UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 6-K
REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO
RULE 13a-16 OR 15d-16
UNDER THE SECURITIES EXCHANGE ACT OF 1934
For the month of April 2024
Commission File Number: 001-39458
Medicenna Therapeutics Corp.
(Translation of registrant’s name into
English)
2 Bloor St. W. 7th Floor
Toronto, Ontario M4W 3E2
Canada
(Address of principal executive office)
Indicate by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F.
SIGNATURES
Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
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Medicenna Therapeutics Corp. |
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(Registrant) |
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| Date: April 30, 2024 |
By: |
/s/ Fahar Merchant |
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Name: |
Fahar Merchant, PhD |
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Title: |
Chief Executive Officer |
Form 6-K Exhibit Index
Exhibit 99.1
Medicenna Therapeutics
Announces Closing of CA$20 Million Investment from RA Capital Management
Not for
distribution to United States news wire services or for dissemination in the United States
TORONTO and HOUSTON,
April 30, 2024 – Medicenna Therapeutics Corp. (“Medicenna” or the “Company”) (TSX:
MDNA) (MDNAF: OTCQB), a clinical-stage immunotherapy company focused on the development of engineered cytokines, announced today the closing
of its previously announced CA$20 million investment by RA Capital Management, a multi-stage investment manager based in Boston,
MA, by way of a non-brokered private placement (the “Offering”). Medicenna intends to use the net proceeds from the Offering
for further development of its MDNA11 program, advancement of its preclinical programs and general corporate purposes.
Pursuant to the terms
of a subscription agreement entered into as of April 26, 2024 between the Company and RA Capital Healthcare Fund, L.P. (“RAHF”),
a fund affiliated with RA Capital Management, RAHF subscribed for 5,141,388 common shares in the capital of the Company (the “Shares”)
at a price of CA$1.95 per share and, in lieu of common shares, pre-funded warrants to purchase 5,141,388 common shares (the “Pre-Funded
Warrants”) at a purchase price of CA$1.94 per pre-funded warrant, for total net proceeds to the Company of approximately CA$20 million.
The Shares and Pre-Funded
Warrants have not been and will not be registered under the United States Securities Act of 1933, as amended (the “U.S. Securities
Act”), or any U.S. state securities laws and may not be offered or sold within the “United States” or to “U.S.
Persons” (as such terms are defined in Regulation S under the U.S. Securities Act) unless registered under the U.S. Securities Act
and applicable state securities laws or pursuant to an applicable exemption from such registration is available.
This news release shall
not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities
in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification
under the securities laws of any such state or other jurisdiction.
About Medicenna
Medicenna is a clinical-stage
immunotherapy company focused on developing novel, highly selective versions of IL-2, IL-4 and IL-13 Superkines and first-in-class empowered
superkines. Medicenna’s long-acting IL-2 Superkine, MDNA11, is a next-generation IL-2 with superior affinity toward CD122 (IL-2
receptor beta) and no CD25 (IL-2 receptor alpha) binding, thereby preferentially stimulating cancer-killing effector T cells and NK cells.
Medicenna’s IL-4 Empowered Superkine, bizaxofusp (formerly MDNA55), has been studied in 5 clinical trials enrolling over 130 patients,
including a Phase 2b trial for recurrent GBM, the most common and uniformly fatal form of brain cancer. Bizaxofusp has obtained FastTrack
and Orphan Drug status from the FDA and FDA/EMA, respectively. Medicenna’s early-stage BiSKITs™ (Bifunctional SuperKine ImmunoTherapies)
and the T-MASK™ (Targeted Metalloprotease Activated SuperKine) programs are designed to enhance the ability of Superkines to treat
immunologically “cold” tumors.
For more information,
please visit www.medicenna.com, and follow us on Twitter and LinkedIn.
Forward-Looking
Statements
This news release contains
forward-looking statements within the meaning of applicable securities laws. All statements in this news release, other than statements
of historical facts, that address events or developments that the Company expects to occur are forward-looking statements, including,
but are not limited to, statements relating to the Offering and the terms thereof, and the proposed use of proceeds from the Offering.
Forward-looking statements also include express or implied statements regarding the future operations of the Company, estimates, plans,
strategic ambitions, partnership activities and opportunities, objectives, expectations, opinions, forecasts, projections, guidance, outlook
or other statements that are not historical facts, such as statements on the Company’s cash runway, preclinical and clinical development
activities, clinical trial designs, clinical potential, expectations and beliefs around safety profiles and upcoming milestones and data
reporting, including with respect to MDNA11, the ABILITY study and its expansion, bizaxofusp (MDNA55), MDNA113 and MDNA223. Drug development
and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization
of a product. Results in early-stage clinical studies may not be indicative of full results or results from later stage or larger scale
clinical studies and do not ensure regulatory approval. You should not place undue reliance on these statements or the scientific data
presented. Forward-looking statements are often identified by terms such as “will”, “may”, “should”,
“anticipate”, “expect”, “believe”, “seek”, “potentially” and similar expressions.
Forward-looking statements are based on a number of assumptions believed by the Company to be reasonable at the date of this news release.
Although the Company believes that the expectations reflected in such forward-looking statements are reasonable, there can be no assurance
that such statements will prove to be accurate. These statements are subject to certain risks and uncertainties and may be based on assumptions
that could cause actual results and future events to differ materially from those anticipated or implied in such statements. Important
factors that could cause actual results to differ materially from the Company’s expectations include the risks detailed in the latest
Annual Report on Form 20-F of the Company and in other filings made by the Company with the applicable securities regulators from time
to time in Canada.
The reader is cautioned
that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause
actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors,
many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information.
Such information, although considered reasonable by management, may prove to be incorrect and actual results may differ materially from
those anticipated or implied in forward-looking statements. Forward-looking statements contained in this news release are expressly qualified
by this cautionary statement. The forward-looking statements contained in this news release are made as of the date hereof and except
as required by law, we do not intend and do not assume any obligation to update or revise publicly any of the included forward-looking
statements.
This news release contains
hyperlinks to information that is not deemed to be incorporated by reference in this news release.
Investor and Media Contact:
Christina Cameron
Investor Relations, Medicenna Therapeutics
ir@medicenna.com
(647) 953-0673
Exhibit 99.2
FORM 51-102F3
MATERIAL CHANGE REPORT
| 1. | Name and Address of Company |
Medicenna Therapeutics Corp. (the “Company”)
2 Bloor Street West, 7th Floor
Toronto, Ontario M4W 3E2
| 2. | Date of Material Changes |
April 26, 2024
A news release with respect to the
material change referred to in this report was issued by the Company through the services of Globe Newswire on April 26, 2024, and
subsequently filed on the System for Electronic Data Analysis and Retrieval + (SEDAR+) at www.sedarplus.ca.
| 4. | Summary of Material Change |
On April 26, 2024, the Company
announced a CA$20 million investment by RA Capital Management, a multi-stage investment manager based in Boston, MA, by way of a
non-brokered private placement (the “Offering”).
