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Table of Contents
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 10-Q
☒
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended June 30, 2023
OR
☐
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from
to
Commission File Number: 001-36304
Phio Pharmaceuticals Corp.
(Exact name of registrant as specified in its
charter)
Delaware |
45-3215903 |
(State or other jurisdiction of incorporation or organization) |
(I.R.S. Employer Identification No.) |
257 Simarano Drive, Suite 101, Marlborough,
MA 01752
(Address of principal executive office) (Zip
code)
Registrant’s telephone number, including
area code: (508) 767-3861
Securities registered pursuant to Section 12(b)
of the Act:
Title of each class |
Trading Symbol(s) |
Name of each exchange on which registered |
Common Stock, par value, $0.0001 per share |
PHIO |
The Nasdaq Capital Market |
Indicate by check mark whether the registrant
(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months
(or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements
for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant
has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405
of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes
☒ No ☐
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.
See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,”
and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer |
|
☐ |
|
Accelerated filer |
|
☐ |
Non-accelerated filer |
|
☒ |
|
Smaller reporting company |
|
☒ |
|
|
|
|
Emerging growth company |
|
☐ |
If an emerging growth company, indicate by check
mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by checkmark whether the registrant is
a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐
No ☒
As of August 4, 2023, Phio Pharmaceuticals Corp. had 2,221,856
shares of common stock, $0.0001 par value, outstanding.
PHIO PHARMACEUTICALS CORP.
FORM 10-Q — QUARTER ENDED JUNE 30, 2023
INDEX
PART I — FINANCIAL INFORMATION
ITEM 1. |
FINANCIAL STATEMENTS |
PHIO PHARMACEUTICALS CORP.
CONDENSED CONSOLIDATED BALANCE SHEETS
(Amounts in thousands, except share and per
share data)
(Unaudited)
| |
| | |
| |
| |
June 30, 2023 | | |
December 31, 2022 | |
ASSETS | |
| | | |
| | |
Current assets: | |
| | | |
| | |
Cash | |
$ | 11,307 | | |
$ | 11,781 | |
Restricted cash | |
| 50 | | |
| 50 | |
Prepaid expenses and other current assets | |
| 678 | | |
| 615 | |
Total current assets | |
| 12,035 | | |
| 12,446 | |
Right of use asset | |
| 98 | | |
| 161 | |
Property and equipment, net | |
| 157 | | |
| 183 | |
Other assets | |
| 6 | | |
| 24 | |
Total assets | |
$ | 12,296 | | |
$ | 12,814 | |
LIABILITIES, PREFERRED STOCK AND STOCKHOLDERS’ EQUITY | |
| | | |
| | |
Current liabilities: | |
| | | |
| | |
Accounts payable | |
$ | 641 | | |
$ | 779 | |
Accrued expenses | |
| 1,647 | | |
| 1,025 | |
Lease liability | |
| 104 | | |
| 135 | |
Total current liabilities | |
| 2,392 | | |
| 1,939 | |
Lease liability, net of current portion | |
| – | | |
| 35 | |
Total liabilities | |
| 2,392 | | |
| 1,974 | |
Commitments and contingencies (Note 2) | |
| – | | |
| – | |
Series D Preferred Stock, $0.0001 par value; 0 and 1 shares authorized, issued and outstanding at June 30, 2023 and December 31, 2022, respectively | |
| – | | |
| 2 | |
Stockholders’ equity: | |
| | | |
| | |
Common stock, $0.0001 par value, 100,000,000 shares authorized; 1,985,211 and 1,139,024 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively | |
| – | | |
| – | |
Additional paid-in capital | |
| 144,435 | | |
| 139,218 | |
Accumulated deficit | |
| (134,531 | ) | |
| (128,380 | ) |
Total stockholders’ equity | |
| 9,904 | | |
| 10,838 | |
Total liabilities, preferred stock and stockholders’ equity | |
$ | 12,296 | | |
$ | 12,814 | |
The accompanying notes are an integral part of
these condensed consolidated financial statements.
PHIO PHARMACEUTICALS CORP.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(Amounts in thousands, except share and per
share data)
(Unaudited)
| |
| | |
| | |
| | |
| |
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Operating expenses: | |
| | | |
| | | |
| | | |
| | |
Research and development | |
$ | 1,383 | | |
$ | 1,304 | | |
$ | 3,517 | | |
$ | 2,890 | |
General and administrative | |
| 1,164 | | |
| 1,217 | | |
| 2,632 | | |
| 2,271 | |
Total operating expenses | |
| 2,547 | | |
| 2,521 | | |
| 6,149 | | |
| 5,161 | |
Operating loss | |
| (2,547 | ) | |
| (2,521 | ) | |
| (6,149 | ) | |
| (5,161 | ) |
Total other expense, net | |
| (2 | ) | |
| (10 | ) | |
| (2 | ) | |
| (12 | ) |
Net loss | |
$ | (2,549 | ) | |
$ | (2,531 | ) | |
$ | (6,151 | ) | |
$ | (5,173 | ) |
Net loss per common share: | |
| | | |
| | | |
| | | |
| | |
Basic and diluted | |
$ | (1.47 | ) | |
$ | (2.22 | ) | |
$ | (4.28 | ) | |
$ | (4.56 | ) |
Weighted average number of common shares outstanding | |
| | | |
| | | |
| | | |
| | |
Basic and diluted | |
| 1,728,490 | | |
| 1,138,227 | | |
| 1,436,971 | | |
| 1,134,307 | |
The accompanying notes are an integral part of
these condensed consolidated financial statements.
PHIO PHARMACEUTICALS CORP.
CONDENSED CONSOLIDATED STATEMENTS OF
PREFERRED STOCK AND STOCKHOLDERS’ EQUITY
(Amounts in thousands, except share data)
(Unaudited)
| |
| | |
| | |
| | |
| | |
| | |
| | |
| |
| |
Series
D Preferred Stock | | |
Common
Stock | | |
Additional
Paid-in | | |
Accumulated | | |
| |
For the Three and Six Months Ended June
30, 2023 | |
Shares | | |
Amount | | |
Shares | | |
Amount | | |
Capital | | |
Deficit | | |
Total | |
Balance at December 31, 2022 | |
| 1 | | |
$ | 2 | | |
| 1,139,024 | | |
$ | – | | |
$ | 139,218 | | |
$ | (128,380 | ) | |
$ | 10,838 | |
Cash-in-lieu of fractional shares for reverse stock split | |
| – | | |
| – | | |
| (1,706 | ) | |
| – | | |
| (11 | ) | |
| – | | |
| (11 | ) |
Redemption of preferred stock | |
| (1 | ) | |
| (2 | ) | |
| – | | |
| – | | |
| – | | |
| – | | |
| – | |
Issuance of common stock upon vesting of restricted stock units | |
| – | | |
| – | | |
| 18,080 | | |
| – | | |
| – | | |
| – | | |
| – | |
Shares withheld for payroll taxes | |
| – | | |
| – | | |
| (4,816 | ) | |
| – | | |
| (25 | ) | |
| – | | |
| (25 | ) |
Stock-based compensation expense | |
| – | | |
| – | | |
| – | | |
| – | | |
| 111 | | |
| – | | |
| 111 | |
Net loss | |
| – | | |
| – | | |
| – | | |
| – | | |
| – | | |
| (3,602 | ) | |
| (3,602 | ) |
Balance at March 31, 2023 | |
| – | | |
$ | – | | |
| 1,150,582 | | |
$ | – | | |
$ | 139,293 | | |
$ | (131,982 | ) | |
$ | 7,311 | |
Issuance of common stock and warrants, net of offering costs | |
| – | | |
| – | | |
| 659,629 | | |
| – | | |
| 5,048 | | |
| – | | |
| 5,048 | |
Issuance of common stock upon exercise of warrants | |
| – | | |
| – | | |
| 175,000 | | |
| – | | |
| – | | |
| – | | |
| – | |
Stock-based compensation expense | |
| – | | |
| – | | |
| – | | |
| – | | |
| 94 | | |
| – | | |
| 94 | |
Net loss | |
| – | | |
| – | | |
| – | | |
| – | | |
| – | | |
| (2,549 | ) | |
| (2,549 | ) |
Balance at June 30, 2023 | |
| – | | |
$ | – | | |
| 1,985,211 | | |
$ | – | | |
$ | 144,435 | | |
$ | (134,531 | ) | |
$ | 9,904 | |
| |
| | |
| | |
| | |
| | |
| | |
| | |
| |
For the Three and Six Months Ended June
30, 2022 | |
Series
D Preferred Stock | | |
Common
Stock | | |
Additional
Paid-in | | |
Accumulated | | |
| |
| |
Shares | | |
Amount | | |
Shares | | |
Amount | | |
Capital | | |
Deficit | | |
Total | |
Balance at December 31, 2021 | |
| – | | |
$ | – | | |
| 1,127,917 | | |
$ | – | | |
$ | 138,832 | | |
$ | (116,900 | ) | |
$ | 21,932 | |
Issuance of common stock upon vesting of restricted stock units | |
| – | | |
| – | | |
| 12,943 | | |
| – | | |
| – | | |
| – | | |
| – | |
Shares withheld for payroll taxes | |
| – | | |
| – | | |
| (2,633 | ) | |
| – | | |
| (25 | ) | |
| – | | |
| (25 | ) |
Stock-based compensation expense | |
| – | | |
| – | | |
| – | | |
| – | | |
| 186 | | |
| – | | |
| 186 | |
Net loss | |
| – | | |
| – | | |
| – | | |
| – | | |
| – | | |
| (2,642 | ) | |
| (2,642 | ) |
Balance at March 31, 2022 | |
| – | | |
$ | – | | |
| 1,138,227 | | |
$ | – | | |
$ | 138,993 | | |
$ | (119,542 | ) | |
$ | 19,451 | |
Stock-based compensation expense | |
| – | | |
| – | | |
| – | | |
| – | | |
| 83 | | |
| – | | |
| 83 | |
Net loss | |
| – | | |
| – | | |
| – | | |
| – | | |
| – | | |
| (2,531 | ) | |
| (2,531 | ) |
Balance at June 30, 2022 | |
| – | | |
$ | – | | |
| 1,138,227 | | |
$ | – | | |
$ | 139,076 | | |
$ | (122,073 | ) | |
$ | 17,003 | |
The accompanying notes are an integral part of
these condensed consolidated financial statements.
PHIO PHARMACEUTICALS CORP.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(Amounts in thousands)
(Unaudited)
| |
| | |
| |
| |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | |
Cash flows from operating activities: | |
| | | |
| | |
Net loss | |
$ | (6,151 | ) | |
$ | (5,173 | ) |
Adjustments to reconcile net loss to net cash used in operating activities: | |
| | | |
| | |
Depreciation and amortization | |
| 31 | | |
| 41 | |
Amortization of right of use asset | |
| 63 | | |
| 60 | |
Stock-based compensation | |
| 205 | | |
| 269 | |
Changes in operating assets and liabilities: | |
| | | |
| | |
Prepaid expenses and other assets | |
| (45 | ) | |
| (998 | ) |
Accounts payable | |
| (138 | ) | |
| 865 | |
Accrued expenses | |
| 622 | | |
| (901 | ) |
Lease liability | |
| (66 | ) | |
| (61 | ) |
Net cash used in operating activities | |
| (5,479 | ) | |
| (5,898 | ) |
Cash flows from investing activities: | |
| | | |
| | |
Cash paid for purchase of property and equipment | |
| (5 | ) | |
| (114 | ) |
Net cash used in investing activities | |
| (5 | ) | |
| (114 | ) |
Cash flows from financing activities: | |
| | | |
| | |
Net proceeds from the issuance of common stock and warrants | |
| 5,048 | | |
| – | |
Cash in lieu of fractional shares for reverse stock split | |
| (11 | ) | |
| – | |
Redemption of Series D preferred stock | |
| (2 | ) | |
| – | |
Payment of taxes on net share settlements of restricted stock units | |
| (25 | ) | |
| (25 | ) |
Net cash provided by (used in) financing activities | |
| 5,010 | | |
| (25 | ) |
Net decrease in cash and restricted cash | |
| (474 | ) | |
| (6,037 | ) |
Cash and restricted cash at the beginning of period | |
| 11,831 | | |
| 24,107 | |
Cash and restricted cash at the end of period | |
$ | 11,357 | | |
$ | 18,070 | |
The following table provides a reconciliation of cash and restricted
cash reported within the consolidated balance sheets to the totals above:
| |
| | |
| |
| |
June 30, | |
| |
2023 | | |
2022 | |
Cash | |
$ | 11,307 | | |
$ | 18,020 | |
Restricted cash | |
| 50 | | |
| 50 | |
Cash and restricted cash | |
$ | 11,357 | | |
$ | 18,070 | |
The accompanying notes are an integral part of
these condensed consolidated financial statements.
PHIO PHARMACEUTICALS CORP.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(Unaudited)
1. Organization and Significant Accounting Policies
Nature of Operations
Phio Pharmaceuticals Corp. (“Phio”
or the “Company”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology
platform is designed to make immune cells more effective in killing tumor cells. Phio is developing therapeutics that are designed to
leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized
formulations or drug delivery systems.
Effective January 26, 2023, the Company completed
a 1-for-12 reverse stock split of the Company’s outstanding common stock, including reclassifying an amount equal to the reduction
in par value to additional paid-in capital. The reverse stock split did not reduce the number of authorized shares of the Company’s
common or preferred stock. All share and per share amounts have been adjusted to give effect to the reverse stock split.
Principles of Consolidation
The condensed consolidated
financial statements include the accounts of Phio and its wholly-owned subsidiary, MirImmune, LLC. All material intercompany accounts
have been eliminated in consolidation.
Basis of Presentation
The accompanying condensed consolidated financial statements are unaudited
and have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”). Certain
information and footnote disclosures that are included in the Company’s annual consolidated financial statements, but that are not
required for interim reporting purposes, have been condensed or omitted. Additionally, the Company made adjustments to the outstanding
stock option and unvested restricted stock unit balances, and related per share amounts, at December 31, 2022 to reflect final revisions
to these outstanding equity awards as a result of the Company’s reverse stock split. The adjustment had no effect on the Company’s
condensed consolidated financial statements. These statements should be read in conjunction with the audited consolidated financial statements
and notes thereto included in the Company’s most recent Annual Report on Form 10-K for the year ended December 31, 2022, as filed
with the Securities and Exchange Commission (the “SEC”) on March 22, 2023 (the “2022 Form 10-K”).
