Aurora TX, powered by
Microfluidic Modulation Spectroscopy (MMS), fully characterizes the
structure and stability of RNA, proteins, peptides, and other
biomolecules at the touch of a button, including thermal ramping to
unlock a greater wealth of insights than ever before.
BOXBOROUGH, Mass., May 13, 2024 /PRNewswire/ -- RedShiftBio, a
leader in innovative biophysical characterization and bioprocess
analytical solutions, proudly announces the launch of Aurora TX at The Protein & Antibody
Engineering Summit (PEGS), kicking off on May 13, 2024, in Boston, MA. Aurora
TX is the company's latest, most advanced instrument
featuring ground-breaking MMS technology, and sets a new standard
in biomolecular analysis by providing ultra-sensitive,
ultra-precise measurements of biomolecule structure and stability,
now enhanced with the addition of thermal ramping capability.
Aurora TX
characterizes structure and stability of RNA, proteins, and more,
along with new thermal ramping capability.
MMS technology, the cornerstone of Aurora TX, provides background-subtracted
measurements of a wide range of biomolecules in the formulation of
interest and in concentrations ranging from 0.1 mg/mL to >200
mg/mL. This level of accuracy and versatility, coupled with an
easy, automated workflow, utilization of 96-well plates, and fully
integrated delta analytical software addresses the
limitations of existing technologies such as CD and FTIR. By
offering ultra-sensitive and highly reproducible structural
measurements along with a full interpretation of results,
Aurora TX empowers researchers to
delve deeper into the characterization of nucleic acids, proteins,
and other biomolecules without the need for spectroscopy expertise.
With the ability to compare higher-order structures, stability
profiles, and similarity profiles, Aurora
TX facilitates informed decision-making across various
stages of biopharmaceutical drug development, from discovery to
quality control.
One of the most noteworthy advancements of Aurora TX is its growing application in RNA
analysis. With its exceptional sensitivity enabled by MMS,
Aurora TX is ideal for nucleic
acid characterization. Researchers can use Aurora TX to detect structural changes to RNA
due to sequence modifications, formulation changes, and thermal
stress. Even structural differences in the payload upon LNP
encapsulation and RNA-to-LNP ratio are now measurable, all with
walk-away automation.
The integration of thermal ramping in Aurora TX adds a new dimension to biomolecular
analysis by enabling researchers to induce high-resolution
temperature stress, facilitating the detection of structural
changes with precision and repeatability. This feature streamlines
the analysis process, saving time and resources for researchers
engaged in drug discovery and development.
Tom O'Lenic, CEO of RedShiftBio,
commented on the launch, stating, "Aurora
TX represents a significant milestone in biophysical
characterization technology. With its unparalleled sensitivity,
precision, and versatility, Aurora
TX empowers researchers to unlock deeper insights into
biomolecular structures, presenting a pioneering strategy for RNA
analysis and paving the way for advancements in the development of
RNA and protein therapeutics."
Key features of Aurora TX
include:
- Ultra-sensitive and highly reproducible structural
measurements
- Wide applicability across many therapeutic modalities
- Thermal ramping capability for controlled temperature
stress/stability assessments
- Walk-away automation with multiple measurements in a single
analysis
- Robust delta software for simplified data
collection and interpretation
- New, streamlined optional buffer station that enhances
throughput by integrating up to 8 buffers directly into the system
during analysis
For more information about Aurora
TX and RedShiftBio's innovative solutions, visit
www.redshiftbio.com/products/aurora-tx
About RedShift
BioAnalytics
RedShiftBio® is a
forward-thinking technology company providing novel life science
analytical platforms, reagents, software, and services to leading
biopharmaceutical companies and research laboratories. The company
has developed a powerful new analytical technique, Microfluidic
Modulation Spectroscopy (MMS), that provides in-depth biomolecule
structural information in a single automated analysis. RedShiftBio
also offers the HaLCon Analyzer, a fit-for-purpose protein analyzer
designed to provide easy and accurate protein titer measurements at
the point of need. RedShiftBio is headquartered in Boxborough, Massachusetts.
For further information, please contact:
Marisa Pisani,
mpisani@redshiftbio.com
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SOURCE RedShift BioAnalytics