Filed by Celgene Corporation
pursuant to Rule 425 under the Securities Act of 1933
and deemed filed pursuant to Rule 14a-12
under the Securities Exchange Act of 1934
Filer: Celgene Corporation
Subject Company: Celgene Corporation
SEC File No.: 001-34912
Form S-4 filed by Bristol-Myers Squibb File
No.: 333-229464
Date: February 19, 2019
Explanatory Note: The
following materials were provided to employees of Celgene Corporation on February 19, 2019.
Focus
on BMS Marketed Portfolio
|
At Bristol-Myers Squibb, we work every day to discover, develop
and deliver transformational medicines for patients with serious diseases. In 2007, we embarked on a bold strategy to create a
new business model combining the innovation and agility of a biotech with the reach and resources of a major pharma company. Twelve
years later, this biopharma model has delivered significant growth for the company and value for our patients and shareholders.
Our marketed portfolio includes innovative medicines targeting
hard-to-treat diseases. We focus on the specialty therapeutic areas of oncology, immunoscience and cardiovascular diseases. The
company's top brands today include
Opdivo, Eliquis, Orencia, Sprycel
and
Yervoy
.
Bristol-Myers
Squibb Marketed Oncology Portfolio
Opdivo
(nivolumab) is a programmed death-1 (PD-1) immune checkpoint inhibitor that is designed to uniquely harness
the body’s own immune system to help restore anti-tumor immune response. By harnessing the body’s own immune system
to fight cancer,
Opdivo
has become an important treatment option across multiple cancers.
Opdivo
’s leading global development program
is based on Bristol-Myers Squibb’s scientific expertise in the field of Immuno-Oncology, and includes a broad range of clinical
trials across all phases, including Phase 3, in a variety of tumor types. To date, the
Opdivo
clinical development
program has enrolled more than 25,000 patients. The
Opdivo
trials have contributed to gaining a deeper understanding
of the potential role of biomarkers in patient care, particularly regarding how patients may benefit from
Opdivo
across
the continuum of PD-L1 expression.
In July 2014,
Opdivo
was the first PD-1 immune
checkpoint inhibitor to receive regulatory approval anywhere in the world.
Opdivo
is currently approved in more
than 65 countries, including the United States, the European Union, Japan and China. In October 2015, the Company’s
Opdivo
and
Yervoy
combination regimen was the first immuno-oncology combination to receive regulatory approval for the treatment
of metastatic melanoma and is currently approved in more than 50 countries, including the United States and the European Union.
Bristol-Myers Squibb and Ono Pharmaceutical Co. jointly develop
and market
Opdivo,
with Ono responsible for Japan, South Korea and Taiwan and Bristol-Myers Squibb responsible for the rest
of the world.
For more information on
Opdivo
, please visit
Opdivo.com
For more information on immuno-oncology,
please visit
https://www.immunooncology.com/
Yervoy
(ipilimumab) was the first immuno-oncology
agent approved globally in 2011.
Yervoy
is a monoclonal antibody that works to activate the immune system by
targeting CTLA-4 (cytotoxic T-lymphocyte-associated antigen-4), a protein receptor that downregulates the immune system.
Yervoy
is approved for unresectable or metastatic melanoma in more than 50 countries. There is a broad, ongoing development
program in place for
Yervoy
spanning multiple tumor types.
For more information on
Yervoy
, please visit
Yervoy.com
Sprycel
first received FDA approval in 2006 for the treatment
of adults with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase (CP) who are resistant or
intolerant to prior therapy including imatinib. At that time,
Sprycel
also received FDA approval for adults with
Ph+ acute lymphoblastic leukemia (ALL) who are resistant or intolerant to prior therapy.
Sprycel
is approved and
marketed for these indications in more than 60 countries.
Sprycel
is also an FDA-approved treatment for adults
with newly diagnosed Ph+ CML-CP and is approved for this indication in more than 50 countries.
