- Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Expires: February 28, 2011 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Prospect Venture Partners III L P

2. Date of Event Requiring Statement (MM/DD/YYYY) 11/10/2010

3. Issuer Name and Ticker or Trading Symbol

COMPLETE GENOMICS INC [GNOM]

(Last) (First) (Middle)

C/O PROSPECT VENTURE PARTNERS, 435 TASSO STREET, SUITE 200

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director ___ X ___ 10% Owner
_____ Officer (give title below) _____ Other (specify below)

(Street)

PALO ALTO, CA 94301

(City) (State) (Zip)

5. If Amendment, Date Original Filed (MM/DD/YYYY)

6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stcok, $0.001 par value	405542	I	See Footnote (4)

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Series B Preferred Stock ⁽¹⁾	⁽²⁾	⁽³⁾	Common Stock	601248	$0.00	I	See Footnote ⁽⁴⁾
Series C Preferred Stock ⁽⁵⁾	⁽²⁾	⁽³⁾	Common Stock	160552	$0.00	I	See Footnote ⁽⁴⁾
Series D Preferred Stock ⁽⁶⁾	⁽²⁾	⁽³⁾	Common Stock	674426	$0.00	I	See Footnote ⁽⁴⁾
Series E Preferred Stock ⁽⁶⁾	⁽²⁾	⁽³⁾	Common Stock	807760	$0.00	I	See Footnote ⁽⁴⁾
Warrant to Purchase Common Stock	⁽⁷⁾	4/12/2015	Common Stock	133938	$1.50	I	See Footnote ⁽⁴⁾
Warrant to Purchase Common Stock	⁽⁷⁾	6/22/2015	Common Stock	51959	$1.50	I	See Footnote ⁽⁴⁾
Warrant to Purchase Series D Preferred Stock ⁽⁶⁾	⁽⁷⁾	2/13/2014	Common Stock	29343	$7.56	I	See Footnote ⁽⁴⁾
Warrant to Purchase Series D Preferred Stock ⁽⁶⁾	⁽⁷⁾	4/6/2014	Common Stock	31299	$7.56	I	See Footnote ⁽⁴⁾
Warrant to Purchase Series D Preferred Stock ⁽⁶⁾	⁽⁷⁾	6/12/2014	Common Stock	10240	$7.56	I	See Footnote ⁽⁴⁾
Warrant to Purchase Series D Preferred Stock ⁽⁶⁾	⁽⁷⁾	8/5/2014	Common Stock	990	$7.56	I	See Footnote ⁽⁴⁾

Explanation of Responses:
( 1)	Each share of Series B Preferred Stock will automatically convert into common stock upon the closing of the Issuer's initial public offering. Shares are reported on an "as converted" basis giving effect to the 5.926613 conversion ratio applicable to such shares.
( 2)	The securities are immediately convertible.
( 3)	The expiration date is not relevant to the conversion of these securities.
( 4)	The shares are owned by Prospect Venture Partners III, L.P. ("PVP III"). Prospect Management Co. III, L.L.C. ("PMC III") serves as the general partner of PVP III and possesses sole voting and investment control over the shares owned by PVP III and may be deemed to have indirect beneficial ownership of the shares held by PVP III. PMC III however owns no securities of the Issuer directly. The Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of his proportionate pecuniary interest therein.
( 5)	Each share of Series C Preferred Stock will automatically convert into common stock upon the closing of the Issuer's initial public offering. Shares are reported on an "as converted" basis giving effect to the 8.241076 conversion ratio applicable to such shares.
( 6)	Each share of Series D and Series E Preferred Stock will automatically convert on a 1-for-1 basis into common stock upon the closing of the Issuer's initial public offering.
( 7)	The warrant is immediately exercisable.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Prospect Venture Partners III L P C/O PROSPECT VENTURE PARTNERS 435 TASSO STREET, SUITE 200 PALO ALTO, CA 94301		X
Prospect Management Co. III, L.L.C. 435 TASSO STREET SUITE 200 PALO ALTO, CA 94301		X

Signatures
/s/ Managing Director, Prospect Management Co. III LLC, its General Partner, PROSPECT VENTURE PARTNERS III. L.P.		11/10/2010
^** Signature of Reporting Person		Date
/s/ Managing Director, PROSPECT MANAGEMENT CO. II, LLC		11/10/2010
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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