Pursuant to the terms of a subscription
agreement entered into as of April 26, 2024 between the Company and RA Capital Healthcare Fund, L.P. (“RAHF”), a fund
affiliated with RA Capital Management, RAHF subscribed, on April 30, 2024, for 5,141,388 common shares in the capital of the Company
(the “Shares”) at a price of CA$1.95 and, in lieu of common shares, pre-funded warrants to purchase 5,141,388 common
shares (the “Pre-Funded Warrants”) at a purchase price of CA$1.94 per Pre-Funded Warrant for net proceeds to
the Company of approximately CA$20 million.
The Company intends to use the net proceeds
from the Offering for further development of its MDNA11 program, advancement of its preclinical programs and general corporate purposes.
| 5. | Full Description of Material Change |
5.1 Full
Description of Material Change
On April 26, 2024, the Company
announced the Offering.
Pursuant to the Offering, RAHF subscribed,
on April 30, 2024, for 5,141,388 Shares at a price of CA$1.95 per Share and Pre-Funded Warrants to purchase 5,141,388 common
shares at a purchase price of CA$1.94 per Pre-Funded Warrant for net proceeds to the Company of approximately CA$20 million.
The Pre-Funded Warrants entitle RAHF to subscribe to common
shares in the capital of the Company (the “Pre-Funded Shares”) at a price of CA$0.01 per Pre-Funded Warrant Share
at any time until the Pre-Funded Warrants are exercised in full. A copy of the Pre-Funded Warrant certificate has been filed under the
Company’s profile on SEDAR+.
The Company intends to use the net proceeds
from the Offering for further development of its MDNA11 program, advancement of its preclinical programs and general corporate purposes.
5.2 Forward-Looking
Statements
This material change report contains
forward-looking statements within the meaning of applicable securities laws. All statements in this material change report, other than
statements of historical facts, that address events or developments that the Company expects to occur, are forward-looking statements,
including, but are not limited to, statements relating to the Offering and the terms thereof, and the proposed use of proceeds from the
Offering. Forward-looking statements also include express or implied statements regarding the future operations of the Company, estimates,
plans, strategic ambitions, partnership activities and opportunities, objectives, expectations, opinions, forecasts, projections, guidance,
outlook or other statements that are not historical facts, such as statements on the Company’s cash runway, preclinical and clinical
development activities, clinical trial designs, clinical potential, expectations and beliefs around safety profiles and upcoming milestones
and data reporting, including with respect to MDNA11, the ABILITY study and its expansion, bizaxofusp (MDNA55), MDNA113 and MDNA223. Drug
development and commercialization involve a high degree of risk, and only a small number of research and development programs result in
commercialization of a product. Results in early-stage clinical studies may not be indicative of full results or results from later stage
or larger scale clinical studies and do not ensure regulatory approval. You should not place undue reliance on these statements or the
scientific data presented. Forward-looking statements are often identified by terms such as “will”, “may”, “should”,
“anticipate”, “expect”, “believe”, “seek”, “potentially” and similar expressions.
Forward-looking statements are based on a number of assumptions believed by the Company to be reasonable at the date of this material
change report. Although the Company believes that the expectations reflected in such forward-looking statements are reasonable, there
can be no assurance that such statements will prove to be accurate. These statements are subject to certain risks and uncertainties and
may be based on assumptions that could cause actual results and future events to differ materially from those anticipated or implied in
such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include
the risks detailed in the latest Annual Report on Form 20-F of the Company and in other filings made by the Company with the applicable
securities regulators from time to time in Canada.
The reader is cautioned that assumptions
used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results
to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of
which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such
information, although considered reasonable by management, may prove to be incorrect and actual results may differ materially from those
anticipated or implied in forward-looking statements. Forward-looking statements contained in this material change report are expressly
qualified by this cautionary statement. The forward-looking statements contained in this material change report are made as of the date
hereof and except as required by law, we do not intend and do not assume any obligation to update or revise publicly any of the included
forward-looking statements.
| 6. | Reliance on Section 7.1(2) of National Instrument 51-102 |
Not applicable.
Not applicable
For additional information with respect
to the material change referred to herein, the following person may be contacted:
David Hyman
Chief Financial Officer
(403) 613-1453
dhyman@medicenna.com
April 30, 2024
Exhibit 99.3
PRE-FUNDED
COMMON SHARE PURCHASE WARRANT
Medicenna Therapeutics Corp.
Warrant
Certificate No.: 2024-PFW-01
Number of Common Shares Purchasable: 5,141,388 |
Date:
April 30, 2024 |
THIS PRE-FUNDED COMMON SHARE
PURCHASE WARRANT CERTIFICATE (the “Pre-Funded Warrant”) certifies that, for value received, RA Capital Healthcare
Fund, L.P. (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions
hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) and until this Pre-Funded
Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from
Medicenna Therapeutics Corp. (the “Corporation”), up to 5,141,388 Common Shares (as defined below) (as subject
to adjustment hereunder, the “Warrant Shares”). The purchase price of one Common Share under this Pre-Funded Warrant
shall be equal to the Exercise Price, as defined in Section 2.b).
Section 1. Definitions.
In addition to the terms defined elsewhere in this Pre-Funded Warrant, the following terms have the meanings indicated in this Section 1:
“CA$”
or “dollars” means lawful money of Canada.
“Business Day”
means any day except any Saturday, any Sunday, any day which is a statutory holiday in the City of Toronto, Ontario, Canada.
“Common Shares”
means the common shares in the share capital of the Corporation, and any other class of securities into which such securities may hereafter
be reclassified or changed.
“Common Share Equivalents”
means any securities of the Corporation or the Subsidiaries which would entitle the holder thereof to acquire at any time Common Shares,
including, without limitation, any debt, preferred shares, right, option, warrant or other instrument that is at any time convertible
into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Shares.
“Exchange Act”
means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.
“Offering”
means the issue and sale of Common Shares and Pre-Funded Warrants to the holder by the Corporation completed on April 30, 2024.
“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.
“Principal Trading
Market” means the TSX or, if the Common Shares are traded on a Trading Market in the United States and the Holder is a resident
of the United States, the Trading Market in the United States where the Common Shares are traded.
“Subsidiary”
means any subsidiary of the Corporation and shall, where applicable, also include any direct or indirect subsidiary of the Corporation
formed or acquired after the date hereof.
“Trading Day”
means a day on which the Common Shares may be traded on a Trading Market.
“Trading Market”
means any of the following markets or exchanges on which the Common Shares are listed or quoted for trading on the date in question:
the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange,
the TSX, the TSX Venture Exchange, the NEO Exchange (or any successors to any of the foregoing).
“Transfer Agent”
means TSX Trust Company, the current transfer agent of the Corporation, and any successor transfer agent of the Corporation.