In the opinion of management, all adjustments (including normal recurring accruals) considered necessary for a fair presentation of the
condensed consolidated financial statements have been included. Interim results are not necessarily indicative of results for a full year.
Use of Estimates
The preparation of financial
statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and
liabilities and disclosure of contingent assets and liabilities as of the date of the financial statements and the reported amounts of
revenues and expenses during the reporting period. The areas subject to significant estimates and judgement include, among others, those
related to the fair value of equity awards, accruals for research and development expenses, useful lives of property and equipment, income
taxes, and the valuation allowance on the Company’s deferred tax assets. On an ongoing basis the Company evaluates its estimates
and bases its estimates on historical experience and other relevant assumptions that the Company believes are reasonable under the circumstances.
Actual results could differ materially from these estimates.
Liquidity
The Company has reported recurring
losses from operations since inception and expects to continue to have negative cash flows from operations for the foreseeable future.
Historically, the Company’s primary source of funding has been from sales of its securities. The Company’s ability to continue
to fund its operations is dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity,
or strategic opportunities, in order to maintain its operations. This is dependent on a number of factors, including the market demand
or liquidity of the Company’s common stock. There is no guarantee that debt, additional equity or other funding will be available
to the Company on acceptable terms, or at all. If the Company fails to obtain additional funding when needed, the Company would be forced
to scale back or terminate its operations or seek to merge with or to be acquired by another company.
The Company has limited cash
resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise
substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources
may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial
statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through
an equity offering, debt offering and/or strategic opportunity to fund its operations. There can be no assurance that the Company will
be successful in accomplishing these plans in order to continue as a going concern. These financial statements do not include any adjustments
to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the
Company be unable to continue as a going concern.
Summary of Significant Accounting Policies
There have been no material
changes to the significant accounting policies disclosed in the Company’s 2022 Form 10-K.
Recent Accounting Pronouncements
There have been no recent
accounting pronouncements that have significantly impacted this Quarterly Report on Form 10-Q, beyond those disclosed in the Company’s
2022 Form 10-K.
2. Collaboration Agreement
AgonOx, Inc. (“AgonOx”)
In March 2021, the
Company entered into a clinical co-development collaboration agreement (the “Clinical Co-Development Agreement”)
with AgonOx, a private company developing a pipeline of novel immunotherapy drugs targeting key regulators of the immune response to
cancer. Under the Clinical Co-Development Agreement, Phio and AgonOx are working to develop a T cell-based therapy using the
Company’s lead product candidate, PH-762, and AgonOx’s “double positive” tumor infiltrating lymphocytes
(“DP TIL”) technology. Per the terms of the Clinical Co-Development Agreement, the Company committed to provide
financial support for development costs of up to $4,000,000
to AgonOx for expenses incurred to conduct a Phase 1 clinical trial of PH-762 treated DP TIL in patients with advanced melanoma and
other advanced solid tumors.
The Company will recognize
its share of costs arising from research and development activities performed by AgonOx in the Company’s financial statements in
the period AgonOx incurs such expense. Phio will be entitled to certain future development milestones and low single-digit sales-based
royalty payments from AgonOx’s licensing of its DP TIL technology.
The Company recognized
approximately $181,000
and $300,000
of expense in connection with these efforts during the three and six months ended June 30, 2023, respectively. No
expense under the Clinical Co-Development Agreement was recognized during the three and six months ended June 30, 2022.
There is approximately $3,570,000
of remaining costs not yet incurred under the Clinical Co-Development Agreement as of June 30, 2023.
3. Fair Value of Financial Instruments
The Company follows the provisions
of the Financial Accounting Standards Board (the “FASB”) Accounting Standards Codification (“ASC”)
Topic 820, “Fair Value Measurement,” for the Company’s financial assets and liabilities that are re-measured
and reported at fair value each reporting period and are re-measured and reported at fair value at least annually using a fair value hierarchy
that is broken down into three levels. Level inputs are defined as follows:
Level 1 – quoted prices
in active markets for identical assets or liabilities.
Level 2 – other significant
observable inputs for the assets or liabilities through corroboration with market data at the measurement date.
Level 3 – significant
unobservable inputs that reflect management’s best estimate of what market participants would use to price the assets or liabilities
at the measurement date.
At June 30, 2023 and
December 31, 2022, the Company categorized its restricted cash of $50,000
as Level 2 hierarchy. The assets classified as Level 2 have initially been valued at the applicable transaction price and
subsequently valued, at the end of each reporting period, using other market observable data. Observable market data points include
quoted prices, interest rates, reportable trades and other industry and economic events.
The carrying amounts of cash,
accounts payable and accrued expenses of the Company approximate their fair values due to their short-term nature.
4. Leases
In January 2019, the Company
amended the lease for its corporate headquarters and primary research facility in Marlborough, Massachusetts. The lease is for a total
of 7,581 square feet of office and laboratory space and will expire on March 31, 2024. The lease contains an option to terminate after
two or three years by providing advance written notice of termination pursuant to the terms of the agreement. The exercise of this option
was not determined to be reasonably certain and thus was not included in the lease liability on the Company’s balance sheet. The
Company did not exercise its option to terminate in either the second or third year of the lease, and the option to terminate has expired.
Additionally, the lease agreement did not contain information to determine the borrowing rate implicit in the lease. As such, the Company
calculated its incremental borrowing rate based on what the Company would have to pay to borrow on a collateralized basis over the lease
term for an amount equal to the remaining lease payments, taking into consideration such assumptions as, but not limited to, the U.S.
treasury yield rate and borrowing rates from a creditworthy financial institution using the above lease factors.
The lease for the Company’s
corporate headquarters represents all of our significant lease obligations. The amounts reported in the condensed consolidated balance
sheets for the operating lease in which the Company is the lessee and other supplemental balance sheet information is set forth as follows,
in thousands, except the lease term (number of years) and discount rate:
Schedule of lease and supplemental balance sheet information | |
| | |
| |
| |
June 30, 2023 | | |
December 31, 2022 | |
Assets | |
| | | |
| | |
Right of use asset | |
$ | 98 | | |
$ | 161 | |
Liabilities | |
| | | |
| | |
Lease liability, current | |
| 104 | | |
| 135 | |
Lease liability, non-current | |
| – | | |
| 35 | |
Total lease liability | |
$ | 104 | | |
$ | 170 | |
Lease Term and Discount Rate | |
| | | |
| | |
Weighted average remaining lease term | |
| 0.75 | | |
| 1.25 | |
Weighted average discount rate | |
| 4.70% | | |
| 4.70% | |
Operating lease costs included
in operating expense were $33,000 for the
three months ended June 30, 2023 and 2022. Operating lease costs included in operating expense were $66,000
for the six months ended June 30, 2023 and 2022.
Cash paid for the amounts
included in the measurement of the operating lease liability on the Company’s condensed consolidated balance sheets and included
within changes in the lease liability in the operating activities of the Company’s condensed consolidated statements of cash flows
was $35,000 and $34,000 for the three months ended June 30, 2023 and 2022, respectively. Cash paid for
the amounts included in the measurement of the operating lease liability on the Company’s condensed consolidated balance sheets
and included within changes in the lease liability in the operating activities of the Company’s condensed consolidated statements
of cash flow was $69,000 and $67,000 for the six months ended June 30, 2023 and 2022, respectively.
Future lease payments for
the Company’s non-cancellable operating lease and a reconciliation to the carrying amount of the operating lease liability presented
in the condensed consolidated balance sheet as of June 30, 2023 is as follows, in thousands:
Schedule of future minimum lease payments | |
| |
2023 (remaining) | |
$ | 71 | |
2024 | |
| 35 | |
Total lease payments | |
| 106 | |
Less: Imputed interest | |
| (2 | ) |
Total operating lease liability | |
$ | 104 | |
5. Preferred Stock
The Company has
authorized up to 10,000,000 shares of preferred stock, $0.0001 par value per share, for issuance. The Company’s Board of
Directors (the “Board’) is authorized under the Company’s Amended and Restated Articles of Incorporation
(as may be amended and/or restated from time to time, the “Amended Certificate”), to designate the authorized
preferred stock into one or more series and to fix and determine such rights, preferences, privileges and restrictions of any series
of preferred stock, including voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences,
as shall be determined by the Board upon its issuance.
On November 16, 2022,
the Company issued and sold one share of the Company’s Series D Preferred Stock, par value $0.0001 per
share (the “Series D Preferred Stock”) to Robert Bitterman, then its interim Executive Chairman and current Chief
Executive Officer, for $1,750.
The Series D Preferred Stock was entitled to 17,500,000 votes per share exclusively with respect to any proposal to amend the
Company’s Amended Certificate to effect a reverse stock split of the Company’s common stock (“Reverse Stock
Split”). The terms of the Series D Preferred Stock provided that it would be voted, without action by the holder, on any
such proposal in the same proportion as shares of the Company’s common stock were voted. The Series D Preferred Stock
otherwise had no voting rights except as required by the General Corporation Law of the State of Delaware.
The Series D Preferred Stock
was not convertible into, or exchangeable for, shares of any other class or series of stock or other securities of the Company. The Series
D Preferred Stock had no rights with respect to any distribution of assets of the Company, including upon a liquidation, bankruptcy, reorganization,
merger, acquisition, sale, dissolution or winding up of the Company, whether voluntarily or involuntarily. The holder of the Series D
Preferred Stock was not entitled to receive dividends of any kind.
Under its terms, the outstanding
share of Series D Preferred Stock was to be redeemed in whole, but not in part, at any time: (i) if such redemption was approved by the
Board in its sole discretion or (ii) automatically and effective upon the approval by the Company's stockholders of a Reverse Stock Split.
Upon such redemption, the holder of the Series D Preferred Stock was entitled to receive consideration of $1,750 in cash.
The Series D Preferred Stock
was redeemed in whole on January 4, 2023, upon the approval by the Company’s stockholders of a Reverse Stock Split, such that, at
June 30, 2023, there were no shares of Series D Preferred Stock authorized, issued or outstanding and all of the Company’s authorized
shares of preferred stock were undesignated.
6. Stockholders’ Equity
April 2023
Financing — On April 20, 2023, the Company completed a registered direct offering and a concurrent private placement of a
total of: 353,983
registered shares of the Company’s common stock at a purchase price per share of $5.65,
unregistered five and one-half year term Series A warrants to purchase up to 353,983
shares of common stock at an exercise price of $5.40
per share and unregistered eighteen month term Series B warrants to purchase up to 353,983
shares of common stock at an exercise price of $5.40
per share (collectively, the “April 2023 Financing”). In addition, the Company issued unregistered warrants to
the placement agent, H.C. Wainwright & Co., LLC (“HCW”), in the April 2023 Financing to purchase a total of 26,549
shares of common stock at an exercise price of $7.0625
per share. Net proceeds to the Company from the April 2023 Financing were $1,538,000
after deducting placement agent fees and offering expenses.
In connection with the April
2023 Financing, the Company entered into warrant amendment agreements (the “Warrant Amendment Agreements”) with the
participating investors to amend the exercise price of certain existing warrants to purchase up to an aggregate of 191,619 shares of common
stock that were previously issued in April 2018 through January 2021, such that each of the amended warrants have an exercise price of
$5.40 per share. The Company received $24,000 as consideration in connection with the Warrant Amendment Agreements. The Company assessed
the amendments to the exercise price of the warrants under ASC Topic 815, “Derivatives and Hedging” (“ASC
815”) and determined that the amendment to the exercise price was completed in connection with and contingent on the close of
the April 2023 Financing. The increase in fair value of $293,000 related to the Warrant Amendment Agreements was recognized as an equity
issuance cost and recorded in additional paid in capital per ASC 815.
June 2023
Financing – On June 2, 2023, the Company completed a registered direct offering and a concurrent private placement of a
total of: 233,646
registered shares and 72,000
unregistered shares of the Company’s common stock each at a purchase price per share of $4.28,
unregistered pre-funded warrants to purchase up to an aggregate of 628,935
shares of common stock at a purchase price per share of $4.279
and with an exercise price of $0.001
per share, unregistered five and one-half year term Series A warrants to purchase up to an aggregate of 934,581
shares of common stock at an exercise price of $4.03
per share and unregistered eighteen month term Series B warrants to purchase up to an aggregate of 934,581
shares of common stock at an exercise price of $4.03
per share (collectively, the “June 2023 Financing”). In addition, the Company issued unregistered warrants to the
placement agent, HCW, in the June 2023 Financing to purchase a total of 70,094
shares of common stock at an exercise price of $5.35
per share. Net proceeds to the Company from the June 2023 Financing were $3,510,000
after deducting placement agent fees and offering expenses.
Warrants
The Company first assessed the warrants in the
April 2023 Financing and June 2023 Financing under the FASB ASC Topic 480, “Distinguishing Liabilities from Equity” (“ASC
480”) to determine whether they were within the scope of ASC 480. As there were no instances outside of the Company’s
control that could require cash settlement, the Company’s warrants issued in the April 2023 Financing and June 2023 Financing
were determined to be outside the scope of ASC 480.
The
Company then applied and followed the applicable accounting guidance in the FASB ASC Topic 815, “Derivatives and Hedging.”
Financial instruments are accounted for as either derivative liabilities or equity instruments depending on the specific terms of the
agreement. The warrants issued in the April 2023 Financing and June 2023 Financing did not meet the definition of a derivative instrument
as they are indexed to the Company’s common stock and classified within stockholders’ equity. Based on this determination,
the warrants issued in the April 2023 Financing and June 2023 Financing were classified within stockholders’ equity.
During the six months ended June 30, 2023, shares
of common stock issued related to exercises from the pre-funded warrants issued in the June 2023 Financing totaled 175,000. The Company
realized proceeds of $175 from the exercises of the pre-funded warrants. There were no warrants exercised during the six months ended
June 30, 2022.
The following table summarizes the Company’s
outstanding warrants, all of which are classified as equity instruments, at June 30, 2023:
Summary of outstanding warrants | |
| | |
| |
| |
Number of Shares | | |
Weighted- Average Exercise Price Per Share | |
Outstanding at December 31, 2022 | |
| 545,401 | | |
$ | 54.53 | |
Issued | |
| 3,302,706 | | |
| 4.46 | |
Exercised | |
| (175,000 | ) | |
| 0.001 | |
Expired | |
| (1,837 | ) | |
| 1,245.59 | |
Outstanding at June 30, 2023 | |
| 3,671,270 | | |
$ | 9.09 | |
The Company’s
outstanding warrants expire at various dates between October 2023 and December 2028.
