions reflected in these unaudited condensed consolidated financial statements include, but are not limited to, estimates related to revenue recognition, accrued research and development expenses, share-based compensation and income taxes. The Company bases its estimates on historical experience and other market specific or other relevant assumptions that it believes to be reasonable under the circumstances. Actual results could differ from those estimates. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. Recently Issued Accounting Pronouncements Not Yet Adopted In November 2023, the FASB amended the guidance in ASU 280, Segment Reporting, to require a public entity to disclose significant segment expenses and other segment items on an annual and interim basis and provide in interim periods all disclosures about a reportable segment’s profit or loss and assets that are currently required annually. Public entities with a single reportable segment are required to provide the new disclosures and all the disclosures currently required under ASC 280. The new guidance is effective for public entities in fiscal years beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. The Company is currently assessing the impact of this amendment on its consolidated financial statements. In December 2023, the FASB amended the guidance in ASU 740, Income Taxes, to provide disaggregated income tax disclosures on the rate reconciliation and income taxes paid. The new guidance is effective for public entities in fiscal years beginning after December 15, 2024. Early adoption is permitted. The Company is currently assessing the impact of this amendment on its consolidated financial statements.
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- DefinitionThe entire disclosure for all significant accounting policies of the reporting entity.
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v3.24.2.u1
Cash and Cash Equivalents and Marketable Securities
|
6 Months Ended |
Jun. 30, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
Cash and Cash Equivalents and Marketable Securities |
3. Cash and Cash Equivalents and Marketable Securities Cash and cash equivalents and marketable securities were comprised of the following:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
|
|
(in thousands) |
|
As of June 30, 2024 |
|
|
|
|
|
|
|
|
|
|
|
|
Cash and cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Cash |
|
$ |
44,565 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
44,565 |
|
Money market funds |
|
|
35,255 |
|
|
|
— |
|
|
|
— |
|
|
|
35,255 |
|
Total cash and cash equivalents: |
|
$ |
79,820 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
79,820 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
Commercial paper |
|
$ |
109,240 |
|
|
$ |
5 |
|
|
$ |
(106 |
) |
|
$ |
109,139 |
|
Corporate debt securities |
|
|
19,198 |
|
|
|
— |
|
|
|
(34 |
) |
|
|
19,164 |
|
Total marketable securities |
|
$ |
128,438 |
|
|
$ |
5 |
|
|
$ |
(140 |
) |
|
$ |
128,303 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
As of December 31, 2023 |
|
|
|
|
|
|
|
|
|
|
|
|
Cash and cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Cash |
|
$ |
44,462 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
44,462 |
|
Money market funds |
|
|
36,991 |
|
|
|
— |
|
|
|
— |
|
|
|
36,991 |
|
Commercial paper |
|
|
29,811 |
|
|
|
4 |
|
|
|
— |
|
|
|
29,815 |
|
Total cash and cash equivalents: |
|
$ |
111,264 |
|
|
$ |
4 |
|
|
$ |
— |
|
|
$ |
111,268 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury and government-sponsored enterprises |
|
$ |
22,434 |
|
|
$ |
— |
|
|
$ |
(25 |
) |
|
$ |
22,409 |
|
Commercial paper |
|
|
89,901 |
|
|
|
60 |
|
|
|
(11 |
) |
|
|
89,950 |
|
Total marketable securities |
|
$ |
112,335 |
|
|
$ |
60 |
|
|
$ |
(36 |
) |
|
$ |
112,359 |
|
Interest receivable was $0.4 million and $0.4 million as of June 30, 2024 and December 31, 2023, respectively, and is included in other current receivables. The Company held available-for-sale marketable securities with an aggregate fair value of $103.5 million and $58.6 million that were in an immaterial, unrealized loss position as of June 30, 2024 and December 31, 2023, respectively, as shown in the table above. These marketable securities have been in an unrealized loss position for less than twelve months. The unrealized losses as of June 30, 2024 and December 31, 2023, were not attributed to credit risk but were primarily associated with changes in interest rates and market liquidity. The Company does not intend to sell these securities and it is more likely than not that it will hold these investments for a period of time sufficient to recover the amortized cost. As a result, the Company did not record an allowance for credit losses or other impairment charges for its marketable securities for the six months ended June 30, 2024 and 2023. The Company recognized a net unrealized loss of nil and $0.2 million in other comprehensive (loss) income in the three months ended June 30, 2024 and 2023, respectively, and a net unrealized loss of $0.2 million and nil in the six months ended June 30, 2024 and 2023, respectively, in relation to its cash and cash equivalents and marketable securities. The maturities of the Company’s marketable securities as of June 30, 2024 and December 31, 2023 are less than one year.
|
X |
- DefinitionThe entire disclosure of cash, cash equivalents, and debt and equity securities, including any unrealized or realized gain (loss).
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v3.24.2.u1
Fair Value Measurements
|
6 Months Ended |
Jun. 30, 2024 |
Fair Value Disclosures [Abstract] |
|
Fair Value Measurements |
4. Fair Value Measurements Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable: •Level 1 – Quoted prices in active markets for identical assets or liabilities. •Level 2 – Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data. •Level 3 – Unobservable inputs that are supported by little or no market activity that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques. The following table presents information about the Company’s financial assets measured at fair value on a recurring basis and indicates the level of the fair value hierarchy utilized to determine such fair values:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description |
|
Financial Assets |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
|
(in thousands) |
|
As of June 30, 2024 |
|
|
|
|
|
|
|
|
|
|
|
|
Assets |
|
|
|
|
|
|
|
|
|
|
|
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
35,255 |
|
|
$ |
35,255 |
|
|
$ |
— |
|
|
$ |
— |
|
Total cash equivalents |
|
|
35,255 |
|
|
|
35,255 |
|
|
|
— |
|
|
|
— |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
Commercial paper |
|
|
109,139 |
|
|
|
— |
|
|
|
109,139 |
|
|
|
— |
|
Corporate debt securities |
|
|
19,164 |
|
|
|
— |
|
|
|
19,164 |
|
|
|
— |
|
Total marketable securities |
|
|
128,303 |
|
|
|
— |
|
|
|
128,303 |
|
|
|
— |
|
Total financial assets |
|
$ |
163,558 |
|
|
$ |
35,255 |
|
|
$ |
128,303 |
|
|
$ |
— |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
As of December 31, 2023 |
|
|
|
|
|
|
|
|
|
|
|
|
Assets |
|
|
|
|
|
|
|
|
|
|
|
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
36,991 |
|
|
$ |
36,991 |
|
|
$ |
— |
|
|
$ |
— |
|
Commercial paper |
|
|
29,815 |
|
|
|
— |
|
|
|
29,815 |
|
|
|
— |
|
Total cash equivalents |
|
|
66,806 |
|
|
|
36,991 |
|
|
|
29,815 |
|
|
|
— |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury and government-sponsored enterprises |
|
|
22,409 |
|
|
|
— |
|
|
|
22,409 |
|
|
|
— |
|
Commercial paper |
|
|
89,950 |
|
|
|
— |
|
|
|
89,950 |
|
|
|
— |
|
Total marketable securities |
|
|
112,359 |
|
|
|
— |
|
|
|
112,359 |
|
|
|
— |
|
Total financial assets |
|
$ |
179,165 |
|
|
$ |
36,991 |
|
|
$ |
142,174 |
|
|
$ |
— |
|
When developing fair value estimates, the Company maximizes the use of observable inputs and minimizes the use of unobservable inputs. When available, the Company uses quoted market prices to measure the fair value. In determining the fair values at each date presented above, the Company relied on quoted prices for similar securities in active markets or using other inputs that are observable or can be corroborated by observable market data. During the six months ended June 30, 2024, there were no transfers between fair value measure levels.