“TSX”
means Toronto Stock Exchange.
“VWAP”
means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common Shares are then
listed or quoted on a Trading Market in Canada, the volume weighted average price of the Common Shares on such Trading Market, (b) the
volume weighted average price of the Common Shares on the over-the-counter market on OTCQB or OTCQX as applicable, (c) if the Common
Shares are not then listed or quoted for trading on OTCQB or OTCQX and if prices for the Common Shares are then reported in the “Pink
Sheets” published by OTC Markets Group, Inc. (or a similar organization or agency succeeding to its functions of reporting
prices), the most recent bid price per share of the Common Shares so reported, or (d) in all other cases, the fair market value
of a Common Share as determined by an independent appraiser selected in good faith by the Corporation and reasonably acceptable to the
Holder, the fees and expenses of which shall be paid by the Corporation.
Section 2. Exercise.
a) Exercise
of Pre-Funded Warrant. Exercise of the purchase rights represented by this Pre-Funded Warrant may be made, in whole or in part, at
any time or times on or after the Initial Exercise Date and on or before the Termination Date by delivery to the Corporation of a duly
executed PDF copy of the Notice of Exercise in the form annexed hereto (the “Notice of Exercise”), submitted
by e-mail to (i) the Chief Financial Officer of the Corporation at dhyman@medicenna.com and to (ii) Charles-Antoine
Soulière at casouliere@mccarthy.ca, together with the aggregate Exercise Price for the shares specified in the applicable
Notice of Exercise by wire transfer. No ink-original Notice of Exercise shall be required, nor shall any medallion guarantee (or other
type of guarantee or notarization) of any Notice of Exercise be required. Notwithstanding anything herein to the contrary, the Holder
shall not be required to physically surrender this Pre-Funded Warrant to the Corporation until the Holder has purchased all of the Warrant
Shares available hereunder and the Pre-Funded Warrant has been exercised in full, in which case, the Holder shall surrender this Pre-Funded
Warrant to the Corporation for cancellation within three (3) Trading Days of the date on which the final Notice of Exercise is delivered
to the Corporation. Partial exercises of this Pre-Funded Warrant resulting in purchases of a portion of the total number of Warrant Shares
available hereunder shall have the effect of lowering the outstanding number of Warrant Shares purchasable hereunder in an amount equal
to the applicable number of Warrant Shares purchased. The Holder and the Corporation shall maintain records showing the number of Warrant
Shares purchased and the date of such purchases. The Corporation shall deliver any objection to any Notice of Exercise within one (1) Business
Day of receipt of such notice or such other shorter period of time in order to allow for the settlement of the Warrant Shares in the
applicable Notice of Exercise by the Warrant Share Delivery Date. The Holder, by acceptance of this Pre-Funded Warrant, acknowledges
and agrees that, by reason of the provisions of this paragraph, following the purchase of a portion of the Warrant Shares hereunder,
the number of Warrant Shares available for purchase hereunder at any given time may be less than the amount stated on the face hereof.
b) Exercise
Price. The aggregate exercise price of this Pre-Funded Warrant, except for a nominal exercise price of CA$0.01 per Warrant Share,
was pre-funded to the Corporation on or prior to the Initial Exercise Date and, consequently, no additional consideration (other than
the nominal exercise price of CA$0.01 per Warrant Share) shall be required to be paid by the Holder to the Corporation to effect any
exercise of this Pre-Funded Warrant. The Holder shall not be entitled to the return or refund of all, or any portion, of such pre-paid
aggregate exercise price under any circumstance or for any reason whatsoever. The remaining unpaid exercise price per Warrant Share under
this Pre-Funded Warrant shall be CA$0.01, subject to adjustment hereunder (the “Exercise Price”).
c) Mechanics
of Exercise.
i. Delivery
of the Warrant Shares Upon Exercise. The Corporation shall cause the Warrant Shares purchased hereunder to be transmitted by the
Transfer Agent to the Holder by either the physical delivery of a certificate, registered in the Corporation’s share register in
the name of the Holder or its qualified designee, or the confirmation of a registration of the Warrant Shares in the name of the Holder
or its designee in Corporation’s records in book-entry form via a direct registration system (DRS) maintained by or on behalf of
the Corporation or otherwise as directed by the Holder, in each case for the number of Warrant Shares to which the Holder is entitled
pursuant to such exercise to the address specified by the Holder in the Notice of Exercise by the earlier of (A) the date that is
two (2) Trading Days after the delivery to the Corporation of (i) the Notice of Exercise and (ii) the aggregate Exercise
Price or (B) the standard settlement period, expressed in a number of Trading Days, for the Principal Trading Market that is in
effect on the date of delivery of an applicable Exercise Notice as is industry practice for regular-way trading on the Principal Trading
Market after the delivery to the Corporation of (i) the Notice of Exercise and (ii) the aggregate Exercise Price (such date,
the “Warrant Share Delivery Date”). Upon delivery of the Notice of Exercise and the aggregate Exercise Price,
the Holder shall be deemed for all corporate purposes to have become the holder of record of the Warrant Shares with respect to which
this Pre-Funded Warrant has been exercised, irrespective of the date of delivery of the Warrant Shares.
ii. Delivery
of New Pre-Funded Warrants Upon Exercise. If this Pre-Funded Warrant shall have been exercised in part, the Corporation shall, at
the request of the Holder and upon surrender of this Pre-Funded Warrant certificate, at the time of delivery of the Warrant Shares, deliver
to the Holder a new Pre-Funded Warrant evidencing the rights of the Holder to purchase the unpurchased Warrant Shares called for by this
Pre-Funded Warrant, which new Pre-Funded Warrant shall in all other respects be identical with this Pre-Funded Warrant.
iii. Rescission
Rights. If the Corporation fails to transmit to the Holder the Warrant Shares pursuant to Section 2.c) by the Warrant Share
Delivery Date, then the Holder will have the right to rescind such exercise.
iv. Failure
to Deliver Warrant Shares. In addition to any other rights available to the Holder, if the Corporation fails to deliver to the Holder
or its designee the applicable Warrant Shares in the manner required pursuant to Section 2.c) by the Warrant Share Delivery Date
following the Notice of Exercise date and the Holder purchases (in an open market transaction or otherwise) Common Shares to deliver
in satisfaction of a sale by the Holder of the Warrant Shares which the Holder anticipated receiving upon such exercise (a “Buy-In”)
but did not receive by the Warrant Share Delivery Date, then the Corporation shall, within two (2) Trading Days after the Holder’s
request and in the Holder’s sole discretion, promptly honor its obligation to deliver to the Holder or its designee the Warrant
Shares pursuant to Section 2.c) and pay cash to the Holder in an amount equal to the excess (if any) of Holder’s total purchase
price (including brokerage commissions, if any) for the Common Shares so purchased in the Buy-In, less the product of (A) the Common
Shares purchased in the Buy-In, times (B) the closing price of the Common Shares on the Principal Trading Market on the Notice of
Exercise date.
v. Scrip.