Both the FDA and the European Commission approved the expansion
of
Sprycel’s
indication to include pediatric patients with Ph+ CML-CP in November 2017 and July 2018.
For more information on
Sprycel
, please visit
Sprycel.com
Empliciti
(elotuzumab) is an immunostimulatory antibody
that specifically targets Signaling Lymphocyte Activation Molecule Family member 7 (SLAMF7), a cell-surface glycoprotein. SLAMF7
is expressed on myeloma cells independent of cytogenetic abnormalities. SLAMF7 also is expressed on Natural Killer cells, plasma
cells and at lower levels on specific immune cell subsets of differentiated cells within the hematopoietic lineage.
Empliciti
has a dual mechanism-of-action. It directly
activates the immune system through Natural Killer cells via the SLAMF7 pathway.
Empliciti
also targets SLAMF7
on myeloma cells, tagging these malignant cells for Natural Killer cell-mediated destruction via antibody-dependent cellular toxicity.
Empliciti
was initially approved by the FDA in 2015
in combination with Revlimid (lenalidomide) and dexamethasone for the treatment of patients with multiple myeloma who have received
one to three prior therapies.
Bristol-Myers Squibb and AbbVie are co-developing
Empliciti
,
with Bristol-Myers Squibb solely responsible for commercial activities.
For more information on
Empliciti
, please visit
Empliciti.com
Bristol-Myers Squibb Marketed
Innovative Medicines Portfolio
Eliquis
(apixaban) is an oral selective Factor Xa inhibitor.
By inhibiting Factor Xa, a key blood clotting protein,
Eliquis
decreases thrombin generation and blood clot formation.
Eliquis
is approved for multiple indications based on efficacy and safety data from multiple Phase 3 clinical trials.
Eliquis
is
a prescription medicine indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
(NVAF); for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone
hip or knee replacement surgery; for the treatment of DVT and PE; and to reduce the risk of recurrent DVT and PE, following initial
therapy.
Eliquis
is the No. 1 prescribed oral anti-coagulant in
the U.S. and the No. 1 prescribed novel oral anti-coagulant in the world.
Bristol-Myers Squibb and Pfizer jointly develop and market
Eliquis
combining Bristol-Myers Squibb's long-standing strengths in cardiovascular drug development and commercialization with
Pfizer’s global scale and expertise in this field.
For more information on
Eliquis
, please visit
Eliquis.com
Orencia
(abatacept) is an immunomodulator that disrupts
the continuous cycle of T-cell activation that characterizes rheumatoid arthritis (RA), thereby inhibiting the production of B-cell
derived autoantibodies and proimflammatory cytokines. Approved for the treatment for adult RA, juvenile idiopathic arthritis and
adult psoriatic arthritis (PsA),
Orencia
has been in clinical development for more than 13 years. There are three
administration options available for
Orencia
: intravenous infusion (once-a-month procedure at the doctor’s office),
prefilled syringe (once-weekly injection that can be done at home after training with a doctor) and the ClickJect™ Autoinjector
(once-weekly self-injection approved for use only by adults with moderate to severe RA or
active PsA).
For more than two decades, Bristol-Myers Squibb has
pioneered research into the body’ immune system aimed at discovering and developing medicines that harness
immunomodulation to treat disease.
For more information on
Orencia
, please visit
Orencia.com
.
Eliquis 10
Million Patients and Counting
Cardiovascular diseases has long been an important therapeutic
area for Bristol-Myers Squibb and our research and development efforts have led to a number of important treatment options for
patients over the past decades. Our priority product,
Eliquis
(apixaban)
,
is the No. 1 prescribed oral anti-coagulant
in the U.S. and the No. 1 prescribed novel oral anti-coagulant in the world.
Beyond outstanding sales
performance,
Eliquis
is making a significant difference for millions of patients across the globe.
