New Analyses of Sotagliflozin to Be Presented at the American College of Cardiology’s 72nd Annual Scientific Session Together With World Heart Federation’s World Congress of Cardiology
February 20 2023 - 8:00AM
Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), today announced the
upcoming presentation of new analyses of results from the
SOLOIST-WHF Phase 3 outcomes study of its investigational
sotagliflozin product at the American College of Cardiology’s 72nd
Annual Scientific Session Together With World Heart Federation’s
World Congress of Cardiology in New Orleans, Louisiana.
The following analyses of sotagliflozin have
been selected for presentation:
-
“Time to Clinical Benefit of Sotagliflozin in People with Worsening
Heart Failure in SOLOIST-WHF”, a moderated poster presentation on
Saturday, March 4th at 11:00 am CT
-
“Effects of SGLT 1-2 Inhibitor Sotagliflozin on Symptoms, Physical
Limitations and Quality of Life in Patients with Worsening Heart
Failure: Results from the SOLOIST Trial”, a moderated poster
presentation on Saturday, March 4th at 10:15 am CT
-
“Levels of Soluble Urokinase Plasminogen Activator Receptor and
Heart Failure Outcomes in Patients with Type 2 Diabetes and
Worsening Heart Failure Treated with Sotagliflozin, a Dual SGLT 1
and SGLT 2 Inhibitor”, a poster presentation on Sunday, March 5th
at 2:45 pm CT
-
“Sotagliflozin, a Dual SGLT 1 and 2 Inhibitor, Modulated Expression
of Atheroprotective Proteins during Inflammation Compared with
Empagliflozin”, a moderated poster presentation on Monday, March
6th at 10:30 am CT
About the SOLOIST-WHF Study
SOLOIST-WHF was a multi-center, randomized,
double-blinded, placebo-controlled Phase 3 study evaluating the
cardiovascular efficacy of sotagliflozin versus placebo when added
to standard of care in 1,222 patients with type 2 diabetes who had
recently been hospitalized for worsening heart failure. The primary
endpoint was the total number of events comprised of deaths from
cardiovascular causes, hospitalizations for heart failure, and
urgent visits for heart failure in patients treated with
sotagliflozin compared with placebo.
SOLOIST-WHF achieved its primary endpoint, with
overall tolerability similar to placebo. Results were presented at
the Late-Breaking Science Session of the American Heart Association
(AHA) Scientific Sessions 2020 and simultaneously published in The
New England Journal of Medicine (NEJM) in an article titled:
“Sotagliflozin in Patients with Diabetes and Recent Worsening Heart
Failure” which may be accessed at www.nejm.org.
About Sotagliflozin
Discovered using Lexicon’s unique approach to
gene science, sotagliflozin is an investigational oral dual
inhibitor of two proteins responsible for glucose regulation known
as sodium-glucose co-transporter types 1 and 2 (SGLT1 and SGLT2).
SGLT1 is responsible for glucose absorption in the gastrointestinal
tract, and SGLT2 is responsible for glucose reabsorption by the
kidney. Sotagliflozin has been studied in multiple patient
populations encompassing heart failure, type 1 and type 2 diabetes,
and chronic kidney disease in fourteen Phase 3 clinical studies
involving approximately 20,000 patients.
About Lexicon
Pharmaceuticals
Lexicon is a biopharmaceutical company with a
mission of pioneering medicines that transform patients’ lives.
Through its Genome5000™ program, Lexicon scientists studied the
role and function of nearly 5,000 genes and identified more than
100 protein targets with significant therapeutic potential in a
range of diseases. Through the precise targeting of these proteins,
Lexicon is pioneering the discovery and development of innovative
medicines to safely and effectively treat disease. Lexicon advanced
one of these medicines to market and has a pipeline of promising
drug candidates in discovery and clinical and preclinical
development in heart failure, neuropathic pain, diabetes and
metabolism and other indications. For additional information,
please visit www.lexpharma.com.
Safe Harbor Statement
This press release contains “forward-looking
statements,” including statements relating to the research and
clinical development of, regulatory filings for, and potential
therapeutic and commercial potential of sotagliflozin. In addition,
this press release also contains forward looking statements
relating to Lexicon’s financial position and long-term outlook on
its business, growth and future operating results, discovery and
development of products, strategic alliances and intellectual
property, as well as other matters that are not historical facts or
information. All forward-looking statements are based on
management’s current assumptions and expectations and involve
risks, uncertainties and other important factors, specifically
including Lexicon’s ability to meet its capital requirements,
successfully conduct preclinical and clinical development and
obtain necessary regulatory approvals of sotagliflozin, LX9211 and
its other potential drug candidates on its anticipated timelines,
successfully commercialize any products for which it obtains
regulatory approval, achieve its operational objectives, obtain
patent protection for its discoveries and establish strategic
alliances, as well as additional factors relating to manufacturing,
intellectual property rights, and the therapeutic or commercial
value of its drug candidates. Any of these risks, uncertainties and
other factors may cause Lexicon’s actual results to be materially
different from any future results expressed or implied by such
forward-looking statements. Information identifying such important
factors is contained under “Risk Factors” in Lexicon’s annual
report on Form 10-K for the year ended December 31, 2021, as filed
with the Securities and Exchange Commission. Lexicon undertakes no
obligation to update or revise any such forward-looking statements,
whether as a result of new information, future events or
otherwise.
For Investor Inquiries:
Carrie SiragusaLexicon Pharmaceuticals,
Inc.csiragusa@lexpharma.com
For Media Inquiries:
Alina KolomeyerLexicon Pharmaceuticals,
Inc.akolomeyer@lexpharma.com
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