7. Stock-based Compensation
Restricted Stock Units
Restricted stock units (“RSUs”)
are issued under the Company’s 2020 Long-Term Incentive Plan (the “2020 Plan”) or as inducement grants issued
outside of the 2020 Plan to new employees. RSUs are generally subject to graded vesting and the satisfaction of certain service requirements.
Upon vesting, each outstanding RSU will be settled for one share of the Company’s common stock. Employee RSU recipients may elect
to net share settle upon vesting, in which case the Company pays the employee’s income taxes due upon vesting and withholds a number
of shares of equal value. The fair value of the RSUs awarded are based upon the Company’s closing stock price at the grant date
and are expensed over the requisite service period.
The following table summarizes the activity of
the Company’s RSUs for the six months ended June 30, 2023:
Summary of RSU activity | |
| | |
| |
| |
Number of Shares | | |
Weighted- Average Grant Date Fair Value Per Share | |
Unvested units at December 31, 2022 | |
| 47,335 | | |
$ | 15.03 | |
Granted | |
| 43,500 | | |
| 5.24 | |
Vested | |
| (18,080 | ) | |
| 16.96 | |
Forfeited | |
| – | | |
| – | |
Unvested units at June 30, 2023 | |
| 72,755 | | |
$ | 8.70 | |
The weighted-average fair
value of RSUs granted during the six months ended June 30, 2023 and 2022 was $5.24 and $10.32, respectively. There were no RSU grants
during the three months ended June 30, 2023 and 2022.
Stock-based compensation
expense related to RSUs was $94,000
and $205,000
for the three and six months ended June 30, 2023, respectively. Stock-based compensation expense related to RSUs was $82,000
and $261,000
for the three and six months ended June 30, 2022, respectively.
The aggregate fair value of
awards that vested during the six months ended June 30, 2023 and 2022 was $95,000 and $128,000, respectively, which represents the market
value of the Company’s common stock on the date that the RSUs vested.
Stock Options
Stock options are available
to be issued under the 2020 Plan and are generally subject to graded vesting and the satisfaction of certain service requirements. Upon
the exercise of a stock option, the Company issues new shares and delivers them to the recipient. The Company does not expect to net share
settle to satisfy stock option exercises.
The Company used the Black-Scholes
option-pricing model to determine the fair value of all its option grants. The risk-free interest rate used for each grant was based upon
the yield on zero-coupon U.S. Treasury securities with a term similar to the expected life of the related option. The Company’s
expected stock price volatility assumption was based upon the Company’s own implied volatility. The expected life assumption used
for option grants was based upon the simplified method provided for under ASC 718. The dividend yield assumption was based upon the fact
that the Company has never paid cash dividends and presently has no intention of paying cash dividends.
The following table summarizes the activity of
the Company’s stock options for the six months ended June 30, 2023:
Summary of Stock Option Activity |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number
of Shares |
|
|
Weighted-
Average
Exercise
Price
Per Share |
|
|
Aggregate
Intrinsic
Value |
|
Balance at December 31,
2022 |
|
|
177 |
|
|
$ |
35,231.40 |
|
|
|
|
|
Granted |
|
|
– |
|
|
|
– |
|
|
|
|
|
Exercised |
|
|
– |
|
|
|
– |
|
|
|
|
|
Forfeited |
|
|
– |
|
|
|
– |
|
|
|
|
|
Expired |
|
|
(31 |
) |
|
|
118,253.58 |
|
|
|
|
|
Balance at June 30, 2023 |
|
|
146 |
|
|
$ |
17,603.40 |
|
|
$ |
– |
|
Exercisable at June 30, 2023 |
|
|
146 |
|
|
$ |
17,603.40 |
|
|
$ |
– |
|
Stock-based compensation
expense related to stock options for the three and six months ended June 30, 2022 was $1,000
and $8,000,
respectively. As of December 31, 2022, the compensation expense for all unvested stock options had been recognized in the Company’s
results of operations.
Compensation Expense Related to Equity Awards
The following table sets
forth total stock-based compensation expense for the three and six months ended June 30, 2023 and 2022, in thousands:
Schedule of stock based compensation expense | |
|
|
|
|
|
| | |
|
|
|
|
|
| |
| |
Three Months Ended | | |
Six Months Ended | |
| |
June 30, | | |
June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Research and development | |
$ | 49 | | |
$ | 53 | | |
$ | 112 | | |
$ | 109 | |
General and administrative | |
| 45 | | |
| 30 | | |
| 93 | | |
| 160 | |
Total stock-based compensation | |
$ | 94 | | |
$ | 83 | | |
$ | 205 | | |
$ | 269 | |
8. Net Loss per Common Share
Basic
net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding. Diluted net loss per
share is computed by dividing the Company’s net loss by the weighted average number of common shares outstanding and the impact
of the dilutive effect of potential common stock equivalents, except when the inclusion of such potential common stock equivalents would
be anti-dilutive. Dilutive potential common stock equivalents primarily consist of stock options, RSUs and warrants. Therefore, basic
and diluted net loss per share applicable to common stockholders were the same for all periods presented because the impact of these items
is generally anti-dilutive during periods of net loss.
The weighted average number
of common shares outstanding as of June 30, 2023 includes the pre-funded warrants issued in connection with the June 2023 Financing, the
exercise of which requires nominal consideration for the delivery of the shares of common stock.
The following table sets forth
the potential common shares excluded from the calculation of net loss per common share because their inclusion would be anti-dilutive:
Schedule of anti-dilutive stock |
|
|
|
|
|
|
|
|
June 30, |
|
|
|
2023 |
|
|
2022 |
|
Stock options |
|
|
146 |
|
|
|
175 |
|
Unvested restricted stock units |
|
|
72,755 |
|
|
|
57,248 |
|
Warrants1 |
|
|
3,217,335 |
|
|
|
545,401 |
|
Total |
|
|
3,290,236 |
|
|
|
602,824 |
|
1 The weighted average number of common shares outstanding
as of June 30, 2023 includes the pre-funded warrants issued in the June 2023 Financing because the exercise of such warrants requires
only nominal consideration. Therefore, these pre-funded warrants are not included in the table above.
ITEM 2. |
MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS |
In this report, “we,” “our,”
“ours,” “us,” “Phio” and the “Company” refers to Phio Pharmaceuticals Corp. and our subsidiary,
MirImmune, LLC and the ongoing business operations of Phio Pharmaceuticals Corp. and MirImmune, LLC, whether conducted through Phio Pharmaceuticals
Corp. or MirImmune, LLC.
This management’s discussion and analysis
of financial condition as of June 30, 2023 and results of operations for the three and six months ended June 30, 2023 and 2022 should
be read in conjunction with the audited financial statements included in our Annual Report on Form 10-K for the year ended December 31,
2022, which was filed with the Securities and Exchange Commission (the “SEC”) on March 22, 2023 (the “2022
Form 10-K”).
This report contains forward-looking statements
within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such
as “intends,” “believes,” “anticipates,” “indicates,” “plans,” “expects,”
“suggests,” “may,” “would,” “should,” “potential,” “designed to,”
“will,” “ongoing,” “estimate,” “forecast,” “target,” “predict,”
“could” and similar references, although not all forward-looking statements contain these words. Forward-looking statements
are neither historical facts nor assurances of future performance. These statements are based only on our current beliefs, expectations
and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy
and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks
and changes in circumstances that are difficult to predict and many of which are outside of our control. Risks that could cause actual
results to vary from expected results expressed in our forward-looking statements include, but are not limited to, the impact to our business
and operations by inflationary pressures, rising interest rates, recession fears, the development of our product candidates, our ability
to execute on business strategies, our ability to develop our product candidates with collaboration partners, and the success of any such
collaborations, the timeline and duration for advancing our product candidates into clinical development, results from our preclinical
and clinical activities, the timing or likelihood of regulatory filings and approvals, the success of our efforts to commercialize our
product candidates if approved, our ability to manufacture and supply our product candidates for clinical activities, and for commercial
use if approved, the scope of protection we are able to establish and maintain for intellectual property rights covering our technology
platform, and our ability to obtain future financing. Our actual results and financial condition may differ materially from those indicated
in the forward-looking statements as a result of a number of important factors, including those identified in our 2022 Form 10-K under
the heading “Risk Factors” and in other filings the Company periodically makes with the SEC. Therefore, you should not rely
on any of these forward-looking statements. Forward-looking statements contained in this Quarterly Report on Form 10-Q speak as of the
date hereof and the Company does not undertake to update any of these forward-looking statements to reflect a change in its views or events
or circumstances that occur after the date of this report except as required by law.
Overview
Phio is a clinical stage biotechnology
company whose proprietary INTASYL™ self-delivering RNAi technology platform is designed to make immune cells more effective in killing
tumor cells. We are developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the
body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems. Our efforts are focused
on developing immuno-oncology therapeutics using our INTASYL platform. We have demonstrated preclinical efficacy in both direct-to-tumor
injection and adoptive cell therapy (“ACT”) applications with our INTASYL compounds.
PH-762
PH-762 is an INTASYL compound
designed to reduce the expression of cell death protein 1 (“PD-1”). PD-1 is a protein that inhibits T cells’
ability to kill cancer cells and is a clinically validated target in immunotherapy. Decreasing the expression of PD-1 can thereby increase
the capacity of T cells, which protect the body from cancer cells and infections, to kill cancer cells.
Preclinical studies
conducted by the Company have demonstrated that direct-to-tumor application of PH-762 resulted in potent anti-tumoral effects and have
shown that direct-to-tumor treatment with PH-762 inhibits tumor growth in a dose dependent fashion in PD-1 responsive and refractory models.
Importantly, direct-to-tumor administration of PH-762 resulted in activity against distant untreated tumors, indicative of a systemic
anti-tumor response. We believe these data further support the potential for PH-762 to provide a strong local immune response without
the dose immune-related adverse effects seen with systemic antibody therapy.
In May 2023, we announced
that the U.S. Food and Drug Administration (the “FDA”) cleared our Investigational New Drug (“IND”)
application to proceed with a U.S. clinical trial of PH-762. The initial multi-center, dose-escalating, Phase 1b clinical trial under
our cleared IND is designed to evaluate the safety and tolerability of neoadjuvant use of intratumorally injected PH-762, assess the tumor
response, and determine the dose or dose range for continued study of PH-762. We plan to initiate our Phase 1b clinical trial of intratumoral
PH-762 in patients with cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma in the second half of 2023.
We intend to focus our efforts
on our U.S. clinical trial with PH-762 and have commenced winding down our first-in-human clinical trial for PH-762 in France, which was
limited to the treatment of patients with metastatic melanoma. Safety data from the initial cohort of three patients in the French clinical
trial were evaluated by a data monitoring committee in the first quarter of 2023. The safety data review disclosed no dose-limiting toxicity,
and no drug-related severe or serious adverse events.
Due to INTASYL’s ease
of administration, we have shown that our compounds can easily be incorporated into current ACT manufacturing processes. In ACT, T cells
are usually taken from a patient's own blood or tumor tissue, grown in large numbers in a laboratory, and then given back to the patient
to help the immune system fight cancer. By treating T cells with our INTASYL compounds while they are being grown in the laboratory, we
believe our INTASYL compounds can improve these immune cells to make them more effective in killing cancer. Preclinical data generated
in collaboration with AgonOx, Inc. (“AgonOx”), a private company developing a pipeline of novel immunotherapy drugs
targeting key regulators of the immune response to cancer, demonstrated that treating AgonOx’s “double positive” tumor
infiltrating lymphocytes (“DP TIL”) with PH-762 increased their tumor killing activity by two-fold.
In March 2021, we entered
into a clinical co-development collaboration agreement (the “Clinical Co-Development Agreement”) with AgonOx to develop
a T cell-based therapy using PH-762 and AgonOx’s DP TIL. Under the Clinical Co-Development Agreement, we committed to provide financial
support for development costs of up to $4 million to AgonOx for expenses incurred to conduct a Phase 1 clinical trial of PH-762 treated
DP TIL in patients with advanced melanoma and other advanced solid tumors. Phio is also eligible to receive certain future development
milestones and low single-digit sales-based royalty payments from AgonOx’s licensing of its DP TIL technology. As of June 30, 2023,
there is approximately $3,570,000 of remaining costs not yet incurred under the Clinical Co-Development Agreement.
PH-762 treated DP TIL are
being evaluated in a Phase 1 clinical trial in the United States with up to 18 patients with advanced melanoma and other advanced solid
tumors by our partner AgonOx. The primary trial objectives are to evaluate the safety and to study the potential for enhanced therapeutic
benefit from the administration of PH-762 treated DP TIL. The trial is open for the enrollment of patients.
PH-894
PH-894 is an INTASYL compound
that is designed to silence BRD4, a protein that controls gene expression in both T cells and tumor cells, thereby effecting the immune
system as well as the tumor. Intracellular and/or commonly considered “undruggable” targets, such as BRD4, represent a challenge
for small molecule and antibody therapies. Therefore, what sets this compound apart is its dual mechanism: PH-894 suppression of BRD4
in T cells results in T cell activation, and suppression of BRD4 in tumor cells results in tumors becoming more sensitive to being killed
by T cells.
Preclinical studies conducted
have demonstrated that PH-894 resulted in a strong, concentration dependent and durable silencing of BRD4 in T cells and in various cancer
cells. Similar to PH-762, preclinical studies have also shown that direct-to-tumor application of PH-894 resulted in potent and statistically
significant anti-tumoral effects against distant untreated tumors, indicative of a systemic anti-tumor response. These preclinical data
indicate that PH-894 can reprogram T cells and other cells in the tumor microenvironment to provide enhanced immunotherapeutic activity.
We have completed the IND-enabling studies and are in the process of continuing to finalize the study reports required for an IND submission
with PH-894. As a result of the reprioritization to advance our clinical trial with PH-762 in the U.S., we have elected to defer the IND
submission for PH-894.
Critical Accounting Policies and Estimates
The discussion and analysis
of our financial condition and results of operations are based upon our condensed consolidated financial statements, which have been prepared
in accordance with accounting principles generally accepted in the United States. The preparation of these condensed consolidated financial
statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses,
and related disclosure of contingent assets and liabilities. On an ongoing basis, we evaluate our estimates and base our estimates on
historical experience and various other assumptions that are believed to be reasonable under the circumstances. Actual results may differ
from these estimates under different assumptions or conditions and could have a material impact on our reported results.