Approximately 10 million patients have been treated with
Eliquis
since its launch in 2013. This means that
10 million people received a therapy that significantly reduced their risk of experiencing a stroke, pulmonary embolism
or major bleeding compared with the historical standard of care. When we consider the efficacy and safety profile
of
Eliquis
, we are incredibly proud of the work we do and the differentiated impact we are making on the
lives of so many people across the globe.
This milestone is not reached without meaningful
contributions from colleagues across the Bristol-Myers Squibb enterprise. To start,
Eliquis
was discovered
and developed by BMS scientists. Colleagues in Medical and HEOR (Health Economics and Outcomes Research) have also played
critical roles generating clinical trial and real-world data evidence. Additionally, the Global Product Development and
Supply team built a robust manufacturing and supply operation to support the rapid growth of
Eliquis
; an
operation that recently withstood a devastating hurricane in Puerto Rico with no interruption to global supply.
Last year, in recognition
of their strong research advancements, a team of Bristol-Myers Squibb scientists received the prestigious 2018 Sir James Black
award from the British Pharmacological Society for their contributions in the discovery of Eliquis.
Behind the
Design of the
Eliquis
Starter Pack
Contributions of GPS Field Sales Force Help Make a Commercial-led Project a Reality
As the GPS Strategic
Product Lead (SPL) for Eliquis at the time of the starter pack's development,
Fritz Lloyd was on point for delivering the GPS resources needed to make this Commercial-led project a reality.
There's more to the job of the sales force than selling medicines,
says Executive Institutional Territory Business Manager Chris van der Kieft, a member of the cardiovascular sales force whose clients
include some of Boston's major medical centers. Another responsibility is taking feedback from customers to make our products and
services even better. And there's more to the job of GPS than making medicines, says Fritz Lloyd, the GPS strategic product
leader for
Opdivo,
and previously
Eliquis
. It's also about providing ideas and solutions that help Commercial succeed. The
development of the first
Eliquis
Starter Pack for patients starting treatment for deep vein thrombosis (DVT) or pulmonary
embolism (PE) proved them both right.
When a competitor was first to market with a starter pack for
new DVT patients the BMS U.S.
Eliquis
VTE Professional Marketing Lead John Hidalgo was determined to make a better one. "Listening
to what our customers had to say was our first priority," said Hidalgo. Today, with the finished product now in
doctors' hands, van der Kieft said his customers couldn't be happier with the results. "They know BMS is listening to
what they're saying," he said. "Their reaction is: 'Thank you for helping us treat our patients.'"
"The
result is a product that makes it simple for patients to follow the dosing, and gives comfort to doctors and hospitals that their
patients have everything they need to start their treatment," said U.S. Eliquis VTE Professional Marketing Lead John
Hidalgo.
Executive Institutional
Territory Business Manager Chris van der Kieft, a member of the cardiovascular
sales force whose clients include some of Boston's major medical centers.
The Need
DVT is a blood clot in a deep vein
that limits blood flow. Sometimes a clot breaks free and travels to the lungs to become a pulmonary embolism, which can be fatal.
Doctors have traditionally prescribed warfarin for DVT/PE treatment, but the newer Direct-Acting Oral Anticoagulants (DOACs) such
as
Eliquis
are gaining ground. Like
Eliquis
,
Warfarin
, also known by the brand name
Coumadin
, is a
medicine in BMS' established brands and part of Innovative Medicines.
For patients, starting treatment with
a DOAC can be confusing. Dosing changes as the patient comes onto the treatment and that can sometimes present challenges to adherence.
DOAC patients also require less
frequent follow-up testing. That's one of their advantages, but it means fewer chances for physicians to ask if patients are
taking their medicine compliantly. Furthermore, patients often get their first prescriptions at a hospital after a thrombotic
event such as a blood clot. Shaken by that experience, they may not be in the best state to process the prescribing
instructions.
