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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 10-Q
(Mark One)
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☒ |
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the quarterly period ended September 30, 2023
OR
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☐ |
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the transition period from ___________________ to ___________________
Commission File Number: 001-40499
Cyteir Therapeutics, Inc.
(Exact Name of Registrant as Specified in its Charter)
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Delaware |
45-5429901 |
(State or other jurisdiction of incorporation or organization) |
(I.R.S. Employer Identification No.) |
99 Hayden Ave., Building B, Suite 450 Lexington, MA |
02421 |
(Address of principal executive offices) |
(Zip Code) |
Registrant’s telephone number, including area code: 857-285-4140
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class |
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Trading Symbol(s) |
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Name of each exchange on which registered |
Common Stock, par value $0.001 per share |
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CYT |
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Nasdaq Global Select Market |
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
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Large accelerated filer |
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☐ |
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Accelerated filer |
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☐ |
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Non-accelerated filer |
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☒ |
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Smaller reporting company |
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☒ |
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Emerging growth company |
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☒ |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
As of November 2, 2023, the registrant had 35,998,068 shares of common stock, $0.001 par value per share, outstanding.
Table of Contents
i
Cautionary Note Regarding Forward-Looking Statements
This Quarterly Report on Form 10-Q contains forward-looking statements with respect to, among other things, our operations and financial performance. All statements other than statements of historical facts contained in this Quarterly Report on Form 10-Q, including statements regarding our future results of operations and financial position, business strategy and plans and our objectives for future operations, are forward-looking statements. The words “believe,” “may,” “will,” "estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “could,” “target,” “predict,” “seek” and similar expressions are intended to identify forward-looking statements. We include forward-looking information in our discussion of the following, among other topics, the planned timing of our liquidation and dissolution, our intent to wind down our clinical trial of CYT-0851, and our estimates regarding our cash runway, expenses, and capital requirements.
These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those referenced in the section titled “Risk Factors,” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022, filed with the U.S. Securities and Exchange Commission on March 23, 2023, which could cause actual results to differ materially. Moreover, we operate in a very competitive and rapidly changing environment and new risks emerge from time to time. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in or implied by any forward-looking statements we may make. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed in this Quarterly Report on Form 10-Q may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements.
The forward-looking statements included in this Quarterly Report on Form 10-Q are made only as of the date of this report. You should not rely upon forward-looking statements as predictions of future events. We cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward-looking statements will be achieved or occur. Moreover, neither we nor any other person assumes responsibility for the accuracy and completeness of the forward-looking statements. We undertake no obligation to update publicly any forward-looking statements for any reason after the date of this Quarterly Report on Form 10-Q to conform these statements to actual results or reflect interim developments, except as required by law.
Some of the key factors that could cause actual results to differ include that:
To the extent our liabilities, other obligations and expenses or claims against us are higher than we currently anticipate or larger contingency reserves are established, the amount available for distribution to our stockholders will be diminished.
We may not be successful in selling our clinical assets and programs, which would limit the amount of cash available to distribute to our stockholders.
The exact amount or timing of any liquidating distributions to our stockholders under our plan of liquidation and dissolution is uncertain.
If we fail to create an adequate contingency reserve for payment of our expenses and liabilities, any stockholder receiving liquidating distributions could be held liable for payment to our creditors of their pro rata share of amounts owed to creditors in excess of the contingency reserve, up to the amount actually distributed to such stockholder in dissolution.
Our stock transfer books will be closed at the close of business on the date we file the Certificate of Dissolution with the Delaware Secretary of State, after which it will not be possible for stockholders to publicly trade our stock.
Our common stock may be delisted from Nasdaq and may result in limitation on future trading of our common stock prior to our liquidation and dissolution.
We may be unable to retain employees, consultants and other resources to carry out our liquidation and dissolution.
Our Board of Directors may abandon, modify, or delay implementation of our plan of liquidation and dissolution, even after stockholder approval.
1
PART I—FINANCIAL INFORMATION
Item 1. Financial Statements.
CYTEIR THERAPEUTICS, INC.
Condensed consolidated balance sheets
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(in thousands, except share and per share amounts) (unaudited) |
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September 30, 2023 |
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December 31, 2022 |
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Assets |
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Current assets: |
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Cash and cash equivalents |
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$ |
129,242 |
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$ |
147,120 |
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Prepaid expenses and other current assets |
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1,401 |
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2,089 |
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Total current assets |
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$ |
130,643 |
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$ |
149,209 |
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Property and equipment, net |
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105 |
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1,699 |
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Other assets |
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261 |
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2,324 |
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Total assets |
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$ |
131,009 |
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$ |
153,232 |
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Liabilities and stockholders’ equity |
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Current liabilities: |
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Accounts payable |
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$ |
508 |
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$ |
1,128 |
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Accrued expenses and other current liabilities |
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5,461 |
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4,187 |
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Total current liabilities |
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$ |
5,969 |
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$ |
5,315 |
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Other long term liabilities |
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9 |
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1,631 |
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Total liabilities |
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$ |
5,978 |
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$ |
6,946 |
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Commitments and contingencies (Note 10) |
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Stockholders’ equity: |
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Preferred stock, $0.001 par value: 40,000,000 shares authorized as of September 30, 2023 and December 31, 2022; no shares issued and outstanding as of September 30, 2023 and December 31, 2022 |
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— |
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— |
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Common stock, $0.001 par value: 280,000,000 shares authorized as of September 30, 2023 and December 31, 2022; 36,091,075 and 35,575,694 shares issued as of September 30, 2023 and December 31, 2022, respectively; 36,083,742 and 35,516,249 shares outstanding as of September 30, 2023 and December 31, 2022, respectively |
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35 |
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35 |
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Additional paid-in capital |
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287,532 |
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284,365 |
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Accumulated deficit |
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(162,536 |
) |
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(138,114 |
) |
Total stockholders’ equity |
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125,031 |
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146,286 |
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Total liabilities and stockholders’ equity |
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$ |
131,009 |
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$ |
153,232 |
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See accompanying notes to condensed consolidated financial statements.
2
CYTEIR THERAPEUTICS, INC.
Condensed consolidated statements of operations
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Three Months Ended September 30, |
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Nine Months Ended September 30, |
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(in thousands, except share and per share amounts) (unaudited) |
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2023 |
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2022 |
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2023 |
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2022 |
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Operating expenses: |
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Research and development |
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$ |
2,676 |
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$ |
8,272 |
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$ |
17,391 |
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$ |
27,154 |
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General and administrative |
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2,495 |
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3,487 |
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10,809 |
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10,963 |
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Total operating expenses |
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5,171 |
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11,759 |
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28,200 |
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38,117 |
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Loss from operations |
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(5,171 |
) |
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(11,759 |
) |
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(28,200 |
) |
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(38,117 |
) |
Other income (expense): |
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Interest income |
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1,639 |
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714 |
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4,385 |
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849 |
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Loss on disposal of property and equipment |
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- |
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- |
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(925 |
) |
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- |
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Gain on lease terminations and modification |
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- |
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- |
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318 |
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- |
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Total other income (expense) |
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1,639 |
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714 |
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3,778 |
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849 |
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Net loss |
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$ |
(3,532 |
) |
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$ |
(11,045 |
) |
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$ |
(24,422 |
) |
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$ |
(37,268 |
) |
Net loss per share—basic and diluted |
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$ |
(0.10 |
) |
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$ |
(0.31 |
) |
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$ |
(0.68 |
) |
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$ |
(1.06 |
) |
Weighted-average common stock outstanding—basic and diluted |
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36,030,474 |
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35,329,137 |
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35,647,202 |
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35,283,454 |
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See accompanying notes to condensed consolidated financial statements.
3
CYTEIR THERAPEUTICS, INC.
Condensed consolidated statements of stockholders’ equity
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Common stock |
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(in thousands, except share and per share amounts) (unaudited) |
Shares |
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Amount |
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Additional paid-in capital |
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Accumulated deficit |
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Total stockholders’ equity |
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Balance At December 31, 2021 |
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35,219,834 |
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$ |
35 |
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|
$ |
279,310 |
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$ |
(92,053 |
) |
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$ |
187,292 |
|
Exercise of common stock options |
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19,575 |
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— |
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19 |
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— |
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19 |
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Vesting of early exercised options |
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32,605 |
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— |
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39 |
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— |
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39 |
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Stock-based compensation expense |
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— |
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— |
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1,255 |
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— |
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1,255 |
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Net loss |
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— |
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— |
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— |
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(14,102 |
) |
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(14,102 |
) |
Balance At March 31, 2022 |
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35,272,014 |
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|
$ |
35 |
|
|
$ |
280,623 |
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|
$ |
(106,155 |
) |
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$ |
174,503 |
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Exercise of common stock options |
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4,398 |
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|
|
— |
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|
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5 |
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|
|
— |
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|
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5 |
|
Vesting of early exercised options |
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26,732 |
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|
|
— |
|
|
|
32 |
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|
|
— |
|
|
|
32 |
|
Stock-based compensation expense |
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— |
|
|
|
— |
|
|
|
1,365 |
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|
|
— |
|
|
|
1,365 |
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Net loss |
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— |
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— |
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— |
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|
|
(12,121 |
) |
|
|
(12,121 |
) |
Balance At June 30, 2022 |
|
35,303,144 |
|
|
$ |
35 |
|
|
$ |
282,025 |
|
|
$ |
(118,276 |
) |
|
$ |
163,784 |
|
Exercise of common stock options |
|
6,112 |
|
|
|
— |
|
|
|
7 |
|
|
|
— |
|
|
|
7 |
|
Vesting of early exercised options |
|
25,511 |
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|
|
— |
|
|
|
30 |
|
|
|
— |
|
|
|
30 |
|
Issuance of common stock under ESPP |
|
19,374 |
|
|
|
— |
|
|
|
64 |
|
|
|
— |
|
|
|
64 |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
1,193 |
|
|
|
— |
|
|
|
1,193 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(11,045 |
) |
|
|
(11,045 |
) |
Balance At September 30, 2022 |
|
35,354,141 |
|
|
$ |
35 |
|
|
$ |
283,319 |
|
|
$ |
(129,321 |
) |
|
$ |
154,033 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common stock |
|
|
|
|
|
|
|
|
|
|
(in thousands, except share and per share amounts) (unaudited) |
Shares |
|
|
Amount |
|
|
Additional paid-in capital |
|
|
Accumulated deficit |
|
|
Total stockholders’ equity |
|
Balance At December 31, 2022 |
|
35,516,249 |
|
|
$ |
35 |
|
|
$ |
284,365 |
|
|
$ |
(138,114 |
) |
|
$ |
146,286 |
|
Exercise of common stock options |
|
41,588 |
|
|
|
— |
|
|
|
42 |
|
|
|
— |
|
|
|
42 |
|
Vesting of early exercised options |
|
25,144 |
|
|
|
— |
|
|
|
31 |
|
|
|
— |
|
|
|
31 |
|
Issuance of common stock under ESPP |
|
41,146 |
|
|
|
— |
|
|
|
61 |
|
|
|
— |
|
|
|
61 |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
1,042 |
|
|
|
— |
|
|
|
1,042 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(12,486 |
) |
|
|
(12,486 |
) |
Balance At March 31, 2023 |
|
35,624,127 |
|
|
$ |
35 |
|
|
$ |
285,541 |
|
|
$ |
(150,600 |
) |
|
$ |
134,976 |
|
Exercise of common stock options |
|
351,879 |
|
|
|
— |
|
|
|
428 |
|
|
|
— |
|
|
|
428 |
|
Vesting of early exercised options |
|
16,517 |
|
|
|
— |
|
|
|
11 |
|
|
|
— |
|
|
|
11 |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
776 |
|
|
|
— |
|
|
|
776 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(8,404 |
) |
|
|
(8,404 |
) |
Balance At June 30, 2023 |
|
35,992,523 |
|
|
$ |
35 |
|
|
$ |
286,756 |
|
|
$ |
(159,004 |
) |
|
$ |
127,787 |
|
Exercise of common stock options |
|
64,112 |
|
|
|
— |
|
|
|
133 |
|
|
|
— |
|
|
|
133 |
|
Vesting of early exercised options |
|
5,501 |
|
|
|
— |
|
|
|
14 |
|
|
|
— |
|
|
|
14 |
|
Issuance of common stock under ESPP |
|
21,606 |
|
|
|
— |
|
|
|
30 |
|
|
|
— |
|
|
|
30 |
|
Stock-based compensation expense |
|
— |
|
|
|
— |
|
|
|
599 |
|
|
|
— |
|
|
|
599 |
|
Net loss |
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(3,532 |
) |
|
|
(3,532 |
) |
Balance At September 30, 2023 |
|
36,083,742 |
|
|
$ |
35 |
|
|
$ |
287,532 |
|
|
$ |
(162,536 |
) |
|
$ |
125,031 |
|
See accompanying notes to condensed consolidated financial statements.
4
CYTEIR THERAPEUTICS, INC.
Condensed consolidated statements of cash flows
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
(in thousands) (unaudited) |
|
2023 |
|
|
2022 |
|
Cash flows from operating activities: |
|
|
|
|
|
|
Net loss |
|
$ |
(24,422 |
) |
|
$ |
(37,268 |
) |
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
|
|
Depreciation and amortization expense |
|
|
368 |
|
|
|
498 |
|
Stock-based compensation |
|
|
2,417 |
|
|
|
3,813 |
|
Non-cash lease expense |
|
|
158 |
|
|
|
551 |
|
Loss on disposal of property and equipment |
|
|
925 |
|
|
|
— |
|
Gain on lease terminations and modification |
|
|
(318 |
) |
|
|
— |
|
Changes in operating assets and liabilities: |
|
|
|
|
|
|
Prepaid expenses and other current assets |
|
|
686 |
|
|
|
(179 |
) |
Accounts payable |
|
|
(620 |
) |
|
|
(119 |
) |
Accrued expenses and other current liabilities |
|
|
1,940 |
|
|
|
(2,912 |
) |
Other long term liabilities |
|
|
(6 |
) |
|
|
1 |
|
Net cash used in operating activities |
|
$ |
(18,872 |
) |
|
$ |
(35,615 |
) |
Cash flows from investing activities: |
|
|
|
|
|
|
Purchases of property and equipment |
|
|
— |
|
|
|
(312 |
) |
Proceeds from sales of property and equipment |
|
|
303 |
|
|
|
— |
|
Net cash provided by (used) in investing activities |
|
$ |
303 |
|
|
$ |
(312 |
) |
Cash flows from financing activities: |
|
|
|
|
|
|
Proceeds from issuance of common stock under ESPP |
|
|
92 |
|
|
|
64 |
|
Proceeds from exercise of stock options |
|
|
603 |
|
|
|
31 |
|
Net cash provided by financing activities |
|
$ |
695 |
|
|
$ |
95 |
|
Net decrease in cash, cash equivalents, and restricted cash |
|
|
(17,874 |
) |
|
|
(35,832 |
) |
Cash, cash equivalents and restricted cash at beginning of period |
|
|
147,377 |
|
|
|
189,979 |
|
Cash, cash equivalents and restricted cash at end of period |
|
$ |
129,503 |
|
|
$ |
154,147 |
|
Supplemental disclosure of cash flows |
|
|
|
|
|
|
Remeasurement of operating lease liabilities and right-of-use assets due to lease modification |
|
$ |
(1,908 |
) |
|
|
— |
|
Vesting of early exercised options |
|
$ |
56 |
|
|
$ |
101 |
|
The following table provides a reconciliation of the cash, cash equivalents, and restricted cash balances as of each of the dates shown below:
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
Cash and cash equivalents |
|
$ |
129,242 |
|
|
$ |
153,890 |
|
Restricted cash (included in other assets) |
|
|
261 |
|
|
|
257 |
|
Total cash, cash equivalents, and restricted cash |
|
$ |
129,503 |
|
|
$ |
154,147 |
|
See accompanying notes to condensed consolidated financial statements.
5
CYTEIR THERAPEUTICS, INC.
Notes to condensed consolidated financial statements – (unaudited)
1. Nature of the business
On June 30, 2023, Cyteir Therapeutics, Inc., (the “Company”) announced the discontinuation of development of CYT-0851, its investigational monocarboxylate transporter inhibitor, and that the Company would initiate a plan to liquidate its assets following an orderly wind down of the Company’s operations, and return remaining cash to shareholders. On September 7, 2023, the Board of Directors of the Company unanimously approved, subject to stockholder approval, the liquidation and dissolution of the Company pursuant to a plan of liquidation and dissolution (the “Plan of Dissolution”) that includes the distribution of remaining cash to stockholders following an orderly wind down of the Company’s operations, including the proceeds, if any, from the sale of its assets. Prior to winding down operations, the Company intends to complete regulatory and patient obligations from the ongoing clinical trial. The Company has engaged independent advisors, who are experienced in the dissolution and liquidation of companies, to assist in the Company’s dissolution and liquidation. The Company has called a special meeting of its stockholders on November 16, 2023 to seek approval of the Plan of Dissolution and filed definitive proxy materials relating to the special meeting with the Securities and Exchange Commission (the “SEC”) on October 12, 2023. If the Company’s stockholders approve the Plan of Dissolution and the likelihood is remote that the Company would return from liquidation, the Company would consider liquidation as imminent and implement liquidation basis of accounting.