There have been no material
changes to our critical accounting policies and estimates as compared to those disclosed in our 2022 Form 10-K.
Results of Operations
The following table summarizes the results of our
operations for the periods indicated, in thousands:
| |
Three Months Ended June 30, | | |
|
| |
Six Months Ended June 30, | | |
| |
Description | |
2023 | | |
2022 | | |
Dollar Change |
| |
2023 | | |
2022 | | |
Dollar Change | |
Operating expenses | |
$ | 2,547 | | |
$ | 2,521 | | |
$ | 26 |
| |
$ | 6,149 | | |
$ | 5,161 | | |
$ | 988 | |
Operating loss | |
$ | (2,547 | ) | |
$ | (2,521 | ) | |
$ | (26 |
) | |
$ | (6,149 | ) | |
$ | (5,161 | ) | |
$ | (988 | ) |
Net loss | |
$ | (2,549 | ) | |
$ | (2,531 | ) | |
$ | (18 |
) | |
$ | (6,151 | ) | |
$ | (5,173 | ) | |
$ | (978 | ) |
Comparison of the Three and Six Months Ended June 30, 2023 and 2022
Operating Expenses
The following table summarizes our total operating
expenses, for the periods indicated, in thousands:
| |
Three Months Ended June 30,
| | |
| | |
Six Months Ended June 30, | | |
| |
Description | |
2023 | | |
2022 | | |
Dollar Change | | |
2023 | | |
2022 | | |
Dollar Change | |
Research and development | |
$ | 1,383 | | |
$ | 1,304 | | |
$ | 79 | | |
$ | 3,517 | | |
$ | 2,890 | | |
$ | 627 | |
General and administrative | |
| 1,164 | | |
| 1,217 | | |
| (53 | ) | |
| 2,632 | | |
| 2,271 | | |
| 361 | |
Total operating expenses | |
$ | 2,547 | | |
$ | 2,521 | | |
$ | 26 | | |
$ | 6,149 | | |
$ | 5,161 | | |
$ | 988 | |
Research
and Development Expenses
Research and development expenses
relate to compensation and benefits for research and development personnel, facility-related expenses, supplies, external services, costs
to acquire technology licenses, research activities under our research collaboration, expenses associated with preclinical and clinical
development activities and other operating costs. Our research and development programs are focused on the development of immuno-oncology
therapeutics based on our INTASYL therapeutic platform. Since we commenced operations, research and development expenses have been a significant
portion of our total operating expenses and are expected to constitute the majority of our spending for the foreseeable future.
Research and development expenses
for the three months ended June 30, 2023 increased 6% as compared to the three months ended June 30, 2022. The increase in research and
development expenses was primarily due to increased clinical-related costs of approximately $329,000 to support the two PH-762 Phase 1
clinical trials in the U.S., partially offset by decreased costs related to the completion of the Company’s IND-enabling preclinical
studies for PH-894 of approximately $207,000 as compared to the prior year period.
Research and development expenses
for the six months ended June 30, 2023 increased 22% as compared to the six months ended June 30, 2022. The increase in research and development
expenses was primarily due to increased clinical-related costs to support the two PH-762 Phase 1 clinical trials in the U.S. of approximately
$789,000, partially offset by decreased lab supply costs of $92,000 as a result of a change in headcount as compared to the prior year
period.
We anticipate research and
development expenses to continue to increase as a result of clinical-related activities as our pipeline programs progress in clinical
development.
General and Administrative Expenses
General and administrative
expenses relate to compensation and benefits for general and administrative personnel, facility-related expenses, professional fees for
legal and patent-related activities, audit, tax and consulting services, as well as other general corporate expenses.
General and administrative
expenses for the three months ended June 30, 2023 decreased 4% as compared to the three months ended June 30, 2022. The decrease was primarily
due to a total net reduction of approximately $28,000 in payroll-related expenses as a result of the changes in the Company’s Chief
Executive Officer (“CEO”) position as compared to the prior year period.
General
and administrative expenses for the six months ended June 30, 2023 increased 16% as compared to the six months ended June 30, 2022. The
increase in general and administrative expenses was primarily due to higher legal fees of approximately $378,000, partially offset by
a total net reduction of approximately $52,000 in payroll-related expenses as a result of the changes in the Company’s CEO
position as compared to the prior year period.
Liquidity and Capital Resources
Historically, our primary
source of funding has been through the sale of our securities. In the future, we will be dependent on obtaining funding from third parties,
such as proceeds from the issuance of debt, sale of equity or strategic opportunities, in order to maintain our operations. We have reported
recurring losses from operations since inception and expect that we will continue to have negative cash flows from our operations for
the foreseeable future. At June 30, 2023, we had cash of $11,307,000 as compared with $11,781,000 at December 31, 2022.
During the quarterly period
ended June 30, 2023, we completed the April 2023 Financing and June 2023 Financing (each as defined in Note 6 to our condensed consolidated
interim financial statements) and received total net proceeds of $5,048,000 after deducting placement agent fees and offering expenses.
For further information regarding the April 2023 Financing and June 2023 Financing, see Note 6 to our condensed consolidated interim financial
statements included elsewhere in this Quarterly Report.
We have limited cash resources,
have reported recurring losses from operations since inception and has not yet received product revenues. These factors raise substantial
doubt regarding our ability to continue as a going concern, and our current cash resources may not provide sufficient capital to fund
operations for at least the next 12 months from the date of the release of the financial statements included elsewhere in this Quarterly
Report. Our continuation as a going concern depends upon our ability to raise additional capital through equity offerings, debt offerings
and/or strategic opportunities to fund our operations. There can be no assurance that we will be successful in accomplishing any of these
plans in order to continue as a going concern. The financial statements included elsewhere in this Quarterly Report do not include any
adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary
should we be unable to continue as a going concern.
The following table summarizes
our cash flows for the periods indicated, in thousands:
| |
Six Months Ended
June 30, | |
| |
2023 | | |
2022 | |
Net cash used in operating activities | |
$ | (5,479 | ) | |
$ | (5,898 | ) |
Net cash used in investing activities | |
| (5 | ) | |
| (114 | ) |
Net cash provided by (used in) financing activities | |
| 5,010 | | |
| (25 | ) |
Net decrease in cash and restricted cash | |
$ | (474 | ) | |
$ | (6,037 | ) |
Net Cash Flow from Operating Activities
Net cash used in operating
activities for the six months ended June 30, 2023 decreased by 7% as compared to the six months ended June 30, 2022, primarily due to
decreased cash outflow from changes in operating assets and liabilities of $1,468,000 as a result of liabilities owed for the payments
related to the IND-enabling studies with PH-894 and clinical supply manufacturing of PH-762 and PH-894 in the prior year period partially
offset by an increase in net loss of $978,000.
Net Cash Flow from Investing Activities
Net cash used in investing
activities for the six months ended June 30, 2023 decreased 96% as compared to the six months ended June 30, 2022, primarily due to changes
in laboratory and computer equipment purchases for our facility over the period.
Net Cash Flow from Financing Activities
Net cash provided by financing
activities for the six months ended June 30, 2023 increased as compared to the net cash used in financing activities for the six
months ended June 30, 2022, primarily due to the completion of the Company’s April 2023 Financing and June 2023 Financing.
Contractual Obligations
There have been no material
changes to the contractual obligations as disclosed in our 2022 Form 10-K. Details of our obligations under the Clinical Co-Development
Agreement with our partner AgonOx as of June 30, 2023 can be found in Note 2 of the condensed consolidated interim financial statements
included elsewhere in this Quarterly Report.
ITEM 3. |
QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK |
As a smaller reporting company,
we are not required to provide this information.
ITEM 4. |
CONTROLS AND PROCEDURES |
Evaluation of Disclosure Controls and Procedures
Our management, with the participation
of our Principal Executive Officer (who is also acting as our Principal Financial Officer), evaluated the effectiveness of disclosure
controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange
Act”)) as of the end of the period covered by this report to ensure that information that we are required to disclose in reports
that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the
Securities and Exchange Commission’s rules and forms.
Our disclosure controls and
procedures are designed to provide reasonable assurance of achieving their objectives. We believe that a control system, no matter how
well designed and operated, cannot provide absolute assurance that the objectives of the control system are met, and no evaluation of
controls can provide absolute assurance that all control issues and instances of fraud, if any, within a company have been detected. Based
on the evaluation of our disclosure controls and procedures as of the end of the period covered by this report, management, with the participation
of our Principal Executive Officer (who is also acting as our Principal Financial Officer), concluded that our disclosure controls and
procedures were effective at the reasonable assurance level as of such date.
Changes in Internal Control Over Financial
Reporting
There have been no changes
in our internal control over financial reporting that occurred during the quarter ending June 30, 2023 that have materially affected,
or are reasonably likely to materially affect, our internal control over financial reporting.
PART II — OTHER INFORMATION
ITEM 1. |
LEGAL PROCEEDINGS |
From time to time, the Company
may become a party to various legal proceedings and complaints arising in the ordinary course of business. We are not currently a party
to any actual or threatened material legal proceedings of which we are aware.
There have been no material
changes in our risk factors set forth in Part I, “Item 1A. Risk Factors” in our 2022 Form 10-K. The risk factors disclosed
in Part I, “Item 1A. Risk Factors” in our 2022 Form 10-K could materially adversely affect our business, financial condition,
or results of operations. This Quarterly Report on Form 10-Q also contains forward-looking statements that involve risks and uncertainties.
Our actual results could differ materially from those anticipated in these forward-looking statements as a result of certain factors,
including these risks. Additional risks not currently known or currently material to us may also harm our business.
ITEM 2. |
UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS |
No sales or issuances of unregistered securities
occurred that have not previously been disclosed in a Current Report on Form 8-K.
ITEM 3. |
DEFAULTS UPON SENIOR SECURITIES |
None.
ITEM 4. |
MINE SAFETY DISCLOSURES |
Not applicable.
ITEM 5. |
OTHER INFORMATION |
None.
EXHIBIT INDEX
|
|
Incorporated by Reference Herein |
Exhibit
Number |
Description |
Form |
|
Date |
|
|
|
|
|
3.1 |
Amended and Restated Certificate of Incorporation of Phio Pharmaceuticals Corp. |
Current Report on Form 8-K (File No. 001-36304) |
|
November 19, 2018 |
3.2 |
Certificate of Amendment to the Amendment and Restated Certificate of Incorporation of Phio Pharmaceuticals Corp. |
Current Report on Form 8-K (File No. 001-36304) |
|
January 14, 2020 |
3.3 |
Certificate of Amendment to the Amendment and Restated Certificate of Incorporation of Phio Pharmaceuticals Corp. |
Current Report on Form 8-K (File No. 001-36304) |
|
January 25, 2023 |
3.4 |
Certificate of Designation of Series D Preferred Stock, dated November 16, 2022. |
Current Report on Form 8-K (File No. 001-36304) |
|
November 16, 2022 |
4.1 |
Form of Series A Common Stock Warrant, dated April 20, 2023. |
Current Report on Form 8-K (File No. 001-36304) |
|
April 20, 2023 |
4.2 |
Form of Series B Common Stock Warrant, dated April 20, 2023. |
Current Report on Form 8-K (File No. 001-36304) |
|
April 20, 2023 |
4.3 |
Form of Existing Warrant Amendment, dated April 28, 2023. |
Current Report on Form 8-K (File No. 001-36304) |
|
April 20, 2023 |
4.4 |
Form of Series A Common Stock Warrant, dated June 2, 2023. |
Current Report on Form 8-K (File No. 001-36304) |
|
June 2, 2023 |
4.5 |
Form of Series B Common Stock Warrant, dated June 2, 2023. |
Current Report on Form 8-K (File No. 001-36304) |
|
June 2, 2023 |
4.6 |
Form of Pre-funded Common Stock Warrant, dated June 2, 2023. |
Current Report on Form 8-K (File No. 001-36304) |
|
June 2, 2023 |
10.1 |
Form of Securities Purchase Agreement, dated April 18, 2023, by and
between the Company and each of the Purchasers signatory thereto. |
Current Report on Form 8-K (File No. 001-36304) |
|
April 20, 2023 |
10.2 |
Form of Securities Purchase Agreement, dated May 31, 2023, by and between
the Company and each of the Purchasers signatory thereto (Registered Direct Offering). |
Current Report on Form 8-K (File No. 001-36304) |
|
June 2, 2023 |
10.3 |
Form of Securities Purchase Agreement, dated May 31, 2023, by and between
the Company and each of the Purchasers signatory thereto (PIPE Private Placement). |
Current Report on Form 8-K (File No. 001-36304) |
|
June 2, 2023 |
10.4 |
Form of Registration Rights Agreement, dated May 31, 2023, by and between
the Company and each of the Purchasers signatory thereto. |
Current Report on Form 8-K (File No. 001-36304) |
|
June 2, 2023 |
31.1 |
Sarbanes-Oxley Act Section 302 Certification of Principal Executive Officer and Principal Financial Officer. * |
|
|
|
32.1 |
Sarbanes-Oxley Act Section 906 Certification of Principal Executive Officer and Principal Financial Officer. ** |
|
|
|
|
|
|
|
|
101.INS |
Inline XBRL Instance Document.* |
|
|
|
101.SCH |
Inline XBRL Taxonomy Extension Schema Document.* |
|
|
|
101.CAL |
Inline XBRL Taxonomy Extension Calculation Linkbase Document.* |
|
|
|
101.DEF |
Inline XBRL Taxonomy Extension Definition Linkbase Document.* |
|
|
|
101.LAB |
Inline XBRL Taxonomy Extension Label Linkbase Document.* |
|
|
|
101.PRE |
Inline XBRL Taxonomy Extension Presentation Linkbase Document.* |
|
|
|
104 |
The cover page for this report, formatted in Inline XBRL (included in Exhibit 101).* |
|
|
|
|
|
|
|
|
|
* |
Filed herewith. |
|
** |
Furnished herewith and not deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liability of that Section or incorporated by reference into any filing under the Securities Act or the Exchange Act. |
SIGNATURES
Pursuant to the requirements of the Securities
Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
|
|
|
|
|
Phio Pharmaceuticals Corp. |
|
|
|
|
By: |
|
/s/ Robert J. Bitterman |
|
|
|
Robert J. Bitterman |
|
|
|
President and Chief Executive Officer
(as Principal Executive and Financial Officer) |
|
|
|
|
|
|
Date: August 10, 2023 |
Exhibit 31.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
AND PRINCIPAL FINANCIAL OFFICER
PURSUANT TO
SECURITIES EXCHANGE ACT OF 1934 RULES 13a-14(a)
AND 15d-14(a)
AS ADOPTED
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY
ACT OF 2002
I, Robert J. Bitterman, certify that:
|
1. |
I have reviewed this Quarterly Report on Form 10-Q of Phio Pharmaceuticals Corp.; |
|
2. |
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; |
|
3. |
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report; |
|
4. |
I am responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a–15(f) and 15d–15(f)) for the registrant and have: |
|
a. |
Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under my supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to me by others within those entities, particularly during the period in which this report is being prepared; |
|
b. |
Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under my supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles; |
|
c. |
Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report my conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and |
|
d. |
Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and |
|
5. |
I have disclosed, based on my most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions): |
|
a. |
All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and |
|
b. |
Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal controls over financial reporting. |
Dated: August 10, 2023
|
|
/s/ Robert J. Bitterman |
|
Robert J. Bitterman |
|
President and Chief Executive Officer |
|
(as Principal Executive and Financial Officer) |
Exhibit 32.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
AND PRINCIPAL FINANCIAL OFFICER
PURSUANT TO
18 U.S.C. SECTION 1350
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report of Phio Pharmaceuticals Corp.