No fractional shares or scrip representing fractional shares shall be issued upon the exercise of this Pre-Funded Warrant. As to any
fraction of a share which the Holder would otherwise be entitled to purchase upon such exercise, the Corporation shall, at its election,
either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the Exercise Price or
round up to the next whole share.
vi. Charges,
Taxes and Expenses. Issuance of Warrant Shares shall be made without charge to the Holder for any issue or transfer tax or other
incidental expense in respect of the issuance of such Warrant Shares, all of which taxes and expenses shall be paid by the Corporation,
and such Warrant Shares shall be issued in the name of the Holder or in the name or names of its qualified designee as may be directed
by the Holder.
vii. Closing
of Books. The Corporation will not close its shareholder books or records in any manner which prevents the timely exercise of this
Pre-Funded Warrant, pursuant to the terms hereof.
viii. Withholding
Taxes. If required by applicable laws, withholding taxes (including backup withholding) may be withheld by the Corporation from payments
and deemed payments on or with respect to this Pre-Funded Warrant, and Corporation shall remit any amounts deducted or withheld to the
appropriate governmental authority in the time and manner required by applicable laws, provided that the Corporation shall provide written
notice to the Holder of any anticipated deduction or withholding from any payment or deemed payments on or with respect to this Pre-Funded
Warrant promptly upon it becoming aware of such obligation to deduct or withhold and no later than five (5) days before the date
of the payment or deemed payment on which the deduction or withholding may possibly apply, and provided further that the Corporation
shall consider in good faith any reasonable objection raised by the Holder to such withholding and that the Corporation and the Holder
shall cooperate in good faith to reduce or eliminate any such deduction or withholding. In addition, if any withholding taxes (including
backup withholding) are paid on behalf of Holder, then those withholding taxes may be set off against payments of cash or the delivery
of Warrant Shares, if any, in respect of this Pre-Funded Warrant (or any payments on Common Shares) or sales proceeds received by, or
other funds or assets of, Holder. At the time of issuance of this Pre-Funded Warrant, the Corporation is not aware of any information
or fact that would result in deduction or withholding being applicable to any payments and deemed payment on or with respect to this
Pre-Funded Warrant.
d) Holder’s
Exercise Limitations.
i. Exchange
Act Limitations. The Corporation shall not effect any exercise of this Pre-Funded Warrant, and a Holder shall not have the right
to exercise any portion of this Pre-Funded Warrant, pursuant to Section 2 or otherwise, to the extent that after giving effect to
such issuance after exercise as set forth on the applicable Notice of Exercise, the Holder (together with the Holder’s Affiliates,
and any other Persons acting as a group together with the Holder or any of the Holder’s Affiliates (such Persons, “Attribution
Parties”)), would beneficially own in excess of the Beneficial Ownership Limitation (as defined below). For purposes of the
foregoing sentence, the number of Common Shares beneficially owned by the Holder and its Affiliates and Attribution Parties shall include
the number of Warrant Shares issuable upon exercise of this Pre-Funded Warrant with respect to which such determination is being made,
but shall exclude the number of Warrant Shares which would be issuable upon (i) exercise of the remaining, nonexercised portion
of this Pre-Funded Warrant beneficially owned by the Holder or any of its Affiliates or Attribution Parties and (ii) exercise or
conversion of the unexercised or nonconverted portion of any other securities of the Corporation (including, without limitation, any
other Common Share Equivalents) subject to a limitation on conversion or exercise analogous to the limitation contained herein beneficially
owned by the Holder or any of its Affiliates or Attribution Parties. Except as set forth in the preceding sentence, for purposes of this
Section 2d), beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act and the rules and
regulations promulgated thereunder, it being acknowledged by the Holder that the Corporation is not representing to the Holder that such
calculation is in compliance with Section 13(d) of the Exchange Act and the Holder is solely responsible for any schedules
required to be filed in accordance therewith. To the extent that the limitation contained in this Section 2d) applies, the determination
of whether this Pre-Funded Warrant is exercisable (in relation to other securities owned by the Holder together with any Affiliates and
Attribution Parties) and of which portion of this Pre-Funded Warrant is exercisable shall be in the sole discretion of the Holder, and
the submission of a Notice of Exercise shall be deemed to be the Holder’s determination of whether this Pre-Funded Warrant is exercisable
(in relation to other securities owned by the Holder together with any Affiliates and Attribution Parties) and of which portion of this
Pre-Funded Warrant is exercisable, in each case subject to the Beneficial Ownership Limitation, and the Corporation shall have no obligation
to verify or confirm the accuracy of such determination. In addition, a determination as to any group status as contemplated above shall
be determined in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder.
The “Beneficial Ownership Limitation” shall be 9.99% of the number of Common Shares outstanding immediately after
giving effect to the issuance of Warrant Shares issuable upon exercise of this Pre-Funded Warrant. The Holder, upon notice to the Corporation,
may decrease the Beneficial Ownership Limitation provisions of this Section 2d) and the provisions of this Section 2d) shall
continue to apply. Any change to the Beneficial Ownership Limitation will not be effective until the 61st day after such notice
is delivered to the Corporation. The provisions of this paragraph shall be construed and implemented in a manner otherwise than in strict
conformity with the terms of this Section 2d) to correct this paragraph (or any portion hereof) which may be defective or inconsistent
with the intended Beneficial Ownership Limitation herein contained or to make changes or supplements necessary or desirable to properly
give effect to such limitation. The limitations contained in this paragraph shall apply to a successor holder of this Pre-Funded Warrant.
ii. Toronto
Stock Exchange Limitations. So long as the Common Shares are listed on the TSX, the Holder shall not be permitted to exercise all
or any part of the Pre-Funded Warrants if, following such exercise, the Holder and its Affiliates and Attribution Parties would hold
more than (i) 9.99% of the number of Common Shares outstanding immediately following the issuance of the Warrant Shares issuable
upon exercise of this Pre-Funded Warrant, unless the Holder files a personal information form (PIF) with the TSX and provides the Corporation
with TSX approval of same, as required by the TSX, and (ii) 19.99% of the number of Common Shares outstanding immediately following
the issuance of the Warrant Shares issuable upon exercise of this Pre-Funded Warrant, unless the Corporation previously obtains approval
from its shareholders to proceed with such issuance in accordance with applicable laws and the rules of the TSX.
iii. Number
of outstanding Common Shares. For purposes of this Section 2d), in determining the number of outstanding Common Shares, the
Holder may rely on the number of outstanding Common Shares as reflected in (i) the Corporation’s most recent periodic or annual
filings publicly filed with Canadian securities regulatory authorities and available at www.sedarplus.ca, (ii) a more
recent public announcement by the Corporation or (iii) a more recent written notice by the Corporation or the Transfer Agent setting
forth the number of Common Shares outstanding. Upon the written or oral request of a Holder, the Corporation shall within two (2) Trading
Days confirm orally and in writing to the Holder the number of Common Shares then outstanding. In any case, the number of outstanding
Common Shares shall be determined after giving effect to the conversion or exercise of securities of the Corporation, including this
Pre-Funded Warrant, by the Holder or its Affiliates or Attribution Parties since the date as of which such number of outstanding Common
Shares was reported.
iv. Affiliated
Companies. For purposes of this Section 2d), a company shall be deemed to be an affiliate of another company if one of them
is the subsidiary of the other or if both are subsidiaries of the same company or if each of them is controlled by the same person or
company.
e) Payment
of Exercise Price. Notwithstanding anything contained herein to the contrary, the Holder may, in its sole discretion, if at such
time the Warrant Shares subject to an Exercise Notice may not be traded by the Holder on the Principal Trading Market pursuant to Regulation
S (other than as a result of the Holder becoming an “affiliate” (as such term is defined in Rule 144 under the U.S.