CYT-0851 was being evaluated in a Phase 1 combination study with capecitabine or gemcitabine in advanced ovarian cancer and other solid tumors. The Company will continue to treat patients currently enrolled in the Company’s Phase 1/2 study of CYT-0851 as a monotherapy and in a combination study with capecitabine or gemcitabine until the conclusion of the study. Through 2022, the Company used its expertise in DNA damage response biology and a disciplined approach to select targets for other novel, differentiated programs with the aim of building a patient-centric portfolio of effective cancer therapies. In January 2023, the Company announced a strategic prioritization that included the discontinuation of these preclinical efforts.
The Company was formed as a Delaware corporation on June 4, 2012, pursuant to the General Corporation Law of the State of Delaware. The Company has a principal office in Lexington, Massachusetts.
Liquidity
The Company has incurred net operating losses since inception and has funded its operations primarily with proceeds from the sale of redeemable convertible preferred stock and the issuance of common stock in its initial public offering, or IPO. As of September 30, 2023, the Company had cash and cash equivalents of $129.2 million and an accumulated deficit of $162.5 million. The Company expects its operating losses and negative operating cash flows to continue into the foreseeable future.
The Company expects that its cash and cash equivalents as of September 30, 2023 will be sufficient to fund its operating expenses and capital expenditure requirements for at least twelve months from the date these condensed consolidated financial statements are available to be issued, or until the effectiveness of the Company’s dissolution.
6
2. Summary of significant accounting policies
The Company's significant accounting policies are disclosed in the audited consolidated financial statements for the years ended December 31, 2022 and 2021 ("audited financial statements"), which are included in the Company's Annual Report on Form 10-K that was filed with the SEC on March 23, 2023. Since the date of the financial statements, there have been no changes to the Company's significant accounting policies, except as noted below.
Interim Financial Information
The accompanying condensed consolidated balance sheet at September 30, 2023, and the condensed consolidated statements of operations, statements of changes in stockholders’ equity for the three and nine months ended September 30, 2023 and 2022 and condensed consolidated statements of cash flows for the nine months ended September 30, 2023 and 2022 are unaudited. The condensed consolidated interim financial statements have been prepared on the same basis as the audited annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments necessary for the fair presentation of the Company’s financial position at September 30, 2023 and the results of its operations for the three and nine months ended September 30, 2023 and 2022 and its cash flows for the nine months ended September 30, 2023 and 2022. The financial data and other information disclosed in these notes related to the three and nine months ended September 30, 2023 and 2022 are also unaudited. The results for the three and nine months ended September 30, 2023 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.
7
3. Fair value measurement
The following tables present information about the Company’s financial assets and liabilities measured at fair value on a recurring basis (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
Assets: |
|
Total |
|
|
Quoted prices in active markets for identical assets (level 1) |
|
|
Significant other observable inputs (level 2) |
|
|
Significant other observable inputs (level 3) |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
128,954 |
|
|
$ |
128,954 |
|
|
$ |
— |
|
|
$ |
— |
|
Total assets |
|
$ |
128,954 |
|
|
$ |
128,954 |
|
|
$ |
|
|
|
$ |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2022 |
|
Assets |
|
Total |
|
|
Quoted prices in active markets for identical assets (level 1) |
|
|
Significant other observable inputs (level 2) |
|
|
Significant other observable inputs (level 3) |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
146,870 |
|
|
$ |
146,870 |
|
|
$ |
— |
|
|
$ |
— |
|
Total assets |
|
$ |
146,870 |
|
|
$ |
146,870 |
|
|
$ |
— |
|
|
$ |
— |
|
During the nine months ended September 30, 2023 and the year ended December 31, 2022, there were no transfers between levels. The fair values of the Company’s cash equivalents, consisting of its standard checking accounts and money market funds, are based on quoted market prices in active markets without any valuation adjustment.
The Company uses the carrying amounts of its restricted cash, prepaid expenses and other current assets, accounts payable and accrued expenses and other current liabilities to approximate their fair value due to the short-term nature of these amounts.
4. Prepaid expenses and other current assets
Prepaid expenses and other current assets consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Prepaid research and development expenses |
|
$ |
37 |
|
|
$ |
786 |
|
Prepaid insurance |
|
|
1,023 |
|
|
|
982 |
|
Prepaid other |
|
|
324 |
|
|
|
304 |
|
Other receivables |
|
|
17 |
|
|
|
17 |
|
Total |
|
$ |
1,401 |
|
|
$ |
2,089 |
|
5. Property and equipment, net
On January 19, 2023, the Company announced a strategic prioritization of clinical development of CYT-0851, which included the discontinuation of preclinical efforts and a workforce reduction by approximately 70% of the Company's
8
workforce. For the nine months ended September 30, 2023, the Company recognized a loss on disposal of property and equipment totaling $0.9 million on the Company's condensed consolidated statement of operations.
Property and equipment, net consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
Acquisition cost |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
1,846 |
|
|
$ |
1,675 |
|
|
$ |
3,521 |
|
Disposals |
|
|
(1,752 |
) |
|
|
(1,266 |
) |
|
|
(3,018 |
) |
As of September 30, 2023 |
|
$ |
94 |
|
|
$ |
409 |
|
|
$ |
503 |
|
|
|
|
|
|
|
|
|
|
|
Accumulated depreciation and amortization |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
(827 |
) |
|
$ |
(995 |
) |
|
$ |
(1,822 |
) |
Depreciation expense |
|
|
(63 |
) |
|
|
(305 |
) |
|
|
(368 |
) |
Disposals |
|
|
866 |
|
|
|
926 |
|
|
|
1,792 |
|
As of September 30, 2023 |
|
$ |
(24 |
) |
|
$ |
(374 |
) |
|
$ |
(398 |
) |
|
|
|
|
|
|
|
|
|
|
Carrying amount |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
1,019 |
|
|
$ |
680 |
|
|
$ |
1,699 |
|
As of September 30, 2023 |
|
$ |
70 |
|
|
$ |
35 |
|
|
$ |
105 |
|
For the three months ended September 30, 2023 and 2022, depreciation and amortization expense related to property and equipment was $0.1 million and $0.2 million, respectively. For the nine months ended September 30, 2023 and 2022, depreciation and amortization expense related to property and equipment was $0.4 million and $0.5 million, respectively.
6. Accrued expenses and other current liabilities
Accrued expenses and other current liabilities consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Accrued research and development expenses |
|
$ |
1,646 |
|
|
$ |
1,356 |
|
Accrued compensation |
|
|
3,449 |
|
|
|
1,510 |
|
Accrued other |
|
|
350 |
|
|
|
432 |
|
Operating lease liabilities |
|
|
16 |
|
|
|
889 |
|
Total accrued expenses and other current liabilities |
|
$ |
5,461 |
|
|
$ |
4,187 |
|
7. Common stock
The voting, dividend and liquidation rights of the holders of the Company’s common stock are subject to and qualified by the rights, powers and preferences of the holders of the preferred stock as set forth in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2022.
The holders of the common stock are entitled to one vote for each share of common stock held submitted to a vote of stockholders, and there are not any cumulative voting rights. Holders of common stock are entitled to receive proportionately any dividends as may be declared by the Company's board of directors subject to any preferential dividend rights of any series of preferred stock that the Company may designate and issue in the future.
As of September 30, 2023 and December 31, 2022, the Company has reserved the following shares of common stock for the potential exercise of stock options:
9
|
|
|
|
|
|
|
|
|
|
|
September 30, |
|
|
December 31, |
|
|
|
2023 |
|
|
2022 |
|
Options to purchase common stock |
|
|
2,672,831 |
|
|
|
3,460,897 |
|
Remaining shares reserved for future issuance |
|
|
7,820,567 |
|
|
|
5,706,345 |
|
Total |
|
|
10,493,398 |
|
|
|
9,167,242 |
|
8. Stock-based compensation
2012 Stock Incentive Plan
The Company adopted the 2012 Stock Incentive Plan (the “2012 Plan”) in November 2012 pursuant to which the Company can issue incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock awards, restricted stock unit awards and other stock awards. Recipients of stock options or stock appreciate rights shall be eligible to purchase shares of the Company’s common stock at an exercise price equal to the estimated fair market value of such stock on the date of grant. The exercise price may be less than fair market value if the stock award is granted pursuant to an assumption or substitution for another stock award in the event of a merger or sale of the Company. The maximum term of options granted under the 2012 Plan is ten years, and stock options typically vest over a four-year period. The Board may assign vesting terms to the stock option grants as deemed appropriate. The Company also has the right of refusal to purchase any proposed disposition of shares issued under the 2012 Plan. The 2012 Plan allows for early exercise of all stock option grants if authorized by the Board at the time of grant. The shares of common stock issued from the early exercise of stock options are restricted and vest over time. The Company has the option to repurchase any unvested shares at the original purchase price upon any voluntary or involuntary termination. At the discretion of the Board, unvested shares held by employees may accelerate vesting in the event of a change of control of the Company unless assumed or substituted by the acquirer or surviving entity. The 2012 Plan has been subsequently amended and provides for the issuance of up to 6,941,421 shares of common stock as of September 30, 2023, of which 2,732,632 shares of common stock remained available for future grant under the 2012 Plan upon the effectiveness of the 2021 Equity Incentive Plan (the “2021 Plan”) and were made available for future issuance under the 2021 Plan.
2021 Equity Incentive Plan
In June 2021, the Company’s board of directors adopted and the Company’s stockholders approved the 2021 Plan, which became effective immediately prior to the effectiveness of the registration statement for the IPO. The 2021 Plan provides for the grant of incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock awards, restricted stock units and other stock-based awards. Upon effectiveness of the 2021 Plan, the number of shares of common stock reserved for issuance under the 2021 Plan was 5,932,632, which represents 3,200,000 shares along with 2,732,632 shares of common stock reserved for issuance under the 2012 Plan that remained available for grant under the 2012 Plan immediately prior to the effectiveness of the 2021 Plan. Shares of the Company's common stock subject to outstanding awards granted under the 2012 Plan that expire unexercised or are terminated, surrendered, cancelled, forfeited or repurchased by the Company at their original issuance price pursuant to a contractual repurchase right will become available for issuance under the 2021 Plan. Upon adoption of the 2021 Plan, the Company ceased the grant of additional awards under the 2012 Plan. The 2021 Plan includes an "evergreen" provision, which provides for an annual increase to be added on January 1st of each year beginning in 2022 and continuing through and including 2031 by the lesser of (i) 5% of the number of shares of Stock outstanding as of such date and (ii) an amount determined by the board of directors. On January 1, 2023, the number of shares of Common Stock reserved and available for issuance under the 2021 Plan increased by 1,778,784 shares.
At September 30, 2023, 7,820,567 shares of common stock remained available for future grant under the 2021 Plan.
2021 Employee Stock Purchase Plan
In June 2021, the Company’s board of directors adopted, and the Company’s stockholders approved, the 2021 Employee Stock Purchase Plan (the “ESPP”), which became effective immediately prior to the effectiveness of the registration statement for the IPO. The ESPP is administered by the compensation committee of the Company’s board of directors, except that the Company’s board of directors may at any time act as the administrator of the ESPP. On July 13, 2023, the Compensation Committee suspended all future purchases under the ESPP, effective as of July 14, 2023, such that no new ESPP option periods will commence after July 14, 2023.
The ESPP provides participating employees with the opportunity to purchase shares of common stock, with an initial aggregate share pool of 300,000 shares of common stock. The number of shares of common stock reserved for issuance under the ESPP will automatically increase on January 1st of each year beginning in 2022 and continuing through and including 2031 by the least of (i) 1% of the number of shares of Stock outstanding as of such date, (ii) 600,000 shares of
10
Stock and (iii) the number of shares of Stock determined by the Company’s board of directors on or prior to such date for such year, up to a maximum of 6,300,000 shares in the aggregate. On January 1, 2023, the number of shares of Common Stock reserved and available for issuance under the ESPP increased by 355,756 shares.
The ESPP allows eligible employees to authorize payroll deductions of between 1% and 15% of their regular base salary or wages to be applied toward the purchase of shares of the Company's common stock on the last trading day of the offering period, subject to certain limitations contained in the ESPP. Participating employees will purchase shares of the Company's common stock at a discount of 15% on the lesser of the closing price of the Company's common stock on the Nasdaq Global Select Market (i) on the first trading day of the offering period or (ii) the last trading day of the offering period. The Company utilizes the Black Scholes option pricing model to compute the fair market value of the shares subject to outstanding options under the ESPP and compensation expense is recognized over the offering period.
Participation in the ESPP is voluntary. Eligible employees become participants in the ESPP by enrolling in the plan and authorizing payroll deductions in accordance with the terms of the ESPP. At the end of each offering period, accumulated payroll deductions are used to purchase the Company’s shares at the discounted price. The Company makes no contributions to the ESPP. A participant may withdraw from the ESPP or reduce contributions to the ESPP during an offering period. If the participant elects to withdraw during an offering period, all contributions are refunded as soon as administratively practicable. If a participant elects to withdraw during an offering period, the participant may not re-enroll in the current offering but may elect to participate in future offerings, subject to the terms of the ESPP. Only whole shares of the Company may be purchased under the ESPP.
The Company issued 62,754 common shares under the ESPP during the nine months ended September 30, 2023 at an average price per share of $1.45. Cash received from purchases under the ESPP for the nine months ended September 30, 2023 was $0.1 million. The Company recognized an immaterial amount of compensation expense for the ESPP during the nine months ended September 30, 2023.
Early exercise of unvested stock options
Shares purchased by employees pursuant to the early exercise of stock options are not deemed, for accounting purposes, to be outstanding shares until those shares vest according to their respective vesting schedules. Cash received from employee exercises of unvested options is included in long-term liabilities on the condensed consolidated balance sheets. Amounts recorded are reclassified to common stock and additional paid-in capital as the shares vest. As of September 30, 2023 and December 31, 2022, there were 7,333 and 59,445 unvested shares related to early exercises of stock options, respectively.
Stock option valuation
The assumptions that the Company used in the Black Scholes option-pricing model to determine the grant date fair value of stock options granted were as follows:
|
|
|
|
|
|
September 30, 2023 |
December 31, 2022 |
Risk-free interest rate range |
|
3.64-3.65% |
1.89%-4.23% |
Dividend yield |
|
0.0% |
0.0% |
Expected life of options (years) |
|
6.0 |
6.0 |
Volatility rate range |
|
93.0-93.3% |
92.4%-93.3% |
The following table summarizes the Company’s stock option activity during the nine months ended September 30, 2023:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average exercise price |
|
|
Weighted average remaining contractual term (in years) |
|
|
Aggregate intrinsic value (in thousands) |
|
Outstanding as of December 31, 2022 |
|
|
3,460,897 |
|
|
$ |
5.60 |
|
|
|
8.23 |
|
|
$ |
375 |
|
Granted |
|
|
1,054,357 |
|
|
$ |
1.69 |
|
|
|
— |
|
|
|
— |
|
Exercised |
|
|
(457,579 |
) |
|
$ |
1.32 |
|
|
|
— |
|
|
|
— |
|
Forfeited or cancelled |
|
|
(1,384,844 |
) |
|
$ |
5.55 |
|
|
|
— |
|
|
|
— |
|
Outstanding as of September 30, 2023 |
|
|
2,672,831 |
|
|
$ |
4.82 |
|
|
|
8.02 |
|
|
$ |
1,530 |
|
Options vested and exercisable as of September 30, 2023 |
|
|
1,439,617 |
|
|
$ |
6.04 |
|
|
|
7.37 |
|
|
$ |
575 |
|
11
As of September 30, 2023, there was $2.9 million of unrecognized stock-based compensation expense related to the share-based compensation arrangements under the 2012 Plan. The Company expects to recognize this amount over a weighted-average period of 2.3 years.
The aggregate intrinsic value of options is calculated as the difference between the exercise price of the stock options and the fair value of the Company’s common stock for those stock options that had exercise prices lower than the fair value of the common stock as of the end of the reporting period. There were no stock options granted during the three months ended September 30, 2023. The weighted-average grant date fair value of the Company’s stock options granted during the three months ended September 30, 2022 was $1.78.
The total fair value of options vested during the three months ended September 30, 2023 and 2022 was $2.0 million and $1.8 million, respectively.
Stock-based compensation expense
Stock-based compensation expense included in the Company’s condensed consolidated statements of operations is as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Research and development |
$ |
183 |
|
|
$ |
505 |
|
|
$ |
820 |
|
|
$ |
1,393 |
|
General and administrative |
|
416 |
|
|
|
688 |
|
|
|
1,597 |
|
|
|
2,420 |
|
Total stock-based compensation expense |
$ |
599 |
|
|
$ |
1,193 |
|
|
$ |
2,417 |
|
|
$ |
3,813 |
|
9. Net loss per share
The Company’s potentially dilutive securities have been excluded from the computation of diluted net loss per share as the effect would be to reduce the net loss per share. Therefore, the weighted-average number of common shares outstanding used to calculate both basic and diluted net loss per share attributable to common stockholders is the same. The Company excluded the following shares from the computation of diluted net loss per share attributable to common stockholders as of September 30, 2023 and 2022 because including them would have had an anti-dilutive effect:
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
Options to purchase common stock |
|
|
2,672,831 |
|
|
|
3,659,788 |
|
Unvested shares from early exercises |
|
|
7,333 |
|
|
|
84,771 |
|
10. Commitments and Contingencies
Legal proceedings
From time to time, in the ordinary course of business, the Company is subject to litigation and regulatory examinations as well as information gathering requests, inquiries and investigations. As of September 30, 2023, there were no matters which would have a material impact on the Company’s financial results.
