ANX Mast Therapeutics, Inc.

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

The Board of Directors (the "Board") of ADVENTRX Pharmaceuticals, Inc. (the "Company") has promoted Brandi L. Roberts to Chief Financial Officer and Senior Vice President, effective January 2, 2013. Ms. Roberts, age 39, has served as the Company’s Vice President, Finance and principal accounting officer since March 2011. In connection with her appointment to Chief Financial Officer, Ms. Roberts was also appointed the principal financial officer of the Company, and Patrick Keran, the Company’s President and Chief Operating Officer, shall no longer serve in that role.

Ms. Roberts had also previously served as the Company’s Vice President, Finance from June 2008 to January 2009. Subsequently, from January 2009 to March 2011, she served as vice president, accounting and corporate controller of Alphatec Spine, Inc., the wholly-owned operating subsidiary of Alphatec Holdings, Inc., a medical technology company listed on the NASDAQ Global Select Market, where she was responsible for managing all accounting activities, including SEC reporting and Sarbanes-Oxley Act compliance requirements. From June 2007 to June 2008, Ms. Roberts served as executive director, corporate controller of Artes Medical, Inc., a publicly traded medical technology company, and from September 2005 to June 2007, Ms. Roberts served as director, finance of Stratagene Corporation, a publicly traded life sciences company acquired by Agilent Technologies, Inc. in June 2007. Ms. Roberts’ experience also includes seven years at Pfizer’s laboratories in La Jolla, California (formerly, Agouron), most recently as director, finance, and three years with the public accounting firm of PricewaterhouseCoopers LLP. She is a certified public accountant with the State of California. Ms. Roberts received a B.S. in Business Administration from the University of Arizona and an M.B.A. from the University of San Diego.

In connection with the change in Ms. Roberts’ role with the Company, her annual base salary has increased to $250,000 and she has received a stock option award to purchase up to 75,750 shares of the Company’s common stock at an exercise price of $0.59 per share, which was the closing sale price of the Company’s common stock on the NYSE MKT equities market on January 2, 2013, the option grant date. The option will vest and become exercisable in 48 substantially equal monthly installments over the 48 months following the grant date, subject to Ms. Roberts’ continued service with the Company. The option award was granted under the Company’s Amended and Restated 2008 Omnibus Incentive Plan (the "2008 Plan") and has a 10-year term, unless earlier terminated in connection with termination of employment, retirement, death or disability. In the event of a change of control of the Company, the option award will vest and become exercisable in full if the successor company does not assume or substitute for the option or the successor company assumes or substitutes for the option award but Ms. Roberts’ employment is subsequently terminated without "cause" or for "good reason" (each as defined in the 2008 Plan) within 24 months after the change in control. Ms. Roberts also participates in the Company’s Change in Control Severance Plan, which was adopted by the Compensation Committee of the Board on December 6, 2012. A description of the Change in Control Severance Plan is contained in the Company’s Current Report on Form 8-K filed on December 7, 2012 and is incorporated herein by reference. The Compensation Committee assigned to Ms. Roberts a nine-month benefit period under the Change in Control Severance Plan.