Securities Act) of the Corporation), satisfy its obligation to pay the Exercise Price through a “cashless exercise”, in which
event the Corporation shall issue to the Holder the number of Warrant Shares equal to the quotient obtained by dividing [(A-B) (X)] by
(A), where:
(A) = the VWAP per Common Share
on the Principal Trading Market for the 5-day period ending on the Trading Day immediately preceding the Exercise Date;
(B) = the
Exercise Price of this Per-Funded Warrant; and
(X) = the number of Warrant Shares
that would be issuable upon exercise of this Pre-Funded Warrant in accordance with the terms of this Pre-Funded Warrant if such exercise
were by means of a cash exercise rather than a cashless exercise.
If Warrant Shares are issued in such a cashless
exercise, the parties acknowledge and agree that in accordance with Section 3(a)(9) of the Securities Act of 1933, as amended,
the holding period of the Warrant Shares being issued may be tacked on to the holding period of this Pre-Funded Warrant, the Warrant
Shares shall take on the characteristics of the Pre-Funded Warrants being exercised. The Corporation agrees not to take any position
to the contrary.
Section 3. Certain
Adjustments.
a) Stock
Splits and Consolidation. If the Corporation, at any time while this Pre-Funded Warrant is outstanding: (i) subdivides outstanding
Common Shares into a larger number of shares, (ii) combines (including by way of reverse stock split) outstanding Common Shares
into a smaller number of shares, or (iii) issues by reclassification of the Common Shares, then in each case the Exercise Price
shall be multiplied by a fraction of which the numerator shall be the number of Common Shares outstanding immediately before such event
and of which the denominator shall be the number of Common Shares outstanding immediately after such event, and the number of shares
issuable upon exercise of this Pre-Funded Warrant shall be proportionately adjusted such that the aggregate Exercise Price of this Pre-Funded
Warrant shall remain unchanged. Any adjustment made pursuant to this Section 3.a) shall become effective immediately after the record
date for the determination of shareholders entitled to receive such dividend or distribution and shall become effective immediately after
the effective date in the case of a subdivision, combination or re-classification.
b) Rights
Offerings. If at any time the Corporation fixes a record date for the distribution to all or substantially all of the holders of
its outstanding Common Shares of rights, options or warrants entitling them, for a period expiring not more than 45 days after such
record date, to subscribe for or purchase Common Shares, or Common Share Equivalents, at a price per share to the holder (or at an exchange,
exercise or conversion price per share) of less than 95% of the VWAP of the Common Shares for the five trading days ending immediately
prior to the “ex-distribution” date with respect to such event (any such event being called a “Rights Offering”),
then the number of Warrant Shares the Holder is entitled to receive upon the exercise of this Pre-Funded Warrant shall be adjusted effective
immediately after such record date for the Rights Offering by multiplying the number of Warrant Shares the Holder is entitled to receive
upon the exercise of this Pre-Funded Warrant in effect immediately prior to such record date by a fraction:
i. the
numerator of which shall be the number of Common Shares which would be outstanding after giving effect to the Rights Offering (assuming
the exercise of all of the rights, options or warrants under the Rights Offering and assuming the exchange, exercise or conversion into
Common Shares of all exchangeable, exercisable or convertible securities issued upon exercise of such rights, options or warrants, if
any), and
ii. the
denominator of which shall be the aggregate of:
| (A) | the total number of Common Shares outstanding
as of the record date for the Rights Offering, and |
| (B) | a number of Common Shares determined by
dividing: |
| (I) | the
amount equal to the aggregate consideration payable on the exercise of all of the rights,
options and warrants under the Rights Offering plus the aggregate consideration, if any,
payable on the exchange, exercise or conversion of the exchangeable or convertible securities
issued upon exercise of such rights, options or warrants (assuming the exercise of all rights,
options and warrants under the Rights Offering and assuming the exchange or conversion of
all exchangeable or convertible securities issued upon exercise of such rights, options and
warrants); |
by
| (II) | the VWAP of the Common Shares for the five
trading days ending immediately prior to the “ex-distribution” date with respect
to the Rights Offering. |
c) Pro
Rata Distributions. During such time as this Pre-Funded Warrant is outstanding, if the Corporation shall fix a record date for the
issuance or distribution to all or substantially all the holders of its outstanding Common Shares of shares of the Corporation of any
class other than Common shares, rights, options or warrants to acquire Common Shares or securities exchangeable or exercisable or convertible
into Common Shares, evidence of indebtedness, cash, securities or any property or other assets (including, without limitation, any distribution
of cash, stock or other securities, property or options by way of a dividend, spin off, reclassification, corporate rearrangement, scheme
of arrangement or other similar transaction) (a “Special Distribution”), at any time after the issuance of this
Pre-Funded Warrant, then, in each such case, the number of Warrant Shares the Holder is entitled to receive upon the exercise of this
Pre-Funded Warrant shall be adjusted effective immediately after such record date for the Special Distribution by multiplying the number
of Warrant Shares the Holder is entitled to receive upon the exercise of this Pre-Funded Warrant in effect immediately prior to such
record date by a fraction:
i. the
numerator of which shall be the number of Common Shares outstanding on such record date multiplied by the VWAP of the Common Shares for
the five trading days ending immediately prior to the “ex-distribution” date with respect to the Special Distribution, and
ii. the
denominator of which shall be:
| (A) | the product of the number of Common Shares
outstanding on such record date and the VWAP of the Common Shares for the five trading days
ending immediately prior to the “ex-distribution” date with respect to the Special
Distribution, |
less
| (B) | the fair market value, as determined by
action by the board of directors of the Corporation acting reasonably and in good faith (whose
determination shall, absent manifest error, be conclusive, subject to the approval of the
TSX), to the holders of the Common Shares of the shares, rights, options, warrants, evidences
of indebtedness or property or other assets issued or distributed in the Special Distribution. |
d) Implementation
of a new Dividend Program. If the Corporation, at any time while this Pre-Funded Warrant is outstanding, fixes a record date for
the payment of cash dividends or distributions to holders of the Common Shares as part of the implementation of a new dividend program
(but not for ongoing distribution or dividends), the Exercise Price will be adjusted immediately after the record date fixed for the
payment of the inaugural dividend so that it will be equal to the price determined by multiplying the Exercise Price in effect on such
record date by a fraction:
i. the
denominator of which will be the VWAP for the five-day period ending two trading days prior to the record date (the “Pre
Record Date Price”), and
ii. the
numerator of which will be the Pre Record Date Price less the amount in cash per Common Share.