11. Leases
Operating Lease
In August 2018, the Company entered into an operating lease agreement (the "Lease") for office and laboratory space within the building complex located at 128 Spring Street in Lexington, Massachusetts. The Lease commenced in November 2018, and as subsequently amended, is approximately 14,636 rentable square feet (“Original Premises”) and had a maturity date of October 31, 2023. In July 2021, the Company entered into the second amendment of the Lease and expanded the office space by approximately 5,531 square feet (the “Expansion Premises”), and extended the maturity date to December 31, 2025 for both the Original Premises and Expansion Premises. Lease payments are made monthly, subject to a 3% annual rent increase, and the Company pays for its proportionate share of building operating costs such as maintenance, utilities, and insurance that are treated as variable costs and excluded from the measurement of the Lease.
12
On March 29, 2023, the Company entered into a Lease Amendment and Termination Agreement (the “Amendment”) with respect to the operating lease with 99 Hayden LLC, which covers certain laboratory and office space at Ledgemont Technology Center at 99 Hayden Avenue, Lexington, Massachusetts (the “Premises”). The Amendment amends the terms of the Lease to terminate the Lease as of March 31, 2023, subject to completion of the requisite surrender requirements, with respect to approximately 14,636 rentable square feet consisting of office and lab space located on two floors of the Premises, and 140 rentable square feet of storage space located on the Premises. Under the terms of the Amendment, the Company retained and consolidated into the remaining 5,531 rentable square feet of office space under the Lease at the Premises, which were to serve as the Company's principal executive office, until October 31, 2023, at which time the Lease would have terminated in its entirety. The Company recognized a gain on lease terminations and modification of $0.3 million for the nine months ended September 30, 2023 on the condensed consolidated statement of operations and derecognized $2.2 million in lease liabilities and $1.9 million in right of use assets on the condensed consolidated balance sheets.
The following table summarizes the presentation of the Company's operating leases on its consolidated balance sheet:
|
|
|
|
|
|
|
|
|
Leases |
Balance sheet classification |
|
September 30, 2023 |
|
December 31, 2022 |
|
Assets |
|
|
|
|
|
|
Operating lease assets |
Other assets |
|
$ |
— |
|
$ |
2,066 |
|
Liabilities |
|
|
|
|
|
|
Current |
|
|
|
|
|
|
Operating lease liabilities |
Accrued expenses and other current liabilities |
|
$ |
16 |
|
$ |
889 |
|
Noncurrent |
|
|
|
|
|
|
Operating lease liabilities |
Other long term liabilities |
|
|
— |
|
|
1,560 |
|
Total lease liabilities |
|
|
$ |
16 |
|
$ |
2,449 |
|
The components of lease cost under ASC 842 included in the Company’s condensed consolidated statement of operations for the nine months ended September 30, 2023 and 2022 were as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
Lease Cost |
Statement of operations classification |
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Operating lease cost |
Research and development |
|
$ |
11 |
|
|
$ |
143 |
|
|
$ |
141 |
|
|
$ |
447 |
|
Operating lease cost |
General and administrative |
|
|
7 |
|
|
|
44 |
|
|
|
88 |
|
|
|
124 |
|
Variable lease cost |
Research and development |
|
|
— |
|
|
|
100 |
|
|
|
101 |
|
|
|
344 |
|
Variable lease cost |
General and administrative |
|
|
— |
|
|
|
31 |
|
|
|
63 |
|
|
|
96 |
|
Total lease cost |
|
|
$ |
18 |
|
|
$ |
318 |
|
|
$ |
393 |
|
|
$ |
1,011 |
|
The weighted average remaining lease term and weighted average discount rate of the operating leases was 0.1 years and 5.0%, respectively, at September 30, 2023. The Company made cash payments for amounts included in the measurement of operating liabilities of $0.3 million for the nine months ended September 30, 2023.
Future minimum lease payments under non-cancellable operating leases as of September 30, 2023 were as follows (in thousands):
|
|
|
|
|
Maturity of lease liabilities |
|
Amount |
|
2023 (excluding the nine months ended September 30, 2023) |
|
$ |
16 |
|
Less: interest |
|
|
— |
|
Present value of operating lease liabilities |
|
$ |
16 |
|
12. Employee benefit plans
The Company has a 401(k) retirement plan for its employees, which is designed to be qualified under Section 401(k) of the Internal Revenue Code. Eligible employees are permitted to contribute to the 401(k) plan within statutory and 401(k) plan limits. The Company implemented a matching contribution in 2022 and has made $0.1 million matching contributions for the nine months ended September 30, 2023.
13
13. Restructuring
On January 19, 2023, the Company announced a strategic prioritization of clinical development of CYT-0851, which included the discontinuation of preclinical efforts and a workforce reduction by approximately 70% of the Company's workforce. For the nine months ended September 30, 2023, the Company incurred $4.4 million of restructuring charges related to termination benefits and other related charges of which $2.5 million and $1.8 million, respectively, were recorded in research and development expenses and general and administrative expenses in the Company's condensed consolidated statements of operations. Non-cash expenses related to the strategic prioritization, consisting of an estimated $0.9 million loss on disposal of property and equipment and a gain of $0.3 million on lease terminations and modification and were recorded in other income (expense) in the Company's condensed consolidated statements of operations.
On June 30, 2023, the Company's Board of Directors announced its discontinuation of all development of CYT-0851 and intention to dissolve the Company. On September 7, 2023, our Board of Directors unanimously approved, subject to stockholder approval, the liquidation and dissolution of the Company pursuant to a plan of liquidation and dissolution. For the three months ended September 30, 2023, the Company reduced restructuring charges by $0.3 million related to termination benefits which was recorded in research and development expenses in the Company's condensed consolidated statements of operations. For the nine months ended September 30, 2023, the Company made $2.3 million of cash payments related to the restructuring. As of September 30, 2023, the restructuring accrual was approximately $2.1 million and was recorded in accrued expenses and other current liabilities in the Company's condensed consolidated balance sheet.
The following table outlines the Company's restructuring activities for the nine months ended September 30, 2023 (in thousands):
|
|
|
|
|
Opening Balance - December 31, 2022 |
|
$ |
- |
|
Employee termination-related charges |
|
|
4,370 |
|
Payments |
|
|
(2,318 |
) |
Balance - September 30, 2023 |
|
$ |
2,052 |
|
14. Subsequent events
On October 3, 2023, the Company entered into the fourth amendment of the Lease and extended the term of the Lease for an additional one-month term, commencing on November 1, 2023 and expiring on November 30, 2023. Under the terms of the fourth amendment, the Company will continue to lease 5,531 square feet of office space pursuant to the Lease, which will continue to serve as the Company's principal executive office during the extended term.
14
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.
The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our consolidated financial statements and the related notes to those statements included elsewhere in this Quarterly Report on Form 10-Q and our audited financial statements and notes thereto for the year ended December 31, 2022, included in our Annual Report on Form 10-K that was filed on March 23, 2023 with the U.S. Securities and Exchange Commission, or SEC.
In addition to historical financial information, the following discussion and analysis contains forward-looking statements that involve risks, uncertainties and assumptions. Some of the numbers included herein have been rounded for the convenience of presentation. Our actual results may differ materially from those anticipated in these forward-looking statements as a result of many factors, including those discussed under “Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022.
Overview
On June 30, 2023, we announced the discontinuation of development of CYT-0851, our investigational monocarboxylate transporter inhibitor, and that we would initiate a plan to liquidate our assets following an orderly wind down of our operations, dissolve the Company and return remaining cash to stockholders, or the Dissolution. On September 7, 2023, our Board of Directors unanimously approved, subject to stockholder approval, the liquidation and dissolution of the Company pursuant to a plan of liquidation and dissolution, or the Plan of Dissolution, that includes the distribution of remaining cash to stockholders following an orderly wind down of our operations, including the proceeds, if any, from the sale of its assets. Prior to winding down operations, we intend to complete regulatory and patient obligations from the ongoing clinical trial. We have engaged independent advisors, who are experienced in the dissolution and liquidation of companies, to assist in our dissolution and liquidation. We have called a special meeting of our stockholders on November 16, 2023 to seek approval of the Plan of Dissolution and filed definitive proxy materials relating to the special meeting with the Securities and Exchange Commission, or the SEC, on October 12, 2023.
The Dissolution contemplates an orderly wind down of our business and operations in accordance with the provisions of Delaware General Corporation Law, or the DGCL. If our stockholders approve the Dissolution, we intend to (i) file a Certificate of Dissolution with the Delaware Secretary of State, (ii) cease all of our business activities except those relating to winding up and liquidating our business and affairs, including, but not limited to, prosecuting and defending suits by or against us, if any, and ultimately closing our Phase 1/2 clinical trial of CYT-0851, (iii) collect, sell, exchange or otherwise dispose of our remaining non-cash property and assets, (iv) pay or make a reasonable provision to pay all claims and obligations, including all contingent, conditional or un-matured contractual claims known to us, (v) make such provision as will be reasonably likely to be sufficient to provide compensation for any claim against us which is the subject of a pending action, suit or proceeding to which we are a party, (vi) make such provision as will be reasonably likely to be sufficient to provide compensation for claims that have not been made known to us or that have not arisen but that, based on facts known to us, are likely to arise or become known to us within ten years after the date of dissolution, (vii) set aside a contingency reserve consisting of cash and/or property to satisfy such claims and contingent obligations of the Company, (viii) make a distribution of remaining cash to our stockholders of record as of the date we file our Certificate of Dissolution with the Delaware Secretary of State, and (ix) take any and all other actions permitted or required by the DGCL and any other applicable laws and regulations.
Pursuant to the DGCL, our corporate existence will continue for a period of at least three years following the date on which we file our Certificate of Dissolution with the Delaware Secretary of State, for the purpose of prosecuting and defending suits, winding up the Company and making distributions to stockholders, but not for the purpose of continuing to engage in any business for which the Company was organized.
If stockholders do not approve the plan of liquidation and dissolution, then we will not distribute cash to stockholders and we will continue our corporate existence and the Board of Directors will continue to explore strategic alternatives.
CYT-0851 was being evaluated in a Phase 1/2 study as a monotherapy treatment and in combination with capecitabine or gemcitabine in advanced ovarian cancer and other solid tumors. We will continue to treat patients currently enrolled in this study until the conclusion of the study.
CYT-0851 is an investigational monocarboxylate transporter inhibitor, or MCT inhibitor, initially evaluated in a Phase 1/2 study to treat patients with hematologic malignancies and solid tumors as a monotherapy and in combination with standard of care therapies. Inhibiting MCT function in glycolytic cancer cells leads to an accumulation of intracellular lactate that impairs glycolysis and inhibits tumor cell growth, making MCTs an attractive target for cancer therapy.
In January 2023, we reported preliminary clinical activity in a small number of patients observed in the Phase 1 dose-escalation cohort with CYT-0851 in combination with capecitabine in advanced ovarian cancer. In this combination
15
dose-escalation cohort, we enrolled a total of thirteen patients at dose levels of 100 mg to 400 mg of CYT-0851, which included five patients with advanced ovarian cancer. Based on the results of this study, we determined that 400 mg of CYT-0851 was the recommended Phase 2 dose in combination with capecitabine, and we expanded enrollment in the CYT-0851 and capecitabine combination cohort to enroll additional patients with advanced ovarian cancer. We discontinued enrollment in this study in connection with the announcement of the discontinuation of development of CYT-0851 in June 2023.
In January 2023, we announced the suspension of enrollment in the CYT-0851 Phase 2 monotherapy cohort due to insufficient activity observed with CYT-0851 alone. In addition to prioritizing CYT-0851 development as a potential combination therapy to treat advanced ovarian cancer at that time, we deferred all other research and development activities and reduced our headcount to 15 employees.
Since our inception in 2012, we have focused primarily on organizing and staffing our company, business planning, raising capital, establishing our intellectual property portfolio and performing research and development of novel therapeutics. We do not have any drug candidates approved for sale and have not generated any revenue from product sales. Since our inception, we have funded our operations primarily with proceeds from the sale of securities, including an aggregate of approximately $141.0 million of gross proceeds from the sale of redeemable convertible preferred stock and approximately $149.1 million of gross proceeds from the sale of common stock in our IPO, as of September 30, 2023.
We have incurred significant operating losses since inception, including net losses of $24.4 million and $37.3 million for the nine months ended September 30, 2023 and 2022, respectively. As of September 30, 2023 and December 31, 2022 we had an accumulated deficit of $162.5 million and $138.1 million, respectively. These losses have resulted primarily from costs incurred in connection with research and development activities and general and administrative costs associated with our operations. We expect to continue to generate operating losses and negative operating cash flows for the foreseeable future as we:
•continue to treat patients currently enrolled in our Phase 1/2 clinical study as a monotherapy and in combination with capecitabine or gemcitabine;
•execute the plan of liquidation and dissolution of the Company;
•obtain, maintain, protect and enforce our intellectual property portfolio; and
•experience delays or encounter issues with any of the above.
As of September 30, 2023, we had cash and cash equivalents of $129.2 million. We believe that our existing cash and cash equivalents as of September 30, 2023 will enable us to fund our operating expenses and capital expenditure requirements for at least twelve months from the date our condensed consolidated financial statements for the period ended September 30, 2023 are available to be issued, or until the effectiveness of our dissolution. We have based this estimate on assumptions that may prove to be wrong, and we could exhaust our available capital resources sooner than we expect. See “—Liquidity and Capital Resources.”
Components of results of operations
Revenue
To date, we have not generated any revenue from product sales.
Operating expenses
Research and development expenses
Research and development expenses consist primarily of costs incurred in connection with the preclinical and clinical development and manufacture of our drug candidates, and include:
•personnel-related expenses, including salaries, bonuses, benefits, stock-based compensation and other related costs for individuals involved in research and development activities;
•external research and development expenses incurred under agreements with CROs as well as investigative sites and consultants that conduct our clinical trials and other scientific development services;
•costs incurred under agreements with CMOs for developing and manufacturing material for our preclinical studies and clinical trials;
•costs of outside consultants, including their fees, stock-based compensation and related travel expenses;
16
•costs related to compliance with regulatory requirements;
•costs of laboratory supplies and acquiring, developing and manufacturing study materials; and
•facilities and other allocated expenses, which include direct and allocated expenses for rent, insurance and other operating costs.
Costs for external development activities are recognized based on an evaluation of the progress to completion of specific tasks using information provided to us by our vendors and our clinical investigative sites. Payments for these activities are based on the terms of the individual agreements, which may differ from the pattern of costs incurred, and are reflected in our consolidated financial statements as prepaid or accrued research and development expenses. Nonrefundable advance payments for goods or services to be received in the future for use in research and development activities are recorded as prepaid expenses and expensed as the related goods are delivered or the services are performed.
A significant portion of our research and development costs have been external costs, which we tracked on a program-by-program basis after a clinical drug candidate was identified. Our internal research and development costs were primarily personnel-related costs, internal lab costs and other indirect costs. The majority of our external research and development expenses to date have been incurred in connection with CYT-0851.
We do not allocate employee costs, costs associated with our discovery efforts, and facilities, including depreciation or other indirect costs, to specific programs because these costs are deployed across multiple programs and, as such, are not separately classified. We use internal resources and third-party consultants primarily to conduct our research and discovery activities as well as for managing our process development, manufacturing and clinical development activities.
We cannot reasonably estimate or know the nature, timing and estimated costs of the efforts that will be necessary to complete the liquidation and dissolution of the Company. Our level of costs may be highly variable on a quarterly basis.
General and administrative expenses
General and administrative expenses consist primarily of salaries and other related costs, including stock-based compensation, for personnel in our executive, finance, corporate and business development and administrative functions. General and administrative expenses also include professional fees for legal, patent, accounting, auditing, tax and consulting services, and facility-related expenses, which include direct depreciation costs and allocated expenses for rent and maintenance of facilities and other operating costs.
We expect to continue to incur general and administrative expenses in connection with our planned liquidation and dissolution of the Company.
Other income (expense)
Other income (expense) primarily consists of interest income earned on cash equivalents that generate interest on a monthly basis.