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- DefinitionThe entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.
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v3.24.2.u1
Accrued Expenses and Other Current Liabilities
|
6 Months Ended |
Jun. 30, 2024 |
Payables and Accruals [Abstract] |
|
Accrued Expenses and Other Current Liabilities |
5. Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities consisted of the following:
|
|
|
|
|
|
|
|
|
|
|
As of June 30, 2024 |
|
|
As of December 31, 2023 |
|
|
|
(in thousands) |
|
Accrued research and development expense |
|
$ |
17,044 |
|
|
$ |
16,251 |
|
Accrued compensation and benefits |
|
|
4,376 |
|
|
|
6,981 |
|
Accrued professional services |
|
|
555 |
|
|
|
631 |
|
Other |
|
|
335 |
|
|
|
194 |
|
Total accrued expenses and other current liabilities |
|
$ |
22,310 |
|
|
$ |
24,057 |
|
|
X |
- DefinitionThe entire disclosure for accounts payable, accrued expenses, and other liabilities that are classified as current at the end of the reporting period.
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v3.24.2.u1
Collaborative Arrangements
|
6 Months Ended |
Jun. 30, 2024 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Collaborative Arrangements |
6. Collaborative Arrangements Debiopharm Clinical Study and Collaboration Agreement In January 2024, the Company entered into a clinical study and collaboration agreement with Debiopharm International S.A. (“Debiopharm”), a privately-owned, Swiss-based biopharmaceutical company, with the aim to explore the synergy between the Company’s compound, lunresertib, and Debiopharm’s compound, Debio 0123, a WEE1 inhibitor (the “Debio Collaboration Agreement”). The Company and Debiopharm are collaborating on the development of a combination therapy, with the Company sponsoring the global study, and will share all costs equally. The Company and Debiopharm are each supplying their respective drugs and retain all commercial rights to their respective compounds, including as monotherapy or as combination therapies. The activities associated with the Debio Collaboration Agreement are coordinated by a joint steering committee, which is comprised of an equal number of representatives from the Company and Debiopharm. Based on the terms of the Debio Collaboration Agreement, the Company concluded that the Debio Collaboration Agreement meets the requirements of a collaboration within the guidance of ASC 808, Collaborative Arrangements, as both parties are active participants in the combination trial and are exposed to significant risks and rewards depending on the success of the combination trial. Accordingly, the net costs associated with the co-development are expensed as incurred and recognized within research and development expenses in the consolidated statement of operations and comprehensive loss. During the three and six months ended June 30, 2024, the Company recognized $0.9 million and $1.4 million, respectively, in net research and development costs with regards to the Debiopharm portion of the 50/50 cost sharing terms in the Debio Collaboration Agreement, and recorded a receivable from Debiopharm of $0.7 million as of June 30, 2024 in other current receivables.
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v3.24.2.u1
Revenue recognition from Collaboration and License Agreements
|
6 Months Ended |
Jun. 30, 2024 |
Revenue Recognition [Abstract] |
|
Revenue recognition from Collaboration and License Agreements |
7. Revenue recognition from Collaboration and License Agreements The following table presents revenue from collaboration agreements:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Roche Collaboration and License Agreement |
|
$ |
1,073 |
|
|
$ |
4,825 |
|
|
$ |
50,888 |
|
|
$ |
10,137 |
|
Bristol-Myers Squibb Collaboration and License Agreement |
|
|
— |
|
|
|
14,951 |
|
|
|
2,589 |
|
|
|
15,317 |
|
Ono Collaboration Agreement |
|
|
— |
|
|
|
10,473 |
|
|
|
— |
|
|
|
10,473 |
|
Total revenue |
|
$ |
1,073 |
|
|
$ |
30,249 |
|
|
$ |
53,477 |
|
|
$ |
35,927 |
|
The Company’s revenue recognition accounting policy, as well as additional information on the Company’s collaboration and license agreements are disclosed in the audited consolidated financial statements for the year ended December 31, 2023 included in the Annual Report. Roche Collaboration and License Agreement In June 2022, the Company entered into a collaboration and license agreement (the “Roche Agreement”) with Hoffmann-La Roche Inc. and F. Hoffmann-La Roche Ltd (collectively, “Roche”) regarding the development and commercialization of the Company’s product candidate camonsertib (also known as RP-3500) and specified other Ataxia-Telangiectasia and Rad3-related protein kinase (“ATR”) inhibitors (the “Licensed Products”) which became effective July 13, 2022 (the “Effective Date”). Pursuant to the Roche Agreement, the Company granted Roche a worldwide, perpetual, exclusive, sublicensable license to develop, manufacture, and commercialize the Licensed Products, as well as a non-exclusive, sublicensable license to certain related companion diagnostics. The Company agreed to complete specified ongoing clinical trials in accordance with the development plan in the Roche Agreement, as well as ongoing investigator sponsored trials (together, the “Continuing Trials”) at the Company’s expense. Roche assumed all subsequent development of camonsertib with the potential to expand development into additional tumors and multiple combination studies. The Company retained the right to conduct specified clinical trials (the “Repare Trials”) of camonsertib in combination with the Company’s PKMYT1 compound, lunresertib (also known as RP-6306). The Roche Agreement provided the Company, at its sole discretion, with the ability to opt-in to a 50/50 U.S. co-development and profit share arrangement, including participation in U.S. co-promotion if U.S. regulatory approval was received. If the Company chose to exercise its co-development and profit share option, it would continue to be eligible to receive certain clinical, regulatory, commercial and sales milestone payments, in addition to full ex-U.S. royalties. On February 7, 2024, the Company received written notice from Roche of their election to terminate the Roche Agreement following a review of Roche’s pipeline and evolving external factors. The termination became effective May 7, 2024, at which time the Company regained global development and commercialization rights for camonsertib from Roche. In February 2024, the Company received a $40.0 million milestone payment from Roche that was earned upon dosing of the first patient with camonsertib in Roche’s Phase 2 TAPISTRY trial in January 2024. In March 2024, the Company received a further payment of $4.0 million for revisions to the clinical development plan under the Roche Agreement, of which $2.1 million was previously recorded as a receivable at December 31, 2023. The transaction price was updated for this additional consideration received, as well as other adjustments of $0.5 million pursuant to the termination of the agreement.