(the “Company”) on Form 10-Q for the period ended June 30, 2023 as filed with the Securities and Exchange Commission on the
date hereof (the “Report”), the undersigned officer of the Company certifies, pursuant to 18 U.S.C. §1350, as adopted
pursuant to §906 of the Sarbanes-Oxley Act of 2002, that to their knowledge:
|
1. |
The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and |
|
2. |
The information contained in the Report fairly presents, in all material respects, the Company’s financial condition and result of operations. |
Dated: August 10, 2023
|
|
/s/ Robert J. Bitterman |
|
Robert J. Bitterman |
|
President and Chief Executive Officer |
|
(as Principal Executive and Financial Officer) |
v3.23.2
Cover - shares
|
6 Months Ended |
|
Jun. 30, 2023 |
Aug. 04, 2023 |
Cover [Abstract] |
|
|
Document Type |
10-Q
|
|
Amendment Flag |
false
|
|
Document Quarterly Report |
true
|
|
Document Transition Report |
false
|
|
Document Period End Date |
Jun. 30, 2023
|
|
Document Fiscal Period Focus |
Q2
|
|
Document Fiscal Year Focus |
2023
|
|
Current Fiscal Year End Date |
--12-31
|
|
Entity File Number |
001-36304
|
|
Entity Registrant Name |
Phio Pharmaceuticals Corp.
|
|
Entity Central Index Key |
0001533040
|
|
Entity Tax Identification Number |
45-3215903
|
|
Entity Incorporation, State or Country Code |
DE
|
|
Entity Address, Address Line One |
257 Simarano Drive
|
|
Entity Address, Address Line Two |
Suite 101
|
|
Entity Address, City or Town |
Marlborough
|
|
Entity Address, State or Province |
MA
|
|
Entity Address, Postal Zip Code |
01752
|
|
City Area Code |
(508)
|
|
Local Phone Number |
767-3861
|
|
Title of 12(b) Security |
Common Stock, par value, $0.0001 per share
|
|
Trading Symbol |
PHIO
|
|
Security Exchange Name |
NASDAQ
|
|
Entity Current Reporting Status |
Yes
|
|
Entity Interactive Data Current |
Yes
|
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Entity Filer Category |
Non-accelerated Filer
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Entity Small Business |
true
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Entity Emerging Growth Company |
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Entity Shell Company |
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Entity Common Stock, Shares Outstanding |
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v3.23.2
CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands |
Jun. 30, 2023 |
Dec. 31, 2022 |
Current assets: |
|
|
Cash |
$ 11,307
|
$ 11,781
|
Restricted cash |
50
|
50
|
Prepaid expenses and other current assets |
678
|
615
|
Total current assets |
12,035
|
12,446
|
Right of use asset |
98
|
161
|
Property and equipment, net |
157
|
183
|
Other assets |
6
|
24
|
Total assets |
12,296
|
12,814
|
Current liabilities: |
|
|
Accounts payable |
641
|
779
|
Accrued expenses |
1,647
|
1,025
|
Lease liability |
104
|
135
|
Total current liabilities |
2,392
|
1,939
|
Lease liability, net of current portion |
0
|
35
|
Total liabilities |
2,392
|
1,974
|
Commitments and contingencies (Note 2) |
|
|
Series D Preferred Stock, $0.0001 par value; 0 and 1 shares authorized, issued and outstanding at June 30, 2023 and December 31, 2022, respectively |
0
|
2
|
Stockholders’ equity: |
|
|
Common stock, $0.0001 par value, 100,000,000 shares authorized; 1,985,211 and 1,139,024 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively |
0
|
0
|
Additional paid-in capital |
144,435
|
139,218
|
Accumulated deficit |
(134,531)
|
(128,380)
|
Total stockholders’ equity |
9,904
|
10,838
|
Total liabilities, preferred stock and stockholders’ equity |
$ 12,296
|
$ 12,814
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v3.23.2
CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical) - $ / shares
|
Jun. 30, 2023 |
Dec. 31, 2022 |
Statement of Financial Position [Abstract] |
|
|
Temporary Equity, Par or Stated Value Per Share |
$ 0.0001
|
$ 0.0001
|
Temporary Equity, Shares Authorized |
0
|
1
|
Temporary Equity, Shares Issued |
0
|
1
|
Temporary Equity, Shares Outstanding |
0
|
1
|
Common Stock, Par or Stated Value Per Share |
$ 0.0001
|
$ 0.0001
|
Common Stock, Shares Authorized |
100,000,000
|
100,000,000
|
Common Stock, Shares, Issued |
1,985,211
|
1,139,024
|
Common Stock, Shares, Outstanding |
1,985,211
|
1,139,024
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v3.23.2
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Operating expenses: |
|
|
|
|
Research and development |
$ 1,383
|
$ 1,304
|
$ 3,517
|
$ 2,890
|
General and administrative |
1,164
|
1,217
|
2,632
|
2,271
|
Total operating expenses |
2,547
|
2,521
|
6,149
|
5,161
|
Operating loss |
(2,547)
|
(2,521)
|
(6,149)
|
(5,161)
|
Total other expense, net |
(2)
|
(10)
|
(2)
|
(12)
|
Net loss |
$ (2,549)
|
$ (2,531)
|
$ (6,151)
|
$ (5,173)
|
X |
- DefinitionThe aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.
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v3.23.2
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) (Parenthetical) - $ / shares shares in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Income Statement [Abstract] |
|
|
|
|
Earnings Per Share, Basic |
$ (1.47)
|
$ (2.22)
|
$ (4.28)
|
$ (4.56)
|
Earnings Per Share, Diluted |
$ (1.47)
|
$ (2.22)
|
$ (4.28)
|
$ (4.56)
|
Weighted Average Number of Shares Outstanding, Basic |
1,728,490
|
1,138,227
|
1,436,971
|
1,134,307
|
Weighted Average Number of Shares Outstanding, Diluted |
1,728,490
|
1,138,227
|
1,436,971
|
1,134,307
|
X |
- DefinitionThe amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.
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v3.23.2
CONDENSED CONSOLIDATED STATEMENTS OF PREFERRED STOCK AND STOCKHOLDERS' EQUITY (Unaudited) - USD ($) $ in Thousands |
Preferred Stock Series D [Member] |
Common Stock [Member] |
Additional Paid-in Capital [Member] |
Retained Earnings [Member] |
Total |
Beginning balance, value at Dec. 31, 2021 |
$ 0
|
$ 0
|
$ 138,832
|
$ (116,900)
|
$ 21,932
|
Balance at ending, shares at Dec. 31, 2021 |
0
|
1,127,917
|
|
|
|
Issuance of common stock upon vesting of restricted stock units |
|
|
|
|
|
Issuance of common stock upon vesting of restricted stock units, shares |
|
12,943
|
|
|
|
Shares withheld for payroll taxes |
|
|
(25)
|
|
(25)
|
Shares withheld for payroll taxes, shares |
|
(2,633)
|
|
|
|
Stock-based compensation expense |
|
|
186
|
|
186
|
Net loss |
|
|
|
(2,642)
|
(2,642)
|
Ending balance, value at Mar. 31, 2022 |
$ 0
|
$ 0
|
138,993
|
(119,542)
|
19,451
|
Balance at ending, shares at Mar. 31, 2022 |
0
|
1,138,227
|
|
|
|
Beginning balance, value at Dec. 31, 2021 |
$ 0
|
$ 0
|
138,832
|
(116,900)
|
21,932
|
Balance at ending, shares at Dec. 31, 2021 |
0
|
1,127,917
|
|
|
|
Net loss |
|
|
|
|
(5,173)
|
Ending balance, value at Jun. 30, 2022 |
$ 0
|
$ 0
|
139,076
|
(122,073)
|
17,003
|
Balance at ending, shares at Jun. 30, 2022 |
0
|
1,138,227
|
|
|
|
Beginning balance, value at Mar. 31, 2022 |
$ 0
|
$ 0
|
138,993
|
(119,542)
|
19,451
|
Balance at ending, shares at Mar. 31, 2022 |
0
|
1,138,227
|
|
|
|
Stock-based compensation expense |
|
|
83
|
|
83
|
Net loss |
|
|
|
(2,531)
|
(2,531)
|
Ending balance, value at Jun. 30, 2022 |
$ 0
|
$ 0
|
139,076
|
(122,073)
|
17,003
|
Balance at ending, shares at Jun. 30, 2022 |
0
|
1,138,227
|
|
|
|
Beginning balance, value at Dec. 31, 2022 |
$ 2
|
$ 0
|
139,218
|
(128,380)
|
10,838
|
Balance at ending, shares at Dec. 31, 2022 |
1
|
1,139,024
|
|
|
|
Cash-in-lieu of fractional shares for reverse stock split |
|
|
(11)
|
|
(11)
|
Cash-in-lieu of fractional shares for reverse stock split, shares |
|
(1,706)
|
|
|
|
Redemption of preferred stock |
$ (2)
|
$ 0
|
0
|
0
|
0
|
Redemption of preferred stock, shares |
(1)
|
|
|
|
|
Issuance of common stock upon vesting of restricted stock units |
$ 0
|
$ 0
|
0
|
0
|
0
|
Issuance of common stock upon vesting of restricted stock units, shares |
|
18,080
|
|
|
|
Shares withheld for payroll taxes |
|
|
(25)
|
|
(25)
|
Shares withheld for payroll taxes, shares |
|
(4,816)
|
|
|
|
Stock-based compensation expense |
|
|
111
|
|
111
|
Net loss |
|
|
|
(3,602)
|
(3,602)
|
Ending balance, value at Mar. 31, 2023 |
$ 0
|
$ 0
|
139,293
|
(131,982)
|
7,311
|
Balance at ending, shares at Mar. 31, 2023 |
0
|
1,150,582
|
|
|
|
Beginning balance, value at Dec. 31, 2022 |
$ 2
|
$ 0
|
139,218
|
(128,380)
|
10,838
|
Balance at ending, shares at Dec. 31, 2022 |
1
|
1,139,024
|
|
|
|
Net loss |
|
|
|
|
(6,151)
|
Ending balance, value at Jun. 30, 2023 |
$ 0
|
$ 0
|
144,435
|
(134,531)
|
9,904
|
Balance at ending, shares at Jun. 30, 2023 |
0
|
1,985,211
|
|
|
|
Beginning balance, value at Mar. 31, 2023 |
$ 0
|
$ 0
|
139,293
|
(131,982)
|
7,311
|
Balance at ending, shares at Mar. 31, 2023 |
0
|
1,150,582
|
|
|
|
Stock-based compensation expense |
|
|
94
|
|
94
|
Net loss |
|
|
|
(2,549)
|
(2,549)
|
Issuance of common stock and warrants, net of offering costs |
|
|
5,048
|
|
5,048
|
Issuance of common stock and warrants, shares |
|
659,629
|
|
|
|
Issuance of common stock upon exercise of warrants |
0
|
$ 0
|
0
|
0
|
0
|
Issuance of common stock upon exercise of warrants, shares |
|
175,000
|
|
|
|
Ending balance, value at Jun. 30, 2023 |
$ 0
|
$ 0
|
$ 144,435
|
$ (134,531)
|
$ 9,904
|
Balance at ending, shares at Jun. 30, 2023 |
0
|
1,985,211
|
|
|
|
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v3.23.2
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Cash flows from operating activities: |
|
|
Net loss |
$ (6,151)
|
$ (5,173)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Depreciation and amortization |
31
|
41
|
Amortization of right of use asset |
63
|
60
|
Stock-based compensation |
205
|
269
|
Changes in operating assets and liabilities: |
|
|
Prepaid expenses and other assets |
(45)
|
(998)
|
Accounts payable |
(138)
|
865
|
Accrued expenses |
622
|
(901)
|
Lease liability |
(66)
|
(61)
|
Net cash used in operating activities |
(5,479)
|
(5,898)
|
Cash flows from investing activities: |
|
|
Cash paid for purchase of property and equipment |
(5)
|
(114)
|
Net cash used in investing activities |
(5)
|
(114)
|
Cash flows from financing activities: |
|
|
Net proceeds from the issuance of common stock and warrants |
5,048
|
0
|
Cash in lieu of fractional shares for reverse stock split |
(11)
|
0
|
Redemption of Series D preferred stock |
(2)
|
0
|
Payment of taxes on net share settlements of restricted stock units |
(25)
|
(25)
|
Net cash provided by (used in) financing activities |
5,010
|
(25)
|
Net decrease in cash and restricted cash |
(474)
|
(6,037)
|
Cash and restricted cash at the beginning of period |
11,831
|
24,107
|
Cash and restricted cash at the end of period |
$ 11,357
|
$ 18,070
|
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v3.23.2
Reconciliation of Cash - USD ($) $ in Thousands |
Jun. 30, 2023 |
Dec. 31, 2022 |
Jun. 30, 2022 |
Dec. 31, 2021 |
Statement of Financial Position [Abstract] |
|
|
|
|
Cash |
$ 11,307
|
$ 11,781
|
$ 18,020
|
|
Restricted cash |
50
|
50
|
50
|
|
Cash and restricted cash |
$ 11,357
|
$ 11,831
|
$ 18,070
|
$ 24,107
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v3.23.2
Organization and Significant Accounting Policies
|
6 Months Ended |
Jun. 30, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Organization and Significant Accounting Policies |
1. Organization and Significant Accounting Policies
Nature of Operations
Phio Pharmaceuticals Corp. (“Phio”
or the “Company”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology
platform is designed to make immune cells more effective in killing tumor cells. Phio is developing therapeutics that are designed to
leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized
formulations or drug delivery systems.