Results of operations
Comparison of the three months ended September 30, 2023 and 2022
The following table summarizes our results of operations:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
|
|
(in thousands) |
|
2023 |
|
|
2022 |
|
|
Change |
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
Research and development |
|
$ |
2,676 |
|
|
$ |
8,272 |
|
|
$ |
(5,596 |
) |
General and administrative |
|
|
2,495 |
|
|
|
3,487 |
|
|
|
(992 |
) |
Total operating expenses |
|
|
5,171 |
|
|
|
11,759 |
|
|
|
(6,588 |
) |
Loss from operations |
|
|
(5,171 |
) |
|
|
(11,759 |
) |
|
|
6,588 |
|
Other income(expense): |
|
|
|
|
|
|
|
|
|
Interest income |
|
|
1,639 |
|
|
|
714 |
|
|
|
925 |
|
Total other income(expense) |
|
|
1,639 |
|
|
|
714 |
|
|
|
925 |
|
Net loss |
|
$ |
(3,532 |
) |
|
$ |
(11,045 |
) |
|
$ |
7,513 |
|
17
Research and development expenses
The following table summarizes our research and development costs for each of the periods presented:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
|
|
(in thousands) |
|
2023 |
|
|
2022 |
|
|
Change |
|
Direct research and development expenses by program: |
|
|
|
|
|
|
|
|
|
MCT inhibitor programs |
|
$ |
1,611 |
|
|
$ |
3,122 |
|
|
$ |
(1,511 |
) |
Unallocated research and development expenses: |
|
|
|
|
|
|
|
|
|
Personnel expenses (including stock-based compensation) |
|
|
910 |
|
|
|
3,207 |
|
|
|
(2,297 |
) |
Other expenses |
|
|
155 |
|
|
|
1,943 |
|
|
|
(1,788 |
) |
Total research and development expenses |
|
$ |
2,676 |
|
|
$ |
8,272 |
|
|
$ |
(5,596 |
) |
Research and development expenses for the three months ended September 30, 2023 were $2.7 million, which decreased by $5.6 million from $8.3 million for the three months ended September 30, 2022. The decrease in research and development expenses was primarily attributable to the following:
•a $1.5 million decrease in costs related to our MCT inhibitor programs driven by decreased costs in external research activities and costs related to our ongoing clinical trial;
•a $2.3 million decrease in personnel-related costs, including stock-based compensation expense, primarily due to decreased headcount associated with our strategic prioritization and restructuring; and
•a $1.8 million decrease in other research and development operational expenses, including facilities and lab-related costs as well as costs related to our discovery efforts.
General and administrative expenses
General and administrative expenses for the three months ended September 30, 2023 were $2.5 million, which decreased by $1.0 million from $3.5 million for the three months ended September 30, 2022. The decrease in general and administrative expenses was primarily attributable the following:
•a $0.7 million decrease in personnel-related costs, including stock-based compensation expense, primarily due to decreased headcount associated with our strategic prioritization and restructuring; and
•a $0.3 million decrease in other general and administrative expenses, primarily driven by insurance, IT and facilities related costs.
Total other income (expense)
Total other income (expense) for three months ended September 30, 2023 was $1.6 million, which increased by $0.9 million from $0.7 million for the three months ended September 30, 2022. The increase in other income (expense) was attributable to the increase in interest income due to higher interest rates on our cash equivalents, which are primarily invested in money market funds.
18
Comparison of the nine months ended September 30, 2023 and 2022
The following table summarizes our results of operations:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
|
(in thousands) |
|
2023 |
|
|
2022 |
|
|
Change |
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
Research and development |
|
$ |
17,391 |
|
|
$ |
27,154 |
|
|
$ |
(9,763 |
) |
General and administrative |
|
|
10,809 |
|
|
|
10,963 |
|
|
|
(154 |
) |
Total operating expenses |
|
|
28,200 |
|
|
|
38,117 |
|
|
|
(9,917 |
) |
Loss from operations |
|
|
(28,200 |
) |
|
|
(38,117 |
) |
|
|
9,917 |
|
Other income(expense): |
|
|
|
|
|
|
|
|
|
Interest income |
|
|
4,385 |
|
|
|
849 |
|
|
|
3,536 |
|
Loss on disposal of property and equipment |
|
|
(925 |
) |
|
|
— |
|
|
|
(925 |
) |
Gain on lease terminations and modification |
|
|
318 |
|
|
|
— |
|
|
|
318 |
|
Total other income(expense) |
|
|
3,778 |
|
|
|
849 |
|
|
|
2,929 |
|
Net loss |
|
$ |
(24,422 |
) |
|
$ |
(37,268 |
) |
|
$ |
12,846 |
|
The following table summarizes our research and development costs for each of the periods presented:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
|
(in thousands) |
|
2023 |
|
|
2022 |
|
|
Change |
|
Direct research and development expenses by program: |
|
|
|
|
|
|
|
|
|
MCT inhibitor programs |
|
$ |
8,036 |
|
|
$ |
12,699 |
|
|
$ |
(4,663 |
) |
Unallocated research and development expenses: |
|
|
|
|
|
|
|
|
|
Personnel expenses (including stock-based compensation) |
|
|
7,624 |
|
|
|
9,311 |
|
|
|
(1,687 |
) |
Other expenses |
|
|
1,731 |
|
|
|
5,144 |
|
|
|
(3,413 |
) |
Total research and development expenses |
|
$ |
17,391 |
|
|
$ |
27,154 |
|
|
$ |
(9,763 |
) |
Research and development expenses for the nine months ended September 30, 2023 were $17.4 million, which decreased by $9.8 million from $27.2 million for the nine months ended September 30, 2022. The decrease in research and development expenses was primarily attributable to the following:
•a $4.7 million decrease in costs related to our MCT inhibitor programs driven by decreased costs in external research activities and costs related to our ongoing clinical trial;
•a $1.7 million decrease in personnel-related costs, including stock-based compensation expense, primarily due to decreased headcount associated with our strategic prioritization and restructuring; and
•a $3.4 million decrease in other research and development operational expenses, including facilities and lab-related costs as well as costs related to our discovery efforts.
General and administrative expenses
General and administrative expenses for the nine months ended September 30, 2023 were $10.8 million, which decreased by $0.2 million from $11.0 million for the nine months ended September 30, 2022. The decrease in general and administrative expenses was primarily attributable to the following:
•a $0.6 million decrease in other general and administrative expenses, primarily driven by decreased insurance costs; offset by
•a $0.4 million increase in personnel costs, including stock-based compensation expense, primarily due to severance-related costs associated with our strategic prioritization and restructuring.
19
Total other income (expense)
Total other income (expense) for the nine months ended September 30, 2023 was $3.8 million, which increased by $3.0 million from $0.8 million for the nine months ended September 30, 2022. The increase in other income (expense) was attributable to the following:
•a $3.6 million increase in interest income due to higher interest rates on our cash equivalents, which are primarily invested in money market funds;
•a $0.3 million increase due to gain on lease terminations and modification; offset by
•a $0.9 million decrease due to loss on disposal of property and equipment.
Liquidity and capital resources
Sources of liquidity
Since our inception, we have not recognized any product revenue and have incurred operating losses and negative cash flows from our operations. We have not commercialized any product and we do not expect to generate revenue from sales of any products prior to our dissolution.
We have funded our operations primarily with proceeds from the sale of redeemable convertible preferred stock and the sale of our common stock in our IPO. From inception through September 30, 2023, we have raised an aggregate of approximately $141.0 million from the sale of redeemable convertible preferred stock and $136.1 million in net proceeds from the sale of our common stock with the completion of the IPO.
Funding requirements
As of September 30, 2023, our cash and cash equivalents on hand were $129.2 million. We believe that our existing cash and cash equivalents as of September 30, 2023 will be sufficient to fund our operating expenses and capital expenditure requirements for at least twelve months from the date the condensed consolidated financial statements for the period ended September 30, 2023 are available to be issued, or until the effectiveness of the Company’s dissolution. We have based this estimate on assumptions that may prove to be wrong, and we could expend our capital resources sooner than we expect.
We expect to incur expenses and operating losses for the foreseeable future as we continue to treat patients currently enrolled in our Phase 1 combination study with capecitabine or gemcitabine and as we plan and execute the liquidation and dissolution of the Company.
We are unable to estimate the exact amount of our working capital requirements. Our future capital requirements will depend on many factors, including:
•the wind down, timing, costs and results of our ongoing clinical trial of CYT-0851;
•the outcome, timing and cost of meeting regulatory requirements established by the FDA in connection with the wind down of our clinical trial of CYT-0851;
•the cost of expanding, maintaining, protecting and enforcing our intellectual property portfolio, including filing, prosecuting, defending and enforcing our patent claims and other intellectual property rights;
•the cost of defending potential intellectual property disputes, including patent infringement actions brought by third parties against us or any of our drug candidates;
•the costs of the planning and execution of the liquidation and dissolution of the Company; and
•the ongoing costs of operating as a public company.
20
Cash flows
The following table summarizes our cash flows for each of the periods presented:
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
(in thousands) |
|
2023 |
|
|
2022 |
|
Net cash used in operating activities |
|
$ |
(18,872 |
) |
|
$ |
(35,615 |
) |
Net cash provided (used) in investing activities |
|
|
303 |
|
|
|
(312 |
) |
Net cash provided by financing activities |
|
|
695 |
|
|
|
95 |
|
Net decrease in cash, cash equivalents and restricted cash |
|
$ |
(17,874 |
) |
|
$ |
(35,832 |
) |
Operating activities
Net cash used in operating activities for the nine months ended September 30, 2023 was $18.9 million, compared to $35.6 million for the same period in 2022. Significant factors in the $16.7 million decrease in net cash used in operating activities include:
•a decrease in net loss of $12.9 million primarily driven by a decrease in research and development expense of $9.8 million, general and administrative expenses of $0.2 million and an increase of total other income of $3.0 million;
•a decrease in non-cash charges of $1.3 million, consisting of a $1.4 million decrease in stock-based compensation expense, $0.4 million decrease in lease expense, $0.1 million decrease in depreciation and amortization expense and a $0.3 million gain on lease termination and modification offset by a $0.9 million increase from loss on disposal of property and equipment; offset by
•an increase in net change of $5.2 million in our net operating assets and liabilities, primarily due to a $4.8 million increase in accrued expenses and other current liabilities and a $0.9 million decrease in prepaids and other current assets offset by a $0.5 million decrease in accounts payable.
Investing activities
Net cash used by investing activities for the nine months ended September 30, 2023 and 2022 was immaterial due to $0.3 million purchases of property and equipment offset by proceeds of $0.3 million from the sale of property and equipment.
Financing activities
Net cash provided by financing activities for the nine months ended September 30, 2023 was $0.7 million, consisting of $0.1 million proceeds from issuance of common stock under our ESPP and $0.6 million proceeds from exercise of stock options.
Critical accounting estimates
Our management’s discussion and analysis of financial condition and results of operations is based on our consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States. The preparation of our consolidated financial statements and related disclosures requires us to make judgments, estimates and assumptions that affect the reported amounts of assets and liabilities, costs and expenses and the disclosure of contingent assets and liabilities in our financial statements.
We base our estimates on historical experience, known trends and events and various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. We evaluate our estimates and assumptions on an ongoing basis. Our actual results may differ from these estimates under different assumptions or conditions.
There have been no significant changes to our critical accounting policies from those described in “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” included in our Annual Report on Form 10-K for the year ended December 31, 2022. If our shareholders approve the Plan of Dissolution and the likelihood is remote that the Company would return from liquidation, we would consider liquidation as imminent and implement liquidation basis of accounting.
21
Emerging growth company status
We are an “emerging growth company”, or EGC, under the Jumpstart Our Business Startups Act of 2012, or the JOBS Act. Section 107 of the JOBS Act provides that an EGC can take advantage of the extended transition period provided in Section 7(a)(2)(B) of the Securities Act of 1933, as amended, for complying with new or revised accounting standards. Thus, an EGC can delay the adoption of certain accounting standards until those standards would otherwise apply to private companies. We have elected to avail ourselves of delayed adoption of new or revised accounting standards and, therefore, we will be subject to the same requirements to adopt new or revised accounting standards as private entities.
As an EGC, we have elected to take advantage of certain exemptions and reduced reporting requirements under the JOBS Act. Subject to certain conditions, as an EGC:
•we may present only two years of audited financial statements and only two years of related Management’s Discussion and Analysis of Financial Condition and Results of Operations;
•we may avail ourselves of the exemption from providing an auditor’s attestation report on our system of internal controls over financial reporting pursuant to Section 404(b) of the Sarbanes-Oxley Act;
•we may avail ourselves of the exemption from complying with any requirement that may be adopted by the Public Company Accounting Oversight Board, or PCAOB, regarding mandatory audit firm rotation or a supplement to the auditor’s report providing additional information about the audit and the financial statements, known as the auditor discussion and analysis;
• we may provide reduced disclosure about our executive compensation arrangements; and
•we may not require nonbinding advisory votes on executive compensation or stockholder approval of any golden parachute payments.
We will remain an EGC until the earliest of (i) the last day of the fiscal year following the fifth anniversary of the completion of our IPO, (ii) the last day of the fiscal year in which we have total annual gross revenues of $1.235 billion or more, (iii) the date on which we have issued more than $1.0 billion in non-convertible debt during the previous rolling three-year period or (iv) the date on which we are deemed to be a large accelerated filer under the Securities Exchange Act of 1934, as amended, or the Exchange Act.
We are also a “smaller reporting company,” meaning that the market value of our stock held by non-affiliates is less than $700 million and our annual revenue was less than $100 million during the most recently completed fiscal year. We may continue to be a smaller reporting company if either (i) the market value of our stock held by non-affiliates is less than $250 million or (ii) our annual revenue was less than $100 million during the most recently completed fiscal year and the market value of our stock held by non-affiliates is less than $700 million. If we are a smaller reporting company at the time we cease to be an emerging growth company, we may continue to rely on exemptions from certain disclosure requirements that are available to smaller reporting companies. Specifically, as a smaller reporting company we may choose to present only the two most recent fiscal years of audited financial statements in our Annual Report on Form 10-K and, similar to emerging growth companies, smaller reporting companies have reduced disclosure obligations regarding executive compensation.
22
Item 3. Quantitative and Qualitative Disclosures About Market Risk.
Interest rate risk
Our primary exposure to market risk is interest rate sensitivity, which is impacted by changes to the general level of U.S. interest rates, particularly because our cash equivalents are in the form of money market funds that are invested in U.S. Treasury securities. As of September 30, 2023 and December 31, 2022, we had cash, cash equivalents and restricted cash of $129.5 million and $149.4 million, respectively. Interest income is sensitive to changes in the general level of interest rates; however, due to the nature of these investments, an immediate 10% change in interest rates would not have a material effect on the fair market value of our investment portfolio.
As of September 30, 2023 and December 31, 2022, we had no debt outstanding, and therefore we are not subject to interest rate risk related to debt.
Foreign currency exchange risk
We are not currently exposed to significant market risk related to changes in foreign currency exchange rates.
Item 4. Controls and Procedures.
Evaluation of Disclosure Controls and Procedures
Our management, with the participation of our President and Chief Executive Officer and our Chief Financial Officer (our principal executive officer and principal financial officer, respectively), evaluated the effectiveness of our disclosure controls and procedures as of September 30, 2023. The term "disclosure controls and procedures," as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC's rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclose by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company's management, including its principal executive and principal financial officers, as appropriate to allow timely decisions regarding required disclosure. Management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation of our disclosure controls and procedures as of September 30, 2023, our principal executive officer and principal financial officer concluded that, as of such date, our disclosure controls and procedures were effective at the reasonable assurance level.
Changes in Internal Control over Financial Reporting
No change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) occurred during the fiscal three months ended September 30, 2023 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.
23
PART II—OTHER INFORMATION
Item 1. Legal Proceedings.
From time to time, we may become involved in litigation or other legal proceedings. We are not currently a party to any litigation or legal proceedings that, in the opinion of our management, are probable to have a material adverse effect on our business. Regardless of outcome, litigation can have an adverse impact on our business, financial condition, results of operations and prospects because of defense and settlement costs, diversion of management resources and other factors.
Item 1A. Risk Factors.
Investing in our common stock involves a high degree of risk. You should carefully consider the risks and uncertainties described in the section titled "Risk Factors" in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 together with all of the other information contained in this Quarterly Report on Form 10-Q, including the additional risk factors below and our consolidated financial statements and related notes appearing in this Quarterly Report on Form 10-Q, before deciding to invest in our common stock.
To the extent our liabilities, other obligations and expenses or claims against us are higher than we currently anticipate or larger contingency reserves are established, the amount available for distribution to our stockholders will be diminished.
As of September 30, 2023, we had $129.2 million in cash and cash equivalents. We expect to establish a reserve in connection with a Plan of Liquidation and Dissolution, or Plan of Dissolution, to be approved by our Board of Directors, which will be used to pay all expenses, including operating expenses up until the filing of the certificate of dissolution, or the Certificate of Dissolution, and other known, non-contingent liabilities, and which also includes reasonable provision for expenses of liquidation and potential, contingent and unknown liabilities as required by Delaware law. The amount of cash ultimately distributed to our stockholders in the liquidating distributions depends on the amount of our liabilities, obligations and expenses and claims against us, and contingency reserves that we establish during the liquidation process. While we will attempt to estimate reasonable reserves for such liabilities, obligations, expenses and claims against us, those estimates may be inaccurate. Factors that could impact our estimates include the following:
•if any of the estimates regarding the Plan of Dissolution, including the expenses to satisfy outstanding obligations, liabilities and claims during the liquidation process, are inaccurate;
•if unforeseen claims are asserted against us, we will have to defend or resolve such claims or establish a reasonable reserve before making distributions; and
•if the estimates regarding the expenses to be incurred in the liquidation process, including expenses of personnel required and other operating expenses (including legal, accounting and other professional fees) necessary to dissolve and liquidate Cyteir, are inaccurate.
If any of the foregoing occurs, the amount we distribute to our stockholders may be substantially less.
We may not be successful in selling our clinical assets and programs, which would limit the amount of cash available to distribute to our stockholders.
We may sell our remaining clinical assets and programs and expect to continue pursuing the Plan of Dissolution in the near term. We may have significant expenses in connection with sale of our clinical assets and programs, which expenses will decrease the remaining cash available for use in our business and may diminish or delay any distributions to our stockholders in connection with the Plan of Dissolution.
