This Amendment No. 16 hereby amends and supplements the statement of beneficial ownership on Schedule
13D, relating to the common stock, $0.001 par value per share (the Issuer Common Stock), of Lexicon Pharmaceuticals, Inc., a Delaware corporation (the Issuer or Lexicon), initially filed on
June 27, 2007, as amended by Amendment No. 1 thereto filed on August 24, 2007, Amendment No. 2 thereto filed on August 29, 2007, Amendment No. 3 thereto filed on October 8, 2009, Amendment No. 4 thereto filed
on October 15, 2009, Amendment No. 5 thereto filed on March 19, 2010, Amendment No. 6 thereto filed on August 15, 2011, Amendment No. 7 thereto filed on November 14, 2011, Amendment No. 8 thereto filed on
December 27, 2011, Amendment No. 9 thereto filed on February 24, 2012, Amendment No. 10 thereto filed on April 10, 2012, Amendment No. 11 thereto filed on October 26, 2012, Amendment No. 12 thereto filed on
November 26, 2014, Amendment No. 13 thereto filed on June 4, 2018, Amendment No. 14 thereto filed on June 29, 2018 and Amendment No. 15 thereto filed on December 16, 2020 (as so amended, the
Statement). This Amendment reflects, among other things, that in connection with an internal reorganization that became effective on December 31, 2020 (the Reorganization), the removal of Invus C.V. as a Reporting
Person on this Schedule 13D as a result of its dissolution, and the addition of Invus Partners, LLC as a Reporting Person. All capitalized terms not otherwise defined herein have the meaning assigned to them in the Statement.
Item 2. Identity and Background
Item 2 of
the Statement is hereby amended and restated in its entirety as follows:
This statement is being filed jointly by Invus, L.P., a Bermuda limited
partnership, Invus Advisors, L.L.C., a Delaware limited liability company, Invus Public Equities, L.P., a Bermuda limited partnership, Invus Public Equities Advisors, LLC, a Delaware limited liability company, Artal Treasury Limited, a Guernsey
company, Invus Partners, LLC, a Delaware limited liability company, Ulys, L.L.C., a Delaware limited liability company, Mr. Raymond Debbane, a citizen of Panama, Artal International S.C.A., a Luxembourg limited partnership, Artal International
Management S.A., a Luxembourg société anonyme, Artal Group S.A., a Luxembourg société anonyme, Westend S.A., a Luxembourg société anonyme (Westend), Stichting Administratiekantoor Westend,
a Netherlands foundation (the Stichting), and Mr. Pascal Minne, a citizen of Belgium (collectively, the Invus Parties).
The address of the principal place of business and principal office of Invus, L.P., Invus Public Equities, L.P., Invus Partners, LLC, Invus Advisors, L.L.C.,
Invus Public Equities Advisors, LLC and Ulys, L.L.C. is c/o The Invus Group, LLC, 750 Lexington Avenue, 30th Floor, New York, NY 10022. The business address for Mr. Debbane is c/o The Invus Group, LLC, 750 Lexington Avenue, 30th Floor, New
York, NY 10022. The address of the principal place of business and principal office of Artal Treasury Limited is Suite 4, Borough House, rue du Pré, St. Peter Port, Guernsey GY1 3JJ. The address of the principal place of business and
principal office of Artal International S.C.A., Artal International Management S.A., Artal Group S.A. and Westend is 44, Rue De La Vallée, L-2661, Luxembourg, Luxembourg. The address of the principal
place of business and principal office of the Stichting is Claude Debussylaan, 46, 1082 MD Amsterdam, The Netherlands. The business address for Mr. Minne is 8 Clos du Bocage, B-1332 Genval, Belgium.
Invus, L.P., Invus Public Equities, L.P. and Invus Partners, LLC, which are controlled by Invus Advisors, L.L.C., Invus Public Equities Advisors, LLC and
Ulys, L.L.C., respectively, are principally engaged in the business of investing in securities. Invus Public Equities Advisors, LLC, which is controlled by Artal Treasury Limited, is primarily engaged in the business of serving as the general
partner of Invus Public Equities, L.P. Invus Advisors, L.L.C. and Artal Treasury Limited, which are controlled by Artal International S.C.A., are principally engaged in the business of serving as the general partner of Invus, L.P. and as the
managing member of Invus Public Equities Advisors, LLC, respectively. Ulys, L.L.C. is principally engaged in the business of serving as the managing member of Invus Partners, LLC. Mr. Debbane is the sole member of Ulys, L.L.C., and his present
occupation is serving as President of The Invus Group, LLC and Chief Executive Officer of Artal Group S.A. Mr. Debbane is also Chairman of the board of directors of the Issuer and Chairman of the board of directors of WW International, Inc.
Artal International S.C.A., a subsidiary of Artal Group S.A., is principally engaged in the business of owning its subsidiaries. Artal International Management S.A., a subsidiary of Artal Group S.A, is principally engaged in the business of managing
Artal International S.C.A. Artal Group S.A., a subsidiary of Westend, is principally engaged in the business of owning Artal International Management S.A., and Artal International S.C.A. and its subsidiaries. Westend, a subsidiary of the Stichting,
is principally engaged in the business of owning Artal Group S.A. and its subsidiaries. The Stichting is principally engaged in the business of owning Westend and its subsidiaries. Mr. Minne is the sole member of the board of the Stichting,
which is his present principal occupation.