Item 1.01 Entry into a Material Definitive Agreement.
On January 3, 2022, Enzo Biochem, Inc. (the “Company”)
entered into a cooperation agreement (the “Agreement”) with Bradley L. Radoff and certain affiliated entities (collectively,
the “Radoff Group”). The Radoff Group beneficially owned approximately 8.9% of the outstanding shares of common stock of the
Company (“Common Stock”) as of January 3, 2022.
Pursuant to the Agreement, on January 3, 2022,
the Board of Directors of the Company (the “Board”) appointed each of Hamid Erfanian and Bradley L. Radoff (collectively,
the “Appointees”) to the Board to fill the vacancies described in Item 5.02 hereof, with each to serve until the Company’s
next annual meeting of shareholders or until his earlier death, resignation, disqualification or removal.
Under the Agreement, so long as the Radoff Group
has not breached the Agreement, the Company agreed to nominate the Appointees for election to the Board at the Company’s 2021 annual
meeting of shareholders (the “2021 Annual Meeting”). Further, pursuant to the Agreement, the Radoff Group has agreed, until
the earlier of (x) the date that is thirty (30) calendar days prior to the deadline for the submission of shareholder nominations for
the Company’s 2022 annual meeting of shareholders pursuant to the Company’s Amended and Restated Bylaws, as amended, or (y)
the date that is one hundred twenty (120) calendar days prior to the first anniversary of the 2021 Annual Meeting (the “Standstill
Period”), not to take the following actions, among others: (1) solicit proxies, (2) join any “group” or voting arrangement,
(3) submit nominations for a contested election, (4) propose or publicly comment on any extraordinary transactions involving the Company,
(5) acquire, announce an intention to acquire, offer or propose to acquire, or agree to acquire, directly or indirectly, by purchase or
otherwise, any security of the Company that would result in the Radoff Group beneficially owning 9.9% or more of the then outstanding
Common Stock, (6) except as expressly provided within the Agreement, grant any proxy, consent or other authority to vote with respect
to any matter or (7) encourage or support any other stockholder to take any of the foregoing actions. If any of the Radoff Appointees
is unable to serve as a director, resigns as a director or is removed as a director during the Standstill Period, the Radoff Group may
recommend another individual for appointment to the Board who meets certain criteria, including qualifying as “independent”
under the rules of the New York Stock Exchange, among others.
In addition, the Company will seek the approval
of the Company’s shareholders at the 2021 Annual Meeting of an amendment to the Company’s Certificate of Incorporation, as
amended, to declassify the structure of the Board (the “Declassification Proposal”) such that directors standing for election
at and subsequent to the 2021 Annual Meeting shall stand for election to one-year term. Pursuant to the Agreement, the Radoff Group has
agreed to appear in person or by proxy at the 2021 Annual Meeting and all subsequent stockholder meetings during the Standstill Period
and to vote all of the Common Stock beneficially owned by it in accordance with the Board’s recommendations with respect to (1)
nominees to the Board, (2) the Declassification Proposal or (3) any other matter at each such subsequent stockholder meeting, subject
to certain exceptions.
In addition, the Company and the Radoff Group have
agreed that the Company will reimburse the Radoff Group for its reasonable documented expenses, including legal fees, up to $150,000 incurred
in connection with the Agreement and all related matters.
The Agreement contains various other representations
and warranties, obligations and provisions applicable to the Company and the Radoff Group.
The foregoing summary of the Agreement does not
purport to be complete and is qualified in its entirety by reference to the full text of the Agreement, which is filed as Exhibit 10.1
to this Current Report on Form 8-K.