The exact amount or timing of any liquidating distributions to our stockholders under the Plan of Dissolution is uncertain.
The precise amount and timing of any liquidating distribution to our stockholders will depend on and could be delayed by, among other things, sales of our remaining non-cash assets, any unexpected claims from third parties, including governmental authorities, and unexpected or greater than expected expenses.
Although our Board of Directors has not established a firm timetable for liquidating distributions to our stockholders, assuming our stockholders approve the Plan of Dissolution, the Board of Directors intends, subject to contingencies inherent in winding down our business, to make such liquidating distributions, if any, as promptly as practicable as creditor claims and contingent liabilities are paid or settled. However, we are currently unable to predict the precise timing of any such liquidating distributions or whether any liquidating distributions will occur at all. Additionally, a creditor could seek an
24
injunction against the making of such distributions to our stockholders on the ground that the amounts to be distributed were needed to provide for the payment of our liabilities and expenses. Any action of this type could delay or substantially diminish the amount available for such distribution to our stockholders.
If we fail to create an adequate contingency reserve for payment of our expenses and liabilities, any stockholder receiving liquidating distributions could be held liable for payment to our creditors of their pro rata share of amounts owed to creditors in excess of the contingency reserve, up to the amount actually distributed to such stockholder in dissolution.
If the Plan of Dissolution is approved by our stockholders, we will file the Certificate of Dissolution with the Delaware Secretary of State dissolving Cyteir Therapeutics, Inc. Pursuant to the Delaware General Corporation Law, or the DGCL, we will continue to exist for three years after our dissolution or for such longer period as the Delaware Court of Chancery shall direct, for the purpose of prosecuting and defending suits against us and enabling us gradually to close our business, to dispose of our property, to discharge our liabilities, to conduct an orderly wind down of our clinical trial and to distribute to our stockholders any remaining assets. Under the DGCL, in the event we fail to create an adequate contingency reserve for payment of our expenses and liabilities, each stockholder of record as of the date of the filing of the Certificate of Dissolution, which is referred to hereinafter as the final record date, could be held liable for payment to our creditors of such stockholder’s pro rata share of amounts owed to creditors in excess of the contingency reserve, up to the amount actually distributed to such stockholder in dissolution.
Although the liability of any stockholder is limited to the amounts previously received by such stockholder from us pursuant to the Plan of Dissolution, this means that a stockholder could be required to return all liquidating distributions previously made to such stockholder and receive nothing from us under the Plan of Dissolution. Moreover, in the event a stockholder has paid taxes on amounts previously received, a repayment of all or a portion of such amount could result in a stockholder incurring a net tax cost if the stockholder’s repayment of an amount previously distributed does not cause a commensurate reduction in taxes payable. While we will endeavor to make adequate reserves for all known, contingent, and unknown liabilities, there is no guarantee that the reserves established by us will be adequate to cover all such expenses and liabilities.
Our stock transfer books will be closed at the close of business on the date we file the Certificate of Dissolution with the Delaware Secretary of State, after which it will not be possible for stockholders to publicly trade our stock.
On the date we file the Certificate of Dissolution with the Delaware Secretary of State, we intend to close our stock transfer books and discontinue recording transfers of our common stock. Thereafter, certificates or book entries representing our common stock will not be assignable or transferable on our books except by will, intestate succession or operation of law. The proportionate interests of all of our stockholders will be fixed on the basis of their respective stock holdings at the close of business on the final record date, and, after such date, any distributions made by us will be made solely to the stockholders of record at the close of business on the final record date, except as may be necessary to reflect subsequent transfers recorded on our books as a result of any assignments by will, intestate succession or operation of law.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
Use of Proceeds
On June 22, 2021, we completed our IPO pursuant to which we issued and sold 7,400,000 shares of our common stock at a public offering price of $18.00 per share. On July 1, 2021, we sold an additional 885,644 shares of our common stock at a public offering price of $18.00 per share. The offer and sale of all of our common shares were registered under the Securities Act pursuant to a registration statement on Form S-1, as amended (File No. 333-256601), which was declared effective by the SEC on June 17, 2021.
Our planned use of the net proceeds from the IPO as described in our final prospectus dated June 17, 2021 has changed due to our planned liquidation and dissolution. As a result, we currently expect to use our cash and cash equivalents, which include the net proceeds from our IPO, to conduct and orderly wind down of our business, including a wind down of our clinical trial of CYT-0851. We intend to distribute any remaining cash to our stockholders, in accordance with a Plan of Dissolution.
Item 3. Defaults Upon Senior Securities.
None.
25
Item 4. Mine Safety Disclosures.
Not applicable.
Item 5. Other Information.
None.
26
Item 6. Exhibits.
* Filed herewith.
** Furnished herewith.
+ Indicates management contract or compensatory plan or arrangement.
27
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on
its behalf by the undersigned thereunto duly authorized.
|
|
|
|
|
|
Cyteir Therapeutics, Inc. |
|
|
|
|
Date: November 6, 2023 |
|
By: |
/s/ Markus Renschler |
|
|
|
Markus Renschler, M.D. |
|
|
|
President and Chief Executive Officer (Principal Executive Officer) |
|
|
|
|
Date: November 6, 2023 |
|
By: |
/s/ David Gaiero |
|
|
|
David Gaiero |
|
|
|
Chief Financial Officer and Treasurer (Principal Financial Officer) |
28
Exhibit 31.1
CERTIFICATION PURSUANT TO
RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934,
AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, Markus Renschler, M.D., certify that:
1.I have reviewed this Quarterly Report on Form 10-Q of Cyteir Therapeutics, Inc.;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c)Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d)Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and
5.The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):
(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and
(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.
|
|
|
|
Date: November 6, 2023 |
|
By: |
/s/ Markus Renschler |
|
|
|
Markus Renschler, M.D. |
|
|
|
President and Chief Executive Officer (Principal Executive Officer) |
Exhibit 31.2
CERTIFICATION PURSUANT TO
RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934,
AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, David Gaiero, certify that:
1.I have reviewed this Quarterly Report on Form 10-Q of Cyteir Therapeutics, Inc.;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c)Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d)Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and
5.The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):
(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and
(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.
|
|
|
|
Date: November 6, 2023 |
|
By: |
/s/ David Gaiero |
|
|
|
David Gaiero |
|
|
|
Chief Financial Officer and Treasurer (Principal Financial Officer) |
Exhibit 32.1
CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report of Cyteir Therapeutics, Inc. (the “Company”) on Form 10-Q for the period ending September 30, 2023 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:
(1)The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
|
|
|
|
Date: November 6, 2023 |
|
By: |
/s/ Markus Renschler |
|
|
|
Markus Renschler, M.D. |
|
|
|
President and Chief Executive Officer (Principal Executive Officer) |
Exhibit 32.2
CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report of Cyteir Therapeutics, Inc. (the “Company”) on Form 10-Q for the period ending September 30, 2023 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:
(1)The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
|
|
|
|
Date: November 6, 2023 |
|
By: |
/s/ David Gaiero |
|
|
|
David Gaiero |
|
|
|
Chief Financial Officer and Treasurer (Principal Financial Officer) |
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v3.23.3
Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands |
Sep. 30, 2023 |
Dec. 31, 2022 |
Current assets: |
|
|
Cash and cash equivalents |
$ 129,242
|
$ 147,120
|
Prepaid expenses and other current assets |
1,401
|
2,089
|
Total current assets |
130,643
|
149,209
|
Property and equipment, net |
105
|
1,699
|
Other assets |
261
|
2,324
|
Total assets |
131,009
|
153,232
|
Current liabilities: |
|
|
Accounts payable |
508
|
1,128
|
Accrued expenses and other current liabilities |
5,461
|
4,187
|
Total current liabilities |
5,969
|
5,315
|
Other long term liabilities |
9
|
1,631
|
Total liabilities |
5,978
|
6,946
|
Commitments and Contingencies (Note 10) |
|
|
Stockholders' equity: |
|
|
Preferred stock, $0.001 par value: 40,000,000 shares authorized as of September 30, 2023 and December 31, 2022; no shares issued and outstanding as of September 30, 2023 and December 31, 2022 |
|
|
Common stock, $0.001 par value: 280,000,000 shares authorized as of September 30, 2023 and December 31, 2022; 36,091,075 and 35,575,694 shares issued as of September 30, 2023 and December 31, 2022, respectively; 36,083,742 and 35,516,249 shares outstanding as of September 30, 2023 and December 31, 2022, respectively |
35
|
35
|
Additional paid-in capital |
287,532
|
284,365
|
Accumulated deficit |
(162,536)
|
(138,114)
|
Total stockholders' equity |
125,031
|
146,286
|
Total liabilities and stockholders' equity |
$ 131,009
|
$ 153,232
|
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v3.23.3
Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - $ / shares
|
Sep. 30, 2023 |
Dec. 31, 2022 |
Preferred stock, par value |
$ 0.001
|
$ 0.001
|
Preferred stock, shares authorized |
40,000,000
|
40,000,000
|
Preferred stock, shares issued |
0
|
0
|
Preferred stock, shares outstanding |
0
|
0
|
Common stock, par value |
$ 0.001
|
$ 0.001
|
Common stock, shares authorized |
280,000,000
|
280,000,000
|
Common stock, shares issued |
36,091,075
|
35,575,694
|
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36,083,742
|
35,516,249
|
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v3.23.3
Condensed Consolidated Statements of Operations (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Operating expenses: |
|
|
|
|
Research and development |
$ 2,676
|
$ 8,272
|
$ 17,391
|
$ 27,154
|
General and administrative |
2,495
|
3,487
|
10,809
|
10,963
|
Total operating expenses |
5,171
|
11,759
|
28,200
|
38,117
|
Loss from operations |
(5,171)
|
(11,759)
|
(28,200)
|
(38,117)
|
Other income (expense): |
|
|
|
|
Interest income |
1,639
|
714
|
4,385
|
849
|
Loss on disposal of property and equipment |
|
|
(925)
|
|
Gain on lease terminations and modification |
|
|
318
|
|
Total other income (expense) |
1,639
|
714
|
3,778
|
849
|
Net loss |
$ (3,532)
|
$ (11,045)
|
$ (24,422)
|
$ (37,268)
|
Net loss per share--basic |
$ (0.10)
|
$ (0.31)
|
$ (0.68)
|
$ (1.06)
|
Net loss per share--diluted |
$ (0.10)
|
$ (0.31)
|
$ (0.68)
|
$ (1.06)
|
Weighted-average common stock outstanding--basic |
36,030,474
|
35,329,137
|
35,647,202
|
35,283,454
|
Weighted-average common stock outstanding--diluted |
36,030,474
|
35,329,137
|
35,647,202
|
35,283,454
|
X |
- DefinitionThe amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.
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v3.23.3
Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($) $ in Thousands |
Total |
Common Stock |
Additional Paid-in Capital |
Accumulated Deficit |
Balance at Dec. 31, 2021 |
$ 187,292
|
$ 35
|
$ 279,310
|
$ (92,053)
|
Balance, Shares at Dec. 31, 2021 |
|
35,219,834
|
|
|
Exercise of common stock options |
19
|
|
19
|
|
Exercise of common stock options, Shares |
|
19,575
|
|
|
Vesting of early exercised options |
39
|
|
39
|
|
Vesting of early exercised options, Shares |
|
32,605
|
|
|
Stock-based compensation expense |
1,255
|
|
1,255
|
|
Net loss |
(14,102)
|
|
|
(14,102)
|
Balance at Mar. 31, 2022 |
174,503
|
$ 35
|
280,623
|
(106,155)
|
Balance, Shares at Mar. 31, 2022 |
|
35,272,014
|
|
|
Balance at Dec. 31, 2021 |
187,292
|
$ 35
|
279,310
|
(92,053)
|
Balance, Shares at Dec. 31, 2021 |
|
35,219,834
|
|
|
Net loss |
(37,268)
|
|
|
|
Balance at Sep. 30, 2022 |
154,033
|
$ 35
|
283,319
|
(129,321)
|
Balance, Shares at Sep. 30, 2022 |
|
35,354,141
|
|
|
Balance at Mar. 31, 2022 |
174,503
|
$ 35
|
280,623
|
(106,155)
|
Balance, Shares at Mar. 31, 2022 |
|
35,272,014
|
|
|
Exercise of common stock options |
5
|
|
5
|
|
Exercise of common stock options, Shares |
|
4,398
|
|
|
Vesting of early exercised options |
32
|
|
32
|
|
Vesting of early exercised options, Shares |
|
26,732
|
|
|
Stock-based compensation expense |
1,365
|
|
1,365
|
|
Net loss |
(12,121)
|
|
|
(12,121)
|
Balance at Jun. 30, 2022 |
163,784
|
$ 35
|
282,025
|
(118,276)
|
Balance, Shares at Jun. 30, 2022 |
|
35,303,144
|
|
|
Exercise of common stock options |
7
|
|
7
|
|
Exercise of common stock options, Shares |
|
6,112
|
|
|
Vesting of early exercised options |
30
|
|
30
|
|
Vesting of early exercised options, Shares |
|
25,511
|
|
|
Issuance of common stock under ESPP |
64
|
|
64
|
|
Issuance of common stock under ESPP, Shares |
|
19,374
|
|
|
Stock-based compensation expense |
1,193
|
|
1,193
|
|
Net loss |
(11,045)
|
|
|
(11,045)
|
Balance at Sep. 30, 2022 |
154,033
|
$ 35
|
283,319
|
(129,321)
|
Balance, Shares at Sep. 30, 2022 |
|
35,354,141
|
|
|
Balance at Dec. 31, 2022 |
146,286
|
$ 35
|
284,365
|
(138,114)
|
Balance, Shares at Dec. 31, 2022 |
|
35,516,249
|
|
|
Exercise of common stock options |
42
|
|
42
|
|
Exercise of common stock options, Shares |
|
41,588
|
|
|
Vesting of early exercised options |
31
|
|
31
|
|
Vesting of early exercised options, Shares |
|
25,144
|
|
|
Issuance of common stock under ESPP |
61
|
|
61
|
|
Issuance of common stock under ESPP, Shares |
|
41,146
|
|
|
Stock-based compensation expense |
1,042
|
|
1,042
|
|
Net loss |
(12,486)
|
|
|
(12,486)
|
Balance at Mar. 31, 2023 |
134,976
|
$ 35
|
285,541
|
(150,600)
|
Balance, Shares at Mar. 31, 2023 |
|
35,624,127
|
|
|
Balance at Dec. 31, 2022 |
$ 146,286
|
$ 35
|
284,365
|
(138,114)
|
Balance, Shares at Dec. 31, 2022 |
|
35,516,249
|
|
|
Exercise of common stock options, Shares |
457,579
|
|
|
|
Net loss |
$ (24,422)
|
|
|
|
Balance at Sep. 30, 2023 |
125,031
|
$ 35
|
287,532
|
(162,536)
|
Balance, Shares at Sep. 30, 2023 |
|
36,083,742
|
|
|
Balance at Mar. 31, 2023 |
134,976
|
$ 35
|
285,541
|
(150,600)
|
Balance, Shares at Mar. 31, 2023 |
|
35,624,127
|
|
|
Exercise of common stock options |
428
|
|
428
|
|
Exercise of common stock options, Shares |
|
351,879
|
|
|
Vesting of early exercised options |
11
|
|
11
|
|
Vesting of early exercised options, Shares |
|
16,517
|
|
|
Stock-based compensation expense |
776
|
|
776
|
|
Net loss |
(8,404)
|
|
|
(8,404)
|
Balance at Jun. 30, 2023 |
127,787
|
$ 35
|
286,756
|
(159,004)
|
Balance, Shares at Jun. 30, 2023 |
|
35,992,523
|
|
|
Exercise of common stock options |
133
|
|
133
|
|
Exercise of common stock options, Shares |
|
64,112
|
|
|
Vesting of early exercised options |
14
|
|
14
|
|
Vesting of early exercised options, Shares |
|
5,501
|
|
|
Issuance of common stock under ESPP |
30
|
|
30
|
|
Issuance of common stock under ESPP, Shares |
|
21,606
|
|
|
Stock-based compensation expense |
599
|
|
599
|
|
Net loss |
(3,532)
|
|
|
(3,532)
|
Balance at Sep. 30, 2023 |
$ 125,031
|
$ 35
|
$ 287,532
|
$ (162,536)
|
Balance, Shares at Sep. 30, 2023 |
|
36,083,742
|
|
|
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v3.23.3
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Cash flows from operating activities: |
|
|
|
|
Net loss |
|
|
$ (24,422)
|
$ (37,268)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
Depreciation and amortization expense |
$ 100
|
$ 200
|
368
|
498
|
Stock-based compensation |
599
|
1,193
|
2,417
|
3,813
|
Non-cash lease expense |
|
|
158
|
551
|
Loss on disposal of property and equipment |
|
|
925
|
|
Gain on lease terminations and modification |
|
|
(318)
|
|
Changes in operating assets and liabilities: |
|
|
|
|
Prepaid expenses and other current assets |
|
|
686
|
(179)
|
Accounts payable |
|
|
(620)
|
(119)
|
Accrued expenses and other current liabilities |
|
|
1,940
|
(2,912)
|
Other long term liabilities |
|
|
(6)
|
1
|
Net cash used in operating activities |
|
|
(18,872)
|
(35,615)
|
Cash flows from investing activities: |
|
|
|
|
Purchases of property and equipment |
|
|
|
(312)
|
Proceeds from sales of property and equipment |
|
|
303
|
|
Net cash provided by (used) in investing activities |
|
|
303
|
(312)
|
Cash flows from financing activities: |
|
|
|
|
Proceeds from issuance of common stock under ESPP |
|
|
92
|
64
|
Proceeds from exercise of stock options |
|
|
603
|
31
|
Net cash provided by financing activities |
|
|
695
|
95
|
Net decrease in cash, cash equivalents, and restricted cash |
|
|
(17,874)
|
(35,832)
|
Cash, cash equivalents and restricted cash at beginning of period |
|
|
147,377
|
189,979
|
Cash, cash equivalents and restricted cash at end of period |
129,503
|
154,147
|
129,503
|
154,147
|
Supplemental disclosure of cash flows |
|
|
|
|
Remeasurement of operating lease liabilities and right-of-use assets due to lease modification |
|
|
(1,908)
|
|
Vesting of early exercised options |
|
|
56
|
101
|
Reconciliation of cash, cash equivalents and restricted cash |
|
|
|
|
Cash and cash equivalents |
129,242
|
153,890
|
129,242
|
153,890
|
Restricted cash (included in other assets) |
$ 261
|
$ 257
|
$ 261
|
$ 257
|
Restricted Cash and Cash Equivalents, Noncurrent, Statement of Financial Position [Extensible Enumeration] |
Other Assets, Noncurrent
|
Other Assets, Noncurrent
|
Other Assets, Noncurrent
|
Other Assets, Noncurrent
|
Total cash, cash equivalents, and restricted cash |
$ 129,503
|
$ 154,147
|
$ 129,503
|
$ 154,147
|
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v3.23.3
Nature of the Business
|
9 Months Ended |
Sep. 30, 2023 |
Accounting Policies [Abstract] |
|
Nature Of the Business |
1. Nature of the business On June 30, 2023, Cyteir Therapeutics, Inc., (the “Company”) announced the discontinuation of development of CYT-0851, its investigational monocarboxylate transporter inhibitor, and that the Company would initiate a plan to liquidate its assets following an orderly wind down of the Company’s operations, and return remaining cash to shareholders. On September 7, 2023, the Board of Directors of the Company unanimously approved, subject to stockholder approval, the liquidation and dissolution of the Company pursuant to a plan of liquidation and dissolution (the “Plan of Dissolution”) that includes the distribution of remaining cash to stockholders following an orderly wind down of the Company’s operations, including the proceeds, if any, from the sale of its assets. Prior to winding down operations, the Company intends to complete regulatory and patient obligations from the ongoing clinical trial. The Company has engaged independent advisors, who are experienced in the dissolution and liquidation of companies, to assist in the Company’s dissolution and liquidation. The Company has called a special meeting of its stockholders on November 16, 2023 to seek approval of the Plan of Dissolution and filed definitive proxy materials relating to the special meeting with the Securities and Exchange Commission (the “SEC”) on October 12, 2023. If the Company’s stockholders approve the Plan of Dissolution and the likelihood is remote that the Company would return from liquidation, the Company would consider liquidation as imminent and implement liquidation basis of accounting. CYT-0851 was being evaluated in a Phase 1 combination study with capecitabine or gemcitabine in advanced ovarian cancer and other solid tumors. The Company will continue to treat patients currently enrolled in the Company’s Phase 1/2 study of CYT-0851 as a monotherapy and in a combination study with capecitabine or gemcitabine until the conclusion of the study. Through 2022, the Company used its expertise in DNA damage response biology and a disciplined approach to select targets for other novel, differentiated programs with the aim of building a patient-centric portfolio of effective cancer therapies. In January 2023, the Company announced a strategic prioritization that included the discontinuation of these preclinical efforts. The Company was formed as a Delaware corporation on June 4, 2012, pursuant to the General Corporation Law of the State of Delaware. The Company has a principal office in Lexington, Massachusetts. Liquidity The Company has incurred net operating losses since inception and has funded its operations primarily with proceeds from the sale of redeemable convertible preferred stock and the issuance of common stock in its initial public offering, or IPO. As of September 30, 2023, the Company had cash and cash equivalents of $129.2 million and an accumulated deficit of $162.5 million. The Company expects its operating losses and negative operating cash flows to continue into the foreseeable future. The Company expects that its cash and cash equivalents as of September 30, 2023 will be sufficient to fund its operating expenses and capital expenditure requirements for at least twelve months from the date these condensed consolidated financial statements are available to be issued, or until the effectiveness of the Company’s dissolution.
