FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Portnoy Mark L.		 2. Issuer Name and Ticker or Trading Symbol

CRYO CELL INTERNATIONAL INC [ CCEL ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    __X__ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Co-CEO
(Last)          (First)          (Middle)

700 BROOKER CREEK BLVD, SUITE 1800		 3. Date of Earliest Transaction (MM/DD/YYYY)

4/8/2022
(Street)

OLDSMAR, FL 34677
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

12/22/2022 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock         42266 I By 401K 
Common Stock         71529 I By Partnership (1)
Common Stock         762514 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option $3.14           4/15/2016 4/15/2026 Common Stock 59459  59459 D  
Stock Option $7.92           3/8/2018 3/8/2028 Common Stock 20000  20000 D  
Stock Option $7.53           8/30/2019 8/30/2029 Common Stock 22222  22222 D  
Stock Option $7.28           12/20/2019 (2)12/20/2029 Common Stock 20000  20000 D  
Stock Option $13.50 12/22/2021  D     20000  12/22/2021 12/22/2024 Common Stock 20000 $13.50 0 D  
Stock Option $12.27 12/22/2021  D (3)    100000  12/22/2021 12/22/2028 Common Stock 100000 $12.27 0 D  
Stock Option $13.50 4/8/2022  A (4)  20000    12/22/2022 (5)12/22/2024 Common Stock 20000 $13.50 20000 D  
Stock Option $12.27 4/8/2022  A (4)  100000    12/22/2022 (6)12/22/2028 Common Stock 100000 $12.27 100000 D  
Explanation of Responses:
(1) Shares of Common Stock held by Capital Asset Fund #1 Limited Partnership, as to which Mark L. Portnoy may be deemed the beneficial owner as its general partner.
(2) Stock options will vest 1/3 on the date of grant, 1/3 on December 1, 2020 and 1/3 on December 1, 2021.
(3) On April 8, 2022, the stock options were cancelled by mutual agreement of the reporting person and the issuer.
(4) The stock options are subject to the approval of the 2022 Equity Incentive Plan, which vote is expected to occur at the Company's 2022 Annual Meeting.
(5) One-third of the stock options will vest on December 22, 2022, one-third will vest on January 22, 2023 and one-third on January 22, 2024.
(6) Stock options vest immediately when the price of the Company's stock reaches $25.00 per share during the seven-year option term.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Portnoy Mark L.
700 BROOKER CREEK BLVD
SUITE 1800
OLDSMAR, FL 34677		XXCo-CEO
Signatures
/s/ Mark Portnoy4/14/2022
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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