Effective January 26, 2023, the Company completed
a 1-for-12 reverse stock split of the Company’s outstanding common stock, including reclassifying an amount equal to the reduction
in par value to additional paid-in capital. The reverse stock split did not reduce the number of authorized shares of the Company’s
common or preferred stock. All share and per share amounts have been adjusted to give effect to the reverse stock split.
Principles of Consolidation
The condensed consolidated
financial statements include the accounts of Phio and its wholly-owned subsidiary, MirImmune, LLC. All material intercompany accounts
have been eliminated in consolidation.
Basis of Presentation
The accompanying condensed consolidated financial statements are unaudited
and have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”). Certain
information and footnote disclosures that are included in the Company’s annual consolidated financial statements, but that are not
required for interim reporting purposes, have been condensed or omitted. Additionally, the Company made adjustments to the outstanding
stock option and unvested restricted stock unit balances, and related per share amounts, at December 31, 2022 to reflect final revisions
to these outstanding equity awards as a result of the Company’s reverse stock split. The adjustment had no effect on the Company’s
condensed consolidated financial statements. These statements should be read in conjunction with the audited consolidated financial statements
and notes thereto included in the Company’s most recent Annual Report on Form 10-K for the year ended December 31, 2022, as filed
with the Securities and Exchange Commission (the “SEC”) on March 22, 2023 (the “2022 Form 10-K”).
In the opinion of management, all adjustments (including normal recurring accruals) considered necessary for a fair presentation of the
condensed consolidated financial statements have been included. Interim results are not necessarily indicative of results for a full year.
Use of Estimates
The preparation of financial
statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and
liabilities and disclosure of contingent assets and liabilities as of the date of the financial statements and the reported amounts of
revenues and expenses during the reporting period. The areas subject to significant estimates and judgement include, among others, those
related to the fair value of equity awards, accruals for research and development expenses, useful lives of property and equipment, income
taxes, and the valuation allowance on the Company’s deferred tax assets. On an ongoing basis the Company evaluates its estimates
and bases its estimates on historical experience and other relevant assumptions that the Company believes are reasonable under the circumstances.
Actual results could differ materially from these estimates.
Liquidity
The Company has reported recurring
losses from operations since inception and expects to continue to have negative cash flows from operations for the foreseeable future.
Historically, the Company’s primary source of funding has been from sales of its securities. The Company’s ability to continue
to fund its operations is dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity,
or strategic opportunities, in order to maintain its operations. This is dependent on a number of factors, including the market demand
or liquidity of the Company’s common stock. There is no guarantee that debt, additional equity or other funding will be available
to the Company on acceptable terms, or at all. If the Company fails to obtain additional funding when needed, the Company would be forced
to scale back or terminate its operations or seek to merge with or to be acquired by another company.
The Company has limited cash
resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise
substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources
may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial
statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through
an equity offering, debt offering and/or strategic opportunity to fund its operations. There can be no assurance that the Company will
be successful in accomplishing these plans in order to continue as a going concern. These financial statements do not include any adjustments
to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the
Company be unable to continue as a going concern.
Summary of Significant Accounting Policies
There have been no material
changes to the significant accounting policies disclosed in the Company’s 2022 Form 10-K.
Recent Accounting Pronouncements
There have been no recent
accounting pronouncements that have significantly impacted this Quarterly Report on Form 10-Q, beyond those disclosed in the Company’s
2022 Form 10-K.
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- DefinitionThe entire disclosure for the organization, consolidation and basis of presentation of financial statements disclosure, and significant accounting policies of the reporting entity. May be provided in more than one note to the financial statements, as long as users are provided with an understanding of (1) the significant judgments and assumptions made by an enterprise in determining whether it must consolidate a VIE and/or disclose information about its involvement with a VIE, (2) the nature of restrictions on a consolidated VIE's assets reported by an enterprise in its statement of financial position, including the carrying amounts of such assets, (3) the nature of, and changes in, the risks associated with an enterprise's involvement with the VIE, and (4) how an enterprise's involvement with the VIE affects the enterprise's financial position, financial performance, and cash flows. Describes procedure if disclosures are provided in more than one note to the financial statements.
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v3.23.2
Collaboration Agreement
|
6 Months Ended |
Jun. 30, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Collaboration Agreement |
2. Collaboration Agreement
AgonOx, Inc. (“AgonOx”)
In March 2021, the
Company entered into a clinical co-development collaboration agreement (the “Clinical Co-Development Agreement”)
with AgonOx, a private company developing a pipeline of novel immunotherapy drugs targeting key regulators of the immune response to
cancer. Under the Clinical Co-Development Agreement, Phio and AgonOx are working to develop a T cell-based therapy using the
Company’s lead product candidate, PH-762, and AgonOx’s “double positive” tumor infiltrating lymphocytes
(“DP TIL”) technology. Per the terms of the Clinical Co-Development Agreement, the Company committed to provide
financial support for development costs of up to $4,000,000
to AgonOx for expenses incurred to conduct a Phase 1 clinical trial of PH-762 treated DP TIL in patients with advanced melanoma and
other advanced solid tumors.
The Company will recognize
its share of costs arising from research and development activities performed by AgonOx in the Company’s financial statements in
the period AgonOx incurs such expense. Phio will be entitled to certain future development milestones and low single-digit sales-based
royalty payments from AgonOx’s licensing of its DP TIL technology.
The Company recognized
approximately $181,000
and $300,000
of expense in connection with these efforts during the three and six months ended June 30, 2023, respectively. No
expense under the Clinical Co-Development Agreement was recognized during the three and six months ended June 30, 2022.
There is approximately $3,570,000
of remaining costs not yet incurred under the Clinical Co-Development Agreement as of June 30, 2023.
|
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- DefinitionThe entire disclosure for collaborative arrangements in which the entity is a participant, including a) information about the nature and purpose of such arrangements; b) its rights and obligations thereunder; c) the accounting policy for collaborative arrangements; and d) the income statement classification and amounts attributable to transactions arising from the collaborative arrangement between participants.
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v3.23.2
Fair Value of Financial Instruments
|
6 Months Ended |
Jun. 30, 2023 |
Fair Value Disclosures [Abstract] |
|
Fair Value of Financial Instruments |
3. Fair Value of Financial Instruments
The Company follows the provisions
of the Financial Accounting Standards Board (the “FASB”) Accounting Standards Codification (“ASC”)
Topic 820, “Fair Value Measurement,” for the Company’s financial assets and liabilities that are re-measured
and reported at fair value each reporting period and are re-measured and reported at fair value at least annually using a fair value hierarchy
that is broken down into three levels. Level inputs are defined as follows:
Level 1 – quoted prices
in active markets for identical assets or liabilities.
Level 2 – other significant
observable inputs for the assets or liabilities through corroboration with market data at the measurement date.
Level 3 – significant
unobservable inputs that reflect management’s best estimate of what market participants would use to price the assets or liabilities
at the measurement date.
At June 30, 2023 and
December 31, 2022, the Company categorized its restricted cash of $50,000
as Level 2 hierarchy. The assets classified as Level 2 have initially been valued at the applicable transaction price and
subsequently valued, at the end of each reporting period, using other market observable data. Observable market data points include
quoted prices, interest rates, reportable trades and other industry and economic events.
The carrying amounts of cash,
accounts payable and accrued expenses of the Company approximate their fair values due to their short-term nature.
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- DefinitionThe entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.
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v3.23.2
Leases
|
6 Months Ended |
Jun. 30, 2023 |
Leases [Abstract] |
|
Leases |
4. Leases
In January 2019, the Company
amended the lease for its corporate headquarters and primary research facility in Marlborough, Massachusetts. The lease is for a total
of 7,581 square feet of office and laboratory space and will expire on March 31, 2024. The lease contains an option to terminate after
two or three years by providing advance written notice of termination pursuant to the terms of the agreement. The exercise of this option
was not determined to be reasonably certain and thus was not included in the lease liability on the Company’s balance sheet. The
Company did not exercise its option to terminate in either the second or third year of the lease, and the option to terminate has expired.
Additionally, the lease agreement did not contain information to determine the borrowing rate implicit in the lease. As such, the Company
calculated its incremental borrowing rate based on what the Company would have to pay to borrow on a collateralized basis over the lease
term for an amount equal to the remaining lease payments, taking into consideration such assumptions as, but not limited to, the U.S.
treasury yield rate and borrowing rates from a creditworthy financial institution using the above lease factors.
The lease for the Company’s
corporate headquarters represents all of our significant lease obligations. The amounts reported in the condensed consolidated balance
sheets for the operating lease in which the Company is the lessee and other supplemental balance sheet information is set forth as follows,
in thousands, except the lease term (number of years) and discount rate:
Schedule of lease and supplemental balance sheet information | |
| | |
| |
| |
June 30, 2023 | | |
December 31, 2022 | |
Assets | |
| | | |
| | |
Right of use asset | |
$ | 98 | | |
$ | 161 | |
Liabilities | |
| | | |
| | |
Lease liability, current | |
| 104 | | |
| 135 | |
Lease liability, non-current | |
| – | | |
| 35 | |
Total lease liability | |
$ | 104 | | |
$ | 170 | |
Lease Term and Discount Rate | |
| | | |
| | |
Weighted average remaining lease term | |
| 0.75 | | |
| 1.25 | |
Weighted average discount rate | |
| 4.70% | | |
| 4.70% | |
Operating lease costs included
in operating expense were $33,000 for the
three months ended June 30, 2023 and 2022. Operating lease costs included in operating expense were $66,000
for the six months ended June 30, 2023 and 2022.
Cash paid for the amounts
included in the measurement of the operating lease liability on the Company’s condensed consolidated balance sheets and included
within changes in the lease liability in the operating activities of the Company’s condensed consolidated statements of cash flows
was $35,000 and $34,000 for the three months ended June 30, 2023 and 2022, respectively. Cash paid for
the amounts included in the measurement of the operating lease liability on the Company’s condensed consolidated balance sheets
and included within changes in the lease liability in the operating activities of the Company’s condensed consolidated statements
of cash flow was $69,000 and $67,000 for the six months ended June 30, 2023 and 2022, respectively.
Future lease payments for
the Company’s non-cancellable operating lease and a reconciliation to the carrying amount of the operating lease liability presented
in the condensed consolidated balance sheet as of June 30, 2023 is as follows, in thousands:
Schedule of future minimum lease payments | |
| |
2023 (remaining) | |
$ | 71 | |
2024 | |
| 35 | |
Total lease payments | |
| 106 | |
Less: Imputed interest | |
| (2 | ) |
Total operating lease liability | |
$ | 104 | |
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- DefinitionThe entire disclosure for operating leases of lessee. Includes, but is not limited to, description of operating lease and maturity analysis of operating lease liability.
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v3.23.2
Preferred Stock
|
6 Months Ended |
Jun. 30, 2023 |
Temporary Equity Disclosure [Abstract] |
|
Preferred Stock |
5. Preferred Stock
The Company has
authorized up to 10,000,000 shares of preferred stock, $0.0001 par value per share, for issuance. The Company’s Board of
Directors (the “Board’) is authorized under the Company’s Amended and Restated Articles of Incorporation
(as may be amended and/or restated from time to time, the “Amended Certificate”), to designate the authorized
preferred stock into one or more series and to fix and determine such rights, preferences, privileges and restrictions of any series
of preferred stock, including voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences,
as shall be determined by the Board upon its issuance.
On November 16, 2022,
the Company issued and sold one share of the Company’s Series D Preferred Stock, par value $0.0001 per
share (the “Series D Preferred Stock”) to Robert Bitterman, then its interim Executive Chairman and current Chief
Executive Officer, for $1,750.
The Series D Preferred Stock was entitled to 17,500,000 votes per share exclusively with respect to any proposal to amend the
Company’s Amended Certificate to effect a reverse stock split of the Company’s common stock (“Reverse Stock
Split”). The terms of the Series D Preferred Stock provided that it would be voted, without action by the holder, on any
such proposal in the same proportion as shares of the Company’s common stock were voted. The Series D Preferred Stock
otherwise had no voting rights except as required by the General Corporation Law of the State of Delaware.
The Series D Preferred Stock
was not convertible into, or exchangeable for, shares of any other class or series of stock or other securities of the Company. The Series
D Preferred Stock had no rights with respect to any distribution of assets of the Company, including upon a liquidation, bankruptcy, reorganization,
merger, acquisition, sale, dissolution or winding up of the Company, whether voluntarily or involuntarily. The holder of the Series D
Preferred Stock was not entitled to receive dividends of any kind.
Under its terms, the outstanding
share of Series D Preferred Stock was to be redeemed in whole, but not in part, at any time: (i) if such redemption was approved by the
Board in its sole discretion or (ii) automatically and effective upon the approval by the Company's stockholders of a Reverse Stock Split.
Upon such redemption, the holder of the Series D Preferred Stock was entitled to receive consideration of $1,750 in cash.
The Series D Preferred Stock
was redeemed in whole on January 4, 2023, upon the approval by the Company’s stockholders of a Reverse Stock Split, such that, at
June 30, 2023, there were no shares of Series D Preferred Stock authorized, issued or outstanding and all of the Company’s authorized
shares of preferred stock were undesignated.
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- DefinitionTabular disclosure of temporary equity. Temporary equity is a security with redemption features that are outside the control of the issuer, is not classified as an asset or liability in conformity with GAAP, and is not mandatorily redeemable. Includes any type of security that is redeemable at a fixed or determinable price or on a fixed or determinable date or dates, is redeemable at the option of the holder, or has conditions for redemption which are not solely within the control of the issuer. If convertible, the issuer does not control the actions or events necessary to issue the maximum number of shares that could be required to be delivered under the conversion option if the holder exercises the option to convert the stock to another class of equity. If the security is a warrant or a rights issue, the warrant or rights issue is considered to be temporary equity if the issuer cannot demonstrate that it would be able to deliver upon the exercise of the option by the holder in all cases. Includes stock with put option held by ESOP and stock redeemable by holder only in the event of a change in control of the issuer.