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v3.23.3
Summary of Significant Accounting Policies
|
9 Months Ended |
Sep. 30, 2023 |
Accounting Policies [Abstract] |
|
Summary of Significant Accounting Policies |
2. Summary of significant accounting policies The Company's significant accounting policies are disclosed in the audited consolidated financial statements for the years ended December 31, 2022 and 2021 ("audited financial statements"), which are included in the Company's Annual Report on Form 10-K that was filed with the SEC on March 23, 2023. Since the date of the financial statements, there have been no changes to the Company's significant accounting policies, except as noted below. Interim Financial Information The accompanying condensed consolidated balance sheet at September 30, 2023, and the condensed consolidated statements of operations, statements of changes in stockholders’ equity for the three and nine months ended September 30, 2023 and 2022 and condensed consolidated statements of cash flows for the nine months ended September 30, 2023 and 2022 are unaudited. The condensed consolidated interim financial statements have been prepared on the same basis as the audited annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments necessary for the fair presentation of the Company’s financial position at September 30, 2023 and the results of its operations for the three and nine months ended September 30, 2023 and 2022 and its cash flows for the nine months ended September 30, 2023 and 2022. The financial data and other information disclosed in these notes related to the three and nine months ended September 30, 2023 and 2022 are also unaudited. The results for the three and nine months ended September 30, 2023 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.
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- DefinitionThe entire disclosure for all significant accounting policies of the reporting entity.
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v3.23.3
Fair Value Measurement
|
9 Months Ended |
Sep. 30, 2023 |
Fair Value Disclosures [Abstract] |
|
Fair Value Measurement |
3. Fair value measurement The following tables present information about the Company’s financial assets and liabilities measured at fair value on a recurring basis (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
Assets: |
|
Total |
|
|
Quoted prices in active markets for identical assets (level 1) |
|
|
Significant other observable inputs (level 2) |
|
|
Significant other observable inputs (level 3) |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
128,954 |
|
|
$ |
128,954 |
|
|
$ |
— |
|
|
$ |
— |
|
Total assets |
|
$ |
128,954 |
|
|
$ |
128,954 |
|
|
$ |
|
|
|
$ |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2022 |
|
Assets |
|
Total |
|
|
Quoted prices in active markets for identical assets (level 1) |
|
|
Significant other observable inputs (level 2) |
|
|
Significant other observable inputs (level 3) |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
146,870 |
|
|
$ |
146,870 |
|
|
$ |
— |
|
|
$ |
— |
|
Total assets |
|
$ |
146,870 |
|
|
$ |
146,870 |
|
|
$ |
— |
|
|
$ |
— |
|
During the nine months ended September 30, 2023 and the year ended December 31, 2022, there were no transfers between levels. The fair values of the Company’s cash equivalents, consisting of its standard checking accounts and money market funds, are based on quoted market prices in active markets without any valuation adjustment. The Company uses the carrying amounts of its restricted cash, prepaid expenses and other current assets, accounts payable and accrued expenses and other current liabilities to approximate their fair value due to the short-term nature of these amounts.
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- DefinitionThe entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.
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v3.23.3
X |
- DefinitionPrepaid expenses and other current assets.
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v3.23.3
Property and Equipment, Net
|
9 Months Ended |
Sep. 30, 2023 |
Property, Plant and Equipment [Abstract] |
|
Property and Equipment, Net |
5. Property and equipment, net On January 19, 2023, the Company announced a strategic prioritization of clinical development of CYT-0851, which included the discontinuation of preclinical efforts and a workforce reduction by approximately 70% of the Company's workforce. For the nine months ended September 30, 2023, the Company recognized a loss on disposal of property and equipment totaling $0.9 million on the Company's condensed consolidated statement of operations. Property and equipment, net consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
Acquisition cost |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
1,846 |
|
|
$ |
1,675 |
|
|
$ |
3,521 |
|
Disposals |
|
|
(1,752 |
) |
|
|
(1,266 |
) |
|
|
(3,018 |
) |
As of September 30, 2023 |
|
$ |
94 |
|
|
$ |
409 |
|
|
$ |
503 |
|
|
|
|
|
|
|
|
|
|
|
Accumulated depreciation and amortization |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
(827 |
) |
|
$ |
(995 |
) |
|
$ |
(1,822 |
) |
Depreciation expense |
|
|
(63 |
) |
|
|
(305 |
) |
|
|
(368 |
) |
Disposals |
|
|
866 |
|
|
|
926 |
|
|
|
1,792 |
|
As of September 30, 2023 |
|
$ |
(24 |
) |
|
$ |
(374 |
) |
|
$ |
(398 |
) |
|
|
|
|
|
|
|
|
|
|
Carrying amount |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
1,019 |
|
|
$ |
680 |
|
|
$ |
1,699 |
|
As of September 30, 2023 |
|
$ |
70 |
|
|
$ |
35 |
|
|
$ |
105 |
|
For the three months ended September 30, 2023 and 2022, depreciation and amortization expense related to property and equipment was $0.1 million and $0.2 million, respectively. For the nine months ended September 30, 2023 and 2022, depreciation and amortization expense related to property and equipment was $0.4 million and $0.5 million, respectively.
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v3.23.3
Accrued Expenses and Other Current Liabilities
|
9 Months Ended |
Sep. 30, 2023 |
Payables and Accruals [Abstract] |
|
Accrued Expenses and Other Current Liabilities |
6. Accrued expenses and other current liabilities Accrued expenses and other current liabilities consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Accrued research and development expenses |
|
$ |
1,646 |
|
|
$ |
1,356 |
|
Accrued compensation |
|
|
3,449 |
|
|
|
1,510 |
|
Accrued other |
|
|
350 |
|
|
|
432 |
|
Operating lease liabilities |
|
|
16 |
|
|
|
889 |
|
Total accrued expenses and other current liabilities |
|
$ |
5,461 |
|
|
$ |
4,187 |
|
|
X |
- DefinitionThe entire disclosure for accounts payable, accrued expenses, and other liabilities that are classified as current at the end of the reporting period.
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v3.23.3
Common Stock
|
9 Months Ended |
Sep. 30, 2023 |
Equity [Abstract] |
|
Common Stock |
7. Common stock The voting, dividend and liquidation rights of the holders of the Company’s common stock are subject to and qualified by the rights, powers and preferences of the holders of the preferred stock as set forth in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2022. The holders of the common stock are entitled to one vote for each share of common stock held submitted to a vote of stockholders, and there are not any cumulative voting rights. Holders of common stock are entitled to receive proportionately any dividends as may be declared by the Company's board of directors subject to any preferential dividend rights of any series of preferred stock that the Company may designate and issue in the future. As of September 30, 2023 and December 31, 2022, the Company has reserved the following shares of common stock for the potential exercise of stock options:
|
|
|
|
|
|
|
|
|
|
|
September 30, |
|
|
December 31, |
|
|
|
2023 |
|
|
2022 |
|
Options to purchase common stock |
|
|
2,672,831 |
|
|
|
3,460,897 |
|
Remaining shares reserved for future issuance |
|
|
7,820,567 |
|
|
|
5,706,345 |
|
Total |
|
|
10,493,398 |
|
|
|
9,167,242 |
|
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v3.23.3
Stock-based Compensation
|
9 Months Ended |
Sep. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Stock-based Compensation |
8. Stock-based compensation 2012 Stock Incentive Plan The Company adopted the 2012 Stock Incentive Plan (the “2012 Plan”) in November 2012 pursuant to which the Company can issue incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock awards, restricted stock unit awards and other stock awards. Recipients of stock options or stock appreciate rights shall be eligible to purchase shares of the Company’s common stock at an exercise price equal to the estimated fair market value of such stock on the date of grant. The exercise price may be less than fair market value if the stock award is granted pursuant to an assumption or substitution for another stock award in the event of a merger or sale of the Company. The maximum term of options granted under the 2012 Plan is ten years, and stock options typically vest over a four-year period. The Board may assign vesting terms to the stock option grants as deemed appropriate. The Company also has the right of refusal to purchase any proposed disposition of shares issued under the 2012 Plan. The 2012 Plan allows for early exercise of all stock option grants if authorized by the Board at the time of grant. The shares of common stock issued from the early exercise of stock options are restricted and vest over time. The Company has the option to repurchase any unvested shares at the original purchase price upon any voluntary or involuntary termination. At the discretion of the Board, unvested shares held by employees may accelerate vesting in the event of a change of control of the Company unless assumed or substituted by the acquirer or surviving entity. The 2012 Plan has been subsequently amended and provides for the issuance of up to 6,941,421 shares of common stock as of September 30, 2023, of which 2,732,632 shares of common stock remained available for future grant under the 2012 Plan upon the effectiveness of the 2021 Equity Incentive Plan (the “2021 Plan”) and were made available for future issuance under the 2021 Plan. 2021 Equity Incentive Plan In June 2021, the Company’s board of directors adopted and the Company’s stockholders approved the 2021 Plan, which became effective immediately prior to the effectiveness of the registration statement for the IPO. The 2021 Plan provides for the grant of incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock awards, restricted stock units and other stock-based awards. Upon effectiveness of the 2021 Plan, the number of shares of common stock reserved for issuance under the 2021 Plan was 5,932,632, which represents 3,200,000 shares along with 2,732,632 shares of common stock reserved for issuance under the 2012 Plan that remained available for grant under the 2012 Plan immediately prior to the effectiveness of the 2021 Plan. Shares of the Company's common stock subject to outstanding awards granted under the 2012 Plan that expire unexercised or are terminated, surrendered, cancelled, forfeited or repurchased by the Company at their original issuance price pursuant to a contractual repurchase right will become available for issuance under the 2021 Plan. Upon adoption of the 2021 Plan, the Company ceased the grant of additional awards under the 2012 Plan. The 2021 Plan includes an "evergreen" provision, which provides for an annual increase to be added on January 1st of each year beginning in 2022 and continuing through and including 2031 by the lesser of (i) 5% of the number of shares of Stock outstanding as of such date and (ii) an amount determined by the board of directors. On January 1, 2023, the number of shares of Common Stock reserved and available for issuance under the 2021 Plan increased by 1,778,784 shares. At September 30, 2023, 7,820,567 shares of common stock remained available for future grant under the 2021 Plan. 2021 Employee Stock Purchase Plan In June 2021, the Company’s board of directors adopted, and the Company’s stockholders approved, the 2021 Employee Stock Purchase Plan (the “ESPP”), which became effective immediately prior to the effectiveness of the registration statement for the IPO. The ESPP is administered by the compensation committee of the Company’s board of directors, except that the Company’s board of directors may at any time act as the administrator of the ESPP. On July 13, 2023, the Compensation Committee suspended all future purchases under the ESPP, effective as of July 14, 2023, such that no new ESPP option periods will commence after July 14, 2023. The ESPP provides participating employees with the opportunity to purchase shares of common stock, with an initial aggregate share pool of 300,000 shares of common stock. The number of shares of common stock reserved for issuance under the ESPP will automatically increase on January 1st of each year beginning in 2022 and continuing through and including 2031 by the least of (i) 1% of the number of shares of Stock outstanding as of such date, (ii) 600,000 shares of Stock and (iii) the number of shares of Stock determined by the Company’s board of directors on or prior to such date for such year, up to a maximum of 6,300,000 shares in the aggregate. On January 1, 2023, the number of shares of Common Stock reserved and available for issuance under the ESPP increased by 355,756 shares. The ESPP allows eligible employees to authorize payroll deductions of between 1% and 15% of their regular base salary or wages to be applied toward the purchase of shares of the Company's common stock on the last trading day of the offering period, subject to certain limitations contained in the ESPP. Participating employees will purchase shares of the Company's common stock at a discount of 15% on the lesser of the closing price of the Company's common stock on the Nasdaq Global Select Market (i) on the first trading day of the offering period or (ii) the last trading day of the offering period. The Company utilizes the Black Scholes option pricing model to compute the fair market value of the shares subject to outstanding options under the ESPP and compensation expense is recognized over the offering period. Participation in the ESPP is voluntary. Eligible employees become participants in the ESPP by enrolling in the plan and authorizing payroll deductions in accordance with the terms of the ESPP. At the end of each offering period, accumulated payroll deductions are used to purchase the Company’s shares at the discounted price. The Company makes no contributions to the ESPP. A participant may withdraw from the ESPP or reduce contributions to the ESPP during an offering period. If the participant elects to withdraw during an offering period, all contributions are refunded as soon as administratively practicable. If a participant elects to withdraw during an offering period, the participant may not re-enroll in the current offering but may elect to participate in future offerings, subject to the terms of the ESPP. Only whole shares of the Company may be purchased under the ESPP. The Company issued 62,754 common shares under the ESPP during the nine months ended September 30, 2023 at an average price per share of $1.45. Cash received from purchases under the ESPP for the nine months ended September 30, 2023 was $0.1 million. The Company recognized an immaterial amount of compensation expense for the ESPP during the nine months ended September 30, 2023. Early exercise of unvested stock options Shares purchased by employees pursuant to the early exercise of stock options are not deemed, for accounting purposes, to be outstanding shares until those shares vest according to their respective vesting schedules. Cash received from employee exercises of unvested options is included in long-term liabilities on the condensed consolidated balance sheets. Amounts recorded are reclassified to common stock and additional paid-in capital as the shares vest. As of September 30, 2023 and December 31, 2022, there were 7,333 and 59,445 unvested shares related to early exercises of stock options, respectively. Stock option valuation The assumptions that the Company used in the Black Scholes option-pricing model to determine the grant date fair value of stock options granted were as follows:
|
|
|
|
|
|
September 30, 2023 |
December 31, 2022 |
Risk-free interest rate range |
|
3.64-3.65% |
1.89%-4.23% |
Dividend yield |
|
0.0% |
0.0% |
Expected life of options (years) |
|
6.0 |
6.0 |
Volatility rate range |
|
93.0-93.3% |
92.4%-93.3% |
The following table summarizes the Company’s stock option activity during the nine months ended September 30, 2023:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average exercise price |
|
|
Weighted average remaining contractual term (in years) |
|
|
Aggregate intrinsic value (in thousands) |
|
Outstanding as of December 31, 2022 |
|
|
3,460,897 |
|
|
$ |
5.60 |
|
|
|
8.23 |
|
|
$ |
375 |
|
Granted |
|
|
1,054,357 |
|
|
$ |
1.69 |
|
|
|
— |
|
|
|
— |
|
Exercised |
|
|
(457,579 |
) |
|
$ |
1.32 |
|
|
|
— |
|
|
|
— |
|
Forfeited or cancelled |
|
|
(1,384,844 |
) |
|
$ |
5.55 |
|
|
|
— |
|
|
|
— |
|
Outstanding as of September 30, 2023 |
|
|
2,672,831 |
|
|
$ |
4.82 |
|
|
|
8.02 |
|
|
$ |
1,530 |
|
Options vested and exercisable as of September 30, 2023 |
|
|
1,439,617 |
|
|
$ |
6.04 |
|
|
|
7.37 |
|
|
$ |
575 |
|
As of September 30, 2023, there was $2.9 million of unrecognized stock-based compensation expense related to the share-based compensation arrangements under the 2012 Plan. The Company expects to recognize this amount over a weighted-average period of 2.3 years. The aggregate intrinsic value of options is calculated as the difference between the exercise price of the stock options and the fair value of the Company’s common stock for those stock options that had exercise prices lower than the fair value of the common stock as of the end of the reporting period. There were no stock options granted during the three months ended September 30, 2023. The weighted-average grant date fair value of the Company’s stock options granted during the three months ended September 30, 2022 was $1.78. The total fair value of options vested during the three months ended September 30, 2023 and 2022 was $2.0 million and $1.8 million, respectively. Stock-based compensation expense Stock-based compensation expense included in the Company’s condensed consolidated statements of operations is as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Research and development |
$ |
183 |
|
|
$ |
505 |
|
|
$ |
820 |
|
|
$ |
1,393 |
|
General and administrative |
|
416 |
|
|
|
688 |
|
|
|
1,597 |
|
|
|
2,420 |
|
Total stock-based compensation expense |
$ |
599 |
|
|
$ |
1,193 |
|
|
$ |
2,417 |
|
|
$ |
3,813 |
|
|
X |
- DefinitionThe entire disclosure for share-based payment arrangement.
