DIO Diomed Holdings,

Diomed Holdings, Inc. (AMEX: DIO), a leading developer and marketer of minimally-invasive medical technologies, including its patented EndoVenous Laser Treatment (EVLT(R)) for varicose veins, today announced that it will be presenting an overview of the Company's business at the upcoming Jefferies Life Science Conference at the Mandarin Oriental Hotel in New York on Tuesday, June 27, 2006 at 3:00 p.m. EST. "Diomed is extremely pleased to be included the Jefferies Life Sciences Conference," stated James Wylie, President and Chief Executive Officer for Diomed. "This forum will provide us with the opportunity to showcase Diomed's market leadership position in the field of superficial venous disease treatment." Mr. Wylie will present an overview of the company at 3:00 p.m. EST Monday, June 27, 2006. To take part in this webcast presentation, please login at either http://ir.diomedinc.com or http://www.wsw.com/webcast/jeff11/dio/ . About Jefferies Jefferies, a global investment bank and institutional securities firm, has served growing and mid-sized companies and their investors for over 40 years. Headquartered in New York, with more than 25 offices around the world, Jefferies provides clients with capital markets and financial advisory services, institutional brokerage, securities research and asset management. The firm is a leading provider of trade execution in equity, high yield, convertible and international securities for institutional investors and high net worth individuals. Jefferies & Company, Inc. is the principal operating subsidiary of Jefferies Group, Inc. (NYSE:JEF; www.jefferies.com). About Diomed Diomed develops and commercializes minimal and micro-invasive medical procedures that use its proprietary laser technologies and disposable products. Diomed's EVLT(R) laser vein ablation procedure is used in varicose vein treatments. Diomed also provides photodynamic therapy (PDT) for use in cancer treatments, and dental and general surgical applications. The EVLT(R) procedure and the Company's related products were cleared by the United States FDA in January of 2002. Along with lasers and single-use procedure kits for its EVLT(R) laser vein treatment, the Company provides its customers with state of the art physician training and practice development support. Additional information is available on the Company's website: www.evlt.com. EVLT(R) is a registered trademark of Diomed Inc., Andover, MA.