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v3.23.2
Stockholders’ Equity
|
6 Months Ended |
Jun. 30, 2023 |
Equity [Abstract] |
|
Stockholders’ Equity |
6. Stockholders’ Equity
April 2023
Financing — On April 20, 2023, the Company completed a registered direct offering and a concurrent private placement of a
total of: 353,983
registered shares of the Company’s common stock at a purchase price per share of $5.65,
unregistered five and one-half year term Series A warrants to purchase up to 353,983
shares of common stock at an exercise price of $5.40
per share and unregistered eighteen month term Series B warrants to purchase up to 353,983
shares of common stock at an exercise price of $5.40
per share (collectively, the “April 2023 Financing”). In addition, the Company issued unregistered warrants to
the placement agent, H.C. Wainwright & Co., LLC (“HCW”), in the April 2023 Financing to purchase a total of 26,549
shares of common stock at an exercise price of $7.0625
per share. Net proceeds to the Company from the April 2023 Financing were $1,538,000
after deducting placement agent fees and offering expenses.
In connection with the April
2023 Financing, the Company entered into warrant amendment agreements (the “Warrant Amendment Agreements”) with the
participating investors to amend the exercise price of certain existing warrants to purchase up to an aggregate of 191,619 shares of common
stock that were previously issued in April 2018 through January 2021, such that each of the amended warrants have an exercise price of
$5.40 per share. The Company received $24,000 as consideration in connection with the Warrant Amendment Agreements. The Company assessed
the amendments to the exercise price of the warrants under ASC Topic 815, “Derivatives and Hedging” (“ASC
815”) and determined that the amendment to the exercise price was completed in connection with and contingent on the close of
the April 2023 Financing. The increase in fair value of $293,000 related to the Warrant Amendment Agreements was recognized as an equity
issuance cost and recorded in additional paid in capital per ASC 815.
June 2023
Financing – On June 2, 2023, the Company completed a registered direct offering and a concurrent private placement of a
total of: 233,646
registered shares and 72,000
unregistered shares of the Company’s common stock each at a purchase price per share of $4.28,
unregistered pre-funded warrants to purchase up to an aggregate of 628,935
shares of common stock at a purchase price per share of $4.279
and with an exercise price of $0.001
per share, unregistered five and one-half year term Series A warrants to purchase up to an aggregate of 934,581
shares of common stock at an exercise price of $4.03
per share and unregistered eighteen month term Series B warrants to purchase up to an aggregate of 934,581
shares of common stock at an exercise price of $4.03
per share (collectively, the “June 2023 Financing”). In addition, the Company issued unregistered warrants to the
placement agent, HCW, in the June 2023 Financing to purchase a total of 70,094
shares of common stock at an exercise price of $5.35
per share. Net proceeds to the Company from the June 2023 Financing were $3,510,000
after deducting placement agent fees and offering expenses.
Warrants
The Company first assessed the warrants in the
April 2023 Financing and June 2023 Financing under the FASB ASC Topic 480, “Distinguishing Liabilities from Equity” (“ASC
480”) to determine whether they were within the scope of ASC 480. As there were no instances outside of the Company’s
control that could require cash settlement, the Company’s warrants issued in the April 2023 Financing and June 2023 Financing
were determined to be outside the scope of ASC 480.
The
Company then applied and followed the applicable accounting guidance in the FASB ASC Topic 815, “Derivatives and Hedging.”
Financial instruments are accounted for as either derivative liabilities or equity instruments depending on the specific terms of the
agreement. The warrants issued in the April 2023 Financing and June 2023 Financing did not meet the definition of a derivative instrument
as they are indexed to the Company’s common stock and classified within stockholders’ equity. Based on this determination,
the warrants issued in the April 2023 Financing and June 2023 Financing were classified within stockholders’ equity.
During the six months ended June 30, 2023, shares
of common stock issued related to exercises from the pre-funded warrants issued in the June 2023 Financing totaled 175,000. The Company
realized proceeds of $175 from the exercises of the pre-funded warrants. There were no warrants exercised during the six months ended
June 30, 2022.
The following table summarizes the Company’s
outstanding warrants, all of which are classified as equity instruments, at June 30, 2023:
Summary of outstanding warrants | |
| | |
| |
| |
Number of Shares | | |
Weighted- Average Exercise Price Per Share | |
Outstanding at December 31, 2022 | |
| 545,401 | | |
$ | 54.53 | |
Issued | |
| 3,302,706 | | |
| 4.46 | |
Exercised | |
| (175,000 | ) | |
| 0.001 | |
Expired | |
| (1,837 | ) | |
| 1,245.59 | |
Outstanding at June 30, 2023 | |
| 3,671,270 | | |
$ | 9.09 | |
The Company’s
outstanding warrants expire at various dates between October 2023 and December 2028.
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v3.23.2
Stock-based Compensation
|
6 Months Ended |
Jun. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Stock-based Compensation |
7. Stock-based Compensation
Restricted Stock Units
Restricted stock units (“RSUs”)
are issued under the Company’s 2020 Long-Term Incentive Plan (the “2020 Plan”) or as inducement grants issued
outside of the 2020 Plan to new employees. RSUs are generally subject to graded vesting and the satisfaction of certain service requirements.
Upon vesting, each outstanding RSU will be settled for one share of the Company’s common stock. Employee RSU recipients may elect
to net share settle upon vesting, in which case the Company pays the employee’s income taxes due upon vesting and withholds a number
of shares of equal value. The fair value of the RSUs awarded are based upon the Company’s closing stock price at the grant date
and are expensed over the requisite service period.
The following table summarizes the activity of
the Company’s RSUs for the six months ended June 30, 2023:
Summary of RSU activity | |
| | |
| |
| |
Number of Shares | | |
Weighted- Average Grant Date Fair Value Per Share | |
Unvested units at December 31, 2022 | |
| 47,335 | | |
$ | 15.03 | |
Granted | |
| 43,500 | | |
| 5.24 | |
Vested | |
| (18,080 | ) | |
| 16.96 | |
Forfeited | |
| – | | |
| – | |
Unvested units at June 30, 2023 | |
| 72,755 | | |
$ | 8.70 | |
The weighted-average fair
value of RSUs granted during the six months ended June 30, 2023 and 2022 was $5.24 and $10.32, respectively. There were no RSU grants
during the three months ended June 30, 2023 and 2022.
Stock-based compensation
expense related to RSUs was $94,000
and $205,000
for the three and six months ended June 30, 2023, respectively. Stock-based compensation expense related to RSUs was $82,000
and $261,000
for the three and six months ended June 30, 2022, respectively.
The aggregate fair value of
awards that vested during the six months ended June 30, 2023 and 2022 was $95,000 and $128,000, respectively, which represents the market
value of the Company’s common stock on the date that the RSUs vested.
Stock Options
Stock options are available
to be issued under the 2020 Plan and are generally subject to graded vesting and the satisfaction of certain service requirements. Upon
the exercise of a stock option, the Company issues new shares and delivers them to the recipient. The Company does not expect to net share
settle to satisfy stock option exercises.
The Company used the Black-Scholes
option-pricing model to determine the fair value of all its option grants. The risk-free interest rate used for each grant was based upon
the yield on zero-coupon U.S. Treasury securities with a term similar to the expected life of the related option. The Company’s
expected stock price volatility assumption was based upon the Company’s own implied volatility. The expected life assumption used
for option grants was based upon the simplified method provided for under ASC 718. The dividend yield assumption was based upon the fact
that the Company has never paid cash dividends and presently has no intention of paying cash dividends.
The following table summarizes the activity of
the Company’s stock options for the six months ended June 30, 2023:
Summary of Stock Option Activity |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number
of Shares |
|
|
Weighted-
Average
Exercise
Price
Per Share |
|
|
Aggregate
Intrinsic
Value |
|
Balance at December 31,
2022 |
|
|
177 |
|
|
$ |
35,231.40 |
|
|
|
|
|
Granted |
|
|
– |
|
|
|
– |
|
|
|
|
|
Exercised |
|
|
– |
|
|
|
– |
|
|
|
|
|
Forfeited |
|
|
– |
|
|
|
– |
|
|
|
|
|
Expired |
|
|
(31 |
) |
|
|
118,253.58 |
|
|
|
|
|
Balance at June 30, 2023 |
|
|
146 |
|
|
$ |
17,603.40 |
|
|
$ |
– |
|
Exercisable at June 30, 2023 |
|
|
146 |
|
|
$ |
17,603.40 |
|
|
$ |
– |
|
Stock-based compensation
expense related to stock options for the three and six months ended June 30, 2022 was $1,000
and $8,000,
respectively. As of December 31, 2022, the compensation expense for all unvested stock options had been recognized in the Company’s
results of operations.
Compensation Expense Related to Equity Awards
The following table sets
forth total stock-based compensation expense for the three and six months ended June 30, 2023 and 2022, in thousands:
Schedule of stock based compensation expense | |
|
|
|
|
|
| | |
|
|
|
|
|
| |
| |
Three Months Ended | | |
Six Months Ended | |
| |
June 30, | | |
June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Research and development | |
$ | 49 | | |
$ | 53 | | |
$ | 112 | | |
$ | 109 | |
General and administrative | |
| 45 | | |
| 30 | | |
| 93 | | |
| 160 | |
Total stock-based compensation | |
$ | 94 | | |
$ | 83 | | |
$ | 205 | | |
$ | 269 | |
|
X |
- DefinitionThe entire disclosure for share-based payment arrangement.
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v3.23.2
Net Loss per Common Share
|
6 Months Ended |
Jun. 30, 2023 |
Net loss per common share: |
|
Net Loss per Common Share |
8. Net Loss per Common Share
Basic
net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding. Diluted net loss per
share is computed by dividing the Company’s net loss by the weighted average number of common shares outstanding and the impact
of the dilutive effect of potential common stock equivalents, except when the inclusion of such potential common stock equivalents would
be anti-dilutive. Dilutive potential common stock equivalents primarily consist of stock options, RSUs and warrants. Therefore, basic
and diluted net loss per share applicable to common stockholders were the same for all periods presented because the impact of these items
is generally anti-dilutive during periods of net loss.
The weighted average number
of common shares outstanding as of June 30, 2023 includes the pre-funded warrants issued in connection with the June 2023 Financing, the
exercise of which requires nominal consideration for the delivery of the shares of common stock.
The following table sets forth
the potential common shares excluded from the calculation of net loss per common share because their inclusion would be anti-dilutive:
Schedule of anti-dilutive stock |
|
|
|
|
|
|
|
|
June 30, |
|
|
|
2023 |
|
|
2022 |
|
Stock options |
|
|
146 |
|
|
|
175 |
|
Unvested restricted stock units |
|
|
72,755 |
|
|
|
57,248 |
|
Warrants1 |
|
|
3,217,335 |
|
|
|
545,401 |
|
Total |
|
|
3,290,236 |
|
|
|
602,824 |
|
1 The weighted average number of common shares outstanding
as of June 30, 2023 includes the pre-funded warrants issued in the June 2023 Financing because the exercise of such warrants requires
only nominal consideration. Therefore, these pre-funded warrants are not included in the table above.
|
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v3.23.2
Organization and Significant Accounting Policies (Policies)
|
6 Months Ended |
Jun. 30, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Nature of Operations |
Nature of Operations
Phio Pharmaceuticals Corp. (“Phio”
or the “Company”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology
platform is designed to make immune cells more effective in killing tumor cells. Phio is developing therapeutics that are designed to
leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized
formulations or drug delivery systems.
Effective January 26, 2023, the Company completed
a 1-for-12 reverse stock split of the Company’s outstanding common stock, including reclassifying an amount equal to the reduction
in par value to additional paid-in capital. The reverse stock split did not reduce the number of authorized shares of the Company’s
common or preferred stock. All share and per share amounts have been adjusted to give effect to the reverse stock split.
|
Principles of Consolidation |
Principles of Consolidation
The condensed consolidated
financial statements include the accounts of Phio and its wholly-owned subsidiary, MirImmune, LLC. All material intercompany accounts
have been eliminated in consolidation.
|
Basis of Presentation |
Basis of Presentation
The accompanying condensed consolidated financial statements are unaudited
and have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”). Certain
information and footnote disclosures that are included in the Company’s annual consolidated financial statements, but that are not
required for interim reporting purposes, have been condensed or omitted. Additionally, the Company made adjustments to the outstanding
stock option and unvested restricted stock unit balances, and related per share amounts, at December 31, 2022 to reflect final revisions
to these outstanding equity awards as a result of the Company’s reverse stock split. The adjustment had no effect on the Company’s
condensed consolidated financial statements. These statements should be read in conjunction with the audited consolidated financial statements
and notes thereto included in the Company’s most recent Annual Report on Form 10-K for the year ended December 31, 2022, as filed
with the Securities and Exchange Commission (the “SEC”) on March 22, 2023 (the “2022 Form 10-K”).
In the opinion of management, all adjustments (including normal recurring accruals) considered necessary for a fair presentation of the
condensed consolidated financial statements have been included. Interim results are not necessarily indicative of results for a full year.
|
Use of Estimates |
Use of Estimates
The preparation of financial
statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and
liabilities and disclosure of contingent assets and liabilities as of the date of the financial statements and the reported amounts of
revenues and expenses during the reporting period. The areas subject to significant estimates and judgement include, among others, those
related to the fair value of equity awards, accruals for research and development expenses, useful lives of property and equipment, income
taxes, and the valuation allowance on the Company’s deferred tax assets. On an ongoing basis the Company evaluates its estimates
and bases its estimates on historical experience and other relevant assumptions that the Company believes are reasonable under the circumstances.
Actual results could differ materially from these estimates.
|
Liquidity |
Liquidity
The Company has reported recurring
losses from operations since inception and expects to continue to have negative cash flows from operations for the foreseeable future.
Historically, the Company’s primary source of funding has been from sales of its securities. The Company’s ability to continue
to fund its operations is dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity,
or strategic opportunities, in order to maintain its operations. This is dependent on a number of factors, including the market demand
or liquidity of the Company’s common stock. There is no guarantee that debt, additional equity or other funding will be available
to the Company on acceptable terms, or at all. If the Company fails to obtain additional funding when needed, the Company would be forced
to scale back or terminate its operations or seek to merge with or to be acquired by another company.