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v3.23.3
Net Loss per Share
|
9 Months Ended |
Sep. 30, 2023 |
Earnings Per Share [Abstract] |
|
Net Loss Per Share |
9. Net loss per share The Company’s potentially dilutive securities have been excluded from the computation of diluted net loss per share as the effect would be to reduce the net loss per share. Therefore, the weighted-average number of common shares outstanding used to calculate both basic and diluted net loss per share attributable to common stockholders is the same. The Company excluded the following shares from the computation of diluted net loss per share attributable to common stockholders as of September 30, 2023 and 2022 because including them would have had an anti-dilutive effect:
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
Options to purchase common stock |
|
|
2,672,831 |
|
|
|
3,659,788 |
|
Unvested shares from early exercises |
|
|
7,333 |
|
|
|
84,771 |
|
|
X |
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v3.23.3
Commitments and Contingencies
|
9 Months Ended |
Sep. 30, 2023 |
Commitments and Contingencies Disclosure [Abstract] |
|
Commitments and Contingencies |
10. Commitments and Contingencies Legal proceedings From time to time, in the ordinary course of business, the Company is subject to litigation and regulatory examinations as well as information gathering requests, inquiries and investigations. As of September 30, 2023, there were no matters which would have a material impact on the Company’s financial results.
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v3.23.3
Leases
|
9 Months Ended |
Sep. 30, 2023 |
Leases [Abstract] |
|
Leases |
11. Leases Operating Lease In August 2018, the Company entered into an operating lease agreement (the "Lease") for office and laboratory space within the building complex located at 128 Spring Street in Lexington, Massachusetts. The Lease commenced in November 2018, and as subsequently amended, is approximately 14,636 rentable square feet (“Original Premises”) and had a maturity date of October 31, 2023. In July 2021, the Company entered into the second amendment of the Lease and expanded the office space by approximately 5,531 square feet (the “Expansion Premises”), and extended the maturity date to December 31, 2025 for both the Original Premises and Expansion Premises. Lease payments are made monthly, subject to a 3% annual rent increase, and the Company pays for its proportionate share of building operating costs such as maintenance, utilities, and insurance that are treated as variable costs and excluded from the measurement of the Lease. On March 29, 2023, the Company entered into a Lease Amendment and Termination Agreement (the “Amendment”) with respect to the operating lease with 99 Hayden LLC, which covers certain laboratory and office space at Ledgemont Technology Center at 99 Hayden Avenue, Lexington, Massachusetts (the “Premises”). The Amendment amends the terms of the Lease to terminate the Lease as of March 31, 2023, subject to completion of the requisite surrender requirements, with respect to approximately 14,636 rentable square feet consisting of office and lab space located on two floors of the Premises, and 140 rentable square feet of storage space located on the Premises. Under the terms of the Amendment, the Company retained and consolidated into the remaining 5,531 rentable square feet of office space under the Lease at the Premises, which were to serve as the Company's principal executive office, until October 31, 2023, at which time the Lease would have terminated in its entirety. The Company recognized a gain on lease terminations and modification of $0.3 million for the nine months ended September 30, 2023 on the condensed consolidated statement of operations and derecognized $2.2 million in lease liabilities and $1.9 million in right of use assets on the condensed consolidated balance sheets. The following table summarizes the presentation of the Company's operating leases on its consolidated balance sheet:
|
|
|
|
|
|
|
|
|
Leases |
Balance sheet classification |
|
September 30, 2023 |
|
December 31, 2022 |
|
Assets |
|
|
|
|
|
|
Operating lease assets |
Other assets |
|
$ |
— |
|
$ |
2,066 |
|
Liabilities |
|
|
|
|
|
|
Current |
|
|
|
|
|
|
Operating lease liabilities |
Accrued expenses and other current liabilities |
|
$ |
16 |
|
$ |
889 |
|
Noncurrent |
|
|
|
|
|
|
Operating lease liabilities |
Other long term liabilities |
|
|
— |
|
|
1,560 |
|
Total lease liabilities |
|
|
$ |
16 |
|
$ |
2,449 |
|
The components of lease cost under ASC 842 included in the Company’s condensed consolidated statement of operations for the nine months ended September 30, 2023 and 2022 were as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
Lease Cost |
Statement of operations classification |
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Operating lease cost |
Research and development |
|
$ |
11 |
|
|
$ |
143 |
|
|
$ |
141 |
|
|
$ |
447 |
|
Operating lease cost |
General and administrative |
|
|
7 |
|
|
|
44 |
|
|
|
88 |
|
|
|
124 |
|
Variable lease cost |
Research and development |
|
|
— |
|
|
|
100 |
|
|
|
101 |
|
|
|
344 |
|
Variable lease cost |
General and administrative |
|
|
— |
|
|
|
31 |
|
|
|
63 |
|
|
|
96 |
|
Total lease cost |
|
|
$ |
18 |
|
|
$ |
318 |
|
|
$ |
393 |
|
|
$ |
1,011 |
|
The weighted average remaining lease term and weighted average discount rate of the operating leases was 0.1 years and 5.0%, respectively, at September 30, 2023. The Company made cash payments for amounts included in the measurement of operating liabilities of $0.3 million for the nine months ended September 30, 2023. Future minimum lease payments under non-cancellable operating leases as of September 30, 2023 were as follows (in thousands):
|
|
|
|
|
Maturity of lease liabilities |
|
Amount |
|
2023 (excluding the nine months ended September 30, 2023) |
|
$ |
16 |
|
Less: interest |
|
|
— |
|
Present value of operating lease liabilities |
|
$ |
16 |
|
|
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v3.23.3
Employee benefit plans
|
9 Months Ended |
Sep. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Employee benefit plans |
12. Employee benefit plans The Company has a 401(k) retirement plan for its employees, which is designed to be qualified under Section 401(k) of the Internal Revenue Code. Eligible employees are permitted to contribute to the 401(k) plan within statutory and 401(k) plan limits. The Company implemented a matching contribution in 2022 and has made $0.1 million matching contributions for the nine months ended September 30, 2023.
|
X |
- DefinitionThe entire disclosure for retirement benefits.
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v3.23.3
Restructuring
|
9 Months Ended |
Sep. 30, 2023 |
Restructuring and Related Activities [Abstract] |
|
Restructuring |
13. Restructuring On January 19, 2023, the Company announced a strategic prioritization of clinical development of CYT-0851, which included the discontinuation of preclinical efforts and a workforce reduction by approximately 70% of the Company's workforce. For the nine months ended September 30, 2023, the Company incurred $4.4 million of restructuring charges related to termination benefits and other related charges of which $2.5 million and $1.8 million, respectively, were recorded in research and development expenses and general and administrative expenses in the Company's condensed consolidated statements of operations. Non-cash expenses related to the strategic prioritization, consisting of an estimated $0.9 million loss on disposal of property and equipment and a gain of $0.3 million on lease terminations and modification and were recorded in other income (expense) in the Company's condensed consolidated statements of operations. On June 30, 2023, the Company's Board of Directors announced its discontinuation of all development of CYT-0851 and intention to dissolve the Company. On September 7, 2023, our Board of Directors unanimously approved, subject to stockholder approval, the liquidation and dissolution of the Company pursuant to a plan of liquidation and dissolution. For the three months ended September 30, 2023, the Company reduced restructuring charges by $0.3 million related to termination benefits which was recorded in research and development expenses in the Company's condensed consolidated statements of operations. For the nine months ended September 30, 2023, the Company made $2.3 million of cash payments related to the restructuring. As of September 30, 2023, the restructuring accrual was approximately $2.1 million and was recorded in accrued expenses and other current liabilities in the Company's condensed consolidated balance sheet. The following table outlines the Company's restructuring activities for the nine months ended September 30, 2023 (in thousands):
|
|
|
|
|
Opening Balance - December 31, 2022 |
|
$ |
- |
|
Employee termination-related charges |
|
|
4,370 |
|
Payments |
|
|
(2,318 |
) |
Balance - September 30, 2023 |
|
$ |
2,052 |
|
|
X |
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v3.23.3
Subsequent Events
|
9 Months Ended |
Sep. 30, 2023 |
Subsequent Events [Abstract] |
|
Subsequent Events |
14. Subsequent events On October 3, 2023, the Company entered into the fourth amendment of the Lease and extended the term of the Lease for an additional one-month term, commencing on November 1, 2023 and expiring on November 30, 2023. Under the terms of the fourth amendment, the Company will continue to lease 5,531 square feet of office space pursuant to the Lease, which will continue to serve as the Company's principal executive office during the extended term.
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v3.23.3
Summary of Significant Accounting Policies (Policies)
|
9 Months Ended |
Sep. 30, 2023 |
Accounting Policies [Abstract] |
|
Interim Financial Information |
Interim Financial Information The accompanying condensed consolidated balance sheet at September 30, 2023, and the condensed consolidated statements of operations, statements of changes in stockholders’ equity for the three and nine months ended September 30, 2023 and 2022 and condensed consolidated statements of cash flows for the nine months ended September 30, 2023 and 2022 are unaudited. The condensed consolidated interim financial statements have been prepared on the same basis as the audited annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments necessary for the fair presentation of the Company’s financial position at September 30, 2023 and the results of its operations for the three and nine months ended September 30, 2023 and 2022 and its cash flows for the nine months ended September 30, 2023 and 2022. The financial data and other information disclosed in these notes related to the three and nine months ended September 30, 2023 and 2022 are also unaudited. The results for the three and nine months ended September 30, 2023 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.
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v3.23.3
Fair Value Measurement (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Fair Value Disclosures [Abstract] |
|
Schedule of Financial Assets and Liabilities Measured at Fair Value On Recurring Basis |
The following tables present information about the Company’s financial assets and liabilities measured at fair value on a recurring basis (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
Assets: |
|
Total |
|
|
Quoted prices in active markets for identical assets (level 1) |
|
|
Significant other observable inputs (level 2) |
|
|
Significant other observable inputs (level 3) |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
128,954 |
|
|
$ |
128,954 |
|
|
$ |
— |
|
|
$ |
— |
|
Total assets |
|
$ |
128,954 |
|
|
$ |
128,954 |
|
|
$ |
|
|
|
$ |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2022 |
|
Assets |
|
Total |
|
|
Quoted prices in active markets for identical assets (level 1) |
|
|
Significant other observable inputs (level 2) |
|
|
Significant other observable inputs (level 3) |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
146,870 |
|
|
$ |
146,870 |
|
|
$ |
— |
|
|
$ |
— |
|
Total assets |
|
$ |
146,870 |
|
|
$ |
146,870 |
|
|
$ |
— |
|
|
$ |
— |
|
|
X |
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- DefinitionTabular disclosure of assets and liabilities, including [financial] instruments measured at fair value that are classified in stockholders' equity, if any, that are measured at fair value on a recurring basis. The disclosures contemplated herein include the fair value measurements at the reporting date by the level within the fair value hierarchy in which the fair value measurements in their entirety fall, segregating fair value measurements using quoted prices in active markets for identical assets (Level 1), significant other observable inputs (Level 2), and significant unobservable inputs (Level 3).
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X |
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v3.23.3
Property and Equipment, Net (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Property, Plant and Equipment [Abstract] |
|
Schedule of Property and Equipment, Net |
Property and equipment, net consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
Acquisition cost |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
1,846 |
|
|
$ |
1,675 |
|
|
$ |
3,521 |
|
Disposals |
|
|
(1,752 |
) |
|
|
(1,266 |
) |
|
|
(3,018 |
) |
As of September 30, 2023 |
|
$ |
94 |
|
|
$ |
409 |
|
|
$ |
503 |
|
|
|
|
|
|
|
|
|
|
|
Accumulated depreciation and amortization |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
(827 |
) |
|
$ |
(995 |
) |
|
$ |
(1,822 |
) |
Depreciation expense |
|
|
(63 |
) |
|
|
(305 |
) |
|
|
(368 |
) |
Disposals |
|
|
866 |
|
|
|
926 |
|
|
|
1,792 |
|
As of September 30, 2023 |
|
$ |
(24 |
) |
|
$ |
(374 |
) |
|
$ |
(398 |
) |
|
|
|
|
|
|
|
|
|
|
Carrying amount |
|
Laboratory and computer equipment |
|
|
Leasehold improvements |
|
|
Total |
|
As of December 31, 2022 |
|
$ |
1,019 |
|
|
$ |
680 |
|
|
$ |
1,699 |
|
As of September 30, 2023 |
|
$ |
70 |
|
|
$ |
35 |
|
|
$ |
105 |
|
|
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v3.23.3
Accrued Expenses and Other Current Liabilities (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Payables and Accruals [Abstract] |
|
Summary of Accrued Expenses and Other Current Liabilities |
Accrued expenses and other current liabilities consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Accrued research and development expenses |
|
$ |
1,646 |
|
|
$ |
1,356 |
|
Accrued compensation |
|
|
3,449 |
|
|
|
1,510 |
|
Accrued other |
|
|
350 |
|
|
|
432 |
|
Operating lease liabilities |
|
|
16 |
|
|
|
889 |
|
Total accrued expenses and other current liabilities |
|
$ |
5,461 |
|
|
$ |
4,187 |
|
|
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v3.23.3
Common Stock (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Equity [Abstract] |
|
Schedule of Common Stock for Potential Exercise of Stock Options |
As of September 30, 2023 and December 31, 2022, the Company has reserved the following shares of common stock for the potential exercise of stock options:
|
|
|
|
|
|
|
|
|
|
|
September 30, |
|
|
December 31, |
|
|
|
2023 |
|
|
2022 |
|
Options to purchase common stock |
|
|
2,672,831 |
|
|
|
3,460,897 |
|
Remaining shares reserved for future issuance |
|
|
7,820,567 |
|
|
|
5,706,345 |
|
Total |
|
|
10,493,398 |
|
|
|
9,167,242 |
|
|
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- DefinitionTabular disclosure of information related to converting stock into another financial instrument(s) in a noncash (or part noncash) transaction.