Finally, hospital patients like these
will typically get follow-up care from their cardiologist or primary care doctor. The health care system in general and hospitals
in particular are increasingly focused on how to better support patients through these "transitions of care.” Insights
like these validated the marketing team's market assessment on the need for a DVT/PE
Eliquis
starter pack and what it would
take to succeed.
"Chris helped us confirm the
need from the marketplace," said U.S.
Eliquis
VTE Professional Marketing Lead John Hidalgo. "His insights
validated the marketing team's view that a starter pack would provide real benefits to patients, physicians and
hospitals." With the need confirmed, it was time to execute.
The Eliquis
starter pack for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE)
is designed to help patients take
their medicine compliantly.
Delivering for Patients
As the strategic product leader for
Eliquis
for Global Product Development and Supply (GPS), Lloyd was on point for delivering the manufacturing and supply
resources needed to bring the project launched by Hidalgo and the market research, medical strategy, regulatory and marketing teams
to the finish line. Given its complexity, GPS proved to be a key partner by providing ideas and solutions for overcoming a variety
of challenges.
These included designing a box
with two cartons or "wallets" in such a way that patients could easily understand which carton to use first.
Designing for child-resistance was another challenge. The innovative solution was a design requiring a two-handed opening
technique in which patients push the carton in one location and pull the tablet out from another.
A final hurdle was building the
machinery to mass-produce the starter pack. In this, Lloyd credited the GPS External Manufacturing team led by Sean O'Leary
for its exceptional accountability and passion in working with BMS stakeholders, vendors and contract
manufacturers.
"The team persevered through
multiple design and production challenges to deliver this high priority product on time," said Lloyd, GPS strategic
product lead for
Opdivo
. "We set out and developed the starter pack having patients in mind," said
Hidalgo. "The result is a product that makes it simple for patients to follow the dosing, and gives comfort to
doctors and hospitals that their patients have everything they need to start their treatment. It is truly a win-win for
patients and providers."
China Global
Buddy Program Helps Accelerate
Opdivo
Approval
Xiaoqing Zhang, senior principal scientist
and a PAN China chapter lead, and Summer Shi, regulatory
coordination lead, talk with Chief Scientific Officer Tom Lynch
about the effectiveness and the value of the PAN Buddy Program.
With the June 15 announcement that the China National Drug Administration
(CNDA) has approved the first Immuno-Oncology agent,
Opdivo
, for the treatment of second-line non-small cell lung cancer
(NSCLC), it seems that BMS China has beaten its global competitors to market.
Since 2015, significant achievements have been made by the
health authority in China to accelerate approvals in prioritized areas, such as oncology, by encouraging innovation as
quickly as possible. These significant achievements are enabling China to move faster – participating in global trials
and accelerating timelines for Clinical Trial Applications (CTAs). In short: China is moving faster than ever, and
Bristol-Myers Squibb (BMS) must move just as quickly to stay ahead of the competition in this important market.
China
is moving faster than ever, and Bristol-Myers Squibb (BMS) must move just as quickly to stay ahead of the competition in this
important market.
Innovating
to Accelerate Approvals
To do so, BMS' PAN Asian Network (PAN) People Business and
Resource Group (PBRG) and the China R&D organization launched the PAN China Global Buddy Program in October of 2017. The
program is designed to address a dramatic increase in workload since BMS China's integration in global development last year
– now with 40 clinical studies to be initiated/completed in IO before the end of 2018 – and quickly onboard a
talent pool with little global experience. In fact, limited local talent combined with high demand and a high turnover
rate, between two to three years, were having a negative effect on BMS China.
According to Jing Yang, senior principal scientist and a PAN
Tri-chair, the initiative is "just one more way that the PAN PRBG is helping to drive business results."
The PAN Buddy Program is a four-week shadowing rotation
for BMS China employees to visit a BMS facility in the United States. The goal of the program is to provide role-specific
training to facilitate the efficient integration of new hires into BMS; establish a global-China network and improve
communications; establish a new industry standard with a PBRG promoting employee retention; and provide leadership
development opportunities via PBRG, as the trainees become PAN site leads at the end of their training session.
