FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Ianelli Christopher 2. Issuer Name and Ticker or Trading Symbol iSpecimen Inc. [ ISPC ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)__X__ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
President & CEO
(Last)          (First)          (Middle)
450 BEDFORD STREET
3. Date of Earliest Transaction (MM/DD/YYYY)
2/22/2022
(Street)
LEXINGTON, MA 02420
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock  2/22/2022    M(1)    3099  A $1.00 (2) 398540  D   
Common Stock  2/23/2022    M(1)    48106  A $1.00 (2) 446646  D   

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Option  $1.00  2/22/2022    M        3099    (3) 1/31/2029  Common Stock  3099  $0  49515 (5) D   
Option  $1.00  2/23/2022    M        48106    (4) 7/12/2029  Common Stock  48106  $0  1409 (5) D   

Explanation of Responses:
(1)  Acquisition of shares of common stock by the Reporting Person upon the exercise of stock options.
(2)  Represents the $1.00 exercise price per share of the stock options exercised, which was paid by the Reporting Person upon exercise of such stock options.
(3)  Represents a portion of the stock options granted to the Reporting Person on April 26, 2019, pursuant to the Issuer's 2013 Stock Incentive Plan, which were fully vested on November 30, 2021.
(4)  Represents the stock options granted to the Reporting Person on July 13, 2019, pursuant to the Issuer's 2010 Stock Incentive Plan, which were fully vested on July 14, 2019.
(5)  Represents remaining granted stock options across all grants.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Ianelli Christopher
450 BEDFORD STREET
LEXINGTON, MA 02420
X
President & CEO

Signatures
/s/ Christopher Ianelli 2/24/2022
**Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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