22nd Century’s Fox Business Network Appearance Rescheduled

“Varney & Co” Segment Moved to Wednesday, April 29, 2015 at 12:50 p.m. EDT

22nd Century Group, Inc. (NYSE MKT: XXII), a leader in very low nicotine tobacco technology and tobacco harm reduction, today announced that due to the extensive coverage of the ongoing Baltimore unrest, the previously announced interview of 22nd Century’s President and Chief Executive Officer, Henry Sicignano III, by Stuart Varney of Fox Business’ “Varney & Co” has been moved from today to Wednesday, April 29, 2015 at 12:50 p.m. EDT.

Revised Varney & Co. with Stuart Varney programming details are as follows:

Date: Wednesday, April 29, 2015 Start Time: 12:50 p.m. EDT Live TV: Fox Business Network

About 22nd Century Group, Inc.

22nd Century Group is a plant biotechnology company focused on technology which allows it to increase or decrease the level of nicotine in tobacco plants through genetic engineering and plant breeding. The Company’s mission is to reduce the harm caused by smoking. 22nd Century owns or exclusively controls 128 issued patents plus an additional 52 pending patent applications in 96 countries. The Company’s strong IP position led to a licensing agreement with British American Tobacco (“BAT”), the world’s second largest tobacco company. Visit www.xxiicentury.com for more information.

Investor Relations:IRTH CommunicationsAndrew Haag, 866-976-4784xxii@irthcommunications.comorRedington, Inc.Tom Redington, 203-222-7399

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