Eligible China R&D trainees (~10 trainees per
session; 2 sessions per year) are selected by BMS China function heads and are focused on employees who have at least six
months with BMS China, and who regularly interact with leadership in an important role. Their buddies are U.S. R&D
employees who work in functions relevant to the needs of the trainee. This program is designed to create long-term
relationships so that buddies will continue to help their Chinese counterparts to navigate their way through the global teams
after the face-to-face coaching is finished.
The PAN Buddy Program is a four-week shadowing
rotation for BMS China employees to visit a BMS facility in the United States.
The idea for the Buddy program was first introduced during the
2017 R&D Symposium, and the first participant, Xiaoqing Zhang, met her global buddies Nivedita Annur, and Yali Fu, Clinical
Trial Leads, at the Princeton Pike facility last October.
The program is delivering good results for both BMS and the
PAN group, whose membership is increasing as the China buddies become PBRG ambassadors. "Our first China buddy, Xiaoqing Zhang,
Medical Director of BMS China, has become a PAN site lead and helped to launch our China chapter in December," said Jing.
"It's very exciting to see the China buddies helping to drive the growth of BMS and of PAN in China."
To date, a total of 16 candidates have enrolled in the program,
with two sessions completed and three in progress.
"As a relatively new member of the company, as compared
to other participants, I think I have benefited the most from the in-person and personal contact with relevant counterparts from
HQ and other global function through my trip," said Lulu Li, associate director, regulatory policy, GRS Mainland China &
Hong Kong. As the China regulatory landscape continues to evolve, it is critical for us to establish an effective communication
mechanism across the various functions and to engage global subject matter experts for review of the significance and impact of
the policy changes in China."
"The trip has also provided me with a great exposure to
the key trade associations that BMS is partnering with and gain first-hand insights of their priorities and the external platforms
we could leverage in policy advocacy in China," Li added.
Important Information For Investors
And Stockholders
This communication does not constitute
an offer to sell or the solicitation of an offer to buy any securities or a solicitation of any vote or approval. It does
not constitute a prospectus or prospectus equivalent document. No offering of securities shall be made except by means of a prospectus
meeting the requirements of Section 10 of the U.S. Securities Act of 1933, as amended.
In connection with the proposed transaction
between Bristol-Myers Squibb Company (“
Bristol-Myers Squibb
”) and Celgene Corporation (“
Celgene
”),
on February 1, 2019, Bristol-Myers Squibb filed with the Securities and Exchange Commission (the “SEC”) a registration
statement on Form S-4, which includes a preliminary joint proxy statement of Bristol-Myers Squibb and Celgene that also constitutes
a preliminary prospectus of Bristol-Myers Squibb, which will be mailed to stockholders of each of Bristol-Myers Squibb and Celgene
once the joint proxy statement/prospectus is in definitive form and the registration statement becomes effective. INVESTORS AND
SECURITY HOLDERS OF
Bristol-Myers Squibb AND Celgene
ARE URGED TO READ THE JOINT
PROXY STATEMENT/PROSPECTUS AND OTHER DOCUMENTS FILED OR THAT WILL BE FILED WITH THE SEC CAREFULLY AND IN THEIR ENTIRETY BECAUSE
THEY CONTAIN IMPORTANT INFORMATION. Investors and security holders may obtain free copies of the registration statement and
the joint proxy statement/prospectus and other documents filed with the SEC by Bristol-Myers Squibb or Celgene through the website
maintained by the SEC at http://www.sec.gov. Copies of the documents filed with the SEC by Bristol-Myers Squibb are available
free of charge on Bristol-Myers Squibb’s internet website at http://www.bms.com under the tab, “Investors” and
under the heading “Financial Reporting” and subheading “SEC Filings” or by contacting Bristol-Myers Squibb’s
Investor Relations Department through https://www.bms.com/investors/investor-contacts.html. Copies of the documents filed
with the SEC by Celgene are available free of charge on Celgene’s internet website at http://www.celgene.com under the tab
“Investors” and under the heading “Financial Information” and subheading “SEC Filings” or by
contacting Celgene’s Investor Relations Department at ir@celgene.com.
