EXPLANATORY NOTE
This Amendment No. 23 hereby amends and supplements the statement of beneficial ownership on Schedule 13D, relating to the common stock,
$0.001 par value per share (the Issuer Common Stock), of Lexicon Pharmaceuticals, Inc., a Delaware corporation (the Issuer or Lexicon), initially filed on June 27, 2007, as amended by
Amendment No. 1 thereto filed on August 24, 2007, Amendment No. 2 thereto filed on August 29, 2007, Amendment No. 3 thereto filed on October 8, 2009, Amendment No. 4 thereto filed on October 15, 2009,
Amendment No. 5 thereto filed on March 19, 2010, Amendment No. 6 thereto filed on August 15, 2011, Amendment No. 7 thereto filed on November 14, 2011, Amendment No. 8 thereto filed on December 27, 2011,
Amendment No. 9 thereto filed on February 24, 2012, Amendment No. 10 thereto filed on April 10, 2012, Amendment No. 11 thereto filed on October 26, 2012, Amendment No. 12 thereto filed on November 26, 2014,
Amendment No. 13 thereto filed on June 4, 2018, Amendment No. 14 thereto filed on June 29, 2018, Amendment No. 15 thereto filed on December 16, 2020, Amendment No. 16 thereto filed on January 5, 2021,
Amendment No. 17 thereto filed on January 21, 2021, Amendment No. 18 thereto filed on August 1, 2022, Amendment No. 19 thereto filed on August 9, 2022, Amendment No. 20 thereto filed on June 6, 2023, Amendment
No. 21 thereto filed on March 13, 2024 and Amendment No. 22 thereto filed on May 14, 2024 (as so amended, the Statement). All capitalized terms not otherwise defined herein have the meaning assigned to
them in the Statement.
On July 25, 2024, in connection with a reorganization (the Reorganization), Invus Global
Management, LLC replaced the Geneva branch of Artal International S.C.A. as the managing member of Invus Public Equities Advisors, LLC and Invus Global Management, LLC replaced Artal International S.C.A. as the managing member of Invus Advisors,
L.L.C. As a result of the Reorganization, Invus Global Management, LLC as the managing member of Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C.; Siren, L.L.C. as the managing member of Invus Global Management, LLC; and
Mr. Raymond Debbane as the managing member of Siren, L.L.C. may now be deemed to beneficially own the securities beneficially owned by Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C. Artal International S.C.A., Artal
International Management S.A., Artal Group S.A., Westend S.A., Stichting Administratiekantoor Westend and Mr. Amaury Wittouck are no longer deemed to beneficially own the securities beneficially owned by Invus Public Equities Advisors, LLC and
Invus Advisors, L.L.C. See Item 2.
Item 2. Identity and Background
Item 2 of the Statement is hereby amended and restated in its entirety as follows:
This statement is being filed jointly by Invus, L.P., a Bermuda limited partnership, Invus Advisors, L.L.C., a Delaware limited liability
company, Invus Public Equities, L.P., a Bermuda limited partnership, Invus Public Equities Advisors, LLC, a Delaware limited liability company, Invus US Partners LLC, a Delaware limited liability company, Invus Global Management, LLC, a Delaware
limited liability company, Siren, L.L.C., a Delaware limited liability company, Ulys, L.L.C., a Delaware limited liability company, Mr. Raymond Debbane, a citizen of Panama, Artal International S.C.A., a Luxembourg limited partnership, Artal
International Management S.A., a Luxembourg société anonyme, Artal Group S.A., a Luxembourg société anonyme, Westend S.A., a Luxembourg société anonyme (Westend), Stichting
Administratiekantoor Westend, a Netherlands foundation (the Stichting), and Mr. Amaury Wittouck, a citizen of Belgium (collectively, the Reporting Persons).
The address of the principal place of business and principal office of Invus, L.P., Invus Public Equities, L.P., Invus US Partners LLC, Invus
Global Management, LLC, Siren, L.L.C., Invus Advisors, L.L.C., Invus Public Equities Advisors, LLC and Ulys, L.L.C. is c/o The Invus Group, LLC, 750 Lexington Avenue, 30th Floor, New York, NY 10022. The business address for Mr. Debbane is c/o
The Invus Group, LLC, 750 Lexington Avenue, 30th Floor, New York, NY 10022. The address of the principal place of business and principal office of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend and
Mr. Amaury Wittouck is 44, Rue de la Vallée, L-2661, Luxembourg, Luxembourg. The address of the principal place of business and principal office of the Stichting is Claude Debussylaan,
46, 1082 MD Amsterdam, The Netherlands.
In connection with the Reorganization, Invus Global Management, LLC replaced the Geneva branch of
Artal International as the managing member of Invus Public Equities Advisors, LLC and Invus Global Management, LLC replaced Artal International S.C.A. as the managing member of Invus Advisors, L.L.C.
Invus, L.P. is controlled by Invus Advisors, L.L.C. and Invus Public Equities, L.P. is controlled by Invus Public Equities Advisors, LLC. Each
of Invus Advisors, L.L.C. and Invus Public Equities Advisors, LLC is controlled by Invus Global Management, LLC. Invus Global Management, LLC is controlled by Siren, L.L.C. Siren, L.L.C. is controlled by Mr. Raymond Debbane.
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