The Company has limited cash
resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise
substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources
may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial
statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through
an equity offering, debt offering and/or strategic opportunity to fund its operations. There can be no assurance that the Company will
be successful in accomplishing these plans in order to continue as a going concern. These financial statements do not include any adjustments
to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the
Company be unable to continue as a going concern.
|
Summary of Significant Accounting Policies |
Summary of Significant Accounting Policies
There have been no material
changes to the significant accounting policies disclosed in the Company’s 2022 Form 10-K.
|
Recent Accounting Pronouncements |
Recent Accounting Pronouncements
There have been no recent
accounting pronouncements that have significantly impacted this Quarterly Report on Form 10-Q, beyond those disclosed in the Company’s
2022 Form 10-K.
|
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v3.23.2
Leases (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Leases [Abstract] |
|
Schedule of lease and supplemental balance sheet information |
Schedule of lease and supplemental balance sheet information | |
| | |
| |
| |
June 30, 2023 | | |
December 31, 2022 | |
Assets | |
| | | |
| | |
Right of use asset | |
$ | 98 | | |
$ | 161 | |
Liabilities | |
| | | |
| | |
Lease liability, current | |
| 104 | | |
| 135 | |
Lease liability, non-current | |
| – | | |
| 35 | |
Total lease liability | |
$ | 104 | | |
$ | 170 | |
Lease Term and Discount Rate | |
| | | |
| | |
Weighted average remaining lease term | |
| 0.75 | | |
| 1.25 | |
Weighted average discount rate | |
| 4.70% | | |
| 4.70% | |
|
Schedule of future minimum lease payments |
Schedule of future minimum lease payments | |
| |
2023 (remaining) | |
$ | 71 | |
2024 | |
| 35 | |
Total lease payments | |
| 106 | |
Less: Imputed interest | |
| (2 | ) |
Total operating lease liability | |
$ | 104 | |
|
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v3.23.2
Stockholders’ Equity (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Equity [Abstract] |
|
Summary of outstanding warrants |
Summary of outstanding warrants | |
| | |
| |
| |
Number of Shares | | |
Weighted- Average Exercise Price Per Share | |
Outstanding at December 31, 2022 | |
| 545,401 | | |
$ | 54.53 | |
Issued | |
| 3,302,706 | | |
| 4.46 | |
Exercised | |
| (175,000 | ) | |
| 0.001 | |
Expired | |
| (1,837 | ) | |
| 1,245.59 | |
Outstanding at June 30, 2023 | |
| 3,671,270 | | |
$ | 9.09 | |
|
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v3.23.2
Stock-based Compensation (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Summary of RSU activity |
Summary of RSU activity | |
| | |
| |
| |
Number of Shares | | |
Weighted- Average Grant Date Fair Value Per Share | |
Unvested units at December 31, 2022 | |
| 47,335 | | |
$ | 15.03 | |
Granted | |
| 43,500 | | |
| 5.24 | |
Vested | |
| (18,080 | ) | |
| 16.96 | |
Forfeited | |
| – | | |
| – | |
Unvested units at June 30, 2023 | |
| 72,755 | | |
$ | 8.70 | |
|
Summary of Stock Option Activity |
Summary of Stock Option Activity |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number
of Shares |
|
|
Weighted-
Average
Exercise
Price
Per Share |
|
|
Aggregate
Intrinsic
Value |
|
Balance at December 31,
2022 |
|
|
177 |
|
|
$ |
35,231.40 |
|
|
|
|
|
Granted |
|
|
– |
|
|
|
– |
|
|
|
|
|
Exercised |
|
|
– |
|
|
|
– |
|
|
|
|
|
Forfeited |
|
|
– |
|
|
|
– |
|
|
|
|
|
Expired |
|
|
(31 |
) |
|
|
118,253.58 |
|
|
|
|
|
Balance at June 30, 2023 |
|
|
146 |
|
|
$ |
17,603.40 |
|
|
$ |
– |
|
Exercisable at June 30, 2023 |
|
|
146 |
|
|
$ |
17,603.40 |
|
|
$ |
– |
|
|
Schedule of stock based compensation expense |
Schedule of stock based compensation expense | |
|
|
|
|
|
| | |
|
|
|
|
|
| |
| |
Three Months Ended | | |
Six Months Ended | |
| |
June 30, | | |
June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Research and development | |
$ | 49 | | |
$ | 53 | | |
$ | 112 | | |
$ | 109 | |
General and administrative | |
| 45 | | |
| 30 | | |
| 93 | | |
| 160 | |
Total stock-based compensation | |
$ | 94 | | |
$ | 83 | | |
$ | 205 | | |
$ | 269 | |
|
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v3.23.2
Net Loss per Common Share (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Net loss per common share: |
|
Schedule of anti-dilutive stock |
Schedule of anti-dilutive stock |
|
|
|
|
|
|
|
|
June 30, |
|
|
|
2023 |
|
|
2022 |
|
Stock options |
|
|
146 |
|
|
|
175 |
|
Unvested restricted stock units |
|
|
72,755 |
|
|
|
57,248 |
|
Warrants1 |
|
|
3,217,335 |
|
|
|
545,401 |
|
Total |
|
|
3,290,236 |
|
|
|
602,824 |
|
|
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v3.23.2
Collaboration Agreement (Details Narrative) - Clinical Co-Development Agreement [Member] - USD ($)
|
3 Months Ended |
6 Months Ended |
|
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Mar. 31, 2021 |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
|
|
|
|
|
Contractual obligation |
$ 3,570,000
|
|
$ 3,570,000
|
|
$ 4,000,000
|
Expense from contractual obligations |
$ 181,000
|
$ 0
|
$ 300,000
|
$ 0
|
|
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- DefinitionFair value portion of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.
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v3.23.2
Leases (Details Narrative)
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2023
USD ($)
ft²
|
Jun. 30, 2022
USD ($)
|
Jun. 30, 2023
USD ($)
ft²
|
Jun. 30, 2022
USD ($)
|
Operating Lease, Cost |
$ 33,000
|
$ 33,000
|
$ 66,000
|
$ 66,000
|
Operating Lease, Payments |
$ 35,000
|
$ 34,000
|
$ 69,000
|
$ 67,000
|
Property Subject to Operating Lease [Member] |
|
|
|
|
Operating lease footage | ft² |
7,581
|
|
7,581
|
|
Lease Expiration Date |
|
|
Mar. 31, 2024
|
|
X |
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v3.23.2
Preferred Stock (Details Narrative) - USD ($)
|
|
1 Months Ended |
|
Nov. 16, 2022 |
Nov. 16, 2022 |
Jun. 30, 2023 |
Temporary Equity [Line Items] |
|
|
|
Preferred stock, shares authorized |
|
|
10,000,000
|
Preferred stock, par value |
|
|
$ 0.0001
|
Series D Preferred Stock [Member] |
|
|
|
Temporary Equity [Line Items] |
|
|
|
Temporary Equity, Aggregate Amount of Redemption Requirement |
|
|
$ 1,750
|
Series D Preferred Stock [Member] | Robert Bitterman [Member] |
|
|
|
Temporary Equity [Line Items] |
|
|
|
Issuance of preferred stock, shares |
1
|
|
|
Temporary Equity, Stock Issued During Period, Value, New Issues |
|
$ 1,750
|
|
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v3.23.2
Stockholders' Equity (Details - Warrants outstanding) - Warrant [Member]
|
6 Months Ended |
Jun. 30, 2023
$ / shares
shares
|
Class of Warrant or Right [Line Items] |
|
Warrants outstanding | shares |
545,401
|
Warrants outstanding, weighted average exercise price | $ / shares |
$ 54.53
|
Warrants issued, shares | shares |
3,302,706
|
Warrants issued, weighted average exercise price | $ / shares |
$ 4.46
|
Warrants exercised, shares | shares |
(175,000)
|
Warrants exercised, weighted average exercise price | $ / shares |
$ 0.001
|
Warrants expired, shares | shares |
(1,837)
|
Warrants expired, weighted average exercise price | $ / shares |
$ 1,245.59
|
Warrants outstanding | shares |
3,671,270
|
Warrants outstanding, weighted average exercise price | $ / shares |
$ 9.09
|
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v3.23.2
Stockholders’ Equity (Details Narrative) - USD ($)
|
1 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Apr. 30, 2023 |
Jun. 30, 2023 |
April 2023 Financing [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Stock Issued During Period, Shares, New Issues |
|
353,983
|
|
Shares Issued, Price Per Share |
|
$ 5.65
|
|
Proceeds from Issuance or Sale of Equity |
|
$ 1,538,000
|
|
April 2023 Financing [Member] | Warrant Amendment Agreements [Member] | Previously Issued Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Class of Warrant or Right, Exercise Price of Warrants or Rights |
|
$ 5.40
|
|
[custom:AmendedWarrants] |
|
191,619
|
|
Proceeds from amendment of warrants |
|
$ 24,000
|
|
Equity-Classified Written Call Option, Modification, Equity Issuance, Increase (Decrease) in Equity, Amount |
|
$ 293,000
|
|
April 2023 Financing [Member] | Series A Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Warrants Issued New Shares |
|
353,983
|
|
Class of Warrant or Right, Exercise Price of Warrants or Rights |
|
$ 5.40
|
|
April 2023 Financing [Member] | Series B Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Warrants Issued New Shares |
|
353,983
|
|
Class of Warrant or Right, Exercise Price of Warrants or Rights |
|
$ 5.40
|
|
April 2023 Financing [Member] | Placement Agent Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Warrants Issued New Shares |
|
26,549
|
|
Class of Warrant or Right, Exercise Price of Warrants or Rights |
|
$ 7.0625
|
|
June 2023 Financing [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Shares Issued, Price Per Share |
$ 4.28
|
|
$ 4.28
|
Proceeds from Issuance or Sale of Equity |
$ 3,510,000
|
|
|
June 2023 Financing [Member] | Series A Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Warrants Issued New Shares |
934,581
|
|
934,581
|
Class of Warrant or Right, Exercise Price of Warrants or Rights |
$ 4.03
|
|
$ 4.03
|
June 2023 Financing [Member] | Series B Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Warrants Issued New Shares |
934,581
|
|
934,581
|
Class of Warrant or Right, Exercise Price of Warrants or Rights |
$ 4.03
|
|
$ 4.03
|
June 2023 Financing [Member] | Placement Agent Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Warrants Issued New Shares |
70,094
|
|
70,094
|
Class of Warrant or Right, Exercise Price of Warrants or Rights |
$ 5.35
|
|
$ 5.35
|
June 2023 Financing [Member] | Registered Shares [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Stock Issued During Period, Shares, New Issues |
233,646
|
|
|
June 2023 Financing [Member] | Unregistered Shares [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Stock Issued During Period, Shares, New Issues |
72,000
|
|
|
June 2023 Financing [Member] | Unregistered Pre Funded Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Shares Issued, Price Per Share |
$ 4.279
|
|
$ 4.279
|
Warrants Issued New Shares |
628,935
|
|
628,935
|
Class of Warrant or Right, Exercise Price of Warrants or Rights |
$ 0.001
|
|
$ 0.001
|
June 2023 Financing [Member] | June 2023 Pre Funded Warrants [Member] |
|
|
|
Class of Stock [Line Items] |
|
|
|
Stock issued from conversion of warrants, shares |
|
|
175,000
|
Proceeds from Warrant Exercises |
|
|
$ 175
|
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v3.23.2
Stock-based Compensation (Details - RSU activity) - Restricted Stock Units (RSUs) [Member] - $ / shares
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
RSU's unvested units, beginning balance |
|
|
47,335
|
|
RSU beginning balance, price per share |
|
|
$ 15.03
|
|
RSU's granted |
0
|
0
|
43,500
|
|
RSU's granted, price per share |
|
|
$ 5.24
|
$ 10.32
|
RSU's vested |
|
|
(18,080)
|
|
RSU's vested, price per share |
|
|
$ 16.96
|
|
RSU's forfeited |
|
|
0
|
|
RSU's forfeited, price per share |
|
|
$ 0
|
|
RSU's unvested units, ending balance |
72,755
|
|
72,755
|
|
RSU ending balance, price per share |
$ 8.70
|
|
$ 8.70
|
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- DefinitionThe number of equity-based payment instruments, excluding stock (or unit) options, that were forfeited during the reporting period.
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v3.23.2
Stock-based Compensation (Details - Option activity) - Share-Based Payment Arrangement, Option [Member] $ / shares in Units, $ in Thousands |
6 Months Ended |
Jun. 30, 2023
USD ($)
$ / shares
shares
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
Options outstanding, beginning balance | shares |
177
|
Options outstanding, price per share, beginning balance | $ / shares |
$ 35,231.40
|
Options granted | shares |
0
|
Options granted, price per share | $ / shares |
$ 0
|
Options exercised | shares |
0
|
Options exercised, price per share | $ / shares |
$ 0
|
Options forfeited | shares |
0
|
Options forfeited, price per share | $ / shares |
|
Options expired | shares |
(31)
|
Options expired, price per share | $ / shares |
$ 118,253.58
|
Options outstanding, ending balance | shares |
146
|
Options outstanding, price per share, ending balance | $ / shares |
$ 17,603.40
|
Aggregate Intrinsic Value, outstanding | $ |
$ 0
|
Options exercisable | shares |
146
|
Options exercisable, price per share | $ / shares |
$ 17,603.40
|
Aggregate Intrinsic Value, Exercisable | $ |
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|
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Stock-based Compensation (Details - Share-based compensation) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Total stock-based compensation |
$ 94
|
$ 83
|
$ 205
|
$ 269
|
Research and Development Expense [Member] |
|
|
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Total stock-based compensation |
49
|
53
|
112
|
109
|
General and Administrative Expense [Member] |
|
|
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Total stock-based compensation |
$ 45
|
$ 30
|
$ 93
|
$ 160
|
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Stock-based Compensation (Details Narrative) - USD ($)
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
Share-based compensation expense |
$ 94,000
|
$ 83,000
|
$ 205,000
|
$ 269,000
|
Restricted Stock Units (RSUs) [Member] |
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value |
|
|
$ 5.24
|
$ 10.32
|
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period |
0
|
0
|
43,500
|
|
Share-based compensation expense |
$ 94,000
|
$ 82,000
|
$ 205,000
|
$ 261,000
|
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value |
|
|
$ 95,000
|
128,000
|
Share-Based Payment Arrangement, Option [Member] |
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |
|
|
|
|
Share-based compensation expense |
|
$ 1,000
|
|
$ 8,000
|
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v3.23.2
Net Loss per Share (Details - Antidilutive shares) - shares
|
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive shares |
3,290,236
|
602,824
|
Stock Options [Member] |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive shares |
146
|
175
|
Restricted Stock Units (RSUs) [Member] |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive shares |
72,755
|
57,248
|
Warrant [Member] |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Antidilutive shares |
3,217,335
|
545,401
|
X |
- DefinitionSecurities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.
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