Certain Information Regarding Participants
Bristol-Myers Squibb, Celgene, and their
respective directors and executive officers may be considered participants in the solicitation of proxies in connection with the
proposed transaction. Information about the directors and executive officers of Bristol-Myers Squibb is set forth in its
Annual Report on Form 10-K for the year ended December 31, 2017, which was filed with the SEC on February 13, 2018, its proxy statement
for its 2018 annual meeting of stockholders, which was filed with the SEC on March 22, 2018, and its Current Report on Form 8-K,
which was filed with the SEC on August 28, 2018. Information about the directors and executive officers of Celgene is set forth
in its Annual Report on Form 10-K for the year ended December 31, 2017, which was filed with the SEC on February 7, 2018, its proxy
statement for its 2018 annual meeting of stockholders, which was filed with the SEC on April 30, 2018, and its Current Reports
on Form 8-K, which were filed with the SEC on June 1, 2018, June 19, 2018 and November 2, 2018. Other information regarding
the participants in the proxy solicitations and a description of their direct and indirect interests, by security holdings or otherwise,
are contained in the joint proxy statement/prospectus and other relevant materials to be filed with the SEC regarding the proposed
transaction when they become available. You may obtain these documents (when they become available) free of charge through the
website maintained by the SEC at http://www.sec.gov and from Investor Relations at Bristol-Myers Squibb or Celgene as described
above.
Cautionary Statement Regarding Forward-Looking
Statements
This communication contains forward-looking
statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange
Act of 1934, as amended. You can generally identify forward-looking statements by the use of forward-looking terminology
such as “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,”
“explore,” “evaluate,” “intend,” “may,” “might,” “plan,”
“potential,” “predict,” “project,” “seek,” “should,” or “will,”
or the negative thereof or other variations thereon or comparable terminology. These forward-looking statements are only
predictions and involve known and unknown risks and uncertainties, many of which are beyond Bristol-Myers Squibb’s and Celgene’s
control.
Statements in this communication regarding
Bristol-Myers Squibb, Celgene and the combined company that are forward-looking, including projections as to the anticipated benefits
of the proposed transaction, the impact of the proposed transaction on Bristol-Myers Squibb’s and Celgene’s business
and future financial and operating results, the amount and timing of synergies from the proposed transaction, the terms and scope
of the expected financing for the proposed transaction, the aggregate amount of indebtedness of the combined company following
the closing of the proposed transaction, expectations regarding cash flow generation, accretion to non-GAAP earnings per share,
capital structure, debt repayment, adjusted leverage ratio and credit ratings following the closing of the proposed transaction,
Bristol-Myers Squibb’s ability and intent to conduct a share repurchase program and declare future dividend payments, the
combined company’s pipeline, intellectual property protection and R&D spend, the timing and probability of a payment
pursuant to the contingent value right consideration, and the closing date for the proposed transaction, are based on management’s
estimates, assumptions and projections, and are subject to significant uncertainties and other factors, many of which are beyond
Bristol-Myers Squibb’s and Celgene’s control. These factors include, among other things, effects of the continuing
implementation of governmental laws and regulations related to Medicare, Medicaid, Medicaid managed care organizations and entities
under the Public Health Service 340B program, pharmaceutical rebates and reimbursement, market factors, competitive product development
and approvals, pricing controls and pressures (including changes in rules and practices of managed care groups and institutional
and governmental purchasers), economic conditions such as interest rate and currency exchange rate fluctuations, judicial decisions,
claims and concerns that may arise regarding the safety and efficacy of in-line products and product candidates, changes to wholesaler
inventory levels, variability in data provided by third parties, changes in, and interpretation of, governmental regulations and
legislation affecting domestic or foreign operations, including tax obligations, changes to business or tax planning strategies,
difficulties and delays in product development, manufacturing or sales including any potential future recalls, patent positions
and the ultimate outcome of any litigation matter. These factors also include the combined company’s ability to execute successfully
its strategic plans, including its business development strategy, the expiration of patents or data protection on certain products,
including assumptions about the combined company’s ability to retain patent exclusivity of certain products, the impact and
result of governmental investigations, the combined company’s ability to obtain necessary regulatory approvals or obtaining
these without delay, the risk that the combined company’s products prove to be commercially successful or that contractual
milestones will be achieved. Similarly, there are uncertainties relating to a number of other important factors, including: results
of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and
future studies; the content and timing of decisions made by the U.S. FDA and other regulatory authorities, investigational review
boards at clinical trial sites and publication review bodies; the ability to enroll patients in planned clinical trials; unplanned
cash requirements and expenditures; competitive factors; the ability to obtain, maintain and enforce patent and other intellectual
property protection for any product candidates; the ability to maintain key collaborations; and general economic and market conditions.
