FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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OMB Number: 3235-0287
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Silva Francisco		 2. Issuer Name and Ticker or Trading Symbol

BioRestorative Therapies, Inc. [ BRTX ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
VP of Research and Development
(Last)          (First)          (Middle)

40 MARCUS DRIVE		 3. Date of Earliest Transaction (MM/DD/YYYY)

11/3/2022
(Street)

MELVILLE, NY 11747
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock         165103 (1)D  
Common Stock         12136 I IRA 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option $3000.            (2)12/7/2022 Common Stock 1  1 D  
Stock Option $3000.            (2)10/4/2023 Common Stock 1  1 D  
Stock Option $3000.            (2)2/18/2024 Common Stock 3  3 D  
Stock Option $3000           3/12/2014 3/11/2024 Common Stock 1  1 D  
Stock Option $3000            (2)10/23/2024 Common Stock 9  9 D  
Stock Option $3000            (2)9/4/2025 Common Stock 6  6 D  
Stock Option $3000            (2)6/10/2026 Common Stock 15  15 D  
Stock Option $3000            (2)7/12/2027 Common Stock 20  20 D  
Stock Option $3000            (2)10/29/2028 Common Stock 25  25 D  
Stock Option $13.5 11/3/2022  D     293479   (3)3/18/2031 Common Stock 293479 $0 (5)0 D  
Stock Option $5.08 11/3/2022  A   293479     (3)3/18/2031 Common Stock 293479 $0 (5)293479 D  
Stock Option $13.5 11/3/2022  D     42059   (4)11/4/2031 Common Stock 42059 $0 (5)0 D  
Stock Option $5.08 11/3/2022  A   42059     (4)11/4/2031 Common Stock 42059 $0 (5)42059 D  
Explanation of Responses:
(1) Includes 103,008 shares received pursuant to an unvested restricted stock unit grant. Such shares vest to the extent of 1,036 shares on November 18, 2022 and January 18, 2023, 1,037 shares on December 18, 2022 and February 18, 2023, 49,949 shares on March 18, 2023 and 48,913 shares on March 18, 2024.
(2) The option is currently exercisable.
(3) The option vests and becomes exercisable to the extent of 146,740 shares on March 18, 2021, 36,684 shares on November 4, 2021 and the remaining 110,055 shares in six nearly equal quarterly installments beginning December 18, 2021 and continuing every three months thereafter until fully vested.
(4) The option vests and becomes exercisable to the extent of 21,030 shares on November 4, 2021 with the remaining 21,029 shares vesting quarterly in eight nearly equal installments beginning on November 4, 2022.
(5) The reported transactions involved an amendment of an outstanding stock option, resulting in the deemed cancellation of the "old" stock option and the grant of a "replacement" stock option with a reduced exercise price.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Silva Francisco
40 MARCUS DRIVE
MELVILLE, NY 11747		X
VP of Research and Development
Signatures
/s/ Francisco Silva11/3/2022
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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