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v3.23.3
Stock-based Compensation (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Assumptions Used in Black Scholes Option-Pricing Model to Determine Grant Fair Value of Stock Option |
The assumptions that the Company used in the Black Scholes option-pricing model to determine the grant date fair value of stock options granted were as follows:
|
|
|
|
|
|
September 30, 2023 |
December 31, 2022 |
Risk-free interest rate range |
|
3.64-3.65% |
1.89%-4.23% |
Dividend yield |
|
0.0% |
0.0% |
Expected life of options (years) |
|
6.0 |
6.0 |
Volatility rate range |
|
93.0-93.3% |
92.4%-93.3% |
|
Schedule of Stock Option Activity |
The following table summarizes the Company’s stock option activity during the nine months ended September 30, 2023:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number of shares |
|
|
Weighted average exercise price |
|
|
Weighted average remaining contractual term (in years) |
|
|
Aggregate intrinsic value (in thousands) |
|
Outstanding as of December 31, 2022 |
|
|
3,460,897 |
|
|
$ |
5.60 |
|
|
|
8.23 |
|
|
$ |
375 |
|
Granted |
|
|
1,054,357 |
|
|
$ |
1.69 |
|
|
|
— |
|
|
|
— |
|
Exercised |
|
|
(457,579 |
) |
|
$ |
1.32 |
|
|
|
— |
|
|
|
— |
|
Forfeited or cancelled |
|
|
(1,384,844 |
) |
|
$ |
5.55 |
|
|
|
— |
|
|
|
— |
|
Outstanding as of September 30, 2023 |
|
|
2,672,831 |
|
|
$ |
4.82 |
|
|
|
8.02 |
|
|
$ |
1,530 |
|
Options vested and exercisable as of September 30, 2023 |
|
|
1,439,617 |
|
|
$ |
6.04 |
|
|
|
7.37 |
|
|
$ |
575 |
|
|
Schedule of Stock Based Compensation Expense |
Stock-based compensation expense included in the Company’s condensed consolidated statements of operations is as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Research and development |
$ |
183 |
|
|
$ |
505 |
|
|
$ |
820 |
|
|
$ |
1,393 |
|
General and administrative |
|
416 |
|
|
|
688 |
|
|
|
1,597 |
|
|
|
2,420 |
|
Total stock-based compensation expense |
$ |
599 |
|
|
$ |
1,193 |
|
|
$ |
2,417 |
|
|
$ |
3,813 |
|
|
X |
- DefinitionTabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.
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v3.23.3
Net Loss per Share (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Earnings Per Share [Abstract] |
|
Computation of Diluted Net Loss per Share Attributable to Common Stockholders |
The Company excluded the following shares from the computation of diluted net loss per share attributable to common stockholders as of September 30, 2023 and 2022 because including them would have had an anti-dilutive effect:
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
Options to purchase common stock |
|
|
2,672,831 |
|
|
|
3,659,788 |
|
Unvested shares from early exercises |
|
|
7,333 |
|
|
|
84,771 |
|
|
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v3.23.3
Leases (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Leases [Abstract] |
|
Summary of Operating Leases on Consolidated Balance Sheet |
The following table summarizes the presentation of the Company's operating leases on its consolidated balance sheet:
|
|
|
|
|
|
|
|
|
Leases |
Balance sheet classification |
|
September 30, 2023 |
|
December 31, 2022 |
|
Assets |
|
|
|
|
|
|
Operating lease assets |
Other assets |
|
$ |
— |
|
$ |
2,066 |
|
Liabilities |
|
|
|
|
|
|
Current |
|
|
|
|
|
|
Operating lease liabilities |
Accrued expenses and other current liabilities |
|
$ |
16 |
|
$ |
889 |
|
Noncurrent |
|
|
|
|
|
|
Operating lease liabilities |
Other long term liabilities |
|
|
— |
|
|
1,560 |
|
Total lease liabilities |
|
|
$ |
16 |
|
$ |
2,449 |
|
|
Components of Lease Cost |
The components of lease cost under ASC 842 included in the Company’s condensed consolidated statement of operations for the nine months ended September 30, 2023 and 2022 were as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
Lease Cost |
Statement of operations classification |
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Operating lease cost |
Research and development |
|
$ |
11 |
|
|
$ |
143 |
|
|
$ |
141 |
|
|
$ |
447 |
|
Operating lease cost |
General and administrative |
|
|
7 |
|
|
|
44 |
|
|
|
88 |
|
|
|
124 |
|
Variable lease cost |
Research and development |
|
|
— |
|
|
|
100 |
|
|
|
101 |
|
|
|
344 |
|
Variable lease cost |
General and administrative |
|
|
— |
|
|
|
31 |
|
|
|
63 |
|
|
|
96 |
|
Total lease cost |
|
|
$ |
18 |
|
|
$ |
318 |
|
|
$ |
393 |
|
|
$ |
1,011 |
|
|
Schedule of Future Minimum Payments Required Under Non-cancellable Operating Leases |
Future minimum lease payments under non-cancellable operating leases as of September 30, 2023 were as follows (in thousands):
|
|
|
|
|
Maturity of lease liabilities |
|
Amount |
|
2023 (excluding the nine months ended September 30, 2023) |
|
$ |
16 |
|
Less: interest |
|
|
— |
|
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v3.23.3
Fair Value Measurement - Schedule of Financial Assets and Liabilities Measured at Fair Value On Recurring Basis (Details) - Recurring - USD ($) $ in Thousands |
Sep. 30, 2023 |
Dec. 31, 2022 |
Assets: |
|
|
Total assets |
$ 128,954
|
$ 146,870
|
Money Market Funds |
|
|
Assets: |
|
|
Cash equivalents |
128,954
|
146,870
|
Quoted Prices in Active Markets for Identical Assets (Level 1) |
|
|
Assets: |
|
|
Total assets |
128,954
|
146,870
|
Quoted Prices in Active Markets for Identical Assets (Level 1) | Money Market Funds |
|
|
Assets: |
|
|
Cash equivalents |
$ 128,954
|
$ 146,870
|
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v3.23.3
Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) - USD ($) $ in Thousands |
9 Months Ended |
|
Sep. 30, 2023 |
Dec. 31, 2022 |
Property Plant And Equipment [Line Items] |
|
|
Acquisition cost, Beginning Balance |
$ 3,521
|
|
Acquisition cost, Disposals |
(3,018)
|
|
Acquisition cost, Ending Balance |
503
|
|
Accumulated depreciation and amortization, beginning balance |
(1,822)
|
|
Accumulated depreciation and amortization, Depreciation expense |
(368)
|
|
Accumulated depreciation and amortization, Disposals |
1,792
|
|
Accumulated depreciation and amortization, Ending balance |
(398)
|
|
Property and equipment, net |
105
|
$ 1,699
|
Laboratory and Computer Equipment |
|
|
Property Plant And Equipment [Line Items] |
|
|
Acquisition cost, Beginning Balance |
1,846
|
|
Acquisition cost, Disposals |
(1,752)
|
|
Acquisition cost, Ending Balance |
94
|
|
Accumulated depreciation and amortization, beginning balance |
(827)
|
|
Accumulated depreciation and amortization, Depreciation expense |
(63)
|
|
Accumulated depreciation and amortization, Disposals |
866
|
|
Accumulated depreciation and amortization, Ending balance |
(24)
|
|
Property and equipment, net |
70
|
1,019
|
Leasehold Improvements |
|
|
Property Plant And Equipment [Line Items] |
|
|
Acquisition cost, Beginning Balance |
1,675
|
|
Acquisition cost, Disposals |
(1,266)
|
|
Acquisition cost, Ending Balance |
409
|
|
Accumulated depreciation and amortization, beginning balance |
(995)
|
|
Accumulated depreciation and amortization, Depreciation expense |
(305)
|
|
Accumulated depreciation and amortization, Disposals |
926
|
|
Accumulated depreciation and amortization, Ending balance |
(374)
|
|
Property and equipment, net |
$ 35
|
$ 680
|
X |
- DefinitionAmount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.
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v3.23.3
Common Stock - Additional Information (Details)
|
9 Months Ended |
Sep. 30, 2023 |
Equity [Abstract] |
|
Common stock, voting rights |
The holders of the common stock are entitled to one vote for each share of common stock held submitted to a vote of stockholders, and there are not any cumulative voting rights.
|
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v3.23.3
Common Stock - Schedule of Common Stock for Potential Exercise of Stock Options (Details) - shares
|
Sep. 30, 2023 |
Dec. 31, 2022 |
Class Of Stock [Line Items] |
|
|
Common stock issuable upon conversion |
10,493,398
|
9,167,242
|
Options to Purchase Common Stock |
|
|
Class Of Stock [Line Items] |
|
|
Common stock issuable upon conversion |
2,672,831
|
3,460,897
|
Remaining Shares Reserved for Future Issuance |
|
|
Class Of Stock [Line Items] |
|
|
Common stock issuable upon conversion |
7,820,567
|
5,706,345
|
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v3.23.3
Stock-based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions |
|
|
3 Months Ended |
9 Months Ended |
|
Jan. 01, 2023 |
Jun. 21, 2021 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Dec. 31, 2022 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Issuance of shares of common stock |
|
|
10,493,398
|
|
10,493,398
|
9,167,242
|
Weighted average exercise price |
|
|
$ 4.82
|
|
$ 4.82
|
$ 5.60
|
Weighted-average grant date fair value of stock options granted |
|
|
|
$ 1.78
|
|
|
Stock options granted |
|
|
0
|
|
1,054,357
|
|
Weighted-average period |
|
|
|
|
2 years 3 months 18 days
|
|
Total fair value of options vested |
|
|
$ 2.0
|
$ 1.8
|
|
|
Unvested Stock Options |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Unvested shares related to early exercises of stock options |
|
|
7,333
|
|
7,333
|
59,445
|
2012 Stock Incentive Plan |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Maximum term of options granted |
|
|
|
|
10 years
|
|
Vesting period |
|
|
|
|
4 years
|
|
Common stock available for future grant |
|
|
2,732,632
|
|
2,732,632
|
|
Unrecognized stock based compensation expense |
|
|
$ 2.9
|
|
$ 2.9
|
|
2012 Stock Incentive Plan | Maximum |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Issuance of shares of common stock |
|
|
6,941,421
|
|
6,941,421
|
|
2021 Equity Incentive Plan |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Issuance of shares of common stock |
|
|
5,932,632
|
|
5,932,632
|
|
Common stock available for future grant |
|
|
7,820,567
|
|
7,820,567
|
|
Percentage of number of shares of stock outstanding |
|
5.00%
|
|
|
|
|
Increase in common stock reserved and available for issuance |
1,778,784
|
|
|
|
|
|
2021 Employee Stock Purchase Plan |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Percentage of number of shares of stock outstanding |
|
1.00%
|
|
|
|
|
Proceeds from ESPP |
|
|
|
|
$ 0.1
|
|
Increase in common stock reserved and available for issuance |
355,756
|
|
|
|
|
|
Number of share increase |
|
|
|
|
600,000
|
|
2021 Employee Stock Purchase Plan | Common Stock |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Number of shares issued |
|
|
|
|
62,754
|
|
Weighted average exercise price |
|
|
$ 1.45
|
|
$ 1.45
|
|
2021 Employee Stock Purchase Plan | Maximum |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Issuance of shares of common stock |
|
300,000
|
|
|
|
|
Number of shares of stock authorized |
|
|
6,300,000
|
|
6,300,000
|
|
Current Equity Incentive Plan |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Issuance of shares of common stock |
|
|
3,200,000
|
|
3,200,000
|
|
2012 Shares Made Available 2021 Equity Incentive Plan |
|
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
|
Issuance of shares of common stock |
|
|
2,732,632
|
|
2,732,632
|
|
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v3.23.3
Stock-based Compensation - Schedule of Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands |
3 Months Ended |
9 Months Ended |
12 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2023 |
Dec. 31, 2022 |
Share-Based Payment Arrangement [Abstract] |
|
|
|
Number of shares, beginning balance |
|
3,460,897
|
|
Number of shares, Granted |
0
|
1,054,357
|
|
Number of shares, Exercised |
|
(457,579)
|
|
Number of shares, Forfeited or cancelled |
|
(1,384,844)
|
|
Number of shares, ending balance |
2,672,831
|
2,672,831
|
3,460,897
|
Number of shares, Options vested and exercisable |
1,439,617
|
1,439,617
|
|
Weighted average exercise price, beginning balance |
|
$ 5.60
|
|
Weighted average exercise price, Granted |
|
1.69
|
|
Weighted average exercise price, Exercised |
|
1.32
|
|
Weighted average exercise price, Forfeited or cancelled |
|
5.55
|
|
Weighted average exercise price, ending balance |
$ 4.82
|
4.82
|
$ 5.60
|
Weighted average exercise price, Options vested and exercisable |
$ 6.04
|
$ 6.04
|
|
Weighted average remaining contractual term (in years), balance |
|
8 years 7 days
|
8 years 2 months 23 days
|
Weighted average remaining contractual term (in years), Options vested and exercisable |
|
7 years 4 months 13 days
|
|
Aggregate intrinsic value, beginning balance |
|
$ 375
|
|
Aggregate intrinsic value, ending balance |
$ 1,530
|
1,530
|
$ 375
|
Aggregate intrinsic value, Options vested and exercisable |
$ 575
|
$ 575
|
|
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v3.23.3
Stock-based Compensation - Schedule of Stock Based Compensation Expense (Details) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Total stock-based compensation expense |
$ 599
|
$ 1,193
|
$ 2,417
|
$ 3,813
|
Research and Development |
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Total stock-based compensation expense |
183
|
505
|
820
|
1,393
|
General and Administrative |
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Total stock-based compensation expense |
$ 416
|
$ 688
|
$ 1,597
|
$ 2,420
|
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v3.23.3
Leases - Additional Information (Details) $ in Thousands |
1 Months Ended |
9 Months Ended |
|
Jul. 31, 2021
ft²
|
Aug. 31, 2018
ft²
|
Sep. 30, 2023
USD ($)
|
Mar. 29, 2023
ft²
Floor
|
Lessee, Lease, Description [Line Items] |
|
|
|
|
Operating lease, weighted average remaining lease term |
|
|
1 month 6 days
|
|
Operating lease, weighted average discount rate |
|
|
5.00%
|
|
Operating lease, payments | $ |
|
|
$ 300
|
|
Operating Lease Liability Derecognized | $ |
|
|
2,200
|
|
Right of Use Assets Derecognized | $ |
|
|
1,900
|
|
Gain on lease terminations and modification | $ |
|
|
$ 318
|
|
Massachusetts |
|
|
|
|
Lessee, Lease, Description [Line Items] |
|
|
|
|
Total rentable area |
|
|
|
5,531
|
Premises | Massachusetts |
|
|
|
|
Lessee, Lease, Description [Line Items] |
|
|
|
|
Total rentable area |
|
14,636
|
|
|
Lease expiration date |
|
Oct. 31, 2023
|
|
|
Number of square feet expanding |
5,531
|
|
|
|
Operating lease extended maturity date |
Dec. 31, 2025
|
|
|
|
Description of option to extend operating lease |
|
|
In July 2021, the Company entered into the second amendment of the Lease and expanded the office space by approximately 5,531 square feet (the “Expansion Premises”), and extended the maturity date to December 31, 2025 for both the Original Premises and Expansion Premises.
|
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Existence option to extend operating lease |
true
|
|
|
|
Increase in annual rent percentage |
3.00%
|
|
|
|
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|
|
|
|
Lessee, Lease, Description [Line Items] |
|
|
|
|
Total rentable area |
|
|
|
14,636
|
Number of floors | Floor |
|
|
|
2
|
Storage Space [Member] | Massachusetts |
|
|
|
|
Lessee, Lease, Description [Line Items] |
|
|
|
|
Total rentable area |
|
|
|
140
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v3.23.3
Leases - Summary of Operating Leases on Consolidated Balance Sheet (Details) - USD ($) $ in Thousands |
Sep. 30, 2023 |
Dec. 31, 2022 |
Assets |
|
|
Operating lease assets |
|
$ 2,066
|
Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] |
Other Assets, Noncurrent
|
Other Assets, Noncurrent
|
Liabilities |
|
|
Operating lease liabilities, Current |
$ 16
|
$ 889
|
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] |
Accounts Payable and Other Accrued Liabilities, Current
|
Accounts Payable and Other Accrued Liabilities, Current
|
Operating lease liabilities, Noncurrent |
|
$ 1,560
|
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration] |
Other Liabilities, Noncurrent
|
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|
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$ 16
|
$ 2,449
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v3.23.3
Leases - Components of Lease Cost (Details) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Lessee, Lease, Description [Line Items] |
|
|
|
|
Total lease cost |
$ 18
|
$ 318
|
$ 393
|
$ 1,011
|
Research and Development |
|
|
|
|
Lessee, Lease, Description [Line Items] |
|
|
|
|
Operating lease cost |
11
|
143
|
141
|
447
|
Variable lease cost |
|
100
|
101
|
344
|
General and Administrative |
|
|
|
|
Lessee, Lease, Description [Line Items] |
|
|
|
|
Operating lease cost |
$ 7
|
44
|
88
|
124
|
Variable lease cost |
|
$ 31
|
$ 63
|
$ 96
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