e) Fundamental
Transaction. If, at any time while this Pre-Funded Warrant is outstanding, (i) the Corporation, directly or indirectly, in one
or more related transactions effects any merger or consolidation of the Corporation with or into another Person, (ii) the Corporation,
directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or substantially
all of its assets in one or a series of related transactions, (iii) any, direct or indirect, purchase offer, tender offer or exchange
offer (whether by the Corporation or another Person) is completed pursuant to which holders of Common Share are permitted to sell, tender
or exchange their shares for other securities, cash or property and has been accepted by the holders of 50% or more of the outstanding
Common Share, (iv) the Corporation, directly or indirectly, in one or more related transactions effects any reclassification, reorganization
or recapitalization of the Common Share or any compulsory share exchange pursuant to which the Common Shares are effectively converted
into or exchanged for other securities, cash or property, or (v) the Corporation, directly or indirectly, in one or more related
transactions consummates a stock or share purchase agreement or other business combination (including, without limitation, a reorganization,
recapitalization, spin-off, merger or scheme of arrangement) with another Person or group of Persons whereby such other Person or group
acquires more than 50% of the outstanding Common Shares (not including any Common Shares held by the other Person or other Persons making
or party to, or associated or affiliated with the other Persons making or party to, such stock or share purchase agreement or other business
combination) (each a “Fundamental Transaction”), then, upon any subsequent exercise of this Pre-Funded Warrant,
the Holder shall have the right to receive, for each Warrant Share that would have been issuable upon such exercise immediately prior
to the occurrence of such Fundamental Transaction, at the option of the Holder, the number of Common Shares of the successor or acquiring
corporation or of the Corporation, if it is the surviving corporation, and any additional consideration (the “Alternate
Consideration”) receivable as a result of such Fundamental Transaction by a holder of the number of Common Shares for which
this Pre-Funded Warrant is exercisable immediately prior to such Fundamental Transaction (without regard to any limitation in Section 2.d)
on the exercise of this Pre-Funded Warrant). For purposes of any such exercise, the determination of the Exercise Price shall be appropriately
adjusted to apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one Common Share
in such Fundamental Transaction, and the Corporation shall apportion the Exercise Price among the Alternate Consideration in a reasonable
manner reflecting the relative value of any different components of the Alternate Consideration. If holders of Common Share are given
any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the Holder shall be given the same
choice as to the Alternate Consideration it receives upon any exercise of this Pre-Funded Warrant following such Fundamental Transaction.
The Corporation shall cause any successor entity in a Fundamental Transaction in which the Corporation is not the survivor (the “Successor
Entity”) to assume in writing all of the obligations of the Corporation under this Pre-Funded Warrant in accordance with the
provisions of this Section 3d) prior to such Fundamental Transaction and shall, at the option of the Holder, deliver to the Holder
in exchange for this Pre-Funded Warrant a security of the Successor Entity evidenced by a written instrument substantially similar in
form and substance to this Pre-Funded Warrant which is exercisable for a corresponding number of shares of capital stock of such Successor
Entity (or its parent entity) equivalent to the Warrant Shares acquirable and receivable upon exercise of this Pre-Funded Warrant (without
regard to any limitations on the exercise of this Pre-Funded Warrant) prior to such Fundamental Transaction, and with an exercise price
which applies the exercise price hereunder to such shares of capital stock (but taking into account the relative value of the Common
Shares pursuant to such Fundamental Transaction and the value of such shares of capital stock, such number of shares of capital stock
and such exercise price being for the purpose of protecting the economic value of this Pre-Funded Warrant immediately prior to the consummation
of such Fundamental Transaction). Upon the occurrence of any such Fundamental Transaction, the Successor Entity shall succeed to, and
be substituted for (so that from and after the date of such Fundamental Transaction, the provisions of this Pre-Funded Warrant referring
to the “Corporation” shall refer instead to the Successor Entity), and may exercise every right and power of the Corporation
and shall assume all of the obligations of the Corporation under this Pre-Funded Warrant with the same effect as if such Successor Entity
had been named as the Corporation herein.
f) Calculations.
All calculations under this Section 3 shall be made to the nearest cent or the nearest 1/100th of a share, as the case
may be. For purposes of this Section 3, the number of Common Shares deemed to be issued and outstanding as of a given date shall
be the sum of the number of Common Shares issued and outstanding.
g) Notice
to Holder.
i. Adjustment
to Exercise Price. Whenever the Exercise Price is adjusted pursuant to any provision of this Section 3, the Corporation shall
promptly deliver to the Holder by email a notice setting forth the Exercise Price after such adjustment and any resulting adjustment
to the number of Warrant Shares and setting forth a brief statement of the facts requiring such adjustment.
ii. Notice
to Allow Exercise by Holder. If (A) the Corporation shall declare a dividend (or any other distribution in whatever form) on
the Common Shares, (B) the Corporation shall declare a special nonrecurring cash dividend on or a redemption of the Common Shares,
(C) the Corporation shall authorize the granting to all holders of Common Shares rights or warrants to subscribe for or purchase
shares of any class or of any rights, (D) the approval of any shareholders of the Corporation shall be required in connection with
any reclassification of the Common Shares, any consolidation or merger to which the Corporation is a party, any sale or transfer of all
or substantially all of the assets of the Corporation, or any compulsory share exchange whereby the Common Shares are converted into
other securities, cash or property, or (E) the Corporation shall authorize the voluntary or involuntary dissolution, liquidation
or winding up of the affairs of the Corporation, then, in each case, the Corporation shall cause to be delivered by email to the Holder
at its email address as it shall appear upon the register of warrants maintained by the Corporation, at least 20 calendar days prior
to the applicable record or effective date hereinafter specified, a notice stating (x) the date on which a record is to be taken
for the purpose of such dividend, distribution, redemption, rights or warrants, or if a record is not to be taken, the date as of which
the holders of the Common Shares of record to be entitled to such dividend, distributions, redemption, rights or warrants are to be determined
or (y) the date on which such reclassification, consolidation, merger, sale, transfer or share exchange is expected to become effective
or close, and the date as of which it is expected that holders of Common Shares of record shall be entitled to exchange their Common
Shares for securities, cash or other property deliverable upon such reclassification, consolidation, merger, sale, transfer or share
exchange; provided that the failure to deliver such notice or any defect therein or in the delivery thereof shall not affect the validity
of the corporate action required to be specified in such notice. To the extent that any notice provided in this Pre-Funded Warrant constitutes,
or contains, material, non-public information regarding the Corporation or any of the Subsidiaries, the Corporation shall simultaneously
issue a news release to disclose the information in compliance with applicable Canadian securities laws. The Holder shall remain entitled
to exercise this Pre-Funded Warrant during the period commencing on the date of such notice to the effective date of the event triggering
such notice except as may otherwise be expressly set forth herein.
