(Updates with stock price information and companies declining to comment.)

Amylin Pharmaceuticals Inc. (AMLN) has rejected an unsolicited $3.5 billion offer from Bristol-Myers Squibb Co. (BMY), made earlier this year, Bloomberg News reported Wednesday, citing two people with knowledge of the matter.

Bristol-Myers had offered $22 a share for the drug maker, but Amylin's board last month turned down the proposal. Amylin stock closed Tuesday at $15.39, and recently traded at $21.50, up $6.11 or 40%.

The people said Bristol-Myers hasn't approached Amylin since then, and said Amylin is talking with several companies about a marketing partnership.

Spokeswomen for the two companies declined comment to Bloomberg.

Bristol-Myers recently traded at $33.71, up 4 cents.

San Diego-based Amylin provides treatments for diabetes and other metabolic disorders.

Full story at: www.bloomberg.com/news/2012-03-28/mylin-said-to-have-spurned-3-5-billion-bristol-myers-bid.html

-Dow Jones Newswires; 212-416-2900

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