Additional information concerning these risks, uncertainties and assumptions can be found in Bristol-Myers Squibb’s and Celgene’s
respective filings with the SEC, including the risk factors discussed in Bristol-Myers Squibb’s and Celgene’s most
recent Annual Reports on Form 10-K, as updated by their Quarterly Reports on Form 10-Q and future filings with the SEC.
It should also be noted that projected
financial information for the combined businesses of Bristol-Myers Squibb and Celgene is based on management’s estimates,
assumptions and projections and has not been prepared in conformance with the applicable accounting requirements of Regulation
S-X relating to pro forma financial information, and the required pro forma adjustments have not been applied and are not reflected
therein. None of this information should be considered in isolation from, or as a substitute for, the historical financial statements
of Bristol-Myers Squibb or Celgene. Important risk factors could cause actual future results and other future events to differ
materially from those currently estimated by management, including, but not limited to, the risks that: a condition to the closing
of the proposed acquisition may not be satisfied; a regulatory approval that may be required for the proposed acquisition is delayed,
is not obtained or is obtained subject to conditions that are not anticipated; Bristol-Myers Squibb is unable to achieve the synergies
and value creation contemplated by the proposed acquisition; Bristol-Myers Squibb is unable to promptly and effectively integrate
Celgene’s businesses; management’s time and attention is diverted on transaction related issues; disruption from the
transaction makes it more difficult to maintain business, contractual and operational relationships; the credit ratings of the
combined company declines following the proposed acquisition; legal proceedings are instituted against Bristol-Myers Squibb, Celgene
or the combined company; Bristol-Myers Squibb, Celgene or the combined company is unable to retain key personnel; and the announcement
or the consummation of the proposed acquisition has a negative effect on the market price of the capital stock of Bristol-Myers
Squibb and Celgene or on Bristol-Myers Squibb’s and Celgene’s operating results.
No assurances can be given that any of
the events anticipated by the forward-looking statements will transpire or occur, or if any of them do occur, what impact they
will have on the results of operations, financial condition or cash flows of Bristol-Myers Squibb or Celgene. Should any risks
and uncertainties develop into actual events, these developments could have a material adverse effect on the proposed transaction
and/or Bristol-Myers Squibb or Celgene, Bristol-Myers Squibb’s ability to successfully complete the proposed transaction
and/or realize the expected benefits from the proposed transaction. You are cautioned not to rely on Bristol-Myers Squibb’s
and Celgene’s forward-looking statements. These forward-looking statements are and will be based upon management’s
then-current views and assumptions regarding future events and operating performance, and are applicable only as of the dates of
such statements. Neither Bristol-Myers Squibb nor Celgene assumes any duty to update or revise forward-looking statements, whether
as a result of new information, future events or otherwise, as of any future date.
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