|
|
|
|
|
Deferred revenue pertaining to the Roche Agreement |
|
Completion of Continuing Trials |
|
|
|
(in thousands) |
|
Balance as of December 31, 2023 |
|
$ |
9,463 |
|
Increase in collaboration revenue |
|
|
41,425 |
|
Recognition as revenue, as the result of performance obligations satisfied |
|
|
(50,888 |
) |
Balance as of June 30, 2024 |
|
$ |
- |
|
The Company recognized $1.1 million and $4.8 million for the three months ended June 30, 2024 and 2023, respectively, and $50.9 million and $10.1 million for the six months ended June 30, 2024 and 2023, respectively, as revenue associated with the Roche Agreement in relation to (i) the recognition of revenue upon the $40.0 million milestone achievement in the first quarter of 2024, as well as (ii) the recognition of all remaining deferred revenue for research and development services performed towards the completion of the Continuing Trials during the period. Bristol-Myers Squibb Collaboration and License Agreement In May 2020, the Company entered into a collaboration and license agreement (the “BMS Agreement”) with Bristol-Myers Squibb Company (“Bristol-Myers Squibb”), pursuant to which the Company and Bristol-Myers Squibb have agreed to collaborate in the research and development of potential new product candidates for the treatment of cancer. The Company provided Bristol-Myers Squibb access to a selected number of its existing screening campaigns and novel campaigns. The Company was responsible for carrying out early-stage research activities directed to identifying potential targets for potential licensing by Bristol-Myers Squibb, in accordance with a mutually agreed upon research plan, and was solely responsible for such costs. The collaboration consisted of programs directed to both druggable targets and to targets commonly considered undruggable to traditional small molecule approaches. Upon Bristol-Myers Squibb’s election to exercise its option to obtain exclusive worldwide licenses for the subsequent development, manufacturing and commercialization of a program, Bristol-Myers Squibb will then be solely responsible for all such worldwide activities and costs. Although the collaboration term expired in November 2023, the BMS Agreement will not expire until, on a licensed product-by-licensed product and country-by-country basis, the expiration of the applicable royalty term and in its entirety upon expiration of the last royalty term. Either party may terminate earlier upon an uncured material breach of the agreement by the other party, or the insolvency of the other party. Additionally, Bristol-Myers Squibb may terminate the BMS Agreement for any or no reason on a program-by-program basis upon specified written notice. The Company is entitled to receive up to $301.0 million in total milestones on a program-by-program basis, consisting of $176.0 million in the aggregate for certain specified research, development and regulatory milestones and $125.0 million in the aggregate for certain specified commercial milestones. The Company is further entitled to a tiered percentage royalty on annual net sales ranging from high-single digits to low-double digits, subject to certain specified reductions.
|
|
|
|
|
Deferred revenue pertaining to the BMS Agreement |
|
Options to license undruggable targets |
|
|
|
(in thousands) |
|
Balance as of December 31, 2023 |
|
$ |
2,489 |
|
Increase in collaboration revenue |
|
|
100 |
|
Recognition as revenue, as the result of performance obligations satisfied |
|
|
(2,589 |
) |
Balance as of June 30, 2024 |
|
$ |
— |
|
In March 2024, Bristol-Myers Squibb exercised its one remaining option for an undruggable target. As a result, the Company recognized $2.6 million as revenue related to undruggable targets, including the option fee payment of $0.1 million. Ono Collaboration Agreement In January 2019, the Company entered into a research services, license and collaboration agreement, (the “Ono Agreement”), with Ono Pharmaceutical Company Ltd., or (“Ono”), pursuant to which the Company and Ono agreed to collaborate in the research of potential product candidates targeting Polθ and the development of the Company’s small molecule Polθ inhibitor program. In June 2023, the Company and Ono determined not to further extend the term of the Ono Agreement. As a result, no product candidate would be licensed to Ono pursuant to the terms of the Ono Agreement. The Company recognized approximately $10.5 million as revenue for the three and six months ended June 30, 2023 with regards to the performance obligation under the Ono Agreement. The Company did not recognize any revenue pursuant to the Ono Agreement during the three and six months ended June 30, 2024.
|
X |
- DefinitionThe entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts.
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v3.24.2.u1
Leases
|
6 Months Ended |
Jun. 30, 2024 |
Leases [Abstract] |
|
Leases |
8. Leases The Company has historically entered into lease arrangements for its facilities. As of June 30, 2024, the Company had four operating leases with required future minimum payments. The Company’s leases generally do not include termination or purchase options. Operating Leases The following tables contain a summary of the lease costs recognized under ASC 842 and other information pertaining to the Company’s operating leases:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Operating Leases - Lease Costs |
|
|
|
|
|
|
|
|
|
|
|
|
Operating lease costs |
|
$ |
593 |
|
|
$ |
593 |
|
|
$ |
1,187 |
|
|
$ |
1,186 |
|
Short-term lease costs |
|
|
15 |
|
|
|
32 |
|
|
|
34 |
|
|
|
46 |
|
Variable lease costs |
|
|
83 |
|
|
|
60 |
|
|
|
168 |
|
|
|
100 |
|
Total lease costs |
|
$ |
691 |
|
|
$ |
685 |
|
|
$ |
1,389 |
|
|
$ |
1,332 |
|
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands, except as specified otherwise) |
|
Other Operating Lease Information |
|
|
|
|
|
|
Operating cash flows used for operating leases |
|
$ |
1,223 |
|
|
$ |
1,202 |
|
Right-of-use assets obtained in exchange for new operating lease liability |
|
$ |
— |
|
|
$ |
149 |
|
Weighted-average remaining lease term (in years) |
|
|
1.00 |
|
|
|
1.95 |
|
Weighted-average discount rate |
|
|
4.3 |
% |
|
|
4.1 |
% |
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- DefinitionThe entire disclosure for operating leases of lessee. Includes, but is not limited to, description of operating lease and maturity analysis of operating lease liability.
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v3.24.2.u1
Share-Based Compensation
|
6 Months Ended |
Jun. 30, 2024 |
Share-Based Payment Arrangement [Abstract] |
|
Share-Based Compensation |
9. Share-Based Compensation 2020 Employee Share Purchase Plan In June 2020, the Company’s board of directors adopted, and the Company’s shareholders approved the 2020 Employee Share Purchase Plan (“ESPP”). The number of shares reserved and available for issuance under the ESPP will automatically increase each January 1, beginning on January 1, 2021 and each January 1 thereafter through January 31, 2030, by the lesser of (1) 1.0% of the total number of common shares outstanding on December 31 of the preceding calendar year, (2) 3,300,000 common shares, or (3) such smaller number of common shares as the Company’s board of directors may designate. The Company issued 60,618 common shares under the ESPP for the six months ended June 30, 2024, at a weighted-average price per share of $5.91, for aggregate proceeds of $0.4 million. As of June 30, 2024, the number of common shares that may be issued under the ESPP is 1,772,568. 2020 Equity Inventive Plan In June 2020, the Company’s board of directors adopted, and the Company’s shareholders approved the 2020 Equity Incentive Plan (the ”2020 Plan”). The 2020 Plan became effective on the effective date of the IPO, at which time the Company ceased making awards under the Option Plan. The 2020 Plan allows the Company’s compensation committee to make equity-based and cash-based incentive awards to the Company’s officers, employees, directors and consultants including but not limited to stock options and restricted share units. The aggregate number of common shares reserved and available for issuance under the 2020 Plan has automatically increased on January 1 of each year beginning on January 1, 2021 and will continue to increase on January 1 of each year through and including January 1, 2030, by 5% of the outstanding number of common shares on the immediately preceding December 31, or such lesser number of shares as determined by the Company’s board of directors. As of June 30, 2024, the number of common shares reserved for issuance under the 2020 Plan is 12,144,106. Inducement Plan In April 2024, the Company’s board of directors approved the adoption of the 2024 Inducement Plan (the “Inducement Plan”), to be used exclusively for grants of awards to individuals who were not previously employees or directors (or following a bona fide period of non-employment) as a material inducement to such individuals’ entry into employment with the Company, pursuant to Nasdaq Listing Rule 5635(c)(4). The terms and conditions of the Inducement Plan are substantially similar to those of the 2020 Plan. 350,000 common shares have been reserved for issuance under the Inducement Plan. Stock Options The following table summarizes the Company’s stock options activity:
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average exercise price |
|
Outstanding, January 1, 2024 |
|
|
10,097,771 |
|
|
$ |