Section 4. Miscellaneous.
a) No
Transfer of Pre-Funded Warrant. This Pre-Funded Warrant is non-assignable, non-transferable and non-negotiable and may not be exercised
by or to the benefit of any person other than the Holder or its designee.
b) No
Rights as Shareholder Until Exercise; No Settlement in Cash. This Pre-Funded Warrant does not entitle the Holder to any voting rights,
dividends or other rights as a shareholder of the Corporation prior to the exercise hereof as set forth in Section 2.c)i, except
as expressly set forth in Section 3. In no event shall the Corporation be required to net cash settle an exercise of this Pre-Funded
Warrant.
c) Loss,
Theft, Destruction or Mutilation of Pre-Funded Warrant. The Corporation covenants that upon receipt by the Corporation of evidence
reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Pre-Funded Warrant or any certificate relating to
the Warrant Shares, and in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it (which, in the
case of the Pre-Funded Warrant, shall not include the posting of any bond), and upon surrender and cancellation of such Pre-Funded Warrant
or certificate, if mutilated, the Corporation will make and deliver a new Pre-Funded Warrant or certificate of like tenor and dated as
of such cancellation, in lieu of such Pre-Funded Warrant or certificate.
d) Saturdays,
Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of any right required or
granted herein shall not be a Business Day, then, such action may be taken or such right may be exercised on the next succeeding Business
Day.
e) Authorized
Shares.
The Corporation covenants
that the Warrant Shares have been duly authorized, allotted and reserved for issuance and will, upon exercise of the purchase rights
represented by this Pre-Funded Warrant and payment for such Warrant Shares in accordance herewith, be duly authorized, validly issued,
fully paid and non-assessable and free from all taxes, liens and charges created by the Corporation in respect of the issue thereof (other
than taxes in respect of any transfer occurring contemporaneously with such issue). The Corporation will take all such reasonable action
as may be necessary to assure that such Warrant Shares may be issued as provided herein without violation of any applicable law or regulation,
or of any requirements of the Trading Market upon which the Common Shares may be listed.
f) No
market. The Holder acknowledges that the Corporation has not applied and does not intend to apply to list the Pre-Funded Warrants
on any securities exchange or Trading Market.
g) Jurisdiction.
This Pre-Funded Warrant shall be governed by and construed in accordance with the laws of the Province of Ontario without regard to the
principles of conflicts of laws.
h) Restrictions.
The Holder acknowledges that the Warrant Shares acquired upon the exercise of this Pre-Funded Warrant, if not registered, will continue
to be subject to the Restricted Security Agreements as such term is defined in the Subscription Agreement.
i) Nonwaiver
and Expenses. No course of dealing or any delay or failure to exercise any right hereunder on the part of Holder shall operate as
a waiver of such right or otherwise prejudice the Holder’s rights, powers or remedies. Without limiting any other provision of
this Pre-Funded Warrant, if the Corporation willfully and knowingly fails to comply with any provision of this Pre-Funded Warrant, which
results in any material damages to the Holder, the Corporation shall pay to the Holder such amounts as shall be sufficient to cover any
costs and expenses including, but not limited to, reasonable attorneys’ fees, including those of appellate proceedings, incurred
by the Holder in collecting any amounts due pursuant hereto or in otherwise enforcing any of its rights, powers or remedies hereunder.
j) Notices.
All communications hereunder shall be in writing and shall be mailed, hand delivered or sent via email and confirmed to the parties hereto
as follows:
| If to the Holder: |
RA Capital Healthcare Fund, L.P. |
| |
200 Berkeley Street, 18th Floor |
| |
Boston, MA 02116 |
| |
Attention: General Counsel |
| |
Email: legal@racap.com |
| |
|
| with a copy to: |
Osler, Hoskin & Harcourt LLP |
| |
1000 De La Gauchetière Street West, Suite 2100 |
| |
Montreal QC H3B 4W5 |
| |
Attention : François Paradis and Jeremy Brisset |
| |
Emails : fparadis@osler.com; jbrisset@osler.com |
| |
|
| and |
Cooley LLP |
| |
500 Boylston St., 14th Floor |
| |
Boston, MA 02116 |
| |
Attention: Eric Blanchard |
| |
Email: eblanchard@cooley.com |
| |
|
| If to the Corporation: |
Medicenna Therapeutics Corp. |
| |
2 Bloor St. W., 7th Floor |
| |
Toronto ON M4W 3E2 |
| |
Attention: Fahar Merchant and David Hyman |
| |
Emails: fmerchant@medicenna.com; dhyman@medicenna.com |
| |
|
| with a copy to: |
McCarthy Tétrault LLP |
| |
500 Grande-Allée Est, 9e étage |
| |
Québec QC G1R 2J7 |
| |
Attention: Charles-Antoine Soulière and Laurence Cromp-Lapierre |
| |
Emails: casouliere@mccarthy.ca; lcromplapierre@mccarthy.ca |
| |
|
| and |
Troutman Pepper Hamilton Sanders LLP |
| |
125 High Street |
| |
19th Floor |
| |
Boston, MA 02110 |
| |
Attention: Thomas M. Rose; Shona Smith |
| |
Emails: thomas.rose@troutman.com; shona.smith@troutman.com |
k) Successors
and Assigns. Subject to applicable securities laws, this Pre-Funded Warrant and the rights and obligations evidenced hereby shall
inure to the benefit of and be binding upon the successors and permitted assigns of the Corporation and the successors and permitted
assigns of Holder. The provisions of this Pre-Funded Warrant are intended to be for the benefit of any Holder from time to time of this
Pre-Funded Warrant and shall be enforceable by the Holder or holder of Warrant Shares.
l) Amendment.
Subject to the prior written approval of the Principal Trading Market, this Pre-Funded Warrant may be modified or amended or the provisions
hereof waived with the written consent of the Corporation, on the one hand, and the Holder, on the other hand.
m) Severability.
Wherever possible, each provision of this Pre-Funded Warrant shall be interpreted in such manner as to be effective and valid under applicable
law, but if any provision of this Pre-Funded Warrant shall be prohibited by or invalid under applicable law, such provision shall be
ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provisions or the remaining provisions
of this Pre-Funded Warrant.
n) Headings.
The headings used in this Pre-Funded Warrant are for the convenience of reference only and shall not, for any purpose, be deemed a part
of this Pre-Funded Warrant.
