jondoeuk
6 minutes ago
Trogocytosis can impact both CAR-T, as well as CAR-NK therapies. Strategies to overcome trogocytosis-induced antigen loss, fratricide and/or cell exhaustion include, pharmacological targeting, modulating CAR affinity, 'armouring,' modulating the signalling domain(s), or using a dual CAR strategy. So
TheHound
9 minutes ago
The Ballad of nowwhat and XRP
Nowwhat, a man of peculiar fame,
Carried a life as odd as his name.
He dreamt of riches, vast and grand,
But fate dealt him a frustrating hand.
XRP, the coin of his dreams,
Promised fortunes, or so it seemed.