13.77 |
|
Granted |
|
|
1,621,082 |
|
|
$ |
6.48 |
|
Exercised |
|
|
(8,612 |
) |
|
$ |
1.99 |
|
Cancelled or forfeited |
|
|
(421,652 |
) |
|
$ |
14.02 |
|
Outstanding, June 30, 2024 |
|
|
11,288,589 |
|
|
$ |
12.72 |
|
The fair value of stock options, and the assumptions used in the Black Scholes option-pricing model to determine the grant date fair value of stock options granted to employees and non-employees were as follows, presented on a weighted average basis:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair value of stock options |
|
$ |
2.67 |
|
|
$ |
7.08 |
|
|
$ |
4.72 |
|
|
$ |
8.33 |
|
Risk-free interest rate |
|
|
4.30 |
% |
|
|
3.75 |
% |
|
|
4.21 |
% |
|
|
3.68 |
% |
Expected terms (in years) |
|
|
5.33 |
|
|
|
5.81 |
|
|
|
5.97 |
|
|
|
6.00 |
|
Expected volatility |
|
|
83.57 |
% |
|
|
80.78 |
% |
|
|
83.08 |
% |
|
|
81.48 |
% |
Expected dividend yield |
|
|
0.00 |
% |
|
|
0.00 |
% |
|
|
0.00 |
% |
|
|
0.00 |
% |
Restricted Share Units The following table summarizes the Company’s restricted share unit activity:
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average grant date fair value |
|
Outstanding, January 1, 2024 |
|
|
603,685 |
|
|
$ |
12.42 |
|
Awarded |
|
|
527,273 |
|
|
$ |
6.95 |
|
Vested and released |
|
|
(200,262 |
) |
|
$ |
12.42 |
|
Forfeited |
|
|
(59,633 |
) |
|
$ |
11.34 |
|
Outstanding, June 30, 2024 |
|
|
871,063 |
|
|
$ |
9.18 |
|
The fair value of each restricted share unit is estimated on the date of grant based on the fair value of our common shares on that same date. Share-Based Compensation Share-based compensation expense for all awards was allocated as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Research and development |
|
$ |
3,694 |
|
|
$ |
3,329 |
|
|
$ |
7,113 |
|
|
$ |
6,548 |
|
General and administrative |
|
|
2,825 |
|
|
|
2,936 |
|
|
|
5,881 |
|
|
|
5,779 |
|
Total share-based compensation expense |
|
$ |
6,519 |
|
|
$ |
6,265 |
|
|
$ |
12,994 |
|
|
$ |
12,327 |
|
Share-based compensation expense by type of award was as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Stock options |
|
$ |
5,605 |
|
|
$ |
5,561 |
|
|
$ |
11,290 |
|
|
$ |
11,098 |
|
Restricted share units |
|
|
803 |
|
|
|
620 |
|
|
|
1,512 |
|
|
|
1,045 |
|
ESPP |
|
|
111 |
|
|
|
84 |
|
|
|
192 |
|
|
|
184 |
|
Total share-based compensation expense |
|
$ |
6,519 |
|
|
$ |
6,265 |
|
|
$ |
12,994 |
|
|
$ |
12,327 |
|
As of June 30, 2024, there was $31.3 million and $6.7 million of unrecognized share-based compensation expense to be recognized over a weighted average period of 1.4 years and 2.2 years related to unvested stock options and unvested restricted share units, respectively.
|
X |
- DefinitionThe entire disclosure for share-based payment arrangement.
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v3.24.2.u1
Net Loss per Share
|
6 Months Ended |
Jun. 30, 2024 |
Earnings Per Share [Abstract] |
|
Net Loss per Share |
11. Net Loss per Share The following table summarizes the computation of basic and diluted net loss per share attributable to common shareholders of the Company:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands, except share and per share amounts) |
|
Numerator: |
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
|
$ |
(34,774 |
) |
|
$ |
(11,946 |
) |
|
$ |
(21,612 |
) |
|
$ |
(46,887 |
) |
Denominator: |
|
|
|
|
|
|
|
|
|
|
|
|
Weighted-average common shares outstanding — basic and diluted |
|
|
42,445,462 |
|
|
|
42,089,530 |
|
|
|
42,339,732 |
|
|
|
42,065,237 |
|
Net loss per share - basic and diluted |
|
$ |
(0.82 |
) |
|
$ |
(0.28 |
) |
|
$ |
(0.51 |
) |
|
$ |
(1.11 |
) |
The Company excluded the following potential common shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common shareholders for the periods indicated because including them would have had an anti-dilutive effect:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Options to purchase common shares |
|
|
11,288,589 |
|
|
|
10,030,741 |
|
|
|
11,288,589 |
|
|
|
10,030,741 |
|
Restricted share units |
|
|
871,063 |
|
|
|
609,710 |
|
|
|
871,063 |
|
|
|
609,710 |
|
Estimated shares issuable under the ESPP |
|
|
78,964 |
|
|
|
48,316 |
|
|
|
78,964 |
|
|
|
48,316 |
|
|
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v3.24.2.u1
Summary of Significant Accounting Policies (Policies)
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Basis of Presentation |
Basis of Presentation The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America (“U.S. GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and as amended by Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). The unaudited condensed consolidated financial statements have been prepared on the same basis as the audited annual consolidated financial statements as of and for the year ended December 31, 2023, and, in the opinion of management, reflect all adjustments, consisting of normal recurring adjustments, necessary for the fair presentation of the Company’s consolidated financial position as of June 30, 2024, the consolidated results of its operations for the three and six months ended June 30, 2024 and 2023, its statements of shareholders’ equity for the three and six months ended June 30, 2024 and 2023 and its consolidated cash flows for the six months ended June 30, 2024 and 2023. These unaudited condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the accompanying notes for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K, filed with the Securities and Exchange Commission (the “SEC”) on February 28, 2024 (the “Annual Report”). The condensed consolidated balance sheet data as of December 31, 2023 presented for comparative purposes was derived from the Company’s audited consolidated financial statements but does not include all disclosures required by U.S. GAAP. The results for the three and six months ended June 30, 2024 are not necessarily indicative of the operating results to be expected for the full year or for any other subsequent interim period. The Company’s significant accounting policies are disclosed in the audited consolidated financial statements for the year ended December 31, 2023 included in the Annual Report. There have been no changes to the Company's significant accounting policies since the date of the audited consolidated financial statements for the year ended December 31, 2023 included in the Annual Report.
|
Principles of Consolidation |
Principles of Consolidation These unaudited condensed consolidated financial statements of the Company include the accounts of the Company and its wholly-owned subsidiary, Repare Therapeutics USA Inc. (“Repare USA”), which was incorporated under the laws of Delaware on June 1, 2017. The financial statements of Repare USA are prepared for the same reporting period as the parent company, using consistent accounting policies. All intra-group transactions, balances, income, and expenses are eliminated in full upon consolidation.
|
Smaller Reporting Company |
Smaller Reporting Company Repare qualifies as a “smaller reporting company” under the Exchange Act as of June 30, 2024 because the market value of its common shares held by non-affiliates was less than $200 million as of June 30, 2024. As a smaller reporting company, Repare may rely on exemptions from certain disclosure requirements that are available to smaller reporting companies. For so long as the Company remains a smaller reporting company, it is permitted and intends to rely on such exemptions from certain disclosure and other requirements that are applicable to other public companies that are not smaller reporting companies.
|
Use of Estimates |
Use of Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in consolidated financial statements and accompanying notes. Significant estimates and assumptions reflected in these unaudited condensed consolidated financial statements include, but are not limited to, estimates related to revenue recognition, accrued research and development expenses, share-based compensation and income taxes. The Company bases its estimates on historical experience and other market specific or other relevant assumptions that it believes to be reasonable under the circumstances. Actual results could differ from those estimates. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known.
|
Recently Issued Accounting Pronouncements Not Yet Adopted |
Recently Issued Accounting Pronouncements Not Yet Adopted In November 2023, the FASB amended the guidance in ASU 280, Segment Reporting, to require a public entity to disclose significant segment expenses and other segment items on an annual and interim basis and provide in interim periods all disclosures about a reportable segment’s profit or loss and assets that are currently required annually. Public entities with a single reportable segment are required to provide the new disclosures and all the disclosures currently required under ASC 280. The new guidance is effective for public entities in fiscal years beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. The Company is currently assessing the impact of this amendment on its consolidated financial statements. In December 2023, the FASB amended the guidance in ASU 740, Income Taxes, to provide disaggregated income tax disclosures on the rate reconciliation and income taxes paid. The new guidance is effective for public entities in fiscal years beginning after December 15, 2024. Early adoption is permitted. The Company is currently assessing the impact of this amendment on its consolidated financial statements.
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v3.24.2.u1
Cash and Cash Equivalents and Marketable Securities (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
Summary of Cash and Cash Equivalents and Marketable Securities |
Cash and cash equivalents and marketable securities were comprised of the following:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
|
|
(in thousands) |
|
As of June 30, 2024 |
|
|
|
|
|
|
|
|
|
|
|
|
Cash and cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Cash |
|
$ |
44,565 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
44,565 |
|
Money market funds |
|
|
35,255 |
|
|
|
— |
|
|
|
— |
|
|
|
35,255 |
|
Total cash and cash equivalents: |
|
$ |
79,820 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
79,820 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
Commercial paper |
|
$ |
109,240 |
|
|
$ |
5 |
|
|
$ |
(106 |
) |
|
$ |
109,139 |
|
Corporate debt securities |
|
|
19,198 |
|
|
|
— |
|
|
|
(34 |
) |
|
|
19,164 |
|
Total marketable securities |
|
$ |
128,438 |
|
|
$ |
5 |
|
|
$ |
(140 |
) |
|
$ |
128,303 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
As of December 31, 2023 |
|
|
|
|
|
|
|
|
|
|
|
|
Cash and cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Cash |
|
$ |
44,462 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
44,462 |
|
Money market funds |
|
|
36,991 |
|
|
|
— |
|
|
|
— |
|
|
|
36,991 |
|
Commercial paper |
|
|
29,811 |
|
|
|
4 |
|
|
|
— |
|
|
|
29,815 |
|
Total cash and cash equivalents: |
|
$ |
111,264 |
|
|
$ |
4 |
|
|
$ |
— |
|
|
$ |
111,268 |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury and government-sponsored enterprises |
|
$ |
22,434 |
|
|
$ |
— |
|
|
$ |
(25 |
) |
|
$ |
22,409 |
|
Commercial paper |
|
|
89,901 |
|
|
|
60 |
|
|
|
(11 |
) |
|
|
89,950 |
|
Total marketable securities |
|
$ |
112,335 |
|
|
$ |
60 |
|
|
$ |
(36 |
) |
|
$ |
112,359 |
|
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v3.24.2.u1
Fair Value Measurements (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Fair Value Disclosures [Abstract] |
|
Schedule of Financial Assets Measured at Fair Value on a Recurring Basis |
The following table presents information about the Company’s financial assets measured at fair value on a recurring basis and indicates the level of the fair value hierarchy utilized to determine such fair values:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Description |
|
Financial Assets |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
|
(in thousands) |
|
As of June 30, 2024 |
|
|
|
|
|
|
|
|
|
|
|
|
Assets |
|
|
|
|
|
|
|
|
|
|
|
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
35,255 |
|
|
$ |
35,255 |
|
|
$ |
— |
|
|
$ |
— |
|
Total cash equivalents |
|
|
35,255 |
|
|
|
35,255 |
|
|
|
— |
|
|
|
— |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
Commercial paper |
|
|
109,139 |
|
|
|
— |
|
|
|
109,139 |
|
|
|
— |
|
Corporate debt securities |
|
|
19,164 |
|
|
|
— |
|
|
|
19,164 |
|
|
|
— |
|
Total marketable securities |
|
|
128,303 |
|
|
|
— |
|
|
|
128,303 |
|
|
|
— |
|
Total financial assets |
|
$ |
163,558 |
|
|
$ |
35,255 |
|
|
$ |
128,303 |
|
|
$ |
— |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
As of December 31, 2023 |
|
|
|
|
|
|
|
|
|
|
|
|
Assets |
|
|
|
|
|
|
|
|
|
|
|
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
36,991 |
|
|
$ |
36,991 |
|
|
$ |
— |
|
|
$ |
— |
|
Commercial paper |
|
|
29,815 |
|
|
|
— |
|
|
|
29,815 |
|
|
|
— |
|
Total cash equivalents |
|
|
66,806 |
|
|
|
36,991 |
|
|
|
29,815 |
|
|
|
— |
|
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury and government-sponsored enterprises |
|
|
22,409 |
|
|
|
— |
|
|
|
22,409 |
|
|
|
— |
|
Commercial paper |
|
|
89,950 |
|
|
|
— |
|
|
|
89,950 |
|
|
|
— |
|
Total marketable securities |
|
|
112,359 |
|
|
|
— |
|
|
|
112,359 |
|
|
|
— |
|
Total financial assets |
|
$ |
179,165 |
|
|
$ |
36,991 |
|
|
$ |
142,174 |
|
|
$ |
— |
|
|
X |
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v3.24.2.u1
Accrued Expenses and Other Current Liabilities (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Payables and Accruals [Abstract] |
|
Schedule of Accrued Expenses and Other Current Liabilities |
Accrued expenses and other current liabilities consisted of the following:
|
|
|
|
|
|
|
|
|
|
|
As of June 30, 2024 |
|
|
As of December 31, 2023 |
|
|
|
(in thousands) |
|
Accrued research and development expense |
|
$ |
17,044 |
|
|
$ |
16,251 |
|
Accrued compensation and benefits |
|
|
4,376 |
|
|
|
6,981 |
|
Accrued professional services |
|
|
555 |
|
|
|
631 |
|
Other |
|
|
335 |
|
|
|
194 |
|
Total accrued expenses and other current liabilities |
|
$ |
22,310 |
|
|
$ |
24,057 |
|
|
X |
- DefinitionSchedule of accrued expenses and other current liabilities.
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v3.24.2.u1
Revenue recognition from Collaboration and License Agreements (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Disaggregation of Revenue [Line Items] |
|
Schedule of Revenue From Collaboration Agreements |
The following table presents revenue from collaboration agreements:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Roche Collaboration and License Agreement |
|
$ |
1,073 |
|
|
$ |
4,825 |
|
|
$ |
50,888 |
|
|
$ |
10,137 |
|
Bristol-Myers Squibb Collaboration and License Agreement |
|
|
— |
|
|
|
14,951 |
|
|
|
2,589 |
|
|
|
15,317 |
|
Ono Collaboration Agreement |
|
|
— |
|
|
|
10,473 |
|
|
|
— |
|
|
|
10,473 |
|
Total revenue |
|
$ |
1,073 |
|
|
$ |
30,249 |
|
|
$ |
53,477 |
|
|
$ |
35,927 |
|
|
Roche |
|
Disaggregation of Revenue [Line Items] |
|
Schedule of Deferred Revenue |
|
|
|
|
|
Deferred revenue pertaining to the Roche Agreement |
|
Completion of Continuing Trials |
|
|
|
(in thousands) |
|
Balance as of December 31, 2023 |
|
$ |
9,463 |
|
Increase in collaboration revenue |
|
|
41,425 |
|
Recognition as revenue, as the result of performance obligations satisfied |
|
|
(50,888 |
) |
Balance as of June 30, 2024 |
|
$ |
- |
|
|
Bristol-Myers Squibb Company |
|
Disaggregation of Revenue [Line Items] |
|
Schedule of Deferred Revenue |
|
|
|
|
|
Deferred revenue pertaining to the BMS Agreement |
|
Options to license undruggable targets |
|
|
|
(in thousands) |
|
Balance as of December 31, 2023 |
|
$ |
2,489 |
|
Increase in collaboration revenue |
|
|
100 |
|
Recognition as revenue, as the result of performance obligations satisfied |
|
|
(2,589 |
) |
Balance as of June 30, 2024 |
|
$ |
— |
|
|
X |
- DefinitionTabular disclosure of the type of arrangements and the corresponding amounts that comprise the current and noncurrent balance of deferred revenue as of the balance sheet date.