(Signature Page Follows)
IN WITNESS WHEREOF, the Corporation
has caused this Pre-Funded Warrant to be executed by its officer thereunto duly authorized as of the date first above indicated.
| |
MEDICENNA
THERAPEUTICS CORP. |
| |
|
| |
By: |
(s) Fahar
Merchant |
| |
|
Name: Fahar Merchant |
| |
|
Title: Chairman, President
and Chief Executive Officer |
[Signature Page - Warrant]
NOTICE
OF EXERCISE
To:
Medicenna Therapeutics Corp. (the “Corporation”)
Reference is made
to the attached warrant certificate issued by the Corporation on April 30, 2024 for an aggregate of ______________________________
pre-funded common share purchase warrants to the undersigned Holder (the “Pre-Funded Warrant”). Any capitalized
terms used herein and otherwise undefined shall have the meaning ascribed to them in the Pre-Funded Warrant.
(1) The
undersigned hereby elects to purchase _______________________ Warrant Shares of the Corporation pursuant to the terms of the attached
Pre-Funded Warrant (only if exercised in full), and tenders herewith payment of the exercise price in full.
(2) Payment
shall take the form in lawful money of Canada.
(3) Please
register said Warrant Shares as specified below:
_______________________________
_______________________________
_______________________________
The Warrant Shares shall be delivered to the
address specified below:
_______________________________
_______________________________
_______________________________
The undersigned represents, warrants and certifies
as follows that (one (only) of the following must be checked):
| ¨ | (A) the
undersigned holder at the time of exercise of the Pre-Funded Warrant (i) is not a U.S.
Person, (ii) is not in the United States, (iii) is not exercising the Pre-Funded
Warrant for the account or benefit of a person in the United States or a U.S. Person, (iv) did
not execute or deliver this notice of exercise in the United States and (v) delivery
of the underlying Warrant Shares will not be to an address in the United States; OR |
| ¨ | (B) the
undersigned holder (a) is the original U.S. purchaser who purchased the Pre-Funded Warrant
pursuant to the Corporation’s offering who delivered a Subscription Agreement in connection
with its purchase of Common Shares and Pre-Funded Warrants in the Offering (the “Subscription
Agreement”), (b) is exercising the Pre-Funded Warrant for its own account
or for the account of a disclosed principal that was named in the Subscription Agreement,
(c) is, and such disclosed principal, if any, is a “qualified institutional buyer”
as defined in Rule 144A under the U.S. Securities Act of 1933, as amended (the “U.S.
Securities Act”), that is also an “accredited investor” as defined
in Rule 501(a) of Regulation D under the U.S. Securities Act (a “QIB”)
at the time of exercise of this Pre-Funded Warrant and the representations, warranties and
covenants of the holder made in the Subscription Agreement remain true and correct as of
the date of exercise of this Pre-Funded Warrant, and (d) represents, warrants and covenants
that the Pre-Funded Warrant Shares received on exercise of the Pre-Funded Warrant may only
be offered, sold, pledged, or otherwise transferred, directly or indirectly: (A) to
the Corporation, or (B) outside the United States in accordance with Rule 904 of
Regulation S under the U.S. Securities Act and in compliance with applicable local laws or
regulations. |
“United States” and “U.S. Person”
are as defined in Rule 902 of Regulation S under the U.S. Securities Act.
The undersigned, as of the date herein (the “Date
of Exercise”)
| (i) | represents that the Holder currently owns,
directly or indirectly, _____________ Common Shares, which includes any Common Shares
held by parties acting in combination or in concert with the Holder; |
| (ii) | acknowledges
that, pursuant to section 2.d) of the Pre-Funded Warrant certificate that so long as
the Common Shares are listed on the TSX, the Holder shall not be permitted to exercise
all or any part of the Pre-Funded Warrants if, following such exercise, the Holder and its
Affiliates and Attribution Parties would hold more than: |
| A. | 9.99%
of the number of Common Shares outstanding immediately following the issuance of the Warrant
Shares issuable upon exercise of this Pre-Funded Warrant, unless the Holder files a personal
information form (“PIF”) with the TSX and provides the Corporation with
TSX approval of same, as required by the TSX (the “New Insider Limitation”);
and |
| B. | 19.99%
of the number of Common Shares outstanding immediately following the issuance of the Warrant
Shares issuable upon exercise of this Pre-Funded Warrant, unless the Corporation previously
obtains approval from its shareholders to proceed with such issuance in accordance with applicable
laws and the rules of the TSX (the “Control Limitation”); |
| (iii) | and acknowledges that the proposed exercise
of the Pre-Funded Warrants (the “Exercise”) is subject to acceptance
by the Corporation as provided under “Acceptance” below, and that the Corporation
may refuse, in totality or in part, the Exercise if such Exercise would not comply with the
New Insider Limitation or the Control Limitation (but for no other reason). |
Certificate
The undersigned, in its capacity as _____________________
of the Holder, has made all reasonable inquiries to ensure that the information provided in this Notice of Exercise is accurate.
| Name of Holder: |
|
|
| |
|
|
| Signature of Authorized Signatory of Holder: |
|
|
| |
|
|
| Name of Authorized Signatory: |
|
|
| |
|
|
| Title of Authorized Signatory: |
|
|
| |
|
|
| Date: |
|
|
ACCEPTANCE
The undersigned, in its capacity as a senior
officer of the Corporation, certifies that he or she has verified the information provided in the Notice of Exercise and that, to the
best of the knowledge of the undersigned and based on the information provided by the Holder, such information is accurate.
New Insider Limitation
As of the Date of Exercise, a PIF:
| (i) | ¨ has
been filed and approved by the TSX; or |
| (ii) | ¨ has
not been filed and approved by the TSX and, further to the exercise of the Pre-Funded Warrants,
the Holder, its Affiliates and Attribution Parties will hold an aggregate of ______________________
Common Shares, representing ______% of the then issued and outstanding Common Shares. |
Accordingly, the undersigned confirms that the
Exercise complies with the New Insider Limitation.
Control Limitation
As of the Date of Exercise, shareholder approval
of the issuance to the Holder of Common Shares representing 19.99% or more of the issued and outstanding Common Shares:
| (i) | ¨ has
been obtained; or |
| (ii) | ¨ has
not been obtained and, further to the exercise of the Pre-Funded Warrants, the Holder, its
Affiliates and Attribution Parties will hold an aggregate of ______________________ Common
Shares, representing ______% of the then issued and outstanding Common Shares. |
Accordingly, the undersigned confirms that the
Exercise complies with the Control Limitation.
Based on the confirmations provided herein and
in the Notice of Exercise, the undersigned confirms acceptance by the Corporation of the Exercise.
| |
MEDICENNA
THERAPEUTICS CORP. |
| |
|
| |
By: |
|
| |
|
Name: |
| |
|
Title: |
Medicenna Therapeutics (NASDAQ:MDNA)
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