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v3.24.2.u1
Leases (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Leases [Abstract] |
|
Summary of Lease Costs |
The following tables contain a summary of the lease costs recognized under ASC 842 and other information pertaining to the Company’s operating leases:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Operating Leases - Lease Costs |
|
|
|
|
|
|
|
|
|
|
|
|
Operating lease costs |
|
$ |
593 |
|
|
$ |
593 |
|
|
$ |
1,187 |
|
|
$ |
1,186 |
|
Short-term lease costs |
|
|
15 |
|
|
|
32 |
|
|
|
34 |
|
|
|
46 |
|
Variable lease costs |
|
|
83 |
|
|
|
60 |
|
|
|
168 |
|
|
|
100 |
|
Total lease costs |
|
$ |
691 |
|
|
$ |
685 |
|
|
$ |
1,389 |
|
|
$ |
1,332 |
|
|
Summary of Other Operating Lease Information |
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands, except as specified otherwise) |
|
Other Operating Lease Information |
|
|
|
|
|
|
Operating cash flows used for operating leases |
|
$ |
1,223 |
|
|
$ |
1,202 |
|
Right-of-use assets obtained in exchange for new operating lease liability |
|
$ |
— |
|
|
$ |
149 |
|
Weighted-average remaining lease term (in years) |
|
|
1.00 |
|
|
|
1.95 |
|
Weighted-average discount rate |
|
|
4.3 |
% |
|
|
4.1 |
% |
|
X |
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v3.24.2.u1
Share-Based Compensation (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Share-Based Payment Arrangement [Abstract] |
|
Schedule of Share Option Activity |
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average exercise price |
|
Outstanding, January 1, 2024 |
|
|
10,097,771 |
|
|
$ |
13.77 |
|
Granted |
|
|
1,621,082 |
|
|
$ |
6.48 |
|
Exercised |
|
|
(8,612 |
) |
|
$ |
1.99 |
|
Cancelled or forfeited |
|
|
(421,652 |
) |
|
$ |
14.02 |
|
Outstanding, June 30, 2024 |
|
|
11,288,589 |
|
|
$ |
12.72 |
|
|
Schedule of Fair Value of Stock Options Determined on Grant Date Using Black Scholes Option-Pricing Model |
The fair value of stock options, and the assumptions used in the Black Scholes option-pricing model to determine the grant date fair value of stock options granted to employees and non-employees were as follows, presented on a weighted average basis:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair value of stock options |
|
$ |
2.67 |
|
|
$ |
7.08 |
|
|
$ |
4.72 |
|
|
$ |
8.33 |
|
Risk-free interest rate |
|
|
4.30 |
% |
|
|
3.75 |
% |
|
|
4.21 |
% |
|
|
3.68 |
% |
Expected terms (in years) |
|
|
5.33 |
|
|
|
5.81 |
|
|
|
5.97 |
|
|
|
6.00 |
|
Expected volatility |
|
|
83.57 |
% |
|
|
80.78 |
% |
|
|
83.08 |
% |
|
|
81.48 |
% |
Expected dividend yield |
|
|
0.00 |
% |
|
|
0.00 |
% |
|
|
0.00 |
% |
|
|
0.00 |
% |
|
Summary of Total Outstanding Restricted Stock Units |
The following table summarizes the Company’s restricted share unit activity:
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average grant date fair value |
|
Outstanding, January 1, 2024 |
|
|
603,685 |
|
|
$ |
12.42 |
|
Awarded |
|
|
527,273 |
|
|
$ |
6.95 |
|
Vested and released |
|
|
(200,262 |
) |
|
$ |
12.42 |
|
Forfeited |
|
|
(59,633 |
) |
|
$ |
11.34 |
|
Outstanding, June 30, 2024 |
|
|
871,063 |
|
|
$ |
9.18 |
|
|
Schedule of Share-based Compensation Expense |
Share-based compensation expense for all awards was allocated as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Research and development |
|
$ |
3,694 |
|
|
$ |
3,329 |
|
|
$ |
7,113 |
|
|
$ |
6,548 |
|
General and administrative |
|
|
2,825 |
|
|
|
2,936 |
|
|
|
5,881 |
|
|
|
5,779 |
|
Total share-based compensation expense |
|
$ |
6,519 |
|
|
$ |
6,265 |
|
|
$ |
12,994 |
|
|
$ |
12,327 |
|
Share-based compensation expense by type of award was as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands) |
|
Stock options |
|
$ |
5,605 |
|
|
$ |
5,561 |
|
|
$ |
11,290 |
|
|
$ |
11,098 |
|
Restricted share units |
|
|
803 |
|
|
|
620 |
|
|
|
1,512 |
|
|
|
1,045 |
|
ESPP |
|
|
111 |
|
|
|
84 |
|
|
|
192 |
|
|
|
184 |
|
Total share-based compensation expense |
|
$ |
6,519 |
|
|
$ |
6,265 |
|
|
$ |
12,994 |
|
|
$ |
12,327 |
|
|
X |
- DefinitionTabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.
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v3.24.2.u1
Net Loss per Share (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Earnings Per Share [Abstract] |
|
Summary of Computation of Basic and Diluted Net Loss Per Share Attributable To Common Shareholders |
The following table summarizes the computation of basic and diluted net loss per share attributable to common shareholders of the Company:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
|
|
(in thousands, except share and per share amounts) |
|
Numerator: |
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
|
$ |
(34,774 |
) |
|
$ |
(11,946 |
) |
|
$ |
(21,612 |
) |
|
$ |
(46,887 |
) |
Denominator: |
|
|
|
|
|
|
|
|
|
|
|
|
Weighted-average common shares outstanding — basic and diluted |
|
|
42,445,462 |
|
|
|
42,089,530 |
|
|
|
42,339,732 |
|
|
|
42,065,237 |
|
Net loss per share - basic and diluted |
|
$ |
(0.82 |
) |
|
$ |
(0.28 |
) |
|
$ |
(0.51 |
) |
|
$ |
(1.11 |
) |
|
Computation of Diluted Net Loss Per Share in Attributable to Common Shareholders Indicate to Anti Diluted Effect |
The Company excluded the following potential common shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common shareholders for the periods indicated because including them would have had an anti-dilutive effect:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Options to purchase common shares |
|
|
11,288,589 |
|
|
|
10,030,741 |
|
|
|
11,288,589 |
|
|
|
10,030,741 |
|
Restricted share units |
|
|
871,063 |
|
|
|
609,710 |
|
|
|
871,063 |
|
|
|
609,710 |
|
Estimated shares issuable under the ESPP |
|
|
78,964 |
|
|
|
48,316 |
|
|
|
78,964 |
|
|
|
48,316 |
|
|
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v3.24.2.u1
Cash and Cash Equivalents and Marketable Securities - Summary of Cash and Cash Equivalents and Marketable Securities (Details) - USD ($) $ in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Cash and cash equivalents |
|
|
Schedule Of Available For Sale Securities [Line Items] |
|
|
Amortized Cost |
$ 79,820
|
$ 111,264
|
Unrealized Gains |
0
|
4
|
Unrealized Losses |
0
|
0
|
Fair Value |
79,820
|
111,268
|
Money market funds | Cash and cash equivalents |
|
|
Schedule Of Available For Sale Securities [Line Items] |
|
|
Amortized Cost |
35,255
|
36,991
|
Unrealized Gains |
0
|
0
|
Unrealized Losses |
0
|
0
|
Fair Value |
35,255
|
36,991
|
Marketable securities |
|
|
Schedule Of Available For Sale Securities [Line Items] |
|
|
Amortized Cost |
128,438
|
112,335
|
Unrealized Gains |
5
|
60
|
Unrealized Losses |
(140)
|
(36)
|
Fair Value |
128,303
|
112,359
|
Commercial paper | Cash and cash equivalents |
|
|
Schedule Of Available For Sale Securities [Line Items] |
|
|
Amortized Cost |
|
29,811
|
Unrealized Gains |
|
4
|
Unrealized Losses |
|
0
|
Fair Value |
|
29,815
|
Commercial paper | Marketable securities |
|
|
Schedule Of Available For Sale Securities [Line Items] |
|
|
Amortized Cost |
109,240
|
89,901
|
Unrealized Gains |
5
|
60
|
Unrealized Losses |
(106)
|
(11)
|
Fair Value |
109,139
|
89,950
|
Corporate debt securities | Marketable securities |
|
|
Schedule Of Available For Sale Securities [Line Items] |
|
|
Amortized Cost |
19,198
|
|
Unrealized Gains |
0
|
|
Unrealized Losses |
(34)
|
|
Fair Value |
19,164
|
|
U.S. Treasury and government-sponsored enterprises | Marketable securities |
|
|
Schedule Of Available For Sale Securities [Line Items] |
|
|
Amortized Cost |
|
22,434
|
Unrealized Gains |
|
0
|
Unrealized Losses |
|
(25)
|
Fair Value |
|
22,409
|
Cash | Cash and cash equivalents |
|
|
Schedule Of Available For Sale Securities [Line Items] |
|
|
Amortized Cost |
44,565
|
44,462
|
Fair Value |
$ 44,565
|
$ 44,462
|
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Cash and Cash Equivalents and Marketable Securities - Additional Information (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
|
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Dec. 31, 2023 |
Investments, Debt and Equity Securities [Abstract] |
|
|
|
|
|
Interest receivable |
$ 400,000
|
|
$ 400,000
|
|
$ 400,000
|
Debt securities unrealized loss position |
103,500,000
|
|
103,500,000
|
|
$ 58,600,000
|
OCI, unrealized loss on available for sale marketable securities |
$ 21,000
|
$ 189,000
|
162,000
|
$ (4,000)
|
|
Allowance for credit losses or other impairment charges |
|
|
$ 0
|
$ 0
|
|
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Fair Value Measurements - Schedule of Financial Assets Measured at Fair Value on a Recurring Basis (Details) - Fair Value Measurements, Recurring - USD ($) $ in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Assets |
|
|
Cash equivalents |
$ 35,255
|
$ 66,806
|
Marketable securities |
128,303
|
112,359
|
Total financial assets |
163,558
|
179,165
|
Corporate debt securities |
|
|
Assets |
|
|
Marketable securities |
19,164
|
|
U.S. Treasury and government-sponsored enterprises |
|
|
Assets |
|
|
Marketable securities |
|
22,409
|
Level 1 |
|
|
Assets |
|
|
Cash equivalents |
35,255
|
36,991
|
Marketable securities |
0
|
0
|
Total financial assets |
35,255
|
36,991
|
Level 2 |
|
|
Assets |
|
|
Cash equivalents |
0
|
29,815
|
Marketable securities |
128,303
|
112,359
|
Total financial assets |
128,303
|
142,174
|
Level 2 | Corporate debt securities |
|
|
Assets |
|
|
Marketable securities |
19,164
|
|
Level 2 | U.S. Treasury and government-sponsored enterprises |
|
|
Assets |
|
|
Marketable securities |
|
22,409
|
Money market funds |
|
|
Assets |
|
|
Total financial assets |
35,255
|
36,991
|
Money market funds | Level 1 |
|
|
Assets |
|
|
Total financial assets |
35,255
|
36,991
|
Commercial paper |
|
|
Assets |
|
|
Cash equivalents |
|
29,815
|
Marketable securities |
109,139
|
89,950
|
Commercial paper | Level 2 |
|
|
Assets |
|
|
Cash equivalents |
|
29,815
|
Marketable securities |
$ 109,139
|
$ 89,950
|
X |
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Revenue recognition from Collaboration and License Agreements - Schedule of Revenue From Collaboration Agreements (Details) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Disaggregation of Revenue [Line Items] |
|
|
|
|
Collaboration agreements |
$ 1,073
|
$ 30,249
|
$ 53,477
|
$ 35,927
|
Roche |
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
Collaboration agreements |
1,073
|
4,825
|
50,888
|
10,137
|
Bristol-Myers Squibb Company |
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
Collaboration agreements |
0
|
14,951
|
2,589
|
15,317
|
Ono Collaboration Agreement |
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
Collaboration agreements |
$ 0
|
$ 10,473
|
$ 0
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$ 10,473
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v3.24.2.u1
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1 Months Ended |
3 Months Ended |
6 Months Ended |
|
|
Mar. 31, 2024 |
May 31, 2020 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Feb. 29, 2024 |
Dec. 31, 2023 |
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
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|
|
$ 1,073
|
$ 30,249
|
$ 53,477
|
$ 35,927
|
|
|
Roche |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
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Revenue from collaboration agreements |
|
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1,073
|
4,825
|
50,888
|
10,137
|
|
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Roche | Completion of Continuing Trials [Member] |
|
|
|
|
|
|
|
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Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
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Deferred revenue |
|
|
0
|
|
0
|
|
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$ 9,463
|
Roche | Collaboration and License Agreement |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
|
Collaboration payable |
$ 500
|
|
|
|
|
|
|
|
Milestones payments received |
|
|
|
|
|
|
$ 40,000
|
|
Deferred revenue recognized |
|
|
1,100
|
4,800
|
50,900
|
10,100
|
|
|
Roche | Collaboration and License Agreement | Third Additional Clinical Development Plan |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
|
Collaboration revenue received |
4,000
|
|
|
|
|
|
|
|
Collaboration revenue receivable earned |
|
|
|
|
|
|
|
$ 2,100
|
Bristol-Myers Squibb Company |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
|
Revenue from collaboration agreements |
|
|
0
|
14,951
|
2,589
|
15,317
|
|
|
Bristol-Myers Squibb Company | Collaboration and License Agreement |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
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Collaboration term expiration date |
|
Nov. 30, 2023
|
|
|
|
|
|
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Bristol-Myers Squibb Company | Collaboration and License Agreement | Undruggable targets |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
|
Deferred revenue recognized |
2,600
|
|
|
|
|
|
|
|
Option fee payment |
$ 100
|
|
|
|
|
|
|
|
Bristol-Myers Squibb Company | Collaboration and License Agreement | Maximum |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
|
Milestone payments entitled to be received |
|
$ 301,000
|
|
|
|
|
|
|
Bristol-Myers Squibb Company | Collaboration and License Agreement | Maximum | Research, Development and Regulatory Milestones |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
|
Milestone payments entitled to be received |
|
176,000
|
|
|
|
|
|
|
Bristol-Myers Squibb Company | Collaboration and License Agreement | Maximum | Commercial Milestones |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
|
Milestone payments entitled to be received |
|
$ 125,000
|
|
|
|
|
|
|
Ono Collaboration Agreement |
|
|
|
|
|
|
|
|
Disaggregation of Revenue [Line Items] |
|
|
|
|
|
|
|
|
Revenue from collaboration agreements |
|
|
$ 0
|
$ 10,473
|
$ 0
|
$ 10,473
|
|
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v3.24.2.u1
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Jun. 30, 2024
USD ($)
|
Roche | Completion of continuing trials |
|
Disaggregation of Revenue [Line Items] |
|
Balance, Beginning |
$ 9,463
|
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41,425
|
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|
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100
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v3.24.2.u1
Share-Based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands |
|
3 Months Ended |
6 Months Ended |
|
|
Jun. 30, 2020 |
Jun. 30, 2024 |
Mar. 31, 2024 |
Jun. 30, 2023 |
Mar. 31, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Apr. 30, 2024 |
Dec. 31, 2023 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
|
|
|
Common stock shares issued |
|
42,445,533
|
|
|
|
42,445,533
|
|
|
42,176,041
|
Weighted average exercise price of stock options granted |
|
|
|
|
|
$ 6.48
|
|
|
|
Number of options exercised |
|
|
|
|
|
8,612
|
|
|
|
Stock options granted to employees |
|
|
|
|
|
1,621,082
|
|
|
|
Options, weighted-average exercise price |
|
|
|
|
|
$ 1.99
|
|
|
|
Aggregate proceeds from exercise of options |
|
|
|
|
|
$ 17
|
$ 44
|
|
|
Restricted Stock Units (RSUs) |
|
|
|
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
|
|
|
Unrecognized share-based compensation expense related to unvested restricted share units |
|
$ 6,700
|
|
|
|
$ 6,700
|
|
|
|
Unrecognized share-based compensation expense related to unvested stock options, weighted average period |
|
|
|
|
|
2 years 2 months 12 days
|
|
|
|
Employee Stock Option |
|
|
|
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
|
|
|
Unrecognized share-based compensation expense related to unvested stock options |
|
$ 31,300
|
|
|
|
$ 31,300
|
|
|
|
Unrecognized share-based compensation expense related to unvested stock options, weighted average period |
|
|
|
|
|
1 year 4 months 24 days
|
|
|
|
Inducement Plan |
|
|
|
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
|
|
|
Shares of common stock reserved for future issuance |
|
|
|
|
|
|
|
350,000
|
|
Common Shares |
|
|
|
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
|
|
|
Number of options exercised |
|
127
|
8,485
|
14,050
|
2,000
|
|
|
|
|
2020 Employee Share Purchase Plan |
|
|
|
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
|
|
|
Shares of common stock reserved for future issuance |
|
1,772,568
|
|
|
|
1,772,568
|
|
|
|
Annual increases in number of shares available for issuance as percentage of outstanding shares common stock on final day of preceding calendar year |
1.00%
|
|
|
|
|
|
|
|
|
Annual increases in number of shares available for issuance maximum number of common stock issued |
3,300,000
|
|
|
|
|
|
|
|
|
Common stock shares issued |
|
60,618
|
|
|
|
60,618
|
|
|
|
Shares issued, price per share |
|
$ 5.91
|
|
|
|
$ 5.91
|
|
|
|
Cash received from purchases under ESPP |
|
|
|
|
|
$ 400
|
|
|
|
2020 Equity Incentive Plan |
|
|
|
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
|
|
|
Shares of common stock reserved for future issuance |
|
12,144,106
|
|
|
|
12,144,106
|
|
|
|
Annual increases in number of shares available for issuance as percentage of outstanding shares common stock on final day of preceding calendar year |
5.00%
|
|
|
|
|
|
|
|
|
X |
- DefinitionAnnual increase in number of shares available for issuance as percentage on outstanding shares of common stock on final day of preceding calendar year.
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v3.24.2.u1
Share-Based Compensation - Schedule of Share Option Activity (Details)
|
6 Months Ended |
Jun. 30, 2024
$ / shares
shares
|
Share-Based Payment Arrangement [Abstract] |
|
Number of shares, Outstanding at beginning of period | shares |
10,097,771
|
Number of shares, Granted | shares |
1,621,082
|
Number of shares, Exercised | shares |
(8,612)
|
Number of shares, Cancelled or forfeited | shares |
(421,652)
|
Number of shares, Outstanding at end of period | shares |
11,288,589
|
Weighted average exercise price, Outstanding at beginning of period | $ / shares |
$ 13.77
|
Weighted average exercise price of stock options granted | $ / shares |
6.48
|
Weighted average exercise price, Exercised | $ / shares |
1.99
|
Weighted average exercise price, Cancelled or forfeited | $ / shares |
14.02
|
Weighted average exercise price, Outstanding at end of period | $ / shares |
$ 12.72
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Share-Based Compensation - Summary of Total Outstanding Restricted Stock Units (Details) - Restricted Stock Units (RSUs)
|
6 Months Ended |
Jun. 30, 2024
$ / shares
shares
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
Restricted stock units, Beginning balance | shares |
603,685
|
Restricted stock units, Awarded | shares |
527,273
|
Restricted stock units, Vested and released | shares |
(200,262)
|
Restricted stock units, Forfeited | shares |
(59,633)
|
Restricted stock units, Ending balance | shares |
871,063
|
Weighted average grant date fair value, Beginning balance | $ / shares |
$ 12.42
|
Weighted average grant date fair value, Awarded | $ / shares |
6.95
|
Weighted average grant date fair value, Vested and released | $ / shares |
12.42
|
Weighted Average Grant Date Fair Value Forfeited | $ / shares |
11.34
|
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$ 9.18
|
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Share-Based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] |
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|
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|
|
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|
|
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|
|
|
|
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|
|
|
|
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|
2,936
|
5,881
|
5,779
|
Employee Stock Option |
|
|
|
|
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|
|
|
|
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|
5,561
|
11,290
|
11,098
|
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|
|
|
|
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|
|
|
|
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|
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|
1,512
|
1,045
|
2020 Employee Share Purchase Plan |
|
|
|
|
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] |
|
|
|
|
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|
$ 84
|
$ 192
|
$ 184
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Net Loss per Share - Summary of Basic and Diluted Net Loss per Share Attributable to Common Stockholders (Details) - USD ($) $ / shares in Units, $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Numerator: |
|
|
|
|
Net loss |
$ (34,774)
|
$ (11,946)
|
$ (21,612)
|
$ (46,887)
|
Denominator: |
|
|
|
|
Weighted-average common shares outstanding-basic |
42,445,462
|
42,089,530
|
42,339,732
|
42,065,237
|
Weighted-average common shares outstanding-diluted |
42,445,462
|
42,089,530
|
42,339,732
|
42,065,237
|
Net loss per share basic |
$ (0.82)
|
$ (0.28)
|
$ (0.51)
|
$ (1.11)
|
Net loss per share diluted |
$ (0.82)
|
$ (0.28)
|
$ (0.51)
|
$ (1.11)
|
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v3.24.2.u1
Net Loss per Share - Computation of Diluted Net Loss Per Share in Attributable to Common Shareholders Indicate to Anti Diluted Effect (Details) - shares
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Options to Purchase Common Shares |
|
|
|
|
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
|
|
Antidilutive securities excluded from computation of earnings per share amount |
11,288,589
|
10,030,741
|
11,288,589
|
10,030,741
|
Restricted Stock Units (RSUs) |
|
|
|
|
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
|
|
Antidilutive securities excluded from computation of earnings per share amount |
871,063
|
609,710
|
871,063
|
609,710
|
Estimated Shares Issuable Under the ESPP |
|
|
|
|
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
|
|
Antidilutive securities excluded from computation of earnings per share amount |
78,964
|
48,316
|
78,964
|
48,316
|
X |